Digital Commons Network^™

Investigating The Role Of Betrayal Blindness Between High Betrayal Trauma And Dating Violence Among Young Mothers Maltreated As Children, Lauren Catherine Wallace

Theses and Dissertations

Young mothers experience greater rates of dating violence (DV) victimization and perpetration compared to their non-parenting, female peers as well as older mothers (Joly & Connolly, 2016). Child maltreatment is a salient predictor of DV victimization and perpetration (Li et al., 2019; Murphy et al., 2020). According to Betrayal Trauma Theory (BTT), child maltreatment perpetrated by a close loved one, such as a parent or primary caregiver, is defined as a high betrayal trauma (Freyd, 1996). Young mothers who experienced a high betrayal trauma may endorse betrayal blindness as a way to cope with abuse from their caregiver (Freyd & …

Post-Traumatic Stress Disorder Among Students In Gaza Strip After The Aggression 2022 According To Gender And Educational Level, Mohammed A. Shaheen, May Atiya

Journal of Educational and Psychological Studies

Abstract: The study aims to investigate the level of post-traumatic stress disorder among students in the Gaza Strip after the aggression 2022, and the differences in it according to gender and educational level. The study uses the descriptive method, by applying Trauma Scale (Davidson et al., 1996) after verifying the indications of validity and reliability of the tool. The sample consists of 390 male and female students, of whom 141 males and 249 females, 102 students from the upper basic stage, 164 from secondary schools, and 124 university students, were chosen using the available sample method. In order to process …

Emerging Cyber Risks & Threats In Healthcare Systems: A Case Study In Resilient Cybersecurity Solutions, Abdiaziz Abdi, Hajar Bennouri, Anthony Keane

Conference Papers

The exponential growth of digitalisation in healthcare and the ongoing threat of cybersecurity breaches are significant and cast a shadow over the industry’s progress. As the cost of data breaches reaches unprecedented levels, reaching an average of US$10.93 million in 2023 alone, and the frequency of attacks escalates, evidenced by a staggering 60% increase in phishing incidents between 2022 and 2023 reported by Smarttech247, Healthcare infrastructure is at a critical intersection. In this paper, we address the complex relationship between harnessing the potential of digital systems to improve and combating the escalating risks posed by cyber threats. The cyberattack on …

Development And Testing Of A Videogame Intervention For Improving The Health-Related Quality Of Life (Hrqol) Of Children With Cancer At A Tertiary Care Hospital In Pakistan: A Mixed Method Design, Sehrish Sajjad

Sigma Foundation for Nursing Research Grant Reports

The study aims to develop a videogame intervention for children (age 8-18 years) with cancer and test the clinical efficacy of the intervention with regards to cancer symptom management and HrQOL.

Reach, Rachel Immel

Theses

Reach is a 2D digitally animated short film that is dedicated to exploring the sacrifices that are made to achieve our dreams. The story of my graduate thesis film follows Moe, a subterrestrial bat-like creature that dreams of being able to see the sky for the first time. Feeling suffocated by his dark and cramped surroundings, he rushes toward the surface as soon as a busted rusty pipe provides what appears to be an opening to the surface. What he does not know is that he is venturing into danger that will change him forever. This project is inspired by …

S. Hayes V. Morris Houser

2024 Decisions

USDC for the Middle District of Pennsylvania

Burned Out By The Binary: How Misgendering Of Nonbinary Employees Contributes To Workplace Burnout, Sky Corby, Larry R. Martinez, Nicholas A. Smith, Kelly M. Hamilton, Mordeky C. Dullum

Psychology Faculty Publications and Presentations

We examine nonbinary employees’ experiences with misgendering in work contexts and draw from minority stress theory (Meyer, 2003) to understand the consequences of misgendering. Our findings from 29 semi-structured interviews with nonbinary individuals revealed that although being misgendered is a common and highly stressful experience (distal stressor), the emotional labor associated with anticipating and reacting to misgendering acts as an additional and more proximal stressor. Together, these stressors jointly contribute to all three components of employee burnout (emotional exhaustion, depersonalization, and reduced professional efficacy). We also identified support from coworkers and supervisors (in preventing and addressing misgendering) as important ameliorating …

