Digital Commons Network^™

Benchmarking Lung Cancer Screening Programmes With Adaptive Screening Frequency Against The Optimal Screening Schedules Derived From The Engage Framework: A Comparative Microsimulation Study, Mehdi Hemmati, Sayaka Ishizawa, Rafael Meza, Edwin Ostrin, Samir M Hanash, Mara Antonoff, Andrew J Schaefer, Martin C Tammemägi, Iakovos Toumazis

Faculty, Staff and Student Publications

Background: Lung cancer screening recommendations employ annual frequency for eligible individuals, despite evidence that it may not be universally optimal. The impact of imposing a structure on the screening frequency remains unknown. The ENGAGE framework, a validated framework that offers fully dynamic, analytically optimal, personalised lung cancer screening recommendations, could be used to assess the impact of screening structure on the effectiveness and efficiency of lung cancer screening.

Methods: In this comparative microsimulation study, we benchmarked alternative clinically relevant structured lung cancer screening programmes employing a fixed (annual or biennial) or adaptive (start with annual/biennial screening and then switch to …

Accelerated Tumor Progression After Covid-19 Infection In Patients With Glioblastoma: A Retrospective Case-Control Study, Timothy A Gregory, Stephanie R Knight, Ashley E Aaroe, Kaitlin N Highsmith, Zachary C Janatpour, Barbara J O'Brien, Nazanin K Majd, Monica E Loghin, Chirag B Patel, Shiao-Pei Weathers, Vinay K Puduvalli, Carlos Kamiya-Matsuoka

Faculty, Staff and Student Publications

Background: We observed rapid tumor progression following COVID-19 infection among patients with glioblastoma and sought to systematically characterize their disease course in a retrospective case-control study.

Methods: Using an institutional database, we retrospectively identified a series of COVID-19-positive glioblastoma cases and matched them by age and sex 1:2 to glioblastoma controls who had a negative COVID-19 test during their disease course. Demographic and clinical data were analyzed. Hyperprogression was defined using modified response evaluation criteria in solid tumors criteria. Time to progression and overall survival were estimated using the Kaplan-Meier method.

Results: Thirty-two glioblastoma cases with positive COVID-19 testing were …

Variability In Performance Of Genetic-Enhanced Dxa-Bmd Prediction Models Across Diverse Ethnic And Geographic Populations: A Risk Prediction Study, Yong Liu, Xiang-He Meng, Chong Wu, Kuan-Jui Su, Anqi Liu, Qing Tian, Lan-Juan Zhao, Chuan Qiu, Zhe Luo, Martha I Gonzalez-Ramirez, Hui Shen, Hong-Mei Xiao, Hong-Wen Deng

Faculty, Staff and Student Publications

BACKGROUND: Osteoporosis is a major global health issue, weakening bones and increasing fracture risk. Dual-energy X-ray absorptiometry (DXA) is the standard for measuring bone mineral density (BMD) and diagnosing osteoporosis, but its costliness and complexity impede widespread screening adoption. Predictive modeling using genetic and clinical data offers a cost-effective alternative for assessing osteoporosis and fracture risk. This study aims to develop BMD prediction models using data from the UK Biobank (UKBB) and test their performance across different ethnic and geographical populations.

METHODS AND FINDINGS: We developed BMD prediction models for the femoral neck (FNK) and lumbar spine (SPN) using both …

Antitumor Activity Of A Novel Lair1 Antagonist In Combination With Anti-Pd1 To Treat Collagen-Rich Solid Tumors, Bertha L Rodriguez, Jiawei Huang, Laura Gibson, Jared J Fradette, Hung-I H Chen, Kikuye Koyano, Czrina Cortez, Betty Li, Carmence Ho, Amir M Ashique, Vicky Y Lin, Suzanne Crawley, Julie M Roda, Peirong Chen, Bin Fan, Jeong Kim, James Sissons, Jonathan Sitrin, Daniel D Kaplan, Don L Gibbons, Lee B Rivera

