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Articles 124831 - 124860 of 1793209
Full-Text Articles in Entire DC Network
Investigating The Internal And External Load Associated With Umpiring Semi-Professional Australian Rules Football, Corey Wilson, Mark Scanlan, Colin S. Doherty, Oliver R. Barley
Investigating The Internal And External Load Associated With Umpiring Semi-Professional Australian Rules Football, Corey Wilson, Mark Scanlan, Colin S. Doherty, Oliver R. Barley
Research outputs 2022 to 2026
Background: This investigation examined internal and external load associated with umpiring semi-professional Australian Rules football, an area of limited research. Objective: This exploratory quantitative study recruited 39 field umpires (Age: 25.2 ± 6.8 y, Body Mass: 74.6 ± 7.9 kg, Height: 178.9 ± 7.4 cm) from the Western Australian Football League (WAFL). Each participant was assessed in one match only. Methodology: External measures (total distance [TD], floating distance [FSD], high-intensity running distance [HSD]) and internal measures (blood lactate [BLa], heart rate [HR], rating of perceived exertion [RPE]) were collected during 22 matches, of the 2023 WAFL season. Data collection was …
Pleural Infection: Controversies On The Therapeutic Strategies, Ken K.P. Chan, Estee P.M. Lau, Y. C. Gary Lee
Pleural Infection: Controversies On The Therapeutic Strategies, Ken K.P. Chan, Estee P.M. Lau, Y. C. Gary Lee
Research outputs 2022 to 2026
Purpose of review Management of pleural infection remains heterogeneous worldwide. This review highlights current controversies in therapeutic strategies for pleural infection, focusing particularly on recent studies and their implications. Recent findings The introduction of intrapleural therapy combining alteplase [a tissue plasminogen activator (tPA)] and deoxyribonuclease (DNase) has revolutionized treatment practices, though the optimal delivery and dosing regimen is an area of active investigation. Variations to simplify administration protocols and/or to lower the required drug doses have been published. Most were exploratory studies, but the variations showed maintained therapeutic efficacy. Whether intrapleural alteplase/DNase or video-assisted thoracoscopic surgery (VATS) is superior is …
Early Changes In Spatiotemporal Dynamics Of Remapped Circuits And Global Networks Predict Functional Recovery After Stroke In Mice, Ryan M Bowen, Jake Lee, Brendon Wang, Keith R Lohse, Hanyang Miao, Jonah A Padawer-Curry, Asher J Albertson, Eric C Landsness, Adam Q Bauer, Jin-Moo Lee
Early Changes In Spatiotemporal Dynamics Of Remapped Circuits And Global Networks Predict Functional Recovery After Stroke In Mice, Ryan M Bowen, Jake Lee, Brendon Wang, Keith R Lohse, Hanyang Miao, Jonah A Padawer-Curry, Asher J Albertson, Eric C Landsness, Adam Q Bauer, Jin-Moo Lee
2020-Current year OA Pubs
SIGNIFICANCE: Stroke is the leading cause of chronic disability in the United States. How stroke size affects post-stroke repair and recovery is poorly understood.
AIM: We aim to investigate the effects of stroke size on early repair patterns and determine how early changes in neuronal circuits and networks predict functional outcomes after stroke.
APPROACH: We used wide-field optical imaging, photothrombosis, and the cylinder-rearing assay to examine changes in neuronal circuit and network activity in the context of functional recovery after stroke.
RESULTS: Larger strokes ablating
CONCLUSIONS: These results suggest that diffuse patterns of remapping, and desynchronization and hyperconnectivity of cortical …
Nutcracker Syndrome (A Delphi Consensus), Floor Heilijgers, Suresh Vedantham, Et Al.
Nutcracker Syndrome (A Delphi Consensus), Floor Heilijgers, Suresh Vedantham, Et Al.
2020-Current year OA Pubs
BACKGROUND: Nutcracker syndrome (NCS) describes the symptomatic compression of the left renal vein between the aorta and superior mesenteric artery. Whereas asymptomatic compression is a common radiological finding, patients with NCS can report a range of symptoms. There are no specific diagnostic criteria and interventions include a range of open surgical and endovascular procedures. Therefore, we wished to develop an international consensus document covering aspects of diagnosis, management, and follow-up for patients with NCS.
