Digital Commons Network^™

Predictive Value Of Has-Bled And Hemorr2hages Bleeding Risk Scores After Percutaneous Coronary Intervention, Ianis Doomun, Daphné Doomun, Sara Schukraft, Diego Arroyo, Selma T Cook, Tibor Huwyler, Jean-Jacques Goy, Jean-Christophe Stauffer, Mario Togni, Serban Puricel, Stéphane Cook

The Texas Heart Institute Journal

BACKGROUND: Various scoring systems have been developed to assess the risk of bleeding in medical settings. HAS-BLED and HEMORR2HAGES risk scores are commonly used to estimate bleeding risk in patients receiving anticoagulation for atrial fibrillation, but data on their predictive value in patients undergoing percutaneous coronary intervention (PCI) are limited.

METHODS: This study evaluated and compared the predictive abilities of the HAS-BLED and HEMORR2HAGES bleeding risk scores in all-comer patients undergoing PCI. The PARIS score, specifically designed for patients undergoing PCI, was used as a comparator. The scores were calculated at baseline and compared with the occurrence of events during …

Community-Based Participatory Obesity Prevention Interventions In Rural Communities: A Scoping Review, Saagar Dhanjani, Haley Allen, Beatriz Varman, Chishinga Callender, Jayna M Dave, Debbe Thompson

Library Staff Publications

Child obesity is a worldwide public health concern. In America, children from rural areas have greater odds of obesity in comparison to those from urban areas. Community-engaged research is important for all communities, particularly under-represented communities. This paper reports the results of a scoping review investigating community-engaged research in obesity prevention programs tested with school-aged children in rural America. A literature search of Medline Ovid was conducted to identify interventions reporting the results of obesity prevention interventions that promoted a healthy diet or physical activity (PA) behaviors to school-age children in rural communities of the United States (US). After title …

Loncastuximab Tesirine In The Treatment Of Relapsed Or Refractory Diffuse Large B-Cell Lymphoma, Luis Miguel Juárez-Salcedo, Santosh Nimkar, Ana Maria Corazón, Samir Dalia

Student Publications

Currently, a significant percentage of patients with DLBCL are refractory or relapse after a first line of immunochemotherapy. Second relapses after autologous stem cell transplantation or chimeric antigen receptor T-cell therapies present few treatment options and do not yield good results. New molecules have entered the immunotherapy arsenal. Loncastuximab tesirine comprises a humanized anti-CD19 monoclonal conjugated antibody, which consists of an anti-CD19 antibody and cytotoxic alkylating agent, SG3199. Several studies have proven its efficacy in the treatment of refractory cases of DLBCL with a good safety profile, with the main adverse effects being neutropenia, thrombopenia, and liver enzyme involvement. In …

Barriers To And Facilitators Of Implementing Colorectal Cancer Screening Evidence-Based Interventions In Federally Qualified Health Centers: A Qualitative Study, Emanuelle M Dias, Joe R Padilla, Paula M Cuccaro, Timothy J Walker, Bijal A Balasubramanian, Lara S Savas, Melissa A Valerio-Shewmaker, Roshanda S Chenier, Maria E Fernandez

Faculty, Staff and Student Publications

Background: There is an urgent need to increase colorectal cancer screening (CRCS) uptake in Texas federally qualified health centers (FQHCs), which serve a predominantly vulnerable population with high demands. Empirical support exists for evidence-based interventions (EBIs) that are proven to increase CRCS; however, as with screening, their use remains low in FQHCs. This study aimed to identify barriers to and facilitators of implementing colorectal cancer screening (CRCS) evidence-based interventions (EBIs) in federally qualified health centers (FQHCs), guided by the Consolidated Framework for Implementation Research (CFIR).

