Digital Commons Network^™

Resisting Ableism In Research Design, Gipsy Hosking

The Qualitative Report

This paper explores how ableist assumptions can unintentionally create barriers to participation in research by those of non-normative bodies or minds. In traditional epistemology, bodies are considered “universal” rather than “specific,” and the universal body is coded as fully able-bodied and independent with brain and body adhering to normative standards of the White heterosexual English-speaking male. In this article, I present a story of “enabling participation” for those of diverse body capacity in my work with young women living with chronic illness.^[1]Specifically, I explore the accommodations and adaptions I made to my research design to account for the …

Quantitative Approaches To Unravel The Mechanobiology Of Cortical Folding, Ramin Balouchzadeh

McKelvey School of Engineering Graduate Student Theses & Dissertations

Quantitative Approaches to Unravel the Mechanobiology of Cortical Folding by Ramin Balouchzadeh Doctor of Philosophy in Mechanical Engineering Washington University in St. Louis, 2024 Professor Philip V. Bayly, Chair Professor Kara E. Garcia, Co-Chair Brain development is a highly complex process driven by mechanical forces and material properties that shape the cerebral cortex’s characteristic gyri and sulci. Abnormalities in this folding pro?cess are associated with neurodevelopmental disorders such as autism and schizophrenia. Despite significant advancements, the underlying mechanical principles governing brain morphogenesis remain incompletely understood. This body of work investigates three key aspects of brain de?velopment: stress-dependent growth, evolving tissue …

Investigating The Role Of The I-Ii Linker In Nav1.5, Emily Wagner

McKelvey School of Engineering Graduate Student Theses & Dissertations

The cardiac voltage-gated sodium channel, Nav1.5 is essential for initiating the cardiac action potential. Its dysfunction can lead to dangerous arrhythmias, sudden cardiac arrest, and death. Like many channels, its known properties depend heavily on its structure. The functional core of the alpha subunit consists of four homologous repeats (I, II, III, and IV), each formed from a voltage sensing domain and a pore domain. The channel also contains two cytoplasmic termini and three cytoplasmic linkers (I-II, II-III, and III-IV). While most of the channel has been resolved in multiple structures, the I-II and II-III linkers have remained conspicuously absent …

Investigating The Role Of The I-Ii Linker In Nav1.5, Emily Wagner

McKelvey School of Engineering Graduate Student Theses & Dissertations

The cardiac voltage-gated sodium channel, Nav1.5 is essential for initiating the cardiac action potential. Its dysfunction can lead to dangerous arrhythmias, sudden cardiac arrest, and death. Like many channels, its known properties depend heavily on its structure. The functional core of the alpha subunit consists of four homologous repeats (I, II, III, and IV), each formed from a voltage sensing domain and a pore domain. The channel also contains two cytoplasmic termini and three cytoplasmic linkers (I-II, II-III, and III-IV). While most of the channel has been resolved in multiple structures, the I-II and II-III linkers have remained conspicuously absent …

Butte Priority Soils Operable Unit Sbcca Principles For A Greener Cleanup Report, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Butte Priority Soils Operable Unit (Bpsou) Final Bpsou Insufficiently Reclaimed Sites Belle Of Butte (Bres No. 8 & Ur-39) Remedial Action Work Plan (Rawp) Request For Change Ir- 2024-Ra-02, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Editorial: Artificial Intelligence For Smart Health: Learning, Simulation, And Optimization, Bing Yao, Nathan Gaw, Hyo Kyung Lee

Faculty Publications

With rapid developments in medical sensing and imaging, we now live in an era of data explosion in which large amounts of data are readily available in clinical environments. The fast-growing biomedical and healthcare data provide unprecedented opportunities for data-driven scientific knowledge discovery and clinical decision support. Our Research Topic aims to catalyze synergies among biomedical informatics, machine learning, computer simulation, operations research, systems engineering, and other related fields with three specific goals: (1) develop cutting-edge data-driven models to accelerate scientific knowledge discovery in biomedicine using healthcare data collected from laboratory systems, imaging systems, and medical and sensing devices; (2) …

A Phase 1 Randomized Trial Of Homologous And Heterologous Filovirus Vaccines With A Late Booster Dose, Christina A Rostad, Carol Kao, Et Al.

