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Pacific Islander Mental Health: A Literature Review, Shawn I. Dobberfuhl Jan 2025

Pacific Islander Mental Health: A Literature Review, Shawn I. Dobberfuhl

Modern Psychological Studies

Mental health among Pacific Islanders remains an underexplored area in research. This review aims to synthesize existing research on the mental health status of Pacific Islanders, focusing on mental health risk factors and mental health service utilization. A systematic search across APA PsychInfo spanning from 2015 to 2024 yielded 11 relevant articles, which were subsequently analyzed and synthesized. Findings suggest that Pacific Islanders experience unique stressors, including, racial discrimination, socioeconomic disparities, and cultural stigma surrounding mental health. However, there is a disparity in culturally sensitive assessment tools and interventions tailored specifically to this population. Future research should prioritize phenomenological methods, …


Is My Parent Narcissistic? Retrospective Perceptions Of The Adult Child On Their Parent’S Narcissistic Tendencies, Amy Palumbo, Ashley Hansen-Brown Dr. Jan 2025

Is My Parent Narcissistic? Retrospective Perceptions Of The Adult Child On Their Parent’S Narcissistic Tendencies, Amy Palumbo, Ashley Hansen-Brown Dr.

Modern Psychological Studies

Narcissism development in children has been a widely studied subject; however, little research has examined parental narcissism. Previous researchers found that parental narcissism is related to non-ideal parent-child bonds, which often results in parents having low senses of well-being and satisfaction with their bond (Hart et al., 2017; Horton, 2021). For each of our studies, we explored how aspects of an individual’s growth and development are linked with parental narcissism as recalled by adult children. In Study 1, we investigated the link between both recalled grandiose and vulnerable parental narcissism and the mental well-being and self-esteem of our participants. In …


Study Of The Relationship Between Interoceptive Sensibility And Distress Tolerance In Community And College Samples, William W. Moore, Ashley Howell Jan 2025

Study Of The Relationship Between Interoceptive Sensibility And Distress Tolerance In Community And College Samples, William W. Moore, Ashley Howell

Modern Psychological Studies

Interoceptive sensibility involves the detection, integration, and interpretation of internal bodily signals, primarily from cardiovascular, pulmonary, or gastrointestinal systems. Dysfunction in interoceptive processing has been increasingly recognized as a clinically relevant factor in numerous neurological, psychiatric, and behavioral disorders. This study aimed to elucidate the relationship between interoceptive sensibility and distress tolerance, hypothesizing that individuals with heightened interoceptive sensibility may report poorer distress tolerance. This relationship could help identify patterns between interoceptive sensibility and tendencies toward maladaptive coping strategies or emotional dysregulation. To explore these relationships, two studies were conducted utilizing self-report measures of interoceptive sensibility and distress tolerance in …


Born To Be Kind: The Evolutionary Significance Of Prosocial Behaviors In Humans, Yijia Xu Jan 2025

Born To Be Kind: The Evolutionary Significance Of Prosocial Behaviors In Humans, Yijia Xu

Modern Psychological Studies

Humans prefer kind romantic partners. Worldwide surveys have identified kindness as the defining feature of an ideal long-term partner, often explained as a signal for evolutionary fitness, demonstrating the ability to provide resources and ensure survival. Instead, we propose an alternative explanation: human preference for prosociality stems from an innate desire to be treated well. To test this, we asked participants whether they preferred kindness directed towards them or kindness exhibited more generally. Results indicate that participants were significantly more attracted to people who were kind to them personally than to people who were broadly kind to others. Interestingly, participants …


Escapism: The Presence Of Escapist Tendencies In Depressed Gamers, Hannah K. Weberg, Emily Pica Jan 2025

Escapism: The Presence Of Escapist Tendencies In Depressed Gamers, Hannah K. Weberg, Emily Pica

Modern Psychological Studies

Escapism, a coping mechanism used to relieve stress, uniquely characterized by removing one’s conscious self from reality, can be utilized by video gamers with depression to escape from their own realities. The implications of this phenomenon could allow researchers to better understand how escapism affects this community. It was predicted that there would be a positive relationship between escapist gaming motivations and depressive symptoms. Using a combination of quantitative and qualitative survey methods drawing from undergraduate students at Austin Peay State University (n = 113) and correlational analyses, our hypotheses were supported. A significant positive relationship was found between escapist …


