Digital Commons Network^™

How Do Young Adults With Drug Use Disorder (Dud) Utilize Treatment? Exploring And Examining Lived Experiences Towards Treatment Completion In Indonesia, Dewi Kartikawatiningsih

Electronic Theses & Dissertations (2024 - present)

In Indonesia which has the highest rate of drug addiction in Southeast Asia, there is currently little knowledge about how young adults perceive the barriers faced when completing treatment or how treatment providers' perspectives influence their treatment completion. Understanding and identifying barriers to treatment completion is essential to making drug treatment more effective. The purpose of this study is to explore the perspectives and live experiences of young adults with DUD and their addiction counselors to develop a deeper understanding of treatment needs. This study interviewed 33 clients and 15 counselors from the rehabilitation center of the Badan Nasional Narkotika …

Essays On Health Economics, Yiran Han

Electronic Theses & Dissertations (2024 - present)

The first chapter examines relationships between physicians exposed to new drugs’ clinical trials and prescribing. Clinical trials benefit patients directly by providing novel treatments, but little is known about the indirect effects of clinical trials on physician prescribing through localized knowledge spillover. This study examines whether exposure to a clinical trial of a new drug in a physician’s local geographic area affects the physician’s propensity to prescribe the drug, i.e. a localized knowledge spillover from clinical trial sites to physician. Utilizing the Medicare Part D prescribing patterns of more than 10,000 physicians across 29 new cancer drugs approved by the …

Theoretical Foundations And Applied Performance Of Periodicity-Aware Imputation: Variable Bandpass Block Bootstrap Methods For Incomplete Time Series, Asmaa Ahmad

Electronic Theses & Dissertations (2024 - present)

Time series data are prevalent across a wide range of disciplines, including health surveillance, public policy, and environmental monitoring. In the presence of underlying cyclical patterns, the integrity of time series analysis depends critically on the ability to detect, model, and impute structured missing data without compromising the temporal structure. This dissertation introduces and validates a novel imputation framework that integrates the Variable Bandpass Periodic Block Bootstrap (VBPBB) into multiple imputation procedures, improving the accuracy, robustness, and interpretability of time series models under high rates of missingness and noise. The overarching goal of this dissertation was to develop and evaluate …

Photoswitchable Inhibitors Of Eaat3, Karly Suhr

Electronic Theses & Dissertations (2024 - present)

Azobenzene is a photoswitchable molecule known for its high conversion yield and repeatability. The inclusion of an azobenzene moiety with a known inhibitor of your target of interest allows for greater study of function as well as potential therapies. Three derivatives were designed from azobenzene and known inhibitor of EAATs, TBOA, to synthesize photoswitchable inhibitors of EAATs. Further investigation into the function of EAATs and development of a specific inhibitor for EAAT3, an important glutamate transporter in the brain required for proper function, can then be conducted. Photoisomerization studies on the derivatives were conducted using UV/vis spectroscopy and NMR spectroscopy. …

Stress And Resilience In Higher Education Administrators: Exploring The Role Of Mindfulness, Michael Baumgardner

Electronic Theses & Dissertations (2024 - present)

This dissertation explores stressors experienced by higher education administrators (HEAs) and examines the role of mindfulness practices in mitigating stress and fostering resilience and job satisfaction. HEAs manage essential institutional functions yet face intensifying pressures from volatile funding streams, shifting demographics, changing public perceptions, political and cultural challenges, technological disruptions, and pandemic-related change. Despite HEAs central role in sustaining higher education, limited research examines how these professionals experience stress, and even less has considered mindfulness as a potential resource for coping and resilience.

Guided by a qualitative methodological approach, this study draws on semi-structured, thick description interviews with 18 HEAs …

Y’All Means All: Pro-Choice Abortion Activism In West Texas Post-Dobbs, Hannah S. Noblewolf

Electronic Theses & Dissertations (2024 - present)

In the spring of 2021, a six-week abortion ban passed by popular vote in the city of Westerburg, Texas. It had a civil enforcement mechanism, allowing someone to collect a reward of $2,000 if they successfully sued someone they reported for “aiding and abetting” abortion. The ban, called the Westerburg Sanctuary City ordinance, was referred to as “bounty hunting.” When the ban passed it became the template for the state-level Texas Heartbeat Act, which provides a greater financial reward for a successful civil suit, with a minimum of $10,000 plus legal fees. In the face of this ban, pro-choice activists …

Essays On Technological Change And Scientific Research, Max Mayca

Electronic Theses & Dissertations (2024 - present)

The primary objective of economic science has long been to understand and promote growth, as it contributes to a more prosperous civilization and improves individual well-being. The core drivers of growth—capital accumulation, human capital development, and technological progress—are well-established. While capital deepening enables scaling of production, and human capital enhances labor productivity, technological and scientific advancements remain the most critical, as they continually redefine the efficiency frontier. Given this centrality, it is essential to understand how technological progress affects labor markets, how research resources should be allocated, and how technology relates to human capital formation.

