Digital Commons Network^™

Induced Reduction Of N-Glycosylation Leads To Heart Failure, Anthony M. Young

Browse all Theses and Dissertations

Cardiovascular disease is the leading cause of death and contributes to the increasing global prevalence of heart failure (HF). N-glycosylation is a common co-/post-translational modification where branching oligosaccharides are bound to the extracellular domain of membrane proteins. This creates a diverse range of glycan structures and requires the coordination of hundreds of regulated genes. Inherited mutations in glycan synthesis frequently present with cardiomyopathies leading to HF with reduced ejection fraction (HFrEF). Additionally, gene expression studies of HFrEF patients have shown altered expression of glycosylation-related genes, including alpha-1,3-mannosyl-glycoproten 2-beta-N acetlyglucosaminyltransferase (Mgat1). This gene encodes N-acetylglucosaminyl transferase 1 (GlcNAcT1) which is required …

A Secure Ml-Assisted Framework For Resilient And Efficient Prediction Of Physiotherapy Sequence In Bilateral Carpal Tunnel Syndrome, Pratik Pandurang Kharat

Browse all Theses and Dissertations

Bilateral idiopathic carpal tunnel syndrome (CTS) is a neuromuscular disorder characterized by compression of the median nerve at both wrists, leading to symptoms such as pain, numbness, tingling, and muscle weakness. Unlike unilateral cases, bilateral idiopathic CTS presents distinct therapeutic challenges due to the simultaneous involvement of both hands and the lack of an identifiable underlying cause. This study explores the application of machine learning techniques to predict the optimal sequence of physiotherapeutic interventions Stretching followed by Myofascial Mobilization (S/M) or the reverse (M/S) in female patients with bilateral idiopathic CTS and right hand dominance. Data were drawn from a …

The Impact Of Ahr And Hs1.2 Enhancer Genetic Variations On Igh Expression And Antibody Production In Human B Cells, Mili Santosh Bhakta-Yadav

Browse all Theses and Dissertations

Antibody production is an essential component of the immune response against pathogens. The immunoglobulin heavy chain (IgH) gene codes for the heavy chain of antibodies. The IgH constant regions Cμ, Cδ, Cγ1-4, Cα1-2, and Cε encode the five major classes of antibodies, i.e., IgM, IgD, IgG1-4, IgA1-2, and IgE, respectively. The transcription of the IgH gene and class switch from IgM to other isotypes is regulated by two 3’ IgH regulatory regions (3’IgHRRs), each of which is a cluster of three enhancer regions (hs3, hs1.2 and hs4). The genetic variations in the hs1.2 enhancer have been identified; a ~53 bp …

Characterizing The Microvesicle Particles From Keratinocytes Stimulated With Multiple Stressors, Muslima Begum

Browse all Theses and Dissertations

Many types of environmental and physical stressors act upon the skin and can initiate inflammation, systemic effects, and even damage to internal organs. Recent studies have identified that these harmful events are driven by the release of subcellular microvesicle particles (MVPs), an inflammatory process promoted by the glycerophosphocholines-derived lipid mediator, Platelet-activating Factor (PAF). These harmful effects are driven by the release of MVPs, a process promoted by the inflammatory lipid mediator, PAF. We have previously demonstrated that exposure of human HaCaT keratinocyte and mouse skin to stressors such as thermal burn injury, ultraviolet B (UVB) radiation, and topical photodynamic therapy …

Wrongful Birth After Dobbs And The Limits Of Tort Law In Areas Of Dissensus, E. Travis Ramey

Articles

As the abortion debate has raged in this country, a secondary debate over wrongful birth has accompanied it. Wrongful birth is a medical-malpractice-like claim brought by parents who allege that a medical provider negligently failed to provide accurate information about the fetus and that had they received accurate information they would have terminated the pregnancy. Courts rejected the tort theory until Roe v. Wade was decided. Post-Roe, courts were heavily divided over whether to recognize the claim and what damages were recoverable. Now, after Dobbs v. Jackson Women's Health Organization, the continued viability of wrongful birth is in question, and …

Rejecting The Racialization Of Indianness, Andrea J. Martin

Faculty Scholarship

No abstract provided.

