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An Integrative Review Of Specialised Nursing Career Frameworks To Develop A Nursing Career Framework For Registered Nurses Working In Aged Care, Sachini Thennakoon, Seng Giap Marcus Ang, Victoria Traynor, Karen Strickland Jan 2025

An Integrative Review Of Specialised Nursing Career Frameworks To Develop A Nursing Career Framework For Registered Nurses Working In Aged Care, Sachini Thennakoon, Seng Giap Marcus Ang, Victoria Traynor, Karen Strickland

Research outputs 2022 to 2026

Aim: The aim of this study is to synthesise literature on specialised nursing career frameworks to inform the development of an aged care nursing career framework. Design: An integrative review was conducted. Method: The review followed Whittemore and Knafl's five-step integrative review method. To appraise the quality of the studies, the Quality Appraisal for Diverse Studies tool for peer-reviewed articles and the ACCODS (Authority, Accuracy, Coverage, Objectivity, Date, and Significance) checklist for grey literature were used. Data were extracted and synthesised using the constant comparison method. Data Source: The electronic databases of CINAHL, Medline, PsycINFO and Google Scholar were searched …


Cardiac Monitoring With Textile Capacitive Electrodes In Driving Applications: Characterization Of Signal Quality And Rr Duraction Accuracy, James Elber Duverger, Geordi-Gabriel Renaud Dumoulin, Victor Bellemin, Patricia Forcier, Justine Decaens, Ghyslain Gagnon, Alireza Saidi Jan 2025

Cardiac Monitoring With Textile Capacitive Electrodes In Driving Applications: Characterization Of Signal Quality And Rr Duraction Accuracy, James Elber Duverger, Geordi-Gabriel Renaud Dumoulin, Victor Bellemin, Patricia Forcier, Justine Decaens, Ghyslain Gagnon, Alireza Saidi

Études primaires

Capacitive ECG sensors in automobiles enable unobtrusive heart rate monitoring as an indicator of a driver’s alertness and health. This paper introduces a capacitive sensor with textile electrodes and provides insights into signal quality and RR duration accuracy. Electrodes of various shapes, sizes, and fabrics were integrated at various positions into the seat back of a driving simulator car seat. Seven subjects completed identical driving circuits with their cardiac signals being recorded simultaneously with textile electrodes and reference Ag-AgCl electrodes. Capacitive ECG signals with observable R peaks (after filtering) could be captured with almost all pairs of textile electrodes, independently …


Phase Transformation-Induced Intimate Ag Deposition In Ag-Tio2 Hybrids For Enhanced Photocatalytic Antibacterial Performance, Nhu Nang Vu, Bich Van Tran, Safa Ladhari, Alireza Saidi, Amine Aymen Assadi, Phuong Nguyen-Tri Jan 2025

Phase Transformation-Induced Intimate Ag Deposition In Ag-Tio2 Hybrids For Enhanced Photocatalytic Antibacterial Performance, Nhu Nang Vu, Bich Van Tran, Safa Ladhari, Alireza Saidi, Amine Aymen Assadi, Phuong Nguyen-Tri

Études primaires

The current work presents a novel approach for synthesizing antibacterial Ag-TiO2 hybrid nanoparticles (NPs) by leveraging the phase transformation of dual-phase TiO2 NPs derived from peroxo-titanium complex to promote the Ag photodeposition. The UV-driven Ag deposition initiates transformation from anatase to rutile in the lattice of TiO2 NPs, enhancing their crystallinity while enabling intimate deposition of AgNPs on the TiO2 surface through chemically bonded interfaces. The inherent rutile phase and doped Ag species resulting from the Ag deposition promote the phase transformation as nucleation sites, while the Ag concentration also plays a crucial role in regulating …


Vocational Training And Occupational Health: An Ergonomics Approach To Gender And Disabilities For Social Sustainability, Myriam Bérubé, Céline Chatigny, Marie Laberge Jan 2025

Vocational Training And Occupational Health: An Ergonomics Approach To Gender And Disabilities For Social Sustainability, Myriam Bérubé, Céline Chatigny, Marie Laberge

