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Articles 146821 - 146850 of 1810509
Full-Text Articles in Entire DC Network
Use Of The Integrated Practice Assessment Tool (Ipat) To Evaluate The Clinical Learning Environment For Counselors-In-Training, Jessica Lloyd-Hazlett, Stacy Ogbeide, Heather Trepal, Mercedes Ingram, Swathi Weaver
Use Of The Integrated Practice Assessment Tool (Ipat) To Evaluate The Clinical Learning Environment For Counselors-In-Training, Jessica Lloyd-Hazlett, Stacy Ogbeide, Heather Trepal, Mercedes Ingram, Swathi Weaver
Journal of Human Services Scholarship and Interprofessional Collaboration
The need for behavioral health integration (BHI) in primary care continues to grow to address the behavioral health needs of patients and families. Developing a competent interprofessional workforce to operate in primary care behavioral health settings necessitates BHI-literate clinical learning environments, as well as tools to evaluate and assist in the integration of services appropriate for BHI training and supervision. The Integrated Practice Assessment Tool (IPAT; Waxmonsky et al., 2014) is an instrument that assesses the level of BHI at a primary care clinic. This paper discusses an example of an implementation approach to examine BHI levels with the IPAT …
Ideas For Professional Development In The Nonprofit Sector, Elise Lael Kieffer
Ideas For Professional Development In The Nonprofit Sector, Elise Lael Kieffer
Journal of Nonprofit Innovation
The nonprofit and nongovernmental sector serves the critical role, in our world, of filling in the gaps in service and opportunity that are unfulfilled by the public sector and either unfilled or unobtainable through the private sector. This thought paper presents one option for a professional development program for nonprofit professionals working in rural communities. This program serves to facilitate the training of nonprofit employees and volunteers in critical leadership and management education. Through this educational opportunity, nonprofit leaders, board members, and aspiring nonprofit directors come together in a cohort of peers to learn both foundational and advanced theories, strategies, …
Covid-19 And Health Equity: Lessons Learned From The Pandemic, Sumaya Ali, Lakell Archer, Erica L. Jensen
Covid-19 And Health Equity: Lessons Learned From The Pandemic, Sumaya Ali, Lakell Archer, Erica L. Jensen
Journal of Nonprofit Innovation
Health inequities refer to avoidable, unjust differences in health outcomes caused by systemic disadvantages rooted in social, economic, and environmental contexts (Braveman, 2014). Health disparities refer to differences in health outcomes between groups, often measured by prevalence, morbidity, or mortality (Centers for Disease Control and Prevention [CDC], 2020). Health inequalities are measurable differences in health status that may arise from biological, social, or environmental factors (World Health Organization [WHO], 2019). Health inequities, however, are specifically preventable and unjust differences.
The COVID-19 pandemic highlighted these inequities, intensifying pre-existing structural disparities within healthcare and societal systems. The pandemic underscored the urgency of …
Mass Shootings In The United States, Sydney Livingston
Mass Shootings In The United States, Sydney Livingston
Journal of Nonprofit Innovation
High rates of mass shootings are becoming a uniquely American problem; the US makes up 73% of the world’s mass shootings, yet makes up only 4.25% of the world’s population. School shootings, in particular, have increased dramatically in the US since the Columbine High School shooting in 1999, an event many perpetrators have since drawn upon as inspiration. There is a strong divide of opinions in the nation regarding how firearm deaths should be reduced, which has complicated and slowed progress in identifying effective solutions. Each mass shooting causes additional shootings to occur, and each one takes a toll on …
The Effect Of Gerrymandering On State Social Policy, Gary D. Brinker
The Effect Of Gerrymandering On State Social Policy, Gary D. Brinker
Sociology Faculty Publications
Partisan bias occurs when one party gets something the other party does not. If a given district map results in one party gleaning a higher proportion of the legislative seats than the proportion of votes cast for that party, since this effect is only possible for one party, then partisan bias has occurred. It can be strategically produced via gerrymandering and is thought by many to circumvent the basic principles of democracy. This study uses recent state election results to compute a measure of partisan bias, as well as secondary data measuring the levels of five state social policies, to …
Impacts Of Climate Change In The United States, Nathan T. Thompson
Impacts Of Climate Change In The United States, Nathan T. Thompson
Journal of Nonprofit Innovation
