Digital Commons Network^™

A Constitutional Mandate To Adopt Avs, Kevin Frazier

Washington and Lee Law Review Online

The rapid advancement of autonomous vehicle (“AV”) technology presents a unique opportunity to enhance public safety by drastically reducing road fatalities. Despite significant private sector investment and demonstrated improvements in AV performance, public adoption and integration remain hindered by regulatory gaps and societal skepticism. This Article argues that the federal government has an affirmative obligation, rooted in the doctrine of a right to effective government, to champion the adoption of technologies like AVs that meaningfully promote the general welfare.

Drawing on the Preamble’s mandate to advance the general welfare and lessons from the transition from the Articles of Confederation to …

Plight Of The American Innovator, David R. Soucy

Chicago-Kent Journal of Intellectual Property

The American innovator is at risk. Our U.S. patent system unfortunately favors the speculators over the innovators. In the fight against questionable patent suits brought by non-practicing entities (i.e., patent trolls), those disagreements have become a one-sided affair in favor of the investor. This unjust circumstance arises due to the immunity patent trolls have from the innovator’s patents. A frustrating predicament for an innovator who has often made substantial investments in protecting his or her technology that go for naught in a dispute with an entity who does not put products into the stream of commerce. Now § 285 of …

Organic Websites: Certification Of Ai-Generated Or Human-Written Content On The Internet, Andrew W. Torrance, Bill Tomlinson

Chicago-Kent Journal of Intellectual Property

This paper proposes the development of a certification system analogous to the standards used in organic food labeling, designed to distinguish websites based on the proportion of human-written versus AI-generated content. In an era where AI plays an increasingly prominent role in content creation, this system would provide transparency for consumers and uphold fair competition in digital markets. The certification would allow website creators to present verifiable evidence of their content’s provenance, ranging from entirely human-made, to a mix of human and AI contributions, to fully AI-generated content. Additionally, this paper explores the legal and policy frameworks necessary for implementing …

Cover And Contents

Turkish Journal of Earth Sciences

No abstract provided.

Classification Of Asia Minor Marbles Based On Crystal Size For Archaeometric Assignment, Ramazan Hacimustafaoğlu, Hakan Elçi̇

Turkish Journal of Earth Sciences

This study was carried out to determine the range of crystal sizes of Asia Minor marbles and to classify the marbles accordingto crystal size. Asia Minor marbles have been used as building stones since ancient times. The literature already includes studies on theircrystal sizes; however, different studies performed on marbles of the same locality have reported different crystal size classes, which hascaused complexity. To eliminate this complexity, this study used multidirectional petrographic analyses on the eight known Asia Minormarbles. Thin sections were photographed under a polarizing microscope, and the crystal sizes of the samples were measured usingcomputerized image analysis. An …

Petrography, Electron Paramagnetic Resonance, Geochemistry, And Sr-C-O Isotope Datafor Provenance Studies Of The Ancient Marmor Iassense In Kıyıkışlacık(Muğla Region), Türkiye, Namik Aysal, Emre Erdem, Nurullah Hani̇lçi̇, Tali̇p Güngör, Si̇nan Öngen, İsak Yilmaz, Fulya Uzun, Davut Laçi̇n, İpek Deni̇z Yildirim

Turkish Journal of Earth Sciences

The Marmor Iassense (Iasos marble, Marmor Carium) banded marbles, produced from the Kızılağaç Formation near thevillage of Kıyıkışlacık, have been favorite marbles from ancient times to the present day with their colors and patterns. During theRoman and Byzantine periods, they were preferred as decorative stones for many important buildings in İstanbul, such as the HagiaSophia, Chora Monastery (Kariye Mosque), and Church of the Holy Apostles, as well as San Vitale in Ravenna and other buildingsthroughout the Mediterranean region. They were used in wall coverings, flooring, columns, and mosaics. These marbles contain redand gray-white alternating folded layers of different thicknesses. They …

Characterization Of Stone Materials From The Roman Caracalla Bath In Ancyra, Zeynep Tanriverdi̇, Ali̇ Akin Akyol, Yusuf Kağan Kadioğlu

Turkish Journal of Earth Sciences

The Roman Caracalla Bath was built during the reign of Roman Emperor Caracalla (circa AD 200). Today it exists only inthe form of wall remnants at the foundation level and functions as an open-air museum. It is located on a mound approximately 2.5-mhigh along Ulus’s Çankırı Street in Ankara. This research paper aims to identify the characterization and implications for provenance ofthe stone materials used in the construction of the bath by using mineralogical, petrographic, and geochemical definitions. The resultsobtained from the stone materials also provide guidance for restoration and reinforcement of the bath. In this study, the 13 stone …

Digital Documentation Of A Byzantine Rock-Carved Structure In Konya:Kiriakon Monastery, Sille, Hasan Bi̇lgehan Maki̇neci̇, İlker Mete Mi̇mi̇roğlu, Esra Yaldiz, Hakan Karabörk

Turkish Journal of Earth Sciences

Digital documentation methods enable the acquisition of viable data to preserve cultural heritage and its accurate transferto future generations. Unmanned aerial vehicle (UAV) and terrestrial laser scanning (TLS) equipment are technical tools that haveessential functions in the three-dimensional (3D) modeling of structures of historical importance. In the geographic referencing andvisualization of historical structures with their surroundings, UAVs are often used, and for the visualization of the interior spaces ofstructures as a whole, TLS is popular. The Kiriakon Monastery, a rock-carved, cross-in-square, four-supports simple provincial typeof church, and several different structures around it within the borders of Sille in Konya Province …

2025-02-20 Education Abroad Powerpoint Presentation, Morehead State University. Faculty Senate.

Faculty Senate Records

A PowerPoint presentation by Jason Adkins of the International Studies Program on Education Abroad submitted on February 20, 2025.

Automated Detection Of Reduced Ejection Fraction Using An Ecg-Enabled Digital Stethoscope: A Large Cohort Validation, Ling Guo, Gregg S. Pressman, Spencer N. Kieu, Scott B. Marrus, George Mathew, John Prince, Emileigh Lastowski, Rosalie V. Mcdonough, Caroline Currie, John N. Maidens, Hussein Al-Sudani, Evan Friend, Deepak Padmanabhan, Preetham Kumar, Edward Kersh, Subramaniam Venkatraman, Salima Qamruddin

Einstein Health Papers

BACKGROUND: Asymptomatic left ventricular systolic dysfunction (ALVSD) affects 7 million globally, leading to delayed diagnosis and treatment, high mortality, and substantial downstream health care costs. Current detection methods for ALVSD are inadequate, necessitating the development of improved diagnostic tools. Recently, electrocardiogram-based algorithms have shown promise in detecting ALVSD.

OBJECTIVES: The authors developed and validated a convolutional neural network (CNN) model using single-lead electrocardiogram and phonocardiogram inputs captured by a digital stethoscope to assess its utility in detecting individuals with actionably low ejection fractions (EF) in a large cohort of patients.

METHODS: 2,960 adults undergoing echocardiography from 4 U.S. health care …

Honors Faculty Research Talks Crystal Jiang, Ph.D, Crystal Jiang

Honors Programs

No abstract provided.

Lