Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 10291 - 10320 of 1791722

Full-Text Articles in Entire DC Network

Safety Of Concurrent Benzodiazepine Use During Buprenorphine Treatment For Opioid Use Disorder: A Systematic Review Of Real-World Evidence And Risk-Of-Bias Assessment, Abolfazl Sadeghi, Tyler J. Varisco, Parastoo Mousavi Jun 2026

Safety Of Concurrent Benzodiazepine Use During Buprenorphine Treatment For Opioid Use Disorder: A Systematic Review Of Real-World Evidence And Risk-Of-Bias Assessment, Abolfazl Sadeghi, Tyler J. Varisco, Parastoo Mousavi

Posters

Background: Concurrent benzodiazepine (BZD) use among patients receiving buprenorphine for opioid use disorder (OUD) is common in routine care and presents a critical clinical dilemma. While buprenorphine improves survival and reduces overdose risk, co-exposure to central nervous system depressants may increase the risk of adverse events. However, medication-specific real-world evidence remains limited, and existing studies report conflicting findings. Objective: To synthesize real-world observational evidence on safety outcomes associated with concurrent BZD use during buprenorphine treatment and to critically appraise study quality using ROBINS-I V2. Methods: We conducted a critical narrative review following PRISMA guidelines. PubMed/MEDLINE, Embase, and Web of Science …

Go to article

Improving Access To Buprenorphine: A Pilot Multi-Component Pharmacy Intervention, Lyn Yuen Choo, Douglas Thornton, Erin Winstanley, Wanhong Zheng, Jared Lapkowicz, Katie Kang, Sijin Wen Jun 2026

Improving Access To Buprenorphine: A Pilot Multi-Component Pharmacy Intervention, Lyn Yuen Choo, Douglas Thornton, Erin Winstanley, Wanhong Zheng, Jared Lapkowicz, Katie Kang, Sijin Wen

Posters

Background: Patients with opioid use disorder encounter challenges obtaining buprenorphine (BUP) at pharmacies, increasing their risk of treatment non-adherence and illicit drug use.   Objectives: The purpose of this quality improvement (QI) initiative was to implement and evaluate a multi-component intervention to ensure continuous BUP access.   Methods: Using a quasi-experimental study design, the initiative was developed and a convenience sample was recruited from an outpatient BUP treatment program and a pharmacy affiliated with the West Virginia University health system between November 20, 2023, to November 29, 2024. The QI intervention consisted of education for patients, pharmacy and clinic staff, use of …

Go to article

Variation In Estimated Pharmacy Acquisition Costs Relative To Nadac: Evidence From A Multi-State Analysis, Bryan Amick Jun 2026

Variation In Estimated Pharmacy Acquisition Costs Relative To Nadac: Evidence From A Multi-State Analysis, Bryan Amick

Podiums

Background: Survey-based approaches for estimating pharmacy acquisition costs have become increasingly prevalent. While originally developed for Medicaid, these models have expanded and, in some states, have been adopted legislatively as a reimbursement price floor for all payers. The National Average Drug Acquisition Cost (NADAC) is the predominant national benchmark, but several states conduct independent surveys to establish their own Actual Acquisition Cost (AAC) benchmarks. The extent to which these approaches accurately measure pharmacy acquisition cost remains unclear.   Objectives: To evaluate differences between survey-based pharmacy acquisition cost benchmarks, focusing on differences between brand and generic drugs.   Methods: Medicaid drug utilization for …

Go to article

Comparative Effectiveness Of Augmentation, Switching, And Dose Escalation After Inadequate Antidepressant Response In Medicare Beneficiaries, Chih-Ting (Tim) Lai, Jingjing Qian, Cherry Jackson, Kimberly Garza, Jingyi Zheng, Richard Chapman, Surachat Ngorsuraches Jun 2026

Comparative Effectiveness Of Augmentation, Switching, And Dose Escalation After Inadequate Antidepressant Response In Medicare Beneficiaries, Chih-Ting (Tim) Lai, Jingjing Qian, Cherry Jackson, Kimberly Garza, Jingyi Zheng, Richard Chapman, Surachat Ngorsuraches

Podiums

Objective: To evaluate the comparative effectiveness of treatment augmentation, switching, or dose escalation for inadequate treatment response among patients living with depression. Methods: We conducted a retrospective cohort study using data from the Medicare Current Beneficiary Survey(MCBS; 2016-2022). We identified beneficiaries with depression who had both survey responses and had at least one antidepressant claim record 6 months before the outcome assessment. We excluded patients diagnosed with bipolar disorder, schizophrenia, and other psychotic disorders. Patients with evidence of treatment resistance, determined by using 3 or more antidepressants, or any antipsychotics at baseline, were also excluded. The primary outcome was the …