The Influence Of Media Exposure On Perceptions Of Police, Izabella Leblanc, Emily Pica Jan 2025

The Influence Of Media Exposure On Perceptions Of Police, Izabella Leblanc, Emily Pica

Modern Psychological Studies

The current literature suggests that People of Color (POC) often hold more negative perceptions of law enforcement compared to White individuals. These perceptions are influenced by various factors, including environment, exposure to media depictions of police brutality, and personal experiences. Since flawed portrayals of police procedures in television programs have been found to erode public trust in police legitimacy, the study analyzes how perceptions change through media portrayals of law enforcement interactions. We investigate how the media influences perceptions of law enforcement by presenting participants (n = 245) with mock news articles depicting various law enforcement interactions. Additionally, we consider …


Pathways To Lgbtq+ Self-Acceptance: A Qualitative Study Of Religious, Spiritual, And Mystical Experiences, Makayla Hall, Ruth Walker Jan 2025

Pathways To Lgbtq+ Self-Acceptance: A Qualitative Study Of Religious, Spiritual, And Mystical Experiences, Makayla Hall, Ruth Walker

Modern Psychological Studies

For the LGBTQ+ community, self-acceptance often involves embracing one’s identity while confronting internalized stigma, hardships, and religious or societal pressures (Lassiter et al., 2019; Schuck & Liddle, 2001; Stern & Wright, 2017). Prior researchers have highlighted both positive and negative effects of religious and spiritual beliefs for LGBTQ+ individuals, with spirituality often fostering resilience and social support (Lassiter et al., 2019) and religious institutions sometimes contributing to feelings of alienation (Schuck & Liddle, 2001). The purpose of this study was to explore how religious, spiritual, and mystical experiences influence self-acceptance in LGBTQ+ adults. We used reflexive thematic analysis to explore …


Implementing A Care Progression Model Aimed At Improving Quality Outcomes, Jaclyn Rowbotham Msn, Rn, Acm-Rn Jan 2025

Implementing A Care Progression Model Aimed At Improving Quality Outcomes, Jaclyn Rowbotham Msn, Rn, Acm-Rn

Patient Care Services / Nursing

No abstract provided.


Reduction Of Wrong Blood In Tube Events: Improving Practice One Tube At A Time, Amy Taff Msn, Rn, Ni-Bc Jan 2025

Reduction Of Wrong Blood In Tube Events: Improving Practice One Tube At A Time, Amy Taff Msn, Rn, Ni-Bc

Patient Care Services / Nursing

No abstract provided.


Wellness And The Tax Law, Leigh Z. Osofsky Jan 2025

Wellness And The Tax Law, Leigh Z. Osofsky

Georgia Law Review

The tax law has long provided extensive subsidies for “medical care.” These subsidies cost the government hundreds of billions of dollars a year. The definition of medical care, which is at the heart of these subsidies, originated many decades ago at a time when there was little to no conception of wellness.

Times have changed in the medical world. Medical science now emphasizes that wellness practices, like exercise, meditation, and social connection, have an important impact on physical as well as mental health, including by playing a significant role in preventing and treating disease. Under the tax statute, medical care …


Surveillance As Retaliation, Daiquiri J. Steele Jan 2025

Surveillance As Retaliation, Daiquiri J. Steele

Georgia Law Review

Employers have a myriad of technologies at their disposal to help them surveil their employees, and they deploy these technologies for several reasons. Some of these reasons—e.g., monitoring time and attendance, ensuring compliance with occupational safety standards, protecting against certain data disclosure, etc.—are legitimate. Others are not. Chief among the illegitimate reasons is monitoring employees in retaliation for reporting alleged employer misconduct internally or externally. Just as terminating, demoting, or transferring an employee constitutes an adverse action for retaliation claims, subjecting an employee to surveillance because the employee has engaged in protected activity is also an adverse action. Courts and …


Public Constitutional Ai, Gilad Abiri Jan 2025

Public Constitutional Ai, Gilad Abiri

Georgia Law Review

We are increasingly subjected to the power of AI authorities. Machine learning models now underpin algorithmic markets, determine whose speech is amplified or restricted, shape government decisions ranging from resource allocation to predictive policing, and influence our access to information on critical issues such as voting and public health. As AI decisions become inescapable, entering domains such as healthcare, education, and law, we must confront a vital question: How can we ensure that AI systems, which increasingly regulate our lives and make decisions that shape our societies, have the authority and legitimacy necessary for effective governance?

