Digital Commons Network^™

Corporate Eldercare Responsibility: Forging A Strategic Approach To Sustaining Work–Care Balance, Kazunori Kobayashi, Gabriel Eweje, Mayowa Babalola, Tazeeb Rajwani

Research outputs 2022 to 2026

Purpose – Population ageing is intensifying pressures on employees with eldercare responsibilities, yet eldercare remains weakly addressed within corporate social responsibility (CSR) and business strategy research. This study aims to examine how firms strategically respond to these emerging pressures and develops the concept of corporate eldercare responsibility. Design/methodology/approach – The study draws on qualitative interviews with senior managers in large Japanese corporations. The analysis focuses on how firms interpret eldercare-related challenges and translate them into organisational responses within existing employment and CSR strategy frameworks. Findings – The findings identify two distinct CSR logics shaping organisational responses. Provision-focused practices extend supports …

Describing Propagation Of Carbapenem-Resistant Acinetobacter Baumannii Through Comparative Genomics And Phenotypic Analysis Of Modern-Day Clinical Isolates, Emma Graffice

ETDs from 2020-2029

Understanding the genomic structure of bacterial populations is essential for tracking antimicrobial resistance and informing public health strategies to prevent spread of multidrug resistant organisms. In this study, we investigated the diversity and distribution of carbapenem-resistant Acinetobacter baumannii (CRAb) lineages across a major healthcare system in the U.S. Deep South through both retrospective and prospective isolate collection. Our analysis revealed a heterogeneous population composed of multiple genotypically and phenotypically distinct lineages. To improve the resolution of lineage classification, we applied average nucleotide identity (ANI) as a high-resolution metric for comparative genomics. A ≥99% ANI threshold effectively delineated lineages, outperforming traditional …

Contribution Of Phosphorylation To Hp1a Function, James Walts

ETDs from 2020-2029

Heterochromatin Protein 1 (HP1) family members are highly conserved, non-histone chromosomal proteins essential for heterochromatin formation and transcriptional regulation. In Drosophila melanogaster, HP1a functions both as a transcriptional repressor and activator, as well as other functions, and undergoes post-translational modifications, including phosphorylation. The functional consequences of HP1a phosphorylation remain largely unexplored. This thesis investigates the role of phosphorylation at serines 89/90/91 (S899091) of HP1a by generating two mutant alleles: a phospho-mimic (SE) and a phospho-block (SA). Both alleles produce stable mRNA transcripts; however, Western blot analysis revealed reduced protein accumulation relative to wildtype HP1a. Homozygous phospho-block animals are embryonic lethal …

Jnk Signaling Impacts Car-T Cell Effector Function, Charles Kuhlmann

ETDs from 2020-2029

The potent cytotoxic activity of T cells serves as a natural defense against cancers. Chimeric antigen receptor (CAR) T cell therapy represents a strategy for harnessing T cells against advanced tumors. CAR-T cell therapy has seen striking success against hematologic malignancies, prompting its application to new diseases. Ovarian cancer is a highly lethal disease characterized by frequent recurrence and aggressive nature, prompting the investigation of CAR-T cell therapy as a salvage regimen. However, like in other solid tumors, the early performance of CAR-T cell therapy in ovarian cancer is poor. While many strategies exist for improving the longevity of CAR-T …

Culturally Informed Approaches To Support Perinatal Mental Health: Perceptions And Experiences Of Perinatal Depression And Support Systems Among Postpartum African-Born Women In The United States, Joyce O. Imafidon

ETDs from 2020-2029

Perinatal mental health (PMH) of African-born women (ABW) is underrepresented in research and practice in the United States (US) despite known consequences of poor mental wellbeing on one’s overall health, relationships and productivity. Beyond their fundamental role in family support, ABW contribute significantly to the US workforce, education sector, and economy. This three-paper dissertation enhances understanding on PMH outcomes, perception and experiences of ABW in the US. Perinatal depression (PD), one of the most common mood disorders affecting 1 in 8 women, is highlighted. The overarching question is to what extent does the US health system address PMH of ABW …

