Digital Commons Network^™

Rare Variant Contribution To The Heritability Of Coronary Artery Disease, Alanna C Morrison, Kruthika R Iyer, Erica P Young, Nathan O Stitziel, Goo Jun, Cecelia Laurie, Jai G Broome, Alyna T Khan, Donna K Arnett, Lewis C Becker, Joshua C Bis, Eric Boerwinkle, Donald W Bowden, April P Carson, Patrick T Ellinor, Myriam Fornage, Nora Franceschini, Barry I Freedman, Lifang Hou, Yii-Der Ida Chen, Eimear E Kenny, Charles Kooperberg, Brian G Kral, Ruth J F Loos, Sharon M Lutz, Joann E Manson, Lisa W Martin, Braxton D Mitchell, Rami Nassir, Nicholette D Palmer, Wendy S Post, Michael H Preuss, Bruce M Psaty, Laura M Raffield, Elizabeth A Regan, Stephen S Rich, Jennifer A Smith, Kent D Taylor, Lisa R Yanek, Kendra A Young, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium, Austin T Hilliard, Catherine Tcheandjieu, Patricia A Peyser, Ramachandran S Vasan, Jerome I Rotter, Clint L Miller, Themistocles L Assimes, Paul S De Vries, Ron Do

Faculty, Staff and Student Publications

Whole genome sequences (WGS) enable discovery of rare variants which may contribute to missing heritability of coronary artery disease (CAD). To measure their contribution, we apply the GREML-LDMS-I approach to WGS of 4949 cases and 17,494 controls of European ancestry from the NHLBI TOPMed program. We estimate CAD heritability at 34.3% assuming a prevalence of 8.2%. Ultra-rare (minor allele frequency ≤ 0.1%) variants with low linkage disequilibrium (LD) score contribute ~50% of the heritability. We also investigate CAD heritability enrichment using a diverse set of functional annotations: i) constraint; ii) predicted protein-altering impact; iii) cis-regulatory elements from a cell-specific chromatin …

Deciphering The Local Origins Of Neoliberalism In Central And Eastern Europe: The Example Of Lithuania, Jokubas Salyga

Political Science Faculty Publications

This article studies the local lineage of neoliberalism in Lithuania, examining its intellectual pedigree, early proponents and the structural shifts that facilitated its rise. The latter are attributed to the openings created by perestroika and the development of the communication network linking economists within the Reform Movement of Lithuania, émigré intellectuals and Hillsdale College in Michigan. Information exchanges produced within this network generated embryonic neoliberal ideas before 1991. The network also contributed to the establishment of an influential think tank, the Lithuanian Free Market Institute (LFMI), whose policy influence is illustrated by surveying monetary and pension privatisation reforms.

Philharmonic Orchestra & Chamber Ensembles

Bailey School of Music Concert Programs

Nancy Conley, Conductor

Investigation Of The Acaricidal Efficacy, Tolerance And Residue Levels Of Thymol-Containing Gelatin-Based Hydrogel Developed For Varroosis Control, Onur Demi̇r, Ali̇ Bi̇lgi̇li̇, Mehli̇ka Pulat

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to investigate the acaricidal efficacy, tolerability of the target species and residue levels of a thymol-containing gelatin-based hydrogel developed as a controlled release system for varroosis control. The study was carried out on naturally infested honey bee colonies and compared with those of the negative control and positive control groups. The acaricidal efficacy (%) of the negative control, positive control and hydrogel was 21.93 ± 2.87, 81.09 ± 2.30 and 70.32 ± 2.05, respectively. For the tolerability controls, the average number of dead bees per colony was determined to be 60.80 ± 8.01, 297.40 …

Effects Of Supplementing Rumen-Protected Methionine And Lysine On Milk Yield And Milk Composition In Dairy Cows, Imene Kerbache, Samir Souames, Amel Haddoum, Nedjoua Lakhdara, Nassim Moula

Turkish Journal of Veterinary & Animal Sciences

The use of “health-food additives” has gained significant attention within the dairy sector, with a focus on enhancing the nutritional intake of dairy cows to improve their productivity and reproductive performance. This study aims at examining the impact of rumen-protected methionine (Met) and lysine (Lys) supplementation on production and reproductive parameters in a sample of 100 dairy cows, comprising 32 primiparous and 68 multiparous cows with an average of 5.24±2.31 years. The cows’ average milk production was determined to be 24.9±7.40 kg/day. The cows were divided into two groups, one receiving Met/Lys supplementation and the other serving as a control …

Protocol For Evaluating Anion Exchange Membranes For Nonaqueous Redox Flow Batteries, Jessica L. Tami, Md Motiur R. Mazumder, Grace E. Cook, Shelley D. Minteer, Anne J. Mcneil

