Digital Commons Network^™

Clonal Reshaping And Clinical Outcomes After Rechallenge In Ici-Associated Myocarditis: Integrated Single-Cell And Tcr Repertoire Analysis, Jian Zhang, Xiaozhen He, Yerui Zhang, Xianling Qian, Yu Song, Shilong Zhang, Zheng Li, Zhiming Wang, Bo Lu, Qingqing Cai, Leilei Cheng, Yan Wang

Center for Translational Medicine Faculty Papers

BACKGROUND: Immune checkpoint inhibitor-associated myocarditis (ICIAM) poses significant challenges for cancer immunotherapy, particularly regarding the safety and efficacy of immune checkpoint blockade (ICB) rechallenge.

METHODS: The present study analyzed 23 cases of ICIAM by integrating longitudinal clinical data with single-cell RNA sequencing and T-cell receptor profiling of peripheral blood mononuclear cells (PBMCs) obtained from three representative patients before and after ICB rechallenge. The single-cell cohort comprised two patients who experienced recurrent irAEs upon rechallenge and one patient who did not develop recurrent irAEs.

RESULTS: Among 12 patients (52%) who experienced recurrent irAEs upon rechallenge, myocarditis recurrence occurred in 8 cases, …

Target Trial Of Glucagon-Like Peptide-1 Agonists Versus Dipeptidyl Peptidase-4 Inhibitors And Mortality In Hemodialysis, Dustin Le, Duncan Kilpatrick, Walter K. Kraft, Morgan E. Grams, Bernard G. Jaar, Jung-Im Shin

Division of Nephrology Faculty Papers

INTRODUCTION: The comparative effectiveness of glucagon-like peptide-1 (GLP-1) agonists (GLP-1s) versus dipeptidyl peptidase-4 (DPP-4) inhibitors (DPP-4s) in hemodialysis is unknown.

METHODS: Using 2011 to 2021 US Renal Data System and Medicare claims data, we emulated a target trial comparing new users of GLP-1s versus DPP-4s with patients who survived ≥ 90 days on in-center hemodialysis before medication initiation. We used inverse probability of treatment weighting (IPTW) and Cox proportional hazards models to estimate hazard ratios (HRs).

RESULTS: We identified 3671 GLP-1 and 12,039 DPP-4 users. After IPTW, mean age was 63 years, 52% male, 63% White, and mean body mass …

The Price Of The Pitch: When Repetitive Stress Can Cause Anatomical Developmental Abnormalities, Oswald Ramos Tuarez

Advocate GME

CASE HISTORY: 17 yo right-handed softball player presented to training room after a shoulder subluxation during overhead throw at scrimmage. She reported continued popping sensation and pain with overhead throws that did not improve with rest. She was able to continue underhand pitching and hitting with minimal pain. Minimal pain at rest. Started physical therapy but continued pain and feeling of grinding with overhead activities. Denied previous trauma, numbness, tingling or upper extremity weakness.

PHYSICAL EXAM: A0x3. Neck: No tenderness to palpation on the cervical spine, FROM of cervical spine. Negative spurling's. Right shoulder: FROM, Pain at end ROM with …

Widespread Concern Over Gas Prices In Nh As Consumer Confidence Shows Sudden Slump 5/28/2026, Unh Survey Center

All UNH Survey Center Polls

Six in ten New Hampshire residents are worried about paying for gas and believe gasoline prices will rise over the next twelve months. Two-thirds believe President Trump is very responsible for the increase in gasoline prices. As gas prices increase, Granite Staters are less positive about their personal finances compared to a year ago and many expect to be worse off a year from now. New Hampshire residents are also downbeat on the national economy, as nearly half anticipate bad times over the next year and two-thirds believe the economy is getting worse.

