Digital Commons Network^™

Biological And Chemical Evaluation Of Amide-Based Cjoc42 Derivatives As Potential Gankyrin-Inhibitors For The Treatment Of Breast, Lung, And Liver Cancer, Benita Britton-George

Theses and Dissertations

Gankyrin is an ankyrin-repeat protein overexpressed in certain cancers and is responsible for cell growth and proliferation. Gankyrin is important to the development of many types of cancer, including breast, lung, and liver cancer. Consequently, gankyrin and its various protein-protein interactions, are prospective therapeutic targets for inhibiting the progression of certain cancers. In 2016, the first small molecule inhibitor of gankyrin, cjoc42, was discovered and subsequently demonstrated modest antiproliferative activity against liver cancer cells. Previous work from our lab demonstrated that replacing the sulfonate ester of cjoc42 with an amide group significantly improved gankyrin binding while enhancing antiproliferative activity against …

Gastronomy At The Heart Of Communication: A Locus Of Human Conviviality, Victoria M. O’Keefe

Theses and Dissertations

The significance of food over time is central to humanity and can aid in making people humane in a myriad of ways. This study seeks to (a) define the role of food in communication across sectors of global society and in the media realm (b) by analyzing a data set of all food related publications of the flagship magazine of UNESCO, The Courier, (c) through ethnographic study and inductive coding, I draw themes and trends that alter food communication from a multinational organization and pass the content through a theoretical lens and Large Language Model tool, to (d) illuminate implications …

The Psychometric Properties Of A Spanish Version Of The Attitudes And Beliefs Scale-2 Short Form In A Mexican Sample, Verónica Compeán

Theses and Dissertations

The Attitudes and Beliefs Scale 2-Short Form (ABS2-SF) is one of the most widely used measures of irrational and rational beliefs central to Rational Emotive Behavior Therapy (REBT). While evidence supports its reliability and validity in English-speaking populations, little is known about its applicability across cultural and linguistic groups. This study investigated the psychometric properties and cultural validity of the Spanish version of the ABS2-SF in a Mexican sample (n = 579) collected from undergraduate students in Tampico, Mexico, and compared them with English-speaking American non-clinical samples (n = 1,167). Using a bifactor multi-group confirmatory factor analysis (MG-CFA), I examined …

Neural Congruency Contrastive Learning Framework Validation Using Artificially Created Eeg Data For Dyslexia Research, Jacqueline M. Torres

Theses and Dissertations

Analysis of electroencephalogram (EEG) recordings in children with dyslexia has been commonly used to explore the neural mechanisms underlying reading disorders. Yet, challenges such as low signal-to-noise ratio (SNR), high inter-subject and inter-trial variability, and the inherently multivariate nature of EEG signals hinder the isolation of neural components elicited during reading diagnostic tests. To mitigate these challenges, the neural-congruency analysis framework was recently proposed, leveraging traditional machine learning optimization methods to incorporate domain knowledge about the congruency of neural responses across participants (i.e., consistent neural responses among proficient readers). However, the application of deep learning techniques, specifically contrastive learning, remains …

Propelling Whole-Cell Biosensor Creation By Leveraging Gene Fusion To Assemble Synthetic Functional Transcription Factors For The Detection Of Biomarkers, Samuel J. Verzino

Theses and Dissertations

Biosensors are analytical devices that leverage biological modules for the detection of molecules of interest. As customizable tools designed to aid in a wide array of diagnostics, these instruments are rapidly advancing the field of synthetic biology. While varied in their construction and purpose, biosensors are ultimately concerned with converting a physicochemical stimulus into a detectable signal. Among the many existing variants, whole-cell biosensors (WCBs) stand out due to their versatility and engineering potential. WCBs are a type of biosensor in which a physiologically active cell sustains an array of biomolecular elements - receptors, transporters, regulators, etc. - capable of …

The Long Shadow Of Pride And Prejudice On Contemporary Fictions Of Arranged Marriage And Marriages Of Alliance, Candice Belluscio

