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About: Bibliography Of Sources Consulted (As Of February 2025), University Of Mississippi Libraries. Archives And Special Collections Feb 2025

About: Bibliography Of Sources Consulted (As Of February 2025), University Of Mississippi Libraries. Archives And Special Collections

Books at Rowan Oak, Home of William Faulkner

No abstract provided.


Multimorbidity And Peak Oxygen Uptake In Patients Undergoing Cardiac Rehabilitation, Pauline F. Gomes, Audry Chacin-Suarez, Sophie A. Miller, Karen M. Fischer, Thomas P. Olson Feb 2025

Multimorbidity And Peak Oxygen Uptake In Patients Undergoing Cardiac Rehabilitation, Pauline F. Gomes, Audry Chacin-Suarez, Sophie A. Miller, Karen M. Fischer, Thomas P. Olson

Einstein Health Papers

No abstract provided.


Development And Validation Of Risk Stratification For Heart Failure After Acute Coronary Syndrome Based On Dynamic S100a8/A9 Levels, Jie Ma, Ke Ma, Jing Chen, Xinying Yang, Fei Gao, Hai Gao, Hui Zhang, Xin-Liang Ma, Jie Du, Ping Li, Yulin Li Feb 2025

Development And Validation Of Risk Stratification For Heart Failure After Acute Coronary Syndrome Based On Dynamic S100a8/A9 Levels, Jie Ma, Ke Ma, Jing Chen, Xinying Yang, Fei Gao, Hai Gao, Hui Zhang, Xin-Liang Ma, Jie Du, Ping Li, Yulin Li

Department of Emergency Medicine Faculty Papers

BACKGROUND: The early assessment of heart failure (HF) risk in patients with acute coronary syndrome (ACS) can help reduce mortality. S100A8/A9 is not only rapidly released after myocardial ischemia, but is also involved in reperfusion injury, which is an important predictor of HF after ACS. We attempted to construct a reliable HF risk stratification tool for evaluating patients with ACS after reperfusion therapy based on S100A8/A9 dynamic changes.

METHODS AND RESULTS: This prospective study included 3 independent cohorts of patients with ACS who received reperfusion therapy. The discovery cohort was divided into 2 subgroups: the longitudinal subgroup (n=264) with serum …


Spending Changes After Moving To Areas With Greater Aco Participation Among Nonattributed Medicare Beneficiaries, Yucheng Hou, Marisa Elena Domino, Valerie A Lewis, Qing Gong, Kevin Callison, Justin G Trogdon Feb 2025

Spending Changes After Moving To Areas With Greater Aco Participation Among Nonattributed Medicare Beneficiaries, Yucheng Hou, Marisa Elena Domino, Valerie A Lewis, Qing Gong, Kevin Callison, Justin G Trogdon

Faculty, Staff and Student Publications

IMPORTANCE: Accountable care organizations (ACOs) under the Medicare Shared Savings Program have long been envisioned as a pathway to improved care efficiency and quality of care for all Medicare beneficiaries. However, little is known about whether the changes in health care spending associated with ACOs have extended beyond ACO-attributed Medicare beneficiaries to all Medicare beneficiaries.

OBJECTIVE: To estimate spending changes by non-ACO-attributed Medicare beneficiaries after moving to geographic areas with greater ACO participation.

DESIGN, SETTING, AND PARTICIPANTS: This repeated cross-sectional study analyzed claims from a 20% representative sample of all Medicare beneficiaries, aged 65 to 99 years, from 2009 to …


Sleep Trajectories And All-Cause Mortality Among Low-Income Adults, Kelsie M Full, Hui Shi, Loren Lipworth, Lawrence T Dauer, Michael T Mumma, Qian Xiao Feb 2025

Sleep Trajectories And All-Cause Mortality Among Low-Income Adults, Kelsie M Full, Hui Shi, Loren Lipworth, Lawrence T Dauer, Michael T Mumma, Qian Xiao

Faculty, Staff and Student Publications

IMPORTANCE: Short and long sleep durations are adversely associated with cardiovascular disease (CVD), type 2 diabetes, and mortality. It remains unclear how sleep duration trajectories over time are associated with mortality and whether these associations vary by well-documented sex, race, and socioeconomic sleep disparities.

