Digital Commons Network^™

Influence Of Polypyrrole On Phosphorus- And Tio2-Based Anode Nanomaterials For Li-Ion Batteries, Chiwon Kang, Kibum Song, Seungho Ha, Yujin Sung, Yejin Kim, Keun-Young Shin, Byung Hyo Kim

Faculty, Staff and Student Publications

Phosphorus (P) and TiO2 have been extensively studied as anode materials for lithium-ion batteries (LIBs) due to their high specific capacities. However, P is limited by low electrical conductivity and significant volume changes during charge and discharge cycles, while TiO2 is hindered by low electrical conductivity and slow Li-ion diffusion. To address these issues, we synthesized organic–inorganic hybrid anode materials of P–polypyrrole (PPy) and TiO2–PPy, through in situ polymerization of pyrrole monomer in the presence of the nanoscale inorganic materials. These hybrid anode materials showed higher cycling stability and capacity compared to pure P and TiO2. The enhancements are attributed …

Disambiguation Of Aerococcus Urinae Species Diversity, Brian Ian Choi

Dissertations

Aerococcus urinae is an uncommon inhabitant of the human urogenital tract. The Gram-positive bacterium has been implicated in a wide range of urinary tract diseases that, if left untreated or undiagnosed, can progress to severe disease such as infective endocarditis. Comparative analysis of 115 A. urinae isolates from infection episodes of urinary tract infection, bacteremia, infective endocarditis, urgency urinary incontinence, stress urinary incontinence, interstitial cystitis / painful bladder syndrome, and asymptomatic individuals reveal substantial diversity with respect to predicted virulence factors, metabolism, and observed biofilm behavior. Through whole genome sequencing analysis, these strains can be reorganized into six new taxonomic …

Targeted Home Systems To Remove Pfas More Cost-Effective Than System-Wide Solutions, Aaron Sanborn

UNH Today Archive

No abstract provided.

Understanding The Retrospective And Current Health Care Needs And Service Experiences Of Adult Survivors Of Minor Sex Trafficking, Amelia Wagner, Sarah Lockwood, Amy Farrell, Carlos Cuevas, Jennifer E. O'Brien, Rebecca Pfeffer, Jaclyn Kolnik, Alisa Lincoln

Faculty Publications

Minor sex trafficking is an urgent public health problem, but we lack data about how such experiences impact health and health care access. Utilizing data collected from in-depth interviews with 35 adult survivors of minor sex trafficking across the U.S. we explored the physical and psychological healthcare access and healthcare experiences of adult survivors of minor sex trafficking. Negative healthcare experiences before, during, and following sex trafficking foster a lack of trust and confidence in healthcare systems as adults. Recommendations are provided to help overcome barriers to meeting healthcare needs and improving health care experiences for survivors of minor sex …

Understanding The Retrospective And Current Health Care Needs And Service Experiences Of Adult Survivors Of Minor Sex Trafficking, Amelia Wagner, Sarah Lockwood, Amy Farrell, Carlos Cuevas, Jennifer E. O'Brien, Rebecca Pfeffer, Jaclyn Kolnik, Alisa Lincoln

Faculty Publications

Minor sex trafficking is an urgent public health problem, but we lack data about how such experiences impact health and health care access. Utilizing data collected from in-depth interviews with 35 adult survivors of minor sex trafficking across the U.S. we explored the physical and psychological healthcare access and healthcare experiences of adult survivors of minor sex trafficking. Negative healthcare experiences before, during, and following sex trafficking foster a lack of trust and confidence in healthcare systems as adults. Recommendations are provided to help overcome barriers to meeting healthcare needs and improving health care experiences for survivors of minor sex …

A Novel Use Of Social Network Analysis And Routinely Collected Data To Uncover Care Coordination Processes For Patients With Heart Failure, Sijia Wei

Dissertations

Effective patient care transitions require consideration of the patient's social and clinical contexts, yet how these factors relate to the processes in care coordination remains poorly described. This dissertation aimed to describe provider networks and clinical care and social contexts involved during longitudinal care transitions across settings. The overall purpose of this dissertation is to uncover the longitudinal patterns of utilization and relational processes needed for effective care coordination in transitional care, so we can redesign interventions that focus on informational and relationship networks to improve interaction patterns and system performance for people living with heart failure (HF) as they …