The first part of this …

Identification Of Fentanyl And Fentanyl Analogs Found In Human Urine Using Gas Chromatography-Mass Spectrometry, Adam M. Fisher

Electronic Theses & Dissertations (2024 - present)

Identification of fentanyl and its analogs in unknown samples is a frequent practice completed in forensic crime labs, as the fentanyl epidemic continues. With the continued increase in illicit drug use, crime labs are not able to keep up with the flooding of new fentanyl analogs being developed, resulting in new analogs slipping past the crime labs’ authority. This research is to start to develop a database of commonly found fentanyl analogs in New York State. Gas Chromatography-Mass Spectrometry (GC-MS) is a widely used method for the detection and identification of illicit drugs in forensic crime labs. A database that …

Pathways To Disclosure And Treatment Among Individuals With An Attraction To Minors, Theodore Jackson

Electronic Theses & Dissertations (2024 - present)

Child sexual abuse prevention is a significant social concern in the United States and internationally. While there have been some successful efforts to reduce recidivism risk among individuals who have committed sexual offenses, we fall short when preventing first time offenses. Therefore, looking at ways to provide treatment to those who are more at-risk for a first offense seems like a potential solution to this problem. One such relevant risk-factor is attraction to minors. This study is a qualitative examination using Interpretive Phenomenological Analysis of how people who are attracted to minors make the decision to disclose their attraction, seek …

Gendered Images In Online Political Advertising Videostyles: A Case Study Of 2024 Taiwan Presidential And Parliamentary Elections, Chia-Heng Chang

Electronic Theses & Dissertations (2024 - present)

Despite the increasing visibility of female politicians in Taiwan, the resurgence of the #MeToo movement ahead of the 2024 presidential and parliamentary elections underscores the enduring influence of patriarchal norms and gender stereotypes within Taiwanese society. Prior research in political communication has documented how gendered expectations shape voters’ perceptions of politicians’ appearances, behaviors, and perceived competence in addressing political issues. These expectations, in turn, inform how candidates strategically construct their public personas during electoral campaigns. This dissertation contributes to this body of scholarship by analyzing how Taiwanese political candidates perform gender through political advertising. Integrating the videostyle framework, gender schema …

Sulfur Chemistry For Protein Synthesis And Modification: From Thiolactone To Bicyclic Sulfoxide Frameworks, Yuming Wen

Electronic Theses & Dissertations (2024 - present)

This dissertation explores two intersecting themes in modern chemical biology: (1) the design of novel ligands for transition-metal catalysis, and (2) the development of thiolactone-mediated strategies for protein synthesis and modification in aqueous media. Together, these studies advance chemical methods for precise molecular transformations under mild, biocompatible conditions.

In the first chapter, a geometrically constrained bicyclic [3.3.1] sulfoxide framework was developed as a new class of bissulfoxide ligands for palladium-catalyzed C–H functionalization. The ligand was synthesized concisely from thiophenol through a three-step sequence and shown to promote allylic C–H amination and alkylation reactions with high efficiency. The catalytic system tolerated …

I Get It From My Momma: Exploring The Process Of Transgenerational Resiliency Among Two Generations Of Single Black Mothers, Destiny A. Bender

Electronic Theses & Dissertations (2024 - present)

Abstract

Aim: This dissertation examines how resilience is transmitted across two generations of Black women (18 to 70 years of age). It aims to enhance our knowledge of the meaning of resilience in the context of single motherhood and how beliefs, values, faith-based approaches to coping, and culturally driven approaches to mothering influence outcomes for the next generation. Knowledge gaps regarding theoretical formulations of resilience and single Black mothers are discussed. Methodology: The researcher conducted in-depth interviews with ten women (five mother-daughter dyads). A phenomenological inquiry was conducted to explore the meaning-making process of resilience for mothers; human development, ecological …

Teaching Documentary Filmmaking As Social Advocacy: The Case Of The Yangon Film School, Violet Valdez, Mon Mon Myat

