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Assessing Arbuscular Mycorrhizal Fungal Community Composition And Diversity Across A Land-Use Gradient In Eastern Washington Prairies, Katherine I. Cole

EWU Masters Thesis Collection

Arbuscular mycorrhizal fungi (AMF) are key to healthy, functioning terrestrial ecosystems worldwide. Associating with over 80% of all extant land plants, they play a pivotal role in nutrient cycling, and contribute to overall plant health. Given their significance to terrestrial ecosystems, AMF have a crucial role to play in the successful restoration of Eastern Washington’s native prairies. However, AMF community composition is significantly altered by the commercial agricultural practices used extensively in this region for over 100 years. The Eastern Washington University (EWU) Prairie Restoration Project aims to restore ~120 acres of farmland to native prairie. This research provides insight …

Supporting Social Justice In Physical Education Teacher Education Programs: A Qualitative Analysis Of Adapted Pe Teachers' Perspectives, Ann-Catherine Sullivan, Christianna Blanchard-Alworth, Cynthia K. Piletic, Linda Hilgenbrinck

Educational Leadership & Workforce Development Faculty Publications

Despite attention to sociocultural issues in Physical Education Teacher Education (PETE), the role of Adapted Physical Education (APE) teachers as social justice advocates remains underexplored. A primary responsibility of APE teachers is to provide specially designed instruction to students with disabilities (SWD), so they have access to the general physical education curriculum to make progress toward grade-level standards. This study presents a qualitative analysis of the perspectives of National Adapted Physical Education Teachers of the Year (APE TOYs) on advocating for social justice within PETE programs. A phenomenological approach with mixed-methods design was used. Findings emphasise the importance of fairness, …

Debt Decisions: The Effects Of Paying For College In The United States With Student Loans, Kim E. Bullington, David J. Thomas, Minghui Hou, William L. Nuckols, Dennis E. Gregory, Joshua L. Howell, Kaycee L. Bills, Amy-Leah Joaquim

Educational Leadership & Workforce Development Faculty Publications

Student loans have increasingly become a burden on individuals. This qualitative analysis explores how structural inequities and financial literacy gaps influence U.S. student loan borrowers’ decisions to finance postsecondary education. The study highlights racial and economic disparities examining participants’ reflections on debt aversion and systemic barriers to equitable access. We asked why participants took out Federal student loans, asked about their decision processes when taking on debt, whether participants took any action to reduce accumulated debt, and if they’d made any discoveries about their decisions to take on student loan debt. After coding and a thematic analysis, five themes and …

Identifying Notch-Regulated Genes Using A Specific Notch Signaling Inhibitor, Hammed Gafar

EWU Masters Thesis Collection

Bone remodeling is a dynamic process that requires a balance between bone resorption by osteoclasts and bone formation by osteoblasts to maintain skeletal integrity. Disruptions to this equilibrium can lead to pathological conditions such as osteoporosis. Osteoclasts originate from macrophages, and their differentiation is regulated by several signaling pathways, notably the notch signaling pathway. Gamma-secretase, an enzyme crucial for initiating notch signaling, can be inhibited by DAPT. However, DAPT also targets non-Notch substrates, complicating the identification of genes specifically regulated by Notch. To address this limitation, this study employed IMR-1A, a selective Notch pathway inhibitor that disrupts the assembly of …

Addressing Cte Faculty Shortages In Community Colleges: Perspectives From The Field, Brandon Hensley, Michelle E. Bartlett, James E. Bartlett Ii, Sophia Alston

Educational Leadership & Workforce Development Faculty Publications

This study investigates the motivations, challenges, and institutional strategies shaping the recruitment and retention of postsecondary Career and Technical Education (CTE) faculty in North Carolina. Drawing on quantitative data from 171 North Carolina participants in a national survey, the research provides a localized perspective on faculty workplace experiences within the state’s community college system. Grounded in Herzberg’s Two-Factor Theory and Job Embeddedness Theory, the analysis identifies key factors influencing job satisfaction, faculty stability, and the perceived effects of ongoing instructor shortages. The study’s findings are organized around four central research questions and present a comprehensive analysis of the challenges associated …