Marketing In Higher Education: The Effects On The College Choice Experience Of First-Generation Latinx Students, David Cortez

Dissertations and Theses

The Latinx population in the United States has drastically increased over the last twenty years. During the same period, the number of first-generation Latinx students enrolling in higher education post-recession has also increased by as much as 1.5 million students. The expansion of the Latinx student population in Oregon has mirrored the national trend by exponentially increasing over the last 10 years. As the population of first-generation Latinx students grows, it becomes essential to explore the issues and barriers Latinx students face in making their college choices. Previous researchers have found that selecting the right institution is important to increase …

Serum From Patients With Cirrhosis Undergoing Liver Transplantation Induces Permeability In Human Pulmonary Microvascular Endothelial Cells, Michael Bokoch, Fengyun Xu, Krishna Govindaraju, Elliot Lloyd, Kyle Tsutsui, Rishi Kothari, Dieter Adelmann, Jérémie Joffre, Judith Hellman

Department of Anesthesiology Faculty Papers

INTRODUCTION: Patients with cirrhosis undergoing liver transplantation frequently exhibit systemic inflammation, coagulation derangements, and edema, indicating endothelial dysfunction. This syndrome may worsen after ischemia-reperfusion injury of the liver graft, coincident with organ dysfunction that worsens patient outcomes. Little is known about changes in endothelial permeability during liver transplantation. We hypothesized that sera from these patients would increase permeability in cultured human endothelial cells

METHODS: Adults with cirrhosis presenting for liver transplantation provided consent for blood collection during surgery. Sera were prepared at five time points spanning the entire operation. The barrier function of human pulmonary microvascular endothelial cells in culture …

Salvage Of A Kidney Transplant With A Mycotic Extrarenal Pseudoaneursym Using Donor Vessels, Audrey Horn, Kelli L. Summers, William Fuell, Adarsh Vijay, Hoonbae Jeon, Melissa Donovan, Kiara Tulla, Anil Paramesh

School of Medicine Faculty Publications

A 63-year-old male developed a mycotic pseudoaneurysm (MPA) two months after a renal transplant at the anastomotic site. He presented with uncontrolled hypertension and elevated creatinine. The pseudoaneurysm occurred at the anastomosis between the two donor renal arteries and the left external iliac artery. We describe a unique surgical reconstruction where the MPA was resected and the vasculature was reconstructed using deceased donor vessels. A deceased donor common iliac artery including superior gluteal and inferior gluteal branches were used as a jump graft from the contralateral common iliac artery to the two transplanted renal arteries. The external iliac artery was …

Exploring Evidentiary Approaches And Reform Potential In The Allies In Change Program For Abusive Intimate Partners, Julie Melissa Conner

Dissertations and Theses

This thesis examines the Allies in Change batterer intervention program, analyzing its curriculum components, alignment with evidence-based practices, unique features, limitations, and implications for domestic violence intervention. The study employs a qualitative mixed-methods approach, including curriculum textual analysis, word frequency count, a semi-structured interview with Chris Huffine, the curriculum author and program founder, and observation of a forty-hour domestic violence training provided for batterer intervention programs and facilitators.

The research begins by reviewing the literature on domestic violence intervention, highlighting the importance of evidence-based practices, cognitive behavioral techniques, and cultural responsiveness. It then conducts a textual analysis of the Allies …

Human Centered Approaches And Taxonomies For Explainable Artificial Intelligence, Helen Sheridan, Emma Murphy, Dympna O'Sullivan

Conference papers

Recent interest within the research community related to explainable artificial intelligence (XAI) has led to a profuse amount of literature on the subject. Those who wish to tackle the domain from an HCI focus may be presented with overwhelming material, most of which does not pertain to human aspects of XAI. Taxonomies can serve to categorize a subject into topic areas and distill content into an overview of the field. This late breaking work intends to help those within the HCI community with a focus on XAI to understand relevant aspects of human centered XAI. We also present a taxonomy …

Task And Stimulus Coding In The Multiple-Demand Network, Sneha Shashidhara, Moataz Assem, Matthew F Glasser, John Duncan