To secure AI legitimacy, …


On Parentage, Genetics, And Surrogacy, Jessica Tueller Jan 2025

On Parentage, Genetics, And Surrogacy, Jessica Tueller

Georgia Law Review

Bans in some jurisdictions, combined with relative affordability in others, have turned surrogacy into an increasingly cross-border phenomenon. Meanwhile, the complex and varied approaches to legal parentage and surrogacy that exist in domestic jurisdictions, along with a lack of international oversight, have at times left children of surrogacy parentless or stateless. The decision of the Hague Conference on Private International Law to begin regulating legal parentage in international surrogacy arrangements is thus an important and welcome development. However, the Hague Conference is considering imposing new genetic requirements that could result in violations of the rights to equality and non-discrimination of …


Jones V. Mississippi: Sweeping Away The Due Process Protections Of Juvenile Offenders, Tiffani N. Darden Jan 2025

Jones V. Mississippi: Sweeping Away The Due Process Protections Of Juvenile Offenders, Tiffani N. Darden

Georgia Law Review

The U.S. Supreme Court’s pronouncement in Jones v. Mississippi raises questions about whether states will adequately adhere to the fundamental fairness principles of constitutional due process. The current juvenile sentencing procedures center on Miller v. Alabama, in which the Court struck down mandatory life-without-parole statutes applicable to juveniles. But in the post-Miller era, state legislatures and courts have struggled with how to apply the Miller Court’s holding. Ultimately, the Jones Court eliminated procedural due process rights for the criminal system’s most vulnerable class. But while procedural due process in the criminal sentencing context is not well defined as …


Federalizing Ncii Regulation: The Take It Down Act’S Approach To Criminalization, Platform Liability, And Threats To Disseminate, Trudi K. Sundberg Jan 2025

Federalizing Ncii Regulation: The Take It Down Act’S Approach To Criminalization, Platform Liability, And Threats To Disseminate, Trudi K. Sundberg

Georgia Law Review

For years, legal scholars, advocates, and victims have pushed for the federal criminalization of the nonconsensual publication of intimate imagery. Until now, regulation has been inconsistent across jurisdictions, often leaving victims without meaningful remedies or mechanisms for image removal.

The recent passage of the Take It Down Act has finally realized the goal of federal criminalization of nonconsensual intimate image distribution, including that of artificially generated images. The Act further initiates a framework for victim-led takedown procedures and engages with § 230 liability. Additionally, the Act addresses threats to disseminate such content, which is crucial to curb the spread of …


State Constitutional Rights To Privacy, Tiffany C. Li Jan 2025

State Constitutional Rights To Privacy, Tiffany C. Li

Georgia Law Review

This article examines state constitutional rights to privacy, presenting a comprehensive survey of all states that have explicit rights to privacy enumerated in their constitutions. Understanding state constitutional rights to privacy is particularly critical now in the wake of the 2022 U.S. Supreme Court decision Dobbs v. Jackson Women’s Health Organization, which significantly restricted the scope of federal constitutional privacy rights. As states have the authority to independently interpret their constitutions, state constitutional law may provide a path forward for privacy.

