Digital Commons Network^™

Recombinant Factor Viia: New Insights Into The Mechanism Of Action Through Product Innovation, Miguel A Escobar, Maureane Hoffman, Giancarlo Castaman, Cedric Hermans, Johnny Mahlangu, Johannes Oldenburg, Charles L Percy, Mark T Reding, Amy D Shapiro, Steven W Pipe

Faculty, Staff and Student Publications

Management of bleeding in persons with hemophilia and inhibitors involves treatment with bypassing agents, including recombinant activated factor VII (rFVIIa). Two rFVIIa products are commercially approved for use in the United States and the European Union. Eptacog alfa and eptacog beta share the same amino acid sequence but differ in posttranslational modifications. Although rFVIIa has been used to manage bleeding in persons with hemophilia and inhibitors for over 30 years, its mechanisms of action is still being studied. In vitro and in vivo studies have suggested that rFVIIa could promote hemostasis by (1) increasing tissue factor-dependent activation of factor (F)X …

Wmu Board Of Trustees Formal Session February 5, 2025, Wmu Board Of Trustees

WMU Board of Trustees Meetings

Acceptance of the Agenda

Approval of the Minutes (December 12, 2024 Meeting)

Remarks by the Vice Chair of the Board

Remarks by the President

Updates by the Faculty Senate President

Updates by the Western Student Association President

Updates by the Graduate Student Association President

Employee Graduates

Climb Onward – A Look-in on WMU Athletics’ Strategic Plan

Public Comments Regarding Action Items

Action Items

Western Michigan University Board of Trustees Annual Officer Election

Delegated Board of Trustees Authority to Confer Degrees

Faculty Senate Constitution Amendments

Campus Master Plan 2025 and Beyond

2025 General Revenue Bonds

Consent Item

• Personnel Report
• Curriculum Proposals …

Irene Blyden Taylor: God’S Apostle To Nevis, Robert A. Danielson

The Asbury Journal

Irene Blyden Taylor was an early Holiness convert from the Island of Saba in the West Indies. Her life intersects a number of key people and places in the history of the Holiness Movement, as she worked with C.O. Moulton, one of the founding Holiness missionaries in the Caribbean, attended school at God’s Bible School and College, and as she worked as an evangelist and church planter on the Islands of St. Kitts, Nevis, and Saba. Through her story, the origins of Holiness mission work in the English speaking Caribbean can be explored as well as key missiological insights. Blyden …

Ai And Higher Education, Chris A. Kiesling

The Asbury Journal

No abstract provided.

Freemasonry And The Methodist Episcopal Church In The Nineteenth Century, Nicholas M. Railton

The Asbury Journal

Virtually nothing has been written on the presence and impact of Freemasonry within the Methodist Episcopal Church. This article begins to fill this lacuna by shedding some light on the topic. It has been claimed that John Wesley was himself a Freemason. In his journal he briefly discusses a book by an ex-Mason.

In this article some of the similarities and differences between the two systems are highlighted. The Morgan Affair temporarily weakened the position of Freemasonry in the Methodist Episcopal Church and in broader American society. Twelve short biographies of Methodists who joined the lodge show that the influence …

Analyzing Real-Time Behavioral Shifts In Response To Tourism Policy Using Google Trends Data And Advanced Difference-In-Differences (Did) Methods, Aaron Bradley Scott

Doctor of Business Administration Dissertations

Google Trends is a publicly available aggregate search data portal that allows researchers to capture and review search interests. This dissertation analyzes real-time behavioral shifts resulting from tourism policy changes in Venice, Italy using Google Trends data. This work contributes to the current literature in DiD modeling, by using information-seeking behavior that is ahead of observable, lagged, outcomes. Through the integration of recent DiD advancements, this work further extends DiD applications in tourism econometrics, and a case-example of real-world tourism policy assessment. This dissertation highlights changes in search behavior immediately following policy implementation. Additionally, this work highlights Google Trends as …

Spatial Analysis And Machine Learning Integration For Nutritional Status Mapping Using Ann And Random Forest Models, Desi Anis Anggraini, Fachrul Kurniawan, Fresy Nugroho, Meidya Koeshardianto, Mohammad Iqbal Bachtiar

Knowledge Engineering and Data Science

Nutritional problems among children under five remain a major public health challenge. This research seeks to create a spatially oriented system for evaluating and mapping nutritional status utilizing Artificial Neural Network (ANN) and Random Forest (RF) algorithms. Data obtained from the Sumenep District Health Office included age, weight, height, and gender variables. Both models were trained using a 70:30 data ratio and evaluated with accuracy, precision, recall, and F1-score metrics. The ANN model achieved an accuracy of 95.8%, while the RF model reached 97.7%. Classification results were visualized through a Geographic Information System (GIS) to illustrate spatial distribution and identify …

Time Series Forecasting With Lstm: An Extensive Content Analysis, Andri Pranolo, Xiaofeng Zhou, Yingchi Mao

Knowledge Engineering and Data Science

This paper presents a comprehensive bibliometric and content review of the trend, architecture, and application of long short-term memory (LSTM) models for time series forecasting. The study aims to provide insights into the overall statistics and distribution of papers focused on LSTM for forecasting. Additionally, the research questions address the most highly cited papers based on LSTM approaches in forecasting, the most productive journals in this field, and identifying trends, gaps, summary tasks and their performance, datasets availability, and future research directions for LSTM in forecasting. This paper is a comprehensive review of LSTM for forecasting from 2017 to 2023 …

Cognitive Eeg Differentiation With Hypnosis-Based Noise Reduction And K-Harmonic Means For Personalized Brainwave Modeling, Ahmad Azhari, Dimas Chaerul Ekty Saputra

Knowledge Engineering and Data Science

This study investigates the integration of hypnosis-based noise reduction and K-Harmonic Means (KHM) clustering for personalized brainwave modeling using Electroencephalography (EEG) data. EEG signals were collected from 100 participants using a Neurosky Mindset sensor at the FP1 (prefrontal) location, with each subject performing nine standardized cognitive tasks such as breathing, memory recall, and mathematical problem-solving. Hypnosis was applied not as a filtering method but as a behavioral protocol to standardize subject conditions and minimize physiological and environmental noise. The EEG signals were sampled at 128 Hz and analyzed using KHM clustering with K=4K = 4K=4, resulting in a Silhouette Score …

Ahp–Python Framework For Multicriteria Modeling Of Rice Production In Asean, Mayang Anglingsari Putri, Risqy Siwi Pradini, Anuraga Jayanegara, Alexander Dimas Yonanta Putra

Knowledge Engineering and Data Science

Rice production is a key indicator of food security and agricultural stability in Southeast Asia, especially among Association of Southeast Asian Nations (ASEAN) countries. Despite shared regional goals, disparities in rice production remain, and previous studies mainly rely on descriptive statistics, lacking structured multicriteria decision-making frameworks and computational tools for cross-country comparisons. This study addresses these gaps by proposing an integrated Analytic Hierarchy Process (AHP)–Python framework to evaluate and rank ASEAN rice production from 2013 to 2022. Three criteria are used: Total Production Volume (K1), Production Growth Trend (K2), and Recent Year Performance (K3), capturing both long-term consistency and short-term …

Medical Malpractice, Gender-Affirming Care, And Insurance Law, Olivia Visio

Colorado Law Student Scholars

No abstract provided.

Immune Checkpoint Inhibitors: Friend Or Foe, Antonio Cordova, Jesse Powell, Whitney Elg-Salsman, Caroline Mcculley

Books, Presentations, Posters, Etc.

