Digital Commons Network^™

Psychological Implications Of Preterm Birth, Livio Provenzi, Minesh Khashu, Mia Mclean, Evalotte Morelius

Research outputs 2022 to 2026

No abstract provided.

Exploring The Barriers To Mental Health Help-Seeking Among African Migrants In Australia: A Qualitative Study, Nnaemeka Meribe, Obed Adonteng-Kissi, Kathomi Gatwiri, Lillian Mwanri, Frank Darkwa Baffour, Agness Tembo, Edith N. Botchway-Commey, David Chisanga, Ahmed A. Moustafa, Kerrie E. Doyle, Uchechukwu Levi Osuagwu

Research outputs 2022 to 2026

Background: The health of African migrants in Australia is a largely under-researched topic despite the steadily increasing size of the population and its uniqueness. In particular, few studies have explored the mental health of African migrants in Australia or their utilization of mental health services.

Aims: This study explored the barriers to mental health help-seeking among first-generation African migrants in Australia.

Methods: In this qualitative study conducted using the hermeneutical phenomenological research approach, the purposive sampling method was used to recruit participants. In-depth interviews with participants were undertaken online via Zoom, Teams, and WhatsApp calls. Interviews were recorded and transcribed …

Fostering A Resilient Healthcare System: Supportive Practice Environment Initiatives To Support Nurse And Midwives A Scoping Review, Gemma Doleman, Dianne Bloxsome, Rong Wang, Lisa Whitehead

Research outputs 2022 to 2026

Aim: This scoping review aimed to explore supportive practice environment initiatives that support novice and expert nurses and midwives. Design: Scoping review. Methods: Studies were identified through the electronic databases Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDLINE, PsychInfo, Scopus, and Web of Science. Grey literature was searched using GreyNet, National Grey Literature Collection, ProQuest Dissertation and Theses, and Google Scholar. Results: Thirty-one papers met the criteria for inclusion and data extraction. The key concepts identified were the need for adequate staffing and resources, clear and regular communication, managerial presence and engagement in committees and relationship building, celebration …

Gestational Age–Specific Prevalence Of Preeclampsia Among Pregnant Women In Ghana: A Hospital-Based Retrospective Observational Study, Wina Ivy Ofori Boadu, Enoch Odame Anto, Akua Benewaah Asamoah, Ezekiel Ansah, Godfred Yawson Scott, Emmanuel Ekow Korsah, Joseph Frimpong, Valentine Christian Kodzo Tsatsu Tamakloe, Michael Nyantakyi, Agartha Odame Anto, Emmanuel Timmy Donkoh, Kwame Ofori Boadu, Richard Vikpebah Duneeh, Frederick Ayensu, Christian Obirikorang

Research outputs 2022 to 2026

Background: Preeclampsia is responsible for a significant rate of maternal morbidity and mortality worldwide. Gestational age as a risk factor has a significant impact on fetal outcomes in pregnancies affected by preeclampsia. However, to our knowledge, no study has identified the gestational age–specific prevalence of preeclampsia in Ghana. Thus, this study ascertained the gestational age–specific prevalence of preeclampsia as well as its associated factors. Methods: A hospital-based retrospective observational study was conducted by reviewing data collected from the maternal birth register on 619 pregnant women who delivered at the facility from 1st January 2021 to 31st December 2021. Results: Out …

Prevalence And Profile Of New Zealand Osteopaths Treating People Experiencing Headaches And Migraines, Ana Paula Antunes Ferreira, Brett Vaughan, Jerry Draper-Rodi, Lee Muddle, Loïc Treffel, Cindy Mcintyre, Michael Fleischmann, Francesco Cerritelli, Kesava Kovanur Sampath, Amie Steel

Research outputs 2022 to 2026

To describe the prevalence and profile of NZ osteopaths treating people experiencing headaches and migraines. This study is the first to describe this practice. Manual and manipulative therapy interventions are commonly sought by individuals experiencing headaches or migraines. Evidence supports the use of manual therapy as part of the management of headache and migraine disorders. Osteopaths are health professionals who provide care for individuals experiencing headaches and migraines. However, there is a lack of data concerning the profile of osteopaths treating these conditions, in addition to their diagnostic and management strategies. The Osteopathy Research Connect-New Zealand (ORC-NZ), a practice-based research …