Faculty, Staff and Student Publications

We recently reported that resistance to PD-1 blockade in a refractory lung cancer-derived model involved increased collagen deposition and the collagen-binding inhibitory receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR1). Thus, we hypothesized that LAIR1 and collagen cooperated to suppress therapeutic response. In this study, we report that LAIR1 is associated with tumor stroma and is highly expressed by intratumoral myeloid cells in both human tumors and mouse models of cancer. Stroma-associated myeloid cells exhibit a suppressive phenotype and correlate with LAIR1 expression in human cancer. NGM438, a novel humanized LAIR1 antagonist mAb, elicits myeloid inflammation and allogeneic T-cell responses by binding …

The T2-Flair Mismatch Sign In Oncologic Neuroradiology: History, Current Use, Emerging Data, And Future Directions, Samir A Dagher, Riley Hideo Lochner, Burak Berksu Ozkara, Donald F Schomer, Max Wintermark, Gregory N Fuller, F Eymen Ucisik

Faculty, Staff and Student Publications

The T2-Fluid-Attenuated Inversion Recovery (T2-FLAIR) mismatch sign is a radiogenomic marker that is easily discernible on preoperative conventional MR imaging. Application of strict criteria (adult population, cerebral hemisphere location, and classic imaging morphology) permits the noninvasive preoperative diagnosis of isocitrate dehydrogenase (IDH)-mutant 1p/19q-non-codeleted diffuse astrocytoma with near-perfect specificity, albeit with variably low sensitivity. This leads to improved preoperative planning and patient counseling. More recent research has shown that the application of less strict criteria compromises the near-perfect specificity of the sign but remains adequate for ruling out IDH-wildtype (glioblastoma) phenotype, which bears a far grimmer prognosis compared to IDH-mutant diffuse …

Effects Of Extreme Starvation On The Fasting-Adapted Western Rattlesnake (Crotalus Oreganus), Brandon R. Kong

Master's Theses

Ambush-hunting snakes have long been of great interest in the biology of fasting and starvation, as they are adapted to withstand well over a year without taking a meal. Well-justified ethical constraints have limited our understanding of their biology at the limits of these abilities. Unfortunate circumstances, in which the California Department of Fish and Wildlife confiscated over 50 Western Rattlesnakes (Crotalus oreganus) from an animal hoarder that had long neglected them, culminated in the euthanized animals ending up in the hands of our lab. Some of these snakes were extremely starved, being only one-half to one-third of …

Effect Of Enzymatic Pretreatment On Biomethane Production From Olive Pomace, Ningjing Zhong

Master's Theses

In 2023, approximately 2.36 million metric tons of olive oil were produced globally. Olive pomace, a byproduct of the flesh and pits left after olive oil extraction, presents environmental challenges when used as landfill due to its high polyphenol and organic contents, or when combusted due to greenhouse gas emissions. Its potential as animal feed is limited, yet it holds promise for methane production via anaerobic digestion (AD), providing a source of renewable energy. However, the highly crystallized polysaccharides in olive pomace, such as cellulose, hemicellulose, and pectin, impede its conversion to methane, and the high polyphenol content inhibits methanogen …

The Educational, Living, And Social Conditions Of Farmworker Families Residing In A California Migrant Housing Center, Anna Santana

Social Justice in Educational Leadership EdD Dissertations

Every year, thousands of agricultural workers and their families migrate across states and countries, playing a vital role in global food production, especially in California, home to the largest population of farmworkers in the U.S. Historically, migrant families lived in inadequate housing, but today the state offers 24 seasonal rental housing centers with approximately 1,883 units across 15 counties. However, this type of subsidized housing requires that families live outside a 50-mile radius from these centers for at least three months during the off-season, often forcing children to change schools multiple times a year, disrupting their education. This study explores …

Medical Image Analysis Based On Graph Machine Learning And Variational Methods, Sina Mohammadi

