Digital Commons Network^™

Unveiling Trauma And Seeking Justice: Exploring Mass Atrocities Against Tamils Through The Lens Of Religion, Culture, And Global Justice, Arrabe Vigneswaran

Theses and Dissertations (Comprehensive)

This paper examines the mass atrocities committed against the Tamil population in Sri Lanka, analyzing them through the interconnected lenses of religion, culture, and global justice. It explores how Sinhalese-Buddhist nationalism, codified through legal and constitutional mechanisms such as the Sinhala Only Act and state-sponsored cultural erasure, facilitated the systemic marginalization, displacement, and dehumanization of Tamils. The study investigates the legal, political, and cultural underpinnings of these acts ranging from war crimes and ethnic cleansing to potential genocide while assessing the reluctance of both domestic and international actors to enforce meaningful accountability. Drawing on hybrid court models, transitional justice theories, …

Examining Gender Differences In Heritage Language Maintenance And Loss Among South Asian First-Generation Canadians, And The Effect On Well-Being, Amreen Sangha

Theses and Dissertations (Comprehensive)

Language is prevalent in various aspects of life. Not only is it often essential for communication, but it also has deep roots within cultural contexts. Specifically, within South Asian culture knowing one’s heritage language is considered to be necessary when it comes to connecting with one's cultural group and identity. Heritage language maintenance can be seen differently within different individuals and have different implications for them. This study was designed to explore gender differences in heritage language loss as well as the role language may play in one’s well-being. Canadian-born South Asian children and young adults aged 10-25 completed an …

“We’Re Here, We’Re Queer, And We’Re Not Going Away” Student Policies And Lgbtq+ Students’ Experiences On Canadian Christian Campuses, Angela E. Gallo

Theses and Dissertations (Comprehensive)

Research highlights that Christian campuses are often unwelcoming and hostile spaces for lesbian, gay, bisexual, transgender, queer, and other gender and sexually diverse (LGBTQ+) students. Yet, research, including emerging Canadian research, often overlooks how institutional policies shape LGBTQ+ students’ experiences. Further, little attention is given to the affirming experiences LGBTQ+ students encounter on Christian campuses. Through a collective case study of two Canadian Christian universities involving document analysis and interviews, I explored the discourses that school policies constructed concerning gender and sexuality, LGBTQ+ students’ experiences of exclusion and affirmation, and how policy, alongside other factors, shapes their experiences and well-being. …

Development Of A Stress Response Framework For Understanding Sogie Refugee Health, Arooran Saravanan Ananthavel Murugan

Theses and Dissertations (Comprehensive)

As an increasing number of individuals flee persecution on the basis of sexual orientation and gender identity expression (SOGIE), Canada has become a prominent destination for SOGIE refugees. The chronic stressors encountered by this marginalized population remain insufficiently studied, particularly in relation to physical health outcomes. This qualitative study investigates the cumulative health impacts of chronic stress among SOGIE refugees through the application of a cell-to-society framework, underpinned by Minority Stress Theory (MST). The study seeks to develop a SOGIE-specific stress response framework that theorizes the processes by which social and environmental stressors become biologically embedded, thereby contributing to elevated …

Negotiated Cultural Identity And Belonging Of Self-Identified Indo-Guyanese Immigrant Women, Neta (Goomatee) Deonarain-Gear

Theses and Dissertations (Comprehensive)

This dissertation examines how young, self-identified Indo-Guyanese women who immigrated to Southwestern Ontario in the 1970s negotiate cultural identity and belonging. Utilizing a bio-ethnographic bricolage narrative methodology, the study explores the impact of postcolonial diaspora and social displacement on these women’s experiences within the "third space" or borderlands. Grounded in relativist ontology and constructivist epistemology, storytelling serves as the primary data collection method through a critical theory lens. Interviews with 12 participants were analyzed thematically and reflexively, revealing how participants construct meaning and navigate cultural identities. The analysis, conducted through feminist, decolonial, and trauma-informed perspectives, offers insights into "psychological homelessness" …

Neighbourhood Resilience Planning With Renters In Hamilton, Ontario, Canada, Anna Do

Theses and Dissertations (Comprehensive)

This sequential mixed-methods study demonstrates the co-production of knowledge between academic researchers and local communities. Guided by the resilience planning framework, the study engaged 48 renters from the Beasley neighbourhood of Hamilton, Ontario, Canada in identifying stressful and supportive locations using a participatory mapping tool called the “Place Report.” A total of 74 Place Reports were submitted, with most reporting supportive places in or near Beasley. Thematic analysis revealed three overarching domains, and 13 themes related to the use and function of these locations. Places pertaining to food, housing, and physical activity emerged as the most frequently discussed topics. The …

