Digital Commons Network^™

Normative Laboratory Value Ranges In Pediatric Patients Who Underwent Evaluation For Mis-C, Thomas Graf, Nathan M Money, Sindhoosha Malay, Nori Minich, Risa Bochner, Bari Winik, Ron Kaplan, Jennifer Y Colgan, Erin Aldag, Ryan O' Sullivan, Guliz Erdem, Allayne Stephans

Faculty, Staff and Student Publications

Background and objectives: Diagnosis of multisystem inflammatory syndrome in children (MIS-C) is challenging due to symptom overlap with other common conditions. The primary objective of this multicenter study was to establish normative laboratory values in MIS-C patients and compare to patients evaluated for MIS-C who had other final diagnoses.

Methods: Five hospitals reviewed records of a cohort of patients 6 months to 18 years old who were evaluated for MIS-C between March 31st 2020 and February 1st 2022. Patient demographics, clinical presentation, and laboratory values were compared in patients with a final diagnosis of MIS-C versus all other conditions. Patients' …

Three-Dimensional Deep Learning Normal Tissue Complication Probability Model To Predict Late Xerostomia In Patients With Head And Neck Cancer, Hung Chu, Suzanne P M De Vette, Hendrike Neh, Nanna M Sijtsema, Roel J H M Steenbakkers, Amy Moreno, Johannes A Langendijk, Peter M A Van Ooijen, Clifton D Fuller, Lisanne V Van Dijk

Faculty, Staff and Student Publications

Purpose: Conventional normal tissue complication probability (NTCP) models for patients with head and neck cancer are typically based on single-value variables, which, for radiation-induced xerostomia, are baseline xerostomia and mean salivary gland doses. This study aimed to improve the prediction of late xerostomia by using 3-dimensional information from radiation dose distributions, computed tomography imaging, organ-at-risk segmentations, and clinical variables with deep learning (DL).

Methods and materials: An international cohort of 1208 patients with head and neck cancer from 2 institutes was used to train and twice validate DL models (deep convolutional neural network, EfficientNet-v2, and ResNet) with 3-dimensional dose distribution, …

Bronchoalveolar Lavage Cell Percentages As Diagnostic Markers Of Immune Checkpoint Inhibitor Pneumonitis, Mahnoor Mir, Felipe Soto, Pedro Antonio Amezcua Gomez, Rodrigo Del Rio Arroyo, Adarsh Suresh, Amber Su, Qiong Gan, John Stewart, Roberto Adachi, Diwakar D Balachandran, Lara Bashoura, Roberto F Casal, Burton F Dickey, George A Eapen, Scott E Evans, Horiana Grosu, Carlos A Jimenez, Julie Lin, David E Ost, Bruce F Sabath, Vickie R Shannon, Aung Naing, Jianjun Gao, Jia Wu, Karthik Suresh, Saadia A Faiz, Mehmet Altan, Ajay Sheshadri

Faculty, Staff and Student Publications

Introduction: Diagnostic biomarkers for immune checkpoint inhibitor pneumonitis (ICIP) are lacking. Bronchoalveolar lavage (BAL) lymphocytosis has been associated with ICIP, but studies have not evaluated BAL lymphocytosis as a diagnostic biomarker for ICIP.

Purpose: This study aimed to measure the association of BAL immune cell percentage with ICIP and test its performance as a diagnostic biomarker.

Methods: We performed a retrospective chart review of 476 patients treated with ICIs for solid organ or hematologic malignancies who underwent BAL between 2016 and 2022. Two independent reviewers, blinded to the results of BAL cell percentage, confirmed the diagnosis of ICIP or other …

Deep Dive Into Targeted Therapies: Understanding Idh1-Mutant Aml Treatments [Podcast], Amer M Zeidan, Courtney Dinardo