Unveiling The Path To Lgbtq+ Inclusive And Culturally Competent Healthcare: A Multi-Dimensional Examination Of Trainings, Policies, And Perspectives, Hyunmin Yu

Dissertations

LGBTQ+ individuals encounter enduring discrimination and adverse healthcare encounters within the healthcare system, with profound implications for their health and wellbeing. Policymakers have advocated for the adoption of LGBTQ+ inclusive and culturally competent healthcare, including training for health professionals, to promote health equity among LGBTQ+ populations. However, implementation of these policies within healthcare systems varies, posing structural and individual-level barriers. In this dissertation, I employ an ecological model of LGBTQ+ health disparities and a conceptual model of determinants of health disparities in vulnerable populations within the healthcare system to examine the impact of structural inequities on the implementation of LGBTQ+ …

The Evolving Paradigm Of Antibody-Drug Conjugates Targeting The Erbb/Her Family Of Receptor Tyrosine Kinases, Peyton High, Cara Guernsey, Shraddha Subramanian, Joan Jacob, Kendra S Carmon

The Brown Foundation: Institute of Molecular Medicine

Current therapies targeting the human epidermal growth factor receptor (HER) family, including monoclonal antibodies (mAbs) and tyrosine kinase inhibitors (TKIs), are limited by drug resistance and systemic toxicities. Antibody-drug conjugates (ADCs) are one of the most rapidly expanding classes of anti-cancer therapeutics with 13 presently approved by the FDA. Importantly, ADCs represent a promising therapeutic option with the potential to overcome traditional HER-targeted therapy resistance by delivering highly potent cytotoxins specifically to HER-overexpressing cancer cells and exerting both mAb- and payload-mediated antitumor efficacy. The clinical utility of HER-targeted ADCs is exemplified by the immense success of HER2-targeted ADCs including trastuzumab …

Towards An Interdisciplinary “Science Of The Mind”: A Call For Enhanced Collaboration Between Philosophy And Neuroscience, Alessandra Buccella, Uri Maoz, Liad Mudrik

Psychology Faculty Articles and Research

In recent decades, the neuroscientific community has moved from describing the neural underpinnings of mental phenomena—as characterized by experimental psychology and philosophy of mind—to attempting to redefine those mental phenomena based on neural findings. Nowadays, many are intrigued by the idea that neuroscience might provide the “missing piece” that would allow philosophers (and, to an extent, psychologists, too) to make important advances, generating new means that these disciplines lack to close knowledge gaps and answer questions like “What is Free Will?” and “Do humans have it?.” In this paper, we argue that instead of striving for neuroscience to replace philosophy …

Exploration Of The Implementation Of The Workforce Innovation And Opportunity Act By Vocational Rehabilitation Programs Through Collaboration With Education Officials, Elyse Leinani Luke

Walden Dissertations and Doctoral Studies

Despite public policies intended to achieve employment equity for students with disabilities, compared to students without disabilities, transition-age students with disabilities are less likely to be in the workforce even after receiving public vocational rehabilitation (VR) services. The purpose of this qualitative, multicase study was to explore implementation of the Workforce Innovation and Opportunity Act (WIOA) by VR programs through collaboration with state education officials to deliver pre-employment transition services (pre-ETS) to students with disabilities. The Integration Continuum was used to conceptually frame this study because the model provides a hierarchical scale with definitions about how organizations work together at …

Relationships Between Environmental Pollution And Corporate Environmental Violence Within The Florida Energy Sector, Lynne Hodalski-Champagne

Walden Dissertations and Doctoral Studies

Environmental pollution and corporate environmental violence (CEV) have become a primary motivator for research, activism, and policy initiatives. Prior research has involved environmental crime, environmental injustice and racism, its origins, history and applications, and effects on public perceptions leading to recommendations for policy implementation. The purpose of the study was to address environmental pollution in terms of total toxic emissions and CEV through analyses of harm inflicted on life, health, and physical integrity of humans, wildlife, and ecosystems. A quantitative correlational design was used with a Pearson’s r correlation coefficient to determine significance with a 95% confidence interval. Routine activities, …