OBJECTIVE: To investigate the association of 5-year sleep duration trajectories with all-cause and cause-specific mortality among US adults, predominantly those in low-income groups.

DESIGN, SETTING, AND PARTICIPANTS: The Southern Community Cohort Study included participants aged 40 to 79 years recruited and enrolled (from March 2002 to September 2009) from community health centers by using random sampling …


What The Hell Is The Major Questions Doctrine?, Jack M. Beermann Feb 2025

What The Hell Is The Major Questions Doctrine?, Jack M. Beermann

Faculty Scholarship

Anita S. Krishnakumar, What the New Major Questions Doctrine Is Not, 92 Geo. Wash. L. Rev. 1117 (2024).

When the sun sets in New York City, it rises in Tokyo. Okay, maybe not exactly, but you get the idea: setting somewhere, rising somewhere else. Now substitute Chevron for N.Y.C. and the Major Questions Doctrine for Tokyo. For the past forty years, administrative law scholars have been arguing over Chevron, and now that the sun has set on that doctrine, it’s time to turn our attention to the new rising sun, the Major Questions Doctrine (“MQD”). The sudden emergence …


Characterizing The Genetic Basis For Inherited Retinal Disease: Lessons Learned From The Foundation Fighting Blindness Clinical Consortium's Gene Poll, Kari Branham, Lassana Samarakoon, Isabelle Audo, Allison R Ayala, Janet K Cheetham, Stephen P Daiger, Patty Dhooge, Jacque L Duncan, Todd A Durham, Abigail T Fahim, Rachel M Huckfeldt, Robert B Hufnagel, Susanne Kohl, Ramiro S Maldonado, Michele Melia, Michel Michaelides, Mark E Pennesi, José-Alain Sahel, Juliana M Ferraz Sallum, Mandeep S Singh, Dror Sharon, Kimberly Stepien, Kaylie Jones, Christina Y Weng Feb 2025

Characterizing The Genetic Basis For Inherited Retinal Disease: Lessons Learned From The Foundation Fighting Blindness Clinical Consortium's Gene Poll, Kari Branham, Lassana Samarakoon, Isabelle Audo, Allison R Ayala, Janet K Cheetham, Stephen P Daiger, Patty Dhooge, Jacque L Duncan, Todd A Durham, Abigail T Fahim, Rachel M Huckfeldt, Robert B Hufnagel, Susanne Kohl, Ramiro S Maldonado, Michele Melia, Michel Michaelides, Mark E Pennesi, José-Alain Sahel, Juliana M Ferraz Sallum, Mandeep S Singh, Dror Sharon, Kimberly Stepien, Kaylie Jones, Christina Y Weng

Faculty, Staff and Students Publications

PURPOSE: The Foundation Fighting Blindness (FFB) Consortium is a collaboration of 41 international clinical centers that manage patients affected with inherited retinal diseases (IRDs). The annual Consortium gene poll was initiated in 2020 to capture the genetic cause of disease in patients with IRD and associated clinical practices of Consortium sites. Data from the 2022 gene poll are reported here.