Go to article

Exploring Hpv Vaccine Acceptance And Health Beliefs Among Arab American Parents In The United States: A Qualitative Study Using The Health Belief Model, Nada Alshahrani, Jesus Sanchez, Nancy Shehadeh Jun 2026

Exploring Hpv Vaccine Acceptance And Health Beliefs Among Arab American Parents In The United States: A Qualitative Study Using The Health Belief Model, Nada Alshahrani, Jesus Sanchez, Nancy Shehadeh

Posters

Abstract Background: Arab Americans are a rapidly growing ethnic minority in the United States, but their classification as ‚ÄúWhite‚Äù in federal health data renders them statistically invisible, creating a gap in understanding their preventive health beliefs. Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States and a leading cause of cervical cancer and other cancers. Parental acceptance of the HPV vaccine is crucial for increasing vaccination among children and adolescents. The Health Belief Model (HBM) is commonly used to understand vaccine decision-making; however, its application to Arab American parents remains unexplored. Aim: This study aimed …

Go to article

Adherence Trajectories To Antipsychotic Medications Among South Carolina Medicaid Beneficiaries With Schizophrenia Or Schizoaffective Disorder, Maggie Gu, Chao Cai, Chandana Chidrala, Lauren Wier, Qi Wang, Robert Bank Jun 2026

Adherence Trajectories To Antipsychotic Medications Among South Carolina Medicaid Beneficiaries With Schizophrenia Or Schizoaffective Disorder, Maggie Gu, Chao Cai, Chandana Chidrala, Lauren Wier, Qi Wang, Robert Bank

Posters

Background: Schizophrenia is a chronic mental disorder that requires lifelong treatment. Medication nonadherence contributes to poor medical outcomes; the ability to predict a patient‚Äôs adherence trajectory cannot be understated in forestalling negative effects of nonadherence. This study aims to identify antipsychotic adherence latent classes among patients diagnosed with schizophrenia or schizoaffective disorder and evaluate predictors of adherence latent classes. Healthcare utilization, including hospitalization and emergency department (ED) visits, by latent class were also evaluated.   Methods: This study utilized South Carolina Medicaid claims for beneficiaries diagnosed with schizophrenia or schizoaffective disorder from 2012 to 2020. Eligible patients were observed with baseline …

Go to article

Evaluating The Impact Of Opioid Use In Functional Limitation And Healthcare Utilization Of Arthritic Patients Using Methotrexate In The United States, Oluwafeyisayo Obadimu Jun 2026

Evaluating The Impact Of Opioid Use In Functional Limitation And Healthcare Utilization Of Arthritic Patients Using Methotrexate In The United States, Oluwafeyisayo Obadimu

Podiums

Introduction: Arthritis remains a leading cause of chronic pain, disability, and healthcare expenditure in the United States, affecting over 53-million adults and contributing to economic burden exceeding $580 billion/annum. Despite widespread use, evidence on the impact of chronic opioid therapy on functional outcomes and healthcare utilization is limited. This study evaluates impact of opioid use on functional status and healthcare utilization among arthritis patients using methotrexate. Methods: A retrospective cohort study was conducted using 2018 - 2022 data from the Medical Expenditure Panel Survey. Adults (18 years) with arthritis using methotrexate were categorized into opioid users and non-opioid users. Functional …

Go to article

Geographic Variation In Pharmacist Scope Of Practice For Prep Delivery Across The United States, Gabriel Ezenri, Bita Fayaz Farkhad Jun 2026

Geographic Variation In Pharmacist Scope Of Practice For Prep Delivery Across The United States, Gabriel Ezenri, Bita Fayaz Farkhad

Podiums

Background: Pre-exposure prophylaxis (PrEP) remains substantially underutilized in the United States, with only 25% of eligible individuals receiving it. Community pharmacists represent an accessible setting for care delivery, with nearly 90% of Americans living within five miles of a pharmacy; however, state laws governing pharmacist involvement in PrEP vary substantially. This study characterizes state-level variation in pharmacist scope-of-practice policies for HIV prevention across the United States.   Methods: We conducted a cross-sectional policy surveillance study using the NASTAD Pharmacist Authority Database, state statutes, regulations, and legislative session laws. State laws and regulations were coded across five domains: (1) oral PrEP/PEP prescribing …

Go to article

Expanding Naloxone And Fentanyl Test Strip Awareness And Access In A Rural Community, James Hawkins, Nga-Weng (Ivy) Leong, Sujith Ramachandran, Lyda Stokes, Lindsey Miller, Kristen Pate, Joe Dikun, Marie Barnard, John Bentley Jun 2026