Hope And Resilience For Families Affected By Alcoholism Within The Deaf And Hard Of Hearing (Dhh) Community, Jessica Ellen Kuehne

Faculty Publications and Presentations

This presentation will cover research-based information about family alcoholism, children of alcoholics (COA), and adult children of alcoholics (ACOA) and explore how it impacts the Deaf community. Cultural considerations regarding alcohol use will be included in the presentation. The purpose of the workshop is to engage participants in increasing their knowledge and understanding of working with the unique group. It is important to note that the lack of studies and resources focusing on family alcoholism which impacts a group of COAs and ACOAs in the Deaf community. The presentation will begin with a brief overview of how family alcoholism impacts …

Plant-Derived Bioactives, The Gut-Brain Axis, And Neurodegenerative Diseases: Mechanistic Roles Of Diet-Microbiota Interactions, Ashley Reynolds, Ethan Glenn, Brigitte Lavoie, Suzanne L. Ishaq, Yanyan Li

Pharmacy Faculty Scholarship

Diet is increasingly recognized as a potential upstream modulator of the gut-brain axis (GBA) through its effects on the microbiome, microbial metabolites, and host immune and endocrine responses. The GBA is a complex, bidirectional network connecting the gastrointestinal tract and central nervous system, with diet influencing microbial community structure and metabolic output. Plant-based diets, such as Mediterranean and MIND, have been associated with increased production of anti-inflammatory microbial metabolites and improved barrier function, while high calorie/low nutrient diets are often linked to increased immune activation and barrier dysfunction. However, while microbial metabolites, especially short-chain fatty acids, indoles, bile acids, and …

A Political Ecology Of The Orang Rimba's Struggle And Existence In Jambi, Indonesia, Aditya Dipta Anindita, Arya Hadi Dharmawan, Soeryo Adiwibowo, Didik Suharjito

Forest and Society

Since the 1970s, forest conversion in the name of development has encroached upon the living spaces of the Orang Rimba, a forest-dwelling indigenous group in Jambi Province, Indonesia. Some of the forest areas, which serve as the cultural and livelihood foundation for this hunter-gatherer community, have been transformed into transmigrant settlements and oil palm plantations, while the remaining forests were designated as a National Park in 2000. Although they still have access to the national park, many Orang Rimba have built their livelihoods among the oil palm trees—not as owners or workers, but believing that these lands are their ancestral …

Nevada Health And Bioscience Asset Corporation V. State Of Nevada Ex Rel. Department Of Taxation And Nevada Tax Commission, 142 Nev. Adv. Op. (May 28, 2026), Collin Faught

Nevada Supreme Court Summaries

The court held that contracting with a government entity does not prevent an otherwise qualifying charitable organization from receiving a sales and use tax exemption.

Planned Parenthood Mar Monte, Inc. V. State Ex Rel. Office Of The Nevada Attorney General (Civil), 142 Nev. Adv. Op. 40 (May 28, 2026), Charnel Gibson

Nevada Supreme Court Summaries

Nevada’s parental notification abortion statute is likely unconstitutionally vague because it fails to provide physicians with adequate notice of the conduct required and permits arbitrary enforcement.

Maryland Reproductive Freedom And The Full Personhood Of Pregnant People, Margaret E. Johnson

All Faculty Scholarship

Pregnant and birthing people are inappropriately criminalized. Such criminalization is for behavior during their pregnancy that would not otherwise be criminalized, including when there was no harm to the later born baby, and for birth outcomes like miscarriages and still births. Law supports criminalization in part because of the historic legal significance given to fetal “viability” as a demarcation between full personhood rights for pregnant people and the encroachment of fetal “personhood” on those rights. Focusing on Maryland’s new constitutional amendment for reproductive freedom, this essay examines how the new amendment offers promise in restoring the full personhood rights for …

San-Dar Associates V. Palin

All Decisions

In a GCEL holdover proceeding, the court found for the landlord on two grounds of good cause: nonpayment of rent and tenant's repeated refusal to allow access for repairs to water- and fire-damaged floors despite multiple relocation offers. The court held that GCEL nonpayment holdovers do not require a detailed rent accounting in the predicate notice, that GCEL provides no pre-filing opportunity to cure unlike nonpayment proceedings, and that RPL § 235-e[d] does not apply to GCEL holdovers. Tenant's warranty of habitability defenses failed for lack of evidence.