Climate change, a shift in long-term climate patterns primarily driven by anthropogenic factors, poses a super wicked problem impacting every sector and region globally, including the United States. This paper explores the scientific basis of climate change, its contributing factors, and the myriad consequences on terrestrial and aquatic systems, as well as mental health. Notably, the emission of greenhouse gases from fossil fuels and agricultural activities is the primary cause, exacerbated by ideological division and psychological distance. The U.S. has seen some progress with a 7% decrease in emissions over the past 30 years and a growing shift toward renewable …
Tribes And Ai: Possibilities For Tribal Sovereignty, Adam Crepelle
Tribes And Ai: Possibilities For Tribal Sovereignty, Adam Crepelle
Duke Law & Technology Review
Artificial Intelligence (AI) has permeated every facet of modern existence. Governments across the globe are exploring its applications and attempting to establish regulatory frameworks. Numerous scholars have proffered recommendations for governing AI at the local, national, and international levels. However, as is often the case, Indian tribes have been neglected in AI policy discussions. This oversight is significant because the 574 federally recognized tribes are sovereigns with their own judicial, education, and healthcare systems. Due to their relatively small populations and geographic isolation, tribes stand to benefit significantly from the services AI can perform. Moreover, tribes are uniquely well-suited to …
Managing Menopause: The Evolving Role Of Estrogens, Selective Serotonin Reuptake Inhibitors, And Phytoestrogens In Balancing Hormonal Fluctuations, Cassande Besong, Sandy Philippeaux, Ansa Bham, Naicha Gustinvil, Abigayle Castine, Giustino Varrassi, Patricia Sutker, Benjamin C. Miller, Caroline R. Burroughs, Sonja Gennuso, Sahar Shekoohi, Alan D. Kaye
Managing Menopause: The Evolving Role Of Estrogens, Selective Serotonin Reuptake Inhibitors, And Phytoestrogens In Balancing Hormonal Fluctuations, Cassande Besong, Sandy Philippeaux, Ansa Bham, Naicha Gustinvil, Abigayle Castine, Giustino Varrassi, Patricia Sutker, Benjamin C. Miller, Caroline R. Burroughs, Sonja Gennuso, Sahar Shekoohi, Alan D. Kaye
School of Medicine Faculty Publications
Menopause is characterized by the cessation of menstruation for 12 consecutive months. In this narrative review, we describe the transitional stages of menopause, clinical presentation, pharmacological management of symptoms, and effects on fluctuating hormone levels. To standardize the stages of menopause, the Stages of Reproductive Aging Workshop + 10 (STRAW+10) system was designed with five distinct categories corresponding to symptom presentation and numerical years. Common clinical presentations consist of vasomotor hot flashes, mood changes, decreased libido, osteoporosis, and genitourinary changes, all of which are associated with changes in hormone levels. Because hormones play a major role in the mechanism of …
101st Annual Inspire Bible Lectureship Program (2024), Harding University
101st Annual Inspire Bible Lectureship Program (2024), Harding University
Lectureship Programs
This document contains the printed lectureship schedule.
The Sphere Of Exposure: Centering User Experience In Community Science Air Monitoring, Marisa Westbrook, Valentina Serrano-Salomón, Jay Pecenka, Sumit Sankhyan, Aniya K. Hollo, Shelly L. Miller, Esther Sullivan
The Sphere Of Exposure: Centering User Experience In Community Science Air Monitoring, Marisa Westbrook, Valentina Serrano-Salomón, Jay Pecenka, Sumit Sankhyan, Aniya K. Hollo, Shelly L. Miller, Esther Sullivan
OHSU-PSU School of Public Health Faculty Publications and Presentations
Community science has increased in popularity in communities where residents hope to investigate the relationship between environmental issues and personal health. This study partnered with neighborhoods in the most polluted residential zip code in the US to conduct community science air quality monitoring. We conducted 60 semi-structured interviews after two monitoring deployments to understand participants’ subjective experiences of pollution exposure, their engagement with low-cost air quality monitors, and their data interpretation. We utilize the environmental health concept ‘exposure experience’ to analyze how participants use personal monitors, understand their data, and reinterpret their pollution exposure as a result. We further explore …
Addressing Adolescent Suicide In South Korea, Alyssa Kang
Addressing Adolescent Suicide In South Korea, Alyssa Kang
Journal of Nonprofit Innovation
Suicide is a prevalent issue that widely affects all demographics in South Korea. Among adolescents, it is the leading cause of mortality with an average rate of 7 deaths per 100,000 people. Some of the most significant factors that influence the risk of suicidal ideation and attempts are cultural stigma and academic stress. Other factors, such as bullying and family structure, also increase the likelihood of suicide, while specific characteristics including internet addiction, socioeconomic status, and substance abuse have been found to be predictors of suicide. Adolescent suicide attempts in Korea also increase the individual's risk for future attempts, and …
Research Summaries: Global Health, Lakell Archer, Sumaya Ali, Erica Jensen
Research Summaries: Global Health, Lakell Archer, Sumaya Ali, Erica Jensen
Journal of Nonprofit Innovation
No abstract provided.