Legislating Trans Lives: An Archival Analysis On Trans Canadian Rights, Charlie E. C. Davis

Theses and Dissertations (Comprehensive)

Previous research has outlined trans histories within the United States and Europe, illustrating historic transphobia, oppression and the origins of gender identity clinics. This type of historical literature is limited in the Canadian context, with more contemporary research demonstrating that trans people experience significant barriers to accessing healthcare, aversive health outcomes, and high rates of discrimination. Trans activists and advocates have always been and continue to resist these oppressive systems and have worked to improve the social and physical wellbeing of trans people in Canada. Utilizing archival data of trans activism and community mobilizing, I sought to address the gap …

Exploring Laurier Health Sciences Students’ Knowledge Of Lgbtq+ Health, Grace Emma Henry, Todd Coleman

Theses and Dissertations (Comprehensive)

In all health-related fields, the need for well-informed, holistic healthcare providers is paramount. For the heathcare field to be impactful in positive ways, providers should emerge from multifaceted academic backgrounds, equipped with an array of knowledge and skills to address the complex needs of different patients. Central to this is the idea that all aspects of an individual's identity and the intersectionality of these identities should be considered when providing care. Intersectionality recognizes that various social and personal identities, such as race, gender, sexuality, and socioeconomic status, intersect to shape individual experiences and health outcomes (Kelly et al., 2022).

Lesbian, …

More Than Meets The Eye: A Phenomenological Study Of Self-Concept, Identity, And Meaning-Making In Adults With Acquired Vision Loss, Melinda M. Szilva

Theses and Dissertations (Comprehensive)

The qualitative research project examines the lived experience of acquired vision loss in adulthood and its impact on the way participants see themselves and the world around them, both sensorially and metaphorically. The research question, “What are the lived experiences of adults with acquired vision loss as they relate to identity and conceptions of self?” is informed by the researcher’s clinical practice as a psychotherapist in a low vision clinic. The dissertation includes a literature review focussed on the psychosocial aspects of vision loss to provide insight into the intended population and context for the study. Data for the phenomenological …

Immune Pathway Modulation In Melanoma Using Chitosan Nanoparticle-Mediated Dsrna Delivery, Bethel C. Iwuji

Theses and Dissertations (Comprehensive)

Cancer is a group of diseases characterized by abnormal and uncontrolled cell division, which typically results in the formation of tumours. Even with advances in treatments, cancer remains one of the leading causes of death globally. Melanoma is an aggressive form of skin cancer which is highly malignant, develops in the pigment-producing cells of the skin, melanocytes, and in the late stages of the disease poses a significant challenge for therapeutic intervention due to its multidrug resistance. The innate immune system is the first line of defence against invading pathogens, including viruses, bacteria, and fungi, and can recognize and destroy …

Comprehensive Analysis Of Environmental Particulate Matter: Chemical Composition And Microbial Assessment, Uyen T. L. Le

Theses and Dissertations (Comprehensive)

Rapid industrialization and population growth have contributed to a decline in air quality, with particulate matter (PM) posing particular concern. PM originates from both natural and human sources and often contains toxic chemicals and microorganisms, including potential pathogens. Inhalation of PM is linked to respiratory and cardiovascular diseases, underscoring the need to characterize better its chemical and biological composition in understudied region - Waterloo, Ontario, Canada. The present thesis is a culmination of three main parts. Part 1 will describe the use of the dithiothreitol (DTT) assay to quantify the oxidative potential of PM through DTT consumption of redox-active field …

A Dance Of War Or Love: Applying A Gendered Lens On The Lived Experiences Of Women Social Entrepreneurs In Nigeria, Grace C. Ihejiamaizu

Theses and Dissertations (Comprehensive)

This study explores the lived experiences of Nigerian women social entrepreneurs, using a qualitative methodology rooted in yarning circles, a culturally respectful, relational approach that foregrounds storytelling and co-construction of knowledge. Through this method, the research examines how these women navigate the intersections of gender, culture, power, and purpose within highly patriarchal and institutionally constrained environments.

