Digital Commons Network^™

Strengthening The Preservation Ecosystem For Below-Market-Rate Housing In Santa Cruz, Bennett Williamson

Master's Projects

In Santa Cruz, California, policies and political movements of the last fifty years have both prevented sprawl and stymied the construction of new infill housing. As a result, today Santa Cruz is one of the most expensive housing markets in the nation, and the lack of available affordable housing has led to incredibly high rent burdens for the majority of the population, putting residents at risk of displacement through landlord action or market forces. This report assesses the efficacy of preserving existing affordable housing as an anti-displacement strategy in Santa Cruz. It uses key stakeholder interviews with local housing practitioners …

Nontraditional Students Enrolling In Online Education: Assessing Outcomes And Barriers To Success, Kua Vang

Master's Projects

Online education has significantly reshaped how colleges and universities define and evaluate academic achievement. In March 2020 during the height of the Covid-19 pandemic, the U.S. government enforced social distancing regulations that affected operational continuity for higher education institutions. The need to transition from traditional classroom instruction to online was unavoidable. Institutions were not prepared, however, and their shortcomings in providing high-quality online learning for students were exposed. The inadequacy can be due to higher education institutions decade-long mindset of seeing online education as a less credible alternative. As a result, institutions are more eager than ever before to invest …

Collaborative Governance In Practice: Evaluating Intergovernmental Relations Through The Santa Clara County Healthy Cities Initiative, Astrid J. Robles

Master's Projects

In the United States, intergovernmental relations (IGR) is rooted in the principles of American federalism, which focuses on the constitutional power dynamics between national, state, and local governments. While federalism outlines the structural framework, IGR specifically focuses on how federal, state, and local governments interact administratively, financially, and politically within the federal system. Beginning in the 1960’s, governments across the U.S. began to rely on non-governmental and private sector organizations for program implementation (Boyd & Fauntroy, 2000). This shift gave rise to the concept of collaborative governance, which expanded the scope of IGR by incorporating traditionally excluded groups from the …

Advanced Knowledge Extraction With Biomedical Data Using Llms, Akshat Krishna

Master's Projects

The rapid growth of biomedical research has led to an overwhelming volume of unstructured textual data in the scientific literature. This has necessitated the development of an automated approach for knowledge extraction and integration. In

this project, we present a comprehensive pipeline for constructing a unified biomed- ical knowledge graph by combining two well-known datasets: CHEMPROT [1],

which captures chemical–protein interactions, and EU-ADR [2], which annotates drug–gene–disease relationships. In order to identify important biomedical entities and interactions from CHEMPROT dataset, we perform Named Entity Recognition (NER) and relation Extraction (RE) using state-of-the-art biomedical models like BioBERT [3], BioGPT [4] and …

Why We Need To Fill In Our Mixed-Use Communities’ Business Vacancies And How We Can Do That, Victor Huynh

Master's Projects

This planning report provides an in-depth exploration as to why so many mixed use communities, including transit-oriented developments, in metropolitan regions across the country are facing challenges with filling in their retail business vacancies at the ground floor. It also provides a current snapshot of best practices to remedy this widespread barrier to cities functioning more effectively and sustainably. This report provides a combination of findings from a literature review which identifies the most common reasons and remedies for business vacancies, and a research design which identifies which urban planning or urban design characteristics correlate most frequently with case sites …

Equity In Public Budgeting: Community Engagement In Morgan Hill, Ariana Perez

Master's Projects

Through this research, I will examine what citizen participation strategies have been implemented and their role and effectiveness in addressing wealth inequities. My research will explore these topics and examine what programs and policies the City of Morgan Hill can implement to increase residents' sense of belonging and ultimately push for greater social equity. My primary research question is, what are the programs and policies that the City of Morgan Hill can implement to engage immigrant communities, specifically Spanish-speaking residents, and low-income residents in shaping decisions around public investments and funding? This project will serve as a needs assessment to …