Considering Ai For The Classroom To Boost Civic Learning And Democratic Engagement, Joseph P. Zompetti, Lance R. Lippert, Stephen K. Hunt
Considering Ai For The Classroom To Boost Civic Learning And Democratic Engagement, Joseph P. Zompetti, Lance R. Lippert, Stephen K. Hunt
eJournal of Public Affairs
Artificial Intelligence (AI) poses significant risks to society generally and higher education specifically. However, it offers potential benefits in terms of students’ civic learning and democratic engagement. By equipping students with the skills to use AI for the common good and fostering their awareness of the potential dangers of AI, we can bolster democracy. In this article, we explore the status quo along with expectations and near-term predictions for AI. Next, we explore some of the most significant and common concerns related to AI. Finally, we draw upon a variety of resources, identify “best practices,” analyze the strengths and weaknesses …
Who Pays The Price For The Cost Of Voting: The Impact Of Voting Policies On Presidential Election Turnout, 1996-2016, Amelia S. Minkin
Who Pays The Price For The Cost Of Voting: The Impact Of Voting Policies On Presidential Election Turnout, 1996-2016, Amelia S. Minkin
eJournal of Public Affairs
The gap between the percentage of registered White voters who cast a ballot and that of registered nonwhite voters in the 2020 United States Presidential election was approximately 13 percent. This trend varies widely across the United States due to state legislators having jurisdiction to craft, enact, and implement election and voting legislation. In 2022, 408 pieces of legislation that would have made it more difficult to register to vote, cast a ballot, or stay on the voter rolls were considered in 39 states and 11 made it into state codes across the country. Given the increase in legislation considered …
Effects Of Gerrymandering On State Social Policy, Gary D. Brinker
Effects Of Gerrymandering On State Social Policy, Gary D. Brinker
eJournal of Public Affairs
Partisan Bias occurs when an election results in a party gleaning a significantly different proportion of legislative seats than the proportion of votes cast for that party. It can be strategically produced via gerrymandering and is thought by many to threaten the basic principles of democracy. This research uses the 2022 state election results to compute statewide measures of Partisan Bias, then analyzes the correlation with controversial state social policies. Results showed that the redistricting method used and the percent of the party’s legislators were related to Partisan Bias. Analysis also showed that Partisan Bias explains significant levels of variance …
From Institutional Trauma To Institutional Healing, Molly B. Kerby, Gayle M. Mallinger
From Institutional Trauma To Institutional Healing, Molly B. Kerby, Gayle M. Mallinger
eJournal of Public Affairs
The societal struggles in American higher education have intensified in recent years, impacting various facets of academic life. Enrollment declines, rising costs, student debt, and emerging alternatives pose significant threats to colleges and universities. The COVID-19 pandemic further strained institutions, leading to deeper budget cuts and potential closures. Falling tuition revenue coupled with culture wars and political polarization have led to prolonged institutional trauma in higher education institutions. Conservative-leaning states have restricted faculty tenure, courses dealing with social and political inequity, and DEI initiatives, while progressives emphasize universities' role in fostering critical thinking and truth.
