Digital Commons Network^™

Inflammatory Mediators And The Rage Pathway In Placental Tissues Of Pregnancies Complicated By Severe Preeclampsia, Neelima Chandra, Thomas D. Kimble, Kathleen R. Heim, Sharon M. Anderson, Andrew P. Wong, Andrea R. Thurman, Gustavo F. Doncel

CONRAD Publications

Introduction: Preeclampsia (PE) is a complex multisystem disorder of pregnancy associated with abnormal placentation, vascular anomalies, and systemic inflammation and hypertension. Previous research assessing inflammatory triggers of the condition used plasma, amniotic fluid, or explant samples. Studies using placental tissue from either vaginal or cesarean deliveries are confined to semiquantitative analysis using subjective scoring methods and generally involve a small sample size.

Methods: In this study, we have quantified the expression of inflammatory mediators by immunohistochemical image analysis of archived placental tissues obtained from cesarean delivery of preeclamptic, chorioamnionitic, and normal pregnancies.

Results: Among the inflammatory mediators, we found a …

Synthesis And Evaluation Of Anti-Hiv Activity Of Fatty Acyl Conjugates Of Tenofovir Alefanamide, Muhammad Sajid, Naglaa Salem El-Sayed, Louise A. Ouattara, Amita Verma, Gustavo F. Doncel, Keykavous Parang, M. Iqbal Choudhary, Hina Siddiqui

CONRAD Publications

The activity of nucleoside and nucleotide analogs as antiviral agents requires phosphorylation by intracellular enzymes. Phosphate-substituted analogs have low bioavailability due to the presence of ionizable negatively-charged groups. To circumvent this limitation, several prodrug approaches have been proposed and developed. Herein, we hypothesized that the conjugation of anti-HIV fatty acids with the nucleotide tenofovir alafenamide (TAF) (1) could improve the anti-HIV activity of the nucleotide. Several fatty acyl amide conjugates of TAF were synthesized and evaluated in comparative studies with TAF. The synthesized compounds were evaluated as racemic mixtures for anti-HIV activity in vitro in a single-round HIV-1 infection assay …

What Is The Optimal Management Of Metastatic Spine Patients With Intermediate Spinal Instability Neoplastic Scores: To Operate Or Not To Operate?, William Chu Kwan, Matthew L Goodwin, Et Al.

2020-Current year OA Pubs

STUDY DESIGN: Systematic review.

OBJECTIVE: In patients with extradural metastatic spine disease, we sought to systematically review the outcomes and complications of patients with intermediate Spinal Instability Neoplastic Score (SINS) lesions undergoing radiation therapy, percutaneous interventions, minimally invasive surgeries, or open spinal surgeries.

METHODS: Following PRISMA guidelines for systematic reviews, MEDLINE, EMBASE, Web of Science, the Cochrane Database of Systematic Reviews and the Cochrane Center Register of Controlled Trials were queried for studies that reported on SINS intermediate patients who underwent: 1) radiotherapy, 2) percutaneous intervention, 3) minimally invasive, or 4) open surgery. Dates of publication were between 2013-22. Patients …

Overview Of Molecular Prognostication For Common Solid Tumor Histologies - What The Surgeon Should Know, C Rory Goodwin, Matthew L Goodwin, Et Al.

2020-Current year OA Pubs

STUDY DESIGN: Narrative Literature review.

OBJECTIVE: To provide a general overview of important molecular markers and targeted therapies for the most common neoplasms (lung, breast, prostate and melanoma) that metastasize to the spine and offer guidance on how to best incorporate them in the clinical setting.

METHODS: A narrative review of the literature was performed using PubMed, Google Scholar, Medline databases, as well as the histology-specific National Comprehensive Cancer Network guidelines to identify relevant articles limited to the English language. Relevant articles were reviewed for commonly described molecular mutations or targeted therapeutics, as well as associated clinical outcomes, and surgery-related …

Rfid Occupied Advanced Framework For Specialized Vehicle Access, Operating System, And Wireless Data Transmission Without Human Intervention, Abdullah Al Mamun Anik, Mosammet Sadia Akter Moon, Fahim Faysal Arnob, Mehedi Hasan, S. A. Naimal Hoque, Mohammad Mashhunar Rahman, Tahzin Bin Ahmed, Tonmoy Barua