Études primaires

The Work-Oriented Training Path (WOTP) in Quebec, Canada, is a dual vocational training program that offers students with learning difficulties supervised traineeships. Teachers play a pivotal role in managing students' occupational health and safety (OHS), yet must do so under tight time constraints, limited institutional guidance and highly diverse student profiles. Building on an activity-centered ergonomics and capabilities framework, this multiple-case study explores how gender, disabilities, and work determinants shape OHS management within the WOTP, emphasizing their implications for social sustainability. Twenty-seven semi-structured interviews were conducted with 15 WOTP teachers; 497 narrated anecdotes, which are units of speech when teachers' …


Validation Of A Laboratory Spray Generation System And Its Use In A Comparative Study Of Hexamethylene Diisocyanate (Hdi) Evaluation Methods, Hugues Ahientio, Loïc Wingert, Sébastien Gagné, Livain Breau, Jacques Lesage, Simon Aubin Jan 2025

Validation Of A Laboratory Spray Generation System And Its Use In A Comparative Study Of Hexamethylene Diisocyanate (Hdi) Evaluation Methods, Hugues Ahientio, Loïc Wingert, Sébastien Gagné, Livain Breau, Jacques Lesage, Simon Aubin

Études primaires

Isocyanates are well-known irritants and sensitizers, and measuring their occupational airborne exposure is challenging due to their high chemical reactivity and semi-volatile nature. This study builds on a previous publication by our team that focused on comparing evaluation methods for isocyanates. The current research aims at developing, validating, and applying a laboratory generation system designed to replicate real-world conditions for spraying clear coats in autobody shops using hexamethylene diisocyanate (HDI)-based products. The system involved a spray gun connected to two chambers in series, enabling sample collection and analysis. The system successfully generated HDI and isocyanurate concentrations ranging from 0.008 to …


Organizational And Structural Factors In Building The Therapeutic Alliance In A Work Rehabilitation Program With Injured Immigrant Workers In Quebec, Daniel Côté, Maude Arsenault, Jessica Dubé Jan 2025

Organizational And Structural Factors In Building The Therapeutic Alliance In A Work Rehabilitation Program With Injured Immigrant Workers In Quebec, Daniel Côté, Maude Arsenault, Jessica Dubé

Études primaires

Abstract

The therapeutic alliance is central to occupational rehabilitation, particularly for immigrant workers who face unique challenges of migration and of social and occupational integration. This study explores the development and maintenance of this alliance between immigrant workers with compensated work injuries and their care providers during work rehabilitation. Using ethnography, semi-structured interviews, and focus groups, the qualitative case study involved 7 injured immigrant workers and their interdisciplinary clinical team. The study identified several factors that weakened the alliance, including administrative complexity, conflicting views on pain and disability, cultural stereotypes, and interorganizational communication issues. Many of these challenges were systemic …


Evolution Of Stressors For Healthcare Workers Over The Covid-19 Pandemic, F. Labrèche, Q. Durand-Moreau, A. Adisesh, J.-M. Galarneau, Shannon Ruzycki, Tanis Zadunayski, Nicola Cherry Jan 2025

Evolution Of Stressors For Healthcare Workers Over The Covid-19 Pandemic, F. Labrèche, Q. Durand-Moreau, A. Adisesh, J.-M. Galarneau, Shannon Ruzycki, Tanis Zadunayski, Nicola Cherry

Études primaires

Background:

Many studies have documented exposure to psychosocial factors in healthcare workers (HCWs) during the COVID-19 pandemic. Few have done it prospectively with open-ended questions.

Aims:

To describe the evolution of stress factors reported by HCWs during the pandemic.

Methods:

A prospective cohort of 4964 HCWs (physicians, nurses, healthcare aides, personal support workers), from four Canadian provinces, received four online questionnaires between the springs 2020 and 2022. Responses to an open-ended question on stressful events were coded into 25 stressors. Multilevel logistic regressions assessed trends in stressors, and the effect of gender, occupation, and age.

