Digital Commons Network^™

Predictors Of Transition From Child And Adolescent Bipolar Not Otherwise Specified To Bipolar I Disorder, A Longitudinal 3.9-Year Study., María Ribeiro-Fernández, Azucena Díez-Suárez, Kiki D Chang, Cesar A Soutullo

Faculty, Staff and Student Publications

Background: Children and adolescents with subthreshold manic symptoms not meeting full DSM criteria for bipolar I or II disorder (BP-I or BP-II) are classified as unspecified bipolar disorder (formerly bipolar not otherwise specified: BP-NOS). Factors associated with transition from BP-II or NOS to BP-I may predict the progression of the disorder. Our objective is to analyze factors associated with transition to BP-I in a Spanish sample of youth with BP-NOS or BP-II.

Methods: We included all youth diagnosed with BP before 18 years of age presenting to our clinic (October 1999-December 2014). We assessed clinical factors that may predict transition …

Open Access For Student Researchers In Stem, Denise Brush

Library Workshops

This workshop is for graduate and undergraduate students involved in science and engineering research on the Glassboro campus. It is critical for students to understand the pros and cons of making their research results available worldwide on Rowan University's institutional repository (Rowan Digital Works). While Open Access has many benefits, there are also potential issues around journal publication and commercialization that must be considered. Student researchers should understand the implications of making their research Open Access, to make an informed choice now and in their future research.

Successful Strategies Used By Information Technology Talent Acquisition Managers To Retain Niche Employees, Lucie Tuttle

Walden Dissertations and Doctoral Studies

Ineffective retention strategies for niche information technology (IT) employees can negatively impact business technological capabilities. Talent acquisition managers who struggle to retain niche IT employees beyond 2 years are at a high risk of business instability. Grounded in the job characteristics model, job characteristics theory, and expectancy theory, the purpose of this pragmatic qualitative inquiry was to explore strategies IT talent acquisition managers use to retain niche employees beyond 2 years. The participants were six IT talent acquisition managers who had effectively implemented strategies to retain niche employees beyond 2 years. Data were collected using semistructured interviews, public websites, and …

Cd103+ Cdc1 Dendritic Cell Vaccine Therapy For Osteosarcoma Lung Metastases, Yuanzheng Yang, Yifan Zhou, Jian Wang, You Zhou, Stephanie S Watowich, Eugenie S Kleinerman

Faculty, Staff and Student Publications

Background: We generated a CD103+DC vaccine using K7M3 OS cell lysates (cDCV) and investigated its ability to induce regression of primary tumors, established lung metastases, and a systemic immune response. Methods: A bilateral tumor model was used to assess cDCV therapy efficacy and systemic immunity induction. K7M3 cells were injected into mice bilaterally. Right-sided tumors received PBS (control) or cDCV. Left-sided tumors were untreated. Tumor growth was compared between the vaccine-treated and untreated tumor on the contralateral side and compared to the control group. The immune cell profiles of the tumors, and tumor-draining lymph nodes (TdLNs) and spleen were evaluated. …

Navigating The Maze: Women Experiences Transitioning From Faculty To High-Level Administration In Four-Year Postsecondary Institutions In The United States, Jonathan Miles Hubbell

Theses and Dissertations

This dissertation explores the experiences of women transitioning from faculty roles to high-level administrative positions within four-year postsecondary institutions in the United States. Utilizing a phenomenological approach, this study investigates the strategies, challenges, and successes of nine women who have navigated this career progression, highlighting the systemic barriers they faced and the resilience they developed along the way. Through the lens of resiliency theory and intersectionality, the research examines how women balance personal and professional obligations, overcome institutional barriers, and utilize mentorship networks to support their advancement. From the in-depth interviews, four themes emerged: (a) adaptability, (b) resilience, (c) mentoring, …

Knowledge And Confidence Of Obstetrics And Gynecology Residents In The Evaluation And Management Of Heavy Menstrual Bleeding Due To Inherited Bleeding Disorders., Patricia S. Huguelet, Irmel A. Ayala, Laurel Beaty, Christina Bemrich-Stolz, Claudia Borzutzky, Tazim Dowlut-Mcelroy, Sweta Gupta, Kendra Hutchens, Corinna L. Schultz, Lakshmi Srivaths, Maria C. Velez, Neeraja Swaminathan

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Heavy menstrual bleeding (HMB) is common, and 20-30% of patients presenting with HMB are diagnosed with an inherited bleeding disorder (IBD). Despite the frequent association of HMB with bleeding disorders, specific learning objectives on this topic are lacking for Obstetrics and Gynecology (OBGYN) residents.

