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Articles 78841 - 78870 of 1455195
Full-Text Articles in Entire DC Network
The Lumberjack, October 23, 2024
The Lumberjack, October 23, 2024
Cal Poly Humboldt's Student Newspaper
The student newspaper of Humboldt State University.
How Can We Improve Educational Experiences For Refugee Students In Poland?, Iwona B. Franczak, Amy C. Lutz
How Can We Improve Educational Experiences For Refugee Students In Poland?, Iwona B. Franczak, Amy C. Lutz
Center for Policy Research
Schools play an important role in safety and stability for refugee students, including the Ukrainian school-age children who fled the war after Russia’s invasion in 2022. This brief summarizes findings from a study that used data from 24 interviews conducted in 2022 with teachers and mothers of Ukrainian refugee children attending elementary schools in Poland to examine the impact of forced migration on academic progress and socio-emotional well-being of refugee students. The authors find war and forced migration disrupt children’s school routines, but that schools can foster positive outcomes by teaching in the children’s native language, using cultural assistants, and …
Gender Ideology And Gender Equality Policy Adoption, Wendell Christopher Lewis
Gender Ideology And Gender Equality Policy Adoption, Wendell Christopher Lewis
Walden Dissertations and Doctoral Studies
Gender-based violence threatens the social and economic security of countries. Gender equality policies, which address the ideological and material relations of gender equality that support gender-based violence, are being stymied by antigender coalitions. Little is known of the concept called gender ideology used by this coalition to facilitate policy intractability of gender equality policies. This mixed-method study was intended to fill the theoretical and methodological gaps in the literature using the narrative policy framework to explore the concept of gender ideology and policy intractability during the National Gender Policy debate in Trinidad and Tobago between 2010-2018. The research questions focused …
Mutual Recognitions Across Generations, Steven L. Winter Walter S. Gibbs Distinguished Professor Of Constitutional Law
Mutual Recognitions Across Generations, Steven L. Winter Walter S. Gibbs Distinguished Professor Of Constitutional Law
Law Faculty Research Publications
“Sovereignty,” Arendt says, “is contradictory to” the human condition. It is not, in any event, the kind of thing that can be shared across generations. Subsequent generations lack sovereignty to the precise degree that they are bound by the decisions of their predecessors. It is no answer to say that contemporary citizens participate in the sovereignty of a whole, transgenerational people. To paraphrase de Tocqueville, later generations are not free because they are not entirely equal, and they are not equal because they are not entirely free.
Where “sovereignty” is a metaphysical concept that transcends time, recognition is an act …
Professional Development: A Mixed Methods Study Of Masters Of Public Health Alumni, Orna Baron-Epel, Yana Douvdevany, Dana Ivancovsky-Wajcman, Paul Barach, Osnat Bashkin, Katarzyna Czabanowska, Keren Dopelt, Nadav Davidovitch, Szczepan Jakubowski, Fiona Macleod, Maureen Malowany, Leah Okenwa-Emegwa, Maya Peled-Raz, Shira Zelber-Sagi
Professional Development: A Mixed Methods Study Of Masters Of Public Health Alumni, Orna Baron-Epel, Yana Douvdevany, Dana Ivancovsky-Wajcman, Paul Barach, Osnat Bashkin, Katarzyna Czabanowska, Keren Dopelt, Nadav Davidovitch, Szczepan Jakubowski, Fiona Macleod, Maureen Malowany, Leah Okenwa-Emegwa, Maya Peled-Raz, Shira Zelber-Sagi
College of Population Health Faculty Papers
INTRODUCTION: We examined the perceptions of the Master of Public Health (MPH) degree graduates regarding their personal competencies, job performance and professional development using a mixed method, explanatory sequential design.
METHODS: A cross-sectional, self-administered questionnaire of the Haifa School of Public Health alumni who graduated between 2005 and 2022 was disseminated to 849 graduates between March and June 2022, from which 127 responded (response rate: 14.90%). This was followed by 24 in-depth interviews with alumni from the same sample (conducted between November 2022 and March 2023).
RESULTS: The sample included 74.8% of females with a mean age of 40.7 years, …
The Parthenon, October 23, 2024, Evan Green, Sarah Davis, Baylee Parsons, Joseph Dicristofaro, Kaitlyn Fleming, Scott Price, Abigail Cutlip, Rafael Alfonso, Wade Sullivan
The Parthenon, October 23, 2024, Evan Green, Sarah Davis, Baylee Parsons, Joseph Dicristofaro, Kaitlyn Fleming, Scott Price, Abigail Cutlip, Rafael Alfonso, Wade Sullivan
The Parthenon
No abstract provided.