METHODS: A three-stage modified Delphi consensus was performed. A steering committee developed 37 statements covering 3 categories for patients with NCS: diagnosis, management, and follow-up. These …
Head-To-Head Preclinical Treatment Design Prioritizes Promising Therapies For Neurofibromatosis Type 1 Optic Glioma Clinical Translation, Talia Eligator, Jit Chatterjee, Shintaro Yamada, Anthony Kirchner, Hareesh B Nair, Jason R Fangusaro, David H Gutmann
Head-To-Head Preclinical Treatment Design Prioritizes Promising Therapies For Neurofibromatosis Type 1 Optic Glioma Clinical Translation, Talia Eligator, Jit Chatterjee, Shintaro Yamada, Anthony Kirchner, Hareesh B Nair, Jason R Fangusaro, David H Gutmann
2020-Current year OA Pubs
BACKGROUND: Authenticated preclinical brain tumor models provide unprecedented opportunities to evaluate next-generation treatments. However, some therapies with robust anti-tumor activity in mice fail in human trials, highlighting the need to better prioritize candidates for clinical translation. Herein, we implemented a head-to-head preclinical strategy using a well-characterized murine model of NF1-optic pathway glioma (
METHODS:
RESULTS: While all agents restored normal tissue architecture, reduced ON proliferation, and decreased TME soluble mediator and tumor cell marker RNA expression, only lamotrigine and mirdametinib also reduced ON volume. Everolimus, lamotrigine, and HBS-101 restored RNFL thickness to wild-type levels, whereas carboplatin showed a trend towards …
Carpal Tunnel Syndrome And Occupational Co-Exposure To Biomechanical Factors And Neurotoxic Chemicals Using Job-Exposure Matrices And Self-Reported Exposure: Findings From The Constances Cohort, Julie Bodin, Clémence Rapicault, Alexis Descatha, Marc Fadel, Fabien Gilbert, Bradley Evanoff, Nathalie Bonvallot, Marcel Goldberg, Marie Zins, Yves Roquelaure
Carpal Tunnel Syndrome And Occupational Co-Exposure To Biomechanical Factors And Neurotoxic Chemicals Using Job-Exposure Matrices And Self-Reported Exposure: Findings From The Constances Cohort, Julie Bodin, Clémence Rapicault, Alexis Descatha, Marc Fadel, Fabien Gilbert, Bradley Evanoff, Nathalie Bonvallot, Marcel Goldberg, Marie Zins, Yves Roquelaure
2020-Current year OA Pubs
OBJECTIVE: To study the association between occupational co-exposure to biomechanical risk factors, potentially neurotoxic chemicals and carpal tunnel syndrome (CTS) in a large cohort of French workers, using two methods to estimate chemical exposure: job-exposure matrices (JEM) and self-reported exposure.
METHODS: A randomly selected sample of adults were included between 2012 and 2018 in the French cohort CONSTANCES. Self-reported CTS was assessed using the first self-administered follow-up questionnaire, sent out approximately one year after baseline. Occupational exposure to biomechanical risk factors was assessed using self-administered questionnaire completed at inclusion. Lifetime occupational exposure to chemicals was assessed using two different methods: …
Ecological Grief: How Can We Bear This Together?, Susan Bailey, Nicholas Gerrish
Ecological Grief: How Can We Bear This Together?, Susan Bailey, Nicholas Gerrish
Research outputs 2022 to 2026
The impacts of human activity on ecosystems are increasingly evident through ecological degradation and climate change. Despite this, in many jurisdictions across the world, action to address and curtail destructive human activities is slow and resisted at all levels. In this article, we suggest that this resistance is connected to deep ecological grief. We introduce a dual approach to understanding ecological grief, using concepts of unprecedented and unacknowledged grief. Unprecedented grief is felt in response to the loss of our ecosystems and unacknowledged grief connected to the anticipated loss of lifestyle necessary to curtail destructive human behaviour. Drawing upon an …
Intervention Accuracy And Perception Of Fatigue In State-Level Australian Football Umpires, Corey Wilson, Mark Scanlan, Duncan G. Bradbury, Oliver R. Barley
Intervention Accuracy And Perception Of Fatigue In State-Level Australian Football Umpires, Corey Wilson, Mark Scanlan, Duncan G. Bradbury, Oliver R. Barley
Research outputs 2022 to 2026
