Digital Commons Network^™

Single-Cell Analysis Identifies Ifi27l2a As A Gene Regulator Of Microglial Inflammation In The Context Of Aging And Stroke In Mice, Gab Seok Kim, Elisabeth Harmon, Manuel C Gutierrez, Sodam Kim, Lauren Vance, Haven Burrous, Jessica M Stephenson, Anjali Chauhan, Anik Banerjee, Zachary Wise, Andrea Doan, John Ahn, Ting Wu, Jesus Bautista-Garrido, Juneyoung Lee, Chunfeng Tan, Joo Eun Jung, Louise D Mccullough, Joshua D Wythe, Sean P Marrelli

Faculty, Staff and Student Publications

Inflammation is a significant driver of ischemic stroke pathology in the brain. To identify potential regulators of inflammation, we performed single-cell RNA sequencing (scRNA-seq) of young and aged mouse brains following stroke and found that interferon alpha-inducible protein 27 like 2 A (Ifi27l2a) was significantly up-regulated, particularly in microglia of aged brain. Ifi27l2a is induced by interferons for viral host defense and has been linked with pro-inflammatory cellular mechanisms. However, its potential role in neurodegeneration is unknown. Using a combination of cell culture, experimental stroke models in mice, and human autopsy brain samples, we demonstrated that induction of Ifi27l2a occurs …

Research Review: "United States Army Reserve/National Guard Soldiers’ Healthcare Experiences, Attitudes, And Preferences: Differences Based On Deployment Status", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This research review highlights findings from a recent study aimed at better understanding health care preferences of National Guard and Reserves service members. The authors found that found that among 430 USAR/NG service members, the overwhelming majority (83%) reported that their community/private provider has never asked how their military service impacts their health despite 39% of participants indicating that their current health concerns are related to their military service. Additionally, there is no difference between USAR/NG servicemembers who were previously deployed overseas and those who were not in their perception of whether community/private providers can address their military-related health concerns. …

Mapping The Perceived Impacts Of A Social Innovation Program On Women’S Agency And Life Satisfaction, Dina Tbaishat, Lina Qtaishat, Jannik Joseph Eggerman, Catherine Panter-Brick, Rana Dajani

All Works

Introduction Cross-cultural research measuring how women perceive their sense of agency and catalyze social innovation has been limited. We conducted a mixed-methods study to learn about women's agency and life satisfaction, while evaluating the perceived benefits of a social innovation program (We Love Reading), in the UAE which, in 2022, launched a nationwide reading promotion strategy.Methods and results We implemented the Sense of Agency (SoA) scale and Cantril Ladder of Life Scale with a sample of 78 female Emirati students, then conducted two Fuzzy Cognitive Mapping (FCM) sessions with 13 respondents. The FCM sessions helped to develop local definitions of …

Creating An Android-Based Calisthenics Application To Assist Students In Improving Their Physical Fitness, Restyandito, Narendra Poetra Wisnoewardhana, Danny Sebastian

Journal of Informatics and Web Engineering

College students, particularly those heavily involved in coursework, frequently do not prioritize physical fitness. Regular exercise is essential for preserving physical fitness and facilitating demanding academic tasks. Although there are other fitness programs available, such as GYM, jogging, CrossFit, and Yoga, users sometimes fail to make full use of them because the content is confined to exercise videos and descriptions. This matter highlights the progress of the Android application Kali Tech, which specifically concentrates on organizing and documenting calisthenics workouts. This program employs the concept of gamification by utilizing student achievement levels to encourage students to be diligent in doing …

Multimodal Objective Assessment Of Impulsivity In Healthy And Mood Disorder Participants, Bishal Lamichhane, Nidal Moukaddam, Ramiro Salas, Wayne Goodman, Ashutosh Sabharwal

Faculty, Staff and Students Publications

Impulsivity represents an individual's tendency to act on urges without sufficient forethought. Heightened impulsivity is a hallmark of many mental health disorders. Objective impulsivity assessments could improve risk evaluation, diagnosis, and behavioral outcome monitoring in impulsivity-related health disorders. Towards objective impulsivity assessment, in this work, we identify impulsivity correlates in objective measurements, investigate their complementarity, and contrast impulsivity mechanisms across health conditions. We analyzed behavioral tests, heart rate variability (HRV), and fMRI-based brain connectivity in 227 healthy participants and 34 participants with mood disorders. Impulsivity dimensions had complementary correlates in objective measurements, with fMRI providing the strongest correlates. Multimodal assessment …

