Digital Commons Network^™

Closing The Gap: Using The Echo Model To Improve Access To Hereditary Colorectal Cancer Risk Assessment And Genetic Counseling In The Rural Setting, Stephanie Sharp, Linda Steinmark, Emily Edelman, Kate Reed, Kelly Barnes, Susan Miesfeldt

MaineHealth Maine Medical Center

Background There is underutilization of colorectal (CRC)-related cancer genetic counseling services nationally, especially in underserved regions. Novel models of cancer genetic care in rural states like Maine are needed to narrow the practice gap, reflected in an improvement in the percentage of individuals meeting genetic testing guidelines referred for cancer genetic counseling. Goal To lower the CRC cancer genetic counseling practice gap within a Maine-based integrated health system by build ing clinician capacity to identify hereditary CRC risk and facilitate provision of genetic counseling and testing services via the Project ECHO® hub-and-spoke telementoring model. Intervention MaineHealth (MH) and The Jackson …

Immediate Vs Delayed Feedback In A Progressive Musculoskeletal E-Module Case For Clinical Reasoning Development, Megan Frazee, Krista Gipson, Elizabeth Lyden, Stephanie Langel

Innovations in Health Sciences Education Journal

Introduction: Clinical reasoning (CR) skills are essential when preparing healthcare students to transition to clinical practice. The purpose of this study was to evaluate the effects of feedback timing within a case-based learning (CBL) e-module. The secondary aim was to examine the longitudinal impact on student performance within a standardized patient (SP) simulation and their overall course grade at the end of the semester.

Review of Literature: Feedback is a powerful teaching method to improve student learning. However, there are highly conflicting results regarding the best frequency and timing of feedback. This may be influenced by the level of the …

Unmc Quick Checks: An “Opt-Out” Model For Health Profession Student Appointments With Mental Health Counseling Services, Hannah K. Tandon Md, Taylor J. Kratochvil Md, Ms, Katherine L. Keiser Ms, Limhp, Nicole J. Kent Bs, Kaitlyn E. Schultis Bs, Jeffrey W. Knapp Msw, Jeffrey P. Gold

Innovations in Health Sciences Education Journal

Background: Health professions trainees experience high rates of anxiety and depression but are often reluctant to seek help. Institutional outreach during pre-clinical training may identify vulnerable students, improve resource awareness, and destigmatize psychological counseling. The University of Nebraska Medical Center (UNMC) Quick Check program is a novel opt-out program connecting health professions students to mental health counselors.

Objective: The purpose of this study was to evaluate student perceptions and utilization of mental health resources after participation in the UNMC Quick Check program.

Methods: For this limited pilot study, second-year pharmacy students were assigned to UNMC Quick Check appointments with UNMC …

Paradox Of Trust: Examining The Intermediaries That Shape Trust In Va Among The Veteran Population, Jonathan Mills

Walden Dissertations and Doctoral Studies

The Department of Veterans Affairs (VA) has faced significant challenges in maintaining the trust of the veterans it aims to serve—especially those veterans most at risk for adverse outcomes. While veterans currently enrolled in VA care report high trust in the quality of their care, nonenrolled veterans report much lower levels of trust, preventing them from seeking the care they need. This study explored the complex dynamics and drivers of low trust among veterans who are not enrolled in VA healthcare, versus higher reported trust among veterans who are. The research leveraged organizational reputation theory and the macro cognitive perspective …

Nfl Franchise Departures And Nearby Home Prices, Brad R. Humphreys, Geoffrey Propheter

Economics Faculty Working Papers Series

Research shows that US professional sports facilities positively impact nearby house prices. New facilities typically have existing teams, complicating a separate assessment of the impact of teams and facilities. Existing research analyzed departures of pro basketball teams, but arenas host many non-sporting events. These results may not generalize. We exploit the relocation of two professional football teams to investigate the impact of team departures on home sales. Difference-in-differences and repeat sales model results indicate proximity to one team represented an amenity while proximity to the other did not. Differences in urban form likely explains this heterogeneity.