Theses and Dissertations

This dissertation is an examination of the conflicts between arranged marriage and companionate marriage in selected contemporary Anglo-Indian novels and novels about Orthodox Judaism. The project’s guiding focus is how modern ideals of independence and choice in marriage coexist simultaneously with older ideals of marriage as family or personal “alliance.” The dissertation has a historical chapter that shows that although ideals of companionate marriage have become norms of 20th century western society and literature, the term “companionate marriage” is a recent invention and convention, and that various degrees and forms of arranged marriage, or marriages of alliance, continue despite their …

Ripples Of Support: A Mixed Methods Study Of Bystander Behavior In The Context Of Sexual Assault Among College Students, Miranda Levy

Theses and Dissertations

Emerging adulthood represents a period of elevated risk for sexual assault (SA), particularly among college students. Students are not only potential victims or perpetrators but also bystanders—individuals who may witness or become aware of risky or harmful situations and must decide whether and how to respond. Understanding what influences students’ decisions to intervene as bystanders in SA contexts is critical to improving peer responses and fostering safer campus environments. This study used a concurrent mixed methods design to examine how college students’ knowledge of campus SA policies, personal history of victimization, prior experiences receiving help, and SA disclosure reactions relate …

Investigation Of The Binding Mechanisms Between Naphthenic Acids And Humic Acid Using Raman Spectroscopy And Computational Modeling, Jaelyn N. Palmer

Theses and Dissertations

The oil sand regions in Alberta, Canada have proven to be costly to the environment despite its economic benefits. The toxins produced during oil processing are sent to tailing ponds to be recycled, though often leaking into nearby waterways and soil. Naphthenic acids, NAs, are one of the most common toxins produced and have shown to be toxic to aquatic life, animals, and humans. As there is dissolved organic matter in tailing ponds and surrounding environments, tailing ponds often lead to NAs coming in contact with organic material. Humic acid, HA, is a major soil component that has been suspected …

Sustained Effects Of Neurofeedback On Children & Adolescents With Adhd: A Meta-Analysis, Dannielle A. Stephen

Theses and Dissertations

Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder diagnosed in the United States, with the most common form of treatment being psychostimulant medication. In the recent years there has been a growing concern among parents about starting their children on medication from a young age, prompting researchers to look at alternative methods. This will me a meta-analytic review of neurofeedback treatments to see if they are a feasible method in improving core behavioral symptoms and executive functions. All articles included in the review contained follow-up periods of 6 months or greater. There was a total of 468 participants across …

Embracing An Online Literary Identity: How Booktok Makes Literature More Accessible, Elizabeth Kaufmann

Theses and Dissertations

In this thesis I examine conversations that occur on TikTok’s literary corner, “BookTok.” My research involves focusing on the multimodality of BookTok, following comment sections and search options, as well as analyzing the components of the videos themselves. BookTok content creators focus on these features in order to spark literary conversation in an approachable way. These influencers heavily sway the app itself and the books being recommended. Extending my research beyond BookTok influencers, this essay seeks to understand the value of influencer backing on products towards their social legitimacy. Some users on TikTok are not fans of how the algorithm …

Severity Profiles Of Preschool-Aged Children And Their Associations With Maternal Help-Seeking: A Latent Profile Analysis, Samuel T. Jackson

Theses and Dissertations

Parents of preschoolers are more likely to seek treatment for childhood depression compared to anxiety and behavioral disorders. Atypicality and stability have been implicated in relation to help-seeking, but it is not known how they differ between disorders and whether such differences impact help-seeking. The current study grouped mothers based on their atypicality and stability appraisals across disorders; tested for differences in appraisals between disorders; and then tested for differences in help-seeking based on group membership. Participants were 272 adult mothers of preschool-aged children. Mothers read a series of vignettes describing preschool-aged children with depression, anxiety, and ADHD, and then …

How Therapists’ Perceptions Impact Disseminating And Implementing Trauma-Focused Cognitive-Behavioral Therapy, Maddi R. Gervasio