2020-Current year OA Pubs

Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe viral hemorrhagic fever and death. Developing vaccines that provide durable, broad immunity against multiple filoviruses is a high global health priority. In this Phase 1 trial, we enrolled 60 healthy U.S. adults and evaluated the safety, reactogenicity and immunogenicity of homologous and heterologous MVA-BN®-Filo and Ad26.ZEBOV prime-boost schedules followed in select arms by MVA-BN®-Filo boost at 1 year (NCT02891980). We found that all vaccine regimens had acceptable safety and reactogenicity. The heterologous prime-boost strategy elicited superior Ebola binding and neutralizing antibody, antibody-dependent cellular cytotoxicity …

Revisiting Insider Practices: Ethical Considerations, Practices, And Hopes For Doing Community Work And Narrative Research In And About Our Own Communities, Tiffany Sostar, Nathan Viktor Fawaz, Elliot Trimble, Theodosia Octavia Markarian, Bekett Noble

The Qualitative Report

In this paper, we describe the hopes, considerations, and questions of a narrative practice research collaboration among three closely connected transgender (trans) and/or non-binary collaborators, in a collection of work meant to support trans, non-binary, and gender expansive life and in response to trans death at a time of increasing hostility toward trans communities. We apply a specific focus on inquiring into how to do narrative therapy and community work research in and about our own communities, and what the ethical, relational and methodological practices for this work might be. We do this through reflecting on existing literature related to …

Thriving Hives: Cleaning And Sterilizing Beekeeping Equipment, Brynn Meredith, Bailey Parkinson, Andree' Walker Bravo

All Current Publications

Honeybees are susceptible to many types of diseases and parasites, most of which can spread easily through equipment. Your hives' health and safety depend on your attention to detail and efforts to keep your equipment clean and sterile. This fact sheet lists several methods for sterilizing beekeeping equipment. The list is not exhaustive but includes some of the most cost-effective options.

Measurement Of Breast Artery Calcification Using An Artificial Intelligence Detection Model And Its Association With Major Adverse Cardiovascular Events, Suzanne Rose, Josette Hartnett, Zachary Estep, Daniyal Ameen, Shweta Karki, Edward Schuster, Rebecca Newman, David Hsi

Department of Medicine Faculty Papers

Breast artery calcification (BAC) obtained from standard mammographic images is currently under evaluation to stratify risk of major adverse cardiovascular events in women. Measuring BAC using artificial intelligence (AI) technology, we aimed to determine the relationship between BAC and coronary artery calcification (CAC) severity with Major Adverse Cardiac Events (MACE). This retrospective study included women who underwent chest computed tomography (CT) within one year of mammography. T-test assessed the associations between MACE and variables of interest (BAC versus MACE, CAC versus MACE). Risk differences were calculated to capture the difference in observed risk and reference groups. Chi-square tests and/or Fisher's …

The Role Of The Triglyceride-Glucose Index As A Biomarker Of Cardio-Metabolic Syndromes, Verena Gounden, Sridevi Devaraj, Ishwarlal Jialal

Faculty, Staff and Students Publications

BACKGROUND: The Triglyceride-glucose (TyG) index represents a simple, cost-effective, and valid proxy for insulin resistance. This surrogate marker has also been proposed as a predictor of metabolic and cardiovascular disease (CVD). In this descriptive review, we aimed to assess the utility of the TyG index as a predictive biomarker of cardiometabolic diseases.

