Digital Commons Network^™

Tfap2e Is Implicated In Central Nervous System, Orofacial And Maxillofacial Anomalies, Jeshurun C Kalanithy, Enrico Mingardo, Jil D Stegmann, Ramgopal Dhakar, Tikam Chand Dakal, Jill A Rosenfeld, Wen-Hann Tan, Stephanie A Coury, Audrey C Woerner, Jessica Sebastian, Paul A Levy, Leah R Fleming, Lea Waffenschmidt, Tobias T Lindenberg, Öznur Yilmaz, Khadija Channab, Bimaljeet K Babra, Andrea Christ, Britta Eiberger, Selina Hölzel, Clara Vidic, Felix Häberlein, Nina Ishorst, Juan E Rodriguez-Gatica, Behnaz Pezeshkpoor, Patrick A Kupczyk, Olivier M Vanakker, Sara Loddo, Antonio Novelli, Maria L Dentici, Albert Becker, Holger Thiele, Jennifer E Posey, James R Lupski, Alina C Hilger, Heiko M Reutter, Waltraut M Merz, Gabriel C Dworschak, Benjamin Odermatt

Faculty, Staff and Students Publications

Background: Previous studies in mouse, Xenopus and zebrafish embryos show strong tfap2e expression in progenitor cells of neuronal and neural crest tissues suggesting its involvement in neural crest specification. However, the role of human transcription factor activator protein 2 (TFAP2E) in human embryonic central nervous system (CNS), orofacial and maxillofacial development is unknown.

Methods: Through a collaborative work, exome survey was performed in families with congenital CNS, orofacial and maxillofacial anomalies. Exome variant prioritisation prompted TFAP2E gene for functional analysis in zebrafish embryos. Embryonic morphology and development were assessed after antisense morpholino (MO) knockdown (KD), CRISPR/Cas9 knockout and overexpression …

Early-Onset Atherosclerotic Cardiovascular Disease, Idine Mousavi, John Suffredini, Salim S Virani, Christie M Ballantyne, Erin D Michos, Arunima Misra, Anum Saeed, Xiaoming Jia

Faculty, Staff and Students Publications

Recent trends indicate a concerning increase in early-onset atherosclerotic cardiovascular disease (ASCVD) among younger individuals (men aged < 55 years women aged < 65 years). These findings highlight the pathobiology of ASCVD as a disease process that begins early in life and underscores the need for more tailored screening methods and preventive strategies. Increasing attention has been placed on the growing burden of traditional cardiometabolic risk factors in young individuals while also recognizing unique factors that mediate risk of pre-mature atherosclerosis in this demographic such as substance use, socioeconomic disparities, adverse pregnancy outcomes, and chronic inflammatory states that contribute to the increasing incidence of early ASCVD. Additionally, mounting evidence has pointed out significant disparities in the diagnosis and management of early ASCVD and cardiovascular outcomes based on sex and race. Moving towards a more personalized approach, emerging data and technological developments using diverse tools such as polygenic risk scores and coronary artery calcium scans have shown potential in earlier detection of ASCVD risk. Thus, we review current evidence on causal risk factors that drive the increase in early ASCVD and highlight emerging tools to improve ASCVD risk assessment in young individuals.

The Law Of Ai For Good, Orly Lobel

Florida Law Review

Legal policy and scholarship are increasingly focused on regulating technology to safeguard against risks and harms, neglecting the ways in which the law should direct the use of new technology, particularly artificial intelligence (AI), for positive purposes. This Article pivots the debates about automation, finding that the focus on AI wrongs is descriptively inaccurate because it undermines a balanced analysis of the benefits, potentials, and risks involved in digital technology. Further, the focus on AI wrongs is normatively and prescriptively flawed, as it narrows and distorts the law reforms currently dominating tech policy debates. The Law-of-AI-Wrongs focuses on reactive and …

Disrupting Creativity: Copyright Law In The Age Of Generative Artifical Intelligence, Ryan Abbott, Elizabeth Rothman

Florida Law Review

Over the last few years, due largely to breakthroughs in deep learning technologies, artificial intelligence (AI) has begun to step into the shoes of human content generators and make valuable creative works at scale. Before the end of the decade, a significant amount of art, literature, music, software, and web content will likely be created by AI rather than traditional human authors. Yet the law lags behind this technological evolution by prohibiting copyright protection for AI-generated works. The predominant narrative holds that even if AI can automate creativity, this activity is not the right sort of thing to protect, and …

