Digital Commons Network^™

Clinical, Hormonal, And Treatment Outcomes In 247 Patients With Acromegaly: A Single Tertiary Center Experience, Ümran Gül, Beki̇r Uçan, Hayri̇ Bostan, Hakan Düğer, Hayri̇ Kertmen, Caner Ünlüer, Hali̇l Durantaş, Oğulcan Boz, Ceren Karaçalik Ünver, Burak Menekşe, Sema Hepşen, İlknur Öztürk Ünsal, Mustafa Özbek, Erman Çakal, Muhammed Kizilgül

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the demographic, clinical, and hormonal characteristics; comorbidities; surgical pathology; treatment modalities; and long-term clinical outcomes of patients diagnosed with and managed for acromegaly at our tertiary referral center over a 15-year period.

Materials and methods: Between 2010 and 2024, 247 patients with acromegaly were evaluated. Diagnosis and biochemical remission were determined according to the 2024 Acromegaly Consensus Criteria.

Results: The median follow-up duration was 8 years (IQR: 3–14). At the time of diagnosis, the most frequent pituitary hormone deficiency was secondary adrenal insufficiency, present in 17.8% of patients. The most common comorbidities were hypertension …

A Caveat Regarding The Unfolding Argument: Implications Of Plasticity, Viknas N. O'Reilly-Shah, Alessandro Maria Selvitella, Aaron Schurger

Psychology Faculty Articles and Research

The unfolding argument in the neuroscience of consciousness posits that causal structure cannot account for consciousness because any recurrent neural network (RNN) can be “unfolded” into a functionally equivalent feedforward neural network (FNN) with identical input–output behavior. Subsequent debate has focused on dynamical properties and philosophy of science critiques. We examine a boundary condition on the unfolding argument for RNN systems with rapid plasticity in their connection weights. We demonstrate through rigorous mathematical proofs that rapid plasticity negates the functional equivalence between the RNN and the FNN. Our proofs address history-dependent plasticity, dynamical systems analysis, information-theoretic considerations, perturbational stability, complexity …

Using In-Home Air Quality Monitoring To Reduce Cannabis Secondhand Smoke Exposure In Children: Quantitative Pilot Feasibility Study, Vincent Berardi, Bradley N. Collins, Laura M. Glynn, Eusabeia Silfanus, Darby G. Lyons, Stephen J. Lepore

Psychology Faculty Articles and Research

Background: An estimated 5 to 8 million US children live with a parent who uses cannabis, and most cannabis users report smoking cannabis inside their homes, placing children at risk for cannabis secondhand smoke (cSHS) exposure. Indoor air quality (IAQ) monitoring provides real-time feedback on airborne pollutants and has shown promise in reducing in-home tobacco secondhand smoke exposure, suggesting its potential as an effective harm reduction strategy for cSHS.

Objective: This pilot study evaluated the feasibility, acceptability, and preliminary effectiveness of using low-cost, off-the-shelf IAQ monitors to increase caregivers’ awareness of children’s cSHS exposure risk and to change …

Resource Highlight: Accessdermatologydxrx, Joanne Romano

TMC Library Newsletter (2015-)

Try AccessDermatologyDxRx! It is your go-to Access collection in dermatology featuring core texts, review questions, cases, videos, 3D modules, and more, including: Fitzpatrick’s Dermatology Flashcards, Weinberg’s Color Atlas of Pediatric Dermatology and Taylor and Kelly’s Dermatology for Skin of Color.  Try it today!

The Power Of Proximity: Driving Hand Hygiene Compliance Through Sanitizer Placement, Jennifer E. Jones, Eric Van Middendorp, Leanne Wendt

Posters

Hand hygiene is the cornerstone of infection prevention in healthcare settings and is particularly critical in the Neonatal Intensive Care Unit (NICU) where patients are highly vulnerable due to immature immune systems and frequent exposure to invasive procedures. Healthcare associated infections (HAIs) remain a significant cause of morbidity and mortality among neonates. Evidence consistently identifies proper hand hygiene as the single most effective intervention to reduce HAIs in NICUs. Despite its simplicity, compliance among healthcare workers is often suboptimal, influenced by factors such as workload and accessibility of hand hygiene resources.

