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Penguatan Profil Guru Pancasila Melalui Mata Kuliah Etika Dan Profesionalisme Guru, Rina Sari, Dita Permai Sela, Irma Rizki Putri Sutriyanti, Oktavia Gita Cahyani, Retno Asri Dwi Jayantri, Sabrina Anisa Putri, Sa'dun Akbar

Journal of Innovation and Teacher Professionalism

Ethical education and teacher professionalism have an important role in shaping the character and profile of teachers under Pancasila values. However, the implementation of this education in the ed-ucational curriculum often encounters various challenges. The literature review method was used in this research to examine three journals related to strengthening the profile of Pancasila teachers through courses on ethics and teacher professionalism. This research aims to evaluate the effective-ness of courses on ethics and teacher professionalism in instilling and strengthening Pancasila values in prospective candidates. Teacher. The research methods used in the journals reviewed include qualitative with a case study …

Brief Report: Incidence And Outcomes Of Pediatric Tracheal Intubation-Associated Cardiac Arrests In The Icu-Resus Clinical Trial, Akira Nishisaki, Ron Reeder, Elizabeth Laverriere Mcgovern, Tageldin Ahmed, Michael Bell, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph Carcillo, Todd Carpenter, Wesley Diddle, Myke Federman, Ericka Fink, Deborah Franzon, Aisha Frazier, Stuart Friess, Kathryn Graham, Mark Hall, David Hehir, Christopher M Horvat, Leanna Huard, Tensing Maa, Arushi Manga, Patrick Mcquillen, Kathleen Meert, Ryan Morgan, Peter Mourani, Vinay Nadkarni, Maryam Naim, Daniel Notterman, Chella Palmer, Anil Sapru, Carleen Schneiter, Matthew Sharron, Neeraj Srivastava, Shirley Viteri, David Wessel, Heather Wolfe, Andrew Yates, Athena Zuppa, Robert Sutton, Robert Berg

Department of Pediatrics Faculty Papers

BACKGROUND: Tracheal intubation (TI)-associated cardiac arrest (TI-CA) occurs in 1.7% of pediatric ICU TIs. Our objective was to evaluate resuscitation characteristics and outcomes between cardiac arrest patients with and without TI-CA.

METHODS: Secondary analysis of cardiac arrest patients in both ICU-RESUS trial and ancillary CPR-NOVA study. The primary exposure was TI-CA, defined as cardiac arrest occurred during TI procedure or within 20 min after endotracheal tube placement. The primary outcome was survival to hospital discharge with favorable neurological outcome (Pediatric Cerebral Performance Category score 1-3 or unchanged).

RESULTS: Among 315 children with cardiac arrests, 48 (15.2%) met criteria for TI-CA. …

Predicting Poor Mental Health Among Older Syrian Refugees In Lebanon During The Covid-19 Pandemic: A Nested Cross-Sectional Study, Berthe Abi Zeid, Leen Farouki, Tanya El Khoury, Abla M. Sibai, Carlos Mendes F. De Leon, Marwan F. Alawieh, Zeinab Ramadan, Sawsan Abdulrahim, Hala Ghattas Ph.D., Stephen J. Mccall

Faculty Publications

Background: Post-term pregnancy, defined as reaching or exceeding 42 + 0 weeks of gestation, is known to be associated with unfavourable birth outcomes. High-income countries have responded to this risk by widely adopting labour induction protocols in late-term, but many low- and middle-income countries have not. However, understanding underlying mechanisms linking post-term births to adverse newborn and infant outcomes remains limited.

Objective:To investigate the (a) prevalence of post-term, (b) the risk factors associated with post-term (c) the association between post-term births and the risk of smallfor-gestational-age (SGA) neonates and of infant mortality in middle-income settings.