In lieu of relying on federal rights protection, individuals may now need to turn to state constitutional rights …


State Constitutional Development And The Criminal Procedure Revolution, Quinn Yeargain Jan 2025

State Constitutional Development And The Criminal Procedure Revolution, Quinn Yeargain

Georgia Law Review

Questions about which rights, liberties, and guarantees are included in the U.S. Constitution’s protections, and how they are protected, have long produced animated debate among scholars, judges, and advocates. Yet, while today’s debates may seem familiar, they take place at a perilous time in our country’s trajectory. We are six decades removed from the Warren Court’s criminal procedure revolution, and just a few years into the Roberts Court’s full-throated embrace of originalist jurisprudence. Whether many of the protections we have come to know and recognize from the Warren Court—the exclusionary rule, Miranda warnings, and Gideon’s mandate—are subjected to re-evaluation …


A Governor's Duty To Ask, Jake Mazeitis Jan 2025

A Governor's Duty To Ask, Jake Mazeitis

Georgia Law Review

As some federal constitutional protections contract, state constitutions are becoming an increasingly important source of individual rights. But state constitutional development involves either amendment or litigation, processes both slow and costly. Ten states offer a third path: They empower governors to request advisory opinions from their supreme courts. These governors, however, have rarely exercised this power.

This article argues that a governor’s refusal to seek such advice violates the constitutional duty to faithfully execute the law; specifically, the law respecting the separation of powers. Drawing on an empirical analysis, I first show that governors are generally shy to ask for …


Integrative Genomic And Transcriptomic Analysis Reveals Targetable Vulnerabilities In Angioimmunoblastic T-Cell Lymphoma, Alyssa Bouska, Weiwei Zhang, Sunandini Sharma, Harald Holte, Rauf Shah, Waseem G. Lone, Mahfuza Afroz Soma, Ruimeng Yang, Xuxiang Liu, Syed Mehmood, Ravneet Singh Chawla, Luca Vincenzo Cappelli, Danilo Fiore, Qiang Gong, Tayla B. Heavican-Foral, Jeffrey J. Cannatella, Catalina Amador, Aiza Arif, Lynette M. Smith, Soon Thye Lim, Choon Kiat Ong, Andrew L. Feldman, Ming-Qing Du, Anamarija M. Perry, Laurence De Leval, Timothy C. Greiner, Kai Fu, Gunhild Trøen, Daniel Vodák, Sigve Nakken, Jan Delabie, David Weinstock, Stefano Pileri, Antonella Laginestra, Kyeongjin Kim, Utpal Pajvani, Julie M. Vose, Dennis D. Weisenburger, Steven M. Horwitz, Sandeep Dave, Joseph Khoury, Giorgio Inghirami, Wing C. Chan, Javeed Iqbal Jan 2025

Integrative Genomic And Transcriptomic Analysis Reveals Targetable Vulnerabilities In Angioimmunoblastic T-Cell Lymphoma, Alyssa Bouska, Weiwei Zhang, Sunandini Sharma, Harald Holte, Rauf Shah, Waseem G. Lone, Mahfuza Afroz Soma, Ruimeng Yang, Xuxiang Liu, Syed Mehmood, Ravneet Singh Chawla, Luca Vincenzo Cappelli, Danilo Fiore, Qiang Gong, Tayla B. Heavican-Foral, Jeffrey J. Cannatella, Catalina Amador, Aiza Arif, Lynette M. Smith, Soon Thye Lim, Choon Kiat Ong, Andrew L. Feldman, Ming-Qing Du, Anamarija M. Perry, Laurence De Leval, Timothy C. Greiner, Kai Fu, Gunhild Trøen, Daniel Vodák, Sigve Nakken, Jan Delabie, David Weinstock, Stefano Pileri, Antonella Laginestra, Kyeongjin Kim, Utpal Pajvani, Julie M. Vose, Dennis D. Weisenburger, Steven M. Horwitz, Sandeep Dave, Joseph Khoury, Giorgio Inghirami, Wing C. Chan, Javeed Iqbal

Journal Articles: Oncology and Hematology

Nodal follicular helper T-cell (TFH) lymphoma of the angioimmunoblastic (AITL) subtype has a dismal prognosis. Using whole-exome sequencing (n = 124), transcriptomic (n = 78), and methylation (n = 40) analysis, we identified recurrent mutations in known epigenetic drivers (TET2, DNMT3A, IDH2R172) and novel ones (TET3, KMT2D). TET2, IDH2R172, DNMT3A co-mutated AITLs had poor prognosis (p < 0.0001). Genes regulating T-cell receptor (TCR) signaling (CD28, PLCG1, VAV1, FYN) or activation (RHOAG17V) or regulators of the PI3K-pathway (PIK(3)C members, PTEN, PHLPP1, PHLPP2) were mutated. CD28 mutation/fusion was associated with poor prognosis (p = 0.02). WES of purified, neoplastic T-cell (CD3+PD1+) demonstrated high concordance with …