"Blurred Lines" On The "Stairway To Heaven": How The Sound Of Music Can Clarify Substantial Similarity In Music Copyright Cases, Lindsey O'Brien

Florida Law Review

Copyright law sits at the heart of the multibillion-dollar music industry. Recently, the Ninth Circuit has served as a common venue for resolving disputes between musical artists in alleged copyright infringement cases. However, the logic surrounding legal decisions is often contrary to the realities of the music industry, and results have been inconsistent even within the same circuit. The unpredictability of legal outcomes leaves the “best” standard for evaluating music copyright infringement unclear. This Note argues that, when considering copyright law’s historical underpinnings, a literal application of existing doctrine proves less-than-ideal in the context of music. The law’s emphasis on …

State Power And Anticompetitive Conduct, Gregory Day

Florida Law Review

States can and do suppress competition when it harms marginalized communities. For example, states have monopolized prison markets, forcing society’s least powerful to pay high prices for medicine, snacks, and other goods. It is also common for states to organize licensing agencies who can protect incumbent interests by refusing to grant licenses to immigrant entrepreneurs such as African hair braiders, street vendors, and more. From current and historical perspectives, anticompetitive practices have quietly entailed one of the most effective methods of oppressing marginalized people. That said, states are exempted from antitrust review due to federalism, which concerns constitutional power sharing …

"It's A Sham!": How Sham Political Candidates Are Threatening Democracy, David B. Allen

Florida Law Review

By means of the U.S. election system, democracy in America is under attack—from within. If action is not taken, the public’s trust in elections will plummet to the lowest point in the history of this country. This Note brings to light a little-known political trick: sham political candidates. Political operatives place sham candidates on the ballot to siphon votes from opposing candidates. And the most shocking fact of it all is that it is completely legal. This Note identifies how sham candidates have impacted the modern election, while also examining the history of U.S. elections and election laws. This Note …

Adversary Democratic Due Process, Martin H. Redish, Victor Hiltner

Florida Law Review

Legal minds have long quarreled over the true meaning of the Due Process Clauses of the Fifth and Fourteenth Amendments, but little consensus has emerged as to their scope and application. Despite the doctrinal significance and ubiquity of due process, scholars have devoted troublingly little attention to the underlying premises or “DNA” of this fundamental constitutional right. Consequently, litigants’ claims to adjudicatory procedures have been consistently undervalued on the myopic utilitarian scale of costs and benefits that has imposed a chokehold on current doctrine, and no viable alternative approach has emerged to take its place. This Article seeks to fill …

Book Review, Augusto S. Auler

International Journal of Speleology

No abstract provided.

Eng 1002g-002 College Composition Ii Argument And Critical Inquiry, Lydia Craig

Fall 2024

No abstract provided.

Influence Of High Eimeria Tenella Immunization Dosages On Total Oocyst Output And Specific Antibodies Recognition Response In Hybrid Pullets (Gallus Gallus)-A Pilot Study, Marco A. Juarez-Estrada, Guillermo Tellez-Isaias, Victor M. Petrone-Garcia, Amanda Gayosso-Vazquez, Xochitl Hernandez-Velasco, Rogelio A. Alonso-Morales

Political Science Faculty Publications and Presentations

Background: Two high primary-immunization doses of a wild-type E. tenella strain were assessed in healthy pullets (5K versus 10K sporulated oocysts/bird) to understand the effects of coccidia infection. Methods: Acquired immunity was evaluated following primary immunization and two booster doses with the homologous strain. Total oocyst shedding, clinical signs, and viability of every bird/group after each immunization/booster were recorded. Indirect ELISA measured the time course of humoral responses from each immunization group against sporozoite and second-generation merozoite of E. tenella. Antigen pattern recognition on these two asexual zoite stages of E. tenella was analyzed using Western blotting with antibodies from …

An Investigation Of Travel Distance And Timeliness Of Breast Cancer Treatment Among A Diverse Cohort In The United States, Swann Arp Adams, Oluwole Adeyemi Babatunde, Whitney Zahnd, Peiyin Hung, Karen E. Wickersham, Nathaniel Bell Ph.D., Jan M. Eberth Ph.D.