Results:

In 2020, 91% of …


Heat Camps: Juvenile Curfews, Extreme Heat & The Eighth Amendment, Norrinda Brown Jan 2025

Heat Camps: Juvenile Curfews, Extreme Heat & The Eighth Amendment, Norrinda Brown

Faculty Scholarship

For decades, in the summertime, America has confined certain of its youth in what are essentially open-air heat camps. In city after city, camp-form is established through the enactment of warm-weather juvenile curfews which keep the youth at home or in state-sponsored centers during summer nights and, increasingly, during days as well. Local governments justify these curfews with general notions of “public safety,” including to protect the youth they confine. But the laws are not benevolent. Reducing youth mobility by curfew results in exclusion, oversurveillance, and potentially lethal heat punishment of the youth, possibly in violation of the Eighth Amendment. …


Promoting Angiogenesis/Osteogenesis By A New Copper/Magnesium Hydroxide Hybrid Nanoparticle: In Vitro And In Vivo Investigation, Parsa Khalkhali, Meisam Omidi, Daniela S. Masson-Meyers, Babak Akbari, Mohammad Mehdi Dehghan, Hossein Aminianfar, Saeed Farzad-Mohajeri, Van Mansouri, Lobat Tayebi Jan 2025

Promoting Angiogenesis/Osteogenesis By A New Copper/Magnesium Hydroxide Hybrid Nanoparticle: In Vitro And In Vivo Investigation, Parsa Khalkhali, Meisam Omidi, Daniela S. Masson-Meyers, Babak Akbari, Mohammad Mehdi Dehghan, Hossein Aminianfar, Saeed Farzad-Mohajeri, Van Mansouri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this study, a new hybrid nanoparticle composed of magnesium hydroxide and copper oxide (Mg(OH)2/CuO) with an optimized ratio of magnesium (Mg) to copper (Cu) was designed and incorporated into a 3D-printed scaffold made of polycaprolactone (PCL) and gelatin. These hybrid nanostructures (MCNs) were prepared using a green, solvent-free method. Their topography, surface morphology, and structural properties were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The fabricated 3D-printed PCL/Gelatin/MCN scaffolds were investigated in vitro and in vivo. Cell viability tests on murine calvarial preosteoblasts (MC3T3-E1) and human umbilical vein …


Development Of Adult Multidisciplinary Tracheostomy Rounding Teams: Prevalence, Template For Starting, And Analysis For Diffusion Of Innovation, Tony Satroplus, Teresa Y. Rodriguez, Bennett J. Berning, Sarah Schmoker, Robert Morrison, Jayme Dowdall Jan 2025

Development Of Adult Multidisciplinary Tracheostomy Rounding Teams: Prevalence, Template For Starting, And Analysis For Diffusion Of Innovation, Tony Satroplus, Teresa Y. Rodriguez, Bennett J. Berning, Sarah Schmoker, Robert Morrison, Jayme Dowdall

Posters and Presentations: Otolaryngology

Educational Objective: At the conclusion of this presentation, the participants should be able to (a) Describe the prevalence of adult tracheostomy teams in the Middle Section; (b) Outline the impact of dedicated tracheostomy rounding teams; (c) Craft strategies for multidisciplinary rounding team including the necessary personnel; (d) Identify accelerants and barriers to incorporation of the team at their institution or community. Objectives: Multidisciplinary tracheostomy rounding teams have been found to decrease days to speech and decannulation and decrease adverse events. The need of such teams and the characteristics that increase or inhibit the tracheostomy rounding team's implementation rates have not …


Unlocking The Potential Of Primary Healthcare Nurse Practitioners Globally: A Concept Analysis Of Their Added Value, Isabelle Savard, Gina Sophia Costanzo, Colette Henderson, Deborah C. Gray, Melanie Rogers, Kelley Kilpatrick Jan 2025

Unlocking The Potential Of Primary Healthcare Nurse Practitioners Globally: A Concept Analysis Of Their Added Value, Isabelle Savard, Gina Sophia Costanzo, Colette Henderson, Deborah C. Gray, Melanie Rogers, Kelley Kilpatrick

Ellmer School of Nursing Faculty Publications

Background: Primary healthcare nurse practitioners (PHCNPs) are expanding globally to meet rising healthcare demands. Despite positive outcomes, their added value remains underexplored.

Purpose: To clarify and refine the added value PHCNPs bring.

Methods: Building on a previous concept analysis of the added value of nurse practitioners, we analyzed 37 systematic reviews focusing on PHCNPs’ roles across various settings, using Rodgers’ evolutionary approach.

Findings: Attributes include PHCNPs’ skills and competencies, activities, positive outcomes, and professional autonomy. Antecedents involve PHCNP characteristics and structural and institutional factors, while consequences highlight improved patient outcomes, satisfaction, professional dynamics, and system efficiency.