Mage-A4 Induces Non-Small Cell Lung Cancer And Tumor-Promoting Plasma Cell Accumulation, Dominique Armstrong, Cheng-Yen Chang, Monica J Hong, Linda Green, Yichao Shen, William Hudson, Kelsey E Mauk, Li-Zhen Song, Sheetal Jammi, Benjamin Casal, Brianna Burns, Chad J Creighton, Alexandre Carisey, Xiang H-F Zhang, Neil J Mckenna, Sung Wook Kang, Hyun-Sung Lee, William Decker, David B Corry, Farrah Kheradmand

Faculty, Staff and Students Publications

Adaptive immunity is critical in eliminating tumors, but cancer-intrinsic factors can subvert this function. Melanoma antigen-A4 (MAGE-A4), a cancer-testis antigen, is expressed in solid tumors and correlates with poor survival, but its role in tumorigenesis and antitumor immunity remains unclear. We found that expression of MAGE-A4 was highly associated with the loss of PTEN, a tumor suppressor, in human non–small cell lung cancers (NSCLC). Here, we show that constitutive expression of human MAGE-A4 with Pten loss in mouse airway epithelia results in metastatic adenocarcinoma. Tumors showed distinct enrichment in IgA+ CD138+ CXCR4+ plasma cells (PCs) and increased expression of …

Lived Experiences Of Police Use Of Force In Western Utah, Kenny Augustin

Walden Dissertations and Doctoral Studies

The use of force by police officers toward African Americans has been a tense subject in the United States Although statutory law grants the police officers the right to use force, the level and the type of force used by police officers can be seen as problematic. In this study, the lived experiences of African Americans and police officers’ use of force were explored. The purpose of this phenomenological study was to explore whether the lived experiences of African Americans differ from police officers concerning the use of force in Utah and how fear, trust, and confidence influenced behaviors. A …

Divergence In Cellular Markers Observed In Single-Cell Transcriptomics Datasets Between Cultured Primary Trabecular Meshwork Cells And Tissues, Alice Tian, Sangbae Kim, Hasna Baidouri, Jin Li, Xuesen Cheng, Janice Vranka, Yumei Li, Rui Chen, Vijaykrishna Raghunathan

Faculty, Staff and Students Publications

The trabecular meshwork within the outflow apparatus is critical in maintaining intraocular pressure homeostasis. In vitro studies employing primary cell cultures of the human trabecular meshwork (hTM) have conventionally served as surrogates for investigating the pathobiology of TM dysfunction. Despite its abundant use, translation of outcomes from in vitro studies to ex vivo and/or in vivo studies remains a challenge. Given the cell heterogeneity, performing single-cell RNA sequencing comparing primary hTM cell cultures to hTM tissue may provide important insights on cellular identity and translatability, as such an approach has not been reported before. In this study, we assembled a …

A Comparative Evaluation Of Alectinib For Alk-Positive Non-Small-Cell Lung Cancer: A Systematic Review, Monica Kharat, Harshitha Nookala, Jabez David John, Tirath Patel, Pragnesh Kalyandrug, Sonya Emmanuel, Anaya Noor, Dhruv Jignesh Kumar Halani, Abhishek Goyal, Bharathi Gadad

School of Medicine Publications

Background:

Lung cancer, a significant global health challenge, notably the non-small-cell lung cancer (NSCLC) subtype, is a topic of utmost importance. The continuous advancements in NSCLC treatment, especially in the context of anaplastic lymphoma kinase (ALK)-positive NSCLC, are of great interest. A thorough review of alectinib’s comparative efficacy and safety with other treatment modalities is a crucial step, and the role of clinicians and surgeons is integral in optimizing patient care. This review can also inform neoadjuvant therapies and enhance surgical education, facilitating more informed decision-making processes between surgeons and patients.