Organizational trauma can significantly impact …
Effects Of White Matter Hyperintensity Burden On Functional Outcome After Mild Versus Moderate-To-Severe Ischemic Stroke, Dong-Seok Gwak, Wi-Sun Ryu, Dawid Schellingerhout, Jinyong Chung, Hang-Rai Kim, Sang-Wuk Jeong, Beom Joon Kim, Joon-Tae Kim, Keun-Sik Hong, Jong-Moo Park, Man-Seok Park, Kang-Ho Choi, Tai Hwan Park, Kyungbok Lee, Sang-Soon Park, Kyusik Kang, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi-Sun Oh, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Moon-Ku Han, Ji Sung Lee, Hee-Joon Bae, Dong-Eog Kim
Effects Of White Matter Hyperintensity Burden On Functional Outcome After Mild Versus Moderate-To-Severe Ischemic Stroke, Dong-Seok Gwak, Wi-Sun Ryu, Dawid Schellingerhout, Jinyong Chung, Hang-Rai Kim, Sang-Wuk Jeong, Beom Joon Kim, Joon-Tae Kim, Keun-Sik Hong, Jong-Moo Park, Man-Seok Park, Kang-Ho Choi, Tai Hwan Park, Kyungbok Lee, Sang-Soon Park, Kyusik Kang, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi-Sun Oh, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Moon-Ku Han, Ji Sung Lee, Hee-Joon Bae, Dong-Eog Kim
Faculty, Staff and Student Publications
It is uncertain whether the prognostic power of white matter hyperintensity (WMH) on post-stroke outcomes is modulated as a function of initial neurological severity, a critical determinant of outcome after stroke. This multi-center MRI study tested if higher WMH quintiles were associated with 3-month poor functional outcome (modified Rankin Scale ≥ 3) for mild versus moderate-to-severe ischemic stroke. Mild and moderate-to-severe stroke were defined as admission National Institute of Health Stroke Scale scores of 1-4 and ≥ 5, respectively. Mean age of the enrolled patients (n = 8918) was 67.2 ± 12.6 years and 60.1% male. The association between WMH …
Introduction From Chapman Rackaway, Chapman Rackaway
Introduction From Chapman Rackaway, Chapman Rackaway
eJournal of Public Affairs
No abstract provided.
The Time Is Now, The Time Is Always: Moving Civics From The Classroom To The Campus, Amanda O. Maher, Brigid Beaubien
The Time Is Now, The Time Is Always: Moving Civics From The Classroom To The Campus, Amanda O. Maher, Brigid Beaubien
eJournal of Public Affairs
The time could not be more urgent, and university faculty and leaders must act and reclaim their responsibility for civic preparation. In the face of enrolment decline, an emphasis on student credit hours, and a history of siloed tunnel vision, action seems impossible in a climate that resists the core mission of higher education. In this article, authors—faculty from two teacher preparation departments—share their journey that started as state-mandated program revision to a campus-wide civic agenda. They argue for the integration of civics teaching in disciplinary courses and share classroom teaching ideas that cultivate civic identity and virtues. Feeling empowered, …
Longitudinal Relations Between Parenting Practices And Prosocial Behaviors In Recent Immigrant Latino/A Adolescents: Familism Values And Ethnic Identity As Mediators, Sahitya Maiya, Gustavo Carlo, Alexandra N. Davis, Seth J. Schwartz, Jennifer B. Unger, Byron L. Zamboanga, Lourdes Baezconde-Garbanati, Daniel W. Soto, Elma I. Lorenzo-Blanco
Longitudinal Relations Between Parenting Practices And Prosocial Behaviors In Recent Immigrant Latino/A Adolescents: Familism Values And Ethnic Identity As Mediators, Sahitya Maiya, Gustavo Carlo, Alexandra N. Davis, Seth J. Schwartz, Jennifer B. Unger, Byron L. Zamboanga, Lourdes Baezconde-Garbanati, Daniel W. Soto, Elma I. Lorenzo-Blanco
Psychological Science Faculty Publications and Presentations
Introduction:
The present study investigated the mediating roles of familism values and ethnic identity in longitudinal associations between recent immigrant U.S. Latino/a adolescents' reports of their parents' (i.e., mothers' and fathers') use of social and material rewards and prosocial behaviors.
Methods:
Participants included 302 recent immigrant U.S. Latino/a adolescents (M age = 14.5 years at Time 1, range = 13–17 years, 53% male) recruited from Los Angeles and Miami. Participants self-reported on their perceptions of parents' use of social and material rewards (Time 1), familism values (Time 3), ethnic identity (Time 5), and multiple types of prosocial behaviors (Time …
Negative Effect Of Treatment With Mglur5 Negative Allosteric Modulator Afq056 On Blood Biomarkers In Young Individuals With Fragile X Syndrome, Dragana Protic, Stephanie Morris, Et Al.
Negative Effect Of Treatment With Mglur5 Negative Allosteric Modulator Afq056 On Blood Biomarkers In Young Individuals With Fragile X Syndrome, Dragana Protic, Stephanie Morris, Et Al.