Bridging Prairie Restoration And Regenerative Agriculture With Compost Tea / The Rocket Incident: Post-Fire Soil Microbe Recovery On The Eastern Washington University Restoration Site, April Hersey

EWU Masters Thesis Collection

Inland Pacific Northwest prairie is an endangered ecosystem that has been reduced by conversion to agriculture. There is growing interest in the role of soil microorganisms in prairie ecosystems, which may be crucial for restoration of the plant community through interspecies interactions within the rhizosphere. One method for improving soil microorganism community composition is compost tea: enriched liquid compost extract. Compost tea is used in regenerative agriculture to improve crop yields and protect against pathogens. While research has supported compost tea application in regenerative agriculture, it has not been widely studied in the context of ecosystem restoration. After beginning a …

Self-Efficacy And Stem Education: A Study Of Family And Consumer Science Teachers In Pennsylvania, Charlene Smith, Philip A. Reed

Educational Leadership & Workforce Development Faculty Publications

Science, technology, engineering, and mathematics (STEM) education has become widely promoted. Family and Consumer Sciences (FCS) uses science to improve home life while reinforcing technology, engineering, and mathematics principles. However, FCS is not usually recognized as a STEM subject. The purpose of this study was to determine what factors may affect FCS teachers’ level of self-efficacy in teaching STEM to provide supports that improve teaching practices. This quantitative study surveyed secondary FCS teachers in Pennsylvania using the T‐STEM Survey for Elementary Teachers. Results were analyzed using descriptive statistics and simple linear regression analysis was performed to determine the predictive …

Employers' Perceived Value Of High School Industry Recognized Credentials, Teri Harris, Mickey Kosloski, Philip A. Reed

Educational Leadership & Workforce Development Faculty Publications

The purpose of this study was to determine whether industry-recognized credentials (IRCs) earned in secondary school led to quality employment and which IRCs should be integrated into career and technical education (CTE) high school courses. Using survey data from business leaders across the 14 nationally recognized Career Clusters (Advance CTE, 2024a), credentials were ranked by importance within five program areas (n = 257). Pareto analysis revealed 80% of respondents rated health sciences, family and consumer sciences, and agricultural sciences credentials highest, while business/marketing and skilled/technical sciences/STEM credentials did not rank in the top 20%. This research provides empirical evidence for …

Food Insecurity And Academic Self-Efficacy: Military Students And Student Veterans, Kim E. Bullington, Matthew J. Smith, William L. Nuckols, Dennis E. Gregory, Joshua L. Howell

Educational Leadership & Workforce Development Faculty Publications

Food insecurity (FI) affects households worldwide and is also seen on college and university campuses with adverse effects on student success. We examine FI and academic self-efficacy levels of military students and student veterans enrolled in higher education in the United States which has not been extensively studied regarding FI. Military students and student veterans may have access to G.I. Bill funds and may not be perceived as requiring additional assistance. The results reveal that military students and student veterans have some level of FI. The qualitative analysis yielded five themes that center on FI, economic vulnerability, inequities in the …

Osteoclastogenic Potential Of Cd68-Expressing Osteoclast Precursor Cells, Colton Quinn

EWU Masters Thesis Collection

Bone remodeling is a dynamic process maintained by the balance between osteoblast-mediated bone formation and osteoclast-driven resorption. When this balance is disrupted, pathological bone loss occurs, as seen in osteoporosis, rheumatoid arthritis, and cancer-induced bone disease (Teitelbaum, 2007; Korol & Baumeister, 2023; Ensrud & Crandall, 2017). Osteoclasts, derived from hematopoietic stem cells through a macrophage lineage, play a central role in bone resorption. However, the identity of all proteins of osteoclast precursors remains unclear. CD68, a lysosomal glycoprotein widely expressed in macrophages and monocyte-lineage cells (Holness & Simmons, 1993), has been proposed as a marker of osteoclast precursors. Some studies …

Cannabinoid-2 Receptor Activation Attenuates Sulfur Mustard Analog 2-Chloroethyl-Ethyl-Sulfide-Induced Acute Lung Injury In Mice, Gregory Nicholson, Nicholas Richards, Janette Lockett, My Boi Ly, Raj V. Nair, Woong-Ki Kim, K. Yaragudri Vinod, Nagaraja Nagre