Computational and Data Sciences (PhD) Dissertations

This study explores advanced methodologies for enhancing brain tumor segmentation, addressing the complexity and diversity of tumor sub-regions in medical imaging. We introduce a novel approach utilizing Graph Neural Networks (GNNs) that incorporate both spectral and spatial insights for segmentation. By leveraging various supervoxel creation methods such as VCCS, SLIC, Watershed, Meanshift, and Felzenszwalb-Huttenlocher, we structured 3D MRI images into a graph format. This format enabled the implementation of Spectral and Spatial GNNs to capture comprehensive local and global tumor characteristics effectively. Our Spectral-Spatial GNN model, integrating the Laplacian matrix, demonstrated significant improvements in segmenting distinct tumor sub-regions of Necrosis, …

Towards The Outbreak Tail, What Is The Public Opinion About Wastewater Surveillance In The United States?, Rochelle H. Holm, Lauren B. Anderson, Heather D. Ness, A. Scott Lajoie, Ted Smith

Faculty and Staff Scholarship

National opinions on a wide variety of public health topics can change over time and have highly contextual nuances. This study is a follow-up to prior inquiries into the knowledge of wastewater-based epidemiology, privacy concerns surrounding sample collection, and the use of data acquired, along with privacy awareness from an online survey conducted in the metropolitan United States during the winter of 2023. Mentions of wastewater-surveillance-related terms in the media remained common. Towards the outbreak tail in 2023, public support for surveillance of toxins (91%), diseases (91%), terrorist threats (87%), illicit drugs (70%), prescription medications (69%), and gun residue (60%) …

Assessing The Reactivity Of Amino Acids To Chlorination Using Capillary Electrophoresis, Pedro De Allende

Electronic Theses, Projects, and Dissertations

Amino acids (AA) are ubiquitous in wastewater systems. One of the most popular wastewater treatments is chlorination which is effective at eradicating bacteria and overall treating the wastewater, but it can also produce disinfection by-products (DBPs). Certain DBPs have been classified as Class B Carcinogens to humans and are therefore highly regulated and monitored. Past studies have shown that natural organic matter (NOM), specifically amino acids, can be precursors to DBPs if chlorinated to the correct dose. This thesis project explored AA chlorination's mechanism(s) to understand further which products arise. In particular, the investigation detailed which steps of the mechanism …

The Cultural Mismatch Between Latinas' Interdependent Self-Concept And The Independent Culture Of Stem, Maria Guadalupe Velasco

Electronic Theses, Projects, and Dissertations

I assessed the role of self-concept fit, as outlined in the SAFE model (Schmader & Sedikides, 2018), in Latina college students’ feelings toward pursuing a STEM course. Research on the underrepresentation of certain social groups in STEM has mainly focused on the role of goal fit. More specifically, researchers have found that portraying STEM environments as affording communal goals promotes goal fit, which is related to positive outcomes like interest, belonging, and favorable ratings for STEM courses, careers, and lab positions (Belanger et al., 2017; Belanger et al., 2020; Diekman et al., 2011). Because Latinas are socialized within an interdependent …

Disparities Surrounding The Availability Of Feminine Hygiene Products In The Workplace, Marlene Ventura

Electronic Theses, Projects, and Dissertations

Menstrual inequality in the workplace continues to exist, affecting financial welfare, mental health, physical health, and access to care. Women have been enduring disparities related to menstruation, including stigma, shame, and period poverty, which are often exacerbated in the workplace. This study aims to explore the experiences of women who do not have access to free feminine hygiene products in the workplace.

The researcher conducted one-to-one interviews in person with employed women (n=9). The questions were semi-structured and based on a survey with nineteen questions addressing areas of menstrual inequality in the workplace. Seven themes were identified: 1) work performance, …

Serotonin 1a Receptor Modulation On Behavioral Flexibility In Btbr And C57bl/6j Mice, Cassandra Cavazos

Electronic Theses, Projects, and Dissertations

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by a subset of symptoms known as restricted repetitive behaviors (RRBs). RRBs are categorized into both lower order and higher order RRBs, where the latter can be described as behavioral inflexibility. The BTBR T+ tf/J (BTBR) mouse strain has been an extensively used animal model that demonstrate the behavioral symptoms of these individuals, including inflexible behavior. Currently, there are few effective treatments for individuals with ASD that express RRBs. Past research has investigated treatments that target serotonin due its historic involvement in ASD. 8-OH-DPAT (8-hydroxy-2-(di-n-propylamine) tetralin) is a research …