Impacts Of Diets And Weight On Cognitive Decline Diseases Among The Middle-Aged Populations In Louisiana, Danielle Beamon

Walden Dissertations and Doctoral Studies

Cognitive decline is a public health concern since people are living longer, but little is known regarding how to prevent the progression of this condition; furthermore, current treatment options are not always effective after diagnosis. Previous research indicated obesity was associated with diminishing cognitive health, but most studies were conducted on individuals over the age of 65. The purpose of the study was to determine if there is a statistical correlation between cognitive decline and body mass index (BMI) among those between the ages of 40 and 64 years. Data from the 2015-2020 Behavioral Risk Factor Surveillance System Alzheimer’s Disease …

The Lived Experiences Of Spouses Of First Responders Incident To The October 1, 2017, Mass Shooting In Las Vegas, Nevada, Kareen Larae Benson

Walden Dissertations and Doctoral Studies

Research concerning first responders delves into understanding their job environment, their exposure to work hazards, and their reactions to traumatic events. However, few scholars have considered the impact of first responder work on their spouses/partners. Consequently, the purpose of this phenomenological qualitative study was to learn about the lived experiences of the spouses/partners of the first responders who responded within the first 12 hours to the mass shooting in Las Vegas, Nevada, during the Route 91 Harvest Festival, on October 1, 2017. Six participants (from law enforcement, firefighters, and emergency services personnel) who were current or former spouses/partners of first …

Exploring The Feasibility Of Bidirectional Control Of Beta Oscillatory Power In Healthy Controls As A Potential Intervention For Parkinson’S Disease Movement Impairment, Krithika Anil, Giorgio Ganis, Jennifer Freeman, Jonathan Marsden, Stephen Hall

School of Health Professions

Neurofeedback (NF) is a promising intervention for improvements in motor performance in Parkinson’s disease. This NF pilot study in healthy participants aimed to achieve the following: (1) determine participants’ ability to bi-directionally modulate sensorimotor beta power and (2) determine the effect of NF on movement performance. A real-time EEG-NF protocol was used to train participants to increase and decrease their individual motor cortex beta power amplitude, using a within-subject double-blind sham-controlled approach. Movement was assessed using a Go/No-go task. Participants completed the NASA Task Load Index and provided verbal feedback of the NF task difficulty. All 17 participants (median age …

Physical, Cognitive, Emotional, And Social Health Outcomes Of Parents In The First Six Months After Childhood Critical Illness: A Prospective Single Centre Study: A Prospective Single Centre Study, Pei Fen Poh, Jan Hau Lee, Rehena Sultana, Joseph C. Manning, Matthew C. Carey, Jos M. Latour

School of Nursing and Midwifery

Childhood critical illness can have long-term effects on families, but the extent and trajectory of recovery for parents are unknown. Using prospective longitudinal design, we describe the health outcomes of parents and their trajectory six months after paediatric intensive care unit (PICU) discharge. Parents reported health outcomes at PICU discharge (baseline), and 1-, 3-, and 6-months post-discharge. We used the Pediatric Quality-of-Life Family Impact Module, Patient Health Questionnaire-4, and post-traumatic stress disorder (PTSD) Checklist for DSM-5. The group-based trajectory model was used to identify recovery patterns. We included 128 parents of children aged 1 month to 18 years, admitted to …

Accumulation Of Environmental Radioactivity On The Surface Of A High Arctic Ice Cap (Flade Isblink, Ne Greenland), Dylan B. Beard, Giovanni Baccolo, Caroline C. Clason, Geoffrey E. Millward, Edyta Łokas, Elena Di Stefano, Sally Rangecroft, Dariusz Sala, Przemysław Wachniew, William H. Blake

School of Geography, Earth and Environmental Sciences

Under climatic warming, glaciers are becoming a secondary source of atmospheric contaminants originally released into the environment decades ago. This phenomenon has been well-documented for glaciers near emission sources. However, less is known about polar ice sheets and ice caps. Radionuclides are one of the contaminants that can be remobilised through ice melting and accumulate in cryoconite material on the surface of glaciers. To understand the cycling of radionuclides in polar glacial contexts, we evaluate the radioactivity of cryoconite samples from Flade Isblink, a High Arctic ice cap in northeast Greenland. The measured radioactivity is among the highest reported across …

A ‘Nuclear Bomb’ Or Just ‘A Joke’? Groundwater Models May Help Communicate Nuanced Risks To The Great Salt Lake, Matthew D. Laplante, Piyush Dahal, Shih-Yu Simon Wang, Kirsti Hakala, Avik Mukherjee