Methods:

This comprehensive systematic review results from rigorous screening. …

Identification Of Distinct Stool Metabolites In Women With Endometriosis For Non-Invasive Diagnosis And Potential For Microbiota-Based Therapies, Chandni Talwar, Goutham Venkata Naga Davuluri, Abu Hena Mostafa Kamal, Cristian Coarfa, Sang Jun Han, Surabi Veeraragavan, Krishna Parsawar, Nagireddy Putluri, Kristi Hoffman, Patricia Jimenez, Scott Biest, Ramakrishna Kommagani

Faculty, Staff and Students Publications

Background: Endometriosis, a poorly studied gynecological condition, is characterized by the presence of ectopic endometrial lesions resulting in pelvic pain, inflammation, and infertility. These associated symptoms contribute to a significant burden, often exacerbated by delayed diagnosis. Current diagnostic methods involve invasive procedures, and existing treatments provide no cure.

Methods: Microbiome-metabolome signatures in stool samples from individuals with and without endometriosis were determined using unbiased metabolomics and 16S bacteria sequencing. Functional studies for selected microbiota-derived metabolites were conducted in vitro using patient-derived cells and in vivo by employing murine and human xenograft pre-clinical disease models.

Findings: We discovered a unique bacteria-derived …

The Mirror Of Desire Unbidden: Retrieving The Imago Dei In Tolkien And Late Medieval English Literature (2024) By Giovanni Carmine Costabile, Łukasz Neubauer

Journal of Tolkien Research

Book Review, by Łukasz Neubauer, of The Mirror of Desire Unbidden: Retrieving the Imago Dei in Tolkien and Late Medieval English Literature (2024) by Giovanni Carmine Costabile

Tamil Cinema, Perianayagam Jesudoss

Communication Research Trends

No abstract provided.

Classical Ballet: The Progressive Preservation Of Tradition, Caroline Peacock

Quest

Research Essay

Research in progress for ENGL 1302: Composition II

Faculty Mentor: Lisa Roy-Davis, PhD

I am pleased to introduce Caroline Peacock’s excellent work “Classical Ballet: The Progressive Preservation of Tradition,” a research essay she wrote for my English 1302 class in the fall 2023 semester. Adapted from Bruce Ballenger’s textbook, The Curious Writer, the Research Essay assignment encourages students to foreground the role of inquiry by narrating their questions and how their sources address and extend those questions. When students prioritize questions over answers, their writing then demonstrates the value of “thinking on the page,” or the forward …

Medical Negligence (Anthony R. Barrowclough & Harry L. Nathan, 1957), Melvin M. Belli

Florida Law Review

No abstract provided.

The Law Of Admirality (Grant Gilmore & Charles L. Black, Jr., 1957), Thomas C. Macdonald Jr.

Florida Law Review

No abstract provided.

Effect Of Multiple Application Of Chlorhexidine Chips In Peri-Implantitis Treatment: A Systematic Review, Kirollos Semary, Kade Janes, Shilpa Bhandi, Shankargouda Patil, Frank Licari

Annual Research Symposium

No abstract provided.

Gingival Hyperplasia In Orthodontic Patients, Mohamed Ali Basha, Joseph Cheever, Man Hung

Annual Research Symposium

No abstract provided.

Counter-Intuitive Links Between Cave Genesis And Subaerial Stream Dynamics In The Têt Valley–Lachambre Network, Eastern Pyrenees, France, Stéphane Jaillet, Gabriel Hez, Marc Calvet, Magali Delmas, Edwige Pons-Branchu, Yanni Gunnell

International Journal of Speleology

The Lachambre cave network (Eastern Pyrenees, France) is well suited to studying the interaction between vertical successions of low-gradient cave passages in the limestone and chronosequences of fluvial terraces in the adjacent valley. Investigations here focus on cave passages striking parallel to the Têt River, and on their topographic, geomorphological, sedimentological and geochronological relationship with the two youngest generations of Pleistocene fluvial terrace, T2 and T1. Results reveal that the longitudinal profiles of the terraces and modern thalweg (1.5–3%) are ten times steeper than the profiles of the subterranean passages (0.1–0.3%), which display typical characteristics of water table caves. The …

Optimal Investment In An Energy Storage System, Marta Castellini, Chiara D'Alpaos, Fulvio Fontini, Michele Moretto

