Digital Commons Network^™

Structural Diversity Of Axonemes Across Mammalian Motile Cilia, Miguel Ricardo Leung, Chen Sun, Jianwei Zeng, Jacob R Anderson, Qingwei Niu, Wei Huang, Willem E M Noteborn, Alan Brown, Tzviya Zeev-Ben-Mordehai, Rui Zhang

2020-Current year OA Pubs

Reproduction, development and homeostasis depend on motile cilia, whose rhythmic beating is powered by a microtubule-based molecular machine called the axoneme. Although an atomic model of the axoneme is available for the alga Chlamydomonas reinhardtii

Abdominal Myosteatosis Measured With Computed Tomography Predicts Poor Outcomes In Patients With Glioblastoma, Farzaneh Rahmani, David H Ballard, Tammie L S Benzinger, Sonika Dahiya, John Evans, Sara Hosseinzadeh Kassani, Cyrus A Raji, Marilyn J Siegel, Joseph E Ippolito, Et Al.

2020-Current year OA Pubs

BACKGROUND: Alterations in cellular metabolism affect cancer survival and can manifest in metrics of body composition. We investigated the effects of various body composition metrics on survival in patients with glioblastoma (GBM).

METHODS: We retrospectively analyzed patients who had an abdominal and pelvic computed tomography (CT) scan performed within 1 month of diagnosis of GBM (178 participants, 102 males, 76 females, median age: 62.1 years). Volumetric body composition metrics were derived using automated CT segmentation of adipose tissue, skeletal muscle, and aortic calcification from L1 to L5. Univariable and multivariable Cox proportional hazards models were performed separately in males and …

Slc35a2 Gene Product Modulates Paramyxovirus Fusion Events During Infection, Yanling Yang, Yuchen Wang, Danielle E. Campbell, Heng-Wei Lee, Wandy Beatty, Leran Wang, Megan Baldridge, Carolina B. López

2020-Current year OA Pubs

Paramyxoviruses are significant human and animal pathogens that include mumps virus (MuV), Newcastle disease virus (NDV) and the murine parainfluenza virus Sendai (SeV). Despite their importance, few host factors implicated in paramyxovirus infection are known. Using a recombinant SeV expressing destabilized eGFP (rSeVCdseGFP) in a loss-of-function CRISPR screen, we identified the CMP-sialic acid transporter (CST) gene SLC35A1 and the UDP-galactose transporter (UGT) gene SLC35A2 as essential for paramyxovirus infection. As expected, SLC35A1 knockout (KO) cells showed drastic reduction in infections with SeV, NDV and MuV due to the lack of cell surface sialic acids receptors. However, SLC35A2 KO cells revealed …

Enhancing Engagement In Hiv Care Among Adolescents And Young Adults: A Focus On Phone-Based Navigation And Relationship Building To Address Barriers In Hiv Care, Harriet Fridah Adhiambo, Dorothy Imbuka Mangale, Elvin Geng, Et Al.

2020-Current year OA Pubs

Structural, psychological, and clinical barriers to HIV care engagement among adolescents and young adults living with HIV (AYAH) persist globally despite gains in HIV epidemic control. Phone-based peer navigation may provide critical peer support, increase delivery flexibility, and require fewer resources. Prior studies show that phone-based navigation and automated text messaging interventions improve HIV care engagement, adherence, and retention among AYAH. However, little is known about AYAH experiences utilizing electronic phone-based peer navigation and automated text messaging (E-NAV). We assessed the experiences of AYAH receiving phone-based peer navigation to address barriers to HIV care engagement and viral suppression. We purposefully …

Poor Sleep Is Common In Treatment-Resistant Late-Life Depression And Associated With Poorer Antidepressant Response: Findings From The Optimum Clinical Trial, Michael S B Mak, Marie Anne Gebara, Eric J Lenze, Daniel M Blumberger, Patrick J Brown, Pilar Cristancho, Alastair J Flint, Jordan F Karp, Helen Lavretsky, J Philip Miller, Charles F Reynolds 3rd, Steven P Roose, Benoit H Mulsant, Sarah T Stahl

2020-Current year OA Pubs

BACKGROUND: Adults with treatment-resistant late-life depression (TRLLD) have high rates of sleep problems; however, little is known about the occurrence and change in sleep during pharmacotherapy of TRLLD. This analysis examined: (1) the occurrence of insufficient sleep among adults with TRLLD; (2) how sleep changed during pharmacotherapy; and (3) whether treatment outcomes differed among participants with persistent insufficient sleep, worsened sleep, improved sleep, or persistent sufficient sleep.