Discussion: Understanding PHCNPs’ added …


The Role Of Social Isolation In Shaping Health Outcomes In Older Adults: A Regional Analysis, Vince Falco, Lynn Wiles, Jonathan Romero, Leorey Saligan Jan 2025

The Role Of Social Isolation In Shaping Health Outcomes In Older Adults: A Regional Analysis, Vince Falco, Lynn Wiles, Jonathan Romero, Leorey Saligan

Ellmer School of Nursing Faculty Publications

Social isolation is a critical public health concern in older adults and is linked to a range of adverse health outcomes across diverse sociodemographic groups. This study investigated the associations between social isolation with physical and mental health of older adults residing in Hampton Roads, a racially diverse region in Southeastern Virginia, home to a large population of senior military veterans. Secondarily, the study explored how social determinants of health (SDoH) and comorbid medical conditions influenced the relationship of social isolation with physical and mental health of these seniors. Physical and mental health were measured using the Patient-Reported Outcomes Measurement …


The Siren Song Of Territoriality, Robin J. Effron, Alan M. Trammell Jan 2025

The Siren Song Of Territoriality, Robin J. Effron, Alan M. Trammell

Faculty Scholarship

Territoriality—the theory that a state’s physical borders determine its power and sovereignty—boasts a long, venerable history. For centuries, it served as the dominant political theory for myriad ideas. It defined a wide range of doctrines, including personal jurisdiction, choice of law, and prescriptive jurisdiction. By the middle of the twentieth century, though, this rigid territoriality no longer described or responded to the challenges of a society that had grown increasingly mobile and interconnected. Courts replaced inflexible territorial theories with more functional theories rooted in fairness and state regulatory interests.

In recent years, territoriality has seen a curious resurgence. The Supreme …


Cannabinoid-2 Receptor Activation Attenuates Sulfur Mustard Analog 2-Chloroethyl-Ethyl-Sulfide-Induced Acute Lung Injury In Mice, Gregory Nicholson, Nicholas Richards, Janette Lockett, My Boi Ly, Raj V. Nair, Woong-Ki Kim, K. Yaragudri Vinod, Nagaraja Nagre Jan 2025

Cannabinoid-2 Receptor Activation Attenuates Sulfur Mustard Analog 2-Chloroethyl-Ethyl-Sulfide-Induced Acute Lung Injury In Mice, Gregory Nicholson, Nicholas Richards, Janette Lockett, My Boi Ly, Raj V. Nair, Woong-Ki Kim, K. Yaragudri Vinod, Nagaraja Nagre

Department of Biomedical and Translational Sciences Faculty Publications

Background: Exposure to sulfur mustard (SM; 2,2′-dichlorodiethyl sulfide) causes toxicity in the human body, particularly the lungs. The molecular mechanisms of SM-induced lung damage are elusive, and no effective treatments exist. This study explores the anti-inflammatory potential of cannabinoid receptor 2 (CB2R) activation in mitigating acute lung injury (ALI) and inflammation induced by 2-chloroethyl ethyl sulfide (CEES), a structural analog of SM. Methods: C57BL/6J mice were exposed to CEES via intratracheal administration to model ALI. CB2R activation was achieved through the intraperitoneal administration of HU308, a selective synthetic agonist. ALI and inflammation were evaluated at 48 h post-exposure to CEES. …


Neurotensin Regulates Primate Ovulation Via Multiple Neurotensin Receptors, Andrew C. Pearson, Jessica S. Miller, Hannah J. Jensen, Ketan Shrestha, Thomas E. Curry Jr., Diane M. Duffy Jan 2025

Neurotensin Regulates Primate Ovulation Via Multiple Neurotensin Receptors, Andrew C. Pearson, Jessica S. Miller, Hannah J. Jensen, Ketan Shrestha, Thomas E. Curry Jr., Diane M. Duffy

Department of Biomedical and Translational Sciences Faculty Publications

Neurotensin (NTS), a small neuropeptide, was recently established as a key paracrine mediator of ovulation. NTS mRNA is highly expressed by granulosa cells in response to the luteinizing hormone (LH) surge, and multiple NTS receptors are expressed by cells of the ovulatory follicle. To identify the role of NTS receptors NTSR1 and SORT1 in ovulation in vivo, the dominant follicle of cynomolgus macaques (Macaca fascicularis) was injected with either vehicle control, the general NTS receptor antagonist SR142948, the NTSR1-selective antagonist SR48692, or the SORT1-selective antagonist AF38469. Human chorionic gonadotropin (hCG) was then administered to initiate ovulatory events. …