Expanding Naloxone And Fentanyl Test Strip Awareness And Access In A Rural Community, James Hawkins, Nga-Weng (Ivy) Leong, Sujith Ramachandran, Lyda Stokes, Lindsey Miller, Kristen Pate, Joe Dikun, Marie Barnard, John Bentley

Posters

Drug overdose has been a public health crisis and north Mississippi remains a heavily impacted area. Adolescents and young adults, especially college and high school students, have increased exposure to opioids and other drugs, leading to an increased likelihood of fatal and non-fatal drug overdose events. Despite the critical need for awareness among students, there exists significant challenges in current educational and distributional efforts. Objectives: SafeGuardMS is a SAMHSA-funded program with two goals: to deliver overdose-related and harm reduction education to students and to expand access to these life-saving tools among high school and college students in north Mississippi. Methods …

Go to article

Factors Influencing The Masld Risk In Type 2 Diabetes: A Cross-Sectional Study, Asmita Priyadarshini Khatiwada, Surachat Ngorsuraches Jun 2026

Factors Influencing The Masld Risk In Type 2 Diabetes: A Cross-Sectional Study, Asmita Priyadarshini Khatiwada, Surachat Ngorsuraches

Posters

Considering the burden of metabolic dysfunction-associated steatotic liver disease (MASLD) in individuals with type 2 diabetes (T2D), this study aimed to identify factors associated with MASLD among adults with T2D. A retrospective cross-sectional study using data from the 'All of Us' NIH research program from 2021 to 2023 was conducted. MASLD was identified using ICD-9/10 and SNOMED codes. Various factors, including age, gender, race/ethnicity, health insurance, education, employment, household income, comorbidity burden measured by the Charlson Comorbidity Index (CCI), and social determinants of health (SDOH), such as deprivation index by zip code, food insecurity, housing instability, social cohesion, stable housing …

Go to article

Patient Preferences For Pharmacy-Based Contraception Prescribing Services, Abby Davies, Jordan Ballou, Emily Mann, Bryan Love, Chao Cai, Ismaeel Yunusa, Tessa J. Hastings Jun 2026

Patient Preferences For Pharmacy-Based Contraception Prescribing Services, Abby Davies, Jordan Ballou, Emily Mann, Bryan Love, Chao Cai, Ismaeel Yunusa, Tessa J. Hastings

Posters

BACKGROUND: Pharmacist scope of practice in the United States has expanded to include prescribing hormonal contraception in over 30 states and the District of Columbia. Community pharmacies are highly accessible and have the potential to improve access to contraception, particularly in areas with limited reproductive health services. Despite this expansion, utilization of pharmacy-based contraception prescribing remains low. It is unclear whether this is due to lack of patient awareness, lack of interest, or misalignment between available services and patient preferences. Therefore, this study used a discrete choice experiment (DCE) to assess patient preferences for key attributes of pharmacy-based contraception services. …

Go to article

Contemporary Patterns Of Diuretic Utilization Among Pregnant Women With Cardiovascular Conditions In The U.S.: A Population-Based Study, Rupal Aroza, Daniela Moga, Christopher Mclouth, Patricia Freeman, Olufunmilola Abraham, Hend Mansoor Jun 2026

Contemporary Patterns Of Diuretic Utilization Among Pregnant Women With Cardiovascular Conditions In The U.S.: A Population-Based Study, Rupal Aroza, Daniela Moga, Christopher Mclouth, Patricia Freeman, Olufunmilola Abraham, Hend Mansoor

Posters

Background: Diuretics are used to manage hypertension and heart failure; however, the data on their safety during pregnancy are limited. Objective: To examine contemporary trends in diuretic use among pregnant women with cardiovascular conditions in the United States from 2010 to 2023. Methods: We conducted a population-based study using two large U.S. administrative claims databases; Merative MarketScan (commercial) and Medicaid Analytic eXtract (public) from 2010 to 2023. Pregnant women aged 12‚Äì55 were identified using a previously validated pregnancy identification algorithm. We included only women with continuous enrollment from one year before last menstrual period (LMP) date through pregnancy end. Diuretic …

Go to article

Neddylation Maintains Oocyte Quality By Stabilizing Mitochondrial Transcription, Avery A Ahmed, Tessa E Steenwinkel, Bethany K Patton, Peixin Jiang, Matthew D Meyer, Jaspreet K Rishi, Mei Leng, Alexander B Saltzman, Elizabeth S Anaya, Momal Sharif, Laurie J Mckenzie, Laura Detti, Anna Malovannaya, Sean M Hartig, Stephanie A Pangas Jun 2026