METHODS: Secondary analysis of data from 634 participants age 60+ years in the OPTIMUM clinical trial for TRLLD. Sleep was assessed using the sleep item from the Montgomery-Asberg Depression Rating Scale at the …

Molecular Regulation And Therapeutic Targeting Of Vldl Production In Cardiometabolic Disease, Kendall H Burks, Nathan O Stitziel, Nicholas O Davidson

2020-Current year OA Pubs

There exists a complex relationship between steatotic liver disease (SLD) and atherosclerotic cardiovascular disease (CVD). CVD is a leading cause of morbidity and mortality among individuals with SLD, particularly those with metabolic dysfunction-associated SLD (MASLD), a significant proportion of whom also exhibit features of insulin resistance. Recent evidence supports an expanded role of very low-density lipoprotein (VLDL) in the pathogenesis of CVD in patients, both with and without associated metabolic dysfunction. VLDL represents the major vehicle for exporting neutral lipid from hepatocytes, with each particle containing one molecule of apolipoproteinB100 (APOB100). VLDL production becomes dysregulated under conditions characteristic of MASLD …

Reliability Of Wrist Arthroscopy In The Diagnosis And Treatment Of Triangular Fibrocartilage Complex Tears, Elizabeth A Graesser, Lindley B Wall, Sanjeev Kakar, Jeffrey Yao, Marc J Richard, R Glenn Gaston, Charles A Goldfarb

2020-Current year OA Pubs

PURPOSE: Wrist arthroscopy is considered the gold standard for diagnosis of intra-articular wrist conditions including triangular fibrocartilage complex (TFCC) tears; however, the ability to reliably diagnose TFCC pathology during wrist arthroscopy is unclear. The purpose of this study was to assess the reliability of the diagnosis of TFCC tears on wrist arthroscopy videos.

METHODS: Five hand surgeons reviewed 43 cases on a secure web-based platform at two time points separated by 4-6 weeks. Each case included a deidentified clinical vignette and wrist radiographs with ulnar variance measurements and an arthroscopy video of ulnar wrist pathology, averaging 42 seconds. Surgeons were …

Advanced Nanocomposite-Based Electrochemical Sensor For Ultra-Sensitive Dopamine Detection In Physiological Fluids, Megha Shinde, Gymama Slaughter

Center for Bioelectronics Publications

This study presents a novel point-of-care electrochemical sensor for dopamine (DA) detection, featuring a flexible laser-induced graphene (LIG) modified with a unique nanocomposite comprising Nb₄C₃T_x MXene, polypyrrole (PPy), and iron nanoparticles (FeNPs). The LIG-Nb₄C₃T_x MXene-PPy-FeNPs is characterized by scanning electron microscopy to confirm the successful surface modification. The electrochemical performance of the fabricated sensor via cyclic voltammetry showed significant electrochemical activity upon Nb₄C₃T_x MXene-PPy-FeNPs nanocomposite modification of the LIG surface with an increased peak anodic current (Ipa) from 43 μA to 104 μA. The sensor …

Electrochemical Detection Of Prostate Cancer—Associated Mirna-141 Using A Low-Cost Disposable Biosensor, Alexander Hunt, Gymama Slaughter

Center for Bioelectronics Publications

Prostate cancer is the second leading cause of cancer-related deaths among men in the United States. The early detection of aggressive forms is critical. Current diagnostic methods, including PSA testing and biopsies, are invasive and often yield false results. MicroRNA-141 (miRNA-141) has emerged as a promising non-invasive biomarker due to its elevated levels in the urine of patients with metastatic prostate cancer. Here, a low-cost, paper-based electrochemical biosensor for the sensitive detection of miRNA-141 in synthetic urine is reported. The device employs inkjet-printed gold electrodes on photopaper, functionalized with thiolated single-stranded DNA-141 capture probes for specific target recognition. The biosensor …

Gold Nanoparticle-Enhanced Molecularly Imprinted Polymer Electrode For Non-Enzymatic Lactate Sensing, Christopher Animashaun, Abdellatif Ait Lahcen, Gymama Slaughter

Center for Bioelectronics Publications

We are reporting the development of a high-performance, non-enzymatic electrochemical biosensor for selective lactate detection, integrating laser-induced graphene (LIG), gold nanoparticles (AuNPs), and a molecularly imprinted polymer (MIP) synthesized from poly(3,4-ethylenedioxythiophene) (PEDOT). The LIG electrode offers a highly porous, conductive scaffold, while electrodeposited AuNPs enhance catalytic activity and signal amplification. The PEDOT-based MIP layer, electropolymerized via cyclic voltammetry, imparts molecular specificity by creating lactate-specific binding sites. Cyclic voltammetry confirmed successful molecular imprinting and enhanced interfacial electron transfer. The resulting LIG/AuNPs/MIP biosensor demonstrated a wide linear detection range from 0.1 µM to 2500 µM, with a sensitivity of 22.42 µA/log(µM) and …