Plants, Soils, and Climate Faculty Publications

The Great Salt Lake entered the zeitgeist of environmental concern in 2022 when a coalition of scientists and activists warned in a highly publicized report that the lake might be just five years away from complete desiccation, a possibility one state official warned was tantamount to an “environmental nuclear bomb”. Shortly thereafter, an unpredicted and unprecedented pluvial winter resulted in an increase in inflow, temporarily halting the lake’s decline and prompting Utah’s governor to mock the dire prediction as “a joke”, an outcome that speaks to the tension between agenda-setting and trust-building that researchers face when sharing worst-case warnings, particularly …

An Agent-Based Modeling Of Permafrost Melting And Virus Exposure Due To Climate Change, Nishat Ara Mozid

Theses and Dissertations

Climate change has affected human life and natural system significantly. Particularly, there is specific evidence of change in the Arctic region for climate warming. One of the consequences of climate change is the process of permafrost degradation and thawing rate of active layer. Permafrost is defined as frozen grounds that exists at a temperature of or below 0℃ for at least two consecutive years, consists of ice and novel pathogens which are frozen for a long time. Anthrax may cause a serious threat for local environment and livestock due to permafrost melting. The study introduces an agent-based modeling of permafrost …

Supporting High School Students In Their Transition To College Through A Comprehensive College Prep Bootcamp, Brooke E. Baneck

Masters Projects

When transitioning from high school to college, many students struggle with increased academic rigor, time management, and lack of financial literacy, while also facing social and emotional difficulties such as homesickness and stress. Addressing these challenges holistically, this project outlines the Next Step: College Prep Academy, a pre-college bootcamp designed to enhance students' academic preparedness, social integration skills, emotional and psychological health, financial literacy, and cultural competency, particularly for first-generation and minoritized students. Grounded in theoretical perspectives, the bootcamp aims to equip students with essential skills and support systems to thrive in their first year of college and beyond.

Can Simultaneous Integrated Boost Provide Better Dosimetric Coverage Compared To Sequential Boost In Prone Breast Treatment Of Large Breast Volumes?, Kinze Kraft

Masters Projects

Introduction: This study investigates the dosimetric differences between sequential boost (SeB) and simultaneous integrated boost (SIB) techniques in prone breast radiotherapy for patients with large breast volumes, utilizing a 3D-CRT planning technique. Prone positioning in radiotherapy has shown to be effective in reducing heart and lung doses, yet limited research exists to compare overall plan quality between SeB and SIB using this technique. This analysis aims to evaluate whether SIB provides better dosimetric coverage and reduced dose to organs at risk (OARs) compared to SeB in prone breast radiotherapy.

Methods: A retrospective analysis was conducted on data from ten patients …

Two Perspectives On Macroeconomics And Inequality, Aleph Shin

Arts & Sciences Graduate Student Theses and Dissertations

This thesis explores the intricate relationships between macroeconomic forces and economic inequality through two distinct but interconnected lenses. Chapter 1 examines how heightened import competition, a key aspect of globalization, reshapes the occupational structure in the U.S., highlighting the adverse effects of import competition on employment across different occupations, especially those with low and middle wages. Employing industry-level trade and technology measures to assess the impacts on eleven finely defined occupational groups, this chapter reveals that import competition serves as a significant yet often overlooked driver of job polarization and the decline of middle-skill occupations, contrasting with the polarization literature …

Intermittent Clearance Of P21-Highly-Expressing Cells Extends Lifespan And Confers Sustained Benefits To Health And Physical Function, Binsheng Wang, Lichao Wang, Nathan S Gasek, Chia-Ling Kuo, Jia Nie, Taewan Kim, Pengyi Yan, Junyu Zhu, Blake L Torrance, Yueying Zhou, Lisa C Flores, Colton Allen, Allison M Andrade, Chun Guo, Rachel L Cohn, Evan R Jellison, Jenna M Bartley, George A Kuchel, Sheng Li, Tamar Pirtskhalava, Tamar Tchkonia, Sumit Yadav, Laura Haynes, James L Kirkland, Yuji Ikeno, Ming Xu

Faculty, Staff and Student Publications

A key challenge in aging research is to extend lifespan in tandem with slowing down functional decline so that the life with good health (healthspan) can be extended. Here, we show that monthly clearance of a small number of cells, which highly express p21Cip1 (p21high), starting from 20 months improves cardiac and metabolic function, and extends both median and maximum lifespan in mice. Importantly, by assessing health and physical function of these mice monthly until death, we show that clearance of p21high cells improves physical function at all remaining stages of life, suggesting healthspan extension. Mechanistically, …

Decreasing Incivility And Bullying Through The Development Of A Healthy, Respectful Work Culture, Bridgette Wilson

Master's Projects and Capstones

Abstract

Problem: Incidents of bullying and incivility, including verbal aggression and exclusionary practices within the Telemetry department.