Methods:We used existing …

From Within The Walls Of The Ivory Tower: Understanding The Differences In The Effects Of The Research Training Environment And Mentor Race-Matching On Pursuing An Academic Career Between White And Bipoc Counseling Psychologists, Shruthi Jayashankar

Seton Hall University Dissertations and Theses (ETDs)

A 2020 report published by American Psychological Association’s Division 45 Society for the Psychological Study of Culture, Ethnicity, and Race highlighted that although BIPOC contributions in research and scholarship have propelled innovative and revolutionary breakthroughs in the field of psychology, they consistently continue to be discounted by the overall White Eurocentric perspectives propelled by the “ivory tower.” From being minoritized in demographic representation, to falling out of the academic pipeline due to various stressors and barriers to success, the academe of psychology still seems to reflect a deficit in its facilitation of BIPOC psychologists.

This dissertation study addressed this phenomenon …

Impact Of Work From Home Factors On Employee Work Engagement, Okoye Shedrach Obumneme, Muhammad Nizam Zainuddin

International Journal of Management, Finance and Accounting

The aim of the study is to examine the various work from home related factors which help in bringing about improved employee work engagement based on the work assigned to them. The study employed a quantitative research approach, positivism research philosophy, and case study research design. The study made use of 201 participants, with data collected through questionnaire and online survey tool (Google Form). Participants for the study were sampled from AmIT Global Solutions, AppCable Sdn Bhd, IWG 3.2, Regus Management Malaysia Sdn Bhd, Deventure Sdn Bhd, and Texas Instruments. Thethree hypotheses proposed in the study were examined using multiple …

Attracting Foreign Direct Investment (Fdi) In Madani Economy: What Factors Matter?, Yi-Shan Chong, Chee-Lip Tee

International Journal of Management, Finance and Accounting

Foreign Direct Investment (FDI) has long been acknowledged as a vital driver of economic development, and Southeast Asia stands out as a prime destination for such investments. However, Malaysia's share of FDI in the region has been diminishing, signalling a loss of competitiveness. In response, the Malaysian government has prioritized enhancing competitive strength in its recent development framework, Madani Economy. This study aims to shed light on the factors that require greater attention to achieve these objectives. Utilizing the Autoregressive Distributed Lag (ARDL) approach and monthly data spanning from 2010 to 2019, the findings underscore the importance of growing market …

Circe’S Struggle To Fight Against Beauty Standards In Madeline Miller’S Circe: A New Criticism Study, Mutiara Anugerah Pekerti, Usma Nur Dian Rosyidah, Rizal Oktovianto Datau

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

Beauty standards are a cultural technique used to determine what is considered beautiful. Circe, Madeline Miller's story, exhibits a type of bias known as the beauty standard. Circe, the novel's main character and the daughter of Helios, the Sun God, is the subject of this study. Circe, the main character in this story, is treated differently, especially by her siblings, because she lacks the beautiful ap-pearance and power of other Helios' children and ladies in her life. The goal of this study is to explain the cause of Circe's prejudice despite her upper-class status, the impact of beauty standards in …

Effect Of Tibial Malrotation On Anterior And Posterior Cruciate Ligaments In Bicruciate-Retaining Total Knee Arthroplasty, Muhammad Saakeereen Sa’Audi, Abdul Halim Abdullah, Solehuddin Shuib, Muhammad Azim Mat Raffei, Mohd Fairudz Mohd Miswan, Mohd Afzan Mohd Anuar

Makara Journal of Technology

Osteoarthritis (OA) is a musculoskeletal disorder specified as a joint disease that affects mostly human joints worldwide. Total knee arthroplasty (TKA) is performed to restore the affected joint and relieve the symptoms. However, tibial malrotation, which is one of the most common errors in TKA, results in poor function of the implant and pain after the procedure. People with OA often experience limited mobility and cannot accomplish daily tasks. Finite element analysis (FEA) has been widely applied to interpret the biomechanical and kinematic force along the joint and investigate the cruciate ligament’s mechanical behavior. Unfortunately, one of the problems in …