Cooperative Role Of Distinctive Tp53 And Pten Combined Loss In The Peripheral T Cell Lymphoma-Gata3 Molecular Subgroup, Waseem G. Lone, Jiayu Yu, Xuxiang Liu, Dylan T. Jochum, Alyssa Bouska, Kunal Shetty, Tyler Herek, Sunandini Sharma, Chengfeng Bi, Rauf Shah, Zaina W. Nasser, Catalina Amador, Aiza Arif, Abdul Rouf Mir, Yuping Li, Tayla B. Heavican-Foral, Jacob Robinson, R. Katherine Hyde, Mamiko Sakata-Yanagimoto, Satyanarayana Rachagani, Timothy W. Mckeithan, David W. Scott, Louis M. Staudt, Giorgio Inghirami, Andrew Feldman, Timothy Greiner, Julie M. Vose, Lisa Rimsza, Joseph Khoury, Wing C. Chan, Javeed Iqbal, Lymphoma/Leukemia Molecular Profiling Project (Llmpp) Jan 2025

Cooperative Role Of Distinctive Tp53 And Pten Combined Loss In The Peripheral T Cell Lymphoma-Gata3 Molecular Subgroup, Waseem G. Lone, Jiayu Yu, Xuxiang Liu, Dylan T. Jochum, Alyssa Bouska, Kunal Shetty, Tyler Herek, Sunandini Sharma, Chengfeng Bi, Rauf Shah, Zaina W. Nasser, Catalina Amador, Aiza Arif, Abdul Rouf Mir, Yuping Li, Tayla B. Heavican-Foral, Jacob Robinson, R. Katherine Hyde, Mamiko Sakata-Yanagimoto, Satyanarayana Rachagani, Timothy W. Mckeithan, David W. Scott, Louis M. Staudt, Giorgio Inghirami, Andrew Feldman, Timothy Greiner, Julie M. Vose, Lisa Rimsza, Joseph Khoury, Wing C. Chan, Javeed Iqbal, Lymphoma/Leukemia Molecular Profiling Project (Llmpp)

Journal Articles: Oncology and Hematology

Peripheral T cell lymphoma (PTCL) is a heterogeneous group of postthymic T cell neoplasms, with ~40% classified as PTCL-not otherwise specified (PTCL-NOS). PTCL-GATA3, a molecularly defined subtype, associated with T helper 2 (TH2)-like differentiation and poor prognosis, has frequent co-occurrence of TP53 loss/mutation and heterozygous PTEN loss. CD4+ T cell conditional mouse models with Trp53 mutation/deletion and Pten loss demonstrated mature T cell lymphomas (mTCLs) with TH2-like transcriptomic and immunophenotypic profiles. Molecular studies revealed that codeletion of Trp53/Pten induced T cell receptor and Janus kinase-signal transducer and activator of transcription signaling, promoting TH2 differentiation …


Impact Of Tranexamic Acid On Patient Outcomes In Intracranial Hemorrhage: A Review, William G. Johnson Jan 2025

Impact Of Tranexamic Acid On Patient Outcomes In Intracranial Hemorrhage: A Review, William G. Johnson

The PA Department Journal of Medical Science

Introduction: Intracranial hemorrhage is a medical emergency that remains a significant source of death and disability for patients globally. Tranexamic acid has shown promise in treating trauma related bleeding loss in various settings. This study aims to evaluate its role in the management of intracranial hemorrhages.