Neddylation Maintains Oocyte Quality By Stabilizing Mitochondrial Transcription, Avery A Ahmed, Tessa E Steenwinkel, Bethany K Patton, Peixin Jiang, Matthew D Meyer, Jaspreet K Rishi, Mei Leng, Alexander B Saltzman, Elizabeth S Anaya, Momal Sharif, Laurie J Mckenzie, Laura Detti, Anna Malovannaya, Sean M Hartig, Stephanie A Pangas

Faculty, Staff and Students Publications

Age-related decline in oocyte quality increases the risk of infertility, miscarriage, and birth defects. Mitochondrial dysfunction is a key contributor to this decline. Here, we report that oocyte-specific deletion of Uba3, which encodes the catalytic subunit of the E1 NEDDylation-activating complex, causes sterility in mice. Fully grown, germinal vesicle–stage Uba3 conditional knockout oocytes exhibit mitochondrial dysfunction, including elevated reactive oxygen species, impaired oxidative phosphorylation, and depletion of mitochondrially encoded RNA transcripts. Proteomic analysis identified alterations in mitochondrial-associated proteins, including enrichment of mitochondrial matrix and respiratory chain components and reduced abundance of electron transport chain complexes. These defects were associated …

Go to article

Targeted Inhibition Of Atr Kinase Promotes Antitumor Immunity In Hnscc Through Enhanced Sting Activation And T Cell Function, Fabio Hb Da Costa, Mutsuki Kawabe, Tsung-You Tsai, Kento Okamoto, Mason D Bartels, Sofia Cortes, Ratna Veeramachaneni, Roberto Rangel, Mitchell J Frederick, Vlad C Sandulache, Andrew G Sikora, Jeffrey N Myers, Abdullah A Osman Jun 2026

Targeted Inhibition Of Atr Kinase Promotes Antitumor Immunity In Hnscc Through Enhanced Sting Activation And T Cell Function, Fabio Hb Da Costa, Mutsuki Kawabe, Tsung-You Tsai, Kento Okamoto, Mason D Bartels, Sofia Cortes, Ratna Veeramachaneni, Roberto Rangel, Mitchell J Frederick, Vlad C Sandulache, Andrew G Sikora, Jeffrey N Myers, Abdullah A Osman

Faculty, Staff and Students Publications

Objectives: Oral cavity head and neck squamous cell carcinoma (HNSCC) represents a major global health burden, with over 40,000 new cases annually in the United States and >500,000 worldwide. Despite advances in surgery, radiation therapy, chemotherapy, and immunotherapy, overall survival rates have remained largely stagnant over the past three decades, and over half of patients ultimately die from the disease. Although immune checkpoint inhibitors (ICIs) have improved outcomes for a subset of patients with recurrent or metastatic HNSCC, the majority gain limited benefit. Thus, novel therapeutic strategies that enhance responses to immunotherapy are urgently needed. The ATR-CHK1 signaling pathway has …

Go to article

Conformational Cycling Of The Wntless Transporter Drives Trafficking And Secretion Of Wnt Morphogens, Yunhui Ge, Taciani De Almeida Magalhaes, Hongjiang Wu, Dick J H Van Den Boomen, Thu Uyen Nguyen, Tongyi Dou, Gaya P Yadav, Sukyeong Lee, Zhao Wang, Andrew Lemoff, Xuemei Luo, Sumitha S Menon, Min Zhang, Jin Wang, Zhicheng Jin, Jiansen Jiang, Adrian Salic, Pengxiang Huang Jun 2026

Conformational Cycling Of The Wntless Transporter Drives Trafficking And Secretion Of Wnt Morphogens, Yunhui Ge, Taciani De Almeida Magalhaes, Hongjiang Wu, Dick J H Van Den Boomen, Thu Uyen Nguyen, Tongyi Dou, Gaya P Yadav, Sukyeong Lee, Zhao Wang, Andrew Lemoff, Xuemei Luo, Sumitha S Menon, Min Zhang, Jin Wang, Zhicheng Jin, Jiansen Jiang, Adrian Salic, Pengxiang Huang

Faculty, Staff and Students Publications

Wnt proteins are lipid-modified morphogens fundamental in development and disease. During Wnt biogenesis, the G-protein-coupled receptor (GPCR)-like transporter Wntless (WLS) escorts lipidated Wnts from the endoplasmic reticulum to the plasma membrane, then transfers them to extracellular carriers, forming active and soluble morphogen-carrier complexes. To dissect the mechanisms involved, we solve cryo-EM structures of Wnt-bound WLS and unliganded WLS, and perform structure-guided functional experiments. Wnts engage WLS via three conserved hairpins, which are all required for Wnt trafficking to the cell surface and carrier-mediated secretion. Wnt release from cells is driven by dramatic conformational changes in the WLS transmembrane domain, reminiscent …