Context: This quality improvement project addresses workplace incivility, bullying, and harassment. The project aims to develop and implement a Compact Agreement of Unit Norms to foster a healthier work environment.

Interventions: Interventions included leadership education on bullying and conflict resolution, team awareness was heightened through workshops defining bullying and incivility, and a collaborative Compact Agreement of Unit Norms was developed and implemented.

Measures: An analysis of reported incidents for the first quarter of 2024 through the Electronic Reposting System (ERRF) on the Telemetry …

Undocumented And Unsupported: How College Students Navigate To Meet Their Basic Needs, Mario Alberto Gonzalez

Master's Theses

The cost of attendance at colleges and universities across the United States has risen exponentially year after year. Among these costs include tuition, lodging, food, textbooks, academic materials, and health care, many of which are considered “basic needs” that are ultimately essential for human survival. At the same time, certain groups of students continue to be marginalized and presented with additional barriers in accessing higher education in equitable ways. Undocumented students are one of these groups of students, and are the focus of this study. Although the passage of DACA in 2012 presented opportunities for approximately 800,000 undocumented students, it …

Influence Of Phosphate And Boron Addition To Mixed Liquid Fertilizer On The Growth And Yield Of Red Chili Cultivated In The Subsoil Layer, Stefina Liana Sari, Emma Trinurani Sofyan, Anni Yuniarti

Jurnal Kultivasi

This study assesses the impact of adding phosphate and boron in a mixed liquid fertilizer (MLF) on the growth and yield of red chili plants cultivated in a subsoil environment. The experiment was conducted to comprehend how these nutrients affect the performance of red chili plants, particularly when cultivated in less ideal conditions such as subsoil, a remnant of excavation for brick production. The research was carried out at the Ciparanje Garden of the Faculty of Agriculture, Universitas Padjadjaran. The research design employed a Randomized Completely Block Design with the following treatments: A = Control (degraded soil without fertilizer), B …

Examining Adolescent Sexual Patterns In Creek Town, Nigeria: Insights From A Cross-Sectional Survey And Implications For Tailored Interventions, Rowland Edet, Kabiru K. Salami

Journal of Social, Behavioral, and Health Sciences

In the dynamic landscape of global health, the sexual behaviors of adolescents are of particular significance due to their profound implications for individual well-being and public health. This article focuses on Creek Town, a vibrant community in Nigeria, and aims to provide a nuanced exploration of the sexual behaviors of adolescents within the context of local culture and socio-economic factors. A cross-sectional survey design was employed, involving a multi-stage sampling approach with 422 participants. A comprehensive 112-item questionnaire captured various aspects of adolescent sexual behaviors. Additionally, four focus group discussions, including both in-school and out-of-school adolescents, provided qualitative insights. The …

The Effects Of Online Chemistry-Themed Design-Based Stem Education On Preservice Science Teachers’ Stem Awareness, Emine Sahin Topalcengiz, Burcin Acar-Sesen

Curriculum and Instruction Faculty Publications and Presentations

The study investigated the impact of Chemistry-Focused Online Science, Technology, Engineering, and Mathematics (STEM) teacher education on the awareness of STEM among preservice science teachers. A one-group pretest–posttest quasi-experimental weak design was used to determine changes in preservice teachers’ STEM awareness. During the study, a 14-week Chemistry-Focused Online STEM course was provided to preservice science teachers. As part of this course, the theoretical knowledge about STEM was explained to students, and afterward, they completed two modules. Furthermore, preservice teachers also developed their chemistry-themed STEM lesson plans at the beginning of the course, after explaining theoretical knowledge about STEM at the …

Pkd1 Mutant Clones Within Cirrhotic Livers Inhibit Steatohepatitis Without Promoting Cancer, Min Zhu, Yunguan Wang, Tianshi Lu, Jason Guo, Lin Li, Meng-Hsiung Hsieh, Purva Gopal, Yi Han, Naoto Fujiwara, Darren P Wallace, Alan S L Yu, Xiangyi Fang, Crystal Ransom, Sara Verschleisser, David Hsiehchen, Yujin Hoshida, Amit G Singal, Adam Yopp, Tao Wang, Hao Zhu