2021-2023 Lender Center Symposium | “Access To Wellness For Women In A Diverse Socio-Economic Neighborhood” -- Event Information, Lender Center For Social Justice
2021-2023 Lender Center Symposium | “Access To Wellness For Women In A Diverse Socio-Economic Neighborhood” -- Event Information, Lender Center For Social Justice
The Lender Center for Social Justice
A brief description of the 2021-2023 Lender Center Symposium | “Access to Wellness for Women in a Diverse Socio-Economic Neighborhood” event.
How To Make A Theologian: Theological Education And The Life Of Discipleship, Andrew C. Stout
How To Make A Theologian: Theological Education And The Life Of Discipleship, Andrew C. Stout
The Christian Librarian
No abstract provided.
Relocating Justice, Ruhan Sidhu Nagra
Relocating Justice, Ruhan Sidhu Nagra
Duke Law Journal
Managed retreat—the planned relocation of people facing imminent climate threats—is an inevitable part of future climate adaptation in the United States. Given that Black, Brown, and low-income communities are disproportionately vulnerable to climate hazards, managed retreat has significant justice implications. This Article explores what I call an apparent “justice paradox”—two “justice problems” with managed retreat that seem to point to opposite solutions. On the one hand, managed retreat can be inaccessible to marginalized communities, many of whom lack the resources to successfully navigate the relocation process. This justice problem suggests that decision-makers should prioritize managed retreat for marginalized communities since …
Efficacy Of An Online Mindfulness Training For Adolescents: A Pilot Study, Gus C. Salazar
Efficacy Of An Online Mindfulness Training For Adolescents: A Pilot Study, Gus C. Salazar
Theses and Dissertations
Background: Adolescence represents a period in a person’s life where they develop skills and competencies necessary to flourish in the physical, social, emotional, and academic areas of their lives. Additionally, adolescents are facing unprecedented social and mental health challenges. As such, it is important to equip adolescents with tools to help them succeed. Mindfulness is one resource which has been shown to improve symptoms of stress, depression, and anxiety, while also improving mindfulness ability and overall well-being. Aims: The purpose of this study was to conduct a pilot study to examine the efficacy of a self-guided, internet-delivered mindfulness training with …
Winonan, Winona State University
Winonan, Winona State University
The Winonan - 2020s
This issue of the Winonan, the Winona State University student newspaper, was published on October 23, 2024.
Actuation And Stabilization Of Volume-Efficient Origami-Inspired Mechanisms, Hunter T. Pruett
Actuation And Stabilization Of Volume-Efficient Origami-Inspired Mechanisms, Hunter T. Pruett
Theses and Dissertations
Trends in the aerospace industry are driving payloads to be smaller and less expensive while yet delivering comparatively large antennas. Deployable reflectarray antennas (RA) are the object of much research to meet these demands because they operate in a flat plane and are easier to stow than parabolic reflector antennas. Because they operate in flat plane, deployable RAs are well-suited to thickness-accommodated origami-inspired mechanisms. This work addresses pattern selection and modification, thickness accommodation, actuation, and stabilization of origami-inspired mechanisms intended to be used as RAs. First, a modified Miura-ori pattern termed volume-efficient Miura-ori (VEMO) is introduced, selected for its ability …
Personalized Copd Care: The Future Of Precision-Based Therapies
Personalized Copd Care: The Future Of Precision-Based Therapies
Faculty, Staff and Students Publications
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory illness characterized by long-standing respiratory symptoms and airflow limitation. It is a major contributor to respiratory disease-related deaths and currently ranked as the sixth leading cause of mortality in the United States. Approved pharmacological therapies for the stable disease primarily consist of inhaled short and long-acting bronchodilators, inhaled corticosteroids, azithromycin, and roflumilast. In recent years, significant progress has been made in the management of COPD through the identification of different COPD phenotypes and endotypes, which allows for a more personalized treatment approach. While earlier studies investigating targeted therapies were less promising, …