Go to article

3d Em Uncovers Mitochondrial Network Remodeling In Residual Triple Negative Breast Cancer After Conventional Chemotherapy Treatments, Mariah J Berner, Heather K Beasley, Benjamin Rodriguez, Audra Lane, Steven W Wall, Andrea G Marshall, Zer Vue, Larry Vang, Mokryun L Baek, Mason Killion, Faben Zeleke, Bryanna Shao, Dominique Parker, Autumn Peterson, Julie Sterling Rhoades, Lacey E Dobrolecki, Amber Crabtree, Annet Kirabo, Sepiso K Masenga, Prasanna Katti, Prasanna Venkhatesh, Chandravanu Dash, Michael T Lewis, Antentor Hinton, Gloria V Echeverria Jun 2026

3d Em Uncovers Mitochondrial Network Remodeling In Residual Triple Negative Breast Cancer After Conventional Chemotherapy Treatments, Mariah J Berner, Heather K Beasley, Benjamin Rodriguez, Audra Lane, Steven W Wall, Andrea G Marshall, Zer Vue, Larry Vang, Mokryun L Baek, Mason Killion, Faben Zeleke, Bryanna Shao, Dominique Parker, Autumn Peterson, Julie Sterling Rhoades, Lacey E Dobrolecki, Amber Crabtree, Annet Kirabo, Sepiso K Masenga, Prasanna Katti, Prasanna Venkhatesh, Chandravanu Dash, Michael T Lewis, Antentor Hinton, Gloria V Echeverria

Faculty, Staff and Students Publications

Mitochondria are hubs of metabolism and signaling. We previously demonstrated the importance of mitochondrial structure and function in chemotherapy-refractory triple-negative breast cancer (TNBC). Herein, we present the first 3D analysis of mitochondrial networks in human tumor tissues. Using serial block face scanning electron microscopy, we reconstructed 3,750 mitochondria and 800 lipid droplets (LDs) in naive and residual tumors persisting after conventional chemotherapies in two orthotopic patient-derived xenografts (PDX). Chemotherapies administered as monotherapy or in combination produced residual tumors that harbored mitochondria with significantly increased areas, volumes, and perimeters. We observed substantial reduction of mitochondrial intratumor heterogeneity following all treatments. Further, …

Go to article

Targeting Arginine Metabolism Overcomes Chemotherapy Resistance In Aggressive-Variant Prostate Cancers, Elavarasan Subramani, Patrick G Pilié, Rebecca Slack-Tidwell, Paul V Viscuse, Xianghong Kuang, Thirukumaran Kandasamy, Dominik Awad, Jenny J Han, Licai Huang, Christine B Peterson, Amado J Zurita, Sumit K Subudhi, Paul G Corn, Rama Soundararajan, Peter Shepherd, Badrajee Piyarathna, Vasanta Putluri, Nagireddy Putluri, Arun Sreekumar, Yuzhuo Wang, Amina Zoubeidi, Iqbal Mahmud, Sara A Martinez, Lin Tan, Philip L Lorenzi, Sreyashi Basu, Sonali Jindal, Padmanee Sharma, Christopher J Logothetis, Timothy C Thompson, Daniel E Frigo, Ana M Aparicio Jun 2026

Targeting Arginine Metabolism Overcomes Chemotherapy Resistance In Aggressive-Variant Prostate Cancers, Elavarasan Subramani, Patrick G Pilié, Rebecca Slack-Tidwell, Paul V Viscuse, Xianghong Kuang, Thirukumaran Kandasamy, Dominik Awad, Jenny J Han, Licai Huang, Christine B Peterson, Amado J Zurita, Sumit K Subudhi, Paul G Corn, Rama Soundararajan, Peter Shepherd, Badrajee Piyarathna, Vasanta Putluri, Nagireddy Putluri, Arun Sreekumar, Yuzhuo Wang, Amina Zoubeidi, Iqbal Mahmud, Sara A Martinez, Lin Tan, Philip L Lorenzi, Sreyashi Basu, Sonali Jindal, Padmanee Sharma, Christopher J Logothetis, Timothy C Thompson, Daniel E Frigo, Ana M Aparicio

Faculty, Staff and Students Publications

Aggressive-variant prostate cancers (AVPCs) respond poorly to anti-androgen therapy but show sensitivity to taxane-platinum chemotherapy, though outcomes remain poor. We conducted a phase 2 trial testing induction cabazitaxel plus carboplatin (CabCarb) followed by olaparib maintenance versus observation in men with AVPC. The primary endpoint of improved progression-free survival (PFS) was not met, likely due to the study being underpowered after 38.5% of patients experienced early progression (ChemoPD) prior to randomization. No genomic alterations predicted ChemoPD; however, transcriptomic analysis revealed the enrichment of metabolic pathways, including arginine metabolism, in ChemoPD tumors. These findings were supported by metabolomics data from preclinical models. …

