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Clinical-Transcriptional Prioritization Of The Circulating Proteome In Human Heart Failure, Andrew S Perry, Junedh Amrute, Kory J Lavine, Et Al.

2020-Current year OA Pubs

Given expanding studies in epidemiology and disease-oriented human studies offering hundreds of associations between the human "ome" and disease, prioritizing molecules relevant to disease mechanisms among this growing breadth is important. Here, we link the circulating proteome to human heart failure (HF) propensity (via echocardiographic phenotyping and clinical outcomes) across the lifespan, demonstrating key pathways of fibrosis, inflammation, metabolism, and hypertrophy. We observe a broad array of genes encoding proteins linked to HF phenotypes and outcomes in clinical populations dynamically expressed at a transcriptional level in human myocardium during HF and cardiac recovery (several in a cell-specific fashion). Many identified …

Footprint Tools Tiptoeing Towards Nitrogen Sustainability, James N. Galloway, Elizabeth A. Castner, Elizabeth S M Dukes, Jessica Fox, Allison M. Leach

Faculty Publications

As we face multiple environmental crises (e.g. climate change, nutrient pollution, freshwater scarcity), there is often a disconnect between an entity’s activities and the pollution resulting from that activity. Footprint tools help address this disconnect. They are effective in educating people, institutions and communities on how their resource use results in environmental pollution and what we can do to moderate that pollution. These tools connect an entity’s activities with the associated pollution. Footprint tools are also constantly evolving. As we better understand how to best estimate emissions—especially from sources further removed like those from the supply chain—the guidance and methods …

Footprint Tools Tiptoeing Towards Nitrogen Sustainability, James N. Galloway, Elizabeth A. Castner, Elizabeth S M Dukes, Jessica Fox, Allison M. Leach

Faculty Publications

As we face multiple environmental crises (e.g. climate change, nutrient pollution, freshwater scarcity), there is often a disconnect between an entity’s activities and the pollution resulting from that activity. Footprint tools help address this disconnect. They are effective in educating people, institutions and communities on how their resource use results in environmental pollution and what we can do to moderate that pollution. These tools connect an entity’s activities with the associated pollution. Footprint tools are also constantly evolving. As we better understand how to best estimate emissions—especially from sources further removed like those from the supply chain—the guidance and methods …

Flowing Forward: Impacting Health In Tanzania Through Clean Water And Sanitation, Krista A. White, Diane K. Daddario, Lisa K. Morris, Blaise B. Nieve, Sandra Rye, Anna Taber

Global Advocacy

Background: Approximately 70% of the Tanzanian population lives in rural areas, and nearly 50% lack access to clean water.1,2 The lack of clean water impacts health, education, time management, and food security.2,3 The task of carrying water typically falls to women and girls. Time spent gathering water takes girls away from school, thus diminishing their access to education and increasing gender inequality.3 Aims: Implementation of the global advocacy action plan would: (1) provide access to clean water within a 10-minute walk from home; (2) ensure young girls have access to education without barriers to gathering water; and (3) improve health …

2024 September 17, Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes No. 2 September 17, 2024

Impact Of An Online Decision Support Tool For Ductal Carcinoma In Situ (Dcis) Using A Pre-Post Design (Aft-25), Elissa Ozanne, Kellyn Maves, Angela Tramontano, Thomas Lynch, Alastair Thompson, Ann Partridge, Elizabeth Frank, Deborah Collyar, Desiree Basila, Donna Pinto, Terry Hyslop, Marc Ryser, Shoshana Rosenberg, E. Shelley Hwang, Rinaa Punglia

Department of Pharmacology and Experimental Therapeutics Faculty Papers

BACKGROUND: The heterogeneous biology of ductal carcinoma in situ (DCIS), as well as the variable outcomes, in the setting of numerous treatment options have led to prognostic uncertainty. Consequently, making treatment decisions is challenging and necessitates involved communication between patient and provider about the risks and benefits. We developed and investigated an interactive decision support tool (DST) designed to improve communication of treatment options and related long-term risks for individuals diagnosed with DCIS.