Publications

Travel to and from distant cancer treatment facilities can place a significant burden on cancer patients, particularly rural and minority survivors. Thus, the purpose of our investigation was to examine the association between patient travel distance and delays in types of treatment for breast cancer (surgery, radiation, chemotherapy, and hormonal therapy) and treatment delays. Using a novel linkage between the state cancer registry and administrative data from Medicaid and a private insurance plan, 2155 BC patients were successfully linked to create the cohort. ArcGIS was used to geocode all case residences and treatment facility addresses and calculate network distance between …

Carbon Monoxide-Oxidising Pseudomonadota On Volcanic Deposits, Robin A. Dawson Phd, Rn, Cpnp-Pc, Nicola Fantom, Tamara Martin-Pozas, Patricia Aguila, Gary M. King, Marcela Hernández

Publications

Carbon monoxide (CO) oxidising microorganisms are present in volcanic deposits throughout succession, with levels of vegetation and soil influencing the communities present. Carboxydovores are a subset of CO oxidisers that use CO as an energy source, which raises questions about the physiological and metabolic features that make them more competitive in harsh volcanic ecosystems. To address these questions, samples were taken from volcanic strata formed by eruptions from Calbuco Volcano (Chile) in 2015 (tephra) and 1917 (soil). Two carboxydovore members of the Burkholderiaceae family were isolated for further study to elucidate the benefits of carboxydovory for the survival of these …

Sigma1 Inhibitor Suppression Of Adaptive Immune Resistance Mechanisms Mediated By Cancer Cell Derived Extracellular Vesicles, Paola A. Castagnino, Derick A. Haas, Luca Musante, Nathalia A. Tancler, Bach V. Tran, Rhonda Kean, Alexandra R. Steck, Luis A. Martinez, Elahe A. Mostaghel, D. Craig Hooper, Felix J. Kim

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Adaptive immune resistance in cancer describes the various mechanisms by which tumors adapt to evade anti-tumor immune responses. IFN-γ induction of programmed death-ligand 1 (PD-L1) was the first defined and validated adaptive immune resistance mechanism. The endoplasmic reticulum (ER) is central to adaptive immune resistance as immune modulatory secreted and integral membrane proteins are dependent on ER. Sigma1 is a unique ligand-regulated integral membrane scaffolding protein enriched in the ER of cancer cells. PD-L1 is an integral membrane glycoprotein that is translated into the ER and processed through the cellular secretory pathway. At the cell surface, PD-L1 is an immune …

Genome-Wide Profiling Of Trna Modifications By Induro-Trnaseq Reveals Coordinated Changes, Yuko Nakano, Howard Gamper, Henri Mcguigan, Sunita Maharjan, Jiatong Li, Zhiyi Sun, Erbay Yigit, Sebastian Grünberg, Keerthana Krishnan, Nan-Sheng Li, Joseph Piccirilli, Ralph Kleiner, Nicole Nichols, Brian Gregory, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

While all native tRNAs undergo extensive post-transcriptional modifications as a mechanism to regulate gene expression, mapping these modifications remains challenging. The critical barrier is the difficulty of readthrough of modifications by reverse transcriptases (RTs). Here we use Induro-a new group-II intron-encoded RT-to map and quantify genome-wide tRNA modifications in Induro-tRNAseq. We show that Induro progressively increases readthrough over time by selectively overcoming RT stops without altering the misincorporation frequency. In a parallel analysis of Induro vs. a related RT, we provide comparative datasets to facilitate the prediction of each modification. We assess tRNA modifications across five human cell lines and …

Development And Characterization Of Cd44-Targeted X-Aptamers With Enhanced Binding Affinity For Cancer Therapeutics, Hongyu Wang, Weiguo He, Miguel-Angel Elizondo-Riojas, Xiaobo Zhou, Tae Jin Lee, David G Gorenstein

Faculty, Staff and Student Publications

CD44, a pivotal cell surface molecule, plays a crucial role in many cellular functions, including cell-cell interactions, adhesion, and migration. It serves as a receptor for hyaluronic acid and is involved in lymphocyte activation, recirculation, homing, and hematopoiesis. Moreover, CD44 is a commonly used cancer stem cell marker associated with tumor progression and metastasis. The development of CD44 aptamers that specifically target CD44 can be utilized to target CD44-positive cells, including cancer stem cells, and for drug delivery. Building on the primary sequences of our previously selected thioaptamers (TAs) and observed variations, we developed a bead-based X-aptamer (XA) library by …

