Digital Commons Network^™

Semen Analysis Of Covid-19 Survivors And Uninfected Men: Examining The Motility, Concentration, Vitality, And Morphology Parameters Of Spermatozoa, Sri Musta'ina, Eko Budi Siswidiyanto, Pety Narulita, Agustinus, Aucky Hinting, Atika, Zakiyatul Faizah

Folia Medica Indonesiana

Highlights:
1. Spermatozoa can be affected by coronavirus disease 2019 (COVID-19) due to a disruption in spermatogenesis, leading to a decline in semen quality.
2. This study compared the semen quality of COVID-19 survivors and those who had not been infected with COVID-19, specifically on the first spermatogenesis cycle following the confirmation of COVID-19 infection.
3. This study is distinctive since no previous research in Indonesia has examined the semen quality parameters, such as the concentration, morphology, motility, and vitality of spermatozoa, in men who had a COVID-19 infection.

Abstract
Semen quality in COVID-19 patients shows inconsistencies and variations. This …

Analysis Of Risk Factors Associated With The Incidence Of Placenta Accreta At An Indonesian Tertiary Hospital, Aisha Grayli Cahyani, Willy Sandhika, Gatut Hardianto

Folia Medica Indonesiana

Highlights:
1. The increased incidence of placenta accreta is contributed significantly by parity classification, a history of cesarean section, body mass index, and interbirth interval.
2. The findings of this study can be used as an additional reference in determining the risk of placenta accreta in pregnant women, specifically as an input in screening and antenatal care programs for pregnant women to provide early detection and appropriate management.


Abstract
The incidence of placenta accreta during pregnancy constitutes a serious problem in reproductive health. This complication has increased significantly over the last few decades, especially in developed countries where cesarean deliveries …

Larvicidal Effect Of Breadfruit (Artocarpus Altilis) Flower Extract Against Aedes Aegypti, Ni Wayan Winianti, Putu Indah Budi Apsari, Ni Kadek Meta Jayanti

Folia Medica Indonesiana

Highlights:
1. This study attempted an experiment on the novel invention of a naturally sourced larvacide, specifically breadfruit (Artocarpus atilis) flower extract, against Aedes aegepti.
2. The findings of this study suggest that breadfruit flower extract can serve as an effective larvacide, as evident by an increased mortality rate of Aedes aegepti larvae.


Abstract
Dengue hemorrhagic fever remains a major problem in Indonesia. The mosquito that spreads this disease is the Aedes aegypti species. The use of larvicides is a viable method to inhibit the growth of larvae into adult mosquitoes. The flowers of breadfruits (Artocarpus atilis) have long been …

Chronic Guillain-Barré Syndrome From Misdiagnosed Lyme Disease, Carlos H. Cisneros Jr, Alberto E. Almeida

MEDI 9331 Scholarly Activities Clinical Years

Lyme disease (borreliosis) is caused by transmission of Borrelia burgdorferi from deer ticks in the United States. Neurological symptoms can manifest in the early disseminated stage of the disease and have the worst involvement in the late dissemination stage. Few, but important case reports exist of patients experiencing disseminated Lyme with associated Guillain-Barre Syndrome (GBS). GBS manifests as an ascending flaccid paralysis with additional sensory deficits and is characterized as an immune-mediated polyneuropathy attacking the peripheral nervous system. A college-aged, wheelchair bound, quadriplegic female presented to the clinic to establish care in October 2023. She reported being bitten by a …

The Effectiveness Of The Gnana Laryngeal Mask Airway Ii (Gla-Ii) With Novel Suction Tubing In Gastrointestinal (Gi) Cases, Shahab Ahmadzadeh, Landyn D. Johnson, William T. Barham, James Ilochi, Matthew Fredericks, Giustino Varrassi, Sahar Shekoohi, Alan D. Kaye

School of Medicine Faculty Publications

INTRODUCTION: The Gnana laryngeal mask airway II (GLA-II) is a supraglottic airway device similar to the classic laryngeal mask airway, except it has an additional suction port. This suction port allows for the removal of secretions and saliva. A previous version of the Gnana laryngeal airway 4 was made of silicone, while this newer version is made of polyvinyl chloride (PVC), which is more affordable. This study aimed to demonstrate the effectiveness and tolerability of this PVC-designed GLA-II and evaluate its ability to suction secretions. METHODS: The prospective cohort study included 100 gastrointestinal (GI) cases to determine the effectiveness and …