Inevitable Or Preventable? A Pilot Intervention To Reduce Burnout Risk In Acute Care Nurses, Emily R. Kelly

Clinical Psychology Dissertations

Purpose: Burnout among healthcare workers is widespread and costly, resulting in calls for action to reduce the experience and impact of this work-related phenomenon. Burnout among nurses has been associated with impaired patient safety, decreased quality of care, lower levels of patient satisfaction, decreased productivity, and higher levels of intent-to-leave the profession. Aim: The aims of this study are to assess whether sleep problems mediate the relationship between recovery and burnout and to examine the feasibility of a pilot intervention to enhance recovery, improve sleep quality, and reduce burnout among inpatient nurses. Method: Eligible participants included registered nurses who worked …

On The Optimization Of Sensors For The Remote Sensing Of Crop Yield, Nathan M. Burglewski

Theses

Remote sensing has long been a part of precision agriculture research, with products related to spatially-explicit, within-field management of yield, disease, and harvest scheduling, to name a few application areas that are of interest to industry. A variety of spaceborne, airborne, and in-situ sensors are used to monitor crop health throughout the growing season, inform management decisions for farmers, and dictate logistical or planning operations. Crop yield forecasting, specifically, comes in many forms, but recently machine learning algorithms have gained prominence, at the cost of more traditional parametric regression models. While much work has been accomplished towards grain yield estimation …

Introducing Therapeutic Music As An Alternative Therapy To Reduce Anxiety In The Emergency Department, Azuka Debbie Onyekwe

Doctor of Nursing Practice Final Project Abstract

Purpose: This quality improvement project evaluated the feasibility of implementing therapeutic music in the emergency department (ED) to decrease anxiety levels by 10% over three months at a hospital in West Houston.

Background: Anxiety in the ED can exacerbate patient conditions and lead to increased use of anxiolytic drugs. Prior studies suggest that therapeutic music is effective in lowering anxiety across clinical settings. Anxiety in emergency department settings can negatively impact patient outcomes and increase reliance on pharmacological treatments. Evidence from previous research has demonstrated that therapeutic music interventions can significantly reduce anxiety, making it a promising non-pharmacological approach. However, …

Dental Health Status And Associated Factors In The Deprived Population Covered By Rural Dental Insurance Program In The Province Of Kerman/Iran, Asma Sabermahani, Mohammad Jafari Sirizi, Zinab Shaker, Rasool Hassanzadeh, Tayebeh Malekmohammadi, Naimeh Hasheminejad

Journal of Dentistry Indonesia

Tooth decay is a widespread disease with considerable financial and psychological costs. Objective: The aim of this study was to investigate dental health of a large sample of people covered by rural insurance program in Kerman province. Methods: A sample size of 5000 was determined among people living in villages and towns with a population of less than 20000 who are all covered by dental rural insurance program. The DMFT/dmft index was assessed in five target age groups using the WHO oral health measurement standard form. Demographic and socioeconomic status of participants was also recorded. The percentage of …

Hyaluronic Acid In Managing Deep Residual Pockets In Stage Iii-Iv Periodontitis: A Randomized Controlled Trial, Mohamad Adib Jaafar, Esther Voo Vui Ching, Sharul Nisha Ali, Jeyanthi Subramaniam, Yuhaniz Ahmad Yaziz

Journal of Dentistry Indonesia

Objective: The purpose of this study was to determine the adjunctive clinical effect of hyaluronic acid (HA) in the non-surgical treatment of subjects with residual pockets (≥ 6 mm) at the maintenance phase. Methods: 36 systemically healthy subjects in the periodontal maintenance phase were included in this 3-month randomized clinical trial. Subjects received a course of full-mouth, scaling and root debridement (SRD). In the test group (n = 18), HA 0.8% was applied subgingivally immediately after SRD. The control group (n = 18) was treated with SRD only. Subjects in both groups were required to apply HA 0.2% …