This investigation examined intervention accuracy and perception of fatigue associated with umpiring state-level Australian Rules football (AF). 39 field umpires (Age: 25.2 ± 6.8 y, Body Mass: 74.6 ± 7.9 kg, Height: 178.9 ± 7.4 cm) employed by the Western Australian Football Commission, were recruited. Intervention accuracy (whether given free kicks were correct) was analysed post-event by the lead investigator using footage of the matches, with two umpire coaches being used for reliability. Perception of fatigue was assessed pre- and post-match using a questionnaire. Data was collected in 22 Western Australian Football League matches in the 2023 season. 384 free …
Business Model Innovation Through Ai Adaptation: The Role Of Strategic Human Resources Management, Sanjit K. Roy, Bidi L. Dey, David M. Brown, Aman Abid, Chrysostomos Apostolidis, Michael Christofi, Shlomo Tarba
Business Model Innovation Through Ai Adaptation: The Role Of Strategic Human Resources Management, Sanjit K. Roy, Bidi L. Dey, David M. Brown, Aman Abid, Chrysostomos Apostolidis, Michael Christofi, Shlomo Tarba
Research outputs 2022 to 2026
While artificial intelligence (AI) requires business model innovation, it simultaneously poses persistent operational, regulatory and strategic challenges, highlighting the importance of researching AI adaptation to appropriate organizational value. AI adaptation is not monolithic, and its nature and consequent value appropriation processes may vary due to external factors and an organization's strategic approach to innovation and resource management. Accordingly, a taxonomy of AI adaptation and its link with value appropriation can yield a theoretical understanding and practical implications of why and how organizations vary in leveraging strategic human resource management to shape business innovation led by AI adaptation. In this paper, …
Patient Perception Of Involvement In Nursing Bedside Handover: A Cross-Sectional Study, Manonita Ghosh, Kaoru Nosaka, Rosemary Saunders, Olivia Gallagher, Amanda Towell-Barnard, Debannita Ghosh, Lucy Gent, Linda Coventry
Patient Perception Of Involvement In Nursing Bedside Handover: A Cross-Sectional Study, Manonita Ghosh, Kaoru Nosaka, Rosemary Saunders, Olivia Gallagher, Amanda Towell-Barnard, Debannita Ghosh, Lucy Gent, Linda Coventry
Research outputs 2022 to 2026
Background: In Australia, aligned to safety and quality standards, the health system implements standardised practices that include patient involvement in nursing bedside handover. Despite this mandate, it remains unclear whether patients are genuinely participating in nursing bedside handovers and whether their perspectives are being considered. Aim: To explore patient perceptions of their involvement in nursing bedside handovers. Methods: A cross-sectional survey study was conducted in two acute metropolitan hospitals in Western Australia from July 2021 to March 2022. The survey administered to patients, comprised three sections: demographic information; involvement in bedside handover; and perceptions of bedside handovers; utilising close-ended and …
Planned Changes To Nurse Leadership, Staffing And Skill-Mix: Impact On The Working Environment, Job Satisfaction And Intention To Leave, Noeleen Brady, Selena O'Connell, David Gilligan, Caoimhe Madden, Lisa Gannon, Victoria Howson, Jane E. Ball, Aileen Murphy, Peter Griffiths, Christine Duffield, P. Anne Scott, Vera J.C. Mc Carthy, Jonathan Drennan
Planned Changes To Nurse Leadership, Staffing And Skill-Mix: Impact On The Working Environment, Job Satisfaction And Intention To Leave, Noeleen Brady, Selena O'Connell, David Gilligan, Caoimhe Madden, Lisa Gannon, Victoria Howson, Jane E. Ball, Aileen Murphy, Peter Griffiths, Christine Duffield, P. Anne Scott, Vera J.C. Mc Carthy, Jonathan Drennan
Research outputs 2022 to 2026
Introduction: Job satisfaction and intention to leave have been consistently linked to the working environment. However, there are few studies of interventions for improving the environment or staff outcomes. Aim: To determine the impact of implementing a framework for safe nurse staffing on the environment and staff outcomes. This involved an assessment of required nursing hours per patient day, supernumerary nurse in charge and minimum 80:20 skill-mix, with intentional changes in staffing if required. Design: A pre-post observational design. Methods: This was a prospective observational study in six medical and/or surgical wards across three acute hospitals in Ireland. The outcomes …