Go to article

Strategies For Improving The Drug Importation Control System In Thailand: A Qualitative Investigation, Neeranart Potiyanon, Suntaree Watcharadamrongkun Jun 2026

Strategies For Improving The Drug Importation Control System In Thailand: A Qualitative Investigation, Neeranart Potiyanon, Suntaree Watcharadamrongkun

The Thai Journal of Pharmaceutical Sciences

Background: Drug importation plays a critical role in Thailand’s healthcare system; however, barriers affecting its regulatory control and their public health implications remain inadequately examined. This study compared international drug importation procedures and evaluated Thailand’s control system with strategies for improvement.
Methods: Conducted in Bangkok between 2020 and 2023, this two-phase study employed a qualitative design. Phase 1 involved content analysis comparing drug importation procedures across Thailand, Singapore, Australia and the United States to identify best practices and potential solutions. Phase 2 utilized semistructured, in-depth interviews with 19 key informants from government and private-sector agencies. Data collection was guided by …

Go to article

Artificial Intelligence In Hospital Pharmacy Practice: Effectiveness, Internal Validity, And Translational Readiness: A Systematic Review, Kwanchai Rattanamanee, Parnupong Kiewsiri, Prayuth Poowaruttanawiwit Jun 2026

Artificial Intelligence In Hospital Pharmacy Practice: Effectiveness, Internal Validity, And Translational Readiness: A Systematic Review, Kwanchai Rattanamanee, Parnupong Kiewsiri, Prayuth Poowaruttanawiwit

The Thai Journal of Pharmaceutical Sciences

Background: Artificial intelligence (AI) is increasingly integrated into hospital pharmacy, offering potential to enhance medication safety, therapeutic decision-making, and operational efficiency. However, the internal validity and translational readiness of current interventions remain uncertain.
Objectives: The objective of the study was to systematically review AI applications in hospital pharmacy and evaluate their effectiveness, internal validity, and readiness for clinical integration.
Methods: Following Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 guidelines and PROSPERO registration (CRD420251067936), We systematically searched PubMed, Embase, Scopus, Web of Science, IEEE Xplore, and ThaiJO (2000–June 2025). for randomized controlled trials (RCTs), cohort, quasi-experimental, and case–control studies …

Go to article

Assortment Analysis Of Ophthalmic Medicines In The Republic Of Uzbekistan, Zoya Usmonova, Shakhnoz Umarova, Nargiza Sultanbaeva, Marina Taryanikova Jun 2026

Assortment Analysis Of Ophthalmic Medicines In The Republic Of Uzbekistan, Zoya Usmonova, Shakhnoz Umarova, Nargiza Sultanbaeva, Marina Taryanikova

The Thai Journal of Pharmaceutical Sciences

Background: Ophthalmic diseases are a significant public health concern globally and in Uzbekistan, where approximately 1 million individuals are affected.
Objectives: The objectives are to conduct an assortment analysis of ophthalmic medicines registered in Uzbekistan (2010–2024), to identify trends in drug registration, composition, dosage forms, and manufacturing sources.
Materials and Methods: Based on State Register data, medicines classified under Anatomical Therapeutic Chemical S01 were analyzed using marketing and qualimetric methods, focusing on the International Nonproprietary Names, dosage forms, manufacturers, and countries of origin.
Results: The number of registered medicines peaked at 352 in 2022, and then declined to 279 in …

Go to article

Contribution Of Animals To Biomedical Advancements In The Current Era: A Narrative Review, Leena Rajathy Port Louis, Mani Rajarathinam, Prithiviraj Nagarajan, Divya Sekar, Nisha Perumal Jun 2026

Contribution Of Animals To Biomedical Advancements In The Current Era: A Narrative Review, Leena Rajathy Port Louis, Mani Rajarathinam, Prithiviraj Nagarajan, Divya Sekar, Nisha Perumal

The Thai Journal of Pharmaceutical Sciences

Animal research has played a major role in the development of vaccinations and therapies for illnesses such as tetanus, polio, meningitis, hepatitis, and Severe Acute Respiratory Syndrome Coronavirus 2. For every prescription drug available today, animal testing and research have contributed immensely. This narrative review aims to explore the contribution of animals to biomedical advancements in the current era, which involved a search of peer-reviewed literature using electronic databases such as Scopus, Web of Science, and PubMed. In current biomedical research, animals help develop new treatments for long-term illnesses such as cancer, HIV, and Alzheimer’s. Animals also aid in the …