Review Of Applications Of Deep Learning In Veterinary Diagnostics And Animal Health, Sam Xiao, Navneet K. Dhand, Zhiyong Wang, Kun Hu, Peter C. Thomson, John K. House, Mehar S. Khatkar

Research outputs 2022 to 2026

Deep learning (DL), a subfield of artificial intelligence (AI), involves the development of algorithms and models that simulate the problem-solving capabilities of the human mind. Sophisticated AI technology has garnered significant attention in recent years in the domain of veterinary medicine. This review provides a comprehensive overview of the research dedicated to leveraging DL for diagnostic purposes within veterinary medicine. Our systematic review approach followed PRISMA guidelines, focusing on the intersection of DL and veterinary medicine, and identified 422 relevant research articles. After exporting titles and abstracts for screening, we narrowed our selection to 39 primary research articles directly applying …

A Turning Point In Cardiac Remodelling In Obesity: Obesity, Mariella R. Huaman, Carlos J. Toro-Huamanchumo

Research outputs 2022 to 2026

Cardiac remodelling in obesity has received growing attention in the past two decades, particularly as the prevalence of obesity continues to rise globally. In 2013, Aurigemma and colleagues published a seminal study that provided crucial insights into the structural changes in the heart associated with obesity. This study summarized advances in understanding how the disproportionate growth of adipose tissue affects cardiac function, and challenged and reshaped previously established paradigms. Before the publication of this report, the standard paradigm held that obesity-induced haemodynamic stress primarily drove eccentric left ventricular hypertrophy. However, this study instead demonstrated that in individuals with obesity, concentric …

Aboriginal, Torres Strait Islander And Māori Nursing And Midwifery Academic Workforce Across Australia And Aotearoa New Zealand, Ann Bonner, Linda Deravin, Jan Dewar, Moira Williamson, Kerri Gillespie, Cheryl Atherfold, Karen Nightingale, Caryn West, Karen Strickland

Research outputs 2022 to 2026

Background: Promoting a representative and supportive industry for Aboriginal, Torres Strait Islander and Māori nursing and midwifery academic staff is a key tenet of Australian and Aotearoa New Zealand universities, and fundamental to strengthening the health workforce. Surprisingly, information about this workforce is unknown. Aim: The aim of the study was to gain an understanding of the Aboriginal, Torres Strait Islander and Māori nursing and midwifery academic workforce. Methods: A cross-sectional study was conducted using an online survey of organisations that provide accredited nursing and midwifery education within Australia and Aotearoa New Zealand. Demographic, academic and employment information relating to …

Igg N-Glycosylation Contributes To Different Severities Of Insulin Resistance: Implications For 3p Medical Approaches, Xiaohong Chen, Lois Balmer, Kun Lin, Weijie Cao, Ziyu Huang, Xiang Chen, Manshu Song, Yongsong Chen

Research outputs 2022 to 2026

Background: Reliable biomarkers capturing immunometabolic processes in insulin resistance (IR) remain limited. IgG N-glycosylation modulates immune responses and reflects metabolic disorders, yet its role in IR remains unclear. This study investigated its potential for early detection, risk stratification, and targeted prevention within the framework of predictive, preventive, and personalised medicine (PPPM/3PM). Methods: A total of 313 participants were categorized into three groups based on the homeostatic model assessment for insulin resistance (HOMA-IR): insulin-sensitive (HOMA-IR < 2.69 without diabetes, n = 75), mild IR (HOMA-IR ≥ 2.69 without diabetes, n = 155), and severe IR (HOMA-IR ≥ 2.69 with type 2 diabetes, n = 83). Canonical correlation analysis was conducted to explore the overall relationship between IgG N-glycosylation and IR-related inflammation, indicated by tumour necrosis factor-α, interleukin- 6, C-reactive protein, and adiponectin. Mediation analysis was performed to evaluate the effect of IgG N-glycans on IR. Ordinal logistic regression was used to assess the association between IgG N-glycans and IR severity, with discriminative power evaluated using receiver operating characteristic curves. Results: Pro-inflammatory IgG N-glycoforms, characterized by reduced sialylation and galactosylation, along with increased bisecting N-acetylglucosamine, were observed as IR severity increased. IgG N-glycosylation significantly correlated with inflammatory markers in the insulin-sensitive (r = 0.599, p < 0.05), mild (r = 0.461, p < 0.05), and severe (r = 0.666, p < 0.01) IR groups. IgG N-glycosylation significantly influenced IR (β = 0.406) partially via modulation of inflammation. Increased glycoforms FA2[6]G1 (OR: 0.86, 95% CI: 0.78–0.96) and A2G2S2 (OR: 0.88, 95% CI: 0.82–0.94) were associated with a lower IR risk, with respective area under the curves (AUCs) of 0.752, 0.683, and 0.764 for the insulin sensitive, mild, and severe IR groups. Conclusions: IgG N-glycosylation contributes to IR by modulating inflammatory responses. Glycoforms FA2[6]G1 and A2G2S2 emerge as protective biomarkers, offering potential for predicting and preventing IR through primary prevention strategies within the PPPM framework.