OBJECTIVE: We sought to determine the exposure of OBGYN residents to didactics, clinical training, and confidence in evaluation and management of patients with HMB due to IBDs.

METHODS: Prospective survey of OBGYN residents through email solicitation. Residents were invited to complete an anonymous 26-item survey, querying residents' confidence in evaluation and management of HMB in …

Power, Voice, And Agency: Empowering Adolescent Girls And Young Women Through Multiple Interventions For Evidence-Informed Contraceptive Decisions, Evalin Karijo, Karen Austrian, Miriam Temin, Mame Soukeye Mbaye

Adolescents and Young People

This blog is part of a series in partnership with Population Council, Reproductive Health Supplies Coalition (RHSC), and Population Services International (PSI), to recognize World Contraception Day 2024. It was originally published on the Council's website.

Body, Loss, Memory And Healing: Three Emerging Emirati Women Artists, Ioannis Galanopoulos Papavasileiou, Aysha Al Dhaheri, Mariam Al Mansoori, Sara Alqardaeai

All Works

The UAE is rapidly transforming into a global cultural hub with the establishment of prominent institutions such as the Sheikh Zayed National Museum, the Louvre, and the Guggenheim in Abu Dhabi. Sharjah hosts the Exposure International Photo Festival and an art biennale, with a historic district featuring numerous museums and galleries. Dubai is home to Art Dubai, a leading international art fair in the Middle East, and recently hosted the World Expo and COP28. These developments not only highlight the UAE as a dynamic business hub driven by the petroleum and energy sectors but also position it as an attractive …

Mental Health During The Covid-19 Pandemic In Trinidad: An Analysis Of Depression, Anxiety, And Stress Among Essential Workers, Bernadette Marson, Gerard A. Hutchinson

Journal of Social, Behavioral, and Health Sciences

Research shows that some essential workers, such as healthcare workers, social workers, and first responders (including police officers, paramedics, and firefighters), are at greater risk for developing both short- and long-term mental health problems (Berger et al., 2012; Canady, 2022; Grey et al., 2020; Haugen et al., 2012; Mohamed et al., 2022; Petrie et al., 2018). The most prevalent of these include anxiety, depression, and stress, as well as other social and cognitive problems—with stress causing harmful effects on mental health and potentially resulting in anxiety and depression, which may then disrupt an individual’s social relationships, family life, and work. …

A Review Of Studies On Hiv Pre-Exposure Prophylaxis In Community Pharmacies In States With Restrictive Pharmacist Prescription Authority In The United States, Hongmei Wang, Dominique Guinn, Xavier Roshitha Ramisetty, Thomas P Giordano, Ivy O Poon

Faculty, Staff and Students Publications

Community pharmacies have unparalleled potential to increase access to pre-exposure prophylaxis medications (PrEP) for HIV prevention; however, only 17 out of 50 states in the United States have statewide authority for pharmacists to provide PrEP at community pharmacies. Few studies have reported on how pharmacists overcome the legislative barrier and provide PrEP services in restrictive pharmacy prescription states. The objective of this article is to identify the existing primary literature describing pharmacist PrEP services in the community in states with restrictive prescription authority. Methods: A systemic literature review was conducted to identify the primary literature that involved community pharmacy service …

Olfactory Deficit And Gastrointestinal Dysfunction Precede Motor Abnormalities In Alpha-Synuclein G51d Knock-In Mice, Youngdoo Kim, Joseph Mcinnes, Jiyoen Kim, Yan Hong Wei Liang, Surabi Veeraragavan, Alexandra Rae Garza, Benjamin David Webst Belfort, Benjamin Arenkiel, Rodney Samaco, Huda Yahya Zoghbi

Faculty, Staff and Students Publications

Many Parkinson’s disease (PD) models overexpress α-Synuclein using heterologous promoters, which is adequate to demonstrate that excessive α-Synuclein is toxic but not ideal for learning the precise ontogeny of the disease pathogenesis, specifically where the disease starts and how it progresses. To answer these questions, it is beneficial to generate a mouse model expressing a disease-causing mutation under the endogenous promoter. Here, we generated three Snca knock-in mice. Among them, homozygous Snca^G51D mice develop motor deficits by 9 mo of age. These mice exhibit olfactory and gastrointestinal abnormalities by 6 mo. They lose dopaminergic neurons and have reduced dopamine …