Early Experience And Perioperative Risk Of Gammatile For Upfront Brain Metastases: Report From A Prospective Multicenter Study, Rupesh Kotecha, Manmeet Ahluwalia

All Publications

Background: GammaTile (GT), a form of brachytherapy utilizing cesium-131 seeds in a bioresorbable collagen tile, has gained popularity for the treatment of recurrent intracranial tumors and more recently for newly diagnosed metastases. This study reports early experience utilizing GT in upfront brain metastases with a focus on clinical applications and perioperative safety.

Methods: The STaRT Registry (NCT04427384) was queried for all patients receiving GT for upfront metastases from August 2021 to August 2023. Data regarding patient demographics, procedure details, and adverse events (AEs) were extracted and analyzed.

Results: Twenty-eight patients, median age 65 years (range 28-81), with 30 …

The Prospector, September 10, 2024, Utep Student Publications

The Prospector

No abstract provided.

Synthesis, Antiproliferative Activity And Molecular Docking Studies Of Neo‑ And Isocryptolepine Conjugates, Asmaa Taha

Nanotechnology Research Centre

A series of twelve conjugates 9a-c, 10a-c, 11a-c, and 12a-c based on naturally occurring neo- and isocryptolepines I and II were synthesized and characterized. The synthetic pathways involved nucleophilic substitution reaction of the preprepared amines 4a-c and 5a-c with 1-(4-bromobutyl)indole derivatives 8a and 8b, respectively, in aprotic solvent under heating. The structures of the synthesized conjugates were elucidated by FTIR, ¹H NMR, ¹³C NMR, and MS spectrometry and showed data consistence with the expected structures. The antiproliferative activity of 9a-c, 10a-c, 11a-c and 12a-c was evaluated against HepG-2 and HCT-116 cancer cell lines using normal …

2024-10-09 Caps Expands Services In Response To Student Feedback, James Miller

The Spectator Online

No abstract provided.

Analyzing The Dosimetric Impact Of Ct Artifacts From High-Density Objects In Radiotherapy Planning, Stephen Reed

All ETDs from UAB

High-density objects such as prosthetics, cardiac implanted devices, or surgical clips can create artifacts in computed tomography (CT) images used for radiotherapy planning, leading to regions of inaccurate CT information. These high-density objects may cause artifacts that can impact the accuracy of dose calculations for radiotherapy treatment plans and may require large amounts of a clinician’s time to manually override. Previous research shows that larger ranges of CT numbers can impact the accuracy of dose calculations and that different dose calculations algorithms handle artifacts in CT images differently. Manual correction of voxels affected by high-density objects in CT scans is …

Examining Sense Of Belonging In Higher Education Leadership For Black Women With Intersecting Marginalized Identities, Dominique A. White

Walden Dissertations and Doctoral Studies

Black women juggling marginalized minority identities in executive leadership at public four-year universities contend with stigmas associated with race and gender, contributing to a decreased sense of belonging. Significant research has been done about the journeys of Black or African American women as they seek executive roles in higher education. However, minimal research explores Black women's sense of belonging once executive leadership status is reached. Understanding their sense of belonging could fill a gap in practice regarding Black women’s scarcity occupying executive university leadership. This qualitative study examined the perceptions of a sense of belonging for Black women juggling intersecting …

Knocking Out Amr Project Review, Lovleen Tina Joshi, Catrin E. Moore

Peninsula Dental School

No abstract provided.

Fentanyl: Social Somanaesthetic, Valery Vino

Contemporary Aesthetics (Journal Archive)

No abstract provided.

Big Geospatiotemporal Data Approaches To Monitoring And Mitigating Environmental Impacts In Agriculture, Olatunde D. Akanbi, Vibha S. Mandayam, Erika I. Barcelos, Arafath Nihar, Yinghui Wu, Jeffrey Yarus, Roger H. French

Student Scholarship

This research explores the application of geospatial techniques for global agricultural monitoring, integrating satellite imagery and soil data to assess crop health and soil conditions. Our approach provides actionable insights to improve agricultural productivity and sustainability, addressing food security challenges through advanced machine learning models.