Go to article

Anti-Inflammatory Activities Of Muntingia Calabura L. In Monosodium Urate-Induced Acute Gout Arthritis: Regulation Of Nlrp3 And Il-1Β, Nita Parisa, Eva Rianty, Nia Savitri Tamzil, Debby Handayati Harahap, Veny Larasati, Bintang Arroyantri Prananjaya, Theodorus Theodorus Jun 2026

Anti-Inflammatory Activities Of Muntingia Calabura L. In Monosodium Urate-Induced Acute Gout Arthritis: Regulation Of Nlrp3 And Il-1Β, Nita Parisa, Eva Rianty, Nia Savitri Tamzil, Debby Handayati Harahap, Veny Larasati, Bintang Arroyantri Prananjaya, Theodorus Theodorus

The Thai Journal of Pharmaceutical Sciences

Background: Acute gout arthritis, which is caused by hyperuricemia, is a common inflammatory joint disease, leading to monosodium urate (MSU) crystal deposition. These crystals trigger inflammation, causing pain and significantly impairing the patient’s quality of life. Colchicine is commonly used to treat and prevent acute gout arthritis, but it has several side effects. Cherry tree (Muntingia calabura L.) leaves, which possess anti-inflammatory properties, show promise as an alternative treatment. The potential benefit of the leaves may be due to the flavonoid content.
Objectives: This study aimed to assess the anti-inflammatory activities of cherry tree leaves in an MSU-induced acute …

Go to article

Microwave-Assisted Extraction Optimization And Bioactivity Assessment Of Flavonoid-Rich Extract From Lantana Camara L. Leaves In Zebrafish Epilepsy Model, Prem Kumar B R, Shwetha Krishnamurthy, Gouri Nair, Sundara Saravanan Kamatchi Jun 2026

Microwave-Assisted Extraction Optimization And Bioactivity Assessment Of Flavonoid-Rich Extract From Lantana Camara L. Leaves In Zebrafish Epilepsy Model, Prem Kumar B R, Shwetha Krishnamurthy, Gouri Nair, Sundara Saravanan Kamatchi

The Thai Journal of Pharmaceutical Sciences

Background: Lantana camara L. (Verbanaceae) is known for its bioactive compounds and has been reported for its potential therapeutic applications. Flavonoids from natural sources are acknowledged for their antioxidant and neuroprotective properties, suggesting a possible role in seizure management.
Objectives: This study intended to optimize the microwaveassisted extraction (MAE) of flavonoid-rich extract from L. camara L. leaves utilizing a designof- experiment approach and evaluate its antiepileptic property using the zebrafish model.
Materials and Methods: Four solvents (ethyl acetate, acetone, ethanol, and water) were initially used, with ethanol yielding the highest total flavonoid content (TFC). A central composite design was employed …

Go to article

Samannachan: A Thai Traditional Herbal Recipe With Cytotoxic Potential Against Breast, Cervical, And Ovarian Cancers, Perika Monkanna, Srisopa Ruangnoo, Pakakrong Thongdeeying, Arunporn Itharat, Pranporn Kuropakornpong, Reawfang Sriyom, Apinya Wiboonwattanakit, Kanyarat Namphonsan, Paponpachara Pibanpaknitee, Neal M. Davies Jun 2026

Samannachan: A Thai Traditional Herbal Recipe With Cytotoxic Potential Against Breast, Cervical, And Ovarian Cancers, Perika Monkanna, Srisopa Ruangnoo, Pakakrong Thongdeeying, Arunporn Itharat, Pranporn Kuropakornpong, Reawfang Sriyom, Apinya Wiboonwattanakit, Kanyarat Namphonsan, Paponpachara Pibanpaknitee, Neal M. Davies

The Thai Journal of Pharmaceutical Sciences

Background: Samannachan (SMC) is a Thai traditional herbal recipe that has been used since 2005 at Khampramong Temple, Sakon Nakhon, to treat more than 6,000 cancer patients. However, scientific evidence supporting cytotoxic effects remains limited.
Objectives: The objective of the study is to evaluate the cytotoxicity of the SMC recipe and its ten herbal components against breast, cervical, and ovarian cancer cells compared to normal cells.
Methods: Cytotoxic activity was assessed using the sulforhodamine B (SRB) assay on breast (MCF-7, T47D, MDA-MB-231), cervical (HeLa), and ovarian (SK-OV-3) cancer cell lines, as well as on non-cancerous human keratinocytes (HaCaT). Both aqueous …

Go to article

Using Phenomenology To Investigate Digital Experience: An Empathic-Somatic Approach, Bismark Wiafe Bimpong, William Kesse Bimpong, Mercy Egyir Kwakye Jun 2026

Using Phenomenology To Investigate Digital Experience: An Empathic-Somatic Approach, Bismark Wiafe Bimpong, William Kesse Bimpong, Mercy Egyir Kwakye