Analysis Of Bone Destruction Mechanism By Aggregatibacter Actinomycetemcomitans: A Systematic Review, Erik Idrus, Karenina Raihani Amalia Ardiman, Widya Lestari, Masita Mandasari, Sri Angky Soekanto

Journal of Dentistry Indonesia

Periodontitis is a disease marked by inflammation of the periodontium, caused by biofilms present in the oral cavity, and results in alveolar bone destruction. One of the main hallmarks of periodontitis is the presence of Aggregatibacter actinomycetecomitans, which is generally suppressed by antibiotic administration. The strategy to control A. actinomycetecomitans by small specific peptide inhibitors potentially halts the progression of alveolar bone damage while lowering the risk of antibiotic resistance. The detailed interaction mechanisms of A. actinomycetecomitans and bone cells are fundamental to discovering and constructing the specific inhibitor. Objective : To systematically review the mechanism of bone destruction by …

Role Of Titanium-Reinforced Platelet-Rich Fibrin In Periodontal Tissue Regeneration-A Systematic Review, Bhavya Manchala, Anurag Teju, Mohan Kumar Pasupuleti, Gautami S Penmetsa, Sruthima Gottumukkala, Venkata Lakshmi

Journal of Dentistry Indonesia

Objective: The objective of the study is to demonstrate the efficacy of Titanium reinforced platelet-rich fibrin (T-PRF) as the sole biomaterial amongst the biologics in periodontal regeneration of both soft and hard tissues. Methods: A PUBMED database search is conducted from August 2013 to August 2023. Only original articles, including Randomized controlled clinical trials, cross-sectional studies, prospective studies, and case-control studies, were included. The studies will be analyzed regarding the outcome of the association between T-PRF and periodontal regeneration of both hard and soft tissue. Results: From 35 articles identified, 8 RCTs were included. The use of …

Avicennia Marina Mangrove Plant Mediated Selenium Nanoparticles And Their Therapeutic Activity Against Oral Pathogens And Other Biological Properties, Kannan Kamala, Pitchiah Sivaperumal, Dhanraj Ganapathy

Journal of Dentistry Indonesia

In the last few decades nanoparticles are widely used in the control of many pathogenic bacteria, fungi, viruses, and cancer growth both in-vitro and in-vivo. A marine plant of Avicennia marina is widely used in traditional medicine for diabetes, inflammation and skin diseases. Objective: In general Avicennia marina has been used as a traditional medicine to treat various diseases and it has shown significant inhibition against various pathogen and the formation of free radicals. Also, the plant A.marina mediated selenium nanoparticles has therapeutic activity has promising to develop biocompatible new cost effective treatment for various oral diseases. Methods: …

Remineralization Potential Of Grape Seed Extract On Artificial Enamel Caries Lesions, Serif Alpcan Ozden, Esra Oz

Journal of Dentistry Indonesia

Objective: This study aimed at a comparative analysis of the remineralization potential of grape seed extract (GSE) alone, together with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and/or acidulated phosphate fluoride (APF). Methods: The samples were randomly divided into seven groups according to the treatment used: 25% GSE, 1.23% APF (Gelato APF gel), and CPP-ACP (GC Tooth Mousse). The samples in group 7 received no treatment as a control group. All specimens were subjected to pH cycling for two weeks. Surface microhardness analyses were performed at baseline, after demineralization and remineralization. Data were analyzed using one-way analysis of variance (ANOVA), …

In Silico Modelling And Docking Simulation Of Egfr-Targeted Diphtheria Toxin Chimera With Various Targeting Moieties, Muhammad Afif Naufal Bmed, Benedictus Ansell Susanto Bmed, Talitha Dinda Gunawan Bmed, Azhar Ridha Lukman Bmed, Alifa Rahma Rizqina Bmed, Muhammad Misbahul Fuad Bmed

Indonesian Journal of Medical Chemistry and Bioinformatics

Introduction: Cancer is a major etiology of death worldwide due to high mortality and suboptimal medicine. However, an emerging field, targeted therapy enabled a more selective and effective therapeutic action. This article aims to analyze in-silico the hypothetical targeted therapy agent that is combinations of conjugate consisting of EGFR targeting moieties and diphtheria toxin (DT-390).

