Digital Commons Network^™

Benefits And Challenges Of Geographic Information Systems (Gis) For Data-Driven Outreach In Black Communities Experiencing Overdose Disparities: Results Of A Stakeholder Focus Group, Devin E Banks, Maria Paschke, Rashmi Ghonasgi, Vetta L Sanders Thompson

2020-Current year OA Pubs

BACKGROUND: Black individuals in the U.S. face increasing racial disparities in drug overdose related to social determinants of health, including place-based features. Mobile outreach efforts work to mitigate social determinants by servicing geographic areas with low drug treatment and overdose prevention access but are often limited by convenience-based targets. Geographic information systems (GIS) are often used to characterize and visualize the overdose crisis and could be translated to community to guide mobile outreach services. The current study examines the initial acceptability and appropriateness of GIS to facilitate data-driven outreach for reducing overdose inequities facing Black individuals.

METHODS: We convened a …

Brca1 Secondary Splice-Site Mutations Drive Exon-Skipping And Parp Inhibitor Resistance, Ksenija Nesic, John J Krais, Et Al.

2020-Current year OA Pubs

PARP inhibitor (PARPi) therapy has transformed outcomes for patients with homologous recombination DNA repair (HRR) deficient ovarian cancers, for example those with BRCA1 or BRCA2 gene defects. Unfortunately, PARPi resistance is common. Multiple resistance mechanisms have been described, including secondary mutations that restore the HR gene reading frame. BRCA1 splice isoforms △11 and △11q can contribute to PARPi resistance by splicing out the mutation-containing exon, producing truncated, partially functional proteins. However, the clinical impacts and underlying drivers of BRCA1 exon skipping are not fully understood.We analyzed nine ovarian and breast cancer patient derived xenografts (PDX) with BRCA1 exon 11 frameshift …

Cardioprotective Efficacy Of Sevoflurane In Patients With Rheumatic Heart Disease Undergoing Heart Valve Surgery Under Cardiopulmonary Bypass, Vu Thanh Lam, Nguyen Quoc Kinh, Nguyen Minh Ly

Journal of the Saudi Heart Association

Objectives

In this study, we investigated whether cardioprotective properties of sevoflurane were expressed in patients with rheumatic heart disease undergoing heart valve surgery under cardiopulmonary bypass (CPB).

Methods

Fifty patients with rheumatic heart disease undergoing heart valve surgery under CPB were randomly assigned to receive total anesthesia with sevoflurane or propofol during surgery. Except for this, anesthetic and surgical management was the same in all patients. The primary outcomes were postoperative high-sensitive cardiac troponin T (hs-cTnT) and creatine kinase-myocardial band (CK-MB) release. The secondary outcomes were hemodynamic events and short-term clinical outcomes (within 30 days after surgery).

Results

The plasma …

The Py4 Mission: A Low-Cost Demonstration Of Cubesat Formation-Flying Technologies, Max Holliday, Rachel Ticknor, Jan Stupl, Roger Hunter, Paulo Fisch, Ibrahima Sory Sow, Jacob Willis, Zachary Manchester

Small Satellite Conference

The PY4 mission aims to enable autonomous swarms of small spacecraft by both reducing the manufacturing cost and integration effort required for individual spacecraft, and by advancing guidance, navigation, and control algorithms that increase autonomy and reduce or eliminate the need for expensive sensor, actuator, and propulsion hardware. PY4 consists of four 1.5U CubeSats, and builds on the PyCubed open-source avionics platform and the previous V-R3x mission. To date, PY4 has successfully demonstrated high-data-rate mesh networking, precise inter-satellite ranging, range-based relative orbit determination, and magnetorquer-only sun pointing. A drag-based formation-flying experiment is also planned for an extended mission.