Educational Case: Disseminated Intravascular Coagulation In A Patient With Cancer, Kripa Ahuja, Richard M. Conran Jan 2025

Educational Case: Disseminated Intravascular Coagulation In A Patient With Cancer, Kripa Ahuja, Richard M. Conran

Department of Biomedical and Translational Sciences Faculty Publications

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see https://www.sciencedirect.com/journal/academic-pathology/about/pathology-competencies-for-medical-education-pcme.


Interaction Of Cardiac Leiomodin With The Native Cardiac Thin Filament, Madison Little, Cristina M. Risi, Tania M. Larrinaga, Mason D. Summers, Tyler Nguyen, Garry E. Smith Jr., Jennifer Atherton, Carol C. Gregorio, Alla S. Kostyukova, Vitold E. Galkin Jan 2025

Interaction Of Cardiac Leiomodin With The Native Cardiac Thin Filament, Madison Little, Cristina M. Risi, Tania M. Larrinaga, Mason D. Summers, Tyler Nguyen, Garry E. Smith Jr., Jennifer Atherton, Carol C. Gregorio, Alla S. Kostyukova, Vitold E. Galkin

Department of Biomedical and Translational Sciences Faculty Publications

Every heartbeat depends on cyclical contraction-relaxation produced by the interactions between myosin-containing thick and actin-based thin filaments (TFs) arranged into a crystalline-like lattice in the cardiac sarcomere. Therefore, the maintenance of thin filament length is crucial for myocardium function. The thin filament is comprised of an actin backbone, the regulatory troponin complex and tropomyosin that controls interactions between thick and thin filaments. Thin filament length is controlled by the tropomodulin family of proteins; tropomodulin caps pointed ends of thin filaments, and leiomodin (Lmod) promotes elongation of thin filaments by a “leaky-cap” mechanism. The broader distribution of Lmod on the thin …


Protein Marker-Dependent Drug Discovery Targeting Breast Cancer Stem Cells, Ashley V. Huang, Yali Kong, Kan Wang, Milton L. Brown, David Mu Jan 2025

Protein Marker-Dependent Drug Discovery Targeting Breast Cancer Stem Cells, Ashley V. Huang, Yali Kong, Kan Wang, Milton L. Brown, David Mu

Department of Biomedical and Translational Sciences Faculty Publications

Breast cancer is one of the most common cancers globally. Unfortunately, many patients with breast cancer develop resistance to chemotherapy and tumor recurrence, which is primarily driven by breast cancer stem cells (BCSCs). BCSCs behave like stem cells and can self-renew and differentiate into mature tumor cells, enabling the cancer to regrow and metastasize. Key markers like CD44 and aldehyde dehydrogenase-1 (ALDH1), along with pathways like Wingless-related integration site (Wnt), Notch, and Hedgehog, are critical to regulating this stem-like behavior of BCSCs and, thus, are being investigated as targets for various new therapies. This review summarizes marker-dependent strategies for targeting …


Codon Composition In Human Oocyters Reveals Age-Associated Defects In Mrna Decay, Pavla Brachova, Lane K. Christenson, Nehemiah S. Alvarez Jan 2025

Codon Composition In Human Oocyters Reveals Age-Associated Defects In Mrna Decay, Pavla Brachova, Lane K. Christenson, Nehemiah S. Alvarez

Department of Biomedical and Translational Sciences Faculty Publications

Oocytes from women of advanced reproductive age exhibit diminished developmental potential, but the underlying mechanisms remain incompletely defined. Oocyte maturation depends on translational control of maternal mRNA synthesized during growth. We performed a computational analysis on human oocytes from women < 30 versus ≥40 years and observed that mRNA GC content correlates negatively with half-life in oocytes from young (< 30 yr) but positively with oocytes from aged (>40 yr) women. In young oocytes, longer mRNA half-life is associated with lower protein abundance, whereas in aged oocytes GC content correlates positively with protein abundance. During the GV-to-MII transition, codon composition stratifies stability: codons that support rapid translation (optimal) stabilize mRNA, while slow-translating codons (non-optimal) promote decay. With reproductive aging, GC-containing codons become more optimal and align with increased …