FINDINGS: The DST was developed for use by individuals aged > 40 years with DCIS and is based on a disease simulation model that integrates empirical data and …

Teacher Challenges For Implementing Response To Intervention Using Distance Learning, Krystiana Bonheur

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic in March 2020 resulted in widespread school closures, leading to a rapid transition from traditional face-to-face instruction to distance learning. Educators who used this traditionally face-to-face multi-tiered instructional framework to provide services to students with disabilities faced obstacles with implementation due to the transition to distance learning. This qualitative, phenomenological approach study explored the challenges and strategies of implementing Response to Intervention during the COVID-19 epidemic. Using the theoretical framework of social learning theory and the situated cognition theory, this research explored the implementation of RTI during the COVID-19 school closures from the perspective of new and …

Employee Retention Plan For A Maryland Nonprofit Organization, Frant Kembou

Walden Dissertations and Doctoral Studies

Nonprofit organizations (NPOs) face many challenges impacting their program implementation and mission accomplishment. CTL is a NPO operating in Maryland. Like many other NPOs, CTL faces an employee retention problem that affects its ability to complete its social activities and benefit the communities it serves. The practice-focused research question of this study was focused on developing strategies and methods to improve employee retention at CTL. This professional administrative study involved exploring strategies and methods to improve employee retention at CTL using a general qualitative method. Herzberg’s two-factor theory was the conceptual framework for the study. Data were collected using semi-structured …

Development Of Message Passing-Based Graph Convolutional Networks For Classifying Cancer Pathology Reports, Hong Jun Yoon, Hilda B. Klasky, Andrew E Blanchard, J. Blair Christian, Eric B Durbin, Xiao Cheng Wu, Antoinette Stroup, Jennifer Doherty, Linda Coyle, Lynne Penberthy, Georgia D Tourassi

School of Public Health Faculty Publications

Background: Applying graph convolutional networks (GCN) to the classification of free-form natural language texts leveraged by graph-of-words features (TextGCN) was studied and confirmed to be an effective means of describing complex natural language texts. However, the text classification models based on the TextGCN possess weaknesses in terms of memory consumption and model dissemination and distribution. In this paper, we present a fast message passing network (FastMPN), implementing a GCN with message passing architecture that provides versatility and flexibility by allowing trainable node embedding and edge weights, helping the GCN model find the better solution. We applied the FastMPN model to …

What About Us? A Quantitative Analysis Of Microaggressions In Community Colleges, Marcelo Angulo

Seton Hall University Dissertations and Theses (ETDs)

Microaggressions have been studied in higher-education institutions, professional work environments, and ordinary life. However, most research studies on microaggressions in higher education focus on the experiences of college students at four-year institutions, exposing a gap in the literature on microaggressions in two-year community colleges. Research has shown that community college students’ collegiate experiences differ from those of students at more “traditional” college settings, based on factors such as cost of attendance, flexibility, and campus life. The increasing diversity of student demographics in community colleges suggests a greater likelihood for microaggressions to arise within these institutions. Thus, a quantitative approach was …

Economic Development, Undernutrition And Diabetes, Kaivan Munshi, Swapnil Singh, Nancy Luke, Anu Mary Oommen

Cowles Foundation Discussion Papers

This research connects two seemingly unrelated facts that have recently been documented in developing countries, with important consequences for global health: (i) the weak association between nutritional status and income, and (ii) the elevated risk of diabetes among normalweight individuals. The model that we develop to reconcile these facts is based on a set point for body size that is adapted to (low) pre-modern food supply, but subsequently fails to adjust to rapid economic change. During the process of development, some individuals thus remain at their low-BMI set point, despite the increase in their income (food consumption), while others who …

Pair Of Alums Fighting To Keep Kids Safe Online, Keith Testa

UNH Today Archive

No abstract provided.