2020-Current year OA Pubs
BACKGROUND: Fragile X syndrome, with an approximate incidence rate of 1 in 4000 males to 1 in 8000 females, is the most prevalent genetic cause of heritable intellectual disability and the most common monogenic cause of autism spectrum disorder. The full mutation of the Fragile X Messenger Ribonucleoprotein-1 gene, characterized by an expansion of CGG trinucleotide repeats (>200 CGG repeats), leads to fragile X syndrome. Currently, there are no targeted treatments available for fragile X syndrome. In a recent large multi-site trial, FXLEARN, the effects of the mGluR5 negative allosteric modulator, AFQ056 (mavoglurant), were investigated, but did not show …
Il-8, Tnf-Α, And Il-17 In The Development Of Erosive Esophagitis And Symptom Perception In Gastroesophageal Reflux Disease (Gerd), Michael Austin Pradipta Lusida, Isna Mahmudah, Hafeza Aftab, Ratha-Korn Vilaichone, Yoshio Yamaoka, Hoda M Malaty, Muhammad Miftahussurur
Il-8, Tnf-Α, And Il-17 In The Development Of Erosive Esophagitis And Symptom Perception In Gastroesophageal Reflux Disease (Gerd), Michael Austin Pradipta Lusida, Isna Mahmudah, Hafeza Aftab, Ratha-Korn Vilaichone, Yoshio Yamaoka, Hoda M Malaty, Muhammad Miftahussurur
Faculty, Staff and Students Publications
Background: The diverse clinical characteristics of erosive esophagitis (EE) and symptom perception in patients with gastroesophageal reflux disease (GERD) remain a major challenge in understanding their underlying pathogenesis. This study aimed to investigate the association between the levels of IL-8, TNF-α, and IL-17 in serum and the presence of erosive esophagitis and symptoms related to GERD. Method: We enrolled 65 subjects presenting with GERD symptoms. Based on the findings of upper endoscopy, the subjects were categorized into two groups: (1) erosive esophagitis (EE LA grades B-D) and (2) non-erosive esophagitis (normal-EE LA grade A). Symptom perception was assessed via GERD …
Volume 55-2 Complete Issue, Steven M. Schnell
Volume 55-2 Complete Issue, Steven M. Schnell
The Geographical Bulletin
Volume 55-2 Complete Issue
Spatial Crime Displacement On Chicago’S South Side, David Melsness, Ryan Weichelt
Spatial Crime Displacement On Chicago’S South Side, David Melsness, Ryan Weichelt
The Geographical Bulletin
This research examines the effects of population displacement after the demolition of the Robert Taylor Homes (in Chicago’s 2nd Police District) on crime in neighboring police districts that serve impoverished, racially segregated, high-crime neighborhoods where many former residents relocated. The objective is to analyze possible relationships between the demolition of the housing project and crime trends of murder, robbery, and total reported index crime in surrounding police districts and police beats through the use of hotspot analysis.
Global Burden Of Bacterial Antimicrobial Resistance 1990–2021: A Systematic Analysis With Forecasts To 2050, Gbd 2021 Antimicrobial Resistance Collaborators, Geminn Louis C. Apostol
Global Burden Of Bacterial Antimicrobial Resistance 1990–2021: A Systematic Analysis With Forecasts To 2050, Gbd 2021 Antimicrobial Resistance Collaborators, Geminn Louis C. Apostol
Ateneo School of Medicine and Public Health Publications
Background
Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed estimates for several WHO regions by country. To date, there have been no studies that produce comprehensive estimates of AMR burden across locations that encompass historical trends and future forecasts.
Methods
We estimated all-age and age-specific deaths and disability-adjusted life-years (DALYs) attributable to and associated with bacterial AMR for 22 pathogens, 84 pathogen–drug combinations, and 11 infectious syndromes in 204 countries and territories from …
A Multicenter, Randomized, Non-Comparative, Phase Ii Study Of Nivolumab ± Ipilimumab For Patients With Metastatic Sarcoma (Alliance A091401): Expansion Cohorts And Correlative Analyses, Nathan D Seligson, James L Chen, Austin C Goodrich, Brian A Van Tine, Jordan D Campbell, Allison L Richards, Cristina R Antonescu, David A Liebner, Mohammed M Milhem, Howard Streicher, William D Tap, Gary K Schwartz, Suzanne George, Sandra P D'Angelo
A Multicenter, Randomized, Non-Comparative, Phase Ii Study Of Nivolumab ± Ipilimumab For Patients With Metastatic Sarcoma (Alliance A091401): Expansion Cohorts And Correlative Analyses, Nathan D Seligson, James L Chen, Austin C Goodrich, Brian A Van Tine, Jordan D Campbell, Allison L Richards, Cristina R Antonescu, David A Liebner, Mohammed M Milhem, Howard Streicher, William D Tap, Gary K Schwartz, Suzanne George, Sandra P D'Angelo
2020-Current year OA Pubs
BACKGROUND: In this open-label, randomized, non-comparative, multicenter phase II study (Alliance A091401) we report on three expansion cohorts treated with nivolumab (N) with and without ipilimumab (N+I) and provide a multi-omic correlative analysis of actionable biomarkers.