Fondazione Eni Enrico Mattei Working Papers

Renewable energy production plays a crucial role in the energy transition. However, many renewable energy sources (RES) are intermittent, and there is often a mismatch between energy production and consumption, which can be partially solved by storage. In this paper, we investigate the investment decision in a photovoltaic (PV) power plant coupled with a Battery Energy Storage System (BESS), namely an Energy Storage System (ESS). We aim to investigate the relationship between the net present value (NPV) of the investment and the technical implications related to the maximum amount of energy to be stored while also accounting for the impact …

Macbeth

Theatre and Performance Studies Programs

What happens when people with power go unchecked, especially when that power is driven by desires and emotions? Is morality lost? What are the repercussions of tyranny? Kennesaw State University’s Department of Theatre and Performance Studies (TPS) will examine those questions as they present “Macbeth” running Feb. 13-23 at the Stillwell Theater. TPS Faculty and Director Marlon Andrew Burnley says that the play “explores the destructive power of ambition, the fragility of the human soul, and the consequences of choices made in pursuit of power.”

Eng 3008-001 Digital Writing And Multimodal Texts, Rachael Ryerson

Fall 2024

No abstract provided.

The Chanticleer, 2025-02-13, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

The Indiana Statesman, February 13, 2025, Indiana State University

Student Newspaper

Scan & Pay: parking payments made easierpayments easier; Department of Biology “3 billion missing birds”; Japanese Club hosts “Chocolate Day”

February 14, 2025, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Vista: February 13, 2025, University Of San Diego

USD Vista (1965-)

No abstract provided.

Kenyon Collegian - February 13, 2025

The Kenyon Collegian

No abstract provided.

Impact Of Drug Addiction On Oral Health: Unveiling The Link Between Substance Abuse, Rahi [email protected], Kamran Awan

Annual Research Symposium

No abstract provided.

The Efficacy Of Inspiratory Muscle Training Post Covid: A Systematic Review, Robert Dekerlegand, Sydney Brannen, Olivia Bunch, Amrit Deo, Erin Dopke, Kayleigh Moreland

Department of Physical Therapy Posters

Introduction

• Fatigue and dyspnea can persist post COVID infection and negatively impact both functional capacity and quality of life (QOL).^1,2
• Residual pulmonary impairments and/or inspiratory muscle dysfunction associated with COVID infection contribute to these symptoms.^2,3
• Ventilatory demands exceeding the capacity of the inspiratory muscles can exacerbate these symptoms accentuating activity limitations that restrict participation in life roles.
• As symptom-limited exercise and QOL are related to inspiratory muscle function post COVID,^4,5 inspiratory muscle training (IMT) may improve rehabilitation outcomes.³
• The purpose of this systematic review was to determine the potential efficacy of IMT in individuals post-COVID.

Towards More Sustainable Oceans: A Review Of The Pressing Challenges Posed By Marine Plastic Litter, Peter Yang

Faculty Scholarship

Marine littering is a global challenge and a significant threat to a sustainable planet, requiring comprehensive and effective mechanisms to address it in a comprehensive manner. This study reports on a bibliometric analysis that has identified the extent to which the topic has been explored in the international literature, by focusing on geographical scope, the emphasis on (micro)plastic litter and on policy measures. Additionally, as a complement to the assessment of the recent literature on marine plastic litter, this study reviews some case studies, identifying some trends on how to cope with this problem. The findings underscore the imperative for …

Arrhythmogenic Right Ventricular Cardiomyopathy: A Comprehensive Review, Taha Shaikh, Darren Nguyen, Jasmine Dugal, Michael Dicaro, Brianna Yee, Nazanin Houshmand, Kachon Lei, Ali Namazi

Department of Internal Medicine Faculty Research

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by structural abnormalities, arrhythmias, and a spectrum of genetic and clinical manifestations. Clinically, ARVC is structurally distinguished by right ventricular dilation due to increased adiposity and fibrosis in the ventricular walls, and it manifests as cardiac arrhythmias ranging from non-sustained ventricular tachycardia to sudden cardiac death. Its prevalence has been estimated to range from 1 in every 1000 to 5000 people, with its large range being attributed to the variability in genetic penetrance from asymptomatic to significant burden. It is even suggested that the prevalence is underestimated, as the presence of genotypic mutations …