Digital Commons Network^™

Screening Key Factors In Cassava-Based Bioethanol Production By Simultaneous Saccharification And Fermentation, Safri Ishmayana, Alief R. P. Andrianto, Shinta D. R. Apandi, Debora Tamaris Horasio, Muhammad Fadhlillah, Irwan Kurnia, Riza Apriani, Fajriana S. Nurrusyda, Ukun M. S. Soedjanaatmadja

Baghdad Science Journal

Simultaneous saccharification and fermentation (SSF) is considered an efficient approach for bioethanol production from starchy biomass, although its performance is often affected by multiple variables acting at different stages of the process. In the present study, Plackett–Burman experimental design was used as a screening method to evaluate factors affecting ethanol production from cassava flour using Saccharomyces cerevisiae. Eleven variables related to both liquefaction and SSF stages were examined, including temperature, pH, processing time, agitation, enzyme loading, nitrogen supplementation and inoculum level, arranged in twelve experimental runs. As the experimental design was performed without replication, the effect of each variable …

Evaluation Of Serum Eotaxin And Related Biomarkers In Focal And Generalized Epilepsy, Fenik Ahmed Nadir, Firas Shawqi Algburi, Zeyan Abdullah Ali, Shaima Ahmed Nadir

Baghdad Science Journal

Epilepsy is a common brain disorder, characterized by spontaneous recurrent seizures, with associated neuropsychiatric and cognitive comorbidities and increased mortality. Assessment of serum Eotaxin and related biomarkers offers useful information about neuroinflammatory activity and metabolic imbalance in epilepsy, and may have potential value as diagnostic and prognostic tools. The aim of this study was to evaluate the association between Eotaxin, Intelectin-1, Kynurenine, and Proprotein Convertase-1 and epilepsy. The study consisted of 90 subjects who were classified into three groups: 30 healthy controls, 31 patients with focal epilepsy, and 30 patients with generalized epilepsy. Serum samples were obtained, and biomarker concentrations …

The Phosphatidylinositol 3-Kinase As A Potential Diagnostic Marker For Beta-Thalassemia And Its Correlation With Hemoglobin Profiles, Duaa K. Mohammed, Layla O. Farhan

Baghdad Science Journal

The erythropoietic dysfunction and iron insufficiency associated with β -Thalassemia (β -TH) underscore the importance of augmenting traditional diagnostic techniques with independent biomarkers, beyond standard panels. This single-center case–control study (n = 120 β -TH major, 55; β -TH intermedia, 25; control, 40) examined whether circulating phosphatidylinositol-3-kinase (PI3K) distinguishes patients from controls and correlates with hemoglobin fractions. The serum PI3K was significantly higher in β -TH (p < 0.001), with excellent discrimination tested in serum (AUC = 0.934; optimal cut-off > 1301 pg/mL; sensitivity 100%, specificity 80%). In a multivariable model, HbA₂% and HbF% were both positively and independently associated with PI3K. These results are biologically consistent with the interaction of erythroid …

Integrating Social Determinants Of Health And Temporal Patterns With Wastewater-Based Drug Surveillance In El Paso, Texas, Arav Wijesinghe

Summer Research Program Abstracts

No abstract provided.

Cardiac Resynchronization Therapy: A Review, Caique M Ternes, Jitae A Kim, Anirban Basu, Kenneth A Ellenbogen, Mihail G Chelu

Faculty, Staff and Students Publications

Importance: Heart failure (HF) affects more than 64 million individuals worldwide, and acute HF is associated with 1-year mortality rates of 23.6% in North America and Europe. Cardiac dyssynchrony from conduction system disease may cause HF progression, particularly in patients with left ventricular (LV) systolic dysfunction.

Observations: Electrical dyssynchrony in HF most commonly presents as left bundle-branch block and affects 20% to 30% of patients with reduced LV ejection fraction (LVEF). Cardiac resynchronization therapy, which includes biventricular pacing and conduction system pacing, restores synchronous ventricular contraction and is recommended for patients with symptomatic HF despite optimal medical therapy, LVEF of …

Regulation Of Pfh1 Helicase Activity By Nucleic Acid Interactions And Mitochondrial Ssb, María Ortiz-Rodríguez, Saurabh P Singh, Francisco J Cao-García, Roberto Galletto, Borja Ibarra

2020-Current year OA Pubs

Pif1-family helicases are essential for proper nuclear and mitochondrial genome maintenance, yet the regulation of their activities remains incompletely understood. Here, we use single-molecule manipulation and visualization techniques to dissect the real-time mechanochemical behavior of Pfh1, the sole Pif1-family helicase in