An Ecological Survey Of Algal Species In The Sawyer River, Al-Muthanna Governorate, Iraq, Rasha.H. R. Al-Miawi, Hiafaa A.J. Al-Barakat, Alaa Jabar Mahmoud

Muthanna Medical Journal

Given the global changes in climate, especially the drought conditions Iraq has recently experienced, along with the severe water shortage, this study sought to develop both quantitative and qualitative methods and strategies for phytoplankton (excluding diatoms) as key indicators to protect ecosystems, boost their resilience, and promote sustainability. sites were chosen for the most prominent cities A number of samples were selected from three sites (Al-Dahara region, Al Jarukhi Bridge, Al-Ghanim area), located on the Al-Sawyer River, which is the most important branch of the Euphrates River in the Al-Muthanna Governorate in southern Iraq in 2024 the species that was …

Unbiased Niche Labeling Maps Immune-Excluded Niche In Bone Metastasis, Zhan Xu, Fengshuo Liu, Yunfeng Ding, Tianhong Pan, Yi-Hsuan Wu, Yujiao Han, Jun Liu, Igor L Bado, Weijie Zhang, Ling Wu, Yang Gao, Xiaoxin Hao, Liqun Yu, Xuan Li, David G Edwards, Hilda L Chan, Sergio Aguirre, Michael Warren Dieffenbach, Elina Chen, Siyue Wang, Yichao Shen, Dane Hoffman, Luis Becerra Dominguez, Charlotte Helena Rivas, Xiang Chen, Hai Wang, Yibin Kang, Zbigniew Gugala, Robert L Satcher, Xiang H-F Zhang

Faculty, Staff and Students Publications

Metastatic cancer cell fate is shaped by the local microenvironment niches. To unbiasedly define the cellular and molecular features of metastatic niches, we developed sortase A-based microenvironment niche tagging (SAMENT), which selectively labels cells encountered by cancer cells during metastasis. Applying SAMENT across multiple cancer models and target organs revealed shared niche features, including macrophage enrichment and T cell depletion, alongside marked organ-specific phenotype heterogeneity in niche macrophages. In bone, metastatic niches are enriched for macrophages expressing estrogen receptor alpha (ERα) with active ERα signaling. Conditional deletion of Esr1 in macrophages significantly impaired bone colonization by enabling T cell infiltration. …

Pregnancy Outcomes After In Utero Exposure To Immune Checkpoint Inhibitors, Morgan Bou Zerdan, Bruna Kfoury, Eliane Aoun, Sarah Diane Hmaidan, Roni Nitecki Wilke, Jeffrey A How, Terri L Woodard, Pamela T Soliman, Laurie J Mckenzie

Faculty, Staff and Students Publications

Importance: Immune checkpoint inhibitors (ICIs) have transformed the management of cancers affecting reproductive-age patients, yet their impact on pregnancy outcomes remains incompletely understood. We describe two cases of maternal and fetal outcomes associated with ICI exposure during pregnancy and present a comprehensive literature review.

Methods: A retrospective chart review was conducted at MD Anderson Cancer Center (1 January 2015 to 31 December 2024) to identify patients exposed to ICIs during pregnancy. Clinical data including cancer type, treatment timing, pregnancy course, and maternal and neonatal outcomes were collected. A narrative literature review was also performed using PubMed to identify reported cases …

Development Of A Second-Generation Rarα Selective Antagonist As An Orally Bioavailable, Effective, Safe, And Reversible Male Contraceptive, Rui Shi, Kristen John, Xuan Qin, Ehfazul Haque, Taimeng Liang, Narsihmulu Cheryala, Feng Li, Henry L Wong, Gunda I Georg

Faculty, Staff and Students Publications

We report the design and SAR studies of benzopyran-, benzofuran-, and benzothiophene-derived inhibitors of the retinoic acid receptor alpha (RARα) for male contraception. SAR studies identified critical features influencing activity, such as the optimal positioning of antagonism moieties and substituents, leading to the discovery of (S)-4-(5-(2,8-dimethyl-5-(p-tolyl)-2H-chromen-3-yl)-1H-pyrrol-2-yl)­benzoic acid (compound 23). Compound 23 is a highly potent RARα inhibitor (IC50 = 0.051 nM) with excellent selectivity (>1650-fold over RARβ and >1960-fold over RARγ) and ADMET properties. Compound 23 is orally bioavailable and reduces sperm counts in mice for a full male contraceptive effect …