Method: Our novel peptide is a conjugate of a novel EGFR targeting peptide and DT-390, forming a chimera. The tertiary structure was predicted using AlphaFold 2.0. The best IDDT scoring and stereochemistry profiles were utilized. The HADDOCK2.4 webserver modelled the docking between our …

Unveiling Environmental Justice In Two Us Cities Through Greenspace Accessibility And Visible Greenness Exposure, Md Shahinoor Rahman, Mahbubur Meenar, S. M. Labib, Ted Howell, Deepti Adlakha, Ben Woodward

School of Public Health Faculty Publications

Uneven access to greenspaces or visible greenness is an environmental justice (EJ) issue. In this paper, we use a social equity lens to develop geospatial models that measure convenient walking access to urban greenspaces such as parks and street-level green exposure en route to greenspaces. We utilized earth science, geospatial, and demographic datasets to develop two models—Greenspace Accessibility and Visible Greenness Exposure—and applied them in Camden and Jersey City, USA, two communities experiencing environmental injustices. Modeling results show that greenspace accessibility is a concern in both cities, with Jersey City experiencing more prominent disparities. We observed significant positive relationships in …

The State Of The Unions 2024: A Profile Of Organized Labor In New York City, New York State, And The United States, Ruth Milkman, Joseph Van Der Naald

Publications and Research

This report released by the CUNY School of Labor and Urban Studies, State of the Unions 2024: A Profile of Organized Labor in New York City, New York State, and the United States, is a part of an annual publication series, documents recent trends in unionization patterns. The CUNY School of Labor and Urban Studies’ latest annual report on unionization patterns shows that private-sector union organizing efforts continued to increase across the country over the last year. The report documents that growth in union election petitions since 2020 has reversed a decade of decline, reaching a level not seen since …

Rasch Validation Of Arabic Scale Of Mental Health (Asmh) In Indonesian Version To Measure Adolescent Mental Health, Dody Hartanto, Mufied Fauziah, Yenni Rizal, Imam Azhari, Ratu Matahari, Parhan Fauzan, Nuri Cholidah Hanum, Diki Herdiansyah

Jurnal Kajian Bimbingan dan Konseling

Mental health is a crucial aspect for adolescents, as those with poor mental health may experience conditions ranging from depression and anxiety disorders to suicidal tendencies. Identifying mental health issues is essential, necessitating an instrument to assess adolescent mental health. This study aims to adapt the Arabic Scale of Mental Health (ASMH) into Indonesian and evaluate its validity using the Rasch model. The adaptation process followed the Procedures and Guidelines for Translating Counselling Assessment as outlined by Lenz, Gómez Soler, Dell'Aquilla, and Uribe. The translated instrument was administered to 685 high school and vocational school students from Yogyakarta. The instrument …

Relationship Between Academic Burnout And Academic Resilience Manifest In Prospective Counselors During The New Normal Era, Indriyana Rachmawati, Moh Farozin, Agus Basuki

Jurnal Kajian Bimbingan dan Konseling

Academic resilience has become an interesting topic of discussion as a result of the increase in academic burnout experienced by prospective counselors recently as a result of increasing academic assignments. Prospective counselors who experience academic burnout generally have poor academic resilience because they feel tired or bored with academic tasks while still studying, and this has an impact on the resulting performance. This research aims to determine the relationship between academic burnout and the academic resilience of prospective counselors. We used a quantitative research method, employing a correlation research design, to reveal the relationship between the two. The research sample …