METHODS: In 2022, academic, private practice, and government ophthalmology clinics that are members of the Consortium centers were polled to identify per-case IRD genetic causality from a list of 387 syndromic and nonsyndromic IRD genes. The survey also assessed how …


Are Positive And Negative Leader Humor Two Different Coins? A Meta-Analysis, Xiaohong Xu, Richard Hayes, Lixin Jiang, William P. Jimenez Feb 2025

Are Positive And Negative Leader Humor Two Different Coins? A Meta-Analysis, Xiaohong Xu, Richard Hayes, Lixin Jiang, William P. Jimenez

Psychology Faculty Publications

Scholars disagree on the distinction between positive and negative leader humor, which may hinder the integration and advancement of the leader humor literature. Thus, we meta-analyzed the correlation between positive and negative leader humor, as well as their shared nomological networks (k = 161; follower N = 45,759; leader N = 7,820). Our meta-analysis indicates that (1) there is a very small but significant correlation between positive and negative leader humor (ρ = -.07); (2) positive and negative leader humor have differential relationships with most antecedents (e.g., positive affectivity) and outcomes (e.g., innovation and citizenship behavior); (3) positive affect …


From Bench To Bedside: Murine Models Of Inherited And Sporadic Brain Arteriovenous Malformations, Ashely R Ricciardelli, Gael Genet, Nafiisha Genet, Samuel T Mcclugage, Peter T Kan, Karen K Hirschi, Jason E Fish, Joshua D Wythe Feb 2025

From Bench To Bedside: Murine Models Of Inherited And Sporadic Brain Arteriovenous Malformations, Ashely R Ricciardelli, Gael Genet, Nafiisha Genet, Samuel T Mcclugage, Peter T Kan, Karen K Hirschi, Jason E Fish, Joshua D Wythe

Faculty, Staff and Students Publications

Brain arteriovenous malformations are abnormal vascular structures in which an artery shunts high pressure blood directly to a vein without an intervening capillary bed. These lesions become highly remodeled over time and are prone to rupture. Historically, brain arteriovenous malformations have been challenging to treat, using primarily surgical approaches. Over the past few decades, the genetic causes of these malformations have been uncovered. These can be divided into (1) familial forms, such as loss of function mutations in TGF-β (BMP9/10) components in hereditary hemorrhagic telangiectasia, or (2) sporadic forms, resulting from somatic gain of function mutations in genes involved in …


Short Duration Of Antenatal Corticosteroid Exposure And Outcomes In Extremely Preterm Infants, Sanjay Chawla, Myra H Wyckoff, Satyan Lakshminrusimha, Matthew A Rysavy, Ravi Mangal Patel, Dhuly Chowdhury, Abhik Das, Rachel G Greenberg, Girija Natarajan, Seetha Shankaran, Edward F Bell, Namasivayam Ambalavanan, Noelle E Younge, Abbot R Laptook, Leeann R Pavlek, Carl H Backes, Krisa P Van Meurs, Erika F Werner, Waldemar A Carlo, National Institute Of Child Health And Human Development (Nichd) Neonatal Research Network (Nrn) Feb 2025

Short Duration Of Antenatal Corticosteroid Exposure And Outcomes In Extremely Preterm Infants, Sanjay Chawla, Myra H Wyckoff, Satyan Lakshminrusimha, Matthew A Rysavy, Ravi Mangal Patel, Dhuly Chowdhury, Abhik Das, Rachel G Greenberg, Girija Natarajan, Seetha Shankaran, Edward F Bell, Namasivayam Ambalavanan, Noelle E Younge, Abbot R Laptook, Leeann R Pavlek, Carl H Backes, Krisa P Van Meurs, Erika F Werner, Waldemar A Carlo, National Institute Of Child Health And Human Development (Nichd) Neonatal Research Network (Nrn)

Faculty, Staff and Student Publications

Importance: When preterm delivery is imminent, it remains unclear whether the timing from administration of antenatal betamethasone to birth may reduce mortality and morbidity among extremely preterm infants.

Objective: To evaluate the association of duration from exposure to first dose of antenatal betamethasone with outcomes among extremely preterm infants.