Faculty, Staff and Student Publications

This podcast episode reviews recent advances in the treatment of IDH1-mutant acute myeloid leukemia (AML), focusing on the mechanisms, efficacy, and safety profiles of approved IDH1 inhibitors. The purpose is to present expert insights and clinical data from key trials that underscore the clinical benefits of these targeted therapies. Through discussion of key findings from pivotal clinical trial studies, including data supporting the use of these agents in both newly diagnosed and relapsed or refractory (R/R) settings, the episode highlights significant outcomes such as increased overall response and prolonged duration of remission in patients treated with IDH1 inhibitors. The analysis …

Wait... Homework Can Be Fun?! A Pilot Homework System Study, Caroline Brock

Cal Poly Humboldt theses and projects

Homework has been a long-debated topic in schools. Regardless of where people stand on the issue, the evidence shows that quality homework can be an effective tool to help students be successful in school. Beyond academics, homework can also be used as a tool to help students develop important foundational study skills that are critical for future success. But how can school districts get all stakeholders behind a homework system if they do not see the value of homework, or if the homework is a point of individual or familial stress. Through an action research project using mixed methods, parents …

Curriculum Addressing Recidivism: A Case Study Of Project Rebound’S Youth Empowerment Program, Julie Stewart

Cal Poly Humboldt theses and projects

Providing effective rehabilitation for justice-involved youth is an increasing priority within the American social justice system, yet remains a significant challenge. The Youth Empowerment Program (YEP) at Cal Poly Humboldt uses curriculum to support learning objectives related to emotional intelligence, critical thinking, and emotional maturation, with the broader goal of reducing recidivism among youth in Northern California. Although curriculum design is widely understood in education as essential for effective learning, limited research examines how youth rehabilitation programs in carceral settings use curriculum to address the developmental and learning needs of participants. Using a case study methodology, this research examines how …

Kelp Guardians Can Save The World: A Food Sovereignty Lab Report Of The Ghvtlh-K’Vsh Shu'-Srnelh-'I~ (Kelp Guardians) California Sea Grant, Delaney A. Schroeder-Echavarria

Cal Poly Humboldt theses and projects

As partners of the Ghvtlh-k’vsh Shu'-srnelh-'i~ (Kelp Guardians) California Sea Grant project, the Rou Dalagurr Food Sovereignty Lab and Traditional Ecological Knowledges Institute has actively engaged with local educators, Tribal organizations, and Tribal Nations to create youth-centered curricula, researched through a community-based participatory research lens. This is demonstrated through an innovative approach to recruiting and retaining Indigenous youth and community interest in coastal and marine ecosystems and resources by connecting with Indigenous cultural practices, Indigenous sciences, and community-based programs to encourage future careers. The Kelp Guardians project is led by the Tolowa Dee-ni’ Nation (TDN or Nation) and includes various …

Student Housing Insecurity And Its Impacts On Academic Enthusiasm: A Multi-Method Analysis Of Cal Poly Humboldt, Aaron Gabriel Perez

Cal Poly Humboldt theses and projects

Cal Poly Humboldt has faced major challenges in the realm of housing due to a long history of shortages and difficulties in prioritizing the distribution of housing amongst the student population. Recent issues such as the mold infestations in Fall 2024 bring this into focus as the campus is also trying to expand its available housing through constructing new housing facilities. This in conjunction with the campus’ desire to continually increase its student population base year by year brings into question the fundamental goals of the campus and whether or not students feel the campus is helping or hurting them. …

Assessment Of The Genetic Population Structure And Extent Of Clonality In A Rare Serpentine Endemic, Lathyrus Biflorus T.W. Nelson & J.P. Nelson (Fabaceae), Using Ddrad Sequencing, Ashley Dickinson

Cal Poly Humboldt theses and projects

Lathyrus biflorus, or the two-flowered pea, is a rare herbaceous perennial restricted to a single population in Northern California. The species is considered critically imperiled but remains unprotected under state or federal endangered species acts. Despite its rarity, little is known about its life history, reproductive biology, or genetic diversity. Using genome-wide reduced representation sequencing, this study aimed to address these gaps by investigating the molecular evidence of clonality, the number and diversity of genets (unique genetic individuals which can be made up of one or many clonal units or ramets), and overall genetic health of the population. My …

Who Are We Restoring Maunalua For? Place Name Resurgence And Environmental Restoration In Maunalua, O‘Ahu, Cassidy J. Hollenbeck

Cal Poly Humboldt theses and projects

While numerous research studies have been published in recent decades on biological degradation and climate risks facing Maunalua, very few studies have centered on the sociopolitical dimensions of this region. By celebrating community pilina (intimacy, relationship) and biocultural restoration in Maunalua, this project aims to challenge the dominant narratives of degradation on this region. Centering Decolonizing and Kanaka ‘Ōiwi methodologies, this project builds on N. Ha‘alilo Solomon’s book chapter, Maunalua: Shifting Nomenclatures and the Reconfiguration of Space in Hawaii Kai (2022), celebrating ongoing projects of inoa ‘āina (place name) resurgence. Engaging snowball sampling in qualitative community-based participatory research methods, I …

The Impact Of Plant-Based Diets On Erythrocyte Function, Oxidative Stress, And Vascular Inflammation In Type 2 Diabetes Mellitus, Walter G. Craig

Cal Poly Humboldt theses and projects

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder with diverse etiological contributors, characterized by insulin resistance, chronic inflammation, oxidative stress, and an increased risk of vascular complications. While much research has focused on plasma and serum markers of metabolic dysfunction, the role of erythrocytes in diabetic pathophysiology remains underexplored. This review examines the impact of dietary macronutrient composition, particularly plant-based diets, on erythrocyte function, oxidative stress, and vascular inflammation in T2DM. Red blood cells (RBCs) are not only oxygen carriers but also dynamic regulators of immune and inflammatory responses, with structural and functional alterations playing a critical role …

An Assessment Of The California Logging Workforce, Kendra Jean Gerstenberg

Cal Poly Humboldt theses and projects

There is limited literature describing the capacity and capabilities of the logging workforce in California. This study examines the logging workforce in California to quantify the number of logging crews, assess demographic diversity, and evaluate capacity and capabilities. The target population was California Licensed Timber Operators (LTOs) who have the legal right to harvest timber. A survey was developed and distributed to LTOs on the CAL FIRE database. Surveys were also distributed at regional logging conferences or collected by phone. Data were analyzed using Statistical Package for the Social Sciences (SPSS) and emergent coding for follow-up interviews was conducted. There …

"Gen Z Climate Being": Podcast Series On Youth, Climate Emotions, And Affective Climate Justice, Rachel Wynne Moszkowicz

Cal Poly Humboldt theses and projects

My project is a co-created 6 part podcast series with youth and the program lead from the Climate Mental Health Network’s Gen Z Advisory Board informed by affective climate justice, youth, mental health and education. This work foregrounds the embodied climate knowing and being of youth climate activists, offers ideas for a different relationship to climate change and climate education futures. In this podcast, Gen Zers speak to the youth mental health crisis as it relates to climate. My thesis project engages with and invites conversations that reflect the climate itself, which is non-linear, complex, porous, creative, expansive, and woven …

An Evaluation Of Fuel Model Accuracy And Multi-Scale Mitigation Strategies In The Wildland-Urban Interface Of Southern Humboldt County, Julia I. Cavalli

Cal Poly Humboldt theses and projects

Strategic placement of fuel treatments is critical for mitigating wildfire risk and reducing potential structure losses in wildland-urban interface (WUI) communities. As wildfire activity accelerates across the western United States, the need to identify high-impact fuel treatment locations grows increasingly urgent. Concurrently, housing development in the WUI is expanding, intensifying the exposure of homes and infrastructure to wildfire threats. In response, many communities are looking to mitigate the likelihood and severity of losses during wildfire events. The success of these efforts depends, in part, on robust data to support strategic placement of effective treatments that reduce fuel availability.