Quality In Action: A Systematic Approach To Central Line Associated Bloodstream Infection Prevention, Jennifer E. Jones, Maggie Simons, Sherri Hoard, Gabriel Laney, Adam Nicholson, Victoria Springvloed, Tracy James, Erica Tuffs

Posters

Central line associated bloodstream infections (CLABSIs) are a major source of morbidity, mortality, and increased healthcare costs in hospitalized patients. Reducing CLABSI rates requires more than isolated interventions; it demands a coordinated, multi-disciplinary strategy that addresses clinical practice, workflow and organizational culture.

From Scenario To Safety: Simulation As A Catalyst For Infection Prevention, Brianne M. Bachman, Jennifer E. Jones, Jessica L. Mcclusky, Mallory Davis

Posters

Simulation-based education has emerged as a transformative tool in healthcare, bridging the gap between theoretical knowledge and clinical practice.

In the realm of infection prevention, simulation offers a controlled, risk-free environment to reinforce essential protocols, build competency, and identify system level vulnerabilities before harm occurs.

Improving Documentation Accuracy Of Surgical Site Infection Prevention Bundles Using Implementation Science Frameworks, Laura Fraser, Lynn M. Sackett-Hodge, Michelle Schaeffer, Pamela S. Bozigar

Conference Presentation Abstracts

Accurate documentation of Surgical Site Infection (SSI) prevention bundle components is essential for quality improvement and patient safety. In National Healthcare Safety Network (NHSN)-reported colon (COLO) and hysterectomy (HYST) procedures, incomplete or inconsistent documentation undermines bundle fidelity and limits evaluation of outcomes. This initiative aims to determine whether embedding evidence-based interventions within implementation science frameworks improves documentation accuracy and ensures sustainability.

Upcoming Holidays, Katie Prentice

TMC Library Newsletter (2015-)

No abstract provided.

Trophic Transfer Of Fluorescent Polyethylene Microplastics In A Simplified Artemia–Oreochromis Aquatic Food Chain, Dativa J. Shilla

Tanzania Journal of Science

Microplastics (MPs) are pervasive contaminants in aquatic ecosystems, yet experimental evidence of their trophic transfer within tropical African food webs remains scarce. This study provides experimental evidence of indirect trophic transfer of microplastics from Artemia salina to Oreochromis urolepis, a cichlid species of ecological and economic importance in African inland and coastal waters. A simplified two-level food chain was established by exposing A. salina nauplii to fluorescent polyethylene microplastics (10–20 µm; 1, 10, and 100 mg L⁻¹) and subsequently feeding them to juvenile O. urolepis under controlled laboratory conditions. These concentrations were selected to represent a range of exposure levels …

The Helminthic Status Of Selected Tanzanian Subterranean Rodents, The Root-Rats (Spalacidae: Tachyoryctes Splendens) And Emini Silvery Mole-Rats (Bathyergidae: Heliophobius Argenteocinereus Emini), Jestina V. Katandukila

Tanzania Journal of Science

Root-rats (Tachyoryctes splendens) and emini silvery mole-rats (Heliophobius argenteocinereus emini) are common subterranean rodents that are essential component of the ecosystem. They serve as prey for small to medium-sized carnivores and birds of prey but their role as hosts to parasites is limited. The present study, explored the Gastrointestinal Tract (GIT) contents of 40 rodents (20 T. splendens and 20 H. a. emini, respectively) to acquire information on parasites diversity of these mammals. The GIT contents from subterranean rodents in a sex ratio of 1:1 were examined under a compound microscope to isolate helminths. The isolated helminths belonged to the …

Optimization Of Bio-Briquettes Production From Cassava Stems Co-Blended With Sisal Bole Bagasse Using Response Surface Methodology, Agnes Nshoma Msobi, Neema O. Msuya, Kando Khalifa Janga