Antibiotic Resistance: The Growing Threats And Potential Solutions, Olisaemeka Zikora Akunne, Blessing Nkechi Emmanuel, Umar Faruk Saidu, Ayobami Sunday Akinnawo, Nasiru Ademola Adeyemi, Livia Chinaza Egoh, Malami Aishatu Muhammad, Olusegun Ayo Ade-Adekunle, Deborah Ahuoyiza Peter, Anne Amina Freitas Jan 2025

Antibiotic Resistance: The Growing Threats And Potential Solutions, Olisaemeka Zikora Akunne, Blessing Nkechi Emmanuel, Umar Faruk Saidu, Ayobami Sunday Akinnawo, Nasiru Ademola Adeyemi, Livia Chinaza Egoh, Malami Aishatu Muhammad, Olusegun Ayo Ade-Adekunle, Deborah Ahuoyiza Peter, Anne Amina Freitas

Department of Biomedical and Translational Sciences Faculty Publications

Antibiotic resistance (AR) has become a critical global health crisis, threatening the efficacy of antibiotics and increasing healthcare costs, morbidity, and mortality. The One Health approach, which emphasizes the interconnectedness of human, animal, and environmental health, is increasingly recognized as an essential framework for addressing the complex drivers of AR. This review explores the mechanisms of resistance, such as genetic mutations, horizontal gene transfer, and biofilm formation, along with contributing factors such as the overuse of antibiotics in healthcare and agriculture. We assess both traditional and emerging strategies to combat AR, including antimicrobial stewardship, the development of new antibiotics, and …


Identifying Notch-Regulated Genes Using A Specific Notch Signaling Inhibitor, Hammed Gafar Jan 2025

Identifying Notch-Regulated Genes Using A Specific Notch Signaling Inhibitor, Hammed Gafar

EWU Masters Thesis Collection

Bone remodeling is a dynamic process that requires a balance between bone resorption by osteoclasts and bone formation by osteoblasts to maintain skeletal integrity. Disruptions to this equilibrium can lead to pathological conditions such as osteoporosis. Osteoclasts originate from macrophages, and their differentiation is regulated by several signaling pathways, notably the notch signaling pathway. Gamma-secretase, an enzyme crucial for initiating notch signaling, can be inhibited by DAPT. However, DAPT also targets non-Notch substrates, complicating the identification of genes specifically regulated by Notch. To address this limitation, this study employed IMR-1A, a selective Notch pathway inhibitor that disrupts the assembly of …


Bridging Prairie Restoration And Regenerative Agriculture With Compost Tea / The Rocket Incident: Post-Fire Soil Microbe Recovery On The Eastern Washington University Restoration Site, April Hersey Jan 2025

Bridging Prairie Restoration And Regenerative Agriculture With Compost Tea / The Rocket Incident: Post-Fire Soil Microbe Recovery On The Eastern Washington University Restoration Site, April Hersey

EWU Masters Thesis Collection

Inland Pacific Northwest prairie is an endangered ecosystem that has been reduced by conversion to agriculture. There is growing interest in the role of soil microorganisms in prairie ecosystems, which may be crucial for restoration of the plant community through interspecies interactions within the rhizosphere. One method for improving soil microorganism community composition is compost tea: enriched liquid compost extract. Compost tea is used in regenerative agriculture to improve crop yields and protect against pathogens. While research has supported compost tea application in regenerative agriculture, it has not been widely studied in the context of ecosystem restoration. After beginning a …


Contract To Kill: Gnas Mutation, Pratima Raut, Poompozhil Mathivanan, Surinder K. Batra, Moorthy P. Ponnusamy Jan 2025

Contract To Kill: Gnas Mutation, Pratima Raut, Poompozhil Mathivanan, Surinder K. Batra, Moorthy P. Ponnusamy