Mechanical Engineering Faculty Publications and Presentations

Radio frequency identification system (RFID) tags are tiny electronic devices that include a distinctive code that can be detected by a reader that supports RFID. The string of characters is used for recognizing and monitoring the object to which the tag is connected. RFID tags interact with RFID readers using radio frequency. While the tag comes into close proximity to the scanner, that device sends a radio signal that triggers the tag. The tag then responds by sending its unique identity. RFID pinpointing ability is verified experimentally in two different techniques, one utilizing radar and the other a photosensitive transition. …

Draft Final Silver Bow Creek Conservation Area Repository Data Gap Data Summary Report (Dsr), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

This Silver Bow Creek Conservation Area (SBCCA) Repository Data Gap Data Summary Report (DSR) presents the results from the soil sampling activities conducted as specified in the SBCCA Repository Data Gap Quality Assurance Project Plan (QAPP) (referred to herein as the SBCCA Repository Data Gap QAPP; Atlantic Richfield Company, 2024). The information presented in this DSR includes laboratory analytical results from subsurface soil sampling collected from Buffalo Gulch (BG), Butte Reduction Works (BRW), Diggings East (DE), and Northside Tailings (NST) within the SBCCA. This DSR was prepared by Pioneer Technical Services, Inc. (Pioneer), 1101 S. Montana Street, Butte, Montana 59701 …

Revised Final Multi-Pathway Residential Metals Abatement Program Plan, Atlantic Richfield Company, Butte Silver Bow

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Schistosomiasis Interventions In Africa: Assessment And Systematic Review, Christopher Yaw Dumevi, George Boateng Kyei, Patience B Tetteh-Quarcoo, James-Paul Kretchy, Irene Ayi, Patrick F Ayeh-Kumi

2020-Current year OA Pubs

No abstract provided.

Protocol For The Asian Cohort For Alzheimer's Disease (Acad) Study, Pei-Chuan Ho, Walter A Kukull, Et Al.

2020-Current year OA Pubs

INTRODUCTION: To address knowledge gaps in Alzheimer's disease (AD) research, the Asian Cohort for Alzheimer's Disease (ACAD) Study will recruit over 5000 participants of Asian descent aged 60 or older in the United States and Canada. The current focus is on participants with Chinese, Korean, or Vietnamese ancestry, with the goal of characterizing both genetic and non-genetic risk factors. ACAD has assembled a culturally and linguistically appropriate data collection protocol, as well as a biosample collection protocol. Recruitment strategies follow community-based participatory research (CBPR) approaches to encourage research participation and engage Asian communities in brain health education.

METHODS: The ACAD …

Domain-Specific Customization For Language Models In Otolaryngology: The Ent Gpt Assistant, Brenton T Bicknell, Nicholas J Rivers, Adam Skelton, Delaney Sheehan, Charis Hodges, Stevan C Fairburn, Benjamin J Greene, Bharat Panuganti

2020-Current year OA Pubs

OBJECTIVE: To develop and evaluate the effectiveness of domain-specific customization in large language models (LLMs) by assessing the performance of the ENT GPT Assistant (E-GPT-A), a model specifically tailored for otolaryngology.

STUDY DESIGN: Comparative analysis using multiple-choice questions (MCQs) from established otolaryngology resources.

SETTING: Tertiary care academic hospital.

METHODS: Two hundred forty clinical-vignette style MCQs were sourced from BoardVitals Otolaryngology and OTOQuest, covering a range of otolaryngology subspecialties (n = 40 for each). The E-GPT-A was developed using targeted instructions and customized to otolaryngology. The performance of E-GPT-A was compared against top-performing and widely used artificial intelligence (AI) LLMs, including …

Review Of Marginality And Global Lgbt Communities: Conflicts, Civil Rights, And Controversy, Patrick Barchett

Nebraska Anthropologist

Review of Marginality and Global LGBT Communities: Conflicts, Civil Rights, and Controversy (2020) by Sheri R. Notaro.