Tanzania Journal of Science

This research aimed at producing bio-briquettes from cassava stems and sisal bole bagasse as an alternative source of cooking energy. A Response Surface Methodology (RSM) with Face - Centered Central Composite Design (FCCCD) featured a multi-objective optimization of the effect of the production parameters, focusing on maximizing char yield and Higher Heating Value (HHV) of the produced briquette while minimizing carbonization temperature and residence time. The findings showed that bio-briquettes produced at the lowest temperature (250 ℃) and residence time (30 min) and the blending ratio of 75% by 25% had the highest char yield of 76.92% and HHV of …

Automated Alerts To Improve Timely Evaluation And Treatment Of Valvular Heart Disease: The Alert Trial., Wayne B Batchelor, Brian R Lindman, Megan Coylewright, Antoine Keller, Brody Wehman, Adnan Chhatriwalla, Sandeep M Patel, Kevin Stiver, Firas Zahr, Miguel Sotelo, Dongho Shin, Chris Rogers, Graeme L Hickey, Jamie Williams, Myra Fan, Sreekanth Vemulapalli

Medical Education Articles

BACKGROUND: Severe aortic stenosis (AS) and mitral regurgitation (MR) are frequently undertreated and characterized by persistent sex, racial and ethnic, socioeconomic, and geographic disparities despite effective valve therapies. Whether automated electronic clinician notification (ECN) alerts improve the evaluation and treatment of AS and MR across health systems is unknown.

OBJECTIVES: The purpose of this study was to evaluate whether ECN alerts improve guideline-directed evaluation and treatment of significant AS and MR across multiple health systems.

METHODS: ALERT is a multisystem, cluster-randomized clinical trial including clinicians ordering echocardiograms across 5 U.S. health systems encompassing 35 hospitals between August 2024 and September …

Process Development Of C63000 Nickel Aluminum Bronze For Cold Spray, Trent Lamont

Dissertations and Theses

Nickel-aluminum bronze (NAB) is widely used for maritime components but is traditionally limited to casting due to its complex microstructure. Fine β′ phase formation in NAB is governed by the solid-state transformation of the high-temperature β phase during cooling. This ordered martensitic β′ forms via diffusionless transformation, contributing to brittleness. Conventional metal additive manufacturing (AM) techniques, such as Laser Powder Bed Fusion and Directed Energy Deposition, experience high in-process cooling rates that promote fine β′ formation, compromising mechanical performance. Powder production similarly suffers from β′ formation, often requiring additional processing. Cold Mechanically Derived (CMD) powders, produced from wrought feedstocks, retain …

Comparative Effectiveness Of Olmesartan Medoxomil In Monotherapy And Combination Therapy With Other Arb Medications: Literature Review, Deepika Saini

University Honors Theses

Hypertension remains one of the leading health issues; however, the awareness and control remain limited, with approximately 1.4 billion people affected by hypertension, yet only one in five has the condition effectively controlled. Despite the availability of effective treatments, knowledge and awareness remain limited. Angiotensin II receptor blockers (ARBs) are widely used antihypertensive medications because of their efficacy and safety profiles. Among these, Olmesartan Medoxomil has emerged as a prominent option, demonstrating strong efficacy in lowering blood pressure, both as monotherapy and in combination with other antihypertensive agents.

This thesis examines the comparative effectiveness of Olmesartan Medoxomil versus other ARBs …

Pinnlab: An Interactive Dashboard For Teaching Data-Driven Parameter Estimation In Differential Equations Using Physics-Informed Neural Networks, Mohan J. Parthasarathy, Padmanabhan Seshaiyer

CODEE Journal

Undergraduate instruction in ordinary differential equations (ODEs) is typically organized around the forward problem: finding solution trajectories when the governing equation and its parameters are known. In scientific practice, however, inverse problems are often more relevant, requiring unknown parameters to be inferred from noisy observations while assessing whether a proposed model is consistent with the data. We introduce PINNLab, an open-source MATLAB dashboard designed to help undergraduate students explore inverse modeling through physics-informed neural networks (PINNs). PINNLab presents PINNs as a complementary data-driven framework that connects differential equations, optimization, empirical data, and scientific machine learning. The instructional sequence is organized …