Journal Articles: Biochemistry & Molecular Biology

The mutation in Gsα-coding GNAS exons, popular as gsp oncogene, is the most frequent mutation across all heterotrimeric G proteins involved in oncogenesis. GNAS R201, the most frequently mutated, followed by Q227, are found predominantly across various neoplasms and cancers such as IPMN, pituitary, thyroid, appendiceal, colorectal, etc. This review emphasizes the pivotal significance of the gsp oncogene and its ramifications underpinning the sustained addiction to GNAS mutation. Recent studies delineating the mechanistic intricacies that provide solid evidence of the profound impact of oncogenic GNAS on tumor formation, progression, and maintenance are highlighted. We have leveraged the discoveries of Gsα …


Niclosamide-Loaded Polyanhydride Nanoparticles To Combat Gemcitabine Resistance In Pancreatic Cancer, Brianna M. White, Venugopal Gunda, Susheel Kumar Nethi, Nagabhishek Sirpu Natesh, Adam S. Mullis, Mariaelena Roman Sotelo, Jeffrey North, Chris Destache, Balaji Narasimhan, Surinder K. Batra, Surya K. Mallapragada, Satyanarayan Rachagani Jan 2025

Niclosamide-Loaded Polyanhydride Nanoparticles To Combat Gemcitabine Resistance In Pancreatic Cancer, Brianna M. White, Venugopal Gunda, Susheel Kumar Nethi, Nagabhishek Sirpu Natesh, Adam S. Mullis, Mariaelena Roman Sotelo, Jeffrey North, Chris Destache, Balaji Narasimhan, Surinder K. Batra, Surya K. Mallapragada, Satyanarayan Rachagani

Journal Articles: Biochemistry & Molecular Biology

Purpose

Pancreatic cancer (PC) is a highly lethal malignancy and lacks effective treatments. Current chemotherapies, including gemcitabine (Gem) in combination treatment regimens, produce dose-limiting toxicity, drug resistance, and ultimately limited improvement in the overall survival of PC patients. Niclosamide (Nic), a clinically safe FDA-approved anthelmintic drug has been shown to have anti-cancer properties; however, its limited bioavailability makes Nic largely ineffective as a therapeutic agent. To address this challenge, we have developed a novel combination therapy of Gem with the repurposed drug, Nic, loaded in biodegradable polyanhydride nanoparticles (NicNp), as an effective treatment option for PC.

Methods

We synthesized and …


Psychological Implications Of Preterm Birth, Livio Provenzi, Minesh Khashu, Mia Mclean, Evalotte Morelius Jan 2025

Psychological Implications Of Preterm Birth, Livio Provenzi, Minesh Khashu, Mia Mclean, Evalotte Morelius

Research outputs 2022 to 2026

No abstract provided.


Estimating The Number Of Hospital Beds For The Care Of Sick And Small Newborns: An Evidence-Based Systematic Approach, Bireshwar Sinha, Mohan Kumar, Deena Thomas, Natalie Strobel, Gagan Gupta, Karen Edmond, M. Jeeva Sankar Jan 2025

Estimating The Number Of Hospital Beds For The Care Of Sick And Small Newborns: An Evidence-Based Systematic Approach, Bireshwar Sinha, Mohan Kumar, Deena Thomas, Natalie Strobel, Gagan Gupta, Karen Edmond, M. Jeeva Sankar

Research outputs 2022 to 2026

Background Current recommendations for neonatal bed requirements are largely assumption-based rather than data-driven. We aimed to estimate the number of beds per 1000 live births needed for the care of small and sick newborns. Methods We first extracted data from studies published between 2018 and May 2023. Then, due to considerable heterogeneity in the data, we performed a meta-analysis using a random effects model to estimate the number of neonatal admissions and the length of stay. We divided the total patient days (admission rate multiplied by the length of stay) by 365 to estimate the annual number of beds per …


Improving Mental Health Referral Systems In Rural Australia: Co-Design Study With Health Professionals And Consumers, Kate Bartel, Asini Malinka Siriwardene, Paul Worley, Kim Pearce, Niranjan Bidargaddi, Bronwin Patrickson, Simon Moody, Sharon Wingard, Martin Jones, Brian Mckenny, Darryl Cameron, Sharon Lawn, Amy E. Mendham Jan 2025

Improving Mental Health Referral Systems In Rural Australia: Co-Design Study With Health Professionals And Consumers, Kate Bartel, Asini Malinka Siriwardene, Paul Worley, Kim Pearce, Niranjan Bidargaddi, Bronwin Patrickson, Simon Moody, Sharon Wingard, Martin Jones, Brian Mckenny, Darryl Cameron, Sharon Lawn, Amy E. Mendham