Department of Communication Faculty Publications

This is a descriptive case study of Yangon Film School (Yangon, Myanmar) in a setting of protracted civil conflict that has persisted since 1968. It examined the school’s approach in the teaching of documentary filmmaking and analyzed key aspects of the school’s operations. Findings show that the documentary filmmaking taught in the school was informed by social advocacy. This was fostered through the students’ participation in films commissioned to the school by civil society organizations and the practice of participatory filmmaking. The school stood out in the Myanmar setting for its dual character as a training center and a production …

Effects Of Interventions For The Prevention And Management Of Maternal Anemia In The Advent Of The Covid-19 Pandemic: Systematic Review And Meta-Analysis, John Kyalo Muthuka Dr., Diana Kageni Mbari-Fondo, Francis Muchiri Wambura, Kelly Oluoch, Japheth Mativo Nzioki, Nabaweesi Rosemary Dr

Faculty Publications

No abstract provided.

Environmentally Persistent Free Radicals Lead To Selective Inhibition Of Cyp1 Monooxygenase Activities, And Increased Production Of Reactive Oxygen Species By Reaction Uncoupling, John Patrick Connick, Amari A. Stepter, George F. Cawley, Marilyn K. Eyer, Wayne L. Backes

School of Medicine Faculty Publications

This study focuses on the effect of Environmentally Persistent Free Radicals (EPFRs) on the P450 enzymes of the CYP1 family. EPFRs are a component of particulate pollutants, that are stable in the environment, but can generate free radicals, leading to oxidative stress and subsequent toxicity of the respiratory, cardiovascular, and immune systems once they enter an organism. The results show differences in the ability of EPFRs to inhibit CYP1-dependent substrate metabolism, with CYP1B1 being inhibited to the greatest extent. There also were differences in the ability of EPFRs to disrupt the POR•CYP1 complex, with CYP1B1 being the only form where …

Chronic Administration Of A Cannabis-Derived Mixture At An Antihyperalgesic Dose Does Not Significantly Enhance Hepatotoxicity Or The Development Of Metabolic Dysfunction-Associated Steatohepatitis In Male Mice, Kim B. Pedersen, Tomislav Jelesijevic, Tamara M. Morris, Sarah M. Melton, Ashley S. Henderson, John F. Glenn, Gregory J. Davenport, Martin J.J. Ronis, Peter J. Winsauer

School of Medicine Faculty Publications

Cannabis and cannabinoid mixtures have been linked to a variety of health benefits including pain mitigation, suppression of nausea produced by chemotherapeutic agents, anti-inflammatory effects, and effects on energy homeostasis, glucose, and lipid metabolism. The latter properties have led to the suggestion that these products could have therapeutic effects on the development of metabolic dysfunction-associated steatohepatitis (MASH) - a severe type of liver pathology in obese and diabetic patients. However, varying agonist and antagonistic properties of different cannabinoids on the endogenous cannabinoid system make prediction regarding hepatic effects and diet interactions difficult. The current study was designed to examine hepatic …

Multi-Modal Neo-Adjuvant Anti-Obesity Medications May Be More Effective Than Medically Supervised Weight Loss Or Glp-1 Therapy Alone In Preparing Bmi ≥ 70 Patients For Metabolic Surgery, Michael Kachmar, Florina Corpodean, Iryna Popiv, Kyle B. Lapenna, Denise M. Danos, Michael W. Cook, Brian A. Saunders, Jean J. Domercant, Vance L. Albaugh, Philip R. Schauer

School of Medicine Faculty Publications

Background/objectives: Optimizing patients with a body mass index (BMI) ≥ 70 kg/m² for metabolic surgery (MS) is challenging. However, pre-operative weight loss may be important for improving the safety of MS for these high-risk patients. Multi-modal anti-obesity medications (mmAOM) may enhance preoperative weight loss compared to non-pharmacologic medically supervised weight loss (NP-MSWL) or glucagon-like peptide-1 receptor agonist monotherapy (Mono-GLP-1) alone. Subjects/methods: This retrospective study analyzed 113 patients with BMI ≥ 70 kg/m² at a single metabolic disease treatment institute. Interventions/methods: Patients were categorized into NP-MSWL (n = 13), Mono-GLP-1 (n = 54), and mmAOM (n = 46) groups. The primary …

Advancing Special Needs Oral Healthcare In Southeast Asia Through Taiwan's New South Bound Project: Institutional Feedback And Sustainable Strategies, Chuan-Hang Yu, Chia-Tze Kao, Tsui-Hsien Huang, Ming-Yi Lu