Ninjasat: Initial Operation Results Of The First Japanese 6u Cubesat For Bright X-Ray Sources, Tomoshi Takeda, Naoyuki Ota, Sota Watanabe, Amira Aoyama, Satoko Iwata, Takuya Takahashi, Kaede Yamasaki, Yuanhui Zhou, Keisuke Uchiyama, Yuto Yoshida, Syoki Hayashi, Arata Jujo, Toru Tamagawa, Takao Kitaguchi, Yo Kato, Tatehiro Mihara, Kentaro Taniguchi, Teruaki Enoto, Wataru Iwakiri, Masaki Numazawa, Hiroki Sato, Chin-Ping Hu, Hiromitsu Takahashi, Hirokazu Odaka, Tsubasa Tamba

Small Satellite Conference

We report the initial operation results of the first Japanese 6U CubeSat X-ray observatory NinjaSat, which was launched into a sun-synchronous orbit at an altitude of 530 km on November 11, 2023, by the SpaceX Transporter-9 mission. NinjaSat is designed to observe bright X-ray sources in the sky, such as black holes and neutron stars, which are often difficult to observe with modern large X-ray satellites due to instrument limitations. After the payload verification, NinjaSat observed the Crab Nebula on February 9 and correctly detected the 33.8 ms pulsation from the neutron star. With this observation, NinjaSat met the minimum …

Spirit Mission: In-Orbit Results And Technology Demonstrations, Michele Trenti, Miguel Ortiz Del Castillo, Robert Mearns, Jack Mcrobbie, Clint Therakam, Airlie Chapman, Andrew Woods, Jonathan Morgan, Simon Barraclough, Ivan Rodriguez Mallo, Giulia Baroni, Fabrizio Fiore, Yuri Evangelista, Riccardo Campana, Alejandro Guzman, Paul Hedderman

Small Satellite Conference

The Space Industry Responsive Intelligent Thermal (SpIRIT) 6U CubeSat is a mission led by The University of Melbourne in cooperation with the Italian Space Agency. SpIRIT received support from the Australian Space Agency and includes contributions from Australian space industry and international research organizations. Developed over the last four years and launched in a 510 km Polar Sun Synchronous Orbit in December 2023, SpIRIT carries multiple subsystems for scientific and technology demonstration. The main scientific payload is the HERMES instrument, a gamma and X-ray detector for detection of high-energy astrophysics transients (primarily Gamma Ray Bursts), and for studies of their …

The Tragic Life And Misconstrued Work Of Jules Verne, Gary Lynch

Mythcon

Gary Lynch presents on Jules Verne.

Before And After: Editing A Collection Through The Pandemic, Cami Agan

Mythcon

At Mythcon in San Diego (2019, the “before time”), the Stewards approved my proposal for the collection of essays entitled Cities and Strongholds of Middle-earth; Essays on the Habitations of Tolkien’s Legendarium from Mythopoeic Press. I will discuss the process of soliciting contributors, compiling, cajoling, editing, developing the introduction, proofing the volume, working with MythPress editors, as well as discuss how the COVID-19 pandemic affected/ affects the process of publication, and offer a general overview of the volume itself, which [Varda willing!] will be available for order at Mythcon53.

From Development Through Re-Entry: Ctim Operational Lessons Learned And Successes, Sierra Flynn, Gabe Bershenyi, Brian Boyle, Dave Harber, Beth Cervelli, Scott Gennari, Adalyn Fyhrie, Adrienne Pickerill, Jacob Sprunk, Karen Bryant, Cody Folgmann

Small Satellite Conference

The University of Colorado’s Laboratory for Atmospheric and Space Physics’ (CU-LASP) Compact Total Irradiance Monitor (CTIM) SmallSat mission was a 6U CubeSat designed full-cycle and in-house between 2018-2022 and flew for 1.5 years after launch until re-entry, overshooting the 1-year mission lifetime goal. CTIM's primary mission was to measure the total irradiance of the Sun, with ancillary measurements of the night-side Earth IR radiance, while demonstrating new technological capabilities of silicon-substrate room temperature vertically aligned carbon nanotube (VACNT) bolometers. The instrument was based on the Total Irradiance Monitor design that flew on SORCE (2003), TCTE (2013), and TSIS (2017). CTIM …