Motion 2024.9.24 Motion To Appoint Faculty Appeals Committee And Faculty Representatives To University Committees, Faculty Senate, Committee On Committees, Xinhua Yu

Faculty Senate Motions

A Motion to Appoint Faculty Appeals Committee and Faculty Representatives to University Committees

Qualitative Investigation Of School Experiences In Children With Osteogenesis Imperfecta, Julia M Morales, Andrew D Wiese, Whitney S Shepherd, Gianna M Colombo, Selena Guo, Justin Qian, W Conor Rork, Hannah Cho, Kristin M Kostick-Quenet, Dianne Nguyen, Erin M Carter, Michelle L Fynan, Members Of The Bbdc, Chaya N Murali, Marie-Eve Robinson, Sophie C Schneider, Brendan Lee, V Reid Sutton, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

Osteogenesis imperfecta (OI) is a rare genetic chronic condition leading to fragile bones and frequent bone fractures with wide-reaching health implications. Current literature suggests that children with chronic diseases face unique challenges at school, yet research regarding educational concerns among those with OI is limited. The present study involved qualitative analysis of semi-structured interviews with 10 children with OI and 12 caregivers of a child with OI. Children and caregivers participated in the interviews individually; they were not dyads of participants. Half of the caregivers who participated had OI themselves. The interviews were coded, and six themes were identified: (1) …

Conformational Ensembles In Klebsiella Pneumoniae Fimh Impact Uropathogenesis, Edward D B Lopatto, Jerome S Pinkner, Denise A Sanick, Robert F Potter, Lily X Liu, Jesús Bazán Villicaña, Kevin O Tamadonfar, Yijun Ye, Maxwell I Zimmerman, Nathaniel C Gualberto, Karen W Dodson, James W Janetka, David A Hunstad, Scott J Hultgren

2020-Current year OA Pubs

No abstract provided.

Evaluating The Impact Of A Year-Long External Mentorship Pilot Program In Classical Hematology, Zoya Qureshy, Pooja Nair, Sara K Vesely, Allison A King, Alfred I Lee, Nathan T Connell, Annette Von Drygalski, Ida Wong-Sefidan, Martina C Murphy, Ronak H Mistry, Rebecca L Zon, Erin G Reid, Josel Fritz, Soo J Park

2020-Current year OA Pubs

Effective mentorship is a pivotal factor in shaping the career trajectory of trainees interested in classical hematology (CH), which is of critical importance due to the anticipated decline in the CH workforce. However, there is a lack of mentorship opportunities within CH compared with medical oncology. To address this need, a year-long external mentorship program was implemented through the American Society of Hematology Medical Educators Institute. Thirty-five hematology/oncology fellows interested in CH and 34 academically productive faculty mentors from different institutions across North America were paired in a meticulous process that considered individual interests, experiences, and background. Pairs were expected …

Intracranial Aneurysms In Sickle Cell Disease Are Associated With Hemodynamic Stress And Anemia, Yan Wang, Jared S Garland, Slim Fellah, Martin N Reis, Matthew S Parsons, Kristin P Guilliams, Melanie E Fields, Amy E Mirro, Josiah B Lewis, Chunwei Ying, Rachel A Cohen, Monica L Hulbert, Allison A King, Yasheng Chen, Jin-Moo Lee, Hongyu An, Andria L Ford

2020-Current year OA Pubs

Although hemodynamic stress plays a key role in aneurysm formation outside of sickle cell disease (SCD), its role is understudied in patients with SCD. We hypothesized that tissue-based markers of hemodynamic stress are associated with aneurysm presence in a prospective SCD cohort. Children and adults with SCD, with and without aneurysms, underwent longitudinal brain magnetic resonance imaging/magnetic resonance angiography (MRA) to assess cerebral blood flow (CBF) and oxygen extraction fraction (OEF). Baseline characteristics were recorded. In the subgroup of adults, stepwise mixed-effect logistic regression examined clinical variables, CBF, and OEF as predictors of aneurysm presence. Cumulative rates of new aneurysm …