Faculty, Staff and Student Publications

Somatic mutations in non-malignant tissues are selected for because they confer increased clonal fitness. However, it is uncertain whether these clones can benefit organ health. Here, ultra-deep targeted sequencing of 150 liver samples from 30 chronic liver disease patients revealed recurrent somatic mutations. PKD1 mutations were observed in 30% of patients, whereas they were only detected in 1.3% of hepatocellular carcinomas (HCCs). To interrogate tumor suppressor functionality, we perturbed PKD1 in two HCC cell lines and six in vivo models, in some cases showing that PKD1 loss protected against HCC, but in most cases showing no impact. However, Pkd1 haploinsufficiency …

Deltex Family E3 Ligases Specifically Ubiquitinate The Terminal Adp-Ribose Of Poly(Adp-Ribosyl)Ation, Matthew Kelly, Chase Dietz, Samuel Kasson, Yong Zhang, Michael J Holtzman, In-Kwon Kim

2020-Current year OA Pubs

Poly(ADP-ribose) polymerases (PARPs) are critical to regulating cellular activities, such as the response to DNA damage and cell death. PARPs catalyze a reversible post-translational modification (PTM) in the form of mono- or poly(ADP-ribosyl)ation. This type of modification is known to form a ubiquitin-ADP-ribose (Ub-ADPR) conjugate that depends on the actions of Deltex family of E3 ubiquitin ligases (DTXs). In particular, DTXs add ubiquitin to the 3'-OH of adenosine ribose' in ADP-ribose, which effectively sequesters ubiquitin and impedes ubiquitin-dependent signaling. Previous work demonstrates DTX function for ubiquitination of protein-free ADPR, mono-ADP-ribosylated peptides, and ADP-ribosylated nucleic acids. However, the dynamics of DTX-mediated …

A Systematic Review Of Diabetic Foot Infections: Pathogenesis, Diagnosis, And Management Strategies, Sabyasachi Maity, Noah Leton, Narendra Nayak, Ameet Jha, Nikhilesh Anand, Kamala Thompson, Danielle Boothe, Alexandra Cromer, Yaliana Garcia, Aliyah Al-Islam

School of Medicine Publications

Background: Diabetic foot infection represents a significant complication of diabetes mellitus, contributing substantially to morbidity, mortality, and healthcare expenditure worldwide. Accurate diagnosis relies on a comprehensive assessment integrating clinical evaluation, imaging studies, and microbiological analysis. Management necessitates a multidisciplinary approach, encompassing surgical intervention, antimicrobial therapy, and advanced wound care strategies. Preventive measures are paramount in reducing the incidence and severity, emphasizing patient education, regular foot screenings, and early intervention.

Methods: The researchers performed a systematic review of literature using PUBMED MESH keywords. Additionally, the study was registered in the International Prospective Register of Systematic Reviews at the Center for Reviews …

Advances In Representation: Interactive Heritage Site Mobile Application On Artworks, Marius Varga, Dena Bazazian

School of Nursing and Midwifery

In this work, we are introducing early technological prototypes of an interactive mobile application aimed at heritage sites and museums. This mobile application will comprise three main components as follows: (1) Image Captioning, (2) Indoor Navigation, and (3) Augmented Reality. To address the Image Captioning component, we aim to build a mobile application for the guidance of heritage site visitors with a caption with relevant information about each artwork. This application can be helpful for visually impaired visitors, and it can provide some extra information about the museum’s objects. We will build this project based on computer vision and AI …

Assessment Approaches For Hemiplegic Shoulder Pain In People Living With Stroke–A Scoping Review, Praveen Kumar, Avgi Christodoulou, Michael Loizou

School of Nursing and Midwifery

Purpose: Hemiplegic shoulder pain (HSP) is reported in up to 40% of people with stroke. Causes of HSP are often multifactorial. To inform appropriate treatment, reliable/valid assessments are critical. The aim of this scoping review was to collate assessment approaches used in studies where the primary outcome was HSP, and to identify how frequently each assessment approach was used. Methods: A systematic search, including studies from 2000-2023 was conducted of the MEDLINE, EMBASE, CINAHL, AMED, Biomed Central, and Cochrane Library databases, with four key terms used: “assess”, “stroke”, “pain” and “shoulder”. All primary studies published in English language fulfilling the …