A Therapist Perspective: Gender Differences In Treatment Recommendations For Adults With Adhd, Inattentive Presentation, Casey Redus

Walden Dissertations and Doctoral Studies

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with onset during childhood and often persisting into adulthood. Statistics show that more men are diagnosed with ADHD than women, and that women are more often diagnosed with ADHD inattentive type. Treatment for ADHD has not focused on non-psychopharmacology gender-based treatment recommendations, and this has been identified as requiring further research. This qualitative study explored therapists' process in making treatment recommendations for women versus men diagnosed with ADHD inattentive subtype. Social role theory was used to underpin the research. The participants of the study included ten licensed psychologists in the state …

Challenges Black Males Face At Predominantly White Institutions, Jerrell Lamon Starling

Walden Dissertations and Doctoral Studies

The problem is that Black males in higher education have declining retention and graduation rates compared to other ethnic groups. Over the past two decades, Black males have declined in enrollment, retention, and graduation rates. Colleges and universities have struggled to attract, keep, and graduate Black male students, especially during the COVID-19 pandemic. Recent research has shown that Black male students have experienced the most challenges during the COVID-19 pandemic. Today's educators and practitioners have emphasized the need to do more to keep Black male students and help them complete college. Framed by Critical Race Theory, this study investigated first-generation, …

Southeastern South Carolina K-12 Teachers’ Perceptions Of The Difficulties In Implementing An Arts-Based Initiatives, Alexis P. Steedman

Walden Dissertations and Doctoral Studies

A public school district in southeast South Carolina implemented a new arts-based initiative due to the surge in demand for mental health services for students following the pandemic. With more students in the research site requiring intensive mental health support during the 2021-2022 academic year, compared to the 2016-2017 school year, the district is expanding its student mental health efforts to encompass a variety of arts-based initiatives to try to alleviate such concerns. The purpose of this basic qualitative study was to explore K-12 teachers' experiences implementing arts-based initiatives and the resources they need when implementing arts-based initiatives in the …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou), Draft Final Residential Metals Abatement Program Investigation Summary Report (Non-Residential – Interior School Dust) - Gold Hill Lutheran Church (Creativity Factory Preschool) (Dated April 8, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Characterization Of The Glyoxal Response In Pseudomonas Aeruginosa, Christopher James Corcoran

Dissertations

The toxic dialdehyde glyoxal is found in all domains of life and results as a by-product from a variety of metabolic activities such as DNA oxidation, lipid peroxidation, and autoxidation of sugars such as glucose. If allowed to accumulate, the reactive aldehyde groups of glyoxal have the ability to react with a plethora of molecules including, DNA, lipids, and protein side chains. Most notably, glyoxal can react with arginine, lysine, and cysteine residues, forming irreversible covalent modifications known as advanced glycation end products (AGEs). These glyoxal-derived AGEs can impair protein function, leading to cellular toxicity and eventual cell death. Due …

Esta Carta De Amor Es Para Ti: An Autoethnography Of An Undocumented Student’S Survival In Higher Education, Cuauhtemoc Salinas Martell

LMU Theses and Dissertations

This dissertation shed light on the need for higher education institutions to design support systems for undocumented students inside and outside of the classroom, especially when they apply to or attend prestigious universities. In addition, this study highlighted how I survived higher education, my home, and U.S. society through my multiple identities. The goal was to use my life experiences to show how powerful it is to be an undocumented student and how such students continue to influence laws, policies, and institutional change to make higher education more accessible and attainable. This study added to the literature on subaltern undocumented …

A Systematic Approach For Evaluating And Selecting Healthcare Waste Treatment Devices Using Owcm-Codas And Triangular Neutrosophic Sets, Asmaa Elsayed, Bilal Arain