Pancreatitis Risk Genes Play A Major Role In Pediatric Pancreatitis: Insights From The International Study Group Of Pediatric Pancreatitis: In Search For A Cure, Maisam Abu-El-Haija, Wenying Zhang, Fuchenchu Wang, Gretchen Cress, Brian Dawson, Xiaoping Su, Tyler Thompson, Nicole Kotha, Ankur Chugh, Reuven Zev Cohen, Elissa M Downs, Douglas S Fishman, A Jay Freeman, Cheryl E Gariepy, Matthew J Giefer, Tanja Y Gonska, Phil Greer, Amit S Grover, Andrew Y J Liman, Douglas Lindblad, Quin Y Liu, Asim Maqbool, Jacob A Mark, Brian A Mcferron, Megha S Mehta, Veronique D Morinville, Kenneth Ng, Robert A Noel, Chee Y Ooi, Emily R Perito, Michael Wilschanski, Yuhua Zheng, Ying Yuan, David C Whitcomb, Aliye Uc, Mark Lowe, Consortium For The Study Of Chronic Pancreatitis, Diabetes, And Pancreatic Cancer (Cpdpc)

Faculty, Staff and Students Publications

Background & aims: Clinical data show that genetic variants are significant risk factors for acute recurrent pancreatitis and chronic pancreatitis. To expand the understanding of the role of genetics in acute recurrent pancreatitis and chronic pancreatitis, high-throughput next-generation sequencing of 14 genes was completed in a multicenter pediatric cohort.

Methods: A cross-sectional study involving 944 pediatric patients with acute recurrent pancreatitis or chronic pancreatitis was conducted. CASR, CEL, CFTR, CLDN2, CPA1, CTRC, GGT1, PRSS1, PRSS2, PRSS3, SBDS, SLC26A9, SPINK1, and UBR1 were sequenced. The frequencies of identified variants were compared with frequencies in the genome aggregation database. Group differences were …

Hp1bp3 Loss Links Chromatin Reorganization To Metabolic Vulnerability In Glioma, Brittney Lozzi, Taylor A Gatesman, Pushan Dasgupta, Debosmita Sardar, Yeunjung Ko, Chenyu Mao, Hsiao-Chi Chen, Rachel N Curry, Dongjoo Choi, Carrie A Mohila, Melissa L Bondy, Ganesh Rao, Marco Gallo, Sameer Agnihotri, Benjamin Deneen

Duncan NRI Faculty and Staff Publications

High-grade gliomas (HGGs) are aggressive brain tumors with poor prognosis, driven in part by metabolic and epigenetic adaptations. Methionine metabolism supports HGG growth by supplying S-adenosylmethionine for methylation reactions, yet how nutrient availability influences chromatin organization in HGG remains incompletely understood. Using an immunocompetent mouse model of HGG, we found that dietary methionine restriction reduced tumor proliferation, extended survival, and induced partial nuclear inversion. We identified Hp1bp3 as a key regulator of tumor growth that functions by interacting with nuclear tethering proteins to mediate chromatin reorganization. Loss of Hp1bp3 results in the upregulation of histone demethylases leading to selective depletion …

Broadly Reactive Human Monoclonal Antibodies Targeting Influenza A Nucleoprotein Lack Protective Activity In Vivo, Walter N Harrington, David C Brice, Aaron J Schmitz, Jackson S Turner, Rafael Brent, Philip A Mudd, Ali H Ellebedy, Richard J Webby

2020-Current year OA Pubs

The antibody response to influenza virus infection targets numerous viral proteins, with those specific for the hemagglutinin (HA) and neuraminidase (NA) surface glycoproteins being the most extensively studied. Antibodies to HA and NA function as independent immune correlates of protection and form the basis of most vaccine approaches. In contrast, the contribution of antibodies to other viral proteins such as the nucleoprotein (NP) remains unclear, and existing studies have reached conflicting conclusions. In this work, we examined three human monoclonal NP antibodies isolated from plasmablasts of two individuals naturally infected with influenza A virus (IAV) during the 2018-2019 influenza season. …

Gci #320: Swarm Recovery & Pelletization System (Srps), Michael Victor Caldwell Mr.