Caveolin-Mediated Endocytosis: Bacterial Pathogen Exploitation And Host-Pathogen Interaction, Dibyasri Barman, Rishi Drolia

Biological Sciences Faculty Publications

Within mammalian cells, diverse endocytic mechanisms, including phagocytosis, pinocytosis, and receptor-mediated endocytosis, serve as gateways exploited by many bacterial pathogens and toxins. Among these, caveolae-mediated endocytosis is characterized by lipid-rich caveolae and dimeric caveolin proteins. Caveolae are specialized microdomains on cell surfaces that impact cell signaling. Caveolin proteins facilitate the creation of caveolae and have three members in vertebrates: caveolin-1, caveolin-2, and caveolin-3. Many bacterial pathogens hijack caveolin machinery to invade host cells. For example, the Gram-positive facultative model intracellular bacterial pathogen Listeria monocytogenes exploits caveolin-mediated endocytosis for efficient cellular entry, translocation across the intestinal barrier, and cell–cell spread. Caveolin …

Zika Virus Modulates Arthropod Histone Methylation For Its Survival In Mosquito Cells, Telvin Harrell

Biological Sciences Faculty Publications

Zika virus (ZIKV) is a mosquito-borne human pathogen that causes mild febrile illness in adults and severe neurological complications and microcephaly in newborns. Studies have reported that ZIKV modulates methylation of human and viral RNA critical for its replication in vertebrate cells. In this study, we show that ZIKV modulates mosquito S-adenosyl methionine (SAMe)-synthase, an enzyme involved in the production of SAMe (methyl donor), and histone methylation for its survival in mosquito cells. Reverse transcription quantitative PCR followed by immunoblotting analysis showed increased amounts of SAMe synthase at both RNA and protein levels, respectively, in C6/36 mosquito cells infected with …

Validating A Novel Capability Of Assessing Pathways Of Animal Water Gain And Loss, Zachary T. Steele, Karen Caceres, Zachary A. David, Lisa M. Shollenberger, Alexander R. Gerson, Seth D. Newsome, John P. Whiteman

Biological Sciences Faculty Publications

Understanding variations in the routes by which wild animals gain and lose water is challenging, and common methods require longitudinal sampling, which can be prohibitive. However, a new approach uses Δ′¹⁷O_BW (Δ′¹⁷O of animal body water), calculated from measurements of δ′¹⁷O and δ′¹⁸O in a single sample, as a natural tracer of water flux. Δ′¹⁷O_BW is promising, but its relationship to organismal variables such as metabolic rate and water intake have not been validated. Here, we continuously measured oxygen influxes and effluxes of captive deer mice (Peromyscus maniculatus), and manipulated their water intake and metabolic rate. We used …

Heterotrophy Of Particulate Organic Matter Subsidies Contributes To Divergent Bleaching Responses In Tropical Sclaractinian Corals, Connor R. Love, Kelly E. Speare, Michael D. Fox, Veronica Z. Radice, Kelton W. Mcmahon, Gretchen E. Hofmann,, David L. Valentine, Marie E. Strader

Biological Sciences Faculty Publications

Heterotrophic feeding on plankton and particulate organic matter (POM) by tropical Scleractinian corals is known to aid in the resistance and recovery from thermally induced bleaching. However, the relative importance of heterotrophy in promoting bleaching resistance and recovery is likely to vary based on ecological context and the severity of heat stress. In 2019, the Pacific Island of Mo'orea experienced mass coral mortality during a widespread marine heatwave. Many Acropora hyacinthus colonies on the shallow reef slope (5 m) were resistant to bleaching, while colonies on the deeper fore reef (14 m) often bleached and subsequently recovered, despite similar thermal …

Schistosoma Mansoni Infection Causes Consistent Changes To The Fecal Bacterial Microbiota Of Mice Across And Within Sites, Mariam A. Mhanna, David T. Gauthier, Lisa M. Shollenberger