Return To On-Snow Performance In Ski Racing After Anterior Cruciate Ligament Reconstruction, Nathaniel Morris, Ricardo Da Silva Torres, Mark Heard, Patricia Doyle Baker, Walter Herzog, Matthew J. Jordan
Return To On-Snow Performance In Ski Racing After Anterior Cruciate Ligament Reconstruction, Nathaniel Morris, Ricardo Da Silva Torres, Mark Heard, Patricia Doyle Baker, Walter Herzog, Matthew J. Jordan
Research outputs 2022 to 2026
Background: The individual variation in on-snow performance outcomes after anterior cruciate ligament (ACL) reconstruction (ACLR) in elite alpine ski racers has not been reported and may be influenced by specific injury characteristics. Purpose: To report the performance statistics of elite ski racers before and after ACLR and to identify surgical and athlete-specific factors that may be associated with performance recovery. Study Design: Descriptive epidemiological study. Methods: International Ski and Snowboard Federation (FIS) points, FIS ranking, average placing, and average percentage behind the winning time in each race were calculated for 30 national and provincial team ski racers at 1 year …
Weight Stigma Amongst Nurses And Nursing Students: A Scoping Review Of Direct And Comparative Evidence, Mahshid Fonoudi, Beverley Ewens, Amanda Towell-Barnard
Weight Stigma Amongst Nurses And Nursing Students: A Scoping Review Of Direct And Comparative Evidence, Mahshid Fonoudi, Beverley Ewens, Amanda Towell-Barnard
Research outputs 2022 to 2026
Aim: To map both direct and comparative research on weight stigma amongst nurses and nursing students by identifying the extent, range and nature of studies and identify the gaps in this area. Design: Scoping review, following the Joanna Briggs Institute (JBI) guidelines. Data Sources: Seven databases including MEDLINE, Web of Science, CINAHL, Embase, Scopus, PsycINFO and Cochrane Library, in addition to Google Scholar and Open Access Theses and Dissertations were systematically searched in August 2023. Methods: Inclusion criteria comprised nurses or nursing students as participants, weight stigma as the concept and any context. After uploading all search results into EndNote …
Evaluating Impact Of Educational Research On Teachers’ Practice: A Teacher Expectations Intervention, Olivia Johnston
Evaluating Impact Of Educational Research On Teachers’ Practice: A Teacher Expectations Intervention, Olivia Johnston
Research outputs 2022 to 2026
Educational research that generates new knowledge can have a positive impact on teaching practice, yet few methods have been developed to show if, and how, knowledge-based research translation has any impact on teachers’ professional practices. The research reported in this paper evaluated the impact of a Teacher Expectations Intervention on teachers’ practice. The intervention disseminated new knowledge about teaching practices that communicate high expectations to students. Graham et al.’s (2006) Knowledge-to-Action Framework provided a conceptual framework to develop, implement and evaluate the intervention with the participant teachers. The findings show that 61 secondary-school teachers experienced overall positive impact on their …
Integration Of Virtual Simulation Within A Nursing Curriculum: A Mixed Methods Study, Martina Costello, Hugh Davies, Fiona Williams, Michelle Gay, Jennifer Jennings, Joyce Muge-Sugutt, Olivia Gallagher
Integration Of Virtual Simulation Within A Nursing Curriculum: A Mixed Methods Study, Martina Costello, Hugh Davies, Fiona Williams, Michelle Gay, Jennifer Jennings, Joyce Muge-Sugutt, Olivia Gallagher
Research outputs 2022 to 2026
Background: Virtual simulation is a valuable learning tool for health professionals to facilitate knowledge, skills, and confidence. Simulation-based learning in Nursing has increased with advances in digital technologies, embedding diverse virtual modalities. The integration of virtual simulations requires careful consideration of pedagogical approaches and implementation strategies. The vSim® for Nursing platform was integrated into the curriculum of an undergraduate nursing program at an Australian university to enhance clinical learning experiences. Aim: To evaluate the implementation of the vSim® for Nursing learning platform within the second-year curriculum. Methods: A mixed-methods cross-sectional survey design was used, guided by Kirkpatrick's training evaluation model. …