Heat-Related Emergencies In The Older Adult, Michelle I. Suh

Journal of Geriatric Emergency Medicine

n/a

Association Between Non-Injection Drug Use And Hepatitis C Infection Among Hiv-Negative Men Who Have Sex With Men, Jing Zhao, Charles Green, Christine Markham, Kayo Fujimoto, Alan G Nyitray, Lu-Yu Hwang

Faculty, Staff and Student Publications

Background: Prior research predominantly examined the association between HIV-positive men who have sex with men (MSM) or those using injection drugs and hepatitis C virus (HCV) infection. However, limited attention has been given to understanding the association among HIV-negative MSM who do not inject drugs. This gap leaves apportion of the population unexamined, potentially overlooking important factor that may contribute to the transmission and prevalence of HCV. This study aims to investigate the relationship between non-injection drug use and HCV infection in this population.

Methods: In this cross-sectional study, we analyzed data on 118 MSM who reported use of non-injection …

The Lived Experiences Of Developing A Strong Black Woman Schema For Resilient Black Women With Adverse Childhood Experiences, Lindsey Erin Dickson

Walden Dissertations and Doctoral Studies

Adverse childhood experiences (ACEs) encompass a spectrum of adversities that can impact mental and physical health in adulthood, particularly in Black women. Although there was a substantial body of research on the consequences of ACEs and the coping strategies employed by Black women, there remained a gap in understanding the nuanced experiences of those who develop a Strong Black Woman (SBW) schema. The purpose of this qualitative phenomenological study was to explore the lived experiences of developing an SBW schema among resilient Black women who had faced ACEs. The research was grounded in resilience theory and SBW schema and provided …

The Link September 17, 2024, Access To Justice Institute

The Link Newsletter

No abstract provided.

Gut Phageome In Mexican Americans: A Population At High Risk For Metabolic Dysfunction-Associated Steatotic Liver Disease And Diabetes, Suet-Ying Kwan, Caroline M Sabotta, Lorenzo R Cruz, Matthew C Wong, Nadim J Ajami, Joseph B Mccormick, Susan P Fisher-Hoch, Laura Beretta

Faculty, Staff and Student Publications

Mexican Americans are disproportionally affected by metabolic dysfunction-associated steatotic liver disease (MASLD), which often co-occurs with diabetes. Despite extensive evidence on the causative role of the gut microbiome in MASLD, studies determining the involvement of the gut phageome are scarce. In this cross-sectional study, we characterized the gut phageome in Mexican Americans of South Texas by stool shotgun metagenomic sequencing of 340 subjects, concurrently screened for liver steatosis by transient elastography. Inter-individual variations in the phageome were associated with gender, country of birth, diabetes, and liver steatosis. The phage signatures for diabetes and liver steatosis were subsequently determined. Enrichment of …

Loss Of P53 And Smad4 Induces Adenosquamous Subtype Pancreatic Cancer In The Absence Of An Oncogenic Kras Mutation, Daowei Yang, Xinlei Sun, Rohan Moniruzzaman, Hua Wang, Citu Citu, Zhongming Zhao, Ignacio I Wistuba, Huamin Wang, Anirban Maitra, Yang Chen

Faculty, Staff and Student Publications

Pancreatic cancer is associated with an oncogenic KRAS mutation in approximately 90% of cases. However, a non-negligible proportion of pancreatic cancer cases harbor wild-type KRAS (KRAS-WT). This study establishes genetically engineered mouse models that develop spontaneous pancreatic cancer in the context of KRAS-WT. The Trp53

Detecting Altered Hepatic Lipid Oxidation By Mri In An Animal Model Of Masld, Marc Mcleod, Mario C Chang, Anna Rushin, Mukundan Ragavan, Rohit Mahar, Gaurav Sharma, Arshee Badar, Anthony Giacalone, Max E Glanz, Vinay R Malut, Dalton Graham, Nishanth E Sunny, James A Bankson, Kenneth Cusi, Matthew E Merritt