The Trim4 E3 Ubiquitin Ligase Degrades Tpl2 And Is Modulated By Oncogenic Kras, Sapana Bansod, Paarth B Dodhiawala, Yutong Geng, Ashenafi Bulle, Peng Liu, Lin Li, Reid Townsend, Patrick M Grierson, Jason M Held, Hema Adhikari, Kian-Huat Lim

2020-Current year OA Pubs

Loss-of-function mutations in the C terminus of TPL2 kinase promote oncogenesis by impeding its proteasomal degradation, leading to sustained protein expression. However, the degradation mechanism for TPL2 has remained elusive. Through proximity-dependent biotin identification (BioID), we uncovered tripartite motif-containing 4 (TRIM4) as the E3 ligase that binds and degrades TPL2 by polyubiquitination of lysines 415 and 439. The naturally occurring TPL2 mutants R442H and E188K exhibit impaired TRIM4 binding, enhancing their stability. We further discovered that TRIM4 itself is stabilized by another E3 ligase, TRIM21, which in turn is regulated by KRAS. Mutant KRAS recruits RNF185 to degrade TRIM21 and …

Spatiotemporal Relationships Between Neuronal, Metabolic, And Hemodynamic Signals In The Awake And Anesthetized Mouse Brain, Xiaodan Wang, Jonah A Padawer-Curry, Annie R Bice, Byungchan Kim, Zachary P Rosenthal, Jin-Moo Lee, Manu S Goyal, Shannon L Macauley, Adam Q Bauer

2020-Current year OA Pubs

Neurovascular coupling (NVC) and neurometabolic coupling (NMC) provide the basis for functional magnetic resonance imaging and positron emission tomography to map brain neurophysiology. While increases in neuronal activity are often accompanied by increases in blood oxygen delivery and oxidative metabolism, these observations are not the rule. This decoupling is important when interpreting brain network organization (e.g., resting-state functional connectivity [RSFC]) because it is unclear whether changes in NMC/NVC affect RSFC measures. We leverage wide-field optical imaging in Thy1-jRGECO1a mice to map cortical calcium activity in pyramidal neurons, flavoprotein autofluorescence (representing oxidative metabolism), and hemodynamic activity during wake and ketamine/xylazine anesthesia. …

Prevalence And Progression Of Albuminuria After Smoking Cessation: A Uk Biobank Cohort Study, Debasish Kar

Peninsula Medical School

No abstract provided.

Experiences Of Integrating Social Prescribing Link Workers Into Primary Care In England: Bolting On, Fitting In Or Belonging, Stephanie Tierney, Debra Westlake, Geoff Wong, Amadea Turk, Steven Markham, Jordan Gorenberg, Joanne Reeve, Caroline Mitchell, Kerryn Husk, Sabi Redwood, Catherine Pope, Beccy Baird, Kamal R. Mahtani

Peninsula Medical School

Background: Following the 2019 NHS Long-Term Plan, link workers (LWs) have been employedacross primary care in England to deliver social prescribing (SP).Aim: To understand and explain how the LW role is being implemented in primary care in England.Design and setting: Realist evaluation undertaken in England.Method: Focused ethnographies around seven LWs from different parts of England. As part of this,we interviewed 61 patients and 93 professionals from healthcare and the voluntary, community andsocial enterprise (VCSE) sector. We reinterviewed 41 patients, seven LWs and a LW manager 9-12months after their first interview.Results: We developed four concepts around how LWs are integrated (or …

Burden Of Diabetes Mellitus In The Medically Underserved Rio Grande Valley, John M. Gaddis, Elias Arellano, Kassandra Pulido, Tyler Torres, Dominic Chau-Zanetti, Natasha N. Quailes, Andres Suarez Parraga

School of Medicine Publications

Introduction

Diabetes mellitus (DM) encompasses metabolic disorders characterized by elevated blood sugar. This study aimed to evaluate the prevalence and associated metrics of DM in the Rio Grande Valley (RGV), a low-income and medically underserved region in the United States, and compare these metrics to the national averages from 2012 to 2022.