Design, setting, and participants: This cohort study enrolled infants born at 22 0/7 to 27 6/7 weeks' gestation from January 2016 to February 2021 at National Institute of Child Health and Human Development Neonatal Research Network centers. Infants exposed to multiple doses of antenatal betamethasone, infants who did not receive intensive …


The 3rd Annual Alexander C. Cushing International Law Conference: "Rule Of Law In The Indo-Pacific Region And Beyond", Stockton Center For International Law Feb 2025

The 3rd Annual Alexander C. Cushing International Law Conference: "Rule Of Law In The Indo-Pacific Region And Beyond", Stockton Center For International Law

Cushing International Law Conference

Hosted annually by the Stockton Center for International Law, the Alexander C. Cushing International Law Conference brings together scholars and practitioners from across the world to develop and shape international maritime law and governance. This year, we will focus on the rule of law and great power competition in the Indo-Pacific region and the Arctic Ocean, as well as exploring climate change and illegal fishing.


Structural Insights Into Light-Gating Of Potassium-Selective Channelrhodopsin, Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Probal Nag, Tal Dogon, Oleg A Sineshchekov, Yumei Wang, Leonid S Brown, Songhwan Hwang, Han Sun, Ana-Nicoleta Bondar, Igor Schapiro, Elena G Govorunova, John L Spudich, Oliver P Ernst Feb 2025

Structural Insights Into Light-Gating Of Potassium-Selective Channelrhodopsin, Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Probal Nag, Tal Dogon, Oleg A Sineshchekov, Yumei Wang, Leonid S Brown, Songhwan Hwang, Han Sun, Ana-Nicoleta Bondar, Igor Schapiro, Elena G Govorunova, John L Spudich, Oliver P Ernst

Faculty, Staff and Student Publications

Structural information on channelrhodopsins' mechanism of light-gated ion conductance is scarce, limiting its engineering as optogenetic tools. Here, we use single-particle cryo-electron microscopy of peptidisc-incorporated protein samples to determine the structures of the slow-cycling mutant C110A of kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) in the dark and upon laser flash excitation. Upon photoisomerization of the retinal chromophore, the retinylidene Schiff base NH-bond reorients from the extracellular to the cytoplasmic side. This switch triggers a series of side chain reorientations and merges intramolecular cavities into a transmembrane K+ conduction pathway. Molecular dynamics simulations confirm K+ flux through the illuminated state …


Consistency Of Hfref Treatment Effect In Underrepresented Groups In Randomized Clinical Trials, Guillaume Baudry, Luca Monzo, Mark C. Petrie, Nicolas Girerd, Iliana L Piña, Alexandre Mebazaa, Javed Butler, Leila Abid, Faiez Zannad, Harriette G.C. Van Spall Feb 2025

Consistency Of Hfref Treatment Effect In Underrepresented Groups In Randomized Clinical Trials, Guillaume Baudry, Luca Monzo, Mark C. Petrie, Nicolas Girerd, Iliana L Piña, Alexandre Mebazaa, Javed Butler, Leila Abid, Faiez Zannad, Harriette G.C. Van Spall

Division of Cardiology Faculty Papers

Despite the established efficacy of heart failure (HF) guideline-directed medical therapies, implementation varies across demographic groups, including Black, Indigenous, and people of color, older adults, females, and those who are socioeconomically deprived. This review synthesizes the representativeness of trial participants and describes subgroup analyses from pivotal trials in HF with reduced ejection fraction (HFrEF). It reviews the largely consistent treatment effect of medical therapies across the demographic groups represented in trials. It makes arguments for broad implementation of therapies based on these data, while calling for more representative trials to improve research and health equity in HF.