METHODS: A search was conducted in PubMed, and Web of Science to identify cross-sectional and more importantly prospective studies examining the use of the TyG index as a predictive biomarker. The following terms were utilized in addition to the TyG index: "insulin resistance", "metabolic syndrome", "diabetes"; "cardiovascular diseases". …

Global Prevalence Of Helicobacter Pylori Antibiotic Resistance Among Children In The World Health Organization Regions Between 2000 And 2023: A Systematic Review And Meta-Analysis, Aryan Salahi-Niri, Ali Nabavi-Rad, Tanya Marie Monaghan, Theodore Rokkas, Michael Doulberis, Amir Sadeghi, Mohammad Reza Zali, Yoshio Yamaoka, Evelina Tacconelli, Abbas Yadegar

Faculty, Staff and Students Publications

Background: Helicobacter pylori infection causes gastritis, peptic ulcers, and gastric cancer. The infection is typically acquired in childhood and persists throughout life. The major impediment to successful therapy is antibiotic resistance. This systematic review and meta-analysis aimed to comprehensively assess the global prevalence of antibiotic resistance in pediatric H. pylori infection.

Methods: We performed a systematic search of publication databases that assessed H. pylori resistance rates to clarithromycin, metronidazole, levofloxacin, amoxicillin, and tetracycline in children. The WHO region classification was used to group pooled primary and secondary resistance estimates along with 95% confidence interval (CI). H. pylori antibiotic resistance rates …

Use Of Cigarettes And E-Cigarettes, Impulsivity, And Anxiety: Influences On Suicidal Ideation Among Youth And Young Adults In Texas, Anna V Wilkinson, Baojiang Chen, Alan C Swann, David P Graham, David A Nielsen, Thomas R Kosten, Alexandra Loukas, Dale S Mantey, Bara S Bataineh, Melissa B Harrell

Faculty, Staff and Students Publications

Introduction: Cigarette use and smoking intensity increase risk of suicidal ideation. Less is known about e-cigarette use. Here we examine direct influences of cigarette versus e-cigarette use on suicidal ideation among 16- to 23-year-olds in Texas.

Aims and methods: Since 2019, the Texas Adolescent Tobacco and Marketing Surveillance Study collected data on suicidal ideation every 6 months covering the previous 2 weeks. Youths answering that they had "thoughts that you would be better off dead, or of hurting yourself" on more than 2 of 14 days were categorized as having suicidal ideation. Generalized linear mixed-effects logistic regressions examined the influence …

Clocking In And Speaking Out: Navigating Workday Rhythms For Voice Behaviors, Katelyn M. Reeves

LSU Master's Theses

Employee voice behaviors help organizations identify problems, increase productivity, and enhance satisfaction. Most literature focuses on daily-level variations while neglecting potential within-day variations that may have a stronger impact on voice engagement. To investigate within-day variations, this thesis applies chronotype synchrony to explain resource depletion throughout the day, which will determine voice engagement. An experience sampling study with the day reconstruction method of 250 employees revealed that having a morning chronotype leads to a more promotive and prohibitive voice in the morning, with a decline throughout the day due to resource depletion increasing throughout the day. Further, individuals with evening …

Creating A Sustainable Platform For Indigenous Girls’ And Women’S Empowerment, Population Council

Adolescents and Young People

No abstract provided.

Ethical Aspects Of Utilising Artificial Intelligence In Clinical Settings, Jeffrey Byrnes, Michael Robinson

Philosophy Faculty Articles and Research

In response to recent proposals to utilize artificial intelligence (AI) to automate ethics consultations in healthcare, we raise two main problems for the prospect of having healthcare professionals rely on AI-driven programs to provide ethical guidance in clinical matters. The first cause for concern is that, because these programs would effectively function like black boxes, this approach seems to preclude the kind of transparency that would allow clinical staff to explain and justify treatment decisions to patients, fellow caregivers, and those tasked with providing oversight. The other main problem is that the kind of authority that would need to be …

"Fashion Forward": Fashioning Sociocultural Narratives Through Multimodal Critical Discourse Analysis Of Fashion Editorials, Nemuel N. Oliveros

Journal of English and Applied Linguistics

This qualitative study applies Multimodal Critical Discourse Analysis (MCDA) to decode sociocultural issues embedded in fashion editorials, addressing research questions about the sociocultural themes conveyed in the photos, the role of visual semiotics in the construction and presentation of each theme, and the sociocultural connotations contained therein. By employing thematic analysis and the modified version of Machin's Visual Semiotic Analysis framework tailored to the research context, the study systematically analyzes pose, gaze, social distance, objects, and settings in eight carefully selected fashion editorials, revealing nuanced sociocultural narratives. Under violence and exploitation, it reveals domestic violence and the commodification of women. …