2020-Current year OA Pubs

In the human brain, a multiple-demand (MD) network plays a key role in cognitive control, with core components in lateral frontal, dorsomedial frontal and lateral parietal cortex, and multivariate activity patterns that discriminate the contents of many cognitive activities. In prefrontal cortex of the behaving monkey, different cognitive operations are associated with very different patterns of neural activity, while details of a particular stimulus are encoded as small variations on these basic patterns (Sigala et al, 2008). Here, using the advanced fMRI methods of the Human Connectome Project and their 360-region cortical parcellation, we searched for a similar result in …

A "Prime And Expand" Strategy Using The Multifunctional Fusion Proteins To Generate Memory-Like Nk Cells For Cell Therapy, Niraj Shrestha, Michelle Becker-Hapak, Mark Foster, Ethan Mcclain, Melissa M Berrien-Elliott, Todd A Fehniger, Et Al.

2020-Current year OA Pubs

Adoptive cellular therapy (ACT) using memory-like (ML) natural killer (NK) cells, generated through overnight ex vivo activation with IL-12, IL-15, and IL-18, has shown promise for treating hematologic malignancies. We recently reported that a multifunctional fusion molecule, HCW9201, comprising IL-12, IL-15, and IL-18 domains could replace individual cytokines for priming human ML NK cell programming ("Prime" step). However, this approach does not include ex vivo expansion, thereby limiting the ability to test different doses and schedules. Here, we report the design and generation of a multifunctional fusion molecule, HCW9206, consisting of human IL-7, IL-15, and IL-21 cytokines. We observed > 300-fold …

O-Glcnacylation Of Mitf Regulates Its Activity And Cdk4/6 Inhibitor Resistance In Breast Cancer, Yi Zhang, Shuyan Zhou, Yan Kai, Ya-Qin Zhang, Changmin Peng, Zhuqing Li, Muhammad Jameel Mughal, Belmar Julie, Xiaoyan Zheng, Junfeng Ma, Cynthia X Ma, Min Shen, Matthew D Hall, Shunqiang Li, Wenge Zhu

2020-Current year OA Pubs

Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhibitors (CDK4/6i), such as palbociclib, remains a substantial challenge in clinical settings. Using high-throughput combinatorial drug screening and genomic sequencing, we find that the microphthalmia-associated transcription factor (MITF) is activated via O-GlcNAcylation by O-GlcNAc transferase (OGT) in palbociclib-resistant breast cancer cells and tumors. Mechanistically, O-GlcNAcylation of MITF at Serine 49 enhances its interaction with importin α/β, thus promoting its translocation to nuclei, where it suppresses palbociclib-induced senescence. Inhibition of MITF or …

Exclusion Disguised As Access: A Critical Discourse Analysis Of Postsecondary Disability Service Websites, Lavonne Ciezadlo Kopca

Theses and Dissertations

College students with disabilities are an overlooked minority population. However, they comprise an ever-increasing student population in postsecondary institutions. Yet students with disabilities do not persist or graduate at rates similar to their able-bodied peers. People with disabilities have historically been viewed as a low-status group and have been excluded from various social, educational, and economic benefits of citizenship. This study used a critical theoretical lens of social dominance theory to explore ways that higher education may be complicit in perpetuating discrimination and inequities through policies or discourse found in the content of student disability and diversity office websites. Key …

Rectal Cancer Treatment: Sexual Function Is Not The Sole Determinant Of Quality Of Life, Sarah M. Popek

Biomedical Sciences ETDs

Colorectal cancer is the third most common cancer. Rectal cancer patients face genitourinary dysfunction, impacting physical, psychological, and social well-being. This study examined the prevalence of sexual dysfunction in rectal cancer patients to assess the impact of sexual dysfunction on quality of life (QoL).