Promoting Financial Empowerment Via 401(K) Plan Domestic Abuse Victim Distributions, Samantha Prince

Faculty Scholarship

Domestic violence is sadly and shockingly all too prevalent in the United States. According to the U.S. Centers for Disease Control, more than one in four women and one in seven men in this country are subject to domestic abuse “affecting an estimated 10 million people every year.”

Finances and financial abuse play a significant role in 99% of domestic abuse cases. “[L]acking financial knowledge or resources is the number one indicator of whether a domestic violence victim will stay, leave, or return to an abusive relationship.”When abusers have control over financial assets, victims are monetarily paralyzed and have little …

Taking From The Most Vulnerable: Legal Implications Of Seizing Federal Benefits From Foster Kids, Lucy Johnston-Walsh

Faculty Scholarship

Foster youth in some states are paying the cost of their own room and board when state and local government agencies seize a child's federal social security benefits to cover the costs of care. Other states, however, have passed laws forbidding such a practice, allowing youth to save these funds for their own financial needs. Federal social security benefits are an individual's own property and should not be taken without adequate notice, nor without an opportunity to challenge the taking. Tet too many youth who are involved in the foster care system are unaware they are even receiving benefits and …

Embracing A New Approach To Academic Success: How The Adoption Of A Growth Mindset Can Enhance Legal Education, Titichia M. Jackson

Faculty Scholarship

No abstract provided.

How Can We Go Far Together In Healthcare Education And Training?, Nader Nadershahi

Journal of the American College of Dentists

“If you want to go fast, go alone. If you want to go far, go together.” This African proverb highlights the importance of collaboration and cooperation to achieve long-term success and impact. This sentiment applies to many aspects of life, and it certainly applies to our reflection on the importance of breaking down the silos that have developed in healthcare. Our healthcare system has been siloed in all aspects, including delivery models, payment systems, education, and training.

Taking The Temperature: What The Acd 2025 Survey Reveals, Mike Graham, Suzan Pitman

Journal of the American College of Dentists

The American College of Dentists surveyed its Fellows to help leadership better understand how our Fellows perceive and interact with the College. The results will be used to determine organizational priorities and help guide the continued implementation of the strategic plan. The key takeaways of the survey were that (1) the 2023 Strategic Plan implementation is on the right track, (2) Fellows value their connection to the ACD, (3) communication between the organization and Fellows has improved, and (4) leadership and staff must continue to develop a better-defined knowledge base to support local leaders.

A Constitutional False Claims Act, Benjamin Mcmichael, Mackenzi Barrett, W. Kip Viscusi

Articles

The False Claims Act (FCA) represents one of the most important sources, if not the most important source, of liability in the healthcare system and other industries that routinely provide goods and services to the federal government. Originally designed to police fraud during the Civil War, the FCA has become a general statute to enforce many other complex legal schemes. Because failure to comply with complicated statutes and regulations can lead to a reimbursement claim being defined as false under the FCA, the FCA serves as a blunt instrument to cudgel those who fail to comply with the minutiae of …

Unfairness, Reconstructed, Luke Herrine

Articles

A paradigm shift is afoot at major federal consumer protection agencies. For four decades, a bipartisan bloc of bureaucrats has seen the purpose of consumer protection as promoting informed consumer choice or "consumer sovereignty." The idea was that informed consumers in competitive markets would protect themselves by choosing among sellers. Ensuring access to information would then shore up markets' self-correcting tendencies without requiring moral judgment. In the past few years, by contrast, regulators have prioritized sector-wide regulation, enforcement sweeps, and strategic cases against market leaders. They have justified their actions not ( exclusively) in terms of informed choice or efficiency …

Risk Analysis Of Radiosurgery For Vestibular Schwannoma: Systematic Review And Comparative Study Of 10-Year Outcomes, Kevin M. Guy, April A. Pace, Derek S. Tsang, Peter G. Volsky

Department of Otolaryngology (ENT) Faculty Publications

Background: Determine the benefit of stereotactic radiosurgery (SRS) compared to no treatment for sporadic vestibular schwannoma (VS) by calculating epidemiologic risk using 10-year data; apply the analysis to VS that have demonstrated linear growth.