Neutrosophic Systems with Applications

Healthcare is a fundamental aspect of human life, impacting individuals, communities, and societies. Investing in healthcare infrastructure, services, and education is essential for fostering a healthy, thriving population. Healthcare waste management is a critical aspect of public health, and it requires a concerted effort from healthcare facilities, governments, and communities to ensure that waste is managed in a way that minimizes risks to human health and the environment. This paper proposes a hybrid methodology combining the Opinion Weight Criteria Method (OWCM) and the Combinative Distance-Based Assessment (CODAS) within the framework of Triangular Neutrosophic Sets (TNS) to evaluate and select the …

Loss Of The Dna Repair Gene Rnase H2 Identifies A Unique Subset Of Ddr-Deficient Leiomyosarcomas, Michael S Nakazawa, Ian M Silverman, Victoria Rimkunas, Artur Veloso, Dominik Glodzik, Adrienne Johnson, Toshiro K Ohsumi, Shreyaskumar R Patel, Anthony P Conley, Christina L Roland, Pamela T Soliman, Hannah C Beird, Chia-Chin Wu, Davis R Ingram, Rossana Lazcano, Dawon Song, Khalida M Wani, Alexander J Lazar, Timothy A Yap, Wei-Lien Wang, J Andrew Livingston

Faculty, Staff and Student Publications

Targeting the DNA damage response (DDR) pathway is an emerging therapeutic approach for leiomyosarcoma (LMS), and loss of RNase H2, a DDR pathway member, is a potentially actionable alteration for DDR-targeted treatments. Therefore, we designed a protein- and genomic-based RNase H2 screening assay to determine its prevalence and prognostic significance. Using a selective RNase H2 antibody on a pan-tumor microarray (TMA), RNase H2 loss was more common in LMS (11.5%, 9/78) than across all tumors (3.8%, 32/843). In a separate LMS cohort, RNase H2 deficiency was confirmed in uterine LMS (U-LMS, 21%, 23/108) and soft-tissue LMS (ST-LMS; 30%, 39/102). In …

Home Blood Pressure Telemonitoring And Nurse Case Management In Black And Hispanic Patients With Stroke: A Randomized Clinical Trial, Gbenga Ogedegbe, Jeanne A Teresi, Stephen K Williams, Adebayo Ogunlade, Chigozirim Izeogu, Joseph P Eimicke, Jian Kong, Stephanie A Silver, Olajide Williams, Helen Valsamis, Susan Law, Steven R Levine, Salina P Waddy, Tanya M Spruill

Faculty, Staff and Student Publications

Importance: Black and Hispanic patients have high rates of recurrent stroke and uncontrolled hypertension in the US. The effectiveness of home blood pressure telemonitoring (HBPTM) and telephonic nurse case management (NCM) among low-income Black and Hispanic patients with stroke is unknown.

Objective: To determine whether NCM plus HBPTM results in greater systolic blood pressure (SBP) reduction at 12 months and lower rate of stroke recurrence at 24 months than HBPTM alone among Black and Hispanic stroke survivors with uncontrolled hypertension.

Design, setting, and participants: Practice-based, multicenter, randomized clinical trial in 8 stroke centers and ambulatory practices in New York City. …

Management Of Blunt Abdominal Trauma, Janet R Ashley, Keith W Burczak, Bryan A Cotton, Thomas W Clements

Faculty, Staff and Student Publications

No abstract provided.

Inhibition Of Malt1 And Bcl2 Induces Synergistic Antitumor Activity In Models Of B-Cell Lymphoma, Joshua P Plotnik, Adam E Richardson, Haopeng Yang, Estela Rojas, Velitchka Bontcheva, Colleen Dowell, Sydney Parsons, Ashley Wilson, Vida Ravanmehr, Christine Will, Paul Jung, Haizhong Zhu, Sarathy Karunan Partha, Sanjay C Panchal, Raghuveer Singh Mali, Frederick J Kohlhapp, Ryan A Mcclure, Cyril Y Ramathal, Mariam D George, Manisha Jhala, Nathaniel L Elsen, Wei Qiu, Russell A Judge, Chin Pan, Anthony Mastracchio, Jared Henderson, Jonathan A Meulbroek, Michael R Green, William N Pappano