Making Headway On Sports Concussion: Sport-Specific Strategies For Concussion Prevention, Marcus Moore

All Faculty Publications

Concussions in sports are a significant public health concern worldwide. Concussion is a traumatic brain injury (‘TBI’) resulting from biomechanical forces transmitted to the head that disrupt normal neurological function. Globally, an estimated 69 million TBIs occur annually. Concussive effects can persist as long-term syndromes (post-concussion syndrome), or compound themselves into life-threatening emergencies (second-impact syndrome). Chronic, even subconcussive, impacts can ultimately lead to degenerative neurological conditions (chronic traumatic encephalopathy). Troublingly, to date, there remains no medical cure for concussions. Prevention is thus paramount, as well as management, to avoid the compounding of injury or dangerous complications, as noted. Sports and …

Environmentally Friendly Chelation For Enhanced Algal Biomass Deashing, Agyare Asante, George Daramola, Ryan W. Davis, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

High ash content in algal biomass limits its suitability for biofuel production by reducing combustion efficiency and increasing fouling. This study presents a green deashing strategy using nitrilotriacetic acid (NTA) and deionized (DI) water to purify Scenedesmus algae, which was selected for its high ash removal potential. The optimized sequential treatment (DI, NTA chelation, and DI+NTA treatment at 90–130 °C) achieved up to 83.07% ash removal, reducing ash content from 15.2% to 3.8%. Elevated temperatures enhanced the removal of calcium, magnesium, and potassium, while heavy metals like lead and copper were reduced below detection limits. CHN analysis confirmed minimal …

Laboratory Investigation Of Shape And Initial Orientation Effects On Surf Zone Object Migration, Temitope E. Idowu, Jack A. Puleo

Civil & Environmental Engineering Faculty Publications

Discarded objects like munitions in marine environments pose public safety risks. The behavior of various density objects deployed at four cross-shore positions in the surf zone of a large-scale 120 m x 5 m x 5 m wave flume were observed under different forcing conditions. Net migration was predominantly directed offshore, with approximately 70 % offshore migration observed near the outer surf zone. Density, shape, and initial orientation were identified as important to object behavior, with density acting as the dominant driver in 67 % of the object pairing scenarios. The influence of shape and initial orientation on net migration …

Streamlining Wildlife Regulation, Robert L. Fischman

Articles by Maurer Faculty

A recent burst of revisions in the bedrock regulations governing projects that may adversely affect wildlife represents a generational shift in policy. Streamlining federal decision -making drove much of this reform. Streamlining offers a path to address climate change without abandoning a longstanding commitment to wildlife conservation. The conservation community recognizes the need to build new infrastructure to reduce the rate of climate change through air emissions. The most urgent priority is decarbonizing the electrical ~rid through renewable energy generation and a better transmission network. Adaptation to the "new abnormal" of climate-driven environmental disruption demands federal approvals for a host …

Data Injustice In Global Justice, Asaf Lubin, Cherry Tang

Articles by Maurer Faculty

In May 2020, the United Nations Secretary-General unveiled a sweeping “Data Strategy for Action by Everyone, Everywhere,” seeking to unlock the UN’s “full data potential.” The International Criminal Court’s Office of the Prosecutor followed suit, declaring in 2023 its intent to acquire advanced cyber forensic tools so as to hold the “widest range of digital evidence globally.” Across international institutions, data-driven governance has become the norm, with humanitarian agencies and tribunals transforming into “data hubs and information clearinghouses.” This Article critiques the unfettered datafication of global justice by international courts and organizations. These entities have aggressively expanded their data-driven operations …

Climate Prosecution As Climate Regulation, Cindy J. Cho

Articles by Maurer Faculty

Last term, the Supreme Court weakened the federal government’s ability to regulate. Three new decisions—and one landmark case from the previous term—will affect everything from drug approvals to overtime pay to national security. One issue stands out as a political flashpoint that will prove particularly difficult to address via regulation in the wake of this term: climate change. Given the unlikelihood of congressional climate action any time soon, those concerned about the risks of a warming planet will no doubt be looking for alternatives to regulation. Private and state civil lawsuits against polluters reflect an important legal tradition that must …

Reconstituting Corporate Power & Accountability, Cindy J. Cho, Donald Braman, Theresa Gabaldon

Articles by Maurer Faculty

Modern society faces a growing crisis of corporate impunity. While corporations generate immense value, they increasingly inflict harm at scales that dwarf those of traditional street crime. Decades of deregulation, unchecked corporate lobbying, and a judiciary actively dismantling the administrative state have created a dangerous accountability vacuum. And just as federal oversight is collapsing, the Supreme Court's expanding preemption doctrine is handcuffing state regulators. This Article proposes a paradigm shift: the revitalization of state criminal authority, a power largely shielded from federal interference. Upon securing a conviction or deferred prosecution agreement, states should mandate that the offending corporation conduct all …