Chemistry Faculty Research & Creative Works

Nonaqueous redox flow batteries often suffer from reduced battery lifetime and decreased coulombic efficiency due to crossover of the redox-active species through the membrane. One method to mitigate this undesired crossover is to judiciously choose a membrane based on several criteria: swelling and structural integrity, size and charge of redox active species, and ionic conductivity. Most research to date has focused on reducing crossover by synthesizing modified redox-active molecules and/or new membranes. However, no standard protocol exists to compare membranes and a comprehensive study comparing membranes has yet to be done. To address both these limitations, we evaluate herein 26 …

Pandemic Perspectives From Detained Youth During Covid-19: Bridging The Knowledge Gap For Future Safeguards., April Mcneill-Johnson, Zuri Hudson, Brittany Moore, Dumebi Okocha, Megha Ramaswamy, Kimberly Randell

Manuscripts, Articles, Book Chapters and Other Papers

Despite the worsening health disparities among youth in detention during the COVID-19 pandemic, there has been minimal exploration into the pandemic experiences of detained youth and opportunities for pandemic mitigation. This paper analyzes the perspectives of youth in detention on the pandemic, including the effect of the pandemic on their detention experience and their perceptions about COVID-19 vaccination. The study used purposive sampling to recruit 16 participants (aged 14-17 years) from two juvenile detention centers in the urban Midwest. We conducted semi-structured interviews and analyzed verbatim transcripts using a hybrid deductive-inductive approach and thematic analysis. Four themes emerged: 1) personal …

Spectrum, Volume 53, Issue 5, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Vice Presidential Candidates Debate Ahead of Nov. Election - SHU-Powered Poll Reveals Youth Climate Concerns - A Peek Into Family Weekend Campus - The Statues of Sacred Heart University - New Hub to Stream SHU Sports

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Characterizing The Influence Of Metabolism On Steady State Water Exchange In Yeast As A Potential Mri Diagnostic Biomarker, Samantha Mumford

Dissertations and Theses

Under conditions of ionic equilibrium with the environment a cell maintains a constant volume yet rapidly exchanges water molecules with the extracellular space. The rate constant for steady state water efflux, k_io, can be measured using contrast enhanced magnetic resonance (CE-MR). The active water cycling (AWC) hypothesis is puts forward that k_io is primarily influenced by cellular ATP levels and H⁺ ATPase activity at the cell membrane. Due to the correlation between k_io and ATP levels, k_io is thought to be a probable MRI biomarker for metabolic diseases such as cancer. Yet, the molecular …

Palimbiosis, Leila Walker

Publications and Research

How does one begin to talk about the end? Contemporary artistic and literary responses to climate change frequently invoke Romantic traditions, in part because many theorists attribute our current crisis to historical developments in the Romantic period, but also as means of representing how climate change collapses the familiar orderliness of time. This essay is about the narrative forms that emerge when our place of safety is revealed to be as unstable as melting permafrost. It centers on Mary Shelley’s 1825 essay about a frozen Englishman reanimated during that especially warm summer. I read Shelley’s essay anachronistically alongside contemporary climate …

Symposium: What Does The Microbiome Tell Us About Prevention And Treatment Of Ad/Adrd?, Joia K Capocchi, Claudia Figueroa-Romero, Sage J B Dunham, Gina Faraci, Jason A Rothman, Katrine L Whiteson, Dong-Oh Seo, David M Holtzman, Stefanie Grabrucker, Yvonne M Nolan, Rima Kaddurah-Daouk, David A Jett

2020-Current year OA Pubs

Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota-gut-brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.

Molecular And Clinical Features Of Pancreatic Acinar Cell Carcinoma: A Single-Institution Case Series, Ashwathy Balachandran Pillai, Mahmoud Yousef, Abdelrahman Yousef, Kristin D Alfaro-Munoz, Brandon G Smaglo, Robert A Wolff, Mark W Hurd, Anirban Maitra, Huamin Wang, Matthew Harold G Katz, Laura R Prakash, Ching-Wei D Tzeng, Rebecca Snyder, Luca F Castelnovo, Anthony Chen, Andrey Kravets, Kseniia Kudriavtseva, Artem Tarasov, Kirill Kryukov, Haoqiang Ying, John Paul Shen, Dan Zhao

Faculty, Staff and Student Publications

Objectives: Acinar cell carcinoma (ACC) accounts for about 1% of pancreatic cancers. The molecular and clinical features of ACC are less characterized than those of pancreatic ductal adenocarcinoma. Methods: We retrospectively evaluated the clinical and molecular features of ACC patients who underwent germline and/or somatic molecular testing at The University of Texas MD Anderson Cancer Center from 2008 to 2022 and two cases from 2023-2024 who underwent RNA and TME analysis by Boston Gene. Patient information was extracted from our institutional database with the approval of the Institutional Review Board. Results: We identified 16 patients with available molecular testing …