This study …

Groundwater Pumping Impacts On Stream Depletion In Humboldt County, Ca: Integrating Analytical Models And Field Data, Andy Hans Heise

Cal Poly Humboldt theses and projects

This study addresses the significant concern of stream depletion from groundwater pumping in Humboldt County, CA. The objective of this study is to develop an analytical model for estimating stream depletion and integrating field data into model parameters.

The methodology involved conducting a field study near three operating wells by a stream, installing stream gages upstream and downstream of the wells, and recording pumping rates and schedules for two of the wells. The third well’s pumping data was synthetically generated, for privacy concerns of the well owner. The StreamDepletR package was used for estimating depletion rates in a stream in …

Twice-Exceptionalism And The Complexity Of Supporting Students Who Are Both Gifted And Disabled, River Johnathon Taylor

Cal Poly Humboldt theses and projects

Drawing on ideas from disabilities studies about compulsory able-bodiedness as well as experiences of disability being fluid and context dependent, this study posits that giftedness, just like disability, is a complex multidimensional form of identity that is both context and temporally dependent. Twice-exceptionalism is defined as an identity in which an individual is gifted in at least one domain of human productivity and manifests at least one disability. Students with unique learning needs (students with disabilities, students with giftedness, and students with twice-exceptionalism) face many complex challenges within Humboldt County, California. Twenty-five educators from Humboldt County working across all grade …

Patterns Of Tree Damage And Fuels Around Powerlines In Northern California, Zoe J. Ziegler

Cal Poly Humboldt theses and projects

Rural powerlines are critical for delivering electricity to communities far from urban areas but present a significant hazard when located in forested regions. During strong wind events, tree failure (i.e., broken branches, snapped stems, and windthrow) can bring combustible material in contact with high-voltage lines, causing electrical outages or setting fire to vegetation below the powerline. Additionally, elevated forest fuel loading can increase wildfire rate of spread and intensity, potentially increasing negative ecosystem impacts and decreasing containment capacity during powerline- ignited wildfires. The risks associated with rural electrical infrastructure, tree failure, and elevated fuel loading emphasize the need for improved …

Home Range, Habitat Use, And Fall Migration Of Lewis’S Woodpeckers In The Eastern Cascade Range, Oregon, Cameron Piper

Cal Poly Humboldt theses and projects

Lewis’s woodpecker (Melanerpes lewis), a burn specialist, is experiencing range-wide population declines despite increasing fire activity in the western U.S. The White River Wildlife Area in Oregon hosts the state's only year-round population, raising questions about their breeding, habitat use, and migration. In summer 2024, we tracked nine woodpeckers using telemetry to estimate home range size and overlap. Full home ranges averaged 428 ha, with 66 ha core areas, and showed evidence of growing after nesting. Home ranges overlapped extensively (Full: 91 ± 13%; Core: 63 ± 29%), though individuals had distinct areas of intense use. Males had …

Can We Help Coast Redwood Adapt To Climate Change? A Provenance Study On Genetic Variation And Climate Transfer Distance, Aidan J. Murphy

Cal Poly Humboldt theses and projects

The climate is changing more rapidly than many species can adapt or migrate. Coast redwood (Sequoia sempervirens) is a unique, long-lived conifer and remains California’s most valuable and economically important timber species. The species is threatened in its natural range due to anthropogenic climate change and human activity. Redwood favors asexual reproduction which restricts its ability to migrate naturally. The consequences of asexual reproduction when faced with a rapidly changing climate may make some form of assisted migration necessary for long-lived organisms like redwood.