Identifying Existing Barriers To Equitable Transportation In Birmingham, Alabama, Brandy Rose Mckinney

ETDs from 2020-2029

A transportation system is designed to connect people to essential community resources and support their mobility needs. However, transportation facilities and services in lower-income communities often fail to meet local demands, restricting access to jobs, healthcare, recreation, and other critical services. These gaps disproportionately impact lower-income and vulnerable populations, reducing mobility and overall quality of life. This study aims to (a) define transportation inequity and the measures used to assess it; (b) summarize existing inequities across the United States; (c) examine travel choices, needs, and barriers in lower-income communities in Birmingham, Alabama; and (d) propose strategies to address transportation inequity …

Darkstar: A Memoir In Essays, Sophie Hawke Isham

ETDs from 2020-2029

Darkstar: A Memoir in Essays is an essay collection that follows the last four years of my life. These essays vary in length, format, and material. The themes these essays tackle range from heavy subjects like deteriorating mental health from bipolar disorder and grief over the loss of pets and family members, to lighter subjects such as gender expression and identity, and the love surrounding me from friends, family, and relationships. While each essay can stand alone, they are more fleshed out and connected in the context and structure of this thesis. This body of work explores the various ways …

Behind The Screen: Exploring How Undergraduate Students Experience Sense Of Belonging In Online Learning Environments In The United States, Grace Ellen Kiersznowski

ETDs from 2020-2029

Enrollment in online courses in higher education has been rising rapidly over the past couple of decades and has accelerated since the COVID-19 pandemic. This has made higher learning more accessible for students who would otherwise have difficulty earning a degree. Online education poses many barriers to students’ development of a sense of belonging, something research has been found to be of great importance to student success and well-being. Relatively little was known about students’ sense of belonging in online learning environments prior to the pandemic. Since the pandemic, online education has undergone major changes, changing the landscape in a …

Bone Marrow Adiposity, Obesity, And Tumor Burden In Newly Diagnosed Multiple Myeloma, Ananya Deshpande

ETDs from 2020-2029

Multiple Myeloma (MM) is the second most common hematologic malignancy in the United States. It is characterized by the accumulation of clonally expanded plasma cells in the bone marrow, which leads to end organ damage and myeloma-defining events requiring treatment. The only modifiable risk factor for MM is obesity. However, associations between obesity, bone marrow adipocytes, and tumor burden at MM diagnosis remain unclear. We evaluated associations of bone marrow adipocytes, body mass index (BMI), and clinical features of tumor burden among 168 patients with histologically confirmed newly diagnosed multiple myeloma (NDMM) enrolled in the Integrative Molecular and Genetic Epidemiology …

Caring Through Cancer: The Role Of Stress And Social Support In The Lives Of Caregivers Diagnosed With Cancer, Antoinette Shantay Williams

ETDs from 2020-2029

Caregivers living with cancer face overlapping burdens that are often overlooked in research, policy, and practice, despite the profound implications for their mental health and the care they provide. The main objective of this dissertation is to examine how cancer status, gender, and social support intersect to influence the number of poor mental health days reported by caregivers in the United States and a U.S. territory. Specifically, this study assesses differences in poor mental health days between caregivers with and without cancer and examines whether gender and social support independently and jointly moderate this potential association. Using 2022-2023 data from …

Challenges Of Lutetium-177 Metastable Concentration In Radiopharmaceutical Waste, Cameron Robert Liggitt