This mixed method study included 19 completing the survey portion and 10 completing an interview, evenly split between men and women, and those with and

without a stoma. Most experienced significant sexual dysfunction, and discussion of sexual function was rare. Quality of life scores were high. Themes from the interviews included (1) the relationship between the …

Valorization Of Seafood Waste For Food Packaging Development, Zhijing Zhan, Yiming Feng, Jikai Zhao, Mingyu Qiao, Qing Jin

School of Earth, Environmental, & Marine Sciences Faculty Publications

Packaging plays a crucial role in protecting food by providing excellent mechanical properties as well as effectively blocking water vapor, oxygen, oil, and other contaminants. The low degradation of widely used petroleum-based plastics leads to environmental pollution and poses health risks. This has drawn interest in renewable biopolymers as sustainable alternatives. The seafood industry generates significant waste that is rich in bioactive substances like chitin, chitosan, gelatins, and alginate, which can replace synthetic polymers in food packaging. Although biopolymers offer biodegradability, biocompatibility, and non-toxicity, their films often lack mechanical and barrier properties compared with synthetic polymer films. This comprehensive review …

Use Of Flipped Classroom Learning Activities In Nursing: A Basic Qualitative Study, Tamara J. Steele

Dissertations

This study aimed to explore the experiences of nurse educators using flipped classroom methods with learning activities proven to be successful in students' achievement of learning outcomes. Specifically, it aimed to identify the learning activities that nurse educators have found to be most successful in terms of student achievement of learning outcomes. An additional focus of the study was to identify the flipped classroom and learning activity evaluation methods used by nurse educators and examine how those evaluation results were used to further enhance future nursing courses. An important gap in the extant literature related to a lack of in-depth …

The Parthenon, July 03, 2024, Evan Green, Sarah Davis, Baylee Parsons, Scott Price, Abigail Cutlip, Maggie Gibbs

The Parthenon

No abstract provided.

Rehabilitation After Scapular Fractures, Andrea Lopes Sauers, Rita Ator, Jaime González

Physical Therapy Faculty Publications

Scapular fractures are uncommon, and published guidelines on the rehabilitation of scapular fractures are limited. This chapter summarizes the current concepts that can assist decision-making for rehabilitating patients following scapular fracture. The STAR-shoulder and the modified algorithm for scapular dysfunction are viable frameworks to aid decision-making and can aptly guide rehabilitation after scapular fracture. The selection of the appropriate rehabilitation strategies after scapular fracture requires a close understanding of the mechanism of injury, type of management, existing comorbidities, and associated injuries. Thus, communication between the physical therapist and the surgeon or physician is vital for quality care and positive patient …

The Protective Efficacy Of A Sars-Cov-2 Vaccine Candidate B1351v Against Several Variant Challenges In K18-Hace2 Mice, Jie Yang, Huifen Fan, Anna Yang, Wenhui Wang, Xin Wan, Fengjie Lin, Dongsheng Yang, Jie Wu, Kaiwen Wang, Wei Li, Qian Cai, Lei You, Deqin Pang, Jia Lu, Changfu Guo, Jinrong Shi, Yan Sun, Xinguo Li, Kai Duan, Shuo Shen, Shengli Meng, Jing Guo, Zejun Wang

Faculty, Staff and Student Publications

The emergence of SARS-CoV-2 variants of concern (VOCs) with increased transmissibility and partial resistance to neutralization by antibodies has been observed globally. There is an urgent need for an effective vaccine to combat these variants. Our study demonstrated that the B.1.351 variant inactivated vaccine candidate (B.1.351V) generated strong binding and neutralizing antibody responses in BALB/c mice against the B.1.351 virus and other SARS-CoV-2 variants after two doses within 28 days. Immunized K18-hACE2 mice also exhibited elevated levels of live virus-neutralizing antibodies against various SARS-CoV-2 viruses. Following infection with these viruses, K18-hACE2 mice displayed a stable body weight, a high survival …

Office Of Research, Economic Engagement And Outreach Update, July 3, 2024, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Sociology Between The Gaps Volume 9 (2024)

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

The Relationship Between Operating Efficiency, Credit Score, And Small Business Sustainability, Garfield Henry

Walden Dissertations and Doctoral Studies

The first 5 years of a small business (SB) life are critical because 50-60% fail. SB leaders are concerned about the inability of many SBs to attain sustainability within 5 years, given their pivotal role in owner and community financial viability. Grounded in the resource-based view theory, the purpose of this quantitative correlational study was to examine the relationship between SB operating efficiency, credit score, and sustainability. Secondary data for 211 closed and 211 companies still operating from 2013 to 2023 were collected from the Data Axle website for analysis. The results of the binary logistic regression were significant, X2 …