Theses and Dissertations

In the United States, 60% of youth experience a traumatic event before the age of 18 (Lawrence-Sidebottom et al., 2024) and childhood trauma is associated with a range of psychopathology. Although evidence-based therapies like Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT; Cohen et al., 2017) are available, only 14-22% of traumatized youth receive trauma-specific practices during treatment (Borntrager et al., 2013). Barriers to disseminating and implementing TF-CBT and similar interventions exist at the micro (e.g., therapist and client) and macro (e.g., systemic) levels (e.g., Gervasio & Herren, 2020). Emerging research focused on training in trauma therapists found that therapists’ negative perceptions about the …

Predicting Price Movements Of The S&P 500 Using Conventional And Alternative Market Indicators, Patrick M. Scarborough

Theses and Dissertations

This thesis investigates whether integrating alternative data sources with conventional financial indicators enhances S&P 500 forecasting accuracy in modern financial markets characterized by increased complexity and rapid information flows. The study analyzes daily S&P 500 returns using twelve predictor variables comprising conventional indicators (VIX volatility index, WTI crude oil, gold futures, AAA bond yields, Federal Funds Rate, Treasury yield spreads) and alternative data sources (Bitcoin returns, Daily News Sentiment Index, Indeed job postings, Economic Policy Uncertainty Index) across 1,341 observations from February 2020 to June 2025. The methodology employs ordinary least squares regression and ARIMAX(5,5) modeling with rigorous preprocessing including …

Sustainability Risk In Guyana’S Oil Sector: An Analytical Framework For Balancing Environmental And Economic Impacts, Kayla B. Moonsammy

Theses and Dissertations

This study investigates the sustainability risks posed by Guyana’s rapidly expanding oil sector, with particular focus on balancing economic benefits against environmental vulnerabilities. The primary aim is to develop a Sustainability Risk Index (SRI) that captures the multidimensional impacts of offshore oil development using an integrated data-driven framework. Specifically, this thesis examines how emissions, biodiversity loss, oil spill exposure, economic volatility, and social development indicators interact to influence sustainability outcomes in the context of Guyana’s transition into a major petroleum-producing nation. The research does not involve human participants; instead, it draws on publicly available datasets collected from 2015 to 2024. …

“Makings Of A Teenage Revolutionary”: An Analysis Of Power Through The Lenses Of Gender And Institution Within The Universes Of Frank Herbert’S Dune And Suzanne Collins’ The Hunger Games, Ayah Cruzado

Theses and Dissertations

It is my objective within this paper to lead us through an in depth analysis of both Katniss Everdeen and Paul Atriedes, investigating every feature of their lives especially in the ways that they compare and differ to one another, after all, it is their written depth and complexity that makes them and their novels so fascinating to the public and earning them fame. Through my exploration, I hope to shed some light on the ways these three elements work and coincide with one another within both narratives. To separate them from one another and simply examine them as independent …

Associations Between Psychoeducation And Measures Of Treatment Engagement In Trauma-Focused Cognitive Behavioral Therapy, Shari Lieblich

Theses and Dissertations

Despite the efficacy of TF-CBT, its effectiveness is compromised by high premature dropout or attrition rates. Psychoeducation, the first component of TF-CBT, provides both a rationale for engagement in treatment and normalizes symptoms to instill hope in youth and their caregivers. This component has been minimally examined as a predictor of later-phase symptom outcomes, mostly in adult trauma treatments, with mixed results. The goal of the current study is examine the influence of psychoeducation on participation-related variables in TF-CBT. Results indicate a positive association between the percentage of sessions of with psychoeducation and attrition and negative association with percentage session …

The Relationship Between Psychotherapist Self-Disclosure And Occupational And Emotional Variables, Kay Nikiforova