The 2026 Fifa World Cup: Communicable Disease Risks And Advice For Visitors To Canada, The United States, And Mexico, Alfonso J Rodriguez-Morales, Ivan Arturo Rodríguez-Sabogal, Beatriz Elena Porras-Pedroza, Álvaro A Faccini-Martínez, Daniel Grisales-Nieto, Florencia Escarrá, Pasesa Pascuala Quispe-Torrez, Francisco Javier Membrillo, Tomás Orduna, Susana Lloveras, Tânia S S Chaves, Miguel M Cabada, Cecilia Perret, René Echavarría, Ana F Ribeiro, Melinda Tanabe, Fernando Bazzino, Maximiliano Ramirez, Baruch Diaz, Karen Mirna Loro Morejón, Karen Daly, Reinaldo Rosas, Maria Belen Lopez, Cristina Miranda, Marisa Liliana Fernandez, Yasemin Özsürekçi, Wasin Matsee, Yenddy Carrero, Cristian Biscayart, Sergio Cimerman, Maria L Avila-Aguero, Roberto Debbag, Jose Brea, Alejandro Risquez, Jaime David Acosta-España, Rolando Ulloa-Gutierrez, Carlos Espinal, Carlos N Torres-Martinez, Marta González-Sanz, Aula Abbara, Jill Weatherhead, Mario Masana

Faculty, Staff and Students Publications

No abstract provided.

Icam1high Neutrophils Sculpt Tumor Evolution And Metastasis Through Symbiotic Adhesion And Reverse Migration, Ling Wu, Zhan Xu, Jun Wang, Fengshuo Liu, Yunfeng Ding, Yang Gao, Siyue Wang, Jun Liu, Hilda L Chan, Weiguo Wu, Yi-Hsuan Wu, Liqun Yu, Xiaoxin Hao, Xuan Li, David G Edwards, Cher Sha, Tobie D Lee, Nan Guan, Sergio Aguirre, Luis Becerra-Dominguez, Dane Hoffman, Xiang Chen, Charlotte Helena Rivas, Xiaoyuan G Yan, Igor L Bado, Weijie Zhang, Qian Zhu, Arun Sreekumar, Robert L Satcher, Xiang H-F Zhang

Faculty, Staff and Students Publications

Neutrophils are a prominent component of the tumor microenvironment that can have both pro- and anti-tumor functions. By analyzing neutrophils across different human cancers, we revealed an ICAM1high subset enriched in the tumor microenvironment, which were also observed in murine triple negative breast cancer (TNBC) models. ICAM1high neutrophils exhibited an enhanced capacity for cell-cell adhesion specifically with tumor cells retaining epithelial features, and this adhesion conferred mutual advantages to both cell types. In contrast, cancer cells with mesenchymal-like phenotypes were vulnerable to neutrophil-mediated cytotoxicity due to decreased cell adhesion and elastase resistance. These opposite effects drove tumor evolution toward a …

Panda-Plus-Bench: A Clinical Benchmark For Evaluating The Robustness Of Ai Foundation Models In Prostate Cancer Diagnosis, Joshua L. Ebbert, Dennis Della Corte

Faculty Publications

Artificial intelligence foundation models are increasingly deployed for prostate cancer Gleason grading, where GP3/GP4 distinction directly impacts treatment decisions (active surveillance vs. intervention). However, these models may achieve high validation accuracy by learning specimen-specific artifacts rather than generalizable biological features, limiting real-world clinical utility. We introduce PANDA-PLUS-Bench, a curated benchmark dataset derived from expertly annotated prostate biopsies designed specifically to quantify this failure mode. The benchmark comprises nine carefully selected whole slide images from nine unique patients containing diverse Gleason patterns, with non-overlapping tissue patches extracted at both 512 × 512 and 224 × 224-pixel resolutions across eight augmentation conditions. …

Hypercapnic Respiratory Failure Secondary To Myxedema Coma: A Case Report, Carrine S. Kogulan, Oluwafemi Ajibola

Student Publications

Hypothyroidism affects a large subset of the population, with many undiagnosed. In iodine-sufficient regions, chronic autoimmune thyroiditis (Hashimoto’s) is the leading cause. Chronic, untreated hypothyroidism can result in multisystem complications, including cardiovascular disease, infertility, and respiratory failure. The most severe presentation, myxedema, is a medical emergency marked by altered mentation, ranging from lethargy to coma, hypothermia, and hypoventilation. Prompt recognition and treatment with thyroid hormone replacement are essential to improve outcomes. We present a case of hypercapnic respiratory failure secondary to myxedema coma. A 51-year-old female with morbid obesity (BMI 39.9 kg/m²) presented unresponsive, hypoxemic, and cyanotic, requiring emergent intubation. …