Faculty, Staff and Student Publications

Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing annually and affects over a third of US adults. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH), characterized by severe hepatocyte injury, inflammation, and eventual advanced fibrosis or cirrhosis. MASH is predicted to become the primary cause of liver transplant by 2030. Although the etiology of MASLD/MASH is incompletely understood, dysregulated fatty acid oxidation is implicated in disease pathogenesis. Here, we develop a method for estimating hepatic β-oxidation from the metabolism of [D

Body, Ritual, And Place: Advancing Their Chronotopic Interrelationship In Design Praxis And Pedagogy Through An Exploration Of Juxtaposed Surfaces, Threshold Sites Of Dialogic Encounter, And Collage, Robert Brown, Zoe Latham

School of Art, Design and Architecture

Echoing philosopher Mikhail Bakhtin’s chronotope, an ‘intrinsic connectedness of temporal and spatial relationships,’ our work explores the interrelation of the body, ritual, and place as a chrontopic site of design and pedagogy. This exploration reaffirms architecture’s grounding in people, their inhabitation of place, and spatial form, an interrelatedness too often underexamined withinarchitectural education. First positioning ritual thematically, our discussion addresses three interrelated issues: the role of juxtaposed ritual surfaces in activating the body, ritual and place; the potential of ritual surfaces as threshold sites of dialogic encounter; and collage as a medium to investigate and communicate the interrelationship of body, …

Reflecting On Reflexivity In Realist Evaluation: A Call To Action, John Downey, Sarah Rybczynska-Bunt

School of Nursing and Midwifery

Realist evaluation is increasingly utilised across disciplines due to the value of identifying which mechanisms may explain how, and why, particular outcomes are generated in specific contexts. In theory, realist evaluation provides a tangible way to analyse the inherent complexity in many pressing societal challenges. Realist evaluation encourages a mixed methods approach and choosing a suite of methods that are most relevant within a specific project. Yet, navigating a plurality of methods with abstract philosophical concepts brings operational challenges such that, further methodological guidance is needed. Research processes can be opaque and although the relativist epistemology in realist evaluation is …

Design Considerations For Self-Management Technologies For People Living With Dementia And Informal Carers – Perspectives Of Healthcare Professionals And Charity Workers, Dympna O'Sullivan

Conference papers

Dementia is a neurodegenerative disorder that leads to decline in memory, language, reasoning, and the ability to perform daily activities. It is linked to poorer quality of life for the person with dementia and their informal (unpaid) carers. While early intervention and access to adequate care are critical in slowing dementia's progression and better managing associated symptoms, dementia is frequently only diagnosed at an advanced stage and care is often fragmented. To better understand how to meet the complex needs of persons living with dementia and their informal carers, 10 healthcare professionals and 10 charity workers from relevant community and …

Design Considerations For Self-Management Technologies For People Living With Dementia And Informal Carers - Perspectives Of Healthcare Professionals And Charity Workers, Dympna O'Sullivan, Julie Doyle, Orla Moran, Michael Wilson, Siobhan Oneill, Jonathan Turner, Suzanne Smith

Conference papers

Dementia is a neurodegenerative disorder that leads to decline in memory, language, reasoning, and the ability to perform daily activities. It is linked to poorer quality of life for the person with dementia and their informal (unpaid) carers. While early intervention and access to adequate care are critical in slowing dementia's progression and better managing associated symptoms, dementia is frequently only diagnosed at an advanced stage and care is often fragmented. To better understand how to meet the complex needs of persons living with dementia and their informal carers, 10 healthcare professionals and 10 charity workers from relevant community and …

The George-Anne, Georgia Southern University

The George-Anne

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Advancing Consensual Non-Monogamy In Psychological Research, Practice, And Policy: A Guide For Psychologists, Amy C. Moors, Michelle Denise Vaughan, Sharon M. Flicker, Kaiponanea T. Matsumura, Heath A. Schechinger