Investigating Protective And Risk Factors And Predictive Insights For Aboriginal Perinatal Mental Health: Explainable Artificial Intelligence Approach, Guanjin Wang, Hachem Bennamoun, Wai Hang Kwok, Jenny Paola Ortega Quimbayo, Bridgette Kelly, Trish Ratajczak, Rhonda Marriott, Roz Walker, Jayne Kotz

Research outputs 2022 to 2026

Background: Perinatal depression and anxiety significantly impact maternal and infant health, potentially leading to severe outcomes like preterm birth and suicide. Aboriginal women, despite their resilience, face elevated risks due to the long-term effects of colonization and cultural disruption. The Baby Coming You Ready (BCYR) model of care, centered on a digitized, holistic, strengths-based assessment, was co-designed to address these challenges. The successful BCYR pilot demonstrated its ability to replace traditional risk-based screens. However, some health professionals still overrely on psychological risk scores, often overlooking the contextual circumstances of Aboriginal mothers, their cultural strengths, and mitigating protective factors. This highlights …

Psychosocial Workplace Hazards And Industrial Relations: An Introduction, Alexis Vassiley, Tom Barratt, Kantha Dayaram, John Burgess

Research outputs 2022 to 2026

This article introduces the special issue, bringing together research on psychosocial workplace hazards (PSWH) which engages industrial relations (IR) perspectives. This is important as PSWH are increasingly studied and regulated, with new regulatory frameworks creating opportunity and necessity for IR perspectives to engage with PSWH. These hazards are intimately related to power relations between employers, workers and the broader society within which they interact, a topic of longstanding investigation within IR. To date, PSWH research has largely occurred in the work, health and safety (WHS) field, reflecting a broader historical separation between WHS and IR in scholarship and practice. While …

Reduced Achilles Tendinopathy Symptoms (E.G. Stiffness), But Not Pain, Relate To Patient-Perceived Resolution Of Achilles Tendinopathy: A Cross-Sectional Study, Myles C. Murphy, Fletcher Bright, George White, Ruth L. Chimenti, Andrea B. Mosler, Ebonie K. Rio

Research outputs 2022 to 2026

We aimed to determine whether pain, symptoms and/or physical function are associated with perceived recovery in people with current or resolved Achilles tendinopathy. We performed a cross-sectional cohort study, including people who reported having either “current” or “resolved” Achilles tendinopathy. Participants completed an online survey, including the Tendinopathy Severity Assessment- Achilles (TENDINS-A). We used multivariable binary logistic regression and reported odds ratio (OR) to quantify the strength of the association. We included 100 cases (n = 63 current, n = 37 resolved). There were no associations of age, sex, BMI, TENDINS-A (Pain) or TENDINS-A (Physical Function) with whether participants reported …

The Csr Practices Of Western Australian Mining Based On Innovation Ecosystems: Pathways To Collaborative Innovation And Sustainable Development, Jiawei Sun

Research outputs 2022 to 2026

This study investigates the Corporate Social Responsibility (CSR) practices of Western Australian mining companies, focusing on their integration of innovation ecosystems to promote sustainable development. Through case studies of BHP Group, Rio Tinto, FMG, and South32, the research examines how these companies reduce carbon emissions, enhance community development, and foster collaborative innovation. The findings highlight the significant role of innovation ecosystems in enabling these companies to adopt cleaner technologies, improve social outcomes, and maintain a competitive edge in a sustainability-conscious global market. The study also explores the challenges and opportunities faced by mining companies in leveraging collaborative innovation to address …