Defensive Publications Series

This invention discloses a mobile, field‑deployable, modular processing platform that intercepts migrating Mormon cricket bands and converts them into:

• Nitrogen‑rich fertilizer pellets

• Chitin soil amendments

• Biochar‑enhanced carbon‑rich pellets

The system is built in two layers:

Version A — Real‑World, Low‑Regulation System

Uses only proven agricultural machinery and heat‑pasteurization.

This version can be built immediately with no exotic components.

Version B — Advanced GCI Upgrade Modules

Adds Phoenix‑Cracker cavitation, VABR acoustic‑vortex refining, MASA acoustic herding, and Omni‑Vortex power systems.

These are optional bolt‑on modules.

This disclosure includes complete subsystem descriptions, mechanical logic, operational workflow, and engineering rationale.

Hdfs Grpc Writer: A Unified High-Performance Data Ingestion Engine, Raouf Khan Mr, Mahendra Yadav Mr

Defensive Publications Series

The present disclosure relates to a method and a system for HDFS gRPC writer for unified, high-performance data ingestion system designed to modernize the way both streaming and batch data are written into HDFS. The present disclosure suggests single, scalable gRPC-based ingestion interface capable of handling multiple data formats, while also efficiently managing batching, schema evolution, fault tolerance, and security. After receiving the data, the present disclosure suggests HDFS gRPC writer addresses the small files problem at its source by implementing intelligent size-based and time-based batching. Thereafter, the present disclosure ensures optimal HDFS file sizes without the need for downstream …

Notifications Management Via Attention Budgeting And Collision Detection, Ashwin Goyal

Defensive Publications Series

Notifications to mobile devices that persist beyond their contextually relevant windows cease to be informative prompts and can become annoyances. Current notification paradigms treat the notification tray as a static, append-only data repository, placing the burden of notification lifecycle management and cleanup on the user. This disclosure describes automated notifications management techniques that transform notifications from static payloads into dynamic, self-resolving objects. The techniques include temporal notifications-lifecycle management, app-ecosystem intelligence, state synchronization, spatial optimization, device context, etc. Leveraging automated notification updates and retractions, the techniques reduce or eliminate disadvantages of persistent notifications. The techniques change the notification management paradigm by …

Defensive Publication: A Proactive Compliance And Security Enforcement Gateway For Model Context Protocol (Mcp) Servers And Agentic Ai Systems With Two-Stage Bidirectional Inspection, Immutable Sensitivity-Aware Routing, And Tamper-Evident Audit, Tiago Rosado

Defensive Publications Series

This document discloses the architecture of a proactive compliance and security enforcement gateway that mediates all traffic between AI agents (or human clients) and the large language models (LLMs) and Model Context Protocol (MCP) tool servers they invoke. The gateway operates as a reverse proxy enforcing a fail-closed posture: every inbound prompt and every outbound response is inspected by a two-stage pipeline — a sub-5ms offline machine -learning classifier followed by a configurable LLM-based deep-inspection backend — before crossing the boundary. A three-layer sensitivity pipeline (regex, ML, LLM) classifies payloads and routes data graded CONFIDENTIAL or RESTRICTED to local-only models …

Meningioma Detection From Mri: A Comparative Study Of Deep Learning Models, A. H. Doha, Sandi Jennifer, Fatima Alabdaly

AUIQ Complementary Biological System

This study compares several deep learning models including DenseNet20, CNN, ResNet50, VGG19, EfficientNet-B3, MobileNetV2, NASNetMobile, Xception to automatically classify brain meningiomas from MRI scans. A public dataset was used to evaluate the proposed model. All models were trained, validated, and tested on this dataset. Because meningiomas are common and manual reads, the goal is to speed and standardize diagnosis. Our main contribution is pairing a high-accuracy classifier with deep learning models. Among all models, DenseNet201 performed best, reaching 0.991% accuracy and reliably separating tumorous from non-tumorous MRIs. Future work will expand the dataset and incorporate stronger segmentation to further boost …

Hand Mapping: Our Sexual Health Is (Not) In Our Hands, Laura L. Ellingson

Feminist Pedagogy

This Original Teaching Activity introduces hand mapping, an assignment based on the body mapping method, in the context of a communication and gender studies course. Hand mapping can be adapted to interpersonal, organizational, intercultural, and media courses that address identities, intersectionality, communication, culture, and power in different contexts and mediums. Students outline their hands on paper and artfully embellish them as a visual representation of important takeaways or lessons they learned in the course in response to the prompt, “Our sexual health is (not) in our hands.” Students write an “artist’s statement” explaining meanings of color, symbolism, and design.

Ignatian Pedagogy For Engaged, Reflective, And Inclusive Learning: New Insights On A Treasured Tradition, Jennifer Tilghman-Havens, Jennifer Loertscher, David Green, Kerry S. Von Esch

Jesuit Higher Education: A Journal

Ignatian pedagogy is the philosophy and methodology for teaching and learning that evolved from the wisdom accumulated from 500 years of Jesuit education. The Ignatian approach views education as a collaborative process that transforms students and teachers, preparing them for moral and ethical action in the world. While the core values of Jesuit education have remained constant, the changing demographics within our Jesuit communities and among the faculty and staff of our institutions offer an opportunity to celebrate its many intersections with peer-reviewed research on effective pedagogical approaches that center students and foster justice, diversity, equity, and inclusion. In this …

Faculty And Staff Formation In Jesuit Higher Education: The Scholarship And Art Of Accompaniment, Belle Liang, Maria Gregoire, Elisa Liang

Jesuit Higher Education: A Journal

This study examines the formative impact of selected faculty and staff formation initiatives offered at Boston College, with particular attention to those shaped by Ignatian spirituality. Drawing on qualitative survey data from 134 participants, the analysis identifies interrelated conditions through which formation is experienced as a coherent process rather than a set of discrete programs. Across initiatives, renewal and vocational clarity were most often described through four conditions: People, Pause, Place, and Purpose, understood here as the alignment of values, commitments, and lived practice. Presence emerged as the relational medium through which People, Pause, Place, and Purpose became formative. Presence …

Integral Education, Institutional Solidarity: A Response To Arturo Sosa’S 2025 Iaju Address, Paul L. Lynch

Jesuit Higher Education: A Journal

During the 2025 meeting of the International Association of Jesuit Universities (IAJU) at the Pontifica Universidad Javeriana in Bogotá, Colombia, Jesuit Superior General Arturo Sosa offered the keynote address, “The Jesuit University: Witness to Hope, Creative and Dialogical Presence.” He urged the global university apostolate to respond to our common challenges: the climate crisis, political reactionism, institutional mistrust, and economic inequality. The Jesuit university, he insisted, must reimagine itself in order to respond to these threats. But the precise manner in which Jesuit universities should respond must still be articulated. This essay begins that project. It opens with an analysis …

Forming Physicians For Others: The Identity Of The Jesuit Catholic Medical School, John Hardt, David G. De Marco Sj

Jesuit Higher Education: A Journal

Forming Physicians for Others: The Identity of the Jesuit Catholic Medical School

The Jesuit medical school accepts a widely-acknowledged telos: the preparation of the medical student to offer excellent patient care. It pursues this telos, however, through the distinctiveness of Ignatian formation, which finds expression in each domain of undergraduate medical education. This formative commitment, oriented toward and witnessing to an appreciation of the unconditional worth of the human being, may empower a subset of medical students—who are engaged by a life of faith and open to the transcendent invitation of their lives—to experience an even more fundamental transformation—one that …

Summary Of The 2025 Western Bird Banding Association Annual Meeting, Danielle Kaschube

North American Bird Bander

No abstract provided.