Biological Sciences Faculty Publications

Eggs of Schistosoma mansoni are produced by adult female worms in mesenteries of infected hosts. Eggs can cross the intestinal barrier and form granulomas in the tissue or breach and exit the host through fecal excretion. These interactions may affect the host microbiome assemblages. Given the potential for schistosomal alteration of host gut microbiome and subsequent effects on the fecal bacterial composition, it is important to conduct controlled microbiome studies on model animals. While pursuing these studies, it is important to take into account the different conditions in which microbiome studies are conducted and their consequent impacts on variability and …

Addressing The Productivity-Susceptibility Analysis In Data-Limited Fisheries For Understudied Fish In The Marine Aquarium Trade, Alice Wynn, Jemelyn Baldisimo, Gabrielle Baillargeon, Michael Tlusty, Andrew Rhyne

Biological Sciences Faculty Publications

The marine aquarium trade (MAT) harvests millions of coral reef fishes from the wild yearly. While the MAT supports fishers, hobbyists and marine education, harvested fishes are crucial in maintaining coral reef health and balanced marine cycles within their native habitats. Understanding the impact of the MAT on fish populations is critical for sustaining the trade in the long-term. Productivity-susceptibility analyses (PSAs) offer semiquantitative methods of analyzing the productive capacity of each fish stock, as well as its susceptibility to overfishing. The present study revises and expands upon a PSA conducted by Baillargeon et al. (2020) that focused on 32 …

Dengue Virus Modulates Critical Cell Cycle Regulatory Proteins In Human Megakaryocyte Cells, Swarnendu Basak, Shovan Dutta, Supreet Khanal, Girish Neelakanta, Hameeda Sultana

Biological Sciences Faculty Publications

Suppression of human megakaryocytes by dengue virus (DENV) infection significantly reduces the platelet count that eventually leads to thrombocytopenia, severe dengue and death. To understand DENV interactions with megakaryocytes, we investigated the cell cycle in leukemic human megakaryocytic in vitro cell line (MEG-01 cells). Megakaryocytes are known for complex endomitotic cell cycle leading to their polyploidy state. Our study shows that DENV uses these polyploid cells for its replication. Understanding the modulation of DENV-mediated cell cycle regulation in megakaryocytes is therefore highly important. We show that DENV2 (serotype 2) infection significantly modulates cell cycle signaling. Our protein profile microarray data …

Analyzing Microbial Communities In Porites Astreoides, Sanaa Caldwell, Katie Parker, Daniel Barshis

Biological Sciences Faculty Publications

Coral reefs are vital marine ecosystems that support many different species and ecosystem services through protecting coastlines from storms and erosion, providing raw materials for medication, and facilitating diversity amongst marine species. Anthropogenic climate change is causing ocean temperatures to exceed the range of coral thermal tolerance resulting in more coral bleaching events globally. However, some corals have the capacity to withstand high temperatures through different thermal tolerance strategies. A balanced microbial community plays a critical role in coral health and recent studies have indicated that a balanced microbiome is associated with temperature-stress tolerant corals. Yet, there is a severe …

Herpetofauna Richness, Diversity, And Occurrence At The Northern Ecotone Of Longleaf Pine, Julianne Jones, Dylan Bryant, Erik Yando

Biological Sciences Faculty Publications

Habitat suitability commonly differs between the core and periphery of ecosystems. The longleaf pine ecosystem is recognized for its value in providing habitat to a variety of specialist and endemic species, especially herpetofauna. However, at the northernmost extent of longleaf pine (in southeastern Virginia) little is known about the denizen reptiles and amphibians. Moreover, the remaining longleaf pine ecosystem at the latitudinal ecotone is fragmented amongst a mosaic of other ecosystems. We examined herpetofauna diversity, richness, and capture rates between four focal habitat types—mature longleaf pine, restored longleaf pine, maple-gum swamp, and pocosin-bog—in the Zuni Pine Barrens of southeastern Virginia. …