The findings assert that Nigerian women social entrepreneurs are not static actors driven by fixed motivations, but dynamic changemakers whose goals shift as they gain access to resources, legitimacy, and social capital. The Cycle of Privilege framework helps us understand this evolution as an …

Terpenes Mitigate Thc-Induced Working Memory Deficits: Behavioural Evidence Of The Entourage Effect Using A 2-Component Operant Memory Task, Lara Mitchell

Theses and Dissertations (Comprehensive)

Most research on cannabis and cognitive function has focused on delta-9-tetrahydrocannabinol (THC). However, this approach overlooks the complex chemical composition of cannabis products consumed by the public, which often includes cannabidiol (CBD) and various terpenes. These additional constituents may interact with THC to modulate its effects, a phenomenon known as the entourage effect. While this theory has gained traction, experimental evidence for the cognitive impact of terpenes in combination with THC remains limited. This study aimed to assess whether terpenes can mitigate THC-induced cognitive deficits using a 2-Component Operant Memory task. Male Sprague-Dawley rats received intraperitoneal injections of either …

Exploring The Role Of Collective Narcissism And Ideology In Support For Reparations, Melih Can Sahin

Theses and Dissertations (Comprehensive)

Many societies with colonial histories have begun to grapple with their legacy of historical injustices and their ongoing consequences, leading to national apologies and sometimes consideration of reparations. In this context, it is important to understand the factors enhancing or impeding public support for reparations. This dissertation focused on the role of beliefs (ideology) and identity (collective narcissism) as predictors of support for reparations addressing historical injustices. Drawing from existing research, we expected that those higher in conservatism – and those higher in collective narcissism - would oppose reparations more strongly. We also examined the interaction between ideology and collective …

Integrating Indigenous Values And Community Strengths To Achieve Indigenous Food Sovereignty And Community Well-Being In The Ka’A’Gee Tu First Nation, Northwest Territories, Jennifer K. Temmer

Theses and Dissertations (Comprehensive)

Northern Indigenous communities face disproportionate impacts from interconnected challenges related to climate change, food security, health, and cultural preservation, that threaten traditional food systems and practices. While there is a growing recognition of the importance of community-driven solutions, existing frameworks fail to integrate Indigenous values and local priorities effectively. This research addresses this gap by exploring how the Ka’a’gee Tu First Nation (KTFN) is responding to these crises through climate change adaptation efforts focused on food system sustainability as a pathway to self-sufficiency and community well-being. To contribute to these efforts, this dissertation uses Participatory Action Research to facilitate community-driven …

The Body’S “Why?”: Therapists’ Embodied Approaches To Meaning-Making In Trauma And Complex Ptsd, Tanya D. Rock

Theses and Dissertations (Comprehensive)

The challenge of finding meaning in trauma is one that has inspired conversations in psychotherapeutic circles as well as amongst theologians and philosophers. Finding meaning following trauma has been positively associated with growth following the traumatic incident and has been labelled as critical to the progression of healing (Herman, 1992). This study aims to examine the role therapists play in meaning-making with clients who have experienced trauma. The research question is “how do therapists handle meaning of life challenges with traumatized clients?” Ten experienced therapists participated in this qualitative, phenomenological study. Key findings included common therapist responses to client’s “why?” …

Feeling Blue: The Effects Of Blue Light Exposure On Reproduction And Physiology In Drosophila Melanogaster, Laura Hampel

Theses and Dissertations (Comprehensive)

Blue light, the wavelengths ranging from ~400-500 nm, is emitted from the sun and more recently, by artificial lights including those in technology. In humans, prolonged exposure to blue light has been consistently linked to circadian rhythm disruption and retinal damage, and has also been associated with changes in neurodegeneration, aging, mortality, and oxidative stress in model organisms. This thesis explores the multifaceted effects of blue light exposure through two independent but complementary approaches. An initial rapid review of the current state of knowledge on blue light induced oxidative stress in humans was conducted. This revealed that the most studied …

“Just Checking”: Racial Profiling And The Criminalization Of Black Students At Post-Secondary Institutions, Yugita Looknauth

Theses and Dissertations (Comprehensive)

“Just Checking”: Racial Profiling and the Criminalization of Black Students at Post-Secondary Institutions

This dissertation examined the experiences of Black students who came into contact with campus security at five universities and one college in Ontario, Canada. Critical race theory and methodology, and qualitative research design amplified the voices of 17 participants who shared stories of racial profiling marked by racialization, criminalization, surveillance, and the normalized scrutiny of Black life. These experiences are legitimized by post-secondary institutions that are actively reproducing the very racism they are often celebrated for interrogating by allowing a culture of anti-Black racism to exist with …

Microbial Degradation Of Persistent Organic Pollutants In Food Supply Chain, Pankaj Kumar, Ajay Singh, Manikant Tripathi, Deepti Diwan, R Manimekalai, Minaxi Sharma, Sudisha Jogajah, Ramesh Chandra Dubey, Gauri Dutt Sharma

2020-Current year OA Pubs

No abstract provided.