Department of Biomedical and Translational Sciences Faculty Publications

Background: Exposure to sulfur mustard (SM; 2,2′-dichlorodiethyl sulfide) causes toxicity in the human body, particularly the lungs. The molecular mechanisms of SM-induced lung damage are elusive, and no effective treatments exist. This study explores the anti-inflammatory potential of cannabinoid receptor 2 (CB2R) activation in mitigating acute lung injury (ALI) and inflammation induced by 2-chloroethyl ethyl sulfide (CEES), a structural analog of SM. Methods: C57BL/6J mice were exposed to CEES via intratracheal administration to model ALI. CB2R activation was achieved through the intraperitoneal administration of HU308, a selective synthetic agonist. ALI and inflammation were evaluated at 48 h post-exposure to CEES. …

Interaction Of Cardiac Leiomodin With The Native Cardiac Thin Filament, Madison Little, Cristina M. Risi, Tania M. Larrinaga, Mason D. Summers, Tyler Nguyen, Garry E. Smith Jr., Jennifer Atherton, Carol C. Gregorio, Alla S. Kostyukova, Vitold E. Galkin

Department of Biomedical and Translational Sciences Faculty Publications

Every heartbeat depends on cyclical contraction-relaxation produced by the interactions between myosin-containing thick and actin-based thin filaments (TFs) arranged into a crystalline-like lattice in the cardiac sarcomere. Therefore, the maintenance of thin filament length is crucial for myocardium function. The thin filament is comprised of an actin backbone, the regulatory troponin complex and tropomyosin that controls interactions between thick and thin filaments. Thin filament length is controlled by the tropomodulin family of proteins; tropomodulin caps pointed ends of thin filaments, and leiomodin (Lmod) promotes elongation of thin filaments by a “leaky-cap” mechanism. The broader distribution of Lmod on the thin …

Clinical Pharmacology And Medication Safety: A Remote Learning Elective Designed For Senior Medical Students, Elizabeth B. Graham, William T. Wightkin, Curt R. Bay, Uzoma S. Ikonne

Department of Biomedical and Translational Sciences Faculty Publications

In the United States, medical educators have expressed concern that an integrated and condensed pre-clerkship curriculum risks leaving gaps in student pharmacology knowledge. This study evaluates a remote-learning clinical pharmacology elective that integrates fundamental pharmacology concepts and principles of medication safety and explores how the course impacts senior medical students' self-reported readiness for residency. Clinical Pharmacology and Medication Safety is a remote elective course for senior medical students. The course integrates a review of basic pharmacology with clinical pharmacology topics through case-based learning sessions led by clinical pharmacists and physicians. To evaluate the elective's effectiveness, students in the fall and …

The Central Role For Troponin C Amino-Terminal ⍺-Helix In Vertebrate Thin Filiment Ca²⁺-Activation, Yun Shi, Lauren A. Blackwell, Ryan K. Schroy, B. Max Cleland, Cristina M. Risi, Michelle S. Parvatiyar, Jose R. Pinto, Vitold E. Galkin, P. Bryant Chase

Department of Biomedical and Translational Sciences Faculty Publications

Troponin C (TnC) is the Ca²⁺-sensing subunit of troponin that is responsible for activating thin filaments in striated muscle, and, in turn, for regulating the systolic and diastolic contractile function of cardiac muscle. The secondary structure of vertebrate TnC is mainly composed of α-helices, with nine helices named sequentially, starting from the amino terminus, from N to A–H. The N-helix is a 12-residue-long α-helix located at the extreme amino terminus of the protein and is the only helical structure that does not participate in forming Ca²⁺-binding EF-hands. Evolutionarily, the N-helix is found only in TnC from mammalian species and most …

Protein Marker-Dependent Drug Discovery Targeting Breast Cancer Stem Cells, Ashley V. Huang, Yali Kong, Kan Wang, Milton L. Brown, David Mu

Department of Biomedical and Translational Sciences Faculty Publications

Breast cancer is one of the most common cancers globally. Unfortunately, many patients with breast cancer develop resistance to chemotherapy and tumor recurrence, which is primarily driven by breast cancer stem cells (BCSCs). BCSCs behave like stem cells and can self-renew and differentiate into mature tumor cells, enabling the cancer to regrow and metastasize. Key markers like CD44 and aldehyde dehydrogenase-1 (ALDH1), along with pathways like Wingless-related integration site (Wnt), Notch, and Hedgehog, are critical to regulating this stem-like behavior of BCSCs and, thus, are being investigated as targets for various new therapies. This review summarizes marker-dependent strategies for targeting …