Form And Function In Mobulids: A Comparative Analysis Of Filter Morphology With Bioinspiration Applications, J. B. Teeple, S. R. Kahane-Rapport, K. E. Cohen, L. Hamann, J. A. Strother, E. W. M. Paig-Tran

Biological Sciences Faculty Publications

Mobulas (manta and devil rays) are large-scale ram filter feeders that separate planktonic food particles from large volumes of water with minimal clogging. This contrasts with most human-made filters that can suffer from problematic clogging requiring additional mechanisms for clearing blocked surfaces and maintaining performance. Prior studies have shown that mobulas employ a unique mechanism referred to as ricochet separation to filter feed, whereby captive vortices in filter pores cause particles to bounce off the filter surfaces and away from the filter pores. This mechanism enables the filtration of particles smaller than the pore size and reduced clogging. However, few …

Decoding Tattoo And Permanent Makeup Pigments: Linking Physicochemical Properties To Absorption, Distribution, Metabolism, And Elimination Profiles Using Quantitative Structure-Activity Relationship (Qsar)-Based New Approach Methodologies (Nams), Girija Bansod, Ajay Vikram Singh, Preeti Bhardwaj, Tulika Rai, Sweta Vijay Nakhale, Amruta Shelar, Rajendra Patil, Peter Laux, Andreas Luch, Christopher J. Osgood, Michael W. Stacey

Biological Sciences Faculty Publications

The safety and quality of tattoo and permanent makeup (PMU) pigments are subject to increased scrutiny due to their potential to cause adverse effects like anaphylaxis, photoallergic responses, and long-term toxicity. These undesirable reactions governed by their chemical structure possess varied physicochemical properties and absorption, distribution, metabolism, and elimination (ADME) characteristics. These properties control the pigment behavior during application, stability, and interaction with human tissue. The correlation between these physicochemical characteristics and ADME parameters of tattoo/PMU pigments remain under-explored despite the current advances in toxicology. Our study aims to address and bridge the gap by leveraging open-access QSAR computational toxicology …

Description Of All Stages Of A New Tick Species From California Haemaphysalis Vespertina (Acari: Ixodidae), With Redescription Of H. Leporispalustris Packard, 1869 Adults And Phylogenetic Relationships Among Related U.S. Taxa, Andrea Egizi, Santiago Nava, Angie Nakano, Megan E. M. Saunders, Lauren P. Maestas, Autumn D. Angelus, Bruce Noden, Robyn M. Nadolny, Waheed I. Bajwa, Charles Lubelcyzk, Chanakya R. Bhosale, Susan Paskewitz, Holly D. Gaff, Lorenza Beati

Biological Sciences Faculty Publications

All active stages of Haemaphysalis vespertina sp. nov. (Acari: Ixodidae), a tick previously identified as H. leporispalustris Packard, 1869, are described from specimens collected on the vegetation and from leporids in California and Oregon. The adults of H. leporispalustris Packard, 1969 are redescribed based on type material. Adults of the two species can be distinguished by their overall size, the dorsal shape of palpal segment II, the number and shape of dorsal and ventral setae on palpal segment II, the number of spurs on coxae II, the length of setae on scutum, legs and coxae, and the pattern of scutal …

Tick Responses To Diverse Chemical Attractants To Enhance Tick Surveillance Methods' Efficacy, Pamela Kelman, Tyler Chavers, Emily Owens Pickle, Daniel Sonenshine, Melissa S. Nolan, Holly Gaff

Biological Sciences Faculty Publications

Amblyomma maculatum Koch (Acari: Ixodidae), Ixodes scapularis Say, and Dermacentor variabilis Say are three hard-bodied ticks responsible for vectoring pathogens that cause most human tick-borne diseases in the United States of America (USA). Tick surveillance is critical to elucidate high-risk areas for targeted vector control and public health interventions. Despite tick-borne diseases having a higher annual incidence compared to mosquito-borne diseases in the USA, tick traps used for surveillance are grossly under-developed compared to the suite of sophisticated mosquito traps available on the commercial market. This study sought to identify potential prospective tick trap improvements by evaluating the relative attraction …