A Multivariate To Multivariate Approach For Voxel-Wise Genome-Wide Association Analysis, Qiong Wu, Yuan Zhang, Xiaoqi Huang, Tianzhou Ma, L Elliot Hong, Peter Kochunov, Shuo Chen

Faculty, Staff and Student Publications

The joint analysis of imaging-genetics data facilitates the systematic investigation of genetic effects on brain structures and functions with spatial specificity. We focus on voxel-wise genome-wide association analysis, which may involve trillions of single nucleotide polymorphism (SNP)-voxel pairs. We attempt to identify underlying organized association patterns of SNP-voxel pairs and understand the polygenic and pleiotropic networks on brain imaging traits. We propose a bi-clique graph structure (ie, a set of SNPs highly correlated with a cluster of voxels) for the systematic association pattern. Next, we develop computational strategies to detect latent SNP-voxel bi-cliques and an inference model for statistical testing. …

A Smart Water Bottle And Companion App (Hidratespark 3) To Improve Bladder-Filling Compliance In Patients With Prostate Cancer Receiving Radiotherapy: Nonrandomized Trial Of Feasibility And Acceptability, William Jin, Christopher Montoya, Benjamin James Rich, Crystal Seldon Taswell, Miguel Noy, Deukwoo Kwon, Benjamin Spieler, Brandon Mahal, Matthew Abramowitz, Raphael Yechieli, Alan Pollack, Alan Dal Pra

Faculty, Staff and Student Publications

Background: Patients with prostate cancer undergoing radiation therapy (RT) need comfortably full bladders to reduce toxicities during treatment. Poor compliance is common with standard of care written or verbal instructions, leading to wasted patient value (PV) and clinic resources via poor throughput efficiency (TE).

Objective: Herein, we assessed the feasibility and acceptability of a smartphone-based behavioral intervention (SBI) to improve bladder-filling compliance and methods for quantifying PV and TE.

Methods: In total, 36 patients with prostate cancer were enrolled in a single-institution, closed-access, nonrandomized feasibility trial. The SBI consists of a fully automated smart water bottle and smartphone app. Both …

The Neurogenic Effects Of Pasak Bumi (Eurycoma Longifolia Jack) And Seluang Fish (Rasbora Spp.) In Malnutrition-Induced Rat, Didik Dwi Sanyoto, Triawanti, Meitria Syahadatina Noor, Dimas Ikhsan Airlangga

Folia Medica Indonesiana

Highlights:
1. This study analyzed the effects of using locally sourced pasak bumi extract and seluang fish on the parameters of neurogenesis in malnourished rat models.
2. It promotes further exploration into modified treatments for malnutrition, emphasizing nutritional strategies that harness locally available natural resources.


Abstract
Early developmental malnutrition exerts adverse effects on the structural, neurochemical, and neurophysiological maturation of cerebral cells by disrupting the process of neurogenesis. Pasak bumi (Eurycoma longifolia Jack) and seluang fish (Rasbora spp.), two indigenous natural resources of South Kalimantan, Indonesia, are believed to harbor nutritional components capable of mitigating these deleterious effects. We aimed …

Neuroinflammation And Brain Health Risks In Veterans Exposed To Burn Pit Toxins, Athena Brooks, Brian Sandri, Joshua Nixon, Timothy Nurkiewicz, Paul Barach, Janeen Trembley, Tammy Butterick

College of Population Health Faculty Papers

Military burn pits, used for waste disposal in combat zones, involve the open-air burning of waste materials, including plastics, metals, chemicals, and medical waste. The pits release a complex mixture of occupational toxic substances, including particulate matter (PM), volatile organic compounds (VOCs), heavy metals, dioxins, and polycyclic aromatic hydrocarbons (PAHs). Air pollution significantly impacts brain health through mechanisms involving neuroinflammation. Pollutants penetrate the respiratory system, enter the bloodstream, and cross the blood-brain barrier (BBB), triggering inflammatory responses in the central nervous system (CNS). Chronic environmental exposures result in sustained inflammation, oxidative stress, and neuronal damage, contributing to neurodegenerative diseases and …