Open Educational Resources In Epidemiology: A Case Study Of Student Perceptions, Kiam Padamsey
Open Educational Resources In Epidemiology: A Case Study Of Student Perceptions, Kiam Padamsey
Research outputs 2022 to 2026
Textbooks are fundamental in epidemiological education, but their rising costs and static nature present challenges in an ever-evolving academic landscape. Open Educational Resources (OER) offer a potential solution by providing free, adaptable, and high-quality alternative learning materials. This study examined student perceptions of an OER textbook compared to a traditional epidemiology textbook across undergraduate and postgraduate epidemiology units at Edith Cowan University, Western Australia. A total of n = 164 students responded to a survey assessing textbook quality, alignment with course objectives, clarity, and perceived impact on learning. Results indicated students perceived no significant differences between the traditional and OER …
Truth Telling And The “Lead Splinter”: Aboriginal Elders’ Perspectives On Community Service Provision And Intergenerational Trauma, Janelle Caddy, Eyal Gringart, Darren Garvey
Truth Telling And The “Lead Splinter”: Aboriginal Elders’ Perspectives On Community Service Provision And Intergenerational Trauma, Janelle Caddy, Eyal Gringart, Darren Garvey
Research outputs 2022 to 2026
This article is based on PhD research aimed at improving community services for remote Aboriginal people with intergenerational trauma. It focuses on the role that Yamatji Aboriginal Elders played in cocreating a framework to enhance service provision for Aboriginal clients and the importance of local truth telling in this endeavour. Elders specified that local truth telling was essential in building shared understandings of healing from intergenerational trauma between Aboriginal people and community service providers. The characterisation of intergenerational trauma as a “lead splinter”, continually poisoning the wellbeing of Aboriginal people provided an illustration of trauma and the complexities of facilitating …
White Supremacy On The Whiteboard: Teachers’ Responses To The Christchurch Mosque Attacks, Genaro Oliveira, Abdelhamid Safa
White Supremacy On The Whiteboard: Teachers’ Responses To The Christchurch Mosque Attacks, Genaro Oliveira, Abdelhamid Safa
Research outputs 2022 to 2026
This article explores how pre-service and secondary teachers in New Zealand have responded to the themes of white supremacy and terrorism in the aftermath of the Christchurch Mosque attacks on 15 March 2019. The research questions focus on teachers’ views on the role of schools and teachers in addressing white supremacy and violent extremism. The study utilises a mixed-methods approach drawing on a survey of social sciences secondary teachers nationwide and first-hand accounts from pre-service teachers during the attacks. While the immediate responses of New Zealand politicians, police officers, firefighters, and the Muslim community garnered significant attention, this research aims …
Telemedicine For Under-Resourced Patients With Systemic Lupus Erythematosus: A Qualitative Study Exploring The Views And Experiences Of Patients And Their Healthcare Team, Savannah Bowman, Sandeep K Agarwal, Keshia C Ferguson, Maryjo J Maliekel, Maria A Lopez-Olivo, Maria E Suarez-Almazor, Maria I Danila, Jinoos Yazdany, Sebastian Bruera
Telemedicine For Under-Resourced Patients With Systemic Lupus Erythematosus: A Qualitative Study Exploring The Views And Experiences Of Patients And Their Healthcare Team, Savannah Bowman, Sandeep K Agarwal, Keshia C Ferguson, Maryjo J Maliekel, Maria A Lopez-Olivo, Maria E Suarez-Almazor, Maria I Danila, Jinoos Yazdany, Sebastian Bruera
Faculty, Staff and Students Publications
Objectives: There is scarce knowledge on the benefits, limitations, and acceptance of telemedicine in patients with systemic lupus erythematosus (SLE), particularly in those from under-resourced groups. We aimed to assess the experiences and views on telemedicine of people with SLE, clinicians, and nursing staff from a safety net healthcare system in Harris County, Texas, defined as a hospital network that primarily serves low-income, uninsured, and vulnerable populations.