T2b Gallbladder Adenocarcinoma Diagnosed By Frozen Section With High-Grade Dysplasia At The Cystic Duct Margin: Diagnostic And Prognostic Considerations, Christopher M. Ahmad, Rachana Tadakamalla, Rae-Anne Kastle, Salman Muqeet, Amer Abboud

Student Publications

Gallbladder adenocarcinoma is an uncommon gastrointestinal malignancy that is frequently discovered incidentally during cholecystectomy. Intraoperative frozen section is often used to guide surgical decision-making but has inherent limitations, particularly in assessing depth of invasion. We report the case of a 78-year-old female who underwent an elective laparoscopic cholecystectomy for a gallbladder mass. Intraoperative frozen section demonstrated a tubulovillous adenoma with at least carcinoma in situ. Subsequent permanent histologic evaluation revealed a moderately differentiated adenocarcinoma invading the hepatic-side perimuscular connective tissue, consistent with pT2b disease. Despite the advanced T stage, the tumor exhibited several relatively favorable histologic features, including negative margins …

Comprehensive Mass Spectrometry Screening-Derived Atlas Of Hdac Inhibitors Reveals Histone-Specific Acetylation Changes, Rashmi Karki, Francisca N De Luna Vitorino, Richard M Searfoss, Joanna K Lempiäinen, Cheryl H Arrowsmith, Benjamin A Garcia

2020-Current year OA Pubs

Histone deacetylase inhibitors (HDACis) have emerged as valuable therapeutics for cancer and other diseases; however, their effects on histone post-translational modification remain poorly characterized. Here, we applied quantitative mass spectrometry and high-throughput sequencing to systematically profile site-specific changes in histone modifications in response to a panel of HDACis. This platform enabled mapping of histone modification changes across hundreds of sites, including low-abundance histone marks. Furthermore, an integrative analysis of chromatin immunoprecipitation followed by sequencing (ChIP-seq) and RNA-sequencing (RNA-seq) data identified genome-wide binding sites for the low-abundance histone modification of H2A.Z acetylation in HeLa and MDA-MB-231 breast cancer cells, highlighting the …

Recognizing Early Eating Disorder Signs In Pediatrics, Sarah Gubara, Sara R. Gould

Pediatrics in Practice: A CME Podcast

A concise guide for frontline clinicians on early physical and behavioral red flags — changes in growth trajectory, micronutrient concerns, exam‑time anxiety or sudden “healthy” eating shifts. Dr. Sara Gould emphasizes practical 24‑hour recalls, when to order labs/EKG and how to use longitudinal data from well visits to detect problems sooner.

Click here to stream the podcast episode.

Modulate Obesity And Related Metabolic Complications For Yielding Improvements In Ibd Outcomes (Modify-Ibd): Consensus On Obesity And Cardiometabolic Comorbidities In Inflammatory Bowel Disease Using Systematic Reviews And The Rand/Ucla Appropriateness Method, Jalpa Devi, Sami Samaan, Priya Sehgal, Mouhand Mohamed, Matthew Vincent, Shannon Coombs, Michelle Doering, Edward L. Barnes, Amanda M. Johnson, Andres J. Yarur, Parakkal Deepak

Division of Gastroenterology and Hepatology Faculty Papers

INTRODUCTION: Obesity and related cardiometabolic comorbidities, including hypertension, dyslipidaemia, diabetes, metabolic dysfunction-associated steatotic liver disease and atherosclerotic cardiovascular disease, are increasingly prevalent among individuals with inflammatory bowel disease (IBD). These conditions influence disease activity, therapeutic response, surgical outcomes and overall quality of life, yet evidence remains fragmented. The Modulate Obesity and relateD metabolic complIcations For Yielding improvements in IBD outcomes (MODIFY-IBD) initiative aims to synthesise evidence and generate consensus recommendations to guide practice and future research in this area. This study describes a protocol for a structured evidence synthesis and Research And Development/University of California, Los …

Evaluation Of Incidence Of Radiation Induced Kidney Injury With Y-90 Radioembolization, Apurva Veeraswamy

Summer Research Program Abstracts

No abstract provided.