Testing The Antigenic Potential Of Transmembrane Proteins To Develop A Thermostable Tuberculosis Mof-Liposomal Vaccine, Sneha Kumari, Jonathan Martinez-Garcia, Ryanne Nicole Ehrman, Wendy Tang, Joshua Miles, Priyanka Basak, Thomas Sinclair Howlett, Yalini Hansika Wijesundara, Ziqi Wang, Blanca I. Restrepo

School of Medicine Publications

Tuberculosis is one of the deadliest infectious diseases and continues to be a major health risk in many parts of the world. Even today, the century-old Bacillus Calmette-Guerin (BCG) vaccine is the only formulation on the market and is ineffective for several sections of the global population responsible for transmission. In the search for antigens that can mount a robust immune response, we have reported the recombinant expression and purification of two novel membrane proteins, the Cation transporter protein V (CtpV) and the Mycobacterial copper transporter B (MctB) present on the membrane surface of Mycobacterium tuberculosis. CtpV was tested …

Clinical Criteria For Limbic-Predominant Age-Related Tdp-43 Encephalopathy, David A. Wolk, Peter T. Nelson, Liana Apostolova, Konstantinos Arfanakis, Patricia A. Boyle, Cynthia M. Carlsson, Nick Corriveau-Lecavalier, Penny Dacks, Bradford C. Dickerson, Gladys E. Maestre

School of Medicine Publications

Limbic predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is highly prevalent in late life and a common co-pathology with Alzheimer's disease neuropathologic change (ADNC). LATE-NC is a slowly progressive, amnestic clinical syndrome. Alternatively, when present with ADNC, LATE-NC is associated with a more rapid course. With the emergence of anti-amyloid therapeutics, discrimination of LATE-NC from ADNC is critical and will lead to greater clinical recognition of amnestic patients without ADNC. Furthermore, co-pathology with LATE-NC may influence outcomes of these therapeutics. Thus there is a need to identify patients during life with likely LATE-NC. We propose criteria for clinical diagnosis of …

Clinical Relapse Versus Treatment Failure: The Case For Surveillance For Re-Appearance Of Minimal Measurable Disease In Pediatric Patients With Higher Risk B-All, Paul S. Gaynon, Linwei Li

School of Medicine Publications

No abstract provided.

Coming Out To My Christian Loved Ones: Online Workshop Effectiveness For Increasing Lgbtq+ Individuals And Lgbtq+ Ally Communication Efficacy And Impacts On Personal-Enacted Identity Gaps, Samantha Renee Leggett-Bradley

Graduate Theses, Dissertations, and Problem Reports (ETD)

It is not uncommon for passages from the Christian Bible to produce schisms in families, friendships, mentorships, workplace relationships, individual churches, and denominations. These challenging conversations are often around LGBTQ+ topics. Many marginalized LGBTQ+ individuals and allies in these spaces become outgroup members who feel insecure and less confident enacting aspects of their own identities or identities they support. A lack of communication efficacy for how to navigate LGBTQ+ related conversations with Christian loved ones may lead to detrimental physical, mental, and emotional outcomes.

This study surveyed 134 LGBTQ+ individuals and allies as well as conducted semi structured interviews with …

Essays On Application Of Machine Learning To Financial Statement Fraud, Lin Xia

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation is composed of two studies, both of which revolve around the application of machine learning to financial statement fraud. The first study entitled, “Complementary Role of Algorithm and Theory for Financial Statement Fraud” investigates the nature of relationship of theory building research and machine learning algorithms. Recent research on financial statement fraud has seen an increase in the use of machine learning techniques. While some machine learning based studies build on variables from causal inference research, others claim that machine learning algorithms work better with raw accounting variables and thus cast doubt on the role of …

How Do The Commitments Required To Be An Agricultural Education Teacher Impact The Children Of Female Agricultural Education Teachers As Perceived By Their Children?, Danielle Nicole Grant

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study is to explore how adult children of women agricultural education teachers articulate their experiences growing up with their mother working in the agricultural education field. This will be examined through the following research. The phenomenological study focused on the perceptions of five adult children of female agricultural education teachers in a single state. The research was conducted through recorded virtual interviews with a targeted list of pre-determined questions. Five themes emerged after utilizing Colaizzi’s phenomenological method of analysis: 1) Mother’s Commitment to Implementing the Three Circle Model, 2) The Need for Outside “Maternal” Role Assistance, …