From Ground To Orbit: Enhancing Satellite Autonomy With Ai-Powered Anomaly Detection, James Murphy, Fangyijie Wang, Muhammad Deedahwar Mazhar Qureshi, Brian Mac Namee

Small Satellite Conference

Recent advances in space technology have prompted a surge in the deployment of small satellite constellations by companies such as Starlink and OneWeb. Now numbering in the thousands, these constellations have significantly increased the burden on satellite operators who must monitor and manage them to ensure their safe and reliable functioning. In response to this heightened operational demand, autonomous small satellite operations have become a focal point for investment, innovation and exploration. The latest hardware breakthroughs in Edge AI have paved the way for applying artificial intelligence (AI) techniques directly on board these small satellite systems, heralding a new era …

Dorre: Autonomous Event Response Using An 8-Spacecraft Constellation, Michael Swartwout, Keith J. Bennett

Small Satellite Conference

Autonomy - the ability of system to retask itself in response to unexpected/unmodeled events - is an enabling technology for space missions. However, autonomy carries risk: what if the system makes unexpected or dangerous decisions? How can human operators trust that the system will not exceed certain bounds of behavior? Are we sure that an autonomous vehicle will outperform a human-directed system?

To address these questions, the Space Systems Research Laboratory (SSRL) of Saint Louis University is developing the Distributed Observation Reasoning and Reaction Experiment (DORRE). DORRE consists of 8 spacecraft operating together in low-Earth orbit to conduct a series …

Wolfsat-1: A 1u Cubesat To Monitor Enzyme Activity Of Ideonella Sakaiensis In The Microgravity Environment, Kevin Simmons, Jasmin Consales, Alexander Castronovo, Colin Quinn, Daniel Portal Levy, Dylan Kiesling, Paul Kiesling

Small Satellite Conference

The Problem: Plastic Pollution • 420 million tons of plastic waste/year. • Microplastics pervade in the air, water, and soil of Earth and have even been found in human blood. • We need to recycle single use plastics in an energy efficient manner.

Arcticsat: A Cubesat For Canada’S North, With Canada’S North, Andrew Bowman, David Kattegatsiak, Spencer Ryznar, Layne Ransom, Shakiba Mir Ahmadi, Aref Asgari, Riley Sweeney, Ricky Gill, Vishnu Nadan, Bashar Esmail, Fatiah Balogun, Dustin Isleifson, Kiledar Singh Tomar, John Yackel, Philip Ferguson

Small Satellite Conference

Canada’s northern Inuit and Indigenous communities are experiencing climate change four times faster than the rest of the planet, impacting their traditional means of travel, hunting, and fishing. As temperatures rise, the sea ice forms later and melts earlier, allowing less time to perform these activities safely. While current satellite radiometry data can provide insight into the safety of the ice, Inuit communities require more timely and open access to this data. ArcticSat is a 3U CubeSat being co-developed with the Hamlet of Chesterfield Inlet, Nunavut, Canada, made to accomplish these goals. Community co-development ensures that community members lead the …

Pulse Pocketqube: Cosmic Radiation Analysis Of The Leo Environment During A Solar Event, Faith Tng, Vasantha Kanesh Muruganantham, Palaniappan Subramanian, Cem Avsar

Small Satellite Conference

Space weather events can cause harmful effects to spacecraft and communications in Low Earth Orbit, where the cosmic radiation environment during such an event is understudied. Real-time data that characterizes this environment in detail with respect to spatial and temporal characteristics could help us better understand particle composition and interactions in LEO during a solar event, as well as enhance existing predictive models for space mission planning. Current approaches have limited information on particle composition with respect to dose and energy rates, and are hindered by high costs in deploying large space weather monitoring constellations. This proposed satellite mission, PULSE, …

Adrenal Suppression From Vamorolone And Prednisone In Duchenne Muscular Dystrophy: Results From The Phase 2b Clinical Trial, Alexandra Ahmet, Rebecca Tobin, Utkarsh J. Dang, Raoul Rooman, Michela Guglieri, Paula R. Clemens, Eric P. Hoffman, Leanne M. Ward