Anticodon-Edited Trna Enables Translational Readthrough Of Col4a5 Premature Termination Codons, Kohei Omachi, Joseph J. Porter, John D. Lueck, Jeffrey H. Miner

2020-Current year OA Pubs

Alport syndrome is caused by variants in COL4A3, COL4A4, or COL4A5, which encode the α3α4α5 chains of type IV collagen. These variants result in defects in the glomerular basement membrane (GBM) and impaired kidney function. Nonsense variants result in truncated proteins lacking the NC1 domain, thereby preventing proper GBM assembly and function and causing the most severe forms of the disease. Restoring full-length protein expression represents a potential therapeutic strategy for Alport syndrome and related disorders. Anticodon-edited transfer RNAs (ACE-tRNAs), which promote premature termination codon (PTC) readthrough, have shown promise in diseases such as cystic fibrosis, but their application in …

Ability In Physical Education – No, I Can’T Discuss It! Insights From Lower Secondary Physical Education Teachers In Western Australia, Jeffrey Giles, Dawn Penney, Justen O’Connor

Research outputs 2022 to 2026

Ability has been positioned as a crucial concept in the construction of a subject that is inclusive of and meaningful for all students. Almost two decades since Evans (2004) called on the field to re-engage in discourse concerning ability, how ability is conceptualised by physical education (PE) teachers remains relatively unexplored. Furthermore, relatively little is known about how understandings of ability are enacted through curriculum, pedagogy and assessment in PE. This research explored these issues with lower secondary PE teachers in Western Australia through self-recorded audio responses to two research questions. Data from 38 participants revealed the struggles that PE …

Supporting People Bereaved By Suicide In The South West Region Of Western Australia: Report, Colleen M. Carlon

Research outputs 2022 to 2026

This paper reports on the practices of service providers in working with people and communities bereaved by suicide in regional contexts. For people bereaved by suicide experiences of grief, trauma and stigma and the questioning of why someone has died create a complex mix of need and emotion that can leave people vulnerable to complicated grief and poor physical and mental health. These effects may also be exacerbated by stigma in social and communal contexts. As such experiences of suicide grief are different to other forms of grief and loss, effectively supporting people and communities bereaved by suicide requires knowledge …

Comusichiamo. First Language, Life-Soundtracks And Storytelling To Support The Cultural Wellbeing Of Migrants Living With Dementia, Simone Marino, Loretta Baldassar

Research outputs 2022 to 2026

This study, located at the intersection of anthropology, ageing, music therapy and dementia, explores the value of music, life-storytelling and first language, to support the cultural identity and wellbeing of people from culturally and linguistically diverse backgrounds living with dementia in Australia. It uses participant observation, the collection of oral histories and ‘life soundtracks’ to co-create a song with older Italian migrants and their families. This paper presents the first case study which informed the development of the music engagement program we call Comusichiamo (let’s make music together). The case study shows that the co-creation of a culturally tailored song, …

Cultural Influences, Experiences And Interventions Targeting Self-Management Behaviours For Prediabetes Or Type 2 Diabetes In First-Generation Immigrants: A Scoping Review, Min Zhang, Kirsten Coppell, Johnny Lo, Lisa Whitehead

Research outputs 2022 to 2026

Aim: To map the existing evidence and identify research gaps regarding the self-management of prediabetes or type 2 diabetes among first-generation immigrants ≥ 18 years. Design: A scoping review followed the JBI guidelines and was in accordance with the PRISMA extension for Scoping Reviews. Methods: A systematic search of CINAHL, Cochrane, EMBASE, MEDLINE, PsycINFO, ProQuest, SCOPUS and the Web of Science was conducted. Grey literature and reference lists of included studies were searched for additional citations. Articles published in English from the database inception to February 2023 were included. Results: We included 96 studies, of which 28.1% were published within …

Principals And The Careless Erosion Of Employment Standards In The Context Of School Autonomy And Marketisation: A Case Study Of School Support Staff, Brad Gobby, Jill Blackmore, Scott Eacott, Amanda Keddie, Katrina Macdonald, Richard Niesche, Jane Wilkinson

Research outputs 2022 to 2026

Devolved governance, school autonomy and marketisation impact the employment practices of schools and the working conditions of teachers. However, the employment-related effects on school services staff are under-researched. This study draws on data from interviews with staff at one public high school to analyse school services staff experience of school autonomy and the employment practices of principals in the context of competitive education markets. This case study illustrates how a principal's management of employment and labour relations in a school experiencing declining enrolments and reduced resources impacted the labour and working conditions of school services staff. We argue that the …