Exploring Teachers' Initial Perceptions Of Corpus Linguistics And Their Readiness To Incorporate Corpora In Classroom Instruction: A Qualitative Analysis, Misnawati Misnawati, Yusriadi Yusriadi, Zul Astri, Aswin Abbas, Asbar Asbar

The Qualitative Report

The integration of corpora into language teaching appears to be lacking, raising the question of whether this omission is due to teachers intentionally choosing not to use corpora in their classes or a lack of awareness and knowledge about these tools. This study of teachers in Indonesia aimed to explore two research questions: (a) what are the teachers' initial perceptions regarding corpus linguistics, and (b) do the teachers intend to integrate corpora into classroom instruction? Fifteen secondary and tertiary-level teachers participated in this qualitative study. Researchers gave the teachers a brief presentation on corpora to develop their Corpus Literacy (CL) …

Sara Above, Sothear Nget

Journal of Southeast Asian American Education and Advancement

This is a creative literary work from Sothear Nget.

Volume 38-2 Complete Issue, C. Nicholas Raphael

The Geographical Bulletin

Volume 38-2 Complete Issue

Charcoal Making: An Element Of Antiguan Folk Culture, Douglas Heffington

The Geographical Bulletin

Antigua, in the Caribbean Lesser Antilles, has a rich cultural history. The residuals of a monoculture agriculture involving sugar cane (Saccharum ssp.) cultivation are seen everywhere, including a large ethnic population of African descent. Blacks brought to the island as slave labor since the late 1600s have contributed significantly to Antiguan folk culture, including active participation in the cottage industry of charcoal making and the maintenance of the associated material culture. This paper is the documentation of a folk industry before it is lost to the inevitable encroachment of modernization.

Of Landscapes And Nightmares: The Geography Of Fictional Horror, Michelle K. Smith

The Geographical Bulletin

This paper examines the role of landscape, place, and setting in the horror genre. A brief history of horror is followed by an examination of the trends and changes that have occurred in horror literature over time. Explanations for these trends are offered. Two-hundred horror stories from 1895 to the present are categorized into the three basic genre subtypes (supernatural, psychological, or other), and their associated landscape settings are identified. The city has been and remains the most popular setting in horror fiction, followed by the small town setting, the rural setting, and the suburban setting. All are associated with …

Eng 1002g-001 College Composition Ii Argument And Critical Inquiry, Amie Whittemore

Fall 2024

No abstract provided.

Kajian Risiko Kesehatan Pajanan Bahaya Kimia Benzene, Toluene, Dan Xylene Pada Pekerja Laboratorium Lubricant Pt X, Muhammad Reyhan Ahadin Pratama, Mila Tejamaya

National Journal of Occupational Health and Safety

Lubricant laboratory pose various occupational safety and health hazards to their workers. Exposure to chemical hazards can occur through multiple routes and can lead to both acute and chronic health risks for laboratory workers. This study aims to analyze the health risks associated with exposure to benzene, toluene, and xylene (BTX) among lubricant laboratory workers at PT X. The study was conducted from February to June 2024 using a descriptive analytical research design with the chemical health risk assessment method from the Department of Safety and Health Malaysia (DOSH) 2018. Data collection techniques were employed quantitatively through personal exposure measurements …

Social Jetlag Alters Markers Of Exercise-Induced Mitochondrial Adaptations In The Heart, Michael B. Dial, Elias M. Malek, Austin R. Cooper, Greco A. Neblina, Nikoleta I. Vasileva, Graham Mcginnis

Kinesiology and Nutrition Sciences Faculty Research

Social jetlag (SJL) represents the behavioral misalignment of sleep and wake times on work days and free days, and potently disrupts the circadian rhythm. SJL affects up to 70% of the population worldwide and is associated with increased risk for many cardiometabolic diseases. Animal models of acute SJL have shown disruption in locomotor activity and expression of clock genes in select tissues, its impact on the heart remains unclear. The purpose of this study was to investigate the effects of prolonged SJL (6 weeks), on activity rhythms, and the impact on exercise-induced adaptations in the heart. Male mice (n …