Introduction: Failed Futures? (Post)-Colonial Planning And Future-Making In Tanzania, Ulrike Lindner

Zamani: A Journal of African Historical Studies

Future-making and planning as social practices are strongly related to the
surrounding society’s political structures and power relations. In this
special issue of ZAMANI, we conceptualize future-making as physical
changes and social practices that shape future conditions by making future
an issue in the present. We analyse how different approaches to the future,
and also surprises and unintended side-effects, have informed the politics
and practices of planning in Tanzania and its various regions.1 When we ask:
“Failed Futures?” we address future in the plural, a term that has diffused
into historical scholarship rather recently and originates from
futurology/future studies, known …

‘Sold Down The River’: Histories Of Production, Trade, And Transport Along The Waterways Of The Kilombero Valley, Tanzania, Jonathan M. Jackson

Zamani: A Journal of African Historical Studies

This article considers the centrality of waterways in the Kilombero Valley of Tanzania to the region’s histories of development from above, particularly in terms of infrastructure, crop production, trade, and transport. Early colonial investigations hoped Kilombero’s riverine system might prove a navigable link from the coast to the Southern Highlands. The British colonial era instead focused more on utilising riverine networks for internal goods transport. Throughout these colonial visions – simultaneously ambitious and naïve – the prevalent dug- out canoe was considered unsafe, inefficient, and replaceable by modernised methods. But the canoe – a symbol of indigenous knowledge and practice …

Imagining Hydropower: Transnational Narratives And Realities Of The Stiegler’S Gorge Project In Tanzania, 1960s–1980s, Emma Athanasio Minja

Zamani: A Journal of African Historical Studies

Hydropower development in the Global South has attracted several donor programmes for decades. How have such interventions shaped energy imaginations in Tanzania? Adopting a historical perspective and drawing on transnationalism and travelling frameworks, this article examines hydropower aid interventions and the dynamic shifts of specific actors and discourses in bilateral relations. The primary focus is on Norway, a leading actor in planning the Stiegler’s Gorge hydropower project in Tanzania’s Rufiji Basin in the 1970s to mid-1980s. It seeks to understand how, despite substantial aid support, the project failed to kick off in the face of the country’s post-independence drive for …

Nurturing Traditional Midwifery And Medicine: The Entangled Path Of Health Integration In Post-Independence Kilombero, Tanzania, Veronica Kimani

Zamani: A Journal of African Historical Studies

This paper focuses on the Tanzanian government’s ambitious endeavour to enhance health, particularly midwifery services following independence. The initial strategy by the government involved promoting Western medicine by establishing healthcare facilities and training medical personnel. However, the strain of a burgeoning population and limited resources soon became evident, prompting the government to recognise the need for the incorporation of traditional medicine, previously overlooked. This integration posed its own set of obstacles, as the focus on herbal remedies overshadowed crucial aspects of conventional midwifery, such as rituals. While research has shown the resolve of the government towards medical integration between different …

Health Infrastructure Planning In Tanzania, 1961–1980s: The Problems Of Future-Making, Frank Edward, Ulrike Lindner

Zamani: A Journal of African Historical Studies

Between 1961 and 1978, Tanzania invested significantly in the health service provision – from training requisite manpower, provision of health education to building the necessary infrastructure in order to improve health conditions of the population. As existing research indicates, the investment paid off considerably in qualitative terms, for instance, with a gradual increase in life expectancy and a decline in infant mortality. This paper examines the vision of the state of health in Tanzania by using the prism of infrastructure. Its focus is on direct and indirect physical infrastructures, particularly medical buildings and facilities. Through the analysis of archival and …

Transparency And Authority Concerns With Using Ai To Make Ethical Recommendations In Clinical Settings, Jeffrey Byrnes, Michael Robinson