Introduction: • Many cancers use mechanisms to escape killing by the immunesystem. • Cancer cells can mimicimmune checkpoint proteins such as cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) ligand and the programmed death1 receptor ligand (PD-L1) toinhibit the T-cell response. • Immune checkpoint inhibitors (ICI's) are a novel set of monoclonalantibody cancer therapies. • ICI'sblockcheckpoint proteins from binding with their partner proteins oncancer cells thus allowing T-cells to kill tumor cells. • ICIs have promising anti-cancer results. • ICIs are also associated with immune related adverse events(irAEs), including dermatitis, pneumonitis, colitis,hepatitis, nephritis. • A rare but seriousirAEisICI-associated myositis causing bulbar and …

Governance And Innovation In Plastic Waste Management: The Case Of Japan, Minoo Tehrani, Yu Cui

Business Faculty Publications

This study investigates plastic waste management, focusing on Japan. The volume of plastic waste in Japan is more than eight million tons, and less than a quarter of the plastic waste is subjected to recycling. Considering that Japan is an archipelago consisting of a combination of four large islands and numerous smaller ones, plastic waste that enters the ocean poses significant threats to marine life, birds, other living beings, and beach pollution. This research explores the underlying factors that have made Japan one of the highest users of plastic. In addition, this study evaluates different strategies that are utilized in …

The Sensitivity Of The Human Development Index To Assumptions About Income, Maria C. Kula, Charles J. Moyer, Priniti Panday

Business Faculty Publications

The Human Development Index (HDI) aims to present a more robust picture of a country’s development status than that suggested by national income per capita. The HDI aggregates dimension indices based on transformed measures for the core values of health, education, and income per capita. Assumptions are made regarding the upper and lower bounds used to re-scale each core value into its dimension index, as well as the functional form used to create the HDI. The treatment of income in the HDI’s construction suggests incompatibilities with its underlying capability theory, which stresses the importance of individuals’ abilities to make their …

Green Cities Conference 2025--Program Booklet, Minoo Tehrani

Business Faculty Publications

No abstract provided.

Host-Associated Beneficial Gut Microbiota Boosts Induced Immunity And Limits Immune Deployment Costs In Bumblebees, Austin C. Calhoun, Teni Shosanya, Brenna K. Long, Jade K. Rehberger, Ben M. Sadd

Faculty Publications – Biological Sciences

1. Ecological immunology posits that variation in host resistance to infection may be attributed partly to the ecological and evolutionary costs of immunity. While the deployment of immune defence is necessary to combat pathogenic infection, hosts pay energetic and other costs for activation.
2. Host-associated beneficial microbiota have been shown to affect multiple host traits, including immunity, but how interactions with these microbial communities may mitigate the costs of immune activation remains an open question. For apid bees, including eusocial bumblebees, core members of the adult gut microbiota contribute to a variety of fitness-relevant traits and provide a key ecological and evolutionary …

Introduction, Malia Willey, Scott P. Libson

Faculty Scholarship

The introduction to Teaching Information Literacy by Discipline: Using and Creating Adaptations of the Framework.

Improving The Effectiveness Of Post-Anesthesia Care Unit Transitions: A Quality Improvement Initiative Using A Standardized Nurse Handoff Report Sheet, Myra Mcauley

Master's Theses and Capstones

Background: Effective communication during patient handoff in the post-anesthesia care unit (PACU) is essential to ensuring patient safety and continuity of care. Unstructured or inconsistent handoff processes can lead to information omissions and care delays.

Methods: This quality improvement project implemented a structured nurse-to-nurse handoff report tool in the PACU. A pre- and post-intervention survey design was used to assess nurses’ perceptions of handoff clarity, completeness, and satisfaction. Educational sessions supported implementation.

Results: Pre-intervention survey data revealed dissatisfaction with the current handoff process, citing frequent information gaps. Following implementation of the structured tool, post-survey results showed improved communication clarity, increased …

A Quality Improvement Project Reinforcing Nursing Education On Support Resources For Families In The Icu, Emily Siel

Master's Theses and Capstones

BACKGROUND: The Intensive Care Unit (ICU) is often a source of psychological, physical, social, financial, and spiritual distress for families of patients. Multidisciplinary support resources are available but are often underutilized. Nurses are uniquely positioned to assess needs and integrate resources into care. Therefore, enhancing nurses' ability to guide families to appropriate support resources may alleviate distress and promote holistic well-being for patients and their families.