Pharmacy Faculty Scholarship

Context: Vamorolone, a novel “dissociative” steroid, demonstrated similar efficacy in muscle function relative to prednisone 0.75 mg/kg/day but improved linear growth and bone turnover markers in a randomized trial of pediatric Duchenne muscular dystrophy (DMD). Objectives: To determine the frequency of adrenal suppression (AS) induced by vamorolone and prednisone in pediatric DMD and to assess cortisol thresholds using a monoclonal antibody immunoassay. Methods: Post hoc analysis of cortisol levels was performed on data from a randomized, double-blind, placebo- and prednisone-controlled 24- week trial of vamorolone with a 24-week crossover extension. Morning and ACTH-stimulated cortisol levels were measured using the Elecsys …

Developing A Summer Enrichment Program For School-Aged Children: The Role Of Occupational Therapy In Summer Experiences, Morgann Lonczak

Department of Occupational Therapy Entry-Level Capstone Projects

Participation in summertime experience for youth have become increasingly popular in most recent years. With the growth in summer experiences including summer camp participation, there is a need to determine the role of occupational therapy in this emerging practice area to best serve the community. A 16-week capstone experience was completed under the supervision of Great Strides Rehabilitation occupational therapy staff. The capstone project aimed to fill a gap in summertime experiences by designing and implementing an occupational therapy led enrichment program to achieve the best outcomes for children and youth. A six-week enrichment program was successfully developed, and two-weeks …

Occupational Therapy's Role For Individuals With Long-Term Neurological Conditions, Courtney Ahle

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

The Role Of Occupational Therapy In Long Covid Rehabilitation, Lisa H. Hamilton

Department of Occupational Therapy Entry-Level Capstone Projects

This capstone project explores the integration of Occupational Therapy (OT) into primary care settings, focusing on chronic conditions such as long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). These conditions are often misunderstood by both healthcare providers and the broader community due to their complex and multifaceted symptoms, which necessitate specialized care. The project aimed to create resources and educational materials tailored to the needs of patients and rehabilitation professionals, to enhance the management of these challenging conditions. Additionally, the project placed a strong emphasis on advocacy for individuals with "invisible disabilities," aiming to raise awareness and improve accessibility to …

Remote Work Ergonomics: A Doctoral Capstone Experience, Kaynath Bhamani

Department of Occupational Therapy Entry-Level Capstone Projects

As remote work becomes increasingly prevalent, ensuring effective ergonomic practices in home-based work environments has emerged as a critical concern. This paper attempts to explore challenges that are associated with remote work and proposes solutions for creating healthier home office environments.

Increasing Parent Participation In Nicu Care And Preparation For Discharge, Biancah A. Derival

Department of Occupational Therapy Entry-Level Capstone Projects

My capstone project aimed to understand the current evidence that examines the benefits of NICU parental participation to increase preparedness for discharge and provide educational resources to parents and professionals. The first half of my project entailed a revision of hospital provided material to create a weekly developmental timeline that parents can understand. During the second half, educational materials were collected to address parental concerns including early intervention resources, sensory activities/strategies, and age-appropriate toys, safe sleep, and tummy time. Families can incorporate this information in the NICU and the home environment. The resources were revised into physical handouts to take …

Understanding Occupational Therapy’S Role In Injury Prevention For Pickleball Players And Communities, Kelly Lambert

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

An Anxiety And Coping Mechanism Educational Program For Children And Adolescents, Amanda Garrett

Department of Occupational Therapy Entry-Level Capstone Projects

The following capstone project encompassed creating and implementing an educational program focusing on anxiety and coping mechanisms for adolescents 12-15 years of age at the YMCA in Largo, Florida. The academic program focuses on six different types of anxiety, which are generalized anxiety, social anxiety, test anxiety, feelings of panic, feelings of stress, and health anxiety, all in a PowerPoint format. Each of these topics also included a coping mechanism that the teens completed after learning about each different type of anxiety. These coping mechanisms included journaling, creating a stress ball, participating in a yoga class, completing a scavenger hunt …