Construction And Characterization Of Dna Libraries From Cultured Phages And Environmental Viromes, Lorna Min, Anthony W Maresso
Construction And Characterization Of Dna Libraries From Cultured Phages And Environmental Viromes, Lorna Min, Anthony W Maresso
Faculty, Staff and Students Publications
Despite many efforts to understand and leverage the functional potential of environmental viromes, most bacteriophage genes are largely uncharacterized. To explore novel biology from uncultivated microbes like phages, metagenomics has emerged as a powerful tool to directly mine new genes without the need to culture the diverse microbiota and the viruses within. When a pure computational approach cannot infer gene function, it may be necessary to create a DNA library from environmental genomic DNA, followed by the screening of that library for a particular function. However, these screens are often initiated without a metagenomic analysis of the completed DNA library …
Feasibility Of The Mind+Soul Culturally Tailored Brain Healthy Diet: A Pilot Study, Eric D Vidoni, Mickeal N Key, Jannette Berkley-Patton, Jeffrey M Burns
Feasibility Of The Mind+Soul Culturally Tailored Brain Healthy Diet: A Pilot Study, Eric D Vidoni, Mickeal N Key, Jannette Berkley-Patton, Jeffrey M Burns
Faculty, Staff and Student Publications
Alzheimer’s disease (AD) disproportionately impacts Black Americans, who are three times more likely to develop AD. While heart-healthy diets have shown potential in reducing AD risk, research on adapted dietary interventions for Black American communities remains limited. This pilot study assessed the feasibility and acceptability of an adapted brain healthy diet intervention (MIND + SOUL) and explored changes in cardiometabolic risk and cognition. Twenty-nine participants completed the 12-week intervention, which included culturally tailored health education, cooking classes, health coaching, and groceries. Feasibility was assessed by attendance and retention rates, while acceptability was measured by two questionnaires. Participants had a mean …
Beyond The Battlefield: The Social And Legal Status Of Women In Sparta, Kiera Clark
Beyond The Battlefield: The Social And Legal Status Of Women In Sparta, Kiera Clark
Armstrong Undergraduate Journal of History
The social and legal status of women in Sparta differed from other ancient societies, as they were afforded more social mobility and rights to ownership of property than their counterparts in places such as Athens. While other ancient Greek societies secluded women in the home, women in Sparta were educated publicly and able to move freely in public. However, it is important to note that there is limited material and textual evidence from Sparta, which leaves much up to interpretation and requires scholars to make assumptions based on the practices of other Greek societies. Further, the majority of sources regarding …
The Rise And Fall Of Caribbean Piracy: A Socio-Technical Analysis Of The War Of Spanish Succession, Maritime Innovation, And Edward Randolf’S Policy, Dominique M. Salinski
The Rise And Fall Of Caribbean Piracy: A Socio-Technical Analysis Of The War Of Spanish Succession, Maritime Innovation, And Edward Randolf’S Policy, Dominique M. Salinski
Armstrong Undergraduate Journal of History
This paper argues that the mode and historical context in which piracy ascended in the Caribbean after the War of the Spanish Succession, as well as the historical interrelation between maritime technology and pirate tactics, coalesced into a diachronic Damocles Sword that resulted in the downfall of piracy in the Golden Age. Sanctioning piratical enterprises as a subconventional maritime strategy displayed a geopolitical reliance on piracy by great powers. However, the depraved treatment conventional sailors received across all major European navies generated a social stratum that eventually bore the Golden Age of Piracy, while simultaneously contributing significantly to British naval …
The Growing Divide Between Teaching Empathy And Being Empathetic
The Growing Divide Between Teaching Empathy And Being Empathetic
Faculty, Staff and Students Publications
No abstract provided.