The Influence Of Project Managing Capability, It Integration, Supply Coordination, And Process Innovation To Improve Organizational Performance Of Educational Institutions, Ellysa Sri Hartati, Hotlan Siagian, Zeplin Jiwa Husada Tarigan, Ferry Jie

Research outputs 2022 to 2026

The organization strives to provide timely service according to customer needs. Organizations must communicate and make the right decisions quickly to improve performance. The research aims to assess the influence of project management capability, integration, and coordination in improving organizational performance. Data is collected using a questionnaire designed with a five-point Likert scale. The respondents are all suppliers or vendors of high school educational Institutions in East Java. The organization has a project manager responsible for all procurement and projects. The criteria of suppliers or vendors are those who have paid taxes, have a taxpayer number, and have an adequate …

Flexible Furniture To Support Inclusive Education: Developing Learner Agency And Engagement In Primary School, Julia E. Morris, Wesley Imms

Research outputs 2022 to 2026

To ensure quality and equitable education requires an understanding of how all learners function within a learning environment, and the ways in which teachers’ pedagogy can support inclusive practice. Drawing on research from a rural school in Western Australia, this paper identifies how furniture can be used as a tool to support student agency and opportunity to meet individual learning needs. Across two years, the study employed a single-subject research design to explore the impact of differing furniture arrangements on students’ agency and engagement, as well as teacher pedagogies. It used both quantitative and qualitative repeated measures with 9 teachers …

The Relationship Between The Mental Health Of Refugee Parents And Their Children: An Investigation Of Australian Longitudinal Data, Katie Tills, Justine Dandy

Research outputs 2022 to 2026

We investigated the relationship between parent and child mental health, including parents’ general psychological distress, among refugees resettled in Australia. We utilised longitudinal data from a sample (N = 602 children and 377 parents) of recently settled refugees from the Building a New Life in Australia Survey). Parent psychological distress and post-traumatic stress symptoms (PTSS) were measured by the Kessler 6 and PTSD-8, respectively. Harsh and Warm parenting behaviours were also measured to explore the mechanisms underlying the parent-child mental health relationship. Child mental health was measured using the SDQ. Using path analysis, we found that increases in parent psychological …

Transnational Grandparent Migration And Care-Giving: A Systematic Scoping Review, Hien Thi Nguyen, Catriona Stevens, Loretta Baldassar

Research outputs 2022 to 2026

Grandparents are increasingly participating in international migration to resettle with or visit adult children and grandchildren living overseas. In doing so, they make important social, cultural, emotional and financial contributions to transnational families, in particular through providing unpaid childcare and domestic work. This scoping review aims to examine the extent, range and nature of studies on transnational grandparent migration and care-giving to provide an overview of existing research. The review was conducted in August 2022, following Arksey and O’Malley’s scoping review methodology. Of 2,099 sources identified using nine databases, supplemented with manual searching (including grey literature), 65 (qualitative, quantitative and …

Young Children Moving Through Ecological Anxiety And Grief: Dancing With Demolition, Jane Merewether, Jo Pollitt, Mindy Blaise

Research outputs 2022 to 2026

As the extent of planetary unraveling becomes increasingly apparent, scholars are beginning to document responses to the loss of ecological systems, mass extinctions, and climate change. However, there are few studies documenting children’s eco-anxiety responses. In this study, children’s eco-anxiety and grief became apparent when they expressed dismay at the imminent demolition of a derelict building. Children were concerned for the fate of the building, the land on which it stood, and the myriad others it sheltered. Using participatory and creative methodologies including dance, this project worked with children to tell a more-than-human story of becoming-with children-building-weeds-graffiti-dust-researchers-unhoused-bacteria-rats-and unloved others, which …

Practices And Perceptions In Hamstring Training For Injury Risk Mitigation: A Survey-Based Mixed-Methods Analysis, Steven Ross, Nicholas J. Ripley, John J. Mcmahon, Paul Comfort