A Review Of Enhanced Recovery After Surgery In Kidney And Liver Transplantation And Outline Of The Newcastle Eras Protocols, E. Bonner, C. Scuffell, F. Dowen, L. Macdougall, J. Fabes

Peninsula Medical School

Although Enhanced Recovery after Surgery (ERAS) is now common practice across various surgical specialties, the adoption of its principles has only recently gained momentum in liver and kidney transplantation. The publication of relevant ERAS guidelines in these specialties has undoubtedly facilitated the assimilation of evidence in support of ERAS components, the paucity of which had been viewed as a barrier to the implementation of ERAS in transplantation. In conjunction, institutionally-developed ERAS pathways have provided pragmatic examples of how these principles can be adopted within transplant practice. In this article, we summarise the current recommendations and underlying evidence for key components …

Applicability Of Diatom Indices And Phytoplankton Functional Groups To Assessment Of Water Quality In The Coastal Egyptian Mediterranean Estuary, Fatma A. Zaghloul, Soha H. Shabaka

Blue Economy

This study provides the first application of diatom-based water quality and eutrophication assessments in Egypt, focusing on the El Mex Bay situated along the Mediterranean Coast of Egypt, providing a comprehensive evaluation of how diatom assemblages can serve as reliable bioindicators for ecological monitoring in this heavily impacted coastal system. It analyzes two distinct periods: monthly from 2003-2004 and seasonally from 2020-2021. Diatom community composition shifted significantly between the two decades. The earlier period hosted 109 diatom species, which declined to 69 species in the later period. Concurrently, overall abundance decreased from 1,071 x 10³ to 728 x 10³ cells/L. …

Seaweed-Derived Bioactives: A Promising Source Of Novel Therapeutics, Aida H. Shobier, Sahar W.M. Hassan, Safaa A. Abdel Ghani

Blue Economy

The marine environment provides bioactive natural products with unique structures that are absent in terrestrial compounds. This review aims to provide a thorough overview of key studies on bioactives derived from seaweeds. It focuses on their potential to address common diseases such as microbial infections, diabetes, oxidative stress, inflammation, viral infections, cancer, immune disorders, and Alzheimer's disease as well as their potential use in drug delivery systems. The bioactive compounds found in seaweeds belong to various chemical classes, with the largest proportion being polysaccharides, lipids, proteins, phenolics, pigments, terpenoids, alkaloids, and sterols. These compounds possess significant pharmacological potential. …

The Applicability Of A Scale On Self-Regulated Writing Strategies In English For High School Students, Teresa Angelina Kaluge, Sisilia Setiawati Halimi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Writing appeared to be crucial in learning foreign languages. This study aimed at examining the applicability of a measure on self-regulated writing strategies in terms of its psychometric properties. The scale items were designed from theoretical foundations and previous relevant studies. Questionnaires were distributed online to high school students, collected and analyzed as many as 106. Correlation, confirmatory factor analyses, and calculating Cronbach’s alpha were carried out to make sure the applicability of the scale. The findings showed five main constructs to be applicable. They were self-initiating, planning, text-generating, revising, and acting on feedback.

Mapping Arabic Calligraphy Education Research Structure: A Bibliometric Analysis Between 2016 And 2021 Using Vosviewer, Nurul Murtadho, Mohammad Dawood

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The purpose of this study is to present a bibliometric analysis of Arabic calligraphy research from the Scopus database from 2016 to 2021. This study identified 43 English documents for further analysis based on the query used and the document screening stages. In this study, Vosviewer was used to visualize the data, and Harzing's Publish or Perish is used to harvest data, calculate metrics, and analyze citations. According to our findings, Arabic calligraphy research publications are increasing, with the peak occurring in 2019, including in terms of citations. The findings indicate that research in language and arts is closely related …

Kesiapan Dan Motivasi Mahasiswa Dalam Mengikuti Pembelajaran Online Di Masa Pandemi Covid-19, Nur Indrianti, Ellen Chung, Ammar Hamid Adil

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aimed to determine online learning readiness, motivation, and challenges for students in Indonesia during the COVID-19 pandemic. Aspects considered in this study included supporting devices and skills to use them, independence in learning, self-control for successful learning, learning motivation, and online communication. The study was conducted using an online questionnaire and crosstabs analysis. The results showed that the students had a good readiness and motivation to do online learning during the pandemic. The most common obstacles included internet connection, limited data quota, unsupported devices, and lecturer learning methods.