METHODS: The Plan-Do-Study-Act (PDSA) model was used to guide this project. A pre-intervention survey assessed awareness, utilization, and perception of ownership. Following dissemination of the intervention, a post-survey evaluated improvements in knowledge and integration. …

Opioid Use Among Rural Medicare Beneficiaries, Yvonne Jonk Phd, Heidi O'Connor, Karen Pearson Mlis, Ma, Zachariah Croll Mph, Deborah Thayer, John Gale Ms

All Maine Rural Health Research Center Publications

Nationally, approximately 30% of Medicare Part D benefi-ciaries (13.4 million) had at least one opioid prescription in 2018, with over 350,000 beneficiaries receiving high dosages ≥120 morphine milligram equivalents (MME) /day.1 The CDC recommends avoiding dosages ≥90 MME/day.2 In 2019, state rates of Part D beneficiaries receiving opioid prescriptions have been as high as 42% (e.g., Ala-bama).1 Data from the 2015-2016 Medical Expenditure Panel Survey indicate that adults aged 65 and older living in rural areas were more likely than their urban counter-parts to obtain four or more opioid prescriptions during the year (11.1% versus 6.2%).

Reimagining The Role Of Maine’S Rural Hospitals: Preparing For The Future, John Gale

All Maine Rural Health Research Center Publications

Maine’s rural hospitals struggle with workforce shortages, high operating  costs, inadequate reimbursement, and patients bypassing their local hos pitals to access services outside of the community. Since 2013, four Maine  acute care hospitals have terminated inpatient operations. Evolving chal lenges include a declining need for inpatient beds, growth in Medicare  Advantage and value-based payment plans, escalating healthcare costs, and  the Reconciliation Act (HR 1), which contains provisions expected to harm ru ral hospitals, providers, and residents. To partially offset the anticipated neg ative impact of the bill, HR 1 also provides $50 billion in funding for a five-year  Rural Health …

Impact Of Minimally Processed Red Meat On Biomarkers Of Cognitive Decline, Saba Vaezi

Electronic Theses and Dissertations

No abstract provided.

Evaluation Of High-Moisture Ear Corn As A Roughage Source In Finishing Diets Fed To Beef Steers, Riley J. Leeson

Electronic Theses and Dissertations

The objective of this study was to evaluate the feedlot performance, rumination activity, and carcass characteristics of high moisture ear corn (HMEC) as a roughage source in finishing diets fed to beef steers. Backgrounded steers (n = 191; initial shrunk weight [4% BW] = 449 kg  23.9 kg) were assigned randomly to 1 of 24 pens (8 steers/pen) with pens randomly assigned to one of four dietary treatments (6 pens/treatment): control diet with hay fed at 10% roughage equivalency (RE; HAY10), or HMEC at either 14% (EAR14), 10% (EAR10), or 6% (EAR6) RE. High-moisture ear corn was assumed to …

A Research Project On The Feasibility Of The State Of California’S Mandate To Sell Only Zero-Emission (Electric) Vehicles By The Year 2035 For California And South Dakota, Sandeep Pudasaini

Electronic Theses and Dissertations

This research evaluates the feasibility of California's mandate to transition entirely to zero emission vehicles (ZEVs) by 2035 and explores the prospects of South Dakota adopting a similar policy. The study analyzes key factors such as infrastructure readiness, renewable energy capacity, material requirements for electric vehicle (EV) batteries, and socioeconomic variables that influence ZEV adoption. Feasibility studies like this are critical because large-scale policy mandates have far reached implications for energy systems, environmental outcomes, and economic planning. Understanding whether a state is equipped to meet such a goal allows policymakers to anticipate challenges, identify infrastructure gaps, and allocate resources more …

Comparative Evaluation Of Fungal Strains For The Bioprocessing Of Soybean Hulls Using Cheese Whey As Fermentation Medium, Ruchita Bhattarai