Examining Construal Level Priming As A Potentional Intervention For Misinformation Sharing, Xiangyu Cui

Electronic Theses, Projects, and Dissertations

Misinformation has become increasingly difficult to combat in the digital age. The current study tested a model exploring the relationships between self-regulation, habitual social media use, construal level, and propagation of misinformation. Drawing from previous research, I hypothesized that individuals with higher self-regulation would exhibit lower susceptibility to misinformation sharing. I also hypothesized that habitual social media use mediates the relationship between self-regulation and misinformation sharing. In addition, I introduced construal level priming as an experimental intervention, where individuals primed with abstract construal levels may demonstrate more discerning information processing, thereby reducing the likelihood of misinformation sharing. Results from data …

The Effect Of Intermediate Doses Of Roundup® On The Larval Development, Survival, Oviposition And Fitness Of Culex Quinquefasciatus, Abdoulaye Aziz Zerbo

Electronic Theses, Projects, and Dissertations

The southern house mosquito, Culex quinquefasciatus, is a vector to many pathogens in Southern California, including West Nile Virus and St. Louis Encephalitis Virus. Immature stages of mosquitoes may be exposed to Roundup^®, a frequently used herbicide worldwide, due to surface runoffs or overspraying and subsequent drifting. Previous studies have shown some negative impacts of sublethal doses of Roundup^® during the developmental stage of Culex quinquefasciatus, such as physiologic changes and prolonged larval stage or the high mortality of larvae due to exposure to the high doses of glyphosate. This study investigated the effect of …

Corn Leaf Disease Prediction Using Deep Learning, Meghana Varayuri

Electronic Theses, Projects, and Dissertations

Corn is a widely cultivated agricultural product, serving as a cornerstone in food production and industrial applications such as biofuels, playing a crucial role in the global economy. This study explores the application of deep transfer learning to accurately classify major corn diseases from leaf images, aiming to enhance disease management strategies for improved agricultural productivity and sustainability. The customized Dense net 201 model achieved 95% prediction accuracy on an untrained dataset. Data augmentation improved the model’s accuracy from 91% to 95%. This supervised learning approach enhances the model’s performance by increasing the diversity, leading to better generalization and accuracy. …

Understanding The Dynamics Of Chatbot Design, Transparency, And Ethical Implications In Customer–Brand Relationship In Hospitality And Tourism Industry, Shakera Parveen

Electronic Theses, Projects, and Dissertations

This culminating experience project investigated the impact of chatbot interactions on customer perceptions, ethical considerations, and transparency within the hospitality and tourism industry. The research questions are: Q1: how do the specific visual and verbal aspects contribute to shaping customer perceptions within the context of chatbot marketing efforts? Q2: what steps can companies take to address and mitigate ethical concerns surrounding interactions with chatbots? Q3: To what extent does the level of transparency and explainability in chatbot interactions influence customer trust and satisfaction? The findings are: Q1: the study revealed that visual and verbal aspects of chatbot design significantly shape …

Emotional Eating In Adolescents With Obesity: Case Series, Paula Dayan

Electronic Theses, Projects, and Dissertations

Childhood obesity remains a significant public health concern, with substantial implications for physical and mental well-being. This thesis aims to explore the intricate relationship between emotional eating and obesity among adolescents, with a focus on identifying emotional triggers and assessing their psychological impact. Utilizing a cross-sectional study design at a university in southern California, data were collected from two adolescents aged 13-18 years. Through surveys and body composition measurements, participants' emotional barriers to weight loss and readiness for change were assessed. The findings underscore the presence of varying degrees of emotional hurdles among adolescents with obesity, including depression, frustration, and …

Advancing Telehealth Through Artificial Intelligence: Incorporating Emotional Intelligence And Addressing Cybersecurity Challenges, Mahima Rajendra Pulgaonkar