This study evaluates drivers of variation in redwood growth and the influence of climate …

The Menstrual Cycle, Dual-Hormone Hypothesis, And Competition: Implications For Athletic Performance, Camille Burns

Cal Poly Humboldt theses and projects

Female athletes perceive that the fluctuating hormones of the menstrual cycle affect their performance. However, research on objective performance is inconclusive, partly due to a lack of studies conducted in real-world competitive contexts. Testosterone is often seen to be elevated near ovulation and is related to social competitiveness. Under the dual-hormone hypothesis, testosterone only predicts competitive behavior when cortisol is low. The current study had two goals: (1) to test whether the dual-hormone hypothesis applied to competitive drive and objective athletic performance, and (2) to examine whether competitiveness and the intensity of one’s response to competition varied across the menstrual …

Effects Of Teacher Reinforcements On Student Outcomes In Adapted Physical Education: A Meta-Analysis, Yaxeny Moreno

Cal Poly Humboldt theses and projects

The primary goal is to review the influence of reinforcement strategies in Physical Education (PE) and Adapted Physical Education (APE) settings, focusing on students with disabilities with the ages of 3-22. Reinforcement strategies, such as positive reinforcement/feedback, token economies, verbal praise, tangible rewards, and additional strategies are essential for fostering engagement and skill development. Literature has provided evidence and results to highlight the importance of applying evidence-based reinforcement strategies to which support the behavioral, social, and physical development of students in both Physical Education and Adapted P.E. settings. The purpose of this study was to review and analyze existing literature …

Community Assembly Across Environmental Gradients: Contrasting Patterns Of Funtional Convergence And Divergence In California Coastal Grasslands, Ernesto Chavez- Velasco

Cal Poly Humboldt theses and projects

Elucidating how plant community assembly processes interact across spatial scales to shape ecosystem function remains a central challenge in ecology. These processes are often hierarchical, with broad scale environmental filters constraining the composition of local communities. I investigated these hierarchical processes across three California coastal grassland sites spanning a ~1000 km gradient. At these sites, I measured community composition, standing biomass, four functional traits (plant height, specific leaf area, leaf dry matter content, and leaf lobedness), and estimated species’ environmental niches. To identify assembly mechanisms, I used null models to assess functional convergence or divergence and scaled these patterns with …

Lineation To Liberation: The Transformative Power Of Poetic Rhetoric, Amber Rae Alvarez

Cal Poly Humboldt theses and projects

This project explores the transformative power of poetic rhetoric and examines how poetry as a form of expressive art serves as a means of reclamation in the aftermath of encounters with the American criminal justice system. I contend that poetry provides a space where folks can reimagine (and reclaim) their identities, asserting their agency in empowering and authentic ways. Taking a Cultural Studies and Critical Prison Studies informed approach, this project engages the concept of lineation to liberation to conduct a close reading analysis of artist (Reginald) Dwayne Betts’ poetry. Betts’ work not only provides a powerful example of how …

Impacts Of Autistic Traits On Student Evaluations Of Professors, Matias Solorzano

Cal Poly Humboldt theses and projects

Instructor evaluations are critical to the tenure process in academia, but are biased against autistic individuals in academic settings. This study addresses how instructor evaluations are impacted by the gender of the professor, whether the instructor discloses their autism identity, and the gender of the student evaluator in a 2 Professor Gender (Male or Female) x 2 Autism Identity (Disclosed v. Not Disclosed) x 2 Student Gender (Male or Female) between-subjects design. It was hypothesized that male professors will be rated higher than female professors, that disclosing one’s autism identity leads to higher evaluations than non disclosure, and that female …

An Analysis Of Uv Disinfection Of Municipal Wastewater Following Natural Treatment Systems, Jonathan Andrew Kirchubel

Cal Poly Humboldt theses and projects

On January 30, 2024, the City of Arcata replaced chlorine with ultraviolet (UV) irradiation as its disinfection method for treating its wastewater prior to discharging to Humboldt Bay. The Arcata wastewater treatment facility (AWTF) utilizes natural treatment systems for treating its secondary effluent, which can provide issues for UV disinfection through variance in turbidity, total suspended solids (TSS), pH, humic acids, and color. This project aimed to identify whether the water quality characteristics of natural treatment systems in the AWTF would impact UV disinfection of municipal wastewater.