Active Learning-Based Automated Construction Of Hamiltonian For Structural Phase Transitions: A Case Study On Batio3, Mian Dai, Yixuan Zhang, Nuno Fortunato, Peng Chen, Hongbin Zhang Feb 2025

Active Learning-Based Automated Construction Of Hamiltonian For Structural Phase Transitions: A Case Study On Batio3, Mian Dai, Yixuan Zhang, Nuno Fortunato, Peng Chen, Hongbin Zhang

Physics Faculty Publications and Presentations

The effective Hamiltonians have been widely applied to simulate the phase transitions inpolarizable materials, with coefficients obtained by fitting to accurate first-principlescalculations. However, it is tedious to generate distorted structures with symmetry constraints,in particular when high-ordered terms are considered. In this work, we implement and apply aBayesian optimization-based approach to sample potential energy surfaces, automating theeffective Hamiltonian construction by selecting distorted structures via active learning. Taking BaTiO3(BTO) as an example, we demonstrate that the effective Hamiltonian can be obtainedusing fewer than 30 distorted structures. Follow-up Monte Carlo simulations can reproduce thestructural phase transition temperatures of BTO, comparable to experimental values …


Distinct Roles Of Mtorc2 In Excitatory And Inhibitory Neurons In Inflammatory And Neuropathic Pain, Wei He, Xin Ge, Ru-Rong Ji Feb 2025

Distinct Roles Of Mtorc2 In Excitatory And Inhibitory Neurons In Inflammatory And Neuropathic Pain, Wei He, Xin Ge, Ru-Rong Ji

Faculty, Staff and Student Publications

No abstract provided.


Routes To Social Prescribing Outside National Health Service (Nhs) Structures: A Systematic Map, Emma Hazeldine, Sophie Westwood, Mohammad Hassannezhad, Stephanie Tierney, Lucy Gavens, Kerryn Husk Feb 2025

Routes To Social Prescribing Outside National Health Service (Nhs) Structures: A Systematic Map, Emma Hazeldine, Sophie Westwood, Mohammad Hassannezhad, Stephanie Tierney, Lucy Gavens, Kerryn Husk

Peninsula Medical School

Objectives Social prescribing, linking to community-based interventions to support individuals’ health and well-being, has become established across social medicine in the UK. Currently, most of the evidence and knowledge about how social prescribing pathways’ function focuses on primary care, and we know less about how social prescribing operates outside of these structures. This review explored the evidence concerning non-health service delivered social prescribing with a view to developing guidance that would support social prescribing pathways that function outside of the health service framework.Design This paper reports a systematic mapping review of evidence concerning how community-based social prescribing pathways were delivered, …


The Efficacy Of India's Electric Vehicle Market: Can Fame Deliver Results?, Douglas N. Hales, Gawon Yun, Devendra Kale Feb 2025

The Efficacy Of India's Electric Vehicle Market: Can Fame Deliver Results?, Douglas N. Hales, Gawon Yun, Devendra Kale

Markets, Globalization & Development Review

This commentary discusses the merits and demerits of India's FAME I II and III policy frameworks to promote the use of electric vehicles (EVs). FAME III is under consideration, and some suggestions are offered to improve its effectiveness.


Emerging Trends In Supply Chain Resilience: A Systematic Literature Review, Cemre Şerbetçioğlu, Bengü Sevil Oflaç Feb 2025

Emerging Trends In Supply Chain Resilience: A Systematic Literature Review, Cemre Şerbetçioğlu, Bengü Sevil Oflaç

Markets, Globalization & Development Review

Following the COVID-19 pandemic, the increased geopolitical tensions and trade wars and increased frequency of extreme weather conditions due to climate change revealed the importance of building resilience to mitigate the impact of such unforeseen challenges. Understanding supply chain resilience and building capabilities is essential for quickly responding to and recovering from disruptions. With the PRISMA approach, 335 articles were analyzed to illuminate the multifaceted nature of supply chain capabilities by synthesizing existing research on resilience, identifying key trends, and highlighting areas for future investigation.