ETDs from 2020-2029

Lutetium-177 (Lu-177) is an upcoming radiopharmaceutical with commercial use recently approved for cancer treatment by the Federal Drug Administration (FDA). During production, a contaminate, Lutetium-177 metastable (Lu-177m), can also be produced. The concentration of Lu-177m will vary greatly depending on the production method. One of the largest problems posed by this metastable contaminant is disposal challenges due to its longer half-life and more energetic decay process. This research models the potential for the decay in storage method to be used for disposal of Lu-177 waste based on the concentration of Lu-177m. Utilizing varying ratios of metastable per therapeutic dose, this …

Nazi Propaganda In The United States Prior To American Entry Into The Second World War, Trenton Alexander Bowen

ETDs from 2020-2029

This thesis examines the multifaceted nature of Nazi propaganda in the United States during the interwar years. I argue that these publications were not just a parade of familiar cliches about Jews or the wisdom of American neutrality. Rather, they and the organizations that disseminated them presented a jumbled patchwork of lies, hypocritical claims, contradictions, and distortions. In other words, I argue that Nazi propaganda was so dangerous in the United States because it relied on mixed and confusing messaging, and in turn, on the ignorance of Americans about the nature of the “new Germany.”

Shaping Fibroblast Fate To Drive Fibrotic Remodeling In Pulmonary Fibrosis: Decoding S100a4, Spring Li

ETDs from 2020-2029

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by persistent fibroblast activation, excessive extracellular matrix (ECM) deposition, and irreversible remodeling of lung architecture. A central feature of disease progression is the accumulation of fibroblasts that evade apoptosis and persist in a pathologically activated state. However, the molecular mechanisms that sustain this aberrant phenotype remain incompletely understood. The calcium-binding protein S100A4 has been implicated in fibrotic processes, but its role in orchestrating fibroblast fate and profibrotic behavior has not been fully defined, particularly with respect to its influence on fibroblast survival and activation in IPF. In the first …

The Medicalization Of Rapists In Psychiatry From 2000-2024, Lily Plowden

ETDs from 2020-2029

The process of human problems coming to be defined as medical conditions and thus under the purview of medical professionals is called medicalization. This study examines how psychiatrists medicalize perpetrators of sexual violence, looking particularly at debates around whether to include a new disorder, Paraphilic Coercive Disorder, in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. Using a content analysis of n=102 articles, it finds that discussions of the pathology of sexual violence perpetration were prevalent among psychiatric journals from 2000-2024. Psychiatrists medicalize rapists through three pathways: advocating for a new medical disorder; attributing the cause of sexual …

Investigation Of The Noise Reduction Performance Of A Commercial Active Noise Canceling (Anc) Device, Eli O'Connor

ETDs from 2020-2029

It is estimated that 22 million workers are exposed to potentially damaging noise at work each year. According to Occupational Safety and Health Administration (OSHA), active noise canceling (ANC) devices are generally not adequate to use for hearing protection in an occupation setting. This study examined the noise attenuation of AirPod Pros 3, to investigate how the device performs at different sound levels. AirPods Pros 3 and a CARL mannequin were used for this study. Two dosimeters were placed inside the mannequin’s right and left ear canals. A speaker played pink noise at external ear sound levels of 90, 95, …

Evaluating The Service Life Of A Respirator Cartridge When Exposed To Various Volatile Organic Compounds, Neha Murad Alwani

ETDs from 2020-2029

Inhalation is the most common exposure pathway. With the significant presence of respiratory exposure, respirator cartridges are widely used as personal protective equipment (PPE) to reduce exposure to gases, vapors, and volatile organic compounds (VOCs). This study evaluated the breakthrough time of respirator cartridges under various VOC environments commonly encountered in beauty salons and automotive repair shops. Breakthrough time is the duration a respirator cartridge can provide protection before contaminants can be inhaled and the respirator cartridge is no longer effective. The breakthrough time of three VOCs was examined: acetone, toluene, and m-xylene. Using a custom designed test chamber equipped …

Potential Noise Exposure During Post-Trip Inspection Among Commercial Freight Truck Operators, Makayla Ashley Baker