Thirty-one sampling periods occurred between June 8, 2024, and March 1, 2025, recording …

Effects Of Teacher Reinforcements On Student Outcomes In Adapted Physical Education: A Systematic Review, Juliana Jamison-Espinoza

Cal Poly Humboldt theses and projects

This systematic review examined the effectiveness of various reinforcement strategies on student outcomes in adapted physical education (APE) settings for individuals with disabilities. A comprehensive literature search spanning from 1979 to 2024 across six databases identified 18 studies meeting inclusion criteria, involving 140 participants aged 3–22 with diverse physical and cognitive disabilities. Reinforcement strategies evaluated included token economies, verbal praise, tangible rewards, and alternative techniques such as video modeling and peer-mediated interventions. Outcomes measured were categorized into affective states, behavioral improvements, and cognitive gains. Results showed mixed effectiveness across studies: while 7 of the 18 studies reported significant improvements in …

Evaluating The Effects Of Memory Aids On Conversational Behaviors In Older Adults With Cognitive Decline And Their Caregivers, Sarah B. Romero Pavon

Cal Poly Humboldt theses and projects

As the baby boomer generation (individuals born between 1946 and 1964) continues to age into late adulthood, the need for resources and care related to aging is in high demand. Age-related neurocognitive decline (NCD) is broadly characterized by a gradual decrease in one’s ability to think, remember, and reason. Loss of speech and coherent conversation is a common challenge for older adults with neurocognitive decline, often marked by an increase in nonspecific pronoun use, frequent and sudden shifts in topic, and repetition, which can lead to a decrease in activity engagement, less social interaction with peers, and social isolation. Memory …

General Kernel Machine Methods For Multi-Omics Integration And Genome-Wide Association Testing With Related Individuals, Amarise Little, Ni Zhao, Anna Mikhaylova, Angela Zhang, Wodan Ling, Florian Thibord, Andrew D. Johnson, Laura M. Raffield, Joanne E. Curran, John Blangero

School of Medicine Publications

Integrating multi-omics data may help researchers understand the genetic underpinnings of complex traits and diseases. However, the best ways to integrate multi-omics data and use them to address pressing scientific questions remain a challenge. One important and topical problem is how to assess the aggregate effect of multiple genomic data types (e.g. genotypes and gene expression levels) on a phenotype, particularly while accommodating routine issues, such as having related subjects' data in analyses. In this paper, we extend an existing composite kernel machine regression model to integrate two multi-omics data types, while accommodating for general correlation structures amongst outcomes. Due …

Faith, Freedom, And Friction: The Intersection Of Intimate Citizenship And Religion In Central And Eastern Europe, Evelina Juchnevičiūtė Ms.

Occasional Papers on Religion in Eastern Europe

Intimate citizenship, a dimension of citizenship that emerged from the second wave of feminism, refers to rights related to intimate life, including women’s reproductive rights, same-sex relationships, and other related rights. In Central and Eastern Europe, these rights have been shown to come into conflict with the region’s deeply embedded religious values that have historically shaped societal norms around reproduction, gender, and sexuality. The present study employed a mixed-method systematic literature review, combining bibliometric and thematic analyses, to examine academic literature on the intersection of intimate citizenship and religion in Central and Eastern Europe. The review covered the period 1990-2024 …

Revival Of Tengrism In Kazakhstan As Ancient Belief Of The Kazakh Nation: Prospects And Challenges, Jolaman Bulan, Tussipkhan Imammadi, Aiymzhan Ryskiyeva, Asset Kuranbek

Occasional Papers on Religion in Eastern Europe

This research investigates the resurgence of Tengrism, an ancestral belief system native to Kazakhstan. This traditional religion, rooted in ancient history, encompasses an array of beliefs and rituals that focus on the worship of celestial deity known as Tengri and various forces of nature. It provides a thorough analysis of how public attitudes towards Tengrism and its role within the cultural fabric of the Kazakh people have shifted. The paper also addresses the circumstances that have facilitated Tengrism's revival in the independent nation of Kazakhstan, including issues of national identity, cultural heritage, and spiritual rejuvenation. Furthermore, it explores a range …