Phase I/Ii Study Of Bms-986156 With Ipilimumab Or Nivolumab With Or Without Stereotactic Ablative Radiotherapy In Patients With Advanced Solid Malignancies, Joe Y Chang, Xinyan Xu, Girish S Shroff, Nathan I Comeaux, Wei Li, Daniel D Karp, Vivek Verma, Aileen Chen, James Welsh, David S Hong

Faculty, Staff and Student Publications

Background: BMS-986156 is an agonist of the glucocorticoid-induced tumor necrosis factor receptor (TNFR)-related protein (GITR) and promotes increased effector T-cell activation. Combined anti-GITR, anti-programmed death-1, anti-cytotoxic T-lymphocyte-associated protein 4 antibodies and radiotherapy improve tumor control in preclinical studies. Herein we describe the results of the safety and efficacy of BMS-986156+ipilimumab or nivolumab with/without stereotactic ablative radiotherapy (SABR) in patients with advanced solid cancers (NCT04021043).

Methods: This open-label, multigroup, single-center phase I/II study enrolled patients with histologically-confirmed stage IV solid cancers resistant to standard treatments. Group 1 (G1, n=20) received four cycles of ipilimumab (3 mg/kg) plus BMS-986156 (30 …

Status Epilepticus A Risk Factor For Sudden Unexpected Death In Epilepsy (Sudep): A Scoping Review And Narrative Synthesis, Rohit Shankar, Zygimantas Puras, Saffron Richardson, Lance Watkins

Peninsula Medical School

Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a leading cause of mortality among people withepilepsy (PWE). Risk factors such as increased seizure frequency, drug-resistant epilepsy, and early epilepsy onsetare well recognised. However, little evidence of the role of seizure severity, specifically Status Epilepticus (SE) onSUDEP risk exists.Objective: To identify mechanisms, risk factors and clinical characteristics overlap between SE and SUDEP.Methods: A scoping review using the PRISMA-ScR model was performed by two reviewers using suitable searchterms. The PubMed Advanced Search tool along with the ancestry method was utilised to identify suitable articles published between 06/1992 and 05/2023. Quantitative, qualitative and …

Tolkien And The Kalevala (2024) By Jyrki Korpua, Translated By Sonja Virta, Verlyn Flieger

Journal of Tolkien Research

Book review, by Verlyn Flieger, of Tolkien and the Kalevala (2024) by Jyrki Korpua.

Vol. 28, No. 12 - Whole No. 138, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 28, No. 11 - Whole No. 137, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 28, No. 10 - Whole No. 136, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 28, No. 9 - Whole No. 135, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 28, No. 8 - Whole No. 134, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 28, No. 7 - Whole No. 133, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 28, No. 6 - Whole No. 132, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 28, No. 5 - Whole No. 131, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 28, No. 4 - Whole No. 130, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 28, No. 3 - Whole No. 129, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 28, No. 2 - Whole No. 128, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 28, No. 1 - Whole No. 127, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Post-Pandemic Predictors Of Anxiety In College Students, Lisa J. Hayes, R. Brooke Bays, Piper Lashley, Nia Kherani, Alex Swanson

Journal of Applied Disciplines

Rates of anxiety among college students have increased significantly during the COVID-19 pandemic and have remained high (Elharake et al., 2023), placing students at risk for diminished academic performance, depression, and academic burnout (Rassaby et al., 2022). The goal of this study was to examine possible predictors of anxiety in a diverse group of undergraduate students post-pandemic, with the goal of informing future preventive intervention efforts. Maladaptive perfectionism, passive procrastination, active procrastination, cognitive flexibility, and social well-being were assessed as potential predictors of state and trait anxiety in a sample of 297 currently enrolled college students. Results showed that perfectionism …

Community Of Practice Mentoring To Retain Middle School Teachers, Karen Weller Swanson, Micki M. Caskey

Current Issues in Middle Level Education

The purpose of this article is to describe and explain a mentoring initiative for supporting and retaining middle school teachers. First, we examine the persistent problem of teacher retention in U.S. schools, particularly in middle schools. Then, we describe a mentoring initiative—a community practice mentoring model that is well-suited for facilitating professional learning and addressing the retention issue. We define community of practice and note how communities of practices work in schools. We argue that a community of practice model is both a powerful conceptual framework for mentoring teachers and a practical approach to supporting middle school teachers’ practice. Next, …