Faculty, Staff and Student Publications

The activated B cell (ABC) subset of diffuse large B-cell lymphoma (DLBCL) is characterized by chronic B-cell receptor signaling and associated with poor outcomes when treated with standard therapy. In ABC-DLBCL, MALT1 is a core enzyme that is constitutively activated by stimulation of the B-cell receptor or gain-of-function mutations in upstream components of the signaling pathway, making it an attractive therapeutic target. We discovered a novel small-molecule inhibitor, ABBV-MALT1, that potently shuts down B-cell signaling selectively in ABC-DLBCL preclinical models leading to potent cell growth and xenograft inhibition. We also identified a rational combination partner for ABBV-MALT1 in the BCL2 …

Influential Individuals Can Promote Prosocial Practices In Heterogeneous Societies: A Mathematical And Agent-Based Model, Stefani A. Crabtree, Colin D. Wren, Avinash Dixit, Simon A. Levin

Environment and Society Faculty Publications

In this paper, we examine how different governance types impact prosocial behaviors in a heterogenous society. We construct a general theoretical framework to examine a game-theoretic model to assess the ease of achieving a cooperative outcome. We then build a dynamic agent-based model to examine three distinct governance types in a heterogenous population: monitoring one's neighbors, despotic leadership, and influencing one's neighbors to adapt strategies that lead to better fitness. In our research, we find that while despotic leadership may lead towards high prosociality and high returns it does not exceed the effects of a local individual who can exert …

Barriers And Facilitators To Healthy Eating In Disadvantaged Adults Living In The Uk:: A Scoping Review, R Briazu, F Masood, Louise Hunt, Clare Pettinger, Carol Wagstaff, R Mccloy

School of Health Professions

In the UK people living in disadvantaged communities are less likely than those with higher socio-economic status to have a healthy diet. To address this inequality, it is crucial scientists, practitioners and policy makers understand the factors that hinder and assist healthy food choice in these individuals. In this scoping review, we aimed to identify barriers and facilitators to healthy eating among disadvantaged individuals living in the UK. Additionally, we used the Theoretical Domains Framework (TDF) to synthesise results and provide a guide for the development of theory-informed behaviour change interventions. Five databases were searched, (CINAHL, Embase, MEDLINE, PsycINFO, and …

Experiences From Patients In Mental Healthcare Accessing Their Electronic Health Records: Results From A Cross-National Survey In Estonia, Finland, Norway, And Sweden, A. J. Fagerlund, Annika Bärkås, A. Kharko, C. R. Blease, J. Hagström, I. Huvila, I. Hörhammer, B. Kane, E. Kristiansen, S. Kujala, J. Moll, H. Rexhepi, I. Scandurra, S. Simola, H. Soone, B. Wang, R. M. Åhlfeldt, M. Hägglund, M. A. Johansen

School of Psychology

Background: Patients’ online record access (ORA) enables patients to read and use their health data through online digital solutions. One such solution, patient-accessible electronic health records (PAEHRs) have been implemented in Estonia, Finland, Norway, and Sweden. While accumulated research has pointed to many potential benefits of ORA, its application in mental healthcare (MHC) continues to be contested. The present study aimed to describe MHC users’ overall experiences with national PAEHR services. Methods: The study analysed the MHC-part of the NORDeHEALTH 2022 Patient Survey, a large-scale multi-country survey. The survey consisted of 45 questions, including demographic variables and questions related to …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou), Draft Residential Metals Abatement Program Construction Completion Report (Non-Residential Parcels – Indoor Dust) – Kennedy Elementary (Dated April 17, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Emerging Treatments And Therapies For Autism Spectrum Disorder: A Narrative Review, Alan D. Kaye, Kaitlyn E. Allen, Van S. Smith Iii, Victoria T. Tong, Vivian E. Mire, Huy Nguyen, Zachary Lee, Maria Kouri, Carlo Jean Baptiste, Chizoba N. Mosieri, Adam M. Kaye, Giustino Varrassi, Sahar Shekoohi