Methods: We recruited employees involved in implementing CRCS EBIs (e.g., physicians) using data from a …

Identification Of Blood Meals In Field Collected Culex Pipiens, Anopheles Sacharovi And Culex Tritaeniorhynchus (Diptera: Culicidae) Using The Elisa Method, Fatma Bursali, Gi̇zem Anti̇ka, Sare İlknur Yavaşoğlu, Fati̇h Mehmet Şi̇mşek

Turkish Journal of Zoology

Information obtained about the blood feeding behavior of mosquito populations in nature is important for understanding their vectorial capacity and evaluating their potential role in the transmission of vector-borne diseases. This study investigated the feeding patterns of Culex pipiens, Anopheles sacharovi and Culex tritaeniorhynchus by using ELISA method. A total of 435 blood-fed females were collected from the Aegean and Mediterranean regions of Türkiye between May 2021-September 2023. The types and numbers of potential domestic animal hosts were recorded in each village. Of the 372 blood meals tested, 348 gave a single host positive result mainly on bovine and human, …

Costs And Impact Of Disease In Adults With Sickle Cell Disease: A Pilot Study, Sophie Lanzkron, Nicole Crook, Joanne Wu, Sarah Hussain, Randall G. Curtis, Derek Robertson, Judith R. Baker, Diane Nugent, Amit Soni, Jonathan C. Roberts, Megan M. Ullman, Julie Kanter, Michael B. Nichol

Cardeza Foundation for Hematologic Research

We assessed the feasibility to estimate illness burden in adults with SCD, investigated factors associated with health-related quality of life (HRQoL), and estimated societal burden. We recruited 32 participants and collected data on fatigue, HRQoL, and work productivity and activity impairment via patient survey. Health care utilization was abstracted for the 12 months before enrollment using medical chart review. Mean age was 36.7 years; 84.4% of participants had hemoglobin SS or Sβthal0 disease, and 81.3% reported chronic pain (experiencing pain on ≥3 days per week in the past 6 months). Mean EQ-5D-3L visual analogue scale score was 63.4 and the …

Discordant Prenatal Cell-Free Dna Screening Vs. Diagnostic Results Of Sex Chromosome Aneuploidies: Implications For Newborn Screening And Genetic Counseling, Susan Howell, Shanlee M. Davis, Billie Carstens, Mary Haag, Judith L. Ross, Nicole R. Tartaglia

Department of Pediatrics Faculty Papers

Sex chromosome aneuploidies (SCAs) collectively occur in 1 in 500 livebirths, and diagnoses in the neonatal period are increasing with advancements in prenatal and early genetic testing. Inevitably, SCA will be identified on either routine prenatal or newborn screening in the near future. Tetrasomy SCAs are rare, manifesting more significant phenotypes compared to trisomies. Prenatal cell-free DNA (cfDNA) screening has been demonstrated to have relatively poor positive predictive values (PPV) in SCAs, directing genetic counseling discussions towards false-positive likelihood rather than thoroughly addressing all possible outcomes and phenotypes, respectively. The eXtraordinarY Babies study is a natural history study of children …

Adults With Avoidant Attachment Styles And Their Online Dating Experien, Amber Mae Nelson

Walden Dissertations and Doctoral Studies

Adult attachment style can influence how individuals communicate with each other and how they deal with conflict, both of which may influence the formation and maintenance of romantic relationships. Research suggested, that attachment style influenced the level of relationship security individuals experience and the level of intimacy in which they are comfortable engaging. The convenience and popularity of online dating may present unique struggles and benefits for adults with avoidant attachment styles; exploring their online dating experiences may provide insight into the benefits and pitfalls as avoidant individuals pursue romantic relationships. The purpose of this qualitative study was to explore …

Understanding The Perception Of Risk For Heart Disease In African American Women, Erica Hudson

Walden Dissertations and Doctoral Studies

Heart disease is a serious health condition and is one of the leading causes of death in the United States. African American women have the highest mortality rate from heart disease compared to any other racial group. The purpose of this research study was to assess knowledge of heart disease, by investigating two constructs of the health belief model: perceived susceptibility and perceived severity. A correlation design was used to analyze survey data from African American women from age 40 to 55 from the Atlanta, Georgia area. The participants completed the assessments on survey monkey. The assessments included a demographic …

Perceived Stress, Social Media Usage, And Sleep Quality In United States Adults, Justine P. Scott