ETDs from 2020-2029

Noise exposure is one of the most common occupational hazards. Transportation and mate-rial moving occupations reported exposure to noise levels that ranged from moderate (81.4%), loud (15.9%), to very loud (< 0.5%). This study aimed to assess the working noise environment of freight truck operators while completing post-trip inspection. Area noise sampling was performed while freight truck engines were in idle states. A type 2 sound level meter (SLM) was utilized to record noise levels, positioned at rear of the truck cab with the microphone towards the source at a height of 5 feet. The SLM was set up for three noise metrics: Occupational Safety and Health Administration’s (OSHA) permissible exposure limit (PEL) and Hearing Conservation (HC) action level in addition to the American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit value (TLV). 4 trucks were sampled and for each truck, recording duration lasted approximately 15 minutes, reflecting the time spent conducting post inspections. Data collection included the average sound level (Lavg), A-weighted equivalent continuous sound level (LAeq), and maximum A-weighted sound level (LASmax). The measurements were repeated 3 times for each truck and the data were averaged. Lavg was compared to the three respective occupa-tional exposure limits (OELs), assuming a worst-case scenario. Lavg values of each sampling round among four trucks obtained using the OSHA PEL values ranged from 45.1 to 51.4 dB(A), OSHA HC criteria ranged from 37.8 to 51.9 dB(A), and ACGIH TLV values ranged from 55.5 to 67.9 dB(A). The average LAeq of three sampling rounds of the four trucks ranged from 75.4 to 76.9 dB(A) with Truck 3 having the highest average level. The average LASmax of three sampling rounds ranged from 79.3 to 92.0 dB(A), with Truck 3 having the highest average level. Though none of Lavg averages exceeded the respective OELs, Truck 3 under the ACGIH TLV criterion had the highest Lavg at 51.6.9 dB(A), LAeq at 76.9 dB(A), as well as the highest LASmax at 92.0 dB(A). The elevated sound level may be attributed to engine turnover from automated shutoff in prolonged idle states. Further studies need be conducted to investigate other potential factors such as air-brake systems, engine/cab model and age.

Clinical Validation Of Tabpfn-2.5: Zero-Shot Performance, Data-Scarce Robustness, And Distilled Models For Real-Time Clinical Decision Support, Baraa Aljawawdeh

ETDs from 2020-2029

Accurate clinical risk prediction plays an important role in improving patient outcomes, particularly in perioperative settings where early intervention can influence care decisions. Although machine learning has shown promising results using electronic health record (EHR) data, its use in clinical practice is often limited by complex development processes, the need for hyperparameter tuning, and variability in performance across datasets. These challenges are especially relevant in data-scarce clinical settings. This thesis evaluates TabPFN-2.5, a transformer-based tabular foundation model designed to perform classification without dataset-specific training. The model was applied to two real-world perioperative prediction tasks: unplanned care escalation (UCE) following post-anesthesia …

Effects On Households Of A Proposed Anchorage Municipal Sales Tax: 2026 Update, Matthew Berman, Noah Burke

ISER Reports

This is an update to the 2024 study.

Executive Summary A coalition of Anchorage business leaders has proposed a sales tax for the Municipality of Anchorage. The tax would be levied at 3% of taxable expenditures. The proposal would allocate 2/3 of the revenues from the tax (2% of taxable expenditures) allocated to property tax relief, and the remaining one third (one percent of taxable expenditures) set aside to fund a capital improvements program. The tax would be temporary, set to expire after about 8 years. A study led by Nolan Klouda at the University of Alaska Anchorage Center for …

Fibulin-4 Expressed In Metastatic Breast Cancer Is A Target Of Peptide-Based Imaging Probes And Experimental Therapeutics, Alexes C Daquinag, Sukhen C Ghosh, Solmaz Aghaamiri, Stephen M Farmer, Sheng Zhang, Servando Hernandez Vargas, Ashwin K Ramesh, Zhiqiang An, Ali Azhdarinia, Mikhail G Kolonin