School of Medicine Faculty Publications

The prevalence of autism spectrum disorder (ASD) has increased over the last decade. In this regard, many emerging therapies have been described as ASD therapies. Although ASD does not have a cure, there are several management options available that can help reduce symptom severity. ASD is highly variable and, therefore, standard treatment protocols and studies are challenging to perform. Many of these therapies also address comorbidities for which patients with ASD have an increased risk. These concurrent diagnoses can include psychiatric and neurological disorders, including attention deficit and hyperactivity disorder, anxiety disorders, and epilepsy, as well as gastrointestinal symptoms such …

Ruptured Infectious Pseudoaneurysm Of The Common Carotid Artery In A 14-Year-Old Girl. Management In The Dr Congo, Alphonse Nzomvuama, Jean Jacques Kalongo, Blondel Bayenekene, Stéphane Yanda, M. Jacques Nsuami

School of Medicine Faculty Publications

The infectious pseudoaneurysm of the common carotid artery is a rare observation in children. We present a case of ruptured infectious common carotid aneurysm in a 14-year-old girl managed in the Democratic Republic of Congo. We performed an arterial reconstruction with a saphenous vein patch. Post-operative course was simple. The patient was discharged from the hospital at post-operative day 15. She was doing well and had returned to school. Rupture of an infectious pseudoaneurysm of the common carotid artery constitutes a serious, life-threatening accident. As we have shown in this case report, its management with successful results is indeed possible, …

Multidisciplinary Approach To Diagnostic Radiology Education: A Novel Educational Intervention For Turkish Medical Students, Parth Patel, Emre Altınmakas, Görkem Ayas, Rachel Stanietzky, Madeline L. Stewart, Abdelrahman Elshikh, Disha Ram, Hrishika Bhosale, Mohamed Eltaher, Serageldin Kamel, Munevver N. Duran, Umut Yücel, Mohamed Badawy, Scott Rohren, Khaled M. Elsayes

School of Medicine Faculty Publications

Teleconferencing can facilitate a multidisciplinary approach to teaching radiology to medical students. This study aimed to determine whether an online learning approach enables students to appreciate the interrelated roles of radiology and other specialties during the management of different medical cases. Turkish medical students attended five 60-90-minute online lectures delivered by radiologists and other specialists from the United States and Canada through Zoom meetings between November 2020 and January 2021. Student ambassadors from their respective Turkish medical schools recruited their classmates with guidance from the course director. Students took a pretest and posttest to assess the knowledge imparted from each …

Assessment Of Patient-Derived Xenograft Growth And Antitumor Activity: The Nci Pdxnet Consensus Recommendations, Funda Meric-Bernstam, Michael W Lloyd, Soner Koc, Yvonne A Evrard, Lisa M Mcshane, Michael T Lewis, Kurt W Evans, Dali Li, Lawrence Rubinstein, Alana Welm, Dennis A Dean, Anuj Srivastava, Jeffrey W Grover, Min J Ha, Huiqin Chen, Xuelin Huang, Kaushik Varadarajan, Jing Wang, Jack A Roth, Bryan Welm, Ramaswamy Govinden, Li Ding, Salma Kaochar, Nicholas Mitsiades, Luis Carvajal-Carmona, Meenhard Herylyn, Michael A Davies, Geoffrey I Shapiro, Ryan Fields, Jose G Trevino, Joshua C Harrell, Nci Pdxnet Consortium, James H Doroshow, Jeffrey H Chuang, Jeffrey A Moscow

Faculty, Staff and Student Publications

Although patient-derived xenografts (PDX) are commonly used for preclinical modeling in cancer research, a standard approach to in vivo tumor growth analysis and assessment of antitumor activity is lacking, complicating the comparison of different studies and determination of whether a PDX experiment has produced evidence needed to consider a new therapy promising. We present consensus recommendations for assessment of PDX growth and antitumor activity, providing public access to a suite of tools for in vivo growth analyses. We expect that harmonizing PDX study design and analysis and assessing a suite of analytical tools will enhance information exchange and facilitate identification …