Walden Dissertations and Doctoral Studies

The purpose of this quantitative study was to explore the intricate connections among perceived stress, sleep quality, and social media usage metrics, challenging prior assumptions by highlighting social media as a noteworthy stress coping mechanism. The research aimed to understand the relationship between sleep quality, perceived stress, and the frequency and quality of social media use, guided by the biopsychosocial model as the theoretical framework.The study involved adults aged 20-65. A questionnaire incorporated four validated instruments to assess these variables: the Epworth Sleepiness Scale (ESS), Internet Addiction Diagnostic Questionnaire (IADQ), Perceived Stress Scale (PSS), and Social Media Quality Measure (SMQM). …

Prothrombin Time (Pt), Activated Partial Thromboplastin Time (Aptt), Fibrinogen, And D-Dimer In Coronavirus Disease 2019 Outcome, Fredy Wirya Atmaja, Sri Suryo Adiyanti, Diyah Kristanty, Surya Dwira, Kusmardi Kusmardi

Indonesian Journal of Medical Chemistry and Bioinformatics

COVID-19, caused by SARS-CoV-2 has been reported to be associated with coagulopathy and DIC. This study aimed to investigate the profiles and differences of PT, APTT, fibrinogen, and D-dimer in COVID- 19 outcome. This retrospective cohort was conducted at Central Laboratory Clinical Pathology Department of dr. Cipto Mangunkusumo Hospital from July – December 2020. Demographic, clinical, and laboratory data were extracted from EHR and compared between poor and good outcome. Ninety-seven subjects were confirmed positive COVID-19, 45 of whom (46.4%) were in poor outcome group, while 52 subjects (53.6%) were in good outcome group. Median of PT 11.0” (9.7-28.3), APTT …

Understanding Hope From Indian Young Adults’ Perspective, Mimansa Khanduri, Ketoki Mazumdar

The Qualitative Report

Despite the long-understood importance of Hope in the lives of individuals, few studies have investigated how Hope is understood from an Indian perspective. Furthermore, the focus on understanding the interpretations and experiences of Hope in the young adult population has been low. The current paper explores the phenomenon of Hope from Indian young adults’ perspective. The sample consisted of 10 participants, who were in the age range of 21 to 22 years and were pursuing their undergraduate or postgraduate studies. The study utilized in-depth interviews to understand the experiences and perspectives of Hope in the participants. Data were analyzed through …

The Effects Of Physical Accessibility And Subjective Accessibility On Grocery Shopping Behaviors In Oakland, California, Huijun Tan

Dissertations and Theses

Existing studies underscore the complexity of urban accessibility, defined by a range of factors, including the city's physical layout and infrastructure as well as the subjective perceptions and experiences of its inhabitants. As urban areas continue to grow and diversify, gaining a comprehensive understanding of these varied interactions is imperative. This broader context highlights the necessity of investigating the interplay between physical and subjective accessibility, aiming to illuminate the specific challenges and opportunities faced by these communities in accessing necessary services. This study explored the relationship between physical and subjective accessibility and their consequential impact on grocery shopping behaviors among …

The Multifaceted Role Of Neutrophils In Nsclc In The Era Of Immune Checkpoint Inhibitors, Shucheng Miao, Bertha Leticia Rodriguez, Don L Gibbons

Faculty, Staff and Student Publications

Lung cancer is the most common cause of cancer-related death in both males and females in the U.S. and non-small-cell lung cancer (NSCLC) accounts for 85%. Although the use of first- or second-line immune checkpoint inhibitors (ICIs) exhibits remarkable clinical benefits, resistance to ICIs develops over time and dampens the efficacy of ICIs in patients. Tumor-associated neutrophils (TANs) have an important role in modulating the tumor microenvironment (TME) and tumor immune response. The major challenge in the field is to characterize the TANs in NSCLC TME and understand the link between TAN-related immunosuppression with ICI treatment response. In this review, …