Phenormgpt: A Framework For Extraction And Normalization Of Key Medical Findings
Phenormgpt: A Framework For Extraction And Normalization Of Key Medical Findings
Faculty, Staff and Student Publications
This manuscript presents PheNormGPT, a framework for extraction and normalization of key findings in clinical text. PheNormGPT relies on an innovative approach, leveraging large language models to extract key findings and phenotypic data in unstructured clinical text and map them to Human Phenotype Ontology concepts. It utilizes OpenAI's GPT-3.5 Turbo and GPT-4 models with fine-tuning and few-shot learning strategies, including a novel few-shot learning strategy for custom-tailored few-shot example selection per request. PheNormGPT was evaluated in the BioCreative VIII Track 3: Genetic Phenotype Extraction from Dysmorphology Physical Examination Entries shared task. PheNormGPT achieved an F1 score of 0.82 for standard …
Synthesis Of Neuronal Network Dynamics For Optimal Stimulus Encoding And Retention, Bethanna Thompson
Synthesis Of Neuronal Network Dynamics For Optimal Stimulus Encoding And Retention, Bethanna Thompson
McKelvey School of Engineering Graduate Student Theses & Dissertations
A central goal in neuroscience is to understand the relationship between the structure and activity of the brain and the resulting experience of thought and behavior that the brain underpins. Within this goal is the specific study of working memory: the process of storing, managing, and integrating incoming sensory information in the context of ongoing tasks. The process of working memory is foundational to higher cognition and reasoning, determining how we comprehend and interact with the world around us. The neural circuits responsible for working memory are seemingly able to store and process afferent stimuli with other recent or relevant …
Synthesis Of Neuronal Network Dynamics For Optimal Stimulus Encoding And Retention, Bethanna Thompson
Synthesis Of Neuronal Network Dynamics For Optimal Stimulus Encoding And Retention, Bethanna Thompson
McKelvey School of Engineering Graduate Student Theses & Dissertations
A central goal in neuroscience is to understand the relationship between the structure and activity of the brain and the resulting experience of thought and behavior that the brain underpins. Within this goal is the specific study of working memory: the process of storing, managing, and integrating incoming sensory information in the context of ongoing tasks. The process of working memory is foundational to higher cognition and reasoning, determining how we comprehend and interact with the world around us. The neural circuits responsible for working memory are seemingly able to store and process afferent stimuli with other recent or relevant …
Social Stigma And Vulnerabilities Of Women Living With Hiv/Aids In Kyrgyzstan: Service Providers’ Perspectives, Saltanat Childress, Nibedita Shrestha, Eusebius Small, Philip Kreniske, Louisa Gilbert, Aibek Mukambetov, Fred Ssewamala, Ozge Sensoy Bahar, Mary Mckay
Social Stigma And Vulnerabilities Of Women Living With Hiv/Aids In Kyrgyzstan: Service Providers’ Perspectives, Saltanat Childress, Nibedita Shrestha, Eusebius Small, Philip Kreniske, Louisa Gilbert, Aibek Mukambetov, Fred Ssewamala, Ozge Sensoy Bahar, Mary Mckay
SAGE Open Access Agreement Publications-Archive
In Kyrgyzstan, registered HIV cases doubled from 2013 to 2019, with women constituting 39% of cases in 2021. Women living with HIV (WLHIV) encounter heightened intimate partner violence, stigma, and discrimination. This study explores the experiences and vulnerabilities of WLHIV in Kyrgyzstan from the perspective of professionals engaged in HIV care and advocacy. Data from in-depth, semi-structured interviews with 10 professionals engaged in HIV prevention were analyzed using grounded theory methods. The analysis revealed two primary categories related to the experiences of WLHIV as observed by professionals in the field: (a) Challenges faced by WLHIV at the personal, interpersonal, community, …
Spectrum, Volume 53, Issue 6, Sacred Heart University
Spectrum, Volume 53, Issue 6, Sacred Heart University
Newspapers (Obelisk & Spectrum)
Highlights include: SHU Receives $3 Million Grant for Education Program - ZTA Thinks Pink - SHU “Thrive(s) Together” at First Annual Event - WGSS Program Advances SHU’s Course Offerings - Puck Drops on New Season for Women’s Ice Hockey - Women’s Bowling Finishes Second in First Tournament
The True Legacy Of Stono: How The Stono Rebellion Of 1739 Changed South Carolina, David S. Wilkie
The True Legacy Of Stono: How The Stono Rebellion Of 1739 Changed South Carolina, David S. Wilkie
Armstrong Undergraduate Journal of History
Most of the research surrounding South Carolina’s Stono Slave Rebellion revolves around the planning and execution of the rebellion, the motivation of the slaves that chose to participate in the rebellion, and the immediate response of white slaveowners to the rebellion. Conversely, my research focuses on the long-term impact of the rebellion on the institution of slavery in South Carolina. Over the course of my research, I have explored the impact that the rebellion had on South Carolina slaveholders and lawmakers. I argue that the Stono Rebellion generated a fear response among whites in South Carolina that led to the …
The Alzheimer's Disease Neuroimaging Initiative-4 (Adni-4) Engagement Core: A Culturally Informed, Community-Engaged Research (Ci-Cer) Model To Advance Brain Health Equity, Mónica Rivera Mindt, Alyssa Arentoft, Amanda T. Calcetas, Vanessa A. Guzman, Hannatu Amaza, Adeyinka Ajayi, Miriam T. Ashford, Omobolanle Ayo, Lisa L. Barnes, Gladys Maestre
The Alzheimer's Disease Neuroimaging Initiative-4 (Adni-4) Engagement Core: A Culturally Informed, Community-Engaged Research (Ci-Cer) Model To Advance Brain Health Equity, Mónica Rivera Mindt, Alyssa Arentoft, Amanda T. Calcetas, Vanessa A. Guzman, Hannatu Amaza, Adeyinka Ajayi, Miriam T. Ashford, Omobolanle Ayo, Lisa L. Barnes, Gladys Maestre
School of Medicine Publications
Introduction: The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core was launched to advance Alzheimer's disease (AD) and AD-related dementia (ADRD) health equity research in underrepresented populations (URPs). We describe our evidence-based, scalable culturally informed, community-engaged research (CI-CER) model and demonstrate its preliminary success in increasing URP enrollment.