Effects Of Obesity On Plasma Biomarker And Amyloid Pet Trajectories In Alzheimer's Disease, Soheil Mohammadi, Farzaneh Rahmani, Mahsa Dolatshahi, Suzanne E Schindler, Cyrus A Raji, Adni Collaborators

2020-Current year OA Pubs

INTRODUCTION: Obesity is a risk factor for Alzheimer's disease (AD), but its impact on AD blood biomarker (BBM) and amyloid positron emission tomography (PET) trajectories is unknown.

METHODS: One thousand two hundred twenty-eight plasma samples from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were assessed using six leading commercial tests (C2N, Fujirebio, Janssen, ALZpath, Roche, and Quanterix). Amyloid PET scans were used to assess amyloid burden in Centiloids (CLs). Spearman partial correlations assessed cross-sectional associations, while linear mixed-effects models examined the longitudinal impact of obesity status on BBMs and CLs.

RESULTS: Higher body mass index at baseline was correlated with lower …

System Readiness And The Patient Care Pathway For Alzheimer's Disease Diagnosis And Treatment, B Joy Snider, Et Al.

2020-Current year OA Pubs

Promising therapeutic interventions that target the underlying pathophysiology are changing the landscape of Alzheimer's disease (AD) research. The AD care pathway must be transformed to meet the challenge of bringing these new therapies to the increasing number of people living with AD within the existing healthcare framework. Challenges include identifying patients who may benefit from treatment interventions early in the course of the disease, ensuring that diagnostic tools are accessible and accurate, and developing capabilities to monitor the effectiveness of interventions over time. These challenges must be addressed at all levels, from primary care settings to tertiary treatment centers; this …

Clinical And Neuropathological Associations Of Plasma Aβ42/Aβ40, P-Tau217 And Neurofilament Light In Sporadic Frontotemporal Dementia Spectrum Disorders, Binita Rajbanshi, Randall J Bateman, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Plasma amyloid beta

METHODS: We compared the clinical, neuroimaging, and neuropathological associations of plasma Aβ

RESULTS: Aβ

DISCUSSION: Plasma p-tau217 has clinical, neuroimaging, and neuropathological correlates in sporadic FTD and may identify FTD cases with AD co-pathology.

HIGHLIGHTS: Alzheimer's disease (AD) features could be identified with plasma phosphorylated tau217 (p-tau217) in frontotemporal lobar degeneration (FTLD).Plasma p-tau217 is a better discriminator of AD co-pathology and AD-associated features in FTLD than plasma amyloid beta

Qualitative And Quantitative Analysis Of A Novel Dental Health Education Program To Improve Dental Care Utilization By Bhutanese-, Burmese-, And Swahili-Speaking Refugees In A Midwestern United States City, Chandra Swanson, Katherine Gordon, Kelly Kreisler, Elizabeth Montgomery Collins

2020-Current year OA Pubs

No abstract provided.

Enhancing Safety: Multi-Institutional Fmea And Fta On 177 Lu-Based Radio-Pharmaceutical Therapy, Siju C George, Santiago Aguirre, Nichole M Maughan, Ranjini Tolakanahalli, E James Jebaseelan Samuel, Sven L Gallo, Jacqueline E Zoberi, Yongsook C Lee

2020-Current year OA Pubs

PURPOSE: This study investigates potential failure modes and conducts failure mode and effects analysis (FMEA) and fault tree analysis (FTA) on the administration of

METHODS: We reviewed the literature to investigate the administration of Pluvicto and Lutathera, focusing on prospective procedural failures and potential failure modes (PFMs) and their outcomes. We distributed an FMEA survey to multiple experienced centers in

RESULTS: The findings from the literature review and survey responses on the prospective study have identified several critical areas at risk of failure. These areas include non-optimized treatment delivery, inadequate patient monitoring, and lack of safety training, leading to radiation …

Iliac Crest Bone Block Autograft Transfer For Ballistic Posterior Glenoid Fracture: A Case Report, Jordan Cook Serotte, Hayden Baker, Cody Lee, Jason A Strelzow

2020-Current year OA Pubs

No abstract provided.