Tsg-6+ Cancer-Associated Fibroblasts Modulate Myeloid Cell Responses And Impair Anti-Tumor Response To Immune Checkpoint Therapy In Pancreatic Cancer, Swetha Anandhan, Shelley Herbrich, Sangeeta Goswami, Baoxiang Guan, Yulong Chen, Marc Daniel Macaluso, Sonali Jindal, Seanu Meena Natarajan, Samuel W Andrewes, Liangwen Xiong, Ashwat Nagarajan, Sreyashi Basu, Derek Ng Tang, Jielin Liu, Jimin Min, Anirban Maitra, Padmanee Sharma

Faculty, Staff and Student Publications

Resistance to immune checkpoint therapy (ICT) presents a growing clinical challenge. The tumor microenvironment (TME) and its components, namely tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs), play a pivotal role in ICT resistance; however, the underlying mechanisms remain under investigation. In this study, we identify expression of TNF-Stimulated Factor 6 (TSG-6) in ICT-resistant pancreatic tumors, compared to ICT-sensitive melanoma tumors, both in mouse and human. TSG-6 is expressed by CAFs within the TME, where suppressive macrophages expressing Arg1, Mafb, and Mrc1, along with TSG-6 ligand Cd44, predominate. Furthermore, TSG-6 expressing CAFs co-localize with the CD44 expressing macrophages in the TME. …

Radiation Therapy With Or Without Cisplatin For Local Recurrences Of Endometrial Cancer: Results From An Nrg Oncology/Gog Prospective Randomized Multicenter Clinical Trial, Ann H Klopp, Danielle Enserro, Matthew Powell, Marcus Randall, Julian C Schink, Robert S Mannel, Laura Holman, David Bender, Christina L Kushnir, Floor Backes, Susan L Zweizig, Steven Waggoner, Kristin A Bradley, Lana Desouza Lawrence, Parviz Hanjani, Christopher J Darus, William Small, Higinia R Cardenes, Jonathan M Feddock, David S Miller

Faculty, Staff and Student Publications

Purpose: Pelvic recurrence is a frequent pattern of relapse for women with endometrial cancer. A randomized trial compared progression-free survival (PFS) after treatment with radiation therapy alone as compared with concurrent chemotherapy.

Materials and methods: Between February 2008 and August 2020, 165 patients were randomly assigned 1:1 to receive either radiation treatment alone or a combination of chemotherapy and radiation treatment. The primary objective of this study was to determine whether chemoradiation therapy was more effective than radiation therapy alone at improving PFS.

Results: The majority of patients had low-grade (1 or 2) endometrioid histology (82%) and recurrences confined to …

Correction: A Microcosting Approach For Planning And Implementing Community-Based Mental Health Prevention Programs: What Does It Cost?, Sharmily Roy, Henry Shelton Brown, Lisa Sanger Blinn, Sarah Carter Narendorf, Jane E Hamilton

Faculty, Staff and Student Publications

No abstract provided.

Students With Intensive Needs In An Inclusive Education System: A Literature Review, Mohammad Idrees Naeemy, Hiroki Yoneda

Journal of ICSAR

Educating students with various types and degrees of disabilities in regular classrooms remains challenging. Despite the global agenda and push for inclusive education, students with disabilities, particularly those with multiple and severe disabilities, are still being educated in segregated environments. In this qualitative study of peer-reviewed research literature, we aim to understand students with intensive needs (SINs), their current situation in inclusive education systems in developed and developing countries, and the best approaches to how they are being or should be educated in inclusive education systems. The results indicate that students who experience severe challenges in their physical, intellectual, developmental, …

Esther Reid V. Rebath, L.C. : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

On appeal from the Fourth Judicial District Court, Utah County Honorable Christine Johnson, District Court No. 1200400795

Sean Nobmann Attorney for Plaintiffs/Appellants

S. Spencer Brown (13157) STRONG AND HANNI Attorneys for Defendant/Appellee

Ragopathies And The Rising Influence Of Raggtpases On Human Diseases, Irene Sambri, Marco Ferniani, Andrea Ballabio