Development Of Metaverse-Based Virtual Reality Counseling: Technology-Assisted Psychological Services For Students With Disabilities, Imam Ariffudin, Muhammad Nur Hudha, Akhmad Zaini, Ajeng Intan Nur Rahmawati

Jurnal Kajian Bimbingan dan Konseling

This study aims to develop a metaverse-based Virtual Reality Counseling (VRC) medium to support psychological services for students with special needs. The research method used is the research and development method with the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation). The results show that the metaverse-based VRC medium has met the media acceptability aspects, making it feasible for effective implementation. Additionally, experimental results indicate a decrease in the levels of mental health disorders experienced by the counselees after undergoing individual counseling assisted by the metaverse-based VRC medium. The impact of this study suggests that the metaverse-based VRC medium is …

Boosting Teacher Work Engagement: The Role Of Self-Efficacy, Resilience, And Personality Traits, Ajar Dirgantoro, Nur Eva, Fattah Hanurrawan, Imanuel Hitipeuw

Jurnal Kajian Bimbingan dan Konseling

The role of a teacher in the world of education greatly affects how the quality of students with the expected changes cannot be separated from the responsibility of a teacher in educating, guiding, motivating and being a facilitator for these students. However, low work involvement by teachers is not able to achieve organizational or school success in producing quality successors. The intended work engagement is a series of results from the teacher's self-efficacy and resilience towards himself and work tasks. This study aims to empirically examine the effect of self-efficacy and resilience on teacher work engagement with personality traits as …

Psychological Dynamics Among Adolescents With Self-Harm Behavior Based On Rational Emotive Behavior Therapy, Hengki Tri Hidayatullah, Arbin Janu Setiyowati, Irene Maya Simon, Riyani Indriyati, Maria Teresa Mattingly

Jurnal Kajian Bimbingan dan Konseling

The objective of this study was to ascertain the psychological underpinnings of self-harm behaviors among adolescents, with a particular emphasis on the tenets of rational emotive behavior therapy (REBT). Additionally, this study aimed to elucidate the various forms of self-harm behaviors and the underlying factors that contribute to these behaviors in adolescents. This research employed a qualitative approach with a phenomenological research design. The research subjects were students at State Senior High School 1 Batu, Indonesia, selected based on certain criteria in accordance with the research needs (purposive sampling). The results demonstrate three key aspects of the psychological dynamics of …

Stie: Single-Cell Level Deconvolution, Convolution, And Clustering In In Situ Capturing-Based Spatial Transcriptomics, Shijia Zhu, Naoto Kubota, Shidan Wang, Tao Wang, Guanghua Xiao, Yujin Hoshida

Faculty, Staff and Student Publications

In in situ capturing-based spatial transcriptomics, spots of the same size and printed at fixed locations cannot precisely capture the randomly-located single cells, therefore inherently failing to profile transcriptome at the single-cell level. To this end, we present STIE, an Expectation Maximization algorithm that aligns the spatial transcriptome to its matched histology image-based nuclear morphology and recovers missing cells from ~70% gap area, thereby achieving the real single-cell level and whole-slide scale deconvolution, convolution, and clustering for both low- and high-resolution spots. STIE characterizes cell-type-specific gene expression and demonstrates outperforming concordance with true cell-type-specific transcriptomic signatures than the other spot- …

Micronuclear Collapse From Oxidative Damage, Melody Di Bona, Yanyang Chen, Albert S Agustinus, Alice Mazzagatti, Mercedes A Duran, Matthew Deyell, Daniel Bronder, James Hickling, Christy Hong, Lorenzo Scipioni, Giulia Tedeschi, Sara Martin, Jun Li, Aušrinė Ruzgaitė, Nadeem Riaz, Parin Shah, Edridge K D'Souza, D Zack Brodtman, Simone Sidoli, Bill Diplas, Manisha Jalan, Nancy Y Lee, Alban Ordureau, Benjamin Izar, Ashley M Laughney, Simon Powell, Enrico Gratton, Stefano Santaguida, John Maciejowski, Peter Ly, Thomas M Jeitner, Samuel F Bakhoum