Depression And Weight Loss Trajectories During An Integrated Behavioral Intervention: Within-Treatment Analysis Of The Rainbow Trial, Bailey W. Osweiler, Daphne Lew, Nan Lv, Jun Ma, Thomas G. Kannampallil

2020-Current year OA Pubs

INTRODUCTION: Depression and obesity are two of the most common chronic conditions among US adults. The Research Aimed at Improving Both Mood and Weight (RAINBOW) study was the first randomized clinical trial to demonstrate the effectiveness of an integrated behavioral treatment for depression and obesity. We aimed to characterize the trajectories of both depression symptoms and weight loss during the RAINBOW intervention.

METHODS: Participants (N = 201) randomly assigned to the RAINBOW treatment arm who provided serial data on depression symptoms (via the 9-item Patient Health Questionnaire [PHQ9]) and self-measured weight were included. Group-Based Multi-Trajectory Modeling is a statistical technique …

Vagus Nerve Stimulation In Treatment-Resistant Depression: A One-Year, Randomized, Sham-Controlled Trial, Charles R Conway, Christopher L Kriedt, Et Al.

2020-Current year OA Pubs

BACKGROUND: Few treatments are available for individuals with marked treatment-resistant depression (TRD).

OBJECTIVE: Evaluate the safety and effectiveness of FDA-approved adjunctive vagus nerve stimulation (VNS) in patients with marked TRD.

METHODS: This 12-month, multicenter, double-blind, sham-controlled trial included 493 adults with marked treatment-resistant major depression who were randomized to active or no-stimulation sham VNS for 12 months. The primary outcome was percent time in response across months 3-12, with response defined as a ≥50 % change from baseline on the Montgomery-Åsberg Depression Rating Scale (MADRS). Several secondary endpoints were evaluated.

RESULTS: Overall, 88.4 % of participants completed the trial. Percent …

Improving Training On Hepatitis B Research In Nigeria: Findings From An Innovation Bootcamp To Strengthen Capacity, Maria A. Afadapa, Olufunto A. Olusanya, Peter Kalulu, Nkiruka Obodoechina, Temitope Ojo, Juliet Iwelunmor, Et Al.

2020-Current year OA Pubs

We organized an Innovation Bootcamp for young people in Nigeria to develop strategies promoting the uptake of the hepatitis B birth dose vaccine among newborns, which remains low, with an estimated coverage of 52%. This event was a collaborative, cross-disciplinary capacity-building platform to generate creative solutions addressing barriers to Hepatitis B vaccine uptake. The purpose of this study was to describe the bootcamp activities that address this gap and evaluate the impact of an Innovation Bootcamp designed to build research capacity among young Nigerians. The bootcamp was informed by Participatory Action Research focused at engaging young people as co-researchers to …

Exploring Factors Contributing To Patient Decision-Making In The Care Journey To Elective Hernia Care In Kenya, Helen W. Li, Jesse Kiprono Too, Sarah Nyanchama Nyariki, Charles Nathan Nessle, Sara Malone, Rachel Matsumoto, Teddy Ashibende Aurah, Jeffrey A. Blatnik, Joanna Hunter-Squires, Ivan Seno Saruni

2020-Current year OA Pubs

BACKGROUND: Capacity for elective general surgical care is an important reflection of a health system's ability to meet a population's surgical needs and is currently known to be inadequate in many low- and middle-income countries. Patient agency is a key, understudied factor which shapes how and when patients ultimately decide to engage with formal care. Understanding factors which influence patient care seeking activity can have important implications for how current and future health systems may be utilized. This study aims to explore how patients approach the navigation and triage of their elective hernia condition within the Kenyan surgical care system. …

Diagnosis And Management Of Gastroesophageal Reflux Disease: Current Insights, Abhinav Vayal-Veettil, C Prakash Gyawali

2020-Current year OA Pubs

Gastroesophageal reflux disease (GERD) results from retrograde movement of gastric content into the esophagus and beyond, resulting in symptoms, mucosal injury and long-term complications. Typical symptoms of heartburn and regurgitation are highly suggestive of GERD, but atypical presentations require careful evaluation to rule out alternative diagnoses. Diagnostic modalities, including endoscopy, ambulatory reflux monitoring, and high-resolution manometry, play a pivotal role in confirming GERD and guiding personalized treatment. Management strategies consist of lifestyle modifications, pharmacologic therapy with anti-secretory agents, and adjunctive treatments such as alginates and baclofen. For refractory cases, surgical and endoscopic interventions offer durable symptom relief. Complications of GERD …