Eeg Spectral Analysis Of Nighttime Sleep And Daytime Mslts And Neurocognitive Evaluations In Subjects With Co-Morbid Insomnia And Osa, Yuan Shi, Yuru Nie, Fengyi Hao, Xujun Feng, Ye Zhang, Larry D. Sanford, Rong Ren, Xiangdong Tang

Department of Biomedical and Translational Sciences Faculty Publications

Background

Chronic insomnia and obstructive sleep apnea commonly co-occur. Few studies have explored the neurophysiological and neurocognitive characteristics of COMISA, which could help guide improving treatment diagnostic tools and determining novel therapeutic targets. This study aims to explore the neurophysiological and neurocognitive characteristics of COMISA using electroencephalographic (EEG) spectral analysis and subjective and objective neurocognitive measurements.

Methods

Participants were from our community recruited OSA-insomnia-COMISA cohort with 206 included for our current analysis including 74 chronic insomniacs (CIs), 55 OSA patients and 77 COMISA patients. Standard polysomnography (PSG) and multiple sleep latency tests (MSLTs) were recorded and used to obtain relative …

Codon Composition In Human Oocyters Reveals Age-Associated Defects In Mrna Decay, Pavla Brachova, Lane K. Christenson, Nehemiah S. Alvarez

Department of Biomedical and Translational Sciences Faculty Publications

Oocytes from women of advanced reproductive age exhibit diminished developmental potential, but the underlying mechanisms remain incompletely defined. Oocyte maturation depends on translational control of maternal mRNA synthesized during growth. We performed a computational analysis on human oocytes from women < 30 versus ≥40 years and observed that mRNA GC content correlates negatively with half-life in oocytes from young (< 30 yr) but positively with oocytes from aged (>40 yr) women. In young oocytes, longer mRNA half-life is associated with lower protein abundance, whereas in aged oocytes GC content correlates positively with protein abundance. During the GV-to-MII transition, codon composition stratifies stability: codons that support rapid translation (optimal) stabilize mRNA, while slow-translating codons (non-optimal) promote decay. With reproductive aging, GC-containing codons become more optimal and align with increased …

Antibiotic Resistance: The Growing Threats And Potential Solutions, Olisaemeka Zikora Akunne, Blessing Nkechi Emmanuel, Umar Faruk Saidu, Ayobami Sunday Akinnawo, Nasiru Ademola Adeyemi, Livia Chinaza Egoh, Malami Aishatu Muhammad, Olusegun Ayo Ade-Adekunle, Deborah Ahuoyiza Peter, Anne Amina Freitas

Department of Biomedical and Translational Sciences Faculty Publications

Antibiotic resistance (AR) has become a critical global health crisis, threatening the efficacy of antibiotics and increasing healthcare costs, morbidity, and mortality. The One Health approach, which emphasizes the interconnectedness of human, animal, and environmental health, is increasingly recognized as an essential framework for addressing the complex drivers of AR. This review explores the mechanisms of resistance, such as genetic mutations, horizontal gene transfer, and biofilm formation, along with contributing factors such as the overuse of antibiotics in healthcare and agriculture. We assess both traditional and emerging strategies to combat AR, including antimicrobial stewardship, the development of new antibiotics, and …

Deletion Of Chop In Beta Cell Protects Mice From Cardiovascular Complications In Type 2 Diabetes: Evidence From A Pre-Clinical Mouse Model, Balaji Srinivas, Kiran Alluri, Nour-Eddine Rhaleb, Khalid Matrougui

Department of Biomedical and Translational Sciences Faculty Publications

Introduction

Cardiovascular complications are the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D), which is recognized as a major independent risk factor for coronary artery disease, stroke, peripheral vascular disease, and heart failure. The interrelationship between metabolic dysfunction and cardiovascular disease is complex and multifactorial, involving hyperglycemia, insulin resistance, inflammation, and oxidative stress. Evidence indicates that endoplasmic reticulum (ER) stress and induction of the unfolded protein response (UPR) contribute to metabolic dysregulation and vascular dysfunction. However, the specific role of beta cell-derived UPR mediators, particularly C/EBP homologous protein (CHOP), in coordinating this interorgan axis between …