Electronic Theses, Projects, and Dissertations

This culminating experience project explores the integration of Emotional Artificial Intelligence (Emotional AI) into telehealth systems, addressing the dual challenges of enhancing patient care and mitigating cybersecurity risks. The research questions are: (Q1) How can Emotionally Intelligent AI improve telehealth systems' ability to recognize and respond to mental health symptoms? and (Q2) What are the specific cybersecurity challenges associated with AI in telehealth and how can they be mitigated? The findings for each question are: Q1: Emotionally Intelligent AI can significantly enhance telehealth by providing personalized, empathetic interactions that improve patient engagement, adherence to treatment plans, and early detection of …

Food Waste Study At A School District In California, Monica Ibarra

Electronic Theses, Projects, and Dissertations

This study is aimed at evaluating food leftovers and wastes among elementary school students by comparing their food preferences for different ethnic cuisines, developing strategies to reduce food waste, and an assessment of quality assurance of food served. Data were collected from a cafeteria at an elementary school located in California. The total number of students served each day at this elementary school was 475. Data were provided by the cafeteria staff after the lunch was served. It was observed that students preferred Chinese food (specifically, Orange Chicken) over Mexican (Beef Chalupas) and American (Turkey with Gravy) where100% of the …

Effects Of A Proprietary Kelp Blend Product On Enteric Methane Production And Tissue Residues In Cattle, Alexander Altman, Eric Vanzant, Sydney Davis, David Harmon, Kyle R. Mcleod

Animal and Food Sciences Faculty Publications

Three experiments were performed investigating bovine enteric methane (CH₄) production inhibition using a proprietary kelp blend product (PKBP) containing a halogenated methane analog (i.e., bromoform). Calves were fed a corn-silage basal diet top-dressed with the assigned treatment, with rations provided at 1.5 × NE_m in Experiments 1 and 2 (n = 12 and 6 steers, respectively) and ad libitum in Experiment 3 (n = 9 steers). In Experiment 1, we evaluated bromoform’s potency in decreasing CH₄. Dry matter intake (DMI) was not affected by treatment (p ≥ 0.11; 0 vs. 52.5 ± 10.5 ppm bromoform), …

Changes In Blood Lactate And High Intensity Exercise Endurance During A Strength - Endurance Accumulation Training Using Accentuated Eccentric Loading, Nicholas Goode

Electronic Theses and Dissertations

The purpose of this study was to investigate the effects of accentuated eccentric load (AEL) resistance training and changes in work capacity, high-intensity exercise endurance (HIEE) and lactate metabolism. Seventeen recreationally trained subjects (11 males and 6 females) (mean ± SD: age = 23.2 ± 4.2 yrs, BM = 81.3 ± 22.2 kg, height = 172.1 ± 10 cm, male relative back squat (BS) [MD1] strength (1RM*BM^-1) = 1.64 ± 0.32 kg*kg^-1, female relative BS strength = 1.39 ± 0.32 kg*kg^-1) participated in the study. Subjects completed a week of familiarization to participate in …

Piecewise Fractional Derivatives And Wavelets In Epidemic Modeling, Mutaz Mohammad, Mohyeedden Sweidan, Alexander Trounev

All Works

In this paper, we propose a novel methodology for studying the dynamics of epidemic spread, focusing on the utilization of fundamental mathematical concepts related to piecewise differential and integral operators. These mathematical tools play a crucial role in the process of modeling epidemic phenomena, enabling us to investigate the behavior of infectious diseases within defined time intervals. Our primary objective is to enhance our understanding of epidemic dynamics and the underlying influencing factors. We introduce the Susceptible–Infectious–Recovered (SIR) model as the foundational framework, which is formulated as a system of differential equations. Our approach involves discretizing time and employing interpolation …

The Lived Experiences Of Transition-Age Youth With Usher Syndrome Preparing For Postsecondary Education: A Retrospective Study, Tara Mae Brown-Ogilvie