Methods

A retrospective cross-sectional analysis was conducted using publicly accessible data from the Centers for Medicare and Medicaid Services (CMS). Metrics analyzed included DM prevalence, average principal cost, rates of emergency department visits, hospitalizations, screenings, and prevalence of obesity. Data from the RGV counties were compared to national …

Neuroprotective Effects Of Magnesium: Implications For Neuroinflammation And Cognitive Decline, Veer Patel, Nuraly S. Akimbekov, William B. Grant, Carolyn Dean, Xiaoqian Fang, Mohammed S. Razzaque

School of Medicine Publications

Neurodegenerative diseases, which are characterized by progressive neuronal loss and cognitive decline, are a significant concern for the aging population. Neuroinflammation, a shared characteristic of these diseases, is implicated in their pathogenesis. This article briefly summarizes the role of magnesium, an essential mineral involved in numerous enzymatic reactions and critical for neuronal bioactivity, in the context of neuroinflammation and cognitive decline. The potential neuroprotective effects of magnesium, including the mechanisms of neuroprotection by magnesium through maintaining neuronal ion homeostasis, reducing inflammation, and preventing excitotoxicity, are also described. Additionally, we discuss the impact of inadequate magnesium on neuroinflammation and its potential …

Exploring The Identification Of Autoregression Model By General Least Deviation Method, Mostafa Abotaleb, Tatiana Makarovskikh, Ramadhan, Ali J

Al-Bahir

We are considering a novel method for analyzing time series data that relies on quasi-linear recurrence relations. Unlike neural networks, this approach allows for directly formulating high-quality quasi-linear difference equations that accurately represent the studied process. Techniques for determining the parameters of a single equation have been devised and validated. This work discusses and tests a technique for identifying the parameters of a quasi-linear recurrence equation. This approach is employed to tackle the issue of regression analysis including observable variables that are mutually dependent. It enables the utilization of the Generalized Least Deviations Method (GLDM). This model was utilized in …

Vol. 22, No. 12 - Whole No. 67, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 22, No. 1 - Whole No. 56, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Using Training Videos For Learning Clinical Skills Can Influence Perceptions On Expertise: Observations Through A Metacognitive Lens, Kennedy A. Forest, Sydney L. Bormann, Roy Mortinsen, Colin J. Greengrass

Aesculapius Journal (Health Sciences & Medicine)

Introduction

Video-based instruction is a valuable method for imparting clinical skill knowledge. The aim of this study is to investigate the broader impact of training videos beyond perceived performance measures. This study seeks to determine whether instructional video exposure can enhance knowledge of procedures in the cognitive domain and improve metacognitive monitoring of performance.

Methods

Third-year medical students created instructional videos demonstrating musculoskeletal examination skills as a supplement to in-person instruction for first-year medical students. Students completed an online survey before and after video exposure, assessing perceptions of preparedness, anxiety, confidence, and their understanding of expectations related to performing specific …

Inclusivity In The Classroom: Shared Experiences Of A Student-Faculty Partnership, Kelly Basile, Cynthia Brito

Teaching and Learning Together in Higher Education

No abstract provided.

Insisting On Inclusive Practices, Alison Cook-Sather

Teaching and Learning Together in Higher Education

No abstract provided.

Development Of Intensive Grassland Systems: From Science To Practice, D G. Mccall, G W. Sheath

IGC Proceedings (1977-2023)

Level of nnimal production from grassland is determined by the amount of pasture grown, pasture utilisation and animal conversion efficiency. The key components affecting production are pasture growth and animal conversion efficiency. These arc mainly influenced by environment, genetics and through inputs to maintain soil fertility or animal health. Systems development aims to link pasture growth and animal conversion through efficient strategies for pasture utilisation. The means of influencing pasture utilisation is through adjustments to animal feed demand, feed supply or grazing management. Stock policies that adjust the pattern and level of feed demand are of greatest significance in developing …

Secular Trends In Underweight, Overweight, And Physical Fitness Of Girls And Boys Aged 16–18 In Eastern Poland From 2006 To 2016–2021, Agnieszka Wasiluk, Jerzy Saczuk

Baltic Journal of Health and Physical Activity

Introduction: Significant changes in the nutrition and physical fitness of children and adolescents have been observed in many countries around the world. The purpose of this study is to determine the changes in the prevalence of underweight, normal BMI, and overweight, as well as in the physical fitness of girls and boys from eastern Poland. Materials and methods: The study was conducted over the years 2006–2021. BMI was calculated, and physical fitness was assessed using the EUROFIT test. The results were statistically analyzed. Results: Minor changes in underweight were observed, and even a re-duction in its prevalence among girls was …