METHODS: Patients were randomized (non-comparative) to receive either N or N+I. The primary endpoint was a 6-month confirmed response rate (CRR) defined by Response Evaluation Criteria in Solid Tumors version 1.1. Secondary endpoints included treatment-related adverse events (TRAEs), progression-free survival, and overall survival. Multi-omic correlative analyses were conducted using samples from both the primary and expansion cohorts.
RESULTS: A total of 66 patients were …
S6k1 Controls Dna Damage Signaling Modulated By The Mrn Complex To Induce Radioresistance In Lung Cancer, Ali Calderon-Aparicio, Jun He, Nicole L. Simone
S6k1 Controls Dna Damage Signaling Modulated By The Mrn Complex To Induce Radioresistance In Lung Cancer, Ali Calderon-Aparicio, Jun He, Nicole L. Simone
Department of Radiation Oncology Faculty Papers
Radiation is a mainstay of lung cancer treatment; however, resistance frequently develops. Identifying novel therapeutic targets to increase radiation sensitivity is crucial. S6K1 is a serine/threonine kinase known to regulate protein translation which is associated with radioresistance, but the mechanisms involved are unknown. We proposed to determine whether S6K1 promotes radioresistance by regulating DNA repair in lung cancer. Colony formation, protein expression and proliferation were assessed. S6K1 was modulated pharmacologically by either PF-4708671 or genetically by Crispr-Cas9. Higher radioresistance levels in lung cancer cells were associated with lower phosphoactivation of MRN complex members, a key activator of radiation-induced DNA repair …
Nanopore Signal Deviations From Pseudouridine Modifications In Rna Are Sequence-Specific: Quantification Requires Dedicated Synthetic Controls, Amr Makhamreh, Sepideh Tavakoli, Ali Fallahi, Xinqi Kang, Howard Gamper, Mohammad Nabizadehmashhadtoroghi, Miten Jain, Ya-Ming Hou, Sara H Rouhanifard, Meni Wanunu
Nanopore Signal Deviations From Pseudouridine Modifications In Rna Are Sequence-Specific: Quantification Requires Dedicated Synthetic Controls, Amr Makhamreh, Sepideh Tavakoli, Ali Fallahi, Xinqi Kang, Howard Gamper, Mohammad Nabizadehmashhadtoroghi, Miten Jain, Ya-Ming Hou, Sara H Rouhanifard, Meni Wanunu
Department of Biochemistry and Molecular Biology Faculty Papers
Chemical modifications to mRNA respond dynamically to environmental cues and are important modulators of gene expression. Nanopore direct RNA sequencing has been applied for assessing the presence of pseudouridine (ψ) modifications through basecalling errors and signal analysis. These approaches strongly depend on the sequence context around the modification, and the occupancies derived from these measurements are not quantitative. In this work, we combine direct RNA sequencing of synthetic RNAs bearing site-specific modifications and supervised machine learning models (ModQuant) to achieve near-analytical, site-specific ψ quantification. Our models demonstrate that the ionic current signal features important for accurate ψ classification are sequence …
Urinary Tract Infection Caused By Gardnerella Vaginalis In A 6 Week Old Infant, Rhythm Sharma, Malika Goel, Ruba Barbar
Urinary Tract Infection Caused By Gardnerella Vaginalis In A 6 Week Old Infant, Rhythm Sharma, Malika Goel, Ruba Barbar
Conference Presentation Abstracts
Introduction: Gardnerella vaginalis is a frequent cause of bacterial vaginosis (BV) in adults. However, G. vaginalis infection is infrequent in infants. Only a few cases of G. vaginalis UTI have been reported so far in infants and none in the United States.
Case Description: A 6-week-old female, ex full-term at 39 3/7 weeks via vaginal delivery with no significant postnatal medical history, presented with a 2-day history of fever, mild cough, and congestion.
In the emergency department, the patient was febrile to 38.1°C, pulse 139 beats/minute, respiratory rate 34 breaths/minute, and SpO2 98% on room air. She was active and …