Methods: We conducted semi-structured 1:1 in-person interviews of patients with SLE and their clinical team members, in Harris County, Texas. Using Levesque's conceptual framework for healthcare access, semi-structured interviews and content analysis were …
The Uses Of Right Heart Catheterization In Cardio-Pulmonary Disease: State-Of-The-Art, Bhavesh Katbamna, Lingling Wu, Mario Rodriguez, Phillip King, Joel Schilling, Jamal Mahar, Ajith P Nair, Hani Jneid, Elizabeth S Klings, Gerald L Weinhouse, Sula Mazimba, Marc A Simon, Markus Strauss, Chayakrit Krittanawong
The Uses Of Right Heart Catheterization In Cardio-Pulmonary Disease: State-Of-The-Art, Bhavesh Katbamna, Lingling Wu, Mario Rodriguez, Phillip King, Joel Schilling, Jamal Mahar, Ajith P Nair, Hani Jneid, Elizabeth S Klings, Gerald L Weinhouse, Sula Mazimba, Marc A Simon, Markus Strauss, Chayakrit Krittanawong
Faculty, Staff and Students Publications
The right heart catheterization (RHC) remains an important diagnostic tool for a spectrum of cardiovascular disease processes including pulmonary hypertension (PH), shock, valvular heart disease, and unexplained dyspnea. While it gained widespread utilization after its introduction, the role of the RHC has evolved to provide valuable information for the management of advanced therapies in heart failure (HF) and cardiogenic shock (CS) to name a few. In this review, we provide a comprehensive overview on the indications, utilization, complications, interpretation, and calculations associated with RHC.
The Department Of Cardiovascular Anesthesia Of The Texas Heart Institute: An Informal History, John R Cooper, N Martin Giesecke
The Department Of Cardiovascular Anesthesia Of The Texas Heart Institute: An Informal History, John R Cooper, N Martin Giesecke
Faculty, Staff and Students Publications
No abstract provided.
Research Methodology Education In Europe: A Multi-Country, Cross-Disciplinary Survey Of Current Practices And Perspectives, Silke Kniffert, Ivan Buljan, Flavio Azevedo, Peter Babinčák, Lucija Batinović, Thomas Rhys Evans, Sara Garofalo, Christopher Graham, Lucianne Groenink, Malika Ihle, Milosav Klugar, Lucia Kočišová, Michal Kohút, Nikolaos Kostomitsopoulos, Seán Lacey, Anita Lunić, Ana Marušić, Thomas Nordström, Charlotte R. Pennington, Daniel Pizzolato, Ulf Toelch, Marta Topor, Miro Vuković, Michiel R. De Boer
Research Methodology Education In Europe: A Multi-Country, Cross-Disciplinary Survey Of Current Practices And Perspectives, Silke Kniffert, Ivan Buljan, Flavio Azevedo, Peter Babinčák, Lucija Batinović, Thomas Rhys Evans, Sara Garofalo, Christopher Graham, Lucianne Groenink, Malika Ihle, Milosav Klugar, Lucia Kočišová, Michal Kohút, Nikolaos Kostomitsopoulos, Seán Lacey, Anita Lunić, Ana Marušić, Thomas Nordström, Charlotte R. Pennington, Daniel Pizzolato, Ulf Toelch, Marta Topor, Miro Vuković, Michiel R. De Boer
Publications
Background
Research methodology education aims to equip students with the foundational knowledge of robust scientific practices, emphasizing deep understanding of scientific inquiry, integrity, and critical thinking in research practice. A literature review reveals that the observed diversity in research methods course design and instruction stems from a lack of consensus about the essential foundations required to critically engage with, design, and execute research in education. This is further compounded by a limited pedagogical innovation. However, no study has yet investigated how research methodology is taught and perceived across European universities. The objective of this study is to examine practices and …