Development Of An Intensive Outpatient Program (Iop) For Adolescents Of American Military Members Deployed Overseas To Support Mental Health, Aaron N. Brion, Tyler J. Russo

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Trauma Informed Care In Hippotherapy, Erin M. Deren

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Advocating For The Role Of Occupational Therapy In A Community-Based Setting Through The Use Of Journaling For Individuals With Chronic Mental Illness, Taylor Muzik-Eversdijk

Department of Occupational Therapy Entry-Level Capstone Projects

Individuals who battle severe mental illness (SMI) experience a range of deficits that affect various aspects of daily life, including activities of daily living (ADLs), instrumental activities of daily living (IADLs), social participation, sleep and rest, education, work, leisure, and play. Research suggests that journaling can help individuals with SMI express their emotions and provide a healthy outlet for coping with symptoms. This doctoral capstone project aimed to identify the unique needs of individuals with SMI and explore how journaling and other occupational therapy (OT) interventions could expand the scope of practice within Boley Centers' assertive community treatment (ACT) teams …

Enhancing Occupational Therapy Doctoral Capstone Planning: Integrating 2023 Standards Into Curriculum, Samantha Edwards

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Occupational Therapy With Refugees And Asylum Seekers, Hana Listes

Department of Occupational Therapy Entry-Level Capstone Projects

The capstone project aimed to define the role of occupational therapy in the reintegration of refugee families in Jacksonville, Florida, in collaboration with Muslim American Social Services. The project focused on utilizing occupational therapy to identify and address barriers faced by refugees during their resettlement process. Following assessment of barriers, culturally sensitive intervention strategies were implemented to improve independence and participation in meaningful daily activities. Interventions focused on the development of targeted programs that addressed challenges such as language barriers, access to resources, and cultural adjustment. Implications of the project aim to advocate for occupational therapy as a stakeholder in …

Increasing Operating Room Efficiency Through Decreased Turnover Times, R. Keith Wolfskill

Student Scholarly Projects

The Operating Room (OR) is the financial engine of the modern hospital or surgical center. Over 40% of the hospital's cost is invested in the OR, but the facility recoups a monetary return of around 60-70%. Turnover time is a crucial factor in reducing costs. Uncontrolled, it can inflate operating costs, but when managed effectively, it can boost surgeon, patient, and staff satisfaction, enhance patient safety, and significantly reduce operational costs. The literature underscores the importance of reducing the time between operating room turnovers to improve OR efficiency. A key strategy that research consistently shows to be effective is the …

Exploring The Interaction Between Klebsiella Pneumoniae And Clostridioides Difficile At The Mucosal Interface, Taylor D. Ticer

MUSC Theses and Dissertations

The gut microbiota plays a major role in human diseases. The impact of these microbes on human health comes not only from individual microbes but also from their interactions with each other. A prime example of this is Clostridioides difficile, an intestinal pathobiont that causes severe gastrointestinal illness. C. difficile works cooperatively with other gut bacteria, including Klebsiella pneumoniae. We hypothesized that K. pneumoniae would work synergistically with C. difficile and promote its pathogenesis. We screened over 40 K. pneumoniae strains to assess their interaction with the intestinal mucus layer, a key colonization site for C. difficile. …

Enhancing Patient Throughput From Emergency Department To Inpatient Unit With Electronic Handoff Implementation, George Hanania

Master's Projects and Capstones

Background: This evidence-based improvement project aimed to address communication issues during information exchange among healthcare professionals and the operational impacts of ineffective nurse-to-nurse reports among the emergency department (ED) to the inpatient units at a northern California hospital-based system hospital in San Leandro. The impacts of miscommunication and ineffective ways of giving nurse-to-nurse reports over the phone can result in delays in treatment and diagnosis, leading to ED overcrowding and decreased throughput.

Problem: Communication issues during information exchange, specifically operational impacts of ineffective nurse-to-nurse report/handoff between the ED and inpatient units.

Interventions: This project aimed to implement an electronic handoff …