Electrochemical And Nanomaterial Based Strategies For Nonenzymatic Glucose Detection: A Review, Reagan Aviha, Gymama Slaughter

Center for Bioelectronics Publications

Electrochemical glucose sensing technologies have undergone significant evolution, with continual advancements aimed at improving sensitivity, selectivity, and user convenience. This review systematically explores the development of emerging nonenzymatic glucose sensor designs. Nonenzymatic sensors are critically evaluated for their ability to overcome enzymatic limitations, leveraging novel materials and catalytic mechanisms. Additionally, the emergence of smartphone-integrated glucose monitoring systems is highlighted as the fifth generation, representing a paradigm shift toward personalized, real-time healthcare management. Emphasis is placed on the strategies employed to reduce the working electrode potential and enhance analytical performance. Key analytical metrics and real-sample applicability are evaluated, and persistent challenges …

Molecular Imprinting And Nanomaterial Synergy For Lactate Detection, Christopher Animashaun, Gymama Slaughter

Center for Bioelectronics Publications

Molecularly imprinted polymer (MIP)-based electrochemical sensors have emerged as promising non-enzymatic platforms for the selective and stable detection of clinically and environmentally relevant biomarkers. This review provides a critical, comprehensive analysis of recent advances in MIP-based lactate sensing, with particular emphasis on hybrid systems that integrate conductive nanomaterials including gold and silver nanoparticles, laser-induced graphene, and reduced graphene oxide. These synergistic combinations leverage enhanced surface area, electrical conductivity, and molecular recognition to improve sensor sensitivity, selectivity, and long-term operational stability. Key fabrication strategies, such as electropolymerization, green nanomaterial synthesis, and surface imprinting, are critically examined for their roles in optimizing …

Exploring Automatic And Reflective Nudges For Smishing, Morgan E. Edwards

Psychology Theses & Dissertations

Phishing has been a common problem in the world of cybersecurity for over a decade, leading to significant monetary and privacy losses. Phishing attacks commonly occur via email, but there has been a rise in a new form of phishing known as SMiShing. This attack vector occurs similarly to email phishing, except the malicious message is received via SMS text. While ways to mitigate phishing via email have been widely studied, there is a lack of research on SMiShing and ways to mitigate this problem from a human-centered approach. Interventions such as digital nudges have been successfully applied to …

Barriers To Postpartum Depression Treatment: Availability And Accessibility Of Maternal Behavioral Health-Inclusive Support Groups For Low-Income Populations, Radhika S. Venkatesan

Honors Undergraduate Theses

The maternal health crisis is a prevalent and concerning issue in the United States. The lack of efficient availability and accessibility to health care services plays a significant role in augmenting this problem. One health care service that is often understudied is support groups, for prevalent issues like postpartum depression. Considering the socioeconomic burdens of low-income mothers, this paper analyzed the accessibility and availability of maternal health support groups across counties in Florida, with varying amounts of individuals below the federal poverty level (%BPL). Essentially, Florida counties were divided into one of four categories depending on their %BPL. A Fisher’s …

Prospective Evaluation Of Plasma Proteins In Relation To Surgical Endometriosis Diagnosis In The Nurses’ Health Study Ii, Naoko Sasamoto, Long H. Ngo, Allison F. Vitonis, Simon T. Dillon, Maryam Aziz, Amy Shafrir, Stacey A. Missmer, Towia A. Libermann, Kathryn L Terry

Health Sciences Faculty Publications

No abstract provided.

Clinician Perspectives On Incorporating Physical Activity And Sleep Prescriptions Using Ehealth For Youth With Comorbid Psychiatric Disorders: Qualitative Focus Group Study, Alyssa M. Button, James Slavet, Amanda E. Staiano, April Bowling

Health Sciences Faculty Publications

Background: Physical activity and sleep prescriptions are indicated for the treatment of psychiatric disorders among youth. However, there is limited clinical adoption of these practices. Exergaming (ie, games that require physical activity) is a feasible intervention to promote physical activity and sleep hygiene and is appealing to youth given their interest in video gaming. Integrating exergaming prescriptions into clinical mental health practices may offer an opportunity to expand access to these interventions, yet pragmatic considerations for adopting these programs are poorly understood.