Theses and Dissertations

The effect of therapist self-disclosure practices on patients and the therapeutic relationship has long been debated. The historical trend of viewpoint toward self-disclosure began from predicting a negative, therapy-interfering stance to a growing openness towards the consideration that therapists sharing about themselves in session can have a positive effect on the patient. Evidence exists for both potential patient benefit and harm from therapists engaging in self-disclosure. Still, there is an increasing body of evidence that demonstrates that therapist self-disclosure benefits the therapeutic process, increases patient disclosure, and provides a more positive view of the therapeutic relationship. However, at present, there …

Nutrition Assessment Of Substance Use Population Compared To Control Population, Lalitha Indrani Dasari

Theses, Dissertations and Capstones

This study aims to evaluate and compare the nutritional status of individuals undergoing treatment for substance use disorder (SUD) with a matched control population. Poor nutrition, micronutrient deficiencies and malabsorption are common in individuals with SUD, potentially affecting recovery outcomes. This study involves collection of biometric data, demographic information, conducting a structured nutrition survey and performing a one-time blood draw of 35ml to assess key nutritional markers such as lipid panel, folic acid, vitamin B12, vitamin D, thyroid stimulating hormone (TSH), magnesium, selenium, chromium, zinc, copper and lithium. While the original protocol was designed to recruit approximately 110 participants across …

Analysis Of The Influence Of Telomere Length Variation On Flowering Time And Plant Fitness In Arabidopsis, Brianna Spadavecchia

Theses, Dissertations and Capstones

Telomeres are conserved structures at the ends of eukaryotic chromosomes that promote genome stability. In most eukaryotes, the DNA found within these protective end caps consists of short, G-rich nucleotide repeats. Cells with critically short telomeres face a variety of potential adverse outcomes such as end-to-end chromosome fusion, apoptosis, etc. The length of telomeric DNA varies substantially between different plant species and even between genotypes of the same species. A previous study using T-DNA mutants of the model plant Arabidopsis thaliana with long or short telomeres suggested that telomere length may be an adaptive trait. Specifically, for reproductive fitness, the …

Winter 2025, Augustana College, Rock Island Illinois

Augustana Magazine

No abstract provided.

Species-Specific Discrimination Of Bacterial Biofilms Using A Ratiometric Fluorescence Sensor Array And Machine Learning, Ritika Gupta, Aayushi Laliwala, Elena Muldiiarova, Kenneth W. Bayles, Denis Svechkarev, Marat Sadykov, Aaron M. Mohs

Journal Articles: Pathology and Microbiology

Biofilms are intricate bacterial communities encased in a self-produced extracellular matrix (ECM) of DNA, lipids, proteins, and polysaccharides. The diverse ECM composition across bacterial species significantly influences the progression of biofilm-associated infections, making precise identification crucial for effective treatment. Traditional methods such as biochemical assays, MALDI-TOF mass spectrometry, DNA sequencing and culturing provide valuable insights but have notable drawbacks, including time-consuming procedures, high costs, and the need for specialized equipment and trained personnel. These limitations hinder the rapid and widespread adoption of biofilm identification in clinical settings, underscoring the need for more streamlined, accurate, and accessible methods. In this study, …

The Queen’S Gambit, Jennifer Stegman

Theses & ETDs

The Queen’s Gambit by Walter Tevis is both a novel and a Netflix mini series about a female chess prodigy, Beth Harmon, navigating the world of chess in the mid-twentieth century. The adaptation to screen in 2020 sparked a global interest in chess, especially among women. My thesis analyzes the adaptation from novel to series, the use of music as a narrative tool, the historical context, the chess games themselves, and the character development. I will be integrating my personal experience as a female chess player, and focusing on how my evolution and experience as a player mirrors Beth’s. I …

The Power Within: An Exploration Of Self-Affirmation Interventions And Their Effects On The Well-Being And Writing Self-Efficacy Of College Students, Sonja Swanson

Theses & ETDs

College students are a focus of many studies on well-being and academic performance. This is because they must navigate a newfound independence juggling many responsibilities while consistently submitting assignments for their classes. Most often these assignments involve writing, a notable struggle for those new to taking care of their mental health. The current study conducted a self-affirmation intervention to investigate the effects on college student eudaimonic well-being, hedonic well-being, and writing self-efficacy. Sixteen students participated in a three-week intervention involving two surveys and three writing tasks. The selfaffirmation group completed values-affirmation writing tasks and the control group completed a writing …