Re: Butte Reduction Works (Brw) Phase Iii Quality Assurance Project Plan (Qapp) Request For Change Brw-2024-01, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Clinical Outcomes After Idecabtagene Vicleucel In Older Patients With Multiple Myeloma: A Multicenter Real-World Experience, Nilesh M Kalariya, Michelle A T Hildebrandt, Doris K Hansen, Surbhi Sidana, Jack Khouri, Christopher J Ferreri, William N Doyle, Omar Castaneda-Puglianini, Ciara L Freeman, Vanna Hovanky, Hitomi Hosoya, Leyla O Shune, Krina K Patel

Faculty, Staff and Student Publications

The safety and efficacy of chimeric antigen receptor T-cell therapy is not well described in older patients, a population that has higher frailty and comorbidities. In this multicenter retrospective study, we evaluated clinical outcomes along with frailty and geriatric characteristics such as comorbidities, polypharmacy, falls, neuropathy, organ dysfunction, and performance status in younger (aged < 65 years) vs older (aged ≥65 years) patients who received commercial idecabtagene vicleucel (ide-cel). A total of 156 patients (n = 75, aged ≥65 years) were infused with ide-cel by data cutoff. In older patients (median age: 69 years; range, 65-83; 66.7% frail; 77.3% did not meet KarMMa eligibility criteria), with a median follow-up duration of 14.2 months, best overall response rate (ORR) was 86.7%, which was comparable with pivotal KarMMa study results (ORR: 73%). Median progression-free survival and overall survival in older patients were 9.1 months and 26.5 months, respectively. Grade ≥3 cytokine-release syndrome and immune effector cell-associated neurotoxicity syndrome were observed in 1% and 4% of older patients, respectively. Compared with younger patients, the older patients had significantly higher prevalence of frailty, geriatric characteristics such as polypharmacy (≥5 drugs; 97%), ≥4 comorbidities (69%), and organ dysfunction (35%; P < .05). The safety and efficacy of ide-cel therapy were similar in younger and older patients. Frailty and geriatric characteristics such as polypharmacy, comorbidities, and organ dysfunction in older patients did not confer an inferior overall outcome.

Final Outcomes From A Phase 2 Trial Of Posoleucel In Allogeneic Hematopoietic Cell Transplant Recipients., Sanjeet S. Dadwal, Rajat Bansal, Michael W. Schuster, Jean A. Yared, Douglas Myers, Michelle Matzko, Sama Adnan, David Mcneel, Julie Ma, Sarah A. Gilmore, Spyridoula Vasileiou, Ann M. Leen, Joshua A. Hill, Jo-Anne H. Young

Manuscripts, Articles, Book Chapters and Other Papers

Allogeneic hematopoietic cell transplantation (allo-HCT) recipients are susceptible to viral infections. We conducted a phase 2 trial evaluating the safety and rate of clinically significant infections (CSIs; viremia requiring treatment or end-organ disease) after infusion of posoleucel, a partially HLA-matched, allogeneic, off-the-shelf, multivirus-specific T-cell investigational product for preventing CSIs with adenovirus, BK virus, cytomegalovirus, Epstein-Barr virus, human herpesvirus-6, or JC virus. This open-label trial enrolled allo-HCT recipients at high risk based on receiving grafts from umbilical cord blood, haploidentical, mismatched, or matched unrelated donors; post-HCT lymphocytes of <180/mm3; or use of T-cell depletion. Posoleucel dosing was initiated within 15 to 49 days of allo-HCT and subsequently every 14 days for up to 7 doses. The primary end point was the number of CSIs due to the 6 target viruses by week 14. Of the 26 patients enrolled, only 3 (12%) had a CSI by week 14, each with a single target virus. In vivo expansion of functional virus-specific T cells detected via interferon-γ enzyme-linked immunosorbent spot assay was associated with viral control. Persistence of posoleucel-derived T-cell clones for up to 14 weeks after the last infusion was confirmed by T-cell-receptor deep sequencing. Five patients (19%) had acute graft-versus-host disease grade 2 to 4. No patient experienced cytokine release syndrome. All 6 deaths were due to relapse or disease progression. allo-HCT recipients at high risk who received posoleucel had low rates of CSIs from 6 targeted viruses. Repeat posoleucel dosing was generally safe and well tolerated and associated with functional immune reconstitution. This trial was registered at www.ClinicalTrials.gov as #NCT04693637.