Swinging Lever Mechanism Of Myosin Directly Shown By Time-Resolved Cryo-Em, David P. Klebl, Sean N. Mcmillan, Cristina Risi, Eva Forgacs, Betty Virok, Jennifer L. Atherton, Sarah A. Harris, Michele Stofella, Donald A. Winkelmann, Frank Sobott, Vitold E. Galkin, Peter J. Knight, Stephen P. Muench, Charlotte A. Scarfi, Howard D. White

Department of Biomedical and Translational Sciences Faculty Publications

Myosins produce force and movement in cells through interactions with F-actin¹. Generation of movement is thought to arise through actin-catalysed conversion of myosin from an ATP-generated primed (pre-powerstroke) state to a post-powerstroke state, accompanied by myosin lever swing²,³. However, the initial, primed actomyosin state has never been observed, and the mechanism by which actin catalyses myosin ATPase activity is unclear. Here, to address these issues, we performed time-resolved cryogenic electron microscopy (cryo-EM)⁴ of a myosin-5 mutant having slow hydrolysis product release⁵,⁶. Primed actomyosin was predominantly captured 10 ms after …

Phenotype Specific Nuclear Lamina Remodeling In Hipsc Derived Cardiomyocytes Bearing Tnnt2 Sarcomeric Variants, Isabella Leite Coscarella, Olalekan H. Usman, Lili Wang, Maicon Landim-Vieira, Lillian Wirstiuk, Amber N. Brown, Diego A. R. Zorio, Brian K. Washburn, Cynthia Vied, Bjorn C. Knollmann, Christopher Solís, Vitold E. Galkin, P. Bryant Chase, J. Travis Hinson, Jerome Irianto, Jose Renato Pinto

Department of Biomedical and Translational Sciences Faculty Publications

[Summary] Cardiomyocytes endure physical stress from the myocardium environment while generating their own mechanical strains. The force generated by sarcomeres is transmitted both longitudinally to adjacent sarcomeres and laterally to the cytoskeleton via intermediate filaments. This mechanical stimulus impacts other organelles, including the nucleus, thus playing a vital role in sensing and signaling nuclear adaptations. However, there is limited understanding of how changes in cardiac contractility affect nuclear mechanics. Here, we sought to investigate the effects of hyper- and hypo-contractility in nuclei of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) bearing TNNT2 pathogenic variants associated with hypertrophic (HCM) or dilated …

Women Leaders' Lived Experiences Of Bravery In Leadership, Michelle E. Bartlett

Educational Leadership & Workforce Development Faculty Publications

Purpose

The research aims to understand the stories of women leaders who have demonstrated bravery in leadership. By analyzing their lived experiences through storytelling and narratives, it seeks to shed light on the challenges and motivations behind their brave actions, contributing to a deeper understanding of bravery in leadership within gender and organizational contexts.

Design/methodology/approach

This study adopts a qualitative multiple case study approach, focusing on the autobiographical accounts of three women leaders to explore their experiences of bravery in leadership. Utilizing narrative analysis (NA), it is grounded in ethical leadership theory and narrative identity theory. The research method involves …

Coastal Empire Economic Monitor, 1st Quarter, 2025, Georgia Southern University Center For Business Analytics And Economic Research

Coastal Empire Economic Monitor

• Forward Momentum Weakening

• Savannah Metro Economy Growth Slows

• U.S. Economy Shrinks, 2025 Outlook Remains Murky

• Forecasting Index Falls

If You Charge Them, Will They Come? The Effect Of Levying Tuition Fees In International Students, Charles Mathies, Hannu Karhunen, Stephen L. Desjardins

Educational Leadership & Workforce Development Faculty Publications

In 2017, Finland began levying tuition fees on non-European Union (EU)/European Economic Area (EEA) international students. Using data from multiple Finnish government sources, we study the impact of tuition fee reform at various stages of the higher education enrollment selection process. Outcomes examined include how the policy change affects student application behavior, admissions and acceptances by institutions, and student enrollments. To identify the effects of the policy change, we employ a difference-in-differences approach using national register data and program-level tuition variations. Our findings led to three key findings: (1) the implementation of fees did not decrease the number of applications …