Applications Of Marine Optics: Satellite-Derived Bathymetry, Light Attenuation Measurements Via Multi-Spectral Light Sensors, And Colored Dissolved Organic Matter Spectral Analysis, Noah Tyler

Theses & ETDs

This thesis aims to explore three applications of the field of marine optics. First, some marine optical principles are applied to satellite imagery to generate satellite-derived bathymetry (SDB) charts for Sarasota Bay, FL. SDB charts were successfully created using satellite images from July and August of 2023. Unique terrain features, such as the intercoastal waterway, can be seen in the SDB charts. Next, a multi-spectral light sensor system (MSLSs) was developed so it could be utilized to measure attenuation as a proxy for turbidity using marine optics concepts. The MSLSs were deployed in Sarasota Bay to collect attenuation data. The …

Patient Autonomy, Public Safety, And Drivers With Cognitive Decline, Sharona Hoffman, Cassandra Burke Robertson

Faculty Publications

With a growing elderly population, cognitive decline in drivers has become a significant public safety concern. Currently, over thirty-two million individuals who are seventy or older have driver’s licenses, and that number is growing quickly. In addition, almost ten percent of U.S. seniors (those sixty-five and older) have dementia, and an additional twenty-two percent have mild cognitive impairment. Between a quarter and a half of individuals with mild to moderate dementia still drive. As cognitive abilities such as memory, attention, and decision-making skills deteriorate, a driver's ability to operate a vehicle safely can be compromised. This not only puts the …

Practicing Intercultural Discipleship, Akali Nya

Academic Books

No abstract provided.

Principles Of Advanced Manufacturing For Engineers, Xin Zhao, Walid Asad, Subha Majumder, Chenyang Zhu

Manufacturing

No abstract provided.

What Does Npep Mean To Us?, Northwestern Prison Education Program

JCLC Online

The Northwestern Prison Education Program (NPEP) provides currently incarcerated individuals across Illinois an undergraduate education from Northwestern University. At Stateville and Logan Correctional Centers, admitted NPEP students work toward a Bachelor of Science degree, taking a full course load taught by Northwestern professors within the prisons’ walls. On November 14, 2023, the inaugural cohort of NPEP students at Stateville graduated from the program, making history as the first incarcerated students in the United States to earn a bachelor’s degree from a top ten university as ranked by U.S. News and World Report. This piece is a collection of personal reflections …

The Meaning Of Life, In Michigan: Mercy From Life Sentences Under The State Constitution, Molly Bernstein, David Shapiro

JCLC Online

Properly understood, the “cruel or unusual” punishment clause of the Michigan Constitution grants every person sentenced to life in prison a meaningful right to obtain release through rehabilitation. Today, however, Michigan has among the nation’s largest populations of people serving both formal and de facto life sentences without any meaningful possibility of release.

In 1850, Michigan revised its state constitution to prohibit “cruel or unusual punishment,” creating a contrast with the conjunctive “cruel and unusual punishments” clause of the federal Eighth Amendment. This disjunctive prohibition, which subsequent Michigan constitutional conventions retained, prohibits both “cruel” sentences and “unusual” sentences. We argue …

For Official Violence, The Devil's In The Dehumanizing Details, Rachel Kincaid

JCLC Online

In Excessive Force in Prison, Professor Sharon Dolovich tackles the shortcomings of the Eighth Amendment’s cruel and unusual punishment doctrine to govern uses of official violence against prisoners. She argues that law enforcement officers owe a duty of care and protection to incarcerated people, but that duty of care and protection is undermined by the dehumanization and demonization of prisoners. Professor Dolovich thus advocates for shifting the doctrinal standard for excessive force under the Eighth Amendment to one based on objective reasonableness, paired with jury instructions explicitly reminding jurors of incarcerated victims’ humanity. To counteract the vagaries of such an …