Racial And Ethnic Threat And The Accessibility Of The Legal Recreational Cannabis Market In California, Kathryn L. Burnham

Graduate Theses, Dissertations, and Problem Reports (ETD)

Racial and Ethnic Threat and the Accessibility of the Legal Recreational Cannabis Market in California

By Kathryn L. Burnham

Drug prohibition has a racialized history in the United States (US). Cannabis became synonymous with the perceived enhanced criminality of Black and Hispanic populations by the White public. Despite similar prevalence of cannabis use among people who are Black, White, and Hispanic, the vilification and stigmatization of Black and Hispanic cannabis users began in the early 1900s and continued for over a century. As individual states continue to legalize cannabis use and public opinion favors the federal legalization of cannabis, it …

Tree Crown Economics Of Broadleaf Deciduous Forests, Yiting Fan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Tree crown architecture, a critical determinant of forest ecosystem processes such as photosynthesis, evapotranspiration, and spectral reflectance, is shaped by adaptive trade-offs in resource use and environmental responses. However, significant gaps remain in our understanding of how these traits vary across species, environmental gradients, and temporal scales. This dissertation addresses these gaps by employing remote sensing data across three interconnected studies. Together, these studies advance tree crown economic theory, highlighting how crown traits mediate trade-offs between light capture and water-use efficiency and how these traits influence forest responses to global change. Collectively, this dissertation offer insights for improving models that …

A Sense Of Purpose In Life And Efforts To Increase It In Higher Education, Jacob Edwin Alderson

Graduate Theses, Dissertations, and Problem Reports (ETD)

A sense of purpose in life, defined as a dispositional tendency to pursue goals and activities in line with one’s overarching life direction (Hill, 2016), has been discussed as a key individual difference factor to foster in today’s college students (Colby, 2020; Pfund, Bono, & Hill, 2020). As such, the present dissertation sought to understand the psychosocial and academic benefits associated with having a sense of purpose in life in college via two studies: 1. Assessing changes in a sense of purpose in life across the first year of college and how these changes were associated with academic performance and …

Beyond My Control: The Role Of Sense Of Control On Cognitive Functioning And Depressive Symptoms In Older Adults, Sabine Lohmar

Graduate Theses, Dissertations, and Problem Reports (ETD)

Depression and depressive symptoms commonly coincide with mild cognitive impairment (MCI) and dementia in older adults (Ismail et al., 2017; Panza et al., 2010), with its prevalence varying based on dementia severity, diagnostic criteria, and dementia subtype (Chi et al., 2015; Ismail et al., 2017; Leung et al., 2021; Lopez et al., 2003). This relationship is hypothesized to exist for a variety of reasons, including that depressive symptoms occur as an emotional response to cognitive functioning (Bennett & Thomas, 2014; Richard et al., 2013). Emotional responses may be explained by a decline in sense of control, or the belief in …

Girl Gamers, Online Community, And Social Identity Theory: The Role Of Positive Distinction Strategies On Group Engagement On R/Girlgamers, Rachael Green

Graduate Theses, Dissertations, and Problem Reports (ETD)

Identity theorists have studied the complex relationship between gender and gaming for over two decades, but research on how women persist in gaming communities despite harassment remains underdeveloped. Grounded in Social Identity Theory, this dissertation examines the subreddit r/GirlGamers to evaluate the prevalence and impact of positive distinction strategies in countering identity threats. Based on a mixed-methods approach, the findings highlight three key strategies (group permeability, social creativity, and social competition) alongside themes of emotion, structural inequality, and interpersonal violence. Statistical tests indicate that posts employing at least one positive distinction strategy receive significantly more upvotes and comments than those …

An Intersectional Approach To Examining The Impact Of Cigarette Taxes On Tobacco Use By Urbanization Level, Andrea R. Milstred

Graduate Theses, Dissertations, and Problem Reports (ETD)

Rates of traditional tobacco use have reached a century-level low though not universally with some vulnerable populations continuing high rates of tobacco use, such as those located in geographically isolated areas of the United States (US). Rural populations experience a unique set of challenges (i.e., decreased access to health promoting resources, high density of tobacco retailers, increased pro-tobacco advertising) that compound to produce a “cumulative disadvantage” ultimately increasing their risk of tobacco use. To curb and prevent tobacco use, tobacco control policies, such as excise taxes, can be implemented. At least one study suggests tobacco control policies are less effective …