Hair Growth Rate Estimation In North American Ursids, Jennifer H. Stern, Karyn D. Rode, Craig A. Stricker, Sheriden Ploof, Cindy L. J. Roberts, Celess Edinger, Mary Humbyrd, Nate Wagner, Megan A. Owen, John P. Whiteman, Thea Bechshoft, Brent White, Kristin L. Laidre

Biological Sciences Faculty Publications

The feeding ecology of wildlife populations has important implications for individual health, population productivity and distribution patterns. For ursids (bears), food resources and feeding behaviour primarily affect population dynamics via effects on cub production and survival. Much of what is known about the feeding ecology of bears is based on analyses of tissues collected from capture-based research efforts, harvested animals or non-invasive approaches. However, inference about diet from hair has been limited by a lack of quantitative data on the timing of the moult and hair growth rates. We conducted a study to develop and test two methods of quantifying …

Investigating The Relationships Between Biotic And Abiotic Factors Affecting Migratory Behavior In Westslope Cutthroat Trout Within The Pend Oreille System, Garrett M. Duncan

EWU Masters Thesis Collection

Salmonids express several different life histories from migrating to oceans and back or staying in their natal streams as a resident. Migratory individuals are a vital part of the overall success of populations due to the potential for increased genetic diversity and increased fecundity they offer over resident individuals. This research was completed in three basins including Priest River, Pack River, and Lightning Creek which are all connected to the Pend Oreille Basin and are important producers of Westslope Cutthroat Trout (Oncorhynchus clarkii lewisi). Thirty-nine sites were sampled between the three basins. Results were compared between these tributaries that have …

Osteoclastogenic Potential Of Cd68-Expressing Osteoclast Precursor Cells, Colton Quinn

EWU Masters Thesis Collection

Bone remodeling is a dynamic process maintained by the balance between osteoblast-mediated bone formation and osteoclast-driven resorption. When this balance is disrupted, pathological bone loss occurs, as seen in osteoporosis, rheumatoid arthritis, and cancer-induced bone disease (Teitelbaum, 2007; Korol & Baumeister, 2023; Ensrud & Crandall, 2017). Osteoclasts, derived from hematopoietic stem cells through a macrophage lineage, play a central role in bone resorption. However, the identity of all proteins of osteoclast precursors remains unclear. CD68, a lysosomal glycoprotein widely expressed in macrophages and monocyte-lineage cells (Holness & Simmons, 1993), has been proposed as a marker of osteoclast precursors. Some studies …

London's Murderous Mothers: How Charitable And Medical Advancement Influenced Infanticide Indictments During The Long 18th Century, Brandon Gamman

EWU Masters Thesis Collection

No abstract provided.

Invisible Infrastructure: Beyond The Burden Of The Dual Roles And Systematic Realities Of Black Women Professionals As Caregivers, Lolita J. Griffin

West Chester University Graduate Theses, Dissertations, and Final Projects

Black women in the professional sector frequently serve as caregivers to close relatives or family members while balancing the demands of their careers. Research shows the hurdles and the stress Black women in the workforce encounter. (Office of Behavioral Health Equity, 2020). Similarly, the expectation to take on the caregiver role adds another layer of complication to their existence (Williams et al., 2021). This combination of conflicting caregiver and professional responsibilities can cause harm to overall well-being and mental health. The enactment of reforms in public policy that address the specific mental health and job satisfaction needs of Black professional …

The Impact Of Age-Friendly Policy On New York State: How Executive Order-190 And Executive Order-23 Shape Community Development For All Ages, Trista Bercarich