Methods: URPs include ethnoculturally minoritized, lower education (≤ 12 years), and rural populations. The CI-CER model includes: (1) culturally informed methodology (e.g., less restrictive inclusion/exclusion criteria, sociocultural measures, financial compensation, results disclosure, Spanish Language Capacity Workgroup) and (2) inclusive engagement methods (e.g., the Engagement Core team; Hub Sites; Community-Science Partnership Board).
Results: As …
A Look Inside: A Multiple-Case Study Of Schools That Specialize In Dyslexia, Mitzi Berryhill
A Look Inside: A Multiple-Case Study Of Schools That Specialize In Dyslexia, Mitzi Berryhill
LSU Doctoral Dissertations
Dyslexia is a reading disability that heavily affects a student’s phonological processing and ability to decode. Because of the high prevalence of dyslexia, it is important that educators understand dyslexia. By looking inside three specialized schools, this research study sought to understand how students with dyslexia can be supported in an educational setting.
This qualitative, multiple-case research analyzed three specialized schools through questionnaires, interviews, observations, and curriculum and instructional materials. Understanding how a community of practice at each school was envisioned offered much insight into the unique supports in each school as well as similar themes that were found across …
Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis And Regulates A Schizophrenia Susceptibility Gene Network Within The Mouse Dentate Gyrus, Prithviraj Rajebhosale, Alice Jone, Kory R Johnson, Rohan Hofland, Camille Palarpalar, Lorna W Role
Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis And Regulates A Schizophrenia Susceptibility Gene Network Within The Mouse Dentate Gyrus, Prithviraj Rajebhosale, Alice Jone, Kory R Johnson, Rohan Hofland, Camille Palarpalar, Lorna W Role
Faculty, Staff and Student Publications
Neuregulin1 (Nrg1) signaling is critical for neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bidirectional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: (1) local axonal PI3K-AKT signaling and (2) cleavage by γ-secretase resulting in cytosolic release of the intracellular domain (ICD), which can traffic to the nucleus (Bao et al., 2003; Hancock et al., 2008). To dissect the contribution of these alternate signaling strategies to neuronal development, we generated a transgenic mouse with a missense mutation (V
Therapeutic Approaches To Modulate The Immune Microenvironment In Gliomas, Andreas Sarantopoulos, Chibawanye Ene, Elisa Aquilanti
Therapeutic Approaches To Modulate The Immune Microenvironment In Gliomas, Andreas Sarantopoulos, Chibawanye Ene, Elisa Aquilanti
Faculty, Staff and Student Publications
Immunomodulatory therapies, including immune checkpoint inhibitors, have drastically changed outcomes for certain cancer types over the last decade. Gliomas are among the cancers that have seem limited benefit from these agents, with most trials yielding negative results. The unique composition of the glioma immune microenvironment is among the culprits for this lack of efficacy. In recent years, several efforts have been made to improve understanding of the glioma immune microenvironment, aiming to pave the way for novel therapeutic interventions. In this review, we discuss some of the main components of the glioma immune microenvironment, including macrophages, myeloid-derived suppressor cells, neutrophils …