Journal of Dental Sciences

Abstract Background/purpose Providing oral healthcare to individuals with special needs remains inadequate in Southeast Asia. This study evaluated the outcomes from five universities across three Southeast Asian countries participating in Taiwan's “New South Bound Special Needs Patients Oral Care Project” after its four-year implementation (2018–2021). Materials and methods The questionnaires distributed to participating universities collected data on dental professionals' demographics, patient characteristics, and project satisfaction. Descriptive statistics analyzed the responses. Results All universities reported excellent satisfaction with the project. Dental professionals’ ages ranged from 31 to 60 years, and their service experience varied from 1 to 10 years. Special needs …

Tomatoes, Sea Cucumbers, And Ai. Conceptualizing A Casual Loop Diagram For Assessing Challenges And Opportunities Of The Urban Ocean, Elisa Fernández Ramos, Andrés Jaque Ovejero, Eva Hurtado Torán, Oz Sahin

Capítulos de libros

Could the combination of tomatoes, sea cucumbers, and AI be the glocal recipe for sustainable urban development systems? In this text, we review some of the implications of oceanic expansion, proposing an experiment to extract these and other conclusions that may help us realize its importance and the role of architects and urban designers in it. This research assumes that the coastline is fictitious, just like the boundary of cities that usually coincides with it. The city is part of the marine ecosystem and sprawls over it, primarily for productive purposes. Productivity models have shaped our cities since the beginning …

From Lithuania To Mobile: An Immigrant’S Memoir Comes To Light, Deborah Gurt

University Faculty and Staff Publications

No abstract provided.

Methyl-Cpg-Binding Domain As A Protein Interaction Partner In Promoter Regulation And Neurodevelopment Through Evolutionary Expanded Entanglement, Stephanie M. Bilinovich, Surya B. Chhetri, Jackson T. Mitchell, Gage O. Leighton, Vladislav Jdanov, Jacob K. Zieba, Taylor W. Cook, Krysta L. Engel, Robert M. Vaughan, Humza Bhatti, Sadie L. Heeringa, Amy M. Wilstermann, Sophie Vanderweele, Akansha S. Das, Emily C. Sherry, Stephen A. Duncan, Katie L. Uhl, David C. Hinds, Mark Mackiewicz, Sarah K. Meadows, Kimberly M. Newberry, E. Christopher Partridge, Sara G. Cline, C. Joy Shepard, D. Casey Smith, Antonio Bradley, Daniel Vogt, Daniel B. Campbell, Lucas Pozzo-Miller, Caleb P. Bupp, Austin J. Goodyke, Surender Rajasekaran, Rebecca C. Knickmeyer, Benjie Blair

Research, Publications & Creative Work

There is increasing evidence that the methyl-binding domain (MBD) is a protein-protein interaction motif that can function independently of methylated DNA binding. The MBD proteins found throughout plants and invertebrates duplicated into multiple vertebrate DNA and non-DNA-binding members (MBD1, MBD2, MBD3, MBD4, MBD5, MBD6, MECP2, BAZ2A, BAZ2B, SETDB1, andSETDB2). Although many invertebrate species possess MBD proteins that can bind and recognize DNA methylation, the DNA-binding function has been independently lost multiple times, with only minor alterations to the protein interaction residues. The nucleosome remodeling and deacetylase (NuRD) complex, which interacts with MBD2/3 and is colocalized with MBD1/4 ChIP-Seq, is maintained …

Master Of Social Work Portfolio, Kinley Mae Pope

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Accurate Body Weight Class Prediction From Mirna And Gene Expression In Blood And Saliva Samples, Kimberly Lettner

Master of Science in Forensic Science Directed Research Projects

miRNA interference on protein abundance related to glucose uptake and lipid production has been evaluated in biomedical research and linked to metabolic disorders like severe obesity. The direct regulation of protein abundance caused by miRNAs on a person’s metabolism can lead to an increased weight and overall size. Body size, measured by BMI, provides additional physical descriptions that can be combined with hair color, eye color, age, and skin pigment to aid investigations of unidentified remains or unknown suspects not found in a database. The purpose of this project was to evaluate the miRNA expression of target biomarkers in dried …

Enhancing Engagement In Cardiovascular Risk-Reducing Behaviors Through Motivational Text Messaging (Mtm) In An Underserved Population Of Memphis, Tennessee, Lindsey H. Dao