Methods: PubMed, Google Scholar, Web of Science, and Cochrane Library are systematically reviewed for VS tumor control 10 years after SRS and compared to an historical cohort of untreated VS (primary risk analysis). Subgroups of VS limited by size and observed growth are compared to the untreated cohort (secondary analysis).

Results: Twenty-four studies of 4,079 SRS-treated VS exhibited tumor control in 90.93% (87.0%-100%; SD 4.1%), while …

Opioid Usage And Non-Opioid Alternatives In Septorhinoplasty: A Narrative Review, Robert M. Frederick, Eric Dobratz

Department of Otolaryngology (ENT) Faculty Publications

Background and Objective: Opioids are routinely prescribed following septorhinoplasty and oftentimes surgeons prescribe a larger number of tablets than patients require. Considering the high risk of developing opioid dependence and risk of diversion, it is imperative that surgeons practice safer, evidence-based prescribing habits. This review is intended to detail the current state of opioid usage after septorhinoplasty, focusing on articles that show pertinent and practice-altering findings. This will allow surgeons to reflect on their prescribing patterns and make evidence-based decisions to improve them.

Methods: A literature search was performed in November 20, 2024 via PubMed using keywords such as ‘opioid …

Categorizing Clinical Response To Mepolizumab For Patients With Chronic Rhinosinusitis With Nasal Polyps: Synapse Trial, Claire Hopkins, Larry Borish, Jared Silver, Peter Howarth, Robert Chan, Priya Dsilva, Joseph K. Han

Department of Otolaryngology (ENT) Faculty Publications

[Introduction] Chronic rhinosinusitis with nasal polyps (CRSwNP) can substantially affect quality of life (QoL), and is often challenging to manage.¹ First-line treatment for the management of CRSwNP involves intranasal corticosteroids, with short courses of systemic corticosteroids (SCS) for exacerbations, and sinus surgery for uncontrolled disease.² Biologics targeting type 2 inflammation (eg, dupilumab, omalizumab, and mepolizumab) have become a treatment option for refractory CRSwNP. With the advent of disease-modifying treatments such as biologics, control, defined as patients reporting no/low-symptom levels, has increasingly become the treatment goal for CRSwNP.³ However, the optimal use of biologics for symptom control in individual patients remains …

Acute Exacerbations Of Chronic Rhinosinusitis, Robert M. Frederick, Kent Lam, Joseph K. Han

Department of Otolaryngology (ENT) Faculty Publications

Purpose of Review

We aim to highlight recent advancements on the evolving chronic rhinosinusitis (CRS) phenotype: acute exacerbations of chronic rhinosinusitis (AECRS). We focused on studies that expanded the current understanding of its pathophysiology, patient characteristics, and disease burden.

Recent findings

Defining AECRS has been a topic of discussion for many years. A recent regulatory definition of AECRS in the literature incorporates a > 3 day requirement of worsened symptoms and an escalation of treatment. It is important not to rely on patient-reported rescue medication frequency as it was recently demonstrated these are only obtained for 1/3 of reported AECRS episodes. …

A Synthesis Study To Identify And Make Recommendations On The Appropriate Nondestructive Testing Tools For Bridge Beam Ends, Piers, And Abutments, Pan Panjehpour, Prince Baah, Sui Nawl Sang, Emmy Kliewer, Karsten Arnold

JTRP Technical Reports

The aim of this research was to identify suitable NDT methods for bridge components by evaluating their advantages, disadvantages, and limitations. The research objectives are: (1) to identify suitable NDT tools and techniques for condition evaluation of bridge beam-ends, abutments, and piers based on their advantages and disadvantages, (2) to identify gaps in NDT tools and techniques for assessing the condition of concrete bridge members (excluding decks), and (3) to recommend NDT methods for further investigation. The scope of this research was limited to reinforced and prestressed concrete bridge piers, pier caps, beam-ends, and abutments, excluding decks. Research culminated in …

Smartphone Based Non Invasive Real Time White Blood Cell Counter Leveraging Blue Light And Static Magnetic Field, Nafi Us Sabbir Sabith, Masud Rabbani, Kazi Shafiul Alam, Sheikh Iqbal Ahamed