The Brown Foundation: Institute of Molecular Medicine

There is a lack of approaches to detect and kill metastatic cells. As an agent for metastasis targeting, a cyclic peptide BLMP6 has been previously characterized. As a step toward translation, we designed AZDye555-labeled BLMP6 and demonstrated its homing to metastases of human MDA-MB-231 cells in mice. We show that 68Ga-radiolabeled BLMP6 can be used for the detection of MDA-MB-231 metastases. We designed a peptide-drug conjugate consisting of monomethyl auristatin E (MMAE) and BLMP6. We show that MMAE-BLMP6 kills MDA-MB-231 cells in cell culture and in vivo. In mouse models of lung metastases, treatment with MMAE-BLMP6 suppressed metastasis growth …

The Minutes Of The Marshall University Staff Council Meeting, June 2026, Marshall University Staff Council

Staff Council Minutes

No abstract provided.

Epidemiology And Ultrasonographic Observations Of Urogenital Schistosomiasis Related Urinary Tract Morbidity In Itilima District, Simiyu Region, Tanzania, Coletha Yohana, Bruno A. Nyundo, Jared S. Bakuza, Peter F. Rambau, Safari M. Kinung’Hi

Tanzania Journal of Science

Chronic infection of urogenital schistosomiasis in humans is a major cause of urinary tract morbidity in endemic areas. However, information on the prevalence of schistosomiasisrelated urinary tract morbidity is lacking in most endemic countries including Tanzania. This study was conducted to determine the prevalence of schistosomiasis-related urinary tract morbidity in schoolchildren and adults in Itilima District. Urine samples from 682 residents were examined for Schistosoma haematobium infection using urine filtration technique. Urinary tract morbidity was examined by ultrasound. The prevalence of S. haematobium infection was 16.4% (112/682) and varied significantly between villages (range 3.2% to 29.5%, χ2 = 48.467, p < 0.001). There was no significant variation of S. haematobium infection between male and female (8.3 % vs 8.1%, χ2 = 0.679, p = 0.410). Majority (93.8%) had light infections (

Rbr Management, Llc V. Eighth Judicial District Court [State Of Nevada], 142 Nev., Adv. Op. 44 (June 18, 2026), Erika Loveland

Nevada Supreme Court Summaries

Emergency medical service providers and ambulances are not "provider[s] of health care" under NRS 41A.017, so claims against them are not professional negligence claims and require no expert affidavit.

Intrathecal (G4c2)149 Delivery In C9orf72-Deficient Mice Yields Mild Motor Dysfunction And Als/Ftd Pathological Hallmarks, Katelyn Russell, Amelia Shahrabi, Suleyman Akerman, Matthew D. Byrne, Jeffrey Rothstein, Davide Trotti, Brigid Jensen, Aaron Haeusler

Farber Institute for Neuroscience Faculty Papers

A repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet existing mouse models incompletely engage spinal regions implicated in disease. Here, an adeno-associated virus encoding (G4C2)149 repeats was delivered via neonatal intrathecal injection, achieving widespread CNS expression with robust spinal cord targeting. This approach was applied to mice with graded loss of endogenous C9orf72 to interrogate both gain- and loss-of-function mechanisms. Longitudinal motor, behavioral, and pathological analyses revealed that repeat expression primarily drives mild, progressive muscle weakness, whereas coordination deficits were largely genotype dependent. Subtle gait abnormalities and hyperactivity …

A Multimodal Artificial Intelligence Model To Guide Use Of Whole-Pelvic Radiation Therapy In Patients With Localized Prostate Cancer: Exploratory Analysis Of Rtog 9413, Mutlay Sayan, Huei-Chung Huang, Erin L. Stewart, Timothy N. Showalter, Adam P. Dicker, George Daniel Grass, Elizabeth M. Gore, Andrew Michael Mcdonald, J. Daniel Pennington, Mark A. Hallman, Igor J. Barani, I-Chow Hsu, Michael Rooney, Stephanie L. Pugh, Paul L. Nguyen, Phuoc T. Tran, Mack Roach Iii