Reducing Alarm Fatigue, Christina Smith

2025

Alarm fatigue refers to the phenomenon of excessive alarms in the healthcare system leading to staff ignoring or not hearing alarms that need clinical intervention (Bosma & Christopher, 2023). Healthcare staff experiencing alarm fatigue and desensitization leads to patient harm events up to and including death (Dee et al., 2022). Several interventions have proven effective to reduce non-actionable alarms or alarms that do not require action by the clinician. Combining these evidence based interventions into a bundle of nurse led interventions provides increased effectiveness in reducing alarm fatigue. This evidence-based practice (EBP) project aimed to evaluate the effectiveness of bundle …

Contemporary Views Of Spiritual And Theological Reflection (2013-2023) Compared To Forty Years Ago: Analysis Of 32 Texts, Chris Brouillard-Coyle, Des Mcenaney, Joselin Zak, Thomas St. James O’Connor

Consensus

What are contemporary views on spiritual and theological reflection? We answer this question using a hermeneutical research method analyzing 32 texts from the current situation. The data indicate five themes: 1) experiences as sources for spiritual/theological reflection, 2) meaning making as key component for spiritual/theological reflection, 3) growth in spiritual reflection and overlap with theological reflection, 4. some flexible methods; many without explicit method, and 5) spiritual but not religious. Discussion, limitations, and areas for future research are provided.

Liminal Transformational Pastoral Leadership: A Case Study God’S Story, Our Story: Living In Times Of Change, Kara Carter

Consensus

No abstract provided.

Correlates Of Inaccuracy In Reporting Of Energy Intake Among Persons With Multiple Sclerosis, Stephanie L Silveira, Brenda Jeng, Barbara A Gower, Gary R Cutter, Robert W Motl

Faculty, Staff and Student Publications

BACKGROUND/OBJECTIVES: Persons with multiple sclerosis (MS) are interested in diet as a second-line approach for disease management. This study examined potential variables that correlate with inaccuracy of self-reported energy intake (EI) in adults with MS.

METHODS: Twenty-eight participants completed two assessment appointments within a 14-day period that included a standard doubly labeled water (DLW) protocol for estimating total energy expenditure (TEE). The participants reported their EI using the Automated Self-Administered 24 h (ASA24) Dietary Assessment Tool. The primary variables of interest for explaining the discrepancy between TEE and ASA24 EI (i.e., inaccuracy) included cognition (processing speed, visuospatial memory, and verbal …

Vulnerability And Adaptation In Flood-Prone Ecosystems Of Bangladesh: A Case Study Of Rice Farming Households, Mohammad Chhiddikur Rahman, Md Abdur Rouf Sarkar, Md Jahangir Kabir, Md Shajedur Rahaman, Jatish C. Biswas, Md Abdullah Aziz, Mohammad Ariful Islam, Md Abdullah Al Mamun, Niaz Md Farhat Rahman, Andrew M. Mckenzie

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Floods in Bangladesh significantly impact rice production, a vital element of food security. While regional flood effects have been extensively studied, the specific impacts on rice, the country's primary staple, remain underexplored. This study assesses the effects of floods on rice production, availability, and prices, alongside identifying household vulnerabilities and adaptation strategies. Using both quantitative and qualitative data from secondary sources and interviews with farmers, we analyzed how floods affect rice cultivation and market dynamics. Our findings showed that floods predominantly affect wet season Aman rice, temporarily disrupting cultivation, national yield, and market prices. However, the adoption of stress-resistant varieties …

A Comprehensive Quality Improvement Program To Improve Intubation Performance In Critical Care Transport, Andrew P. Reimer

Faculty Scholarship

Objective: Advanced airway management is a primary skill critical care transport teams provide. There are several measures of performance for airway management that can be tracked and improved through quality improvement initiatives. The purpose of this project was to improve first-pass intubation success rates and the associated Definitive Airway Sans Hypoxia/Hypotension on First Attempt (DASH-1A) metric—definitive airway without hypoxia or hypotension. Methods: A multiyear quality improvement initiative was undertaken. Best practices from the literature were identified and implemented through the Institute for Healthcare Improvement Model for Improvement using a plan-do-study-act cycle approach. Improvement cycles included airway training in a cadaver …