Variants In Washc3, A Component Of The Wash Complex, Cause Short Stature, Variable Neurodevelopmental Abnormalities, And Distinctive Facial Dysmorphism, Youn Hee Jee, Julian C Lui, Dana Marafi, Zhi-Jie Xia, Ruchika Bhatia, Elaine Zhou, Isabella Herman, Adrian Temnycky, Philip Whalen, Gene Elliot, Ellen W Leschek, Robin Wijngaard, Ronald Van Beek, Annemarie De Vreugd, Maaike C De Vries, Clara D M Van Karnebeek, Machteld M Oud, Thomas C Markello, Kevin M Barnes, Hadil Alrohaif, Hudson H Freeze, William A Gahl, May Christine V Malicdan, Jennifer E Posey, James R Lupski, Jeffrey Baron
Variants In Washc3, A Component Of The Wash Complex, Cause Short Stature, Variable Neurodevelopmental Abnormalities, And Distinctive Facial Dysmorphism, Youn Hee Jee, Julian C Lui, Dana Marafi, Zhi-Jie Xia, Ruchika Bhatia, Elaine Zhou, Isabella Herman, Adrian Temnycky, Philip Whalen, Gene Elliot, Ellen W Leschek, Robin Wijngaard, Ronald Van Beek, Annemarie De Vreugd, Maaike C De Vries, Clara D M Van Karnebeek, Machteld M Oud, Thomas C Markello, Kevin M Barnes, Hadil Alrohaif, Hudson H Freeze, William A Gahl, May Christine V Malicdan, Jennifer E Posey, James R Lupski, Jeffrey Baron
Faculty, Staff and Students Publications
Purpose: Genetic defects that impair growth plate chondrogenesis cause a phenotype that varies from skeletal dysplasia to mild short stature with or without other syndromic features. In many individuals with impaired skeletal growth, the genetic causes remain unknown.
Method: Exome sequence was performed in 3 unrelated families with short stature, distinctive facies, and neurodevelopmental abnormalities. The impact of identified variants was studied in vitro.
Results: Exome sequencing identified variants in WASHC3, a component of the WASH complex. In the first family, a de-novo-dominant missense variant (p.L69F) impaired WASHC3 participation in the WASH complex, altered PTH1R endosomal trafficking, diminished PTH1R …
Id-Gba: Subgraph Extension With Information Distance Guilt By Association In Complex Networks, Predrag Obradovic, Vladimir Kovacevic, Aleksandar Milosavljevic, Varduhi Petrosyan
Id-Gba: Subgraph Extension With Information Distance Guilt By Association In Complex Networks, Predrag Obradovic, Vladimir Kovacevic, Aleksandar Milosavljevic, Varduhi Petrosyan
Faculty, Staff and Students Publications
Here, we introduce the ID-GBA (Information Distance Guilt By Association) method to expand highly connected sets of nodes by deploying a novel algorithm for subgraph extension based on the guilt-by-association principle and information distance. In this study, ID-GBA was utilized to expand disease clusters, and identify novel disease genes. We first validate its ability to expand related disease sets from disease/disease graphs built using Open Targets' gene association scores. We then analyze disease/control gene expression networks and show that ID-GBA recaptures known disease genes in nine disease/control graphs. Compared to existing methods such as Random Walk with Restarts and Personalized …
Correction: Health-Related Quality Of Life After Neonatal Treatment Of Symptomatic Tetralogy Of Fallot: Insights From The Congenital Cardiac Research Collaborative, George T Nicholson, Jeffrey D Zampi, Andrew C Glatz, Bryan H Goldstein, Christopher J Petit, Yun Zhang, Courtney E Mccracken, Athar M Qureshi, Caren S Goldberg, Jennifer C Romano, Mark A Law, Jeffery J Meadows, Shabana Shahanavaz, Sarosh P Batlivala, Shiraz A Maskatia, Asaad Beshish, Michael L O'Byrne, R Allen Ligon, Kathryn O Stack, Hala Q Khan, Shalin Parekh, Dawn L Ilardi
Correction: Health-Related Quality Of Life After Neonatal Treatment Of Symptomatic Tetralogy Of Fallot: Insights From The Congenital Cardiac Research Collaborative, George T Nicholson, Jeffrey D Zampi, Andrew C Glatz, Bryan H Goldstein, Christopher J Petit, Yun Zhang, Courtney E Mccracken, Athar M Qureshi, Caren S Goldberg, Jennifer C Romano, Mark A Law, Jeffery J Meadows, Shabana Shahanavaz, Sarosh P Batlivala, Shiraz A Maskatia, Asaad Beshish, Michael L O'Byrne, R Allen Ligon, Kathryn O Stack, Hala Q Khan, Shalin Parekh, Dawn L Ilardi
Faculty, Staff and Students Publications
No abstract provided.