DNP Projects

Enhancing Engagement in Cardiovascular Risk-Reducing Behaviors Through Motivational Text Messaging (MTM) in an Underserved Population of Memphis, Tennessee

The Impact Of Teaching Students Stress And Trauma Alleviation Techniques For Coping With Distressing Materials In First-Year Composition, Faye Monique Scott

Graduate Research Theses & Dissertations

Trauma can impact the way a student learns and focuses. In higher education, without instructors realizing it, classes may retraumatize or trigger students with the texts, media, or materials utilized. Research suggests that little attention is given to helping students deal with potentially traumatizing course materials and students inside the classrooms may be impacted by trauma whether the teacher is aware or not. This dissertation examined the effects of teaching students specific coping strategies—Trigger Warnings (TWs) and Stress and Trauma Alleviation Techniques (STATs) —while reading, writing, and reflecting on possibly distressing materials in First-Year Composition courses through a mixed methods …

Functional Characterization Of The Hdt5 Gene In Aspergillus Flavus Morphogenesis, Mycotoxin Production, And Fungal Phytopathogenicity, Brenda Omburo

Graduate Research Theses & Dissertations

The present study aimed at elucidating the role of hdt5 in fungal morphology, mycotoxin production and in plant virulence in Aspergillus flavus. Currently, methodologies to prevent the negative impact of A. flavus are insufficient. It is known that expression of the hdt5 gene is dependent on hbx1, a master regulatory gene that affects expression of hundreds of genes in the A. flavus genome, controlling both development and secondary metabolism. However, while the aflatoxin gene cluster has been elucidated, the genetic regulatory mechanisms controlled by hdt5 are not fully understood. For this study, therefore, a complete strain set composed of a …

An Analysis Of Mental Health And Workplace Absenteeism, Kristin Marie Vrona

Graduate Research Theses & Dissertations

This dissertation examines the effect of mental health on own health-related absenteeism among employed adults in the United States, using data from the 2010–2014 Medical Expenditure Panel Survey (MEPS). The MEPS uniquely differentiates between absences due to one’s own health and those due to another person’s health, enabling causal estimation of individual-level factors influencing absence decisions.

The analysis incorporates both mental and physical health measures, including diagnostic indicators and self-reported general well being, which are used as proxies for severity that may affect both diagnosed and undiagnosed individuals. Results reveal a consistent pattern: individuals experiencing high psychological distress but lacking …

Water Quality And Microplastic Contamination In An Urbanizing City Nakhon Pathom, Thailand, Boonyarak Chuanchit

Graduate Research Theses & Dissertations

Microplastics (MPs) are synthetic polymer particles less than 5 mm in size that originate from both primary manufacturing and the breakdown of larger plastics. Extensive studies have examined their occurrence in other environments, while little is known about their presence and behavior in groundwater, especially in urbanizing regions in Southeast Asia. This study investigates the occurrence and abundance of microplastics within groundwater systems of Nakhon Pathom, an urbanizing province in central Thailand.

Groundwater was collected representing shallow and deep aquifers between May 2023 and May 2025. The analyses included physical-chemical parameters, major ions, heavy metals, and microplastic abundance and composition. …

An Exploration Of Social Isolation’S Effects On The Gastrointestinal And Metabolic Health Of A Social Mammal, Daniel Adam Nuccio

Graduate Research Theses & Dissertations

Human health can be impacted considerably by subjective feelings of loneliness, resulting in mental illness and the dysregulation of normal cardiovascular, immune and endocrine functioning. This occurs because social isolation serves as a form of chronic stress for social mammals, spurring physiological responses akin to those associated with more standard forms of stress. On account of their highly social nature, prairie voles (Microtus ochrogaster) subsequently have become one of the model organisms of choice for investigating the effects of social isolation on the development of disease in social mammals.

This dissertation seeks to expand the scientific community’s understanding of the …

Audit Culture And A Nonprofit In Northern Illinois, Onyenum Ruth Udoh

Graduate Research Theses & Dissertations

Audit culture has become a defining feature of nonprofit life, shaping how organizations balance accountability to donors with responsibility to their communities. While existing scholarship often highlights large or international NGOs, less is known about how small and mid-sized nonprofits in the United States experience these pressures. This study focused on nonprofit in DeKalb County, Illinois, to examine how audits, donor restrictions, and accountability demands influence nonprofit practices, priorities, and relationships with their communities. Grounded in ethnographic fieldwork and organizational anthropology, I conducted eight weeks of participant observation and semi-structured interviews with seven staff across leadership, finance, program, and administrative …