Computer Science Faculty Research and Publications

White blood cells (WBCs), also known as leukocytes, are one of the most significant parts of the immune system. They generate antibodies, protect the body from illnesses, and heal wounds. Accurate estimation of WBCs is key for diagnosing cancer, infections, leukemia, lymphoma, and other diseases. However, the widely used Complete Blood Count (CBC) test presents challenges, including prick anxiety, discomfort, and logistical inconvenience to patients. This study introduces a ubiquous White Blood Cell counting system, UbiWhite, a novel smartphone-based, non-invasive system for real-time WBC counting from fingertip videos. Our system uses optical and magnetic techniques to provide accurate WBC counts …

Causal Discovery On The Effect Of Antipsychotic Drugs On Delirium Patients In The Icu Using Large Observational Ehr Dataset, Riddhiman Adib, Md. Osman Gani, Sheikh Iqbal Ahamed, Mohammad Adibuzzaman

Computer Science Faculty Research and Publications

Delirium occurs in about 80% of cases in the Intensive Care Unit (ICU) and is associated with an extended hospital stay, increased mortality, and other complications. Delirium lacks biomarker-based diagnosis and is frequently treated with antipsychotic drugs (APD), despite numerous studies debating its efficacy. Since randomized controlled trials (RCT) are expensive and time-consuming, we approach the research question of estimating the efficacy and safety outcomes of APD in treating delirium through retrospective cohort analysis. We employed the Causal inference framework to explore the underlying causal model for Delirium patient cohort. We focus on building a structural causal model for delirium …

Voicing The Violence: Carmen Maria Machado's Contribution To A Queer Archive, Audrey C. Bryant

Honors Undergraduate Theses

This project analyzes In the Dream House (2019) alongside “The Husband Stitch” and “Eight Bites” from the collection Her Body and Other Parties (2017) by Carmen Maria Machado. The first, a memoir, details Machado’s personal experience with domestic abuse between partners who share a female gender identity; the latter is a collection of short stories outlining everyday violations made against women. Scholars have discussed these works with specifications including female domestic horror, Machado’s use of retellings, and domestic violence and abuse. This project fills a gap in the discourse by intersecting and connecting queer theory with archival studies to support …

Diving Into Watershed Science And Education: Blending Science, Storytelling, And Professional Practice In Northern Michigan, Mara Clare Pellerito

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio expands understanding of the relationship between watershed education and science through storytelling, lived experiences, and research. In northern Michigan, the invasive Myriophyllum spicatum threatens watershed health by forming dense patches that block sunlight, exclude native plants and wildlife, and retain harmful nutrients later released by herbicide treatment. The Lake Leelanau Lake Association has managed this species with preventative and restorative practices since 2020, and this portfolio examines their results through scientific study and practical experience from the summers of 2024 and 25. It also explores how education serves as a stepping stone from childhood curiosity to a lifetime …

Technol-Ot And Creativity: Implementing Occupational Therapy (Ot) And Assistive Technology (At) Into Art And Music For Adults With Disabilities, Camille Alexandra Aquino, Aarti Subramanian, Austin Yee, Joshua Darrin Montano, Angelica-Kjristen Antonio

Occupational Therapy | MSOT Capstone Projects

Background: Assistive technology (AT) holds the potential to enhance independence and participation among individuals with Intellectual and Developmental Disorders (IDD) and physical disabilities. AT supports for adults with these disabilities remain limited in community settings after they transition out of the K–12 educational system. Addressing this gap requires collaborative, client-centered approaches to implementing effective AT solutions.

Purpose: This project aims to assess and address the AT needs of Marin Ventures (MV), an adult engagement day program, and seeks to develop and implement sustainable AT applications to enhance creative expression and communication for MV clients.

Methods: A needs assessment was conducted …

Exploring The Synergy Of Executive Functions And Sensory Processing In Shaping Occupational Participation, Isabella Aguirre, Kaitlin Mulvaney, Sophia Zertuche

Occupational Therapy | MSOT Capstone Projects

This study adds to the available literature on the relationship between executive functions (EF) and sensory processing (SP), and their combined effect on occupational participation (OP) in children aged 5-12 years. Understanding the nature of this relationship holds the key to identifying factors shaping a child's ability to engage effectively in daily life activities. The research team hypothesized that children with stronger EF and more efficient SP will demonstrate higher levels of OP, while those with challenges in either or both domains may experience limitations to effectively engage in daily activities. Participants consisted of parents of 26 children aged 5 …