Duncan NRI Faculty and Staff Publications

RagGTPases (Rags) play an essential role in the regulation of cell metabolism by controlling the activities of both mechanistic target of rapamycin complex 1 (mTORC1) and Transcription factor EB (TFEB). Several diseases, herein named ragopathies, are associated to Rags dysfunction. These diseases may be caused by mutations either in genes encoding the Rags, or in their upstream regulators. The resulting phenotypes may encompass a variety of clinical features such as cataract, kidney tubulopathy, dilated cardiomyopathy and several types of cancer. In this review, we focus on the key clinical, molecular and physio-pathological features of ragopathies, aiming to shed light on …

Sexual And Reproductive Health Education: A Case Study At Pembina Pekanbaru Special School, Arif Prawira, Imas Diana Aprilia

Journal of ICSAR

The easy access to inappropriate content through digital media presents a particular challenge in education, particularly in special education. This research aims to get a better understanding of sexual and reproductive health education at the Pembina Pekanbaru Special School, Indonesia. The method of this research uses a qualitative method, and the data is collected through interviews with 4 teachers and 2 parents of students. The results indicate that sexual and reproductive health education at the school is still limited to aspects of the content of human anatomy and physiology. However, other aspects such as sexual and reproductive health are not …

The Effect Of "Kis" (Social Interaction Communication) Application On The Augmentative Alternative Communication To Improve Communication For Down Syndrome Students, Tita Sundari, Imas Diana Aprilia

Journal of ICSAR

This research develops AAC for students with Down syndrome using the "KIS" application media. The purpose of making this media is to help students with Down syndrome who have difficulty communicating. The application is designed using symbols to learn to understand and express themselves using predetermined symbols. This study used an experimental, single-subject research (SSR) approach with an A-B-A design. the subject in this study was one of the Down syndrome students with communication barriers. The target behavior of the research is communication skills. Data collection techniques are obtained by observation, and action tests. The data analysis used is a …

Training System For Sne Teachers At Elementary, Middle, And High Schools: A Qualitative Analysis Of The Case Studies Content, Jieping Ou, Masayoshi Tsuge, Keiko Kumagai, Ami Sambai, Shoko Miyamoto, Shinji Okazaki, Fumiyuki Noro, Michio Kojima, Hiroki Yoneda

Journal of ICSAR

Conventional lecture-style training ends up being biased toward teaching basic theoretical knowledge, and some issues have been identified. Therefore, it is necessary to construct an effective training system that could be used by in-service teachers in actual teaching practice. This case study relates to the issues encountered in creating individualized teaching plans (ITP) and teaching practices for students with special education needs enrolled in regular schools. This study analyzed 10 cases by using the qualitative data analysis software MAXQDA. Consequently, a more positive and accurate study of the students’ conditions was conducted, and diverse opinions were elicited, including exchanges of …

Coping Strategies In Mothers Of Children With Autism: Insight From F-Copes, Siti Musayaroh, Reza Febri Abadi, Muslihah Muslihah, Anna Miftahul Jannah, Rr Farhana Rizqi Karina, Sayidatul Maslahah

Journal of ICSAR

Parenting children with autism triggers stress for parents, especially mothers. Every mother needs to have coping strategies to overcome the stress experienced during parenting. This study aims to examine coping strategies in mothers of children with autism. A total of 50 mothers of children with autism participated in this research by filling out the F-COPES scale questionnaire, which consists of 5 subscales: acquiring social support, reframing, seeking spiritual support, mobilizing family support, and passive appraisal. Data was analyzed using Pearson Correlation analysis and Multiple Regression Analysis. The results show that the F-COPES scores of mothers of children with autism are …

Universal Design Learning: Rehabilitation And Inclusive Education In Multidisciplinary Perspective For Inclusive Development, Dewi Anggraini, Yohanes Subasno

Journal of ICSAR

Every person has the right to access educational services, considering that education is one of the most important elements of life in society. More specifically, education can be understood as one of the capitals used by individuals to change the order of their lives in the arena of life in various aspects. The paper aims to show the relevance of rehabilitation for persons with disabilities and inclusive education as a way to achieve inclusive development in the future through Universal Design Learning (UDL). UDL ensures the system of education should focus on the right to quality education for every child, …