Relationship Between Respect, Trust, And Turnover Intentions, Christina Love Harmon

Walden Dissertations and Doctoral Studies

Leaders in the U.S. federal government are concerned with employee intent to leave, as it is the number one predictor of actual employee turnover. Grounded in social exchange theory, the purpose of this quantitative ex-post facto correlation study was to examine the relationship between social exchange and employee intent to leave. The participants were 256 employees from all agencies within the U.S. federal government who completed the 2022 Federal Employee Viewpoint Survey, including the Intent to Leave Scale. The results of the multinomial logistics regression were significant, χ² (4) = 87.875, p = <.001. In the final model, two predictors were significant, respect for department leaders, χ² (12) = 43.631, p = <.001, and trust in direct supervisor, χ² (12) = 32.513, p = 001. A key recommendation is for business leaders to model positive attitudes and behaviors by fostering a culture of trust, respect, and integrity to contribute to employee satisfaction and retention significantly. The implications for positive social change include the potential to retain valued employees who are committed to achieving organizational goals and improving productivity for organizational success

High Sugar Diet Alters Immune Function And The Gut Microbiome In Juvenile Green Iguanas (Iguana Iguana), Kwanho C. Ki, Erin L. Lewis, Elizabeth Wu, Francis J. Oliaro, Lise M. Aubry, Charles R. Knapp, Karen M. Kapheim, Dale Denardo, Susannah S. French

Biology Faculty Publications

The present work aimed to study whether a high sugar diet can alter immune responses and the gut microbiome in green iguanas. Thirty-six iguanas were split into four treatment groups using a 2x2 design. Iguanas received either a sugar-supplemented diet or a control diet, and either a lipopolysaccharide (LPS) injection or a phosphate-buffered saline (PBS) injection. Iguanas were given their respective diet treatment through the entire study (~3 months) and received a primary immune challenge 1 and 2 months into the experiment. Blood samples and cloacal swabs were taken at various points in the experiment and used to measure changes …

Novel Antivirals Unveiled Against Acute And Persistent Coxsackievirus B3 Infection Via Rapid Screening, Maria Del Mar Villanueva Guzman

Master's Theses

Enteroviruses cause 10 to 15 million infections annually in the United States, and Coxsackievirus B3 is one of the most commonly reported. Coxsackieviruses may become persistent, characterized as a viral infection that is not cleared from host cells and that generates a continuous infection. Patients who develop persistent CVB3 infection may not respond to the same antivirals as an acute infection, which may be detrimental. Therefore, there is a need for broad-range antiviral drugs to combat acute and persistent CVB3 infection, as there is no well-accepted treatment available. We developed a model system to study persistent CVB3 using a pancreatic …

Novel Antivirals Unveiled Against Acute And Persistent Coxsackievirus B3 Infection Via Rapid Screening, Maria Del Mar Villanueva Guzman

Master's Theses

Enteroviruses cause 10 to 15 million infections annually in the United States, and Coxsackievirus B3 is one of the most commonly reported. Coxsackieviruses may become persistent, characterized as a viral infection that is not cleared from host cells and that generates a continuous infection. Patients who develop persistent CVB3 infection may not respond to the same antivirals as an acute infection, which may be detrimental. Therefore, there is a need for broad-range antiviral drugs to combat acute and persistent CVB3 infection, as there is no well-accepted treatment available. We developed a model system to study persistent CVB3 using a pancreatic …

Depression Screening For Nursing Home Residents, Victor Chukwuocha

Walden Dissertations and Doctoral Studies

The project focused on depression among nursing home residents, an underrecognized and undertreated condition that affects quality of life. Few studies have been conducted on the subject of depression screening for nursing home residents, resulting in a lack of understanding among the nursing profession on managing specific conditions. At a nursing home, there was a need to address depression. The practice-focused question used in this project addressed the process of the translation of evidence to develop a staff education project for depression to enhance the knowledge of nurses working with nursing home residents. The project followed an evidence-based approach to …