Affective Forecasting With A Chance Of Collective Action: Women’S Anticipated Affect After Acting Against Sexism And Its Relationship To Collective Action Intentions, Adrianna Tassone
Theses and Dissertations (Comprehensive)
Confronting sexism elicits social costs like name-calling (Mendes et al., 2018) and anticipating these costs inhibits confrontation (Good et al., 2012). But taking collective action can also improve women’s wellbeing and reduce negative emotion (Foster, 2015). How women anticipate their own emotions in response to social cost may be a predictor of action. However, it is not yet known how women anticipate taking action will make them feel, and how perceived costs relate to these predictions and action intentions. The present thesis integrates two previously distinct literatures, affective forecasting (Gilbert et al., 1998) and collective action motivation to assess the …
Coupling Remote Sensing And Modelling To Monitor The Spatial Distribution And Trends Of Surface Temperature And Ice Thickness On Sub-Arctic Lakes, Gifty Attiah
Theses and Dissertations (Comprehensive)
Lake surface temperature (LST), lake ice thickness (LIT), and lake ice phenology (LIP) play significant roles in the diverse regional processes of freshwater in cold regions. They offer direct indications of regional weather and climate conditions, and their interactions with the atmosphere impact climate processes. Furthermore, lake ice is valuable to northern communities, such as those in the Northwest Territories (NWT). Ice roads, including the longest ice road in the NWT, spanning over 80 lakes, are constructed during winter to haul goods to and from industrial establishments (e.g., mines) and for travel within and between communities. A significant challenge to …
The Impacts Of Permafrost Thaw Slumps On Arctic Stream Ecology, Maria Dolan
The Impacts Of Permafrost Thaw Slumps On Arctic Stream Ecology, Maria Dolan
Theses and Dissertations (Comprehensive)
Climate change is intensifying permafrost thaw across terrain of the circumpolar Arctic. Increased temperatures and rainfall at northern latitudes have resulted in the expansion of thermokarst features such as retrogressive thaw slumps, which make previously frozen debris available for transport into nearby river systems. In the Peel Plateau, Northwest Territories, the mobilization of these materials exposes rivers to a large quantity of sediment and solutes that may act as a chronic, press disturbance, potentially altering stream food webs. Here, I examine if: 1) thaw slumps have driven changes to the physical and biological properties of slump impacted streams since an …
Children's Interpretation Of Others' Faces Covered With Medical Masks, Sevval Cinar
Children's Interpretation Of Others' Faces Covered With Medical Masks, Sevval Cinar
Theses and Dissertations (Comprehensive)
How we recognize and regulate emotions is fundamental to overall health and wellbeing. Emotional recognition and understanding are key to proper communication and emotion regulation. Barriers, such as masks, might have an impact on the way children recognize and interpret others' emotions, and therefore the way they learn, communicate, and regulate their own. The COVID-19 pandemic necessitated widespread mask-wearing, raising questions about its impact on children’s emotional development. Using a sample of children with varying levels of exposure to mask wearing adults (N= 13, ages 4 to 6), we investigated how prolonged mask wearing predicts emotion recognition, particularly …
Capital Structure Models And Contingent Convertible Securities, Di Meng
Capital Structure Models And Contingent Convertible Securities, Di Meng
Theses and Dissertations (Comprehensive)
The 2007-09 financial crisis showed financial institutions are vulnerable during distressed times. As an alternative resolution to a government bail-out, contingent convertible securities (contingent capital or CoCos) were proposed by various researchers. CoCo is a hybrid capital security that converts from a bond to common equity when a pre-determined event occurs. The loss absorption mechanism of CoCo is essential to the financial health of a bank during a crisis as it provides an instant capital infusion when public capital is difficult to access.
In this thesis, we first implement a methodology to calibrate capital structure models for large Canadian banks. …