Towards Dynamic Learner State: Orchestrating Ai Agents And Workplace Performance Via The Model Context Protocol, Mohan Yang, Nolan Lovett, Belle Li, Zhen Hou

Educational Leadership & Workforce Development Faculty Publications

Current learning and development approaches often struggle to capture dynamic individual capabilities, particularly the skills they acquire informally every day on the job. This dynamic creates a significant gap between what traditional models think people know and their actual performance, leading to an incomplete and often outdated understanding of how ready the workforce truly is, which can hinder organizational adaptability in rapidly evolving environments. This paper proposes a novel dynamic learner-state ecosystem—an AI-driven solution designed to bridge this gap. Our approach leverages specialized AI agents, orchestrated via the Model Context Protocol (MCP), to continuously track and evolve an individual’s multi-dimensional …

[Review Of The Book Expanding Approaches To Thematic Analysis: Creative Engagements With Qualitative Data By J. R. Wolgemuth, K. W. Guyotte, & S. A. Shelton (Eds.)], Nazmun Nahar Chaitee

Educational Leadership & Workforce Development Faculty Publications

In Expanding Approaches to Thematic Analysis, editors Jennifer R. Wolgemuth, Kelly W. Guyotte, and Stephanie Anne Shelton introduce an expansive, paradigm-shifting book that reimagines thematic analysis beyond conventional coding methods. This edited volume begins with two presumptions: (1) there are multiple methods of theming data, and (2) qualitative researchers are not necessarily required to code to achieve themes. Through the convergence of various qualitative researchers and early-career scholars, this edited collection pushes thematic analysis into new epistemological territories. The 18 chapters of the book reveal new techniques, such as meditative theming, poetic analysis, and making art, underpinned by theoretical …

Quiet Resistance: Drawing On Covert Advocacy Research To Understand School Leadership Within The Current Anti-Trans Context, Alexandria Gribble, Erica Simpson, Meagan S. Richard

Educational Leadership & Workforce Development Faculty Publications

Over the last few years, there has been a surge in anti-LGBTQIA+ and, specifically, anti-transgender, nonbinary, and gender non-conforming legislation. These laws target the rights of LGBTQIA+ students in K–12 schools, leading to policies censoring gender-inclusive curricula, mandating the outing of students, and restricting transgender students’ access to sports and facilities. The rapid emergence of these bills has outpaced research on how leaders—particularly justice-centred leaders—navigate these hostile policy contexts. Existing research taking a broader lens around leaders’ justice work in schools sheds light on how leaders engage in covert advocacy within complex and constraining contexts. However, understanding how leaders resist …

Why Some Companies Weather Trade Was Better Than Others?, Di Fan, Daphne W. Yiu, Pengcheng Ma, Lin Cui

Research Collection Lee Kong Chian School Of Business

In 2018, the U.S. government levied tariffs affecting more than $250 billion of Chinese products. As a result, many American buyers began turning to alternative suppliers to avoid the significant new costs associated with purchasing from China. Recent research found that transactions between U.S. buyers and Chinese suppliers fell by more than 18% immediately following the start of the trade war. However, the study also found that not all companies were affected equally: Chinese firms that were more innovative or more socially responsible were more likely to retain their U.S. buyers, while buyers were more likely to distance themselves from …

Annual Report 2024-2025, Office Of Sponsored Programs

Annual Reports

No abstract provided.

Demographic Profiles Of San Diego And Imperial Counties, Tessa Tinkler, Eo Hanabusa, Laura Deitrick, Connelly Meschen

Nonprofit Sector Issues and Trends

The Demographic Profiles of San Diego and Imperial Counties provides a snapshot of the two counties' vulnerable populations, including low-income communities, youth, immigrants, refugees, individuals experiencing homelessness, and retirement-age adults. While these counties differ in population size by more than an order of magnitude, the backdrop of California's rising cost of living, shifting immigration policies, income and health disparities, and the projections for an increasing aging population present compounding barriers to financial stability and access to services for all ages. Comprehensive data to understand these community needs was more readily available for San Diego County than Imperial County. This report …