Methods: A review of data in the PubMed National Library of Medicine was conducted to find relevant and reputable studies related to this topic. Using the search “tranexamic acid AND intracranial hemorrhage*” and the following filters: last 5 years, free full text, English language, including RCTs, meta-analyses, and systematic reviews, 13 results …


Efficacy Of Ultrasound To Detect Rotator Cuff Tears, Hunter Morrison Jan 2025

Efficacy Of Ultrasound To Detect Rotator Cuff Tears, Hunter Morrison

The PA Department Journal of Medical Science

Introduction: Rotator cuff injury is the most common cause of shoulder pain in the world, and there are a few different imaging techniques that can be used to help with their diagnosis. The purpose of this review is to determine the efficacy of ultrasound, an available and cost-effective option, to detect rotator cuff tears.

Methods: PubMed was searched for studies and meta-analyses that compared ultrasound to other imaging modalities and their ability to detect rotator cuff tears.

Results: One meta-analysis and 4 clinical research studies revealed that ultrasound has variable diagnostic accuracy compared to MRI depending on the RCT tendon, …


In Patients With Submassive Pulmonary Embolism, Does Catheter Direct Thrombolysis Reduce Mortality Compared To Anticoagulation, Melky Perez Jan 2025

In Patients With Submassive Pulmonary Embolism, Does Catheter Direct Thrombolysis Reduce Mortality Compared To Anticoagulation, Melky Perez

The PA Department Journal of Medical Science

Introduction: PE is a life-threatening condition leading to obstructed blood flow and compromised gas exchange. Prompt recognition and treatment are crucial to improving outcomes and reducing mortality, particularly in patients with submassive PE. This paper evaluates the effectiveness of catheter-directed thrombolysis (CDT) in enhancing treatment protocols for PE compared to standard anticoagulation.

Methods: A literature review was conducted using the PubMed database, focusing on articles related to pulmonary embolism, anticoagulation, and catheter thrombolysis from 2019 to 2024. The search, refined by MeSH terms and Boolean operators, yielded 192 results, narrowed down to 16 relevant randomized control trials, meta-analyses, and systematic …


Reduced Risk Of Necrotizing Enterocolitis With Breastfeeding, Jadyn Tavekelian Jan 2025

Reduced Risk Of Necrotizing Enterocolitis With Breastfeeding, Jadyn Tavekelian

The PA Department Journal of Medical Science

Abstract

Introduction: Necrotizing enterocolitis (NEC) is a life-threatening disease in infants that causes direct damage to the intestines and requires emergent treatment. The purpose of this clinical review is to analyze the prevention of NEC in preterm neonates with breastfeeding.

Methods: PubMed was searched using a specific search strategy using the key terms “breast,” “feed,” “formula,” “necrotizing,” and “enterocolitis.” Operators and filters applied narrowed the results to 4 quality articles for review.

Results: One RCT, and two meta-analyses, reviewed had a reduction in the development of necrotizing enterocolitis among breastfed neonates. One randomized noninferiority trial totaling 123 neonates did not …


Efficacy Of Second Generation Antipsychotics As An Adjunct Therapy For Major Depressive Disorder, Gina Russo Jan 2025

Efficacy Of Second Generation Antipsychotics As An Adjunct Therapy For Major Depressive Disorder, Gina Russo

The PA Department Journal of Medical Science

INTRODUCTION: Major depressive disorder is a debilitating mental health condition for many US adults. Traditional therapies may not be effective for many patients. The purpose of this paper is to evaluate the effectiveness of brexpiprazole, a second generation antipsychotic medication, as an adjunctive treatment for resistant MDD.

METHODS: PubMed was searched with a specific search strategy using key terms “brexpiprazole” and “major depressive disorder.” This search resulted in 21 results in which four articles were chosen based on the availability of free full text and the included content. Of the articles selected, three were a systemic review and meta-analyses, …


Efficacy Of Low-Level Laser Therapy For Osteoarthritis Of The Knee, Emily Drummond Jan 2025

Efficacy Of Low-Level Laser Therapy For Osteoarthritis Of The Knee, Emily Drummond

The PA Department Journal of Medical Science

Introduction: Osteoarthritis (OA) is a disease associated with numerous effects on quality of life (QoL) and activities of daily living (ADLs). In recent years, low-level laser therapy (LLLT) has been evaluated as a symptom management option for KOA due to its non-invasive mechanistic properties. The purpose of this paper is to assess the efficacy of LLLT as a modality of treatment to help reduce mild to moderate symptoms associated with KOA.