Mid-Western Educational Researcher

This conceptual paper proposes the Empathic-Somatic Approach as a methodological contribution for conducting phenomenological research on digital technology experiences. The Empathic-Somatic Approach does not replace existing phenomenological methods but enriches them by operationalizing the insight that we understand others through our own bodies as instruments of empathy. The paper first establishes the essential philosophical and methodological foundations of phenomenology needed to situate this contribution, then develops the Empathic-Somatic Approach in detail, and finally provides practical guidance for its implementation in digital technology research. This approach offers researchers in fields such as human-computer interaction, digital health, and information systems a principled …

Go to article

Parental Attitudes Towards Using Medication To Regulate Behavioral Problems Among Children With Autism Spectrum, Amna Abdulla Alneyadi Jun 2026

Parental Attitudes Towards Using Medication To Regulate Behavioral Problems Among Children With Autism Spectrum, Amna Abdulla Alneyadi

Thesis/ Dissertation Defenses

Medication is increasingly being used to manage behaviour among children with autism spectrum disorder (ASD). However, teachers and parents continue to raise concerns about behavioural problems demonstrated by children with ASD. This raises questions about the efficacy of psychotropic medication used in managing behavioural problems among children with ASD. However, there is limited research on stakeholders’ attitudes towards the usage of medication to manage behavioural problems among children with ASD. The purpose of this study was to examine parents’ attitudes towards using medication to manage behavioural problems among children with ASD. The attitude domain of Ajzen’s theory of planned behaviour …

Go to article

Real-Time Iot-Enabled Dissolved Oxygen Monitoring And Automated Wastewater Recirculation In Constructed Wetlands, Sivasankar Pandiarajan, Vanitha Sankararajan, Devarinti Chandu Jun 2026

Real-Time Iot-Enabled Dissolved Oxygen Monitoring And Automated Wastewater Recirculation In Constructed Wetlands, Sivasankar Pandiarajan, Vanitha Sankararajan, Devarinti Chandu

Mansoura Engineering Journal

Wastewater treatment is necessary for environmental conservation and combating water pollution. This study demonstrates real-time dissolved oxygen (DO) monitoring in constructed wetland treatment. The system would ensure an adequate supply of oxygen through automated water circulation whenever the level is below 4 mg/L, and shut down when it reaches the normal level. From experiments conducted, it was observed that within three automated circulation processes, it is possible to increase DO concentrations from 0.5 mg/L to 5.0 mg/L. Additionally, Total Dissolved Solids reduced from 1,380 ppm to 920 ppm. pH also stabilized from 8.38 to 7.9. In this system, data is …

Go to article

Bridging Machine Learning And Climate Futures: A Framework For Explainable, Self-Directed (Agentic) Ai Models In Monitoring, Mitigation, And Governance Of Anthropogenic Climate Impacts, Vijayanandh Rajamanickam, Ketaki Kulkarni, Vishwanadham Mandala, Ozgur Kisi Jun 2026

Bridging Machine Learning And Climate Futures: A Framework For Explainable, Self-Directed (Agentic) Ai Models In Monitoring, Mitigation, And Governance Of Anthropogenic Climate Impacts, Vijayanandh Rajamanickam, Ketaki Kulkarni, Vishwanadham Mandala, Ozgur Kisi

Mansoura Engineering Journal

Environmental and societal damage due to anthropogenic climate change demands detection and mitigation strategies that are both effective and accountable. Machine Learning (ML) appears to offer a powerful set of tools but remains unexploited in these areas. A key barrier remains its poor ability to draw causal inferences about external systems, an essential requirement for meaningful continued monitoring, acting on, and shaping of the climate. Explainable, self-directed learned models operate by attributing environmental changes and deciding how best to model the resulting dynamics—they offer a natural solution. Recent developments in computational ecology, meteorology, and ML are combined to propose a …

Go to article

When The Weeds Strike Back: Rethinking Aphis's Regulation Of Genetically Engineered Plants Post-National Family Farm Coalition V. Vilsack, Reagan Powers Jun 2026

When The Weeds Strike Back: Rethinking Aphis's Regulation Of Genetically Engineered Plants Post-National Family Farm Coalition V. Vilsack, Reagan Powers

Tennessee Journal of Law and Policy

No abstract provided.

Go to article

False Claims, Real Reforms: Fortifying The Fca In The Face Of Article Ii Scrutiny, Celia Parry, David Chizewer, Roger Lewis Jun 2026

False Claims, Real Reforms: Fortifying The Fca In The Face Of Article Ii Scrutiny, Celia Parry, David Chizewer, Roger Lewis

Tennessee Journal of Law and Policy

No abstract provided.

Go to article

First Prev Next Last