Electronic Theses and Dissertations

Globally, soybean is the most widely cultivated oilseed crops, and serve as the primary source of cooking oil, contributing to around 50% of global oilseed production. During the industrial processing of soybean oil, a significant amount of soybean hull (SH) is produced, which makes up about 8% of the grain yield, resulting in approximately 18–20 million tons of hulls, one of the largest by-products in the soybean industry. The hulls have limited commercial value and are primarily used as fiber additives in dairy cattle feed, but a large portion is still discarded as agricultural waste. Similarly, cheese whey (CW), a …

Quantifying Landscape Variability Of Dynamic Soil Properties In The James River Valley, Eastern South Dakota, Sage Reuter-Schmitt

Electronic Theses and Dissertations

Dynamic soil properties (DSP) are a great tool for monitoring land-use change, and they are frequently used as soil health metrics. The NRCS and other soil researchers often use repeating, single-point or nested-point DSP studies to monitor and better understand the effects of land management decisions. While these studies capture the temporal variability of DSPs, they overlook the field-scale spatial variability of DSPs. Soil organic carbon (SOC) provides critical services to the ecosystem and other environments. These traits, as well as its susceptibility to management decisions, make SOC an important soil health indicator and DSP. Measuring SOC is often time …

The Spatial And Temporal Dimensions Of Plant–Soil Feedback In Native Perennial Monocultures, Bret Lang

Electronic Theses and Dissertations

Plant-soil feedbacks (PSFs) describe how plants change their soil environment in ways that can either negatively or positively affect subsequent plant growth. In doing so, they offer an opportunity to connect ecological processes with agricultural practice. My dissertation examines PSFs created by native perennial monocultures, commonly used for native seed production, across time and space, and through soil legacies. Specifically, I focus on how plant species identity shapes both soil nutrient and soil microbial community responses. To address these questions, I conducted field experiments with monocultures of five forb species native to South Dakota and established plots with these species …

Impacts Of Early/Mid-Gestation Shearing On Umbilical Blood Flow And Lamb Birth Weight, Mara Johnson

Electronic Theses and Dissertations

Studies outside the USA have reported that shearing pregnant ewes during mid to late gestation increases lamb birth weight. Our hypothesis was that shearing pregnant ewes on day 50 of gestation would increase umbilical blood flow (UBF), fetal size, lambing and placental weights. Twenty-eight Polypay ewes were randomly assigned to two treatments: shorn (S) and sham-shorn (Control, CON) and divided in singleton (S: n=4; CON: n=4), twins (S: n=5; CON: n=5) and triplets (S: n=5; CON: n=5). Umbilical BF and fetal and placental measurements were obtained via ultrasonography every 10 days from day 50 to 110 of gestation. Lamb birth …

Impact Of Parental Involvement On Children’S Mental Health, Syeda Tasnime Kabir

Electronic Theses and Dissertations

This study estimates the causal effect of parental involvement on the mental health of primary school children in Bangladesh. Using an instrumental variables strategy that leverages local parental involvement norms, I find that increased parental involvement significantly reduces cognitive and emotional difficulties. Notably, I find that the protective effect of parental involvement varies by socio-economic context, showing weaker effects for children of mothers who married at an older age and those whose fathers live outside the household, but stronger effects in joint families. Furthermore, I identify two key mechanisms underlying these effects: accommodating parenting style and improved household hygiene practices. …

Isolation And Characterization Of Rhizobia Bacteria From Midwest Soils, Jr Loya

Electronic Theses and Dissertations

Symbiotic bacteria, known as rhizobia, can colonize the roots of legume plants and then convert atmospheric nitrogen into a usable form by the host through the process called biological nitrogen fixation (BNF). Many of these bacteria produce other plant-growth-promoting benefits, such as nutrient acquisition, phytohormone production, and the modification of plant stress responses. Agricultural inoculants made from these bacteria have helped reduce the need for man-made nitrogenous fertilizers, known causes of pollution and eutrophication. There are additional benefits in developing bacteria inoculants local to regional soils. The ability to survive and compete in Midwest soil and climates present an opportunity …