Research outputs 2022 to 2026

In this study, the practices and perceptions of sport and exercise practitioners regarding hamstring training for injury risk mitigation were investigated. Hamstring strain injuries (HSIs) remain a prevalent issue across sports, despite extensive research. An anonymous survey was conducted to assess how practitioners integrate evidence-based strategies, such as the Nordic hamstring exercise (NHE) and high-speed running (HSR), into their training programmes. The survey included both fixed-response and open-ended questions, enabling a mixed-methods analysis of training approaches. A total of 47 practitioners responded, revealing that most incorporate the NHE and HSR into both in-season and off-season training. However, there were notable …

Rapid Weight Loss Across Combat Sports And The Relationships Between Methods And Magnitude, Oliver R. Barley, Craig A. Harms

Research outputs 2022 to 2026

This study examined rapid weight loss (RWL) habits across combat sports (CS) and how common usage of different methods was related to the magnitude of RWL. Competitors (N = 256) from CS including boxing, Brazilian jiu-jitsu, muay thai/kickboxing (MT/KB), wrestling, mixed martial arts (MMA), judo, taekwondo, and karate participated in the study. Athletes completed an online survey which included questions on their regular weight loss habits, including magnitudes of weight loss over different time periods and types of methods utilised. Athletes typically started losing weight in their early 20s and engaged in RWL on average three times a year. Magnitudes …

School Infrastructure Procurement By Public–Private Partnership: In The Public Interest?, Leon Benade

Research outputs 2022 to 2026

The use of Public–Private Partnerships (PPPs) in the education sector to construct and maintain schools’ infrastructure is under-researched by Educational Studies specialists. This article presents an assay of the use of PPP to procure school facilities, notably in developed contexts, where PPP arrangements are typically a product of the neoliberal privatisation of education. PPP arrangements allow governments to contract private sector partners to finance, design and construct school facilities infrastructure in exchange for state payments. The evaluation is complemented by a critical analysis of the WA Schools Public Private Partnership Project and three published Australian-based case studies. This sets the …

Sleep In Residential Aged Care: A Secondary Qualitative Analysis Of Data From The Australian Royal Commission Into Aged Care Quality And Safety, Aisling Smyth, Patricia Cain, Sabine Pangerl, Christopher Gordon, Kasia Bail, Davina Porock

Research outputs 2022 to 2026

Background:

Sleep is a crucial healing and restorative component of older person care but is often negatively impacted through the effects of institutionalization in residential aged care (RAC). Currently, information about how sleep occurs is limited.

Methods:

Through the lens of person-centered care, this study examined submissions to the Australian Royal Commission into Aged Care Quality and Safety. The Commission was established in 2018 with the aim of protecting and improving the safety, quality of life, and well-being of people receiving aged care. The commission received 10 000+ submissions from a range of stakeholders, including consumers, family members, expert witnesses, …

Sports Metaresearch: An Emerging Discipline Of Sport Science And Medicine, John Warmenhoven, Paolo Menaspà, David N. Borg, Simine Vazire, Nicole White, Kristin Sainani, Sophia Nimphius, Aaron J. Coutts, Franco M. Impellizzeri

Research outputs 2022 to 2026

Inadequacies in the conduct and quality of research are well established across many research domains, including sport science and medicine. Metaresearch—the practice of performing research on research—is presented as a practical vehicle for improving research quality through evaluating the research processes. This article introduces the concept of metaresearch to sport as a new sub-field of sport science. The broad types of metaresearch are introduced, with a mapping of current sports metaresearch activity across these areas. Interdisciplinary centres aimed at improving scientific quality across other fields are also introduced to sport, and specific considerations for beginning metaresearch are provided for sport. …

Survival After Cessation Of Immunotherapies In Melanoma: A Systematic Review And Meta-Analysis, Kristine E. Mayer, Lydia Warburton, Anne Zaremba, Sarah Preis, Yannick Foerster, Tilo Biedermann, Oana Diana Persa

Research outputs 2022 to 2026

Background: Immune-checkpoint inhibitor (ICI) therapy elicits durable responses in a subset of patients with advanced melanoma. However, the appropriate timing for treatment cessation remains an unresolved issue. Moreover, some patients are required to discontinue therapy due to the occurrence of severe adverse events. Upon treatment cessation, a subset of patients maintains a durable response, while some patients relapse and require rechallenge with ICI. Criteria for a safe stop of ICI have not been established. Objectives: The aim of this systematic review and meta-analysis was to evaluate the durability of response in melanoma patients who discontinued ICI therapy. Furthermore, the outcome …