Designing Assessment Instruments For Mild Intellectual Disability Students On Gardening Product Marketing, Teti Ratnawulan, Fajar Indra Septiana, Hendri Abdul Qohar, Ranti Novianti, Ani Nurdiani

Journal of ICSAR

The study focuses on understanding the challenges, capabilities, and requirements of students with mild intellectual disabilities in marketing skills related to vegetable gardening. It aims to create a suitable learning assessment tool for these students. The researcher observed that teachers lacked a specific assessment instrument for evaluating the marketing of garden products. Consequently, a teacher improvised a self-made assessment. The research methodology employed a descriptive approach within a qualitative framework. Data collection methods included observation, interviews, documentation analysis, Focus Group Discussions (FGDs), and validation. Validation involved multiple stakeholders: a class teacher, a vice head of curriculum, a vocational teacher, and …

“Parenting” As The Enhancer Of Subjective-Educative Experiences: Case Study On Parental Process Of Children With Intellectual Disability, Sopingi Sopingi

Journal of ICSAR

From adults’ learning perspectives, parenting children with intellectual disabilities is considered a social reality interestingly researched, particularly related to the challenges and experiences during the parenting process encountered by parents who lack knowledge and understanding of intellectual disabilities. This research aims to (1) describe the configuration of parenting challenges in-depth and (2) explore the subjective-educative experiences derived from the challenges. This research was conducted using a qualitative approach with a phenomenological method. The data was derived from in-depth interviews with parents of children with moderate intellectual disability. The data were analyzed following the stages of the phenomenological method consisting of …

The Voice: A Case Study On Parental Perspectives In Empowering Learners With Special Educational Needs Through Performing Arts Education, Suhaila Mohamad

Journal of ICSAR

This case study explores parental perspectives on empowering learners with Special Educational Needs (SEN) through performing arts education. It investigates the advantages of performing arts education for learners with SEN and offers recommendations for improvement. It also focuses on understanding parental views on the role of performing arts education in empowering learners with SEN and the benefits derived from such programs. This case study employs a mixed-methods research design, combining quantitative and qualitative approaches through surveys and interviews. The survey method involves administering structured questionnaires to gather numerical data, while interviews provide in-depth insights into parents' perspectives. Triangulation is employed …

Phase Ib Study Of Unesbulin (Ptc596) Plus Dacarbazine For The Treatment Of Locally Recurrent, Unresectable Or Metastatic, Relapsed Or Refractory Leiomyosarcoma, Brian A Van Tine, Matthew A Ingham, Steven Attia, Christian F Meyer, John D Baird, Esther Brooks-Asplund, Dhiren D'Silva, Ronald Kong, Anthony Mwatha, Kylie O'Keefe, Marla Weetall, Robert Spiegel, Gary K Schwartz

2020-Current year OA Pubs

PURPOSE: This multicenter, single-arm, open-label, phase Ib study was designed to determine the recommended phase II dose (RP2D) and to evaluate the safety and preliminary efficacy of unesbulin plus dacarbazine (DTIC) in patients with advanced leiomyosarcoma (LMS).

PATIENTS AND METHODS: Adult subjects with locally advanced, unresectable or metastatic, relapsed or refractory LMS were treated with escalating doses of unesbulin orally twice per week in combination with DTIC 1,000 mg/m

RESULTS: Unesbulin 300 mg administered orally twice per week in combination with DTIC 1,000 mg/m

CONCLUSION: Unesbulin 300 mg twice per week plus DTIC 1,000 mg/m

On Emily Dickinson, Katelyn Confer

2024 Symposium

The following paper will explore the relationship between Emily Dickinson’s poetry, the circumstances of her life, and the historical context in which she lived to glean an understanding of how her mental health influenced her work. Selected poems by Dickinson will be reviewed and analyzed, along with a brief overview of nineteenth century attitudes towards female mental health with a particular emphasis on the medical diagnosis of female hysteria.