Faculty, Staff and Student Publications

Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear rupture catalyzes chromosomal rearrangements, epigenetic abnormalities, and inflammation, yet mechanisms safeguarding micronuclear integrity are poorly understood. In this study, we found that mitochondria-derived reactive oxygen species (ROS) disrupt micronuclei by promoting a noncanonical function of charged multivesicular body protein 7 (CHMP7), a scaffolding protein for the membrane repair complex known as endosomal sorting complex required for transport III (ESCRT-III). ROS retained CHMP7 in micronuclei while disrupting its interaction with other ESCRT-III components. ROS-induced cysteine oxidation stimulated CHMP7 oligomerization and …

Identification Of A0 Minimum Ablative Margins For Colorectal Liver Metastases: Multicentre, Retrospective Study Using Deformable Ct Registration And Artificial Intelligence-Based Autosegmentation, Iwan Paolucci, Jessica Albuquerque Marques Silva, Yuan-Mao Lin, Gregor Laimer, Valentina Cignini, Francesca Menchini, Marcio Meira, Alexander Shieh, Caleb O'Connor, Kyle A Jones, Carlo Gazzera, Paolo Fonio, Kristy K Brock, Marco Calandri, Marcos Menezes, Reto Bale, Bruno C Odisio

Faculty, Staff and Student Publications

Background: Several ablation confirmation software methods for minimum ablative margin assessment have recently been developed to improve local outcomes for patients undergoing thermal ablation of colorectal liver metastases. Previous assessments were limited to single institutions mostly at the place of development. The aim of this study was to validate the previously identified 5 mm minimum ablative margin (A0) using autosegmentation and biomechanical deformable image registration in a multi-institutional setting.

Methods: This was a multicentre, retrospective study including patients with colorectal liver metastases undergoing CT- or ultrasound-guided microwave or radiofrequency ablation during 2009-2022, reporting 3-year local disease progression (residual unablated tumour …

Inhibition Of Ulk1/2 And Kras G12c Controls Tumor Growth In Preclinical Models Of Lung Cancer, Phaedra C Ghazi, Kayla T O'Toole, Sanjana Srinivas Boggaram, Michael T Scherzer, Mark R Silvis, Yun Zhang, Madhumita Bogdan, Bryan D Smith, Guillermina Lozano, Daniel L Flynn, Eric L Snyder, Conan G Kinsey, Martin Mcmahon

Faculty, Staff and Student Publications

Mutational activation of KRAS occurs commonly in lung carcinogenesis and, with the recent U.S. Food and Drug Administration approval of covalent inhibitors of KRASG12C such as sotorasib or adagrasib, KRAS oncoproteins are important pharmacological targets in non-small cell lung cancer (NSCLC). However, not all KRASG12C-driven NSCLCs respond to these inhibitors, and the emergence of drug resistance in those patients who do respond can be rapid and pleiotropic. Hence, based on a backbone of covalent inhibition of KRASG12C, efforts are underway to develop effective combination therapies. Here, we report that the inhibition of KRASG12C signaling increases autophagy in KRASG12C-expressing lung cancer …

Cyber Crime Against Women's Personal Data On Online Platforms And The Role Of Pdp Laws, Ambar Alimatur Rosyidah, Farah Fajriyah, Rahayu Rahayu

JURNAL KOMUNIKASI INDONESIA

The presence of online platforms such as financial technology lending platforms is like a double-edged knife for women. These platforms pave the way for restrictions on women accessing loans. However, the use of fintech poses risks to women. They become victims of cybercrime with the existence of desk collectors who collect online loans and the third party who use the women's data. This study aims to examine the cybercrime implications of using fintech experienced by women related to fintech lending and then explore the role, data protection, and scope of the PDP Law as a solution. This study uses Qualitative …