By identifying key trends in supply chain resilience, this study makes significant contributions to the …


The Kindle Ecosystem Of Overconsumption: The Digital Flâneuse Roaming Booktok E-Spaces, Valeria Baltodano Feb 2025

The Kindle Ecosystem Of Overconsumption: The Digital Flâneuse Roaming Booktok E-Spaces, Valeria Baltodano

Markets, Globalization & Development Review

The development of a community and culture around reading on the social media platform has afforded women new avenues for empowerment through their earning and spending power. A tool wielded often in this mobile space, Amazon’s Kindle device has reached a new height of popularity thanks to the women in the bookish community of TikTok. This paper employs Anne Friedberg’s concept of the flâneuse in relation to the limitation of women’s empowerment through the commodification and aestheticization of reading on TikTok. It demonstrates how the Kindle has become the locus for a culture of overconsumption through which these women exercise …


Eng 1091g-290 College Composition I Critical Reading & Source-Based Writing, Honors, C.C. Wharram Feb 2025

Eng 1091g-290 College Composition I Critical Reading & Source-Based Writing, Honors, C.C. Wharram

Fall 2024

No abstract provided.


Martin "Marty" Shichtman, Oral History Interview, 2025, Kat Hacanyan Feb 2025

Martin "Marty" Shichtman, Oral History Interview, 2025, Kat Hacanyan

Oral Histories

Martin "Marty" Shichtman is professor emeritus and the Founding Director of the Center for Jewish Studies at EMU. A professor of English and Literature for nearly four decades, Shichtman taught both graduate and undergraduate level courses in subjects like Arthurian literature and Jewish-American literature. During his tenure at EMU he introduced the first Jewish Studies class, which soon led to the creation of a Jewish Studies minor, and eventually the Center for Jewish Studies. Shichtman served as the center's director from its opening in 2012 to his retirement in 2022 and continues to be involved as a member of the …


Fieldnote 21: Writing As Resistance, Venus Evans-Winters Dr. Feb 2025

Fieldnote 21: Writing As Resistance, Venus Evans-Winters Dr.

Fieldnotes of a Black Woman Scholar: Research, Culture, and Wellness

In this episode of Writing What I Like: Fieldnotes of a Black Woman Scholar, we explore how toxic work environments and systemic oppression impact mental health and creativity. Discover how writing can be a transformative tool to process these challenges, resist burnout, and reclaim your voice. Join me, Dr. Venus Evans-Winters, as I share practical exercises and strategies to empower you to turn your experiences into powerful narratives of resilience and resistance.


Cardiovascular Disease In Adults With Osteogenesis Imperfecta: Clinical Characteristics, Care Recommendations, And Research Priorities Identified Using A Modified Delphi Technique, Lars Folkestad, Siddharth K Prakash, Sandesh C S Nagamani, Niels Holmark Andersen, Erin Carter, Jannie Dahl Hald, Riley J Johnson, Bente Langdahl, Eleanor M Perfetto, Cathleen Raggio, Stuart H Ralston, Robert A Sandhaus, Oliver Semler, Laura Tosi, Eric Orwoll Feb 2025

Cardiovascular Disease In Adults With Osteogenesis Imperfecta: Clinical Characteristics, Care Recommendations, And Research Priorities Identified Using A Modified Delphi Technique, Lars Folkestad, Siddharth K Prakash, Sandesh C S Nagamani, Niels Holmark Andersen, Erin Carter, Jannie Dahl Hald, Riley J Johnson, Bente Langdahl, Eleanor M Perfetto, Cathleen Raggio, Stuart H Ralston, Robert A Sandhaus, Oliver Semler, Laura Tosi, Eric Orwoll

Faculty, Staff and Student Publications

Osteogenesis imperfecta (OI) is a multisystem disorder most often caused by pathogenic variants in genes that encode type I collagen. Type I collagen is abundant not only in bone but also in multiple tissues including skin, tendons, cornea, blood vessels, and heart. Thus, OI can be expected to affect cardiovascular system, and there are numerous reports of cardiovascular disease (CVD) in people with OI. However, there is no consensus on how CVD in OI should be assessed or managed. To fill this gap, a multidisciplinary group was convened to develop clinical guidance. The work included a systematic review of the …


The Impact Of Short-Term Study Abroad (Stsa) Program On Intercultural Competence Of Students At A Frontier/Rural Campus, Neely Mahapatra, Carolyn Haney, Derek Waite Feb 2025

The Impact Of Short-Term Study Abroad (Stsa) Program On Intercultural Competence Of Students At A Frontier/Rural Campus, Neely Mahapatra, Carolyn Haney, Derek Waite

Journal of Comparative & International Higher Education

No abstract provided.