Objective: This study aimed to gain feedback from practicing clinicians on adopting GamerFit, an app-based intervention that incorporates …

Development Of A Bean Cookbook To Assist Families With Low Income Utilize Legumes Provided In Nutrition Assistance Programs, Kira Moneke

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

Introduction: This project aimed to create a cookbook designed to help individuals receiving food assistance through programs like WIC, FDPIR, TEFAP, SNAP, and local food pantries, utilize beans, peas, and legumes in their meals. The focus was on providing easy, accessible recipes using six different types of beans to improve diet quality.
Methods: The cookbook was developed considering limited cooking skills, equipment, literacy, and time that may be barriers to preparing healthy food for low-income adults. Selected recipes were compiled into an educational cookbook.
Results: Recipes were tested and developed for six types of beans and aquafaba. …

Assessing The Prevalence Of Food Security Among South Dakotan Families Who Have Children With Disabilities, Erica Declark

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

Background
Almost 13% of U.S. families experienced food insecurity in 2022; i.e., an inability to acquire enough food to meet household members’ needs. Many factors can influence food security status, such as environmental conditions, social factors, and financial costs. Families with children who have disabilities may be at higher risk for food insecurity due to additional financial stressors related to these children’s care.
Purpose
The purpose of this study was to determine the prevalence of food insecurity among South Dakota families who have children with disabilities. We hypothesized that South Dakota families with children with disabilities are at an increased …

Out-Of-Pocket Healthcare Expenses Are Associated With Food Insecurity Among South Dakotan Families Who Have Children With Disabilities, Halie E. Kruid

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

Background
In 2023, 17.9 percent (6.5 million) of households with children experienced household food insecurity, i.e., an inability to acquire enough food to meet household members’ needs. Many socioeconomic factors can influence food security status, such as environmental conditions, social factors, and financial costs. Families with children with disabilities (CWD) may be at higher risk for food insecurity due to additional financial stressors related to these children’s care.
Purpose
The purpose of this study was to determine the prevalence of food insecurity, as well as the medical and financial factors associated with an increased food insecurity prevalence, among South Dakota …

Healthaide: Developing An Audit Framework For Ai-Generated Online Health Information, Tahir Hameed

Management Faculty Publications

No abstract provided.

Benefits Of Early Intervention With A Certified Lymphedema Therapist For Management Of Radiation Fibrosis Syndrome (Rfs) And Axillary Web Syndrome (Aws) In Breast Cancer Patients, June Leary, June Leary

Capstone Showcase

All breast cancer treatment leads to soft tissue changes in the treated quadrant. While these changes are chronic, they are also identifiable and manageable with care from an appropriate provider. Scarring, lymphedema, radiation fibrosis syndrome (RFS), and axillary web syndrome (AWS) may all be part of the post-treatment soft tissue changes for a breast cancer survivor.

Familiarity with the likely presentation and lifelong management of a patient’s specific symptom burden is crucial. While any physical therapist can rehabilitate the neuropathies, shoulder pain, postural dysfunction, or other numerous orthopedic issues that may occur, there is an acknowledged deficit in the treatment …

Myrtillin As A Promising Immunomodulator: Molecular Modeling And Pharmacokinetic Evaluation, Adolat Manakbayeva, Timur Kerimov, I D. Ershov, E. I. Anarkulova, Pavel Alexyuk, Y Moldakhanov, Ahdrey P. Bogoyavlenskiy, Vyacheslav Dushenkov

Publications and Research

Myrtillin, an anthocyanin found in blueberry fruits, is known for its antioxidant and potentially immunomodulatory properties. In this study, molecular docking was used to evaluate its interactions with a wide panel of immune-related proteins, including pro-inflammatory cytokines (TNF-α, IL-6, IL-17), antiinflammatory mediators (IL-4, IL-10), and signaling pathway proteins (1NFK, p52/RelB). The in silico results were supported by interaction analysis, and an ADMET analysis was conducted to assess the pharmacokinetic and toxicological profile. The findings confirm the promise of Myrtillin as a natural modulator of inflammatory responses.

Fp-25-18 Recent Marriages To Same-Sex And Different-Sex Couples: Marital History And Age At Marriage, 2023, Christopher A. Julian, Krista K. Westrick-Payne, Wendy D. Manning

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-25-26 Thirty-Five Years Of Changing Cohabitation Experience In The U.S., 1987-2022, Wendy D. Manning, Krista K. Westrick-Payne

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-25-28 Distributions Of Age At First Birth, 1960-2023, Christopher A. Julian, Wendy D. Manning

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-25-30 Refined Marriage Rate In The U.S.: Geographic Variation, 2024, Krista K. Westrick-Payne

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-25-31 Refined Divorce Rate In The U.S.: Geographic Variation, 2024, Krista K. Westrick-Payne

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-25-32 Marriage-Divorce Ratio In The U.S.: Geographic Variation, 2024, Krista K. Westrick-Payne

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-25-33 Number Of Children Living In Households Headed By Same-Sex And Different-Sex Couples, 2023, Christopher A. Julian, Krista K. Westrick-Payne, Wendy D. Manning

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Fp-25-34 Older Parents’ Expectations Of Care From Children By Parents’ Nativity Status, Race, And Educational Attainment, Elisa Hernandez, Jaycob Applegate, Jenjira Yahirun

National Center for Family and Marriage Research Family Profiles

No abstract provided.