Modeling The Impact Of Treatment During An Ongoing Tuberculosis Outbreak, Bach Le, Anna Robicheaux, Jude Shive, Alana Wells, Erin N. Bodine

Spora: A Journal of Biomathematics

In response to a significant tuberculosis outbreak in Wyandotte and Johnson Counties, Kansas, this study presents a compartmental model of ordinary differential equations to evaluate the impact of standard antibiotic treatment. The model incorporates latent, active, and treated disease states. Parameter values were informed by epidemiological data and uncertain parameter value ranges were explored systematically through uncertainty analysis using constrained Latin hypercube sampling. Cumulative infections and deaths, and the basic reproduction number, were computed over a five-year simulation period. Sensitivity analyses using partial rank correlation coefficients identified symptomatic treatment rate and transmission rate as primary drivers of cumulative infections and …

Belonging As The Bedrock Of Learning, Gloria Mcdaniel-Hall, Nina Weisling

i.e.: inquiry in education

The reasons why we teach are intensely personal. We give our hearts and souls to “the work,” though it is so much more than work to us. It is a calling, felt deep in our souls, to correct wrongs, to bend the “arc of the moral universe” all the way to justice, to realize the dreams that have been deferred at best and stamped out and denied at worst. Because at the core of each day, we find humans, students, families, and colleagues who are inherently worthy of learning, loving, and living a fulfilling life. Yet, for far too many …

Living With Ai Within The Context Of Higher Education, Terry Jo Smith

i.e.: inquiry in education

This autoethnographic study examines how generative AI has entered higher education, reshaping teachers’ and students’ inner lives, relational practices, and institutional ecologies. Drawing on the author’s embodied experiences within the higher education landscape, the analysis consists of plugging in theory, research, policy, and current events as a means to connect individual experience with broader concepts, events, and structures (Jackson & Mazzei, 2022). The paper maps affective responses such as awe and anxiety, pedagogical tensions such as assessment, transparency, and trust, and political-economic drivers such as capitalism and policy. The study foregrounds methodological reflexivity, arguing that critical autoethnography can surface situated …

Scaffolded Generative Ai In Instructional Planning: Supporting Teacher Candidates’ Culturally Responsive Teaching, Dr. Eun Kyung Ko, Xiaoning Chen, Vishodana Thamotharan, Julie Sidarous

i.e.: inquiry in education

As generative artificial intelligence (GenAI) becomes increasingly embedded in instructional planning, teacher education programs must move beyond efficiency-oriented adoption toward equity-centered, pedagogically grounded integration. This mixed-methods longitudinal study examines a year-long, scaffolded approach to integrating GenAI within an early childhood teacher residency program, with a specific focus on culturally responsive teaching (CRT) instructional planning. Guided by the AI/I-TPACK and CRT frameworks, fourteen bilingual teacher candidates (TCs) participated in this study. Data sources included pre- and post-surveys of CRT self-efficacy, lesson plans and instructional artifacts, reflective coursework, and focus group interviews. Quantitative analyses revealed statistically significant gains in TCs’ CRT self-efficacy …

Dynamic Gateway Assignment For A Programmable Core In Any-G Networks, Anthony Maswan Fajri, Anders Askerup

Defensive Publications Series

Described herein is a Session Management Function Management Function (SMF-MF) that can provide a unified, intelligent system for optimizing performance across Any-G networks. By leveraging subscriber-level data and real-time network analytics, the SMF-MF can enable AI-driven load balancing and seamless session management while significantly reducing signaling overhead. The disclosed architecture may provide a centralized and future-ready approach to gateway selection that bridges operational differences between Long-Term Evolution (LTE) and Fifth Generation (5G) environments.