Novel Thermoplastic Microvalves Based On An Elastomeric Cyclic Olefin Copolymer., Katie Childers, Ian M. Freed, Mateusz L. Hupert, Benjamin Shaw, Noah Larsen, Paul Herring, Jeanne H. Norton, Farhad Shiri, Judy Vun, Keith August, Małgorzata A. Witek, Steven A. Soper

Manuscripts, Articles, Book Chapters and Other Papers

Microfluidic systems combine multiple processing steps and components to perform complex assays in an autonomous fashion. To enable the integration of several bio-analytical processing steps into a single system, valving is used as a component that directs fluids and controls introduction of sample and reagents. While elastomer polydimethylsiloxane has been the material of choice for valving, it does not scale well to accommodate disposable integrated systems where inexpensive and fast production is needed. As an alternative to polydimethylsiloxane, we introduce a membrane made of thermoplastic elastomeric cyclic olefin copolymer (eCOC), that displays unique attributes for the fabrication of reliable valving. …

Calcium Modulates The Tethering Of Bcor-Prc11 Enzymatic Core To Kdm2b Via Liquid-Liquid Phase Separation, Rui Chen, Feng Shen, Yulong Zhang, Mingze Sun, Yan Dong, Yue Yin, Chen Su, Chao Peng, Jinsong Liu, Jinxin Xu

Faculty, Staff and Student Publications

Recruitment of non-canonical BCOR-PRC1.1 to non-methylated CpG islands via KDM2B plays a fundamental role in transcription control during developmental processes and cancer progression. However, the mechanism is still largely unknown on how this recruitment is regulated. Here, we unveiled the importance of the Poly-D/E regions within the linker of BCOR for its binding to KDM2B. Interestingly, we also demonstrated that these negatively charged Poly-D/E regions on BCOR play autoinhibitory roles in liquid-liquid phase separation (LLPS) of BCORANK-linker-PUFD/PCGF1RAWUL. Through neutralizing negative charges of these Poly-D/E regions, Ca2+ not only weakens the interaction between BCOR/PCGF1 and KDM2B, but also promotes co-condensation of …

Transcriptomic And Proteomic Differences In Btk-Wt And Btk-Mutated Cll And Their Changes During Therapy With Pirtobrutinib, Burcu Aslan, Ganiraju Manyam, Lakesla R Iles, Shady I Tantawy, Sai Prasad Desikan, William G Wierda, Varsha Gandhi

Faculty, Staff and Student Publications

Covalent Bruton tyrosine kinase inhibitors (cBTKis), which bind to the BTK C481 residue, are now primary therapeutics for chronic lymphocytic leukemia (CLL). Alterations at C481, primarily C481S, prevent cBTKi binding and lead to the emergence of resistant clones. Pirtobrutinib is a noncovalent BTKi that binds to both wild-type (WT) and C481S-mutated BTK and has shown efficacy in BTK-WT and -mutated CLL patient groups. To compare baseline clinical, transcriptomic, and proteomic characteristics and their changes during treatment in these 2 groups, we used 67 longitudinal peripheral blood samples obtained during the first 3 cycles of treatment with pirtobrutinib from 18 patients …

Targeting Prmt3 Impairs Methylation And Oligomerization Of Hsp60 To Boost Anti-Tumor Immunity By Activating Cgas/Sting Signaling, Yunxing Shi, Zongfeng Wu, Shaoru Liu, Dinglan Zuo, Yi Niu, Yuxiong Qiu, Liang Qiao, Wei He, Jiliang Qiu, Yunfei Yuan, Guocan Wang, Binkui Li