Mining And Sustainable Development In Sierra Leone: The Role Of Institutional Quality, Ibrahim Massaquoi

Journal of Sustainable Mining

While mining can drive economic growth, create jobs, and promote infrastructural development, it also poses risks to the environment, human health, and social well-being. Therefore, to achieve sustainable development, responsible mining is crucial. This study empirically examines the role of institutional quality in the mining-sustainable development nexus in Sierra Leone. With the use of the planetary pressures-adjusted human development index (PHDI) as a comprehensive measure of sustainable development, the study is able to integrate economic, social, and environmental dimensions. The autoregressive distributed lag (ARDL) model confirms the existence of both short-run and long-run dynamics. The results of the study show …

The Impact Of Sustainable Responsible Investment On The Environmental And Financial Performance Of Listed Companies (In The Context Of European Regulatory Framework), Leila Kamara

Engaged Management ReView

Although socially responsible investment (SRI) first emerged in the United States in the 1970s, its influence is now global and booming. The most striking illustration is the increase of signatories to the United Nations Principles for Responsible Investment (PRI): The number of signatories surged from around 100 in 2006 to more than 5,000 in 2025 (Peillex & Comyns, 2020), confirming that SRI is now central to investment strategies. The landscape of environmental, social, and governance (ESG) investment has seen the emergence of new stakeholders, including data providers. However, persistent limitations regarding data transparency, accessibility, and comparability have prevented investors from …

Gci Vortex Microbubble Refiner (Vmr) V2.5‑T “Titan”, Michael Victor Caldwell Mr.

Defensive Publications Series

The Vortex Microbubble Refiner (VMR) v2.5‑T “Titan” is a conceptual plasma–acoustic hybrid designed for complete mineralization of PFAS, microplastics, and persistent organic pollutants. It integrates geometry‑induced cavitation, microbubble plasma discharge, zirconium‑based MOF sensing surfaces, and adaptive AI‑regulated pulsed flow. The system uses hydrodynamic energy to generate cavitation and requires only a low‑current plasma spark to ionize argon microbubbles. Titan v2.5‑T includes dual‑stage counter‑current cavitation, zeolite cold‑trap off‑gas recycling, ceramic hardfacing for durability, and real‑time chemical detection. This disclosure is conceptual only and requires expert validation before any real‑world implementation.

Multi-Cloud Latency-Aware Ledger Synchronization Layer System And A Method Thereof, Ananya Verma, Raouf Khan

Defensive Publications Series

The present disclosure relates to a multi-cloud latency-aware ledger synchronization layer system for maintaining consistency of payment networks across geographically distributed data centers. The system includes a distributed telemetry mesh configured to continuously measure inter-cloud network performance metrics such as latency, jitter, and packet loss. Furthermore, the system employs a latency surface modeling engine configured to construct a dynamic latency surface model based on the measured metrics. A synchronization scheduler is then configured to select replication targets and timing windows for ledger updates based on real-time assessments of the latency surface model and compliance constraints, ensuring that critical updates are …

Virtual/Augmented Reality Paired Driving Using Digital Key Enabled Device For Pairing/Authentication, Nick Miller, Emelie Jess Ashdown

Defensive Publications Series

This disclosure describes a system for safely driving a vehicle from a remote location using an extended reality (XR) headset, virtual reality (VR) goggles, augmented reality (AR) glasses, or a hardware simulator. Existing remote driving, tele-operation, or remote vehicle control methods often rely on simple passwords, which can be less secure. This new technique uses a high-security digital car key stored on a physical device—such as a smartphone, an object tracking tag, or a small hardware “puck”—that should be placed inside the vehicle before it can be operated remotely. This creates a physical requirement that ensures only someone with authorized …

Edge Artificial Intelligence (Ai) Guardian: Ai-Powered Predictive And Self-Healing For Bidirectional Forwarding Detection (Bfd) And Internet Protocol Security (Ipsec) Tunnels In Software-Defined Wide Area Network (Sd-Wan), Krushnarajendra H R

Defensive Publications Series

Current Software-Defined Wide Area Network (SD-WAN) solutions are reactive and centralized, lacking the ability to predict and autonomously heal tunnel degradations before outages occur.  To address these limitations, the techniques presented herein implement Edge AI Guardian, a system configured to deploy a lightweight on-device Artificial Intelligence (AI) agent on edge routers to predict tunnel failures in real time, autonomously perform local self-healing actions, and generate natural-language Generative Artificial Intelligence (GenAI)-based root cause summaries without requiring centralized network management connectivity.