Psychology Faculty Articles and Research

In this article, we present a brief overview of the topic of consensual non-monogamy (CNM) as a scientific inquiry, including reviews related to stigma, relationship functioning, and health and well-being. Next, we discuss how psychologists can be more responsive to people who engage in CNM, by (1) conducting research that is inclusive of CNM, including challenging mononormativity in theory and measurement; (2) training clinicians to be more knowledgeable about CNM, including expanding diversity requirements and evidence-based clinical practice; (3) working in advocacy to help shape law and policy, including future directions for research to inform marital/family and antidiscrimination law. Our …

Effects Of Sotagliflozin On Health Status In Patients With Worsening Heart Failure: Results From Soloist-Whf, Ankeet S Bhatt, Deepak L Bhatt, Ph Gabriel Steg, Michael Szarek, Christopher P Cannon, Lawrence A Leiter, Darren K Mcguire, Julia B Lewis, Matthew C Riddle, Adriaan A Voors, Marco Metra, Lars H Lund, Jeffrey M Testani, Christopher S Wilcox, Michael Davies, Bertram Pitt, Mikhail N Kosiborod

Faculty, Staff and Student Publications

Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors improve health status in heart failure (HF) across the left ejection fraction ejection spectrum. However, the effects of SGLT1 and SGLT2 inhibition on health status are unknown.

Objectives: These prespecified analyses of the SOLOIST-WHF (Effect of Sotagliflozin on Cardiovascular Events in Patients with Type 2 Diabetes Post Worsening Heart Failure) trial examined the effects of sotagliflozin vs placebo on HF-related health status.

Methods: SOLOIST-WHF randomized patients hospitalized or recently discharged after a worsening HF episode to receive sotagliflozin or placebo. The primary endpoint was total number of HF hospitalizations, urgent HF visits, and cardiovascular …

Quality Of Life Changes In Middle-Aged Men After An Acute Stroke Or Traumatic Brain Injury, Angela J. Garner

Walden Dissertations and Doctoral Studies

Surviving a stroke or traumatic brain injury (TBI) can bring about life changes and negatively impact future quality of life. Studies that focus specifically on men who suffer these injuries is limited. The purpose of this qualitative study was to explore quality of life of middle-aged men who suffered an acute stroke or TBI. The transactional model of stress and coping and the social identity theory were theoretical frameworks. Common themes were established during data analysis. Three research questions explored the narratives of masculine identity and quality of life in middle-aged men who experience a stroke or TBI. How having …

The Lived Experiences Of African American Women Regarding Their Prenatal Care, Alison R. Edinboro

Walden Dissertations and Doctoral Studies

The practical manifestation of health inequality can cause a severe societal problem for the African American community. African American women are at risk of their lives and often live in abject poverty. The purpose of this qualitative hermeneutic phenomenological design study was to understand the personal viewpoint and perspective of the lived experiences of African American women regarding their prenatal care experiences. The research question will address perceptions of African American women regarding their prenatal care experience in Southern New York." The qualitative dissertation employs a researcher-designed interview protocol based on Kleinman’s explanatory model of illness. After conducting semi-structured interviews …

Impact Of The Covid-19 Pandemic On The Elderly, Jessica Odikpo

Walden Dissertations and Doctoral Studies

No abstract provided.

Mechanisms Of Uropathogenic E. Coli Reservoir Formation In The Gastrointestinal Tract, Philippe Nimma Azimzadeh

Arts & Sciences Graduate Student Theses and Dissertations

Urinary tract infections (UTI) are an extremely common affliction affecting 150 million people worldwide each year. UTIs are a leading cause of antibiotic therapy among otherwise healthy adult women, accounting for 15% of all outpatient antibiotic prescriptions. Uropathogenic Escherichia coli (UPEC) cause over 80% of community-acquired UTIs. Even when infection is cleared from the urine by clinical antibiotic regimens, 27% of women will experience recurrent UTI (rUTI) within months. Greater than 60% of rUTIs are caused by the same strain of E. coli that caused the initial infection, suggesting that one or more host-associated reservoirs of UPEC can re-inoculate the …