Research outputs 2022 to 2026

Background: In rural Australia, geographical isolation, limited resources, and complex health care navigation create significant barriers to mental health care access. Mental health care professionals and organizations often work in segregation, exacerbating existing barriers. Digital technology provides an opportunity to improve communication between providers and streamline workflows while supporting a diverse range of consumers. Objective: This co-design study aimed to identify rural community needs and explore digital solutions to enhance mental health service delivery pathways. Methods: Using a design-thinking methodology, we conducted focus groups and workshops with 17 participants (7 consumers and caregivers and 10 health care professionals) from a …


Maboo Liyan Boorroo–Good Spirit Country: Using Participatory Research Frameworks To Manage Indigenous Cultural Landscapes In A Time Of Environmental And Political Uncertainty, Martuwarra Riveroflife, Anne Poelina, Martuwarra River Keepers, Sven Ouzman, Tod Jones, Naomi Joy Godden, Martin Brueckner Jan 2025

Maboo Liyan Boorroo–Good Spirit Country: Using Participatory Research Frameworks To Manage Indigenous Cultural Landscapes In A Time Of Environmental And Political Uncertainty, Martuwarra Riveroflife, Anne Poelina, Martuwarra River Keepers, Sven Ouzman, Tod Jones, Naomi Joy Godden, Martin Brueckner

Research outputs 2022 to 2026

Management of cultural landscapes has struggled to understand and adapt to Indigenous ways of managing heritage through a reciprocal duty of care. We argue that barriers to Indigenous cultural landscapes are threefold. First, conceptual barriers exist due to the prevalence of inappropriate heritage concepts and frameworks from the Global North. Second are relational barriers in the form of asymmetrical relationships of power between non-Indigenous heritage ‘experts’ and Indigenous individuals and communities. Third, political barriers present in neo-colonial politics are at odds with the goals of Indigenous movements. After introducing Martuwarra RiverOfLife and her co-authors, we review these barriers within a …


Do Urinary Metabolites Reflect Occupational Exposure To Organophosphate Flame Retardants? A Case Study In Electronic Waste Recycling Workers, Sabrina Gravel, Inna Tata Traore, Miriam Diamond, Liisa Jantunen, Joseph Zayed, France Labrèche, Marc-André Verner Jan 2025

Do Urinary Metabolites Reflect Occupational Exposure To Organophosphate Flame Retardants? A Case Study In Electronic Waste Recycling Workers, Sabrina Gravel, Inna Tata Traore, Miriam Diamond, Liisa Jantunen, Joseph Zayed, France Labrèche, Marc-André Verner

Études primaires

Organophosphate esters (OPEs) are commonly used in electronic devices to meet safety standards, but electronicwaste recycling (e-recycling) workers may face significant exposure to those potentially hazardous compounds in their workplace. We examined the relationship between urinary OPE metabolites and their parent compounds in the air, in Canadian e-recycling facilities. We collected personal air samples and end-of-shift urine samples from workers at six e-recycling facilities. We employed linear and Tobit regression models to assess associations between air concentrations of triphenyl phosphate (TPhP) and three metabolites, of tris (2-chloroethyl) phosphate (TCEP) and two metabolites, of tris (2-chloroisopropyl) phosphate (TCPP) and two metabolites, …


Possibilities For Climate Change Adaptation Investments In Ghana: Exploring Private Sector Concerns And Perceptions About Policy Incentives, Jane Osei, Albert Ahenkan, Samuel Weniga Anuga Jan 2025

Possibilities For Climate Change Adaptation Investments In Ghana: Exploring Private Sector Concerns And Perceptions About Policy Incentives, Jane Osei, Albert Ahenkan, Samuel Weniga Anuga

Research outputs 2022 to 2026

Policy incentives can significantly boost private sector investment in climate change adaptation, especially in developing countries. Leveraging private sector resources, including human capital, financial assets, and technological innovations, is crucial for enhancing adaptation efforts. However, many private entities are reluctant to invest due to the perceived business risks associated with climate change. This hesitancy increases vulnerability in developing nations. This study examines the private sector's views in Ghana on policy incentives for climate adaptation investments and the barriers impeding their involvement. The findings show that corporate social responsibility, financial requirements, and access to relevant information are key motivators for private …