Enhancing Social Activity Through Climate-Adaptive Design In Hot-Humid Campus Open-Spaces: A Case Study Of The University Of Basrah In Iraq, Noor A. Almansor, Farah Ahmed Thiab, Riyam Rajab Fenjan

HBRC Journal

Outdoor open spaces between university buildings support students' community interactions and academic achievements. However, in hot-humid climate zones, some of these spaces lack activity and experience social withdrawal due to thermal discomfort. This is seen on the University of Basrah campus. To address this, the study aimed to identify the most suitable climate-adaptive design pattern to improve thermal comfort and, in turn, enhance students' social presence in the University of Basrah's neglected, peripheral outdoor campus spaces. A convergent mixed-method case study was applied. First, measurable environmental and social factors were identified from related studies. Next, two open spaces in the …

The Impact Of Climate Change On Glass Facades: A Bibliometric Analysis, Pelin Akın, Güneş Mutlu Avinç

HBRC Journal

Climate change has direct impacts on the design and performance of building envelopes, necessitating new approaches in the discipline of architecture. In this study, a bibliometric analysis was conducted to understand the effects of climate change on glass façade systems. The 612 academic publications obtained from the Web of Science database were analyzed through R Studio Biblioshiny. Within the scope of the study, publication trends, key themes, prominent authors, institutions and geographical distributions were evaluated in detail. According to the findings of the research, it was indicated that research has gained momentum especially after 2016, focusing on themes such as …

A Hybrid Deep Learning Framework For Multi-Class Retinal Disease Classification, Ali M. Duhaim, Abbas M. Al-Bakry

AUIQ Technical Engineering Science

Ocular diseases such as diabetic retinopathy, glaucoma, and cataract remain major causes of vision loss worldwide, creating an increasing demand for accurate and reliable automated diagnostic systems. Although deep learning techniques have demonstrated strong performance in retinal image analysis, their clinical adoption is still limited by challenges related to predictive reliability, robustness, and interpretability. This study presents HEFR-Net (Hybrid EfficientNet-B3 and ResNet-50 Feature-Fusion Network), a hybrid deep learning framework designed for multi-class classification of retinal fundus images. The proposed architecture integrates EfficientNet-B3 and ResNet-50 through feature-level fusion, enabling the model to capture both fine-grained texture patterns and high-level structural characteristics …

Automatically Managing Ai Fatigue Through Performance Tracking And Memory Summaries, Deep Raithatha, Tanmay Kayande

Defensive Publications Series

Generative artificial intelligence agents engaged in long-duration tasks often suffer from "contextual fatigue," a noticeable decline in reasoning quality and focus over time. To resolve this issue, an automated monitoring system can track the AI's internal word-choice patterns to detect early statistical signs of performance decay. Once this fatigue is identified, the system triggers a recovery process that temporarily pauses the main AI for a "sleep cycle." During this brief rest, a secondary AI reviews and condenses the primary agent's cluttered memory into a clean, dense summary. By resuming its task with this newly compressed information, the primary AI regains …

Ambient Pre-Conscious Intelligence (Api), Johny Manuel-Devadoss, Deepthi Prasad, Jayden Jack Johnson

Defensive Publications Series

Current artificial intelligence systems are, in practice, still largely reactive in nature. Even the most advanced assistants typically require explicit user prompts, clearly observable interaction events, or high-confidence inference of user intent before they engage in meaningful computational support. As a result, there is an inherent delay between the moment a cognitive need begins to emerge and the moment a system is able to respond. This delay is not merely a technical limitation; it introduces measurable friction into everyday human–computer interaction. In complex, information-dense environments, this friction accumulates, contributing to increased task-switching costs, reduced continuity of thought, and elevated cognitive …

Continuity Of Care For Alcohol Use Disorder Patients Using Telehealth During The Covid-19 Pandemic, Martine Beaubrun

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education To Improve Treatment Adherence Among Young Adults With Mental Health And Substance Use Disorders In An Outpatient Behavioral Health Clinic, Nkechinyere Eririma Nwachukwu

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education To Enhance Registered Nurses’ Knowledge And Utilization Of The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (Ciwa-Ar) Tool In An Inpatient Psychiatric Unit, Reign Staron Beri

Walden Dissertations and Doctoral Studies

No abstract provided.

Crime-Related Media Consumption And Fear Of Crime Victimization: The Moderating Roles Of Stress And Coping, Katelyn Elizabeth Byers

Walden Dissertations and Doctoral Studies

No abstract provided.

Improving Antihypertensive Medication Adherence Through Patient-Centered Assessment In Rural Primary Care, Tiesha Keoni Mathis

Walden Dissertations and Doctoral Studies

No abstract provided.

An Emotional Intelligence Staff Education Program For Patient-Aligned Care Team (Pact) Members, Linda Rogers

Walden Dissertations and Doctoral Studies

No abstract provided.

Perceived Concepts Which Influence Initial Methamphetamine Use Amongst Young Latina Women, Rebeca Rivera

Walden Dissertations and Doctoral Studies

No abstract provided.

Successful Strategies Leaders Of New Car Dealerships Use To Maximize Retention Of Salespeople, Kacey Patrice Taylor

Walden Dissertations and Doctoral Studies

No abstract provided.