West Chester University Graduate Theses, Dissertations, and Final Projects

The demographic shift toward an aging population has created an urgent need for policies that promote inclusive, livable communities for all ages. This quantitative study examined New York State’s implementation of Age-Friendly policy through Executive Order 190 (2018) and Executive Order 23 (2022), which collectively advance the integration of health, accessibility and community participation across state and local systems. Guided by environmental gerontology and psychology, aging in place and successful aging frameworks, this research utilized an adapted version of the AARP Livable Communities Survey to assess residents’ perceptions of livability with the eight AARP domains. The cross-sectional online survey (n …

Environmental Risk Factors For Highly Pathogenic Avian Influenza In Pennsylvania’S Commercial Poultry Industry, Andrew Turner

West Chester University Graduate Theses, Dissertations, and Final Projects

This study examines environmental risk factors associated with outbreaks of Highly Pathogenic Avian Influenza (HPAI) H5N1 clade 2.3.4.4b in Pennsylvania’s commercial poultry industry. Using a case-control design, the analysis evaluates 2,285 geocoded commercial poultry farms through spatial and biostatistical methods aligned with STROBE-Vet reporting guidelines. A broad set of 641 GIS-derived candidate variables, including farm characteristics, bird types, disease incidence, wild bird observations, anthropogenic features, socio-economic indicators, and ecoclimatic conditions, were screened for associations with HPAI infection. The logistic regression model identified the density of infected farms within short distances and the local concentration of duck farms as the strongest …

What We Owe Each Other: An Examination Of Social Exchange Theory And Public Perception Of Healthy Relationships, Sarah R. Korbich

West Chester University Graduate Theses, Dissertations, and Final Projects

This study uses prior literature on social exchange theory and uses various frameworks to examine the public’s perception and comprehension of SET through examining user-generated content on TikTok. Social exchange theory is based upon the idea that when interacting with other persons, you are exchanging rewards and costs. This study was guided by two questions that explore how social exchange is generalized and understood by the public, and how well the public’s ideas of positively contributing to a healthy relationship aligns with operational measures of SET. This study’s intention is to encourage SET’s usage in application to relational contexts as …

An Exploratory Study Of Ukrainian Refugee Resettlement Patterns And Education Resource Needs In Poland, Marta Gintowt

West Chester University Graduate Theses, Dissertations, and Final Projects

The ongoing Russian invasion of Ukraine that started in late February 2022 triggered a refugee crisis that reverberated throughout Europe. During the onset of the invasion, an estimated five million Ukrainian refugees, mostly women, children, and the elderly, fled to countries in Europe and beyond. Countries were not prepared for the magnitude of the initial influx of refugees, who are a vulnerable population who require specific immediate and long-term supports. As three years have passed since the start of the war, the needs of refugees have evolved, and resources providing educational support to refugee children have taken on increased importance. …

Health Center Patient Satisfaction: Pre, During, And Post Covid-19, Patricia A. Stroup, Patricia Stroup

West Chester University Graduate Theses, Dissertations, and Final Projects

This study aims to evaluate patients' attitudes toward healthcare services in a predominantly Hispanic population at an urban health center serving a significantly disadvantaged population.  This center is in one of the poorest areas of the city and has one of the highest diabetes rates in the nation. For over 50 years, Federal health centers have provided care to inner-city, rural, homeless and public housing residents. They provide care to vulnerable populations that would not otherwise be available in medically underserved communities. Central to overcoming disparities is assuring patient satisfaction with their healthcare. This study evaluates patients' satisfaction with the …

Mapping Learning In Higher Education: The Embedding Content Across Academic Programmes Toolkit, John Pierce, Mary Beades, Andrew Shields

Publications

The growing diversification of teaching roles in higher education and the siloed nature of semesterised programmes can inhibit quality teaching and learning. This paper introduces the Embedding Content Across Academic Programmes Toolkit (ECAAPT), a practical model for mapping and tracking embedded content across modules, semesters, and years within higher education programmes that can ease the administrative burden of curricular mapping and change on academics teaching in the sector. Originally developed with a focus on tracking student academic literacies, this model has also been adapted and shown value in mapping and tracking other content, such as graduate attributes, feedback, assessment strategies, …