Role Of Remediation In Cases Of Serious Misconduct Before Uk Healthcare Regulators: A Qualitative Study, Tristan Price, Marie Bryce, Tom Gale, Ellie Reynolds, Oliver Quick, Timothy O'Brien

Peninsula Medical School

Background: The raison d’etre of healthcare profession regulators across the globe is to protect patients and the public from the risk of harm. In cases of serious misconduct, remediation is deemed to be an important factor when considering the risk of harm from a practitioner under investigation. Yet, we know very little about how regulators account for remediation in their decision-making, and whether it is consistent with the aim of risk reduction. This paper explores the role of remediation in decision-making in cases of serious misconduct before UK healthcare regulators. Methods: We conducted interviews with 21 participants from across eight …

Balancing Ecology And Practicality To Rank Waterbodies For Preventative Invasive Species Management, Caleb P. Roberts, William E. Grant, Matthew L. Horton, Lindsey A.P. Labrie, Miranda R. Peterson, Jane S. Rogosh, Hsiao-Hsuan Wang

Biological Sciences Faculty Publications and Presentations

• ‘Early detection and rapid response’ (EDRR) is the most successful framework for preventative invasive species management, but prioritizing localized EDRR actions with limited resources is challenging. An approach that ranks individual locations, such as waterbodies, for EDRR by combining an invasive species' establishment risk with the practicality of managing it could help set reasonable priorities.
• Here, we worked with regional practitioners in Arkansas, USA, and the broader Southeastern USA to co-produce a workflow for preventative aquatic invasive species management that (1) estimates establishment risk under current and future climates with a species distribution model, (2) scores waterbodies according to difficulty …

Stanniocalcin 2 Governs Cancer Cell Adaptation To Nutrient Insufficiency Through Alleviation Of Oxidative Stress, Shuo Qie, Haijuan Xiong, Yaqi Liu, Chenhui Yan, Yalei Wang, Lifeng Tian, Chenguang Wang, Nianli Sang

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Solid tumours often endure nutrient insufficiency during progression. How tumour cells adapt to temporal and spatial nutrient insufficiency remains unclear. We previously identified STC2 as one of the most upregulated genes in cells exposed to nutrient insufficiency by transcriptome screening, indicating the potential of STC2 in cellular adaptation to nutrient insufficiency. However, the molecular mechanisms underlying STC2 induction by nutrient insufficiency and subsequent adaptation remain elusive. Here, we report that STC2 protein is dramatically increased and secreted into the culture media by Gln-/Glc- deprivation. STC2 promoter contains cis-elements that are activated by ATF4 and p65/RelA, two transcription factors activated by …

Whole Genome Sequencing Based Analysis Of Inflammation Biomarkers In The Trans-Omics For Precision Medicine (Topmed) Consortium, Min-Zhi Jiang, Sheila M Gaynor, Xihao Li, Eric Van Buren, Adrienne Stilp, Erin Buth, Fei Fei Wang, Regina Manansala, Stephanie M Gogarten, Zilin Li, Linda M Polfus, Shabnam Salimi, Joshua C Bis, Nathan Pankratz, Lisa R Yanek, Peter Durda, Russell P Tracy, Stephen S Rich, Jerome I Rotter, Braxton D Mitchell, Joshua P Lewis, Bruce M Psaty, Katherine A Pratte, Edwin K Silverman, Robert C Kaplan, Christy Avery, Kari E North, Rasika A Mathias, Nauder Faraday, Honghuang Lin, Biqi Wang, April P Carson, Arnita F Norwood, Richard A Gibbs, Charles Kooperberg, Jessica Lundin, Ulrike Peters, Josée Dupuis, Lifang Hou, Myriam Fornage, Emelia J Benjamin, Alexander P Reiner, Russell P Bowler, Xihong Lin, Paul L Auer, Laura M Raffield, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium, Topmed Inflammation Working Group

Faculty, Staff and Student Publications

Inflammation biomarkers can provide valuable insight into the role of inflammatory processes in many diseases and conditions. Sequencing based analyses of such biomarkers can also serve as an exemplar of the genetic architecture of quantitative traits. To evaluate the biological insight, which can be provided by a multi-ancestry, whole-genome based association study, we performed a comprehensive analysis of 21 inflammation biomarkers from up to 38 465 individuals with whole-genome sequencing from the Trans-Omics for Precision Medicine (TOPMed) program (with varying sample size by trait, where the minimum sample size was n = 737 for MMP-1). We identified 22 distinct single-variant …