Impact Of Select Actionable Genomic Alterations On Efficacy Of Neoadjuvant Immunotherapy In Resectable Non-Small Cell Lung Cancer, Nicolas Zhou, Cheuk H Leung, William N William, Annikka Weissferdt, Apar Pataer, Brett W Carter, Anne S Tsao, George R Blumenschein, Xiuning Le, Jianjun Zhang, Ferdinandos Skoulidis, Jonathan M Kurie, Mehmet Altan, Charles Lu, Bonnie S Glisson, Lauren A Byers, Yasir Y Elamin, Reza J Mehran, David C Rice, Garrett L Walsh, Wayne L Hofstetter, Jack A Roth, Hai T Tran, Jia Wu, Luisa M Solis Soto, Humam Kadara, Stephen G Swisher, Ara A Vaporciyan, Don L Gibbons, Heather Y Lin, J Jack Lee, John V Heymach, Marcelo V Negrao, Boris Sepesi, Tina Cascone
Impact Of Select Actionable Genomic Alterations On Efficacy Of Neoadjuvant Immunotherapy In Resectable Non-Small Cell Lung Cancer, Nicolas Zhou, Cheuk H Leung, William N William, Annikka Weissferdt, Apar Pataer, Brett W Carter, Anne S Tsao, George R Blumenschein, Xiuning Le, Jianjun Zhang, Ferdinandos Skoulidis, Jonathan M Kurie, Mehmet Altan, Charles Lu, Bonnie S Glisson, Lauren A Byers, Yasir Y Elamin, Reza J Mehran, David C Rice, Garrett L Walsh, Wayne L Hofstetter, Jack A Roth, Hai T Tran, Jia Wu, Luisa M Solis Soto, Humam Kadara, Stephen G Swisher, Ara A Vaporciyan, Don L Gibbons, Heather Y Lin, J Jack Lee, John V Heymach, Marcelo V Negrao, Boris Sepesi, Tina Cascone
Faculty, Staff and Student Publications
Background: Neoadjuvant immune checkpoint inhibitors (ICIs) have improved survival outcomes compared with chemotherapy in resectable non-small cell lung cancer (NSCLC). However, the impact of actionable genomic alterations (AGAs) on the efficacy of neoadjuvant ICIs remains unclear. We report the influence of AGAs on treatment failure (TF) in patients with resectable NSCLC treated with neoadjuvant ICIs.
Methods: Tumor molecular profiles were obtained from patients with stage I-IIIA resectable NSCLC (American Joint Committee on Cancer seventh edition) treated with either neoadjuvant nivolumab (N, n=23) or nivolumab+ipilimumab (NI, n=21) followed by surgery in a previously reported phase-2 randomized study (NCT03158129). TF …
The Dleu2/Mir-15a/Mir-16-1 Cluster Shapes The Immune Microenvironment Of Chronic Lymphocytic Leukemia, Ronghua Zhang, Priyanka Khare, Priyanka Banerjee, Cristina Ivan, Sarah Schneider, Karen Clise-Dwyer, Erika Thompson, Marisela Mendoza, Nicholas Chiorazzi, Shih-Shih Chen, Xiao-Jie Joy Yan, Nitin Jain, Paolo Ghia, Federico Caligaris-Cappio, Rima Mendonsa, Sashi Kasimsetty, Ryan Swoboda, Recep Bayraktar, William Wierda, Varsha Gandhi, George A Calin, Michael J Keating, Maria Teresa Sabrina Bertilaccio
The Dleu2/Mir-15a/Mir-16-1 Cluster Shapes The Immune Microenvironment Of Chronic Lymphocytic Leukemia, Ronghua Zhang, Priyanka Khare, Priyanka Banerjee, Cristina Ivan, Sarah Schneider, Karen Clise-Dwyer, Erika Thompson, Marisela Mendoza, Nicholas Chiorazzi, Shih-Shih Chen, Xiao-Jie Joy Yan, Nitin Jain, Paolo Ghia, Federico Caligaris-Cappio, Rima Mendonsa, Sashi Kasimsetty, Ryan Swoboda, Recep Bayraktar, William Wierda, Varsha Gandhi, George A Calin, Michael J Keating, Maria Teresa Sabrina Bertilaccio
Faculty, Staff and Student Publications
The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities and on the immunosuppressive microenvironment. We have explored the possibility that genetic drivers might be responsible for the immune cell dysregulation that shapes the protumor microenvironment. We performed a transcriptome analysis of coding and non-coding RNAs (ncRNAs) during leukemia progression in the Rag2-/-γc-/- MEC1-based xenotransplantation model. The DLEU2/miR-16 locus was found downmodulated in monocytes/macrophages of leukemic mice. To validate the role of this cluster in the tumor immune microenvironment, we generated a mouse model that simultaneously mimics the overexpression of hTCL1 and the germline deletion of the …