Methods: A search via PubMed database was made using the keywords “LLLT” AND “osteoarthritis” AND “knee” with additional specifiers resulting in 10 articles for review. Four articles were chosen …


Buprenorphine As An Adjunctive Therapy For Pain Management In Opiate Use Disorder, Zane Hogston Jan 2025

Buprenorphine As An Adjunctive Therapy For Pain Management In Opiate Use Disorder, Zane Hogston

The PA Department Journal of Medical Science

Introduction: Buprenorphine, a partial opioid agonist, has gained significant attention for its potential to address both opioid use disorder (OUD) and pain management. Offering an alternative to traditional opioids, buprenorphine is seen as a promising option, particularly for patients with a history of opioid misuse. Despite its increasing use in treating OUD, the evidence supporting its effectiveness in pain management remains limited, especially among broader patient populations. This review aims to explore current research findings and highlight buprenorphine’s role in managing pain among individuals with OUD.

Methods: A comprehensive search of PubMed was conducted using keywords such as “pain,” “buprenorphine,” …


The Impact Of Proton Pump Inhibitors On Cardiovascular And Bleeding Outcomes In Coronary Heart Disease Patients Undergoing Percutaneous Coronary Intervention, Melanie R. Stelling Jan 2025

The Impact Of Proton Pump Inhibitors On Cardiovascular And Bleeding Outcomes In Coronary Heart Disease Patients Undergoing Percutaneous Coronary Intervention, Melanie R. Stelling

The PA Department Journal of Medical Science

Introduction: Coronary heart disease (CHD) is a leading cause of mortality worldwide, with percutaneous coronary intervention (PCI) as the primary therapeutic approach. This review evaluates the effect of proton pump inhibitors (PPIs) on gastrointestinal (GI) bleeding risks and cardiovascular outcomes in patients with CHD who are undergoing PCI.

Methods: A systematic search using the PubMed database was conducted. Included in the search terms were: “dual antiplatelet therapy,” “proton pump inhibitors,” “percutaneous coronary intervention,” and “clopidogrel.” The search was narrowed down to include only systematic reviews, meta-analyses, and randomized control trials (RCTs) that were published in English within the last 10 …


Efficacy Of Collagenase Injection In Dupuytren’S Contracture, Janson Witcher Jan 2025

Efficacy Of Collagenase Injection In Dupuytren’S Contracture, Janson Witcher

The PA Department Journal of Medical Science

Introduction: Dupuytren's contracture is a debilitating hand condition characterized by progressive contracture of the palmar fascia. The use of collagenase clostridium histolyticum injections has emerged as a minimally invasive alternative to surgical interventions, with varying degrees of efficacy and safety compared to traditional methods like limited fasciectomy and percutaneous needle fasciotomy.

Methods: A comprehensive literature review was conducted using PubMed to assess the efficacy and safety of collagenase injections for treating Dupuytren's contracture. The search focused on peer-reviewed randomized controlled trials, systematic reviews, and meta-analyses published in the last five years. Five relevant studies were selected based on the robustness …


Cardiovascular Event Reduction In Adults With Hypertension: Comparing Arbs And Other Antihypertensive Medications, Anna Macaluso Jan 2025

Cardiovascular Event Reduction In Adults With Hypertension: Comparing Arbs And Other Antihypertensive Medications, Anna Macaluso

The PA Department Journal of Medical Science

Introduction: Hypertension is a leading cause of heart disease and stroke worldwide. There are various medications available for effective management of hypertension. This paper aims to evaluate the efficacy of antihypertensive medications on cardiovascular events in adults with hypertension, explicitly investigating angiotensin II receptor blockers (ARBs).

Methods: PubMed was searched with filters using key terms “angiot*” AND “hypertens*” AND “antihyp*” and key terms "arb" AND "hyper*" AND "cardiovasc*" to identify articles underlining the efficacy of ARBs and other antihypertensives in the reduction of cardiovascular events in adults with hypertension. Four articles, chosen by their direct comparison of antihypertensive medications and …