Philosophy Faculty Articles and Research

In response to recent proposals to utilize artificial intelligence (AI) to automate ethics consultations in healthcare, we raise two main problems for the prospect of having healthcare professionals rely on AI-driven programs to provide ethical guidance in clinical matters. The first cause for concern is that, because these programs would effectively function like black boxes, this approach seems to preclude the kind of transparency that would allow clinical staff to explain and justify treatment decisions to patients, fellow caregivers, and those tasked with providing oversight. The other main problem is that the kind of authority that would need to be …

Front Matter - Zamani 1, No. 1, Editors Note

Zamani: A Journal of African Historical Studies

This is the maiden issue of Zamani: A Journal of African Historical Studies. It charts the beginning of a continental journal that is based in an African higher education institution within Africa. It breaks away from the traditional historical journals in Africa of being national or regional and at best being owned and operated by scholars and institutions from Europe and North America. With this maiden issue, the journal seeks to demonstrate that it is part of the bigger knowledge decolonization movement. It seeks to influence historical writing and research by giving more Africanness in ownership, operations, production and knowledge …

Medical Mission Futures: German Protestant Missionaries And Modern Healthcare In Southern Highlands, Tanzania,1891–1940, Luoneko Kaduma

Zamani: A Journal of African Historical Studies

The history of colonial missionaries in Tanzania is marked by a complex interplay between evangelical efforts and the provision of Western biomedicine, which functioned as crucial mechanisms for conversion and cultural transformation. Missionaries viewed the improvement of African health as a project aimed at attracting converts and propagating Christianity. However, the available data indicates that, instead of genuinely expressing interest in converting to Christianity, the majority of Africans primarily sought mission medical assistance for medical reasons while maintaining strong connections to their traditional beliefs and healing practices. This paper, drawing from archival documents, ethnographic accounts, and missionary writings, focuses on …

‘Prevention Is Better Than Cure’: Smallpox Vaccination In Postcolonial Tanzania, 1961–1980, Musa Sadock

Zamani: A Journal of African Historical Studies

This article examines the smallpox vaccination programme in postcolonial Tanzania from the 1960s to the early 1980s as part of the postcolonial future making in preventive medicine. The article departs from extant scholarship on smallpox vaccination in postcolonial Tanzania, which depicts the intervention as a success, while relegating to the background challenges associated with the intervention. The article argues that the smallpox vaccination programme registered challenges and successes that offer lessons for combating of future epidemics. The achievements of the programme were due to the adoption of specific public health policies, namely mass vaccination and public health education as well …

Some People Need Killing: Power Of Metaphors In Shaping And Challenging Political And Educational Realities, Rebecca Cyrene J. Lorenzana

Journal of English and Applied Linguistics

This study examines the significant role of metaphors in shaping and challenging political and educational discourse, focusing on the narratives from Patricia Evangelista's Some People Need Killing. Through Critical Metaphor Analysis (CMA), the research dissects how metaphors of war and criminality, dehumanization, salvation, and resistance function within the context of Rodrigo Duterte's War on Drugs in the Philippines. The study reveals that metaphors are not merely rhetorical devices but powerful tools that construct and perpetuate hegemonic structures, legitimizing state-sanctioned violence and dehumanizing individuals involved in drug-related activities. Conversely, metaphors of salvation and resistance offer alternative narratives that challenge these …

Preliminaries

Journal of English and Applied Linguistics

Abstract not applicable.

Compulsory Heterosexuality And Regulatory Hegemony In English Textbooks, Angelika Mae N. Balingasa

Journal of English and Applied Linguistics

Gender representations are crucial in textbooks given that these instructional materials are integral and widely-acknowledged in the field of education. However, despite various efforts to circumvent gender inequalities, textbooks still remain as conduits for proliferating gender biases and heteronormativity. In this study, secondary English textbooks were examined and sequential explanatory research design was used to investigate how genders were demonstrated in the textbooks through the lens of gender performativity theory. The findings revealed that the textbooks adhered to historical gender conventions, as opposed to genders’ fluid and contingent nature. Additionally, all of the textbooks promote hegemonic masculinity with men dominating …