Impact Of Sensory Diets On Occupational Performance, Kyndra Holloway, Cassandra Howard, Makena Collin, Princess Pillos

Occupational Therapy | MSOT Capstone Projects

This study investigates the impact of individualized sensory diets on children’s occupational performance in daily life. Sensory diets are structured, child-specific interventions designed to facilitate improved sensory processing by integrating activities into established routines. They involve a tailored home program plan, consistent application, and interventions aligned with the child’s specific sensory needs (Wilbarger, 1995).Using a multiple single-case study design, this research examined the outcomes of sensory diets prescribed alongside direct occupational therapy (OT) services for four white male children aged 3 years, 11 months to 5 years, and 8 months with neurodevelopmental disorders.

Participants were recruited through Developmental FX (DFX) …

Increasing Awareness Of Occupational Therapy For College Students At Dominican University Of California, Joshua James King Ng, Connor Efstathiu, Audrey Nakashima, Rylee Sarasua, Katie Szoboszlay

Occupational Therapy | MSOT Capstone Projects

Background: This project is the third iteration of the Occupational Therapy (OT) college student program at Dominican University of California aiming to promote OT Coaching services for students while enhancing occupational engagement in daily activities, and overall well-being. Occupational therapists play a distinctive role in postsecondary education (AOTA, 2013).The second iteration of the OT college student program (2022–2023) prioritized collaboration with the school’s Student Success Center (SSC) and on-campus Integrative Coaches (ICs) who played a pivotal role in streamlining client referrals and enhancing the program outcomes. During their time with the program, this group was able to flagship a program …

Resilience Programming For Occupational Therapy Students: A Mixed-Methods Exploration, Meghan Shellooe, Jalina Madriaga, Valerie Perez, Gabriela Velazquez

Occupational Therapy | MSOT Capstone Projects

Occupational therapy students and practitioners experience high levels of stress due to classroom and professional demands which can lead to burnout. Resilience is found as a protective factor against stress and burnout. Resilience can be defined as the different ways systems work together to achieve better results than expected, after experiencing adversity. Concepts related to resilience include social connection, self-efficacy, and mindfulness. Research done on resilience programming for students has been shown to support students in navigating the hardships of college. Resilience programming has been found to be effective for occupational therapists in the workplace during high work demands. However, …

Using A Dimension Reduction Approach To Parse Heterogeneity In Dietary Restriction, Amanda Makara

Theses and Dissertations

Dietary restriction, the problematic reduction of caloric or macronutrient intake, is a critical eating behavior occurring transdiagnostically across eating disorders and subclinical disordered eating. The definition of dietary restriction is highly heterogeneous, and restriction is often conflated with other distinct constructs, such as dietary restraint. The current practices related to the definition and measurement of dietary restriction have notable flaws, negatively impacting the ability to identify and establish risk, diagnosis, and treatment of eating disorders. There is also limited evidence that commonly-used dietary restriction measures can validly predict food choice and objective intake. These issues raise questions about whether dietary …

Theatre For The People: Exploring The Need For A New National Theatre, Kai Yamanishi

Theatre and Dance Honors Projects

The Covid-19 pandemic sent shockwaves through the theater industry that have seen dozens of venues across the country laying off workers, shortening seasons, and even closing altogether. Costs have risen, audiences have been slow to return, and traditional sources of funding have dried up. What then, are theaters to do? By conducting an economic analysis and examining published and original interviews with theater practitioners, this essay explores this crisis as it has affected the regional nonprofit theater sector, specifically the members of the League of Resident Theaters (LORT). It concludes that LORT’s model is no longer sustainable because of its …

How South Dakota Can Criminalize Child Sexual Grooming, Jackson Marnette

South Dakota Law Review

In 2023, the South Dakota Legislature proposed and rejected Senate Bill 94, which would have criminalized child sexual grooming. South Dakota, like most states, lacks a law that effectively deters potential child sexual abusers from initiating the child sexual abuse process. Other states’ grooming laws have been challenged on constitutional grounds with differing results. This article considers the benefits of grooming laws, the pros and cons associated with other states’ passed legislation, and any issues with Senate Bill 94’s language. The article concludes with a legislative proposal based on child sexual grooming academic theory.