Dissertations

Youth with Usher syndrome (USH) can experience unique challenges in postsecondary preparation. Currently, there is a paucity of research addressing the postsecondary preparation experiences of youth with USH. The purpose of this study was to learn from college students with USH about their lived experiences of preparing for postsecondary education; specifically, exploring K-12 educational supports, transition planning, and support systems that helped youth with USH prepare for postsecondary education. Due to the unique nature of this microcosm of deafblindness, qualitative and phenomenological methods were best suited for this study to garner first-hand accounts of those who have experienced this phenomenon …

Implicit Bias Toward Students With Attention-Deficit/Hyperactivity Disorder And The Influential Role Of Teacher Self-Efficacy, Laurie Claire Landrieu

Dissertations

The current study observed the presence of implicit bias toward students with Attention-Deficit/Hyperactivity Disorder (ADHD) in the classroom and the influential role of teacher self-efficacy. Teachers report a lack of readiness to work with students with diverse learning needs. Students with alternative learning needs, such as those with ADHD, report less social competency with adults and peers, and lower self-concept. The purpose of the study is to provide further information about the implicit biases held toward students with ADHD within the classroom and the influential role of teacher self-efficacy. Forty general education teachers were recruited. A paired samples t-test was …

Facilitating Language Development In Late-Talking Toddlers: A Study Of Caregiver Training And Intervention Effectiveness, Kelly Meadows

Dissertations

The prevalence of late language emergence (LLE) in young children is high, comprising 10 to 20% of toddlers. Late language emergence refers to children who do not use at least 50 single words and 2-word phrases at the age of two. Current best practices for the under-three population with or at risk of having disabilities include the use of family-centered services in early intervention. One method of EI for LLE is caregiver-implemented interventions, where the caregiver learns techniques or strategies to help support their child’s expressive language development. This service delivery model prioritizes building the family’s capacity to support their …

Understanding The Acculturation Experiences Of Post-9/11 Student Veterans In The Higher Education Culture Of Civilian Postsecondary Educational Institutions, Jansen Sheridan Legreid

Dissertations

The purpose of this study was to describe the essence of the acculturation experiences of post-9/11 student veterans as they navigated within the dominant higher education culture of civilian postsecondary educational institutions (PEIs). Specifically, this study aimed to conceptualize the acculturation experiences of post-9/11 student veterans by simultaneously identifying the components of their military cultural identity that they decided to maintain or abandon in PEI settings as well as which components of the dominant higher education culture that they decided to adopt or reject. This study answered the following research questions: Q1 What are the acculturation experiences of post-9/11 student …

Voices Of Change: Exploring The Narratives Of Physical Education Stakeholders’ Policy Work In Colorado, Lisa Paulson

Dissertations

Quality physical education, pivotal for the development of physical, social, and emotional skills for an active and healthy lifestyle (Society of Health and Physical Educators [SHAPE] America, 2014; United Nations Educational, Scientific, and Cultural Organization [UNESCO], 2021), has been globally marginalized, necessitating a heightened focus on policy advocacy engagement (Hardman, 2013; van der Mars, 2021). Policies touch nearly all aspects of physical education (UNESCO, 2014), and a significant barrier is the ‘policy illiteracy’ that contributes to the field’s neglect (van der Mars et al., 2021). Many educators receive little to no policy education, often not identifying as policy actors (Lorusso …

Undergraduate Nurse Educators’ Conceptualization And Utilization Of Deliberate Practice In Psychomotor Skills Education, Sarah Bundren Tappendorf

Dissertations

Nurses are responsible for providing safe patient care. When nurses lack skill competence, patient harm can occur. Therefore, providing skill competency education in pre-licensure nursing programs is key to providing safe patient care. Deliberate practice (DP) has been shown to be an effective teaching strategy for psychomotor skills acquisition and retention. Deliberate practice is the repetitive focused practice of skills facilitated by expert feedback with the goal to obtain mastery. The purpose of this descriptive, cross-sectional, quantitative study was to determine the proportion of undergraduate nurse educators who knew or did not know about DP, what undergraduate nurse educators who …