Department of Radiation Oncology Faculty Papers

Background/Objectives: This study explored whether a multimodal artificial intelligence (MMAI) model integrating digitized histopathology and clinical features can identify prostate cancer patients who may benefit from neoadjuvant hormonal therapy (NHT) and whole-pelvic radiotherapy (WPRT). Methods: This secondary analysis of NRG/RTOG 9413 included NHT-treated patients with digitized biopsy slides and clinical data who were not part of the MMAI model optimization. A previously validated MMAI model estimated long-term risk, and Fine-Gray models evaluated interactions between MMAI-derived scores and the radiation field (WPRT vs. prostate-only RT [PORT]) for biochemical failure (BF), chosen over progression-free survival because of extended follow-up and distant metastasis …

Qeith: Quantifies Tumor Ecosystem Heterogeneity To Predict Cancer Progression And Treatment Benefit, Qiqi Liu, Jiangti Luo, Jiawei Wang, Bangqi Zhao, Xiaosheng Wang, Linjun You

Faculty, Staff and Student Publications

Intratumor heterogeneity (ITH) is a fundamental driver of therapeutic failure and disease progression. However, the complexity of the tumor ecosystem is a critical yet underexplored aspect, making its precise quantification essential for fully deciphering ITH and its clinical implications. To address this, we developed Quantifying Ecosystem Intratumor Heterogeneity (QeITH), a computational framework that applies Shannon entropy to quantify ecosystem heterogeneity by measuring the diversity and distributional entropy of cellular compositions and functional states across single-cell, bulk, and spatial transcriptomics. At the single-cell resolution, QeITH identifies elevated ITH as intrinsic markers of malignant transformation, yet enhanced sensitivity to therapy. Pan-cancer bulk …

Library Worker, Heal Thyself? Collaborative Coping Strategies For Those Facing Burnout In Academic Libraries, Michelle Colquitt

Presentations

No abstract provided.

Individual Responsibility And The Limits Of U.S. Dietary Guidelines: Addressing Ultra-Processed Food Consumption Through Structural Policy, Malika Al Kattan, Lynne Alexandra Kennedy

All Works

No abstract provided.

Acute Practitioners’ Experiences Of Implementing Frailty Same Day Emergency Care: A Researcher-In-Residence Study, John Downey, Kieran Green, Sheena Asthana, Joanne Watson

School of Nursing and Midwifery

Introduction: NHS policy promotes Frailty Same Day Emergency Care (F-SDEC) units to alleviate pressure on emergency departments (ED) and improve care for frail people through comprehensive geriatric assessment and same-day discharge. However, evidence remains limited on how such services are implemented in practice, particularly in resource-constrained and geographically peripheral settings. This study aimed to examine how implementation barriers are experienced and negotiated during the day-to-day delivery of an F-SDEC pilot.Methods: Using a Researcher-in-Residence approach, a researcher embedded in a coastal hospital in Torbay, South-West England, collected field notes from prior observations to inform the interview guide, conducted semi-structured interviews with …

Counterfactual Thinking And Aging: The Role Of Executive Function., Clare Walsh, Catherine Deeprose, Raluca A. Briazu, Alison Bacon

School of Psychology

People frequently think about how events in the past might have happened differently and these thoughts play a central role in their cognitive, emotional and social functioning. Our study examined how these processes change with age. A group of 56 younger (mean age 22.34) and 50 older (mean age 71.96) adults completed tasks measuring the spontaneous generation of counterfactual thoughts, the generation of counterfactual thoughts when cued and the Counterfactual Inference Test which taps into the ease with which salient counterfactual thoughts come to mind. They also completed a Counterfactual Seeking Task to measure their motivation to seek out counterfactual …