Faculty, Staff and Student Publications

Immune checkpoint blockade (ICB) has emerged as a promising therapeutic option for hepatocellular carcinoma (HCC), but resistance to ICB occurs and patient responses vary. Here, we uncover protein arginine methyltransferase 3 (PRMT3) as a driver for immunotherapy resistance in HCC. We show that PRMT3 expression is induced by ICB-activated T cells via an interferon-gamma (IFNγ)-STAT1 signaling pathway, and higher PRMT3 expression levels correlate with reduced numbers of tumor-infiltrating CD8+ T cells and poorer response to ICB. Genetic depletion or pharmacological inhibition of PRMT3 elicits an influx of T cells into tumors and reduces tumor size in HCC mouse models. Mechanistically, …

Cubic Spherical Neutrosophic Sets For Advanced Decision-Making, S Gomathi, M. Karpagadevi, S. Krishnaprakash, A. Revathy, Said Broumi

Neutrosophic Sets and Systems

In the context of aggregation operators and multiple criteria decision-making, this article presents the idea of cubic spherical neutrosophic sets. The notion of neutrosophic informations are transform into a geometric sphere by determining its center and radius. This advanced geometrical representation extends traditional neutrosophic informations. This study defines and discusses weighted additive and weighted geometric aggregation operators tailored to cubic spherical neutrosophic sets that are vital for handling complex and uncertain information. Practical example, such as evaluating fertilizer brands for coconut farming, illustrate their application in decision-making contexts. By integrating cubic spherical neutrosophic sets into multiple criteria decision-making frameworks, decision …

A Neutrosophic Approach For Breast Mass Detection In Digital Mammogram Images, Sofia Jennifer J, Kalaivani C

Neutrosophic Sets and Systems

Breast cancer is the most common type of cancer that affect women and yet there is no substantive cure. On early diagnosis of breast lesions with this size using mammogram would help the affected tumor patients have a good survival rate. Detecting cancer cells is a challenging task and hence we propose a single valued neutrosophic approach for segmenting breast tumor lesions in mammogram images. In this neutrosophic approach, the intensity values are represented as truth, indeterminacy and falsity membership in where the indeterminacy are noise, and the breast regions are the true and falsity values. The computations of these …

Enhanced Neutrosophic Set And Machine Learning Approach For Breast Cancer Prediction, Ashika T, Hannah Grace, Nivetha Martin, Florentin Smarandache

Neutrosophic Sets and Systems

Breast cancer is the most prevalent type of cancer that affects women worldwide and poses a serious risk to female mortality. In order to lower death rates and enhance treatment results, early detection is critical. Neutrosophic Set Theory (NST) and machine learning (ML) approaches are integrated in this study to provide a novel hybrid methodology (NS-ML) that improves breast cancer diagnosis. Using the Wisconsin Diagnostic Breast Cancer (WDBC) dataset, the research transforms these data into Neutrosophic (N) representations to effectively capture uncertainties. When trained on the N-dataset instead of traditional datasets, ML algorithms such as Decision Tree (DT), Random Forest …

Improved Method Of Interval Valued Neutrosophic Matrix Composition And Its Application In Medical Diagnosis, S. Sathiya, A. Puspalatha

Neutrosophic Sets and Systems

Neutrosophic sets are an important branch of topology that addresses issues with inconsistent, indeterminate, and uncertain situations in everyday life. Interval valued neutrosophic sets, known as subclasses of neutrosophic sets, have been specifically designed to address problems with a set of numbers in the real unit of interval rather than just a single number. Interval valued neutrosophic(IVN) matrix plays an influential role in decision making problems with indeterminant and inconsistent information. The objective of the paper is to discuss the concepts and operations of IVN matrix theory and propose a newly concept of an improved method of IVN matrix composition …

Neutrosophic Analysis On Internalization Of Higher Education In Indian Perspective, Nivetha Martin, Said Broumi, N. Ramila Gandhi, P. Pandiammal

Neutrosophic Sets and Systems

The developing nations of the Asian continent, especially India, are trying to elevate the educational standards by inaugurating the portals of international institutional linkages. Collaboration with foreign universities provides opportunities for the aspiring students to confer degrees from world premier institutions by stationing in their host nation. At the same time, the consequential impacts of the institutional linkages beyond the contours of countries need special attention to investigate on the dimensions of social, economic and culture. This chapter aims to make an intensive study on the challenges and impacts of institutional linkages between Institutions belonging to developing and developed nations. …