Dairy Consumption And The Colonic Mucosa-Associated Gut Microbiota In Humans-A Preliminary Investigation, Ellie Chen, Nadim J Ajami, Donna L White, Yanhong Liu, Shawn Gurwara, Kristi Hoffman, David Y Graham, Hashem B El-Serag, Joseph F Petrosino, Li Jiao Feb 2025

Dairy Consumption And The Colonic Mucosa-Associated Gut Microbiota In Humans-A Preliminary Investigation, Ellie Chen, Nadim J Ajami, Donna L White, Yanhong Liu, Shawn Gurwara, Kristi Hoffman, David Y Graham, Hashem B El-Serag, Joseph F Petrosino, Li Jiao

Faculty, Staff and Students Publications

Background: Dairy consumption has been associated with various health outcomes that may be mediated by changes in gut microbiota.

Methods: This cross-sectional study investigated the association between the colonic mucosa-associated gut microbiota and the self-reported intake of total dairy, milk, cheese, and yogurt. A total of 97 colonic mucosal biopsies collected from 34 polyp-free individuals were analyzed. Dairy consumption in the past year was assessed using a food frequency questionnaire. The 16S rRNA gene V4 region was amplified and sequenced. Operational taxonomic unit (OTU) classification was performed using the UPARSE and SILVA databases. OTU diversity and relative abundance were compared …


Designing Contract Modification, Albert H. Choi, George Triantis Feb 2025

Designing Contract Modification, Albert H. Choi, George Triantis

Law & Economics Working Papers

For long-term commercial contracts, modification tends to be the norm rather than the exception. While modification often takes place in response to an arrival of new information, contracting parties frequently modify the terms in response to a shift in bargaining power. In this paper, we explain how the flexibility to renegotiate in response to a shift in bargaining power can facilitate long-term contracting and thereby beneficial reliance investments and risk allocation. The prospect of modification can induce contracting parties who expect their bargaining power to improve, such as from the emergence of outside opportunities, to enter into contracts earlier and …


Most Infants With Prenatal Osteogenesis Imperfecta Diagnosis And Poor Prognosis Survive: Experience Of A Quaternary Care Osteogenesis Imperfecta Center, Ricki S. Carroll, Sarah Little, Tina Mcgreal, Shannon Bonner, Daria Willis, Jeanne M. Franzone, Jeffery Campbell, Margaret Chou, Megan B. Raymond, Andrea Schelhaas, Joanna Costa, Mahim Jain Feb 2025

Most Infants With Prenatal Osteogenesis Imperfecta Diagnosis And Poor Prognosis Survive: Experience Of A Quaternary Care Osteogenesis Imperfecta Center, Ricki S. Carroll, Sarah Little, Tina Mcgreal, Shannon Bonner, Daria Willis, Jeanne M. Franzone, Jeffery Campbell, Margaret Chou, Megan B. Raymond, Andrea Schelhaas, Joanna Costa, Mahim Jain

Department of Obstetrics and Gynecology Faculty Papers

Osteogenesis imperfecta is a genetic condition with improperly or inadequately produced Type I collagen. Manifestations include bowing deformities, fractures, hydrocephalus, respiratory insufficiency, and feeding difficulty. Moderate or severe OI is often diagnosed prenatally based on ultrasound findings and genetic testing may be labeled as lethal. Here, we present 18 infants with moderate to severely presenting OI who received neonatal care at a single center over a 5 yr period, 10 of which were delivered at our institution. All 18 infants survived to neonatal discharge, with 7 infants requiring respiratory support and 9 infants requiring feeding support at discharge. Through Fisher …


Pharmacogenetic And Microrna Mechanisms Of Beta Blocker Use On Bone, Christine W Lary, Elizabeth J Atkinson, Jennifer Spillane, Zannatun Nayema, Tyler A Roy, Rebecca Peters, Griffin T Scott, Hongyu Chen, Archana Nagarajan, Aaron Brown, Katherine J Motyl, David G Monroe, Sundeep Khosla Feb 2025

Pharmacogenetic And Microrna Mechanisms Of Beta Blocker Use On Bone, Christine W Lary, Elizabeth J Atkinson, Jennifer Spillane, Zannatun Nayema, Tyler A Roy, Rebecca Peters, Griffin T Scott, Hongyu Chen, Archana Nagarajan, Aaron Brown, Katherine J Motyl, David G Monroe, Sundeep Khosla

Faculty, Staff and Students Publications

Motivated by studies showing an association between beta blocker (BB) use and positive bone outcomes, a pilot randomized control trial was performed at the Mayo Clinic which randomized postmenopausal women to placebo, propranolol (40 or 80 mg twice daily), atenolol (50 mg/d), or nebivolol (5 mg/d) to determine changes in bone turnover markers (BTMs) and in BMD over 20 wk. Pharmacogenetic effects and microRNA-mediated mechanisms involving beta adrenergic receptor and related genes have previously been found. We sought to validate these effects and discover new candidates in an ancillary study to the pilot clinical trial. We genotyped all participants and …


Investigating The In Vivo Effects Of Anti-Prion Protein Nanobodies On Prion Disease With Aav Vector, Jingjing Zhang, Mengfei Wang, Dan Wang, Xiangyi Zhang, Yue Ma, Els Pardon, Jan Steyaert, Romany Abskharon, Fei Wang, Jiyan Ma Feb 2025

Investigating The In Vivo Effects Of Anti-Prion Protein Nanobodies On Prion Disease With Aav Vector, Jingjing Zhang, Mengfei Wang, Dan Wang, Xiangyi Zhang, Yue Ma, Els Pardon, Jan Steyaert, Romany Abskharon, Fei Wang, Jiyan Ma

Faculty, Staff and Student Publications

Prion diseases are fatal neurodegenerative disorders affecting humans and animals, and the central pathogenic event is the conversion of normal prion protein (PrPC) into the pathogenic PrPSc isoform. Previous studies have identified nanobodies that specifically recognize PrPC and inhibit the PrPC to PrPSc conversion in vitro. In this study, we investigated the potential for in vivo expression of anti-PrPC nanobodies and evaluated their impact on prion disease. The coding sequences of three nanobodies were packaged into recombinant adeno-associated virus (rAAV) and were administered via intracerebroventricular (ICV) injection in newborn mice. We found that the expression of these nanobodies remained robust …


Frameworks For Measuring Regenerative Tourism: Supply And Demand Indicators With A Dynamic And Holistic Approach, Asif Hussain Feb 2025

Frameworks For Measuring Regenerative Tourism: Supply And Demand Indicators With A Dynamic And Holistic Approach, Asif Hussain

Journal of Sustainability and Resilience

This paper examines regenerative tourism as a holistic approach that goes beyond sustainability by actively restoring and enhancing social-ecological systems. Recognizing tourism’s interconnectedness with economic, social, cultural, and environmental systems, it presents regenerative tourism as a dynamic model integrating supply and demand perspectives to promote innovation, resilience, and renewal. On the supply side, regenerative tourism emphasizes ecological restoration, sustainable practices, economic stability with minimal environmental harm, and authentic experiences. On the demand side, it aligns with the rising preference for ethical, participatory, and immersive tourism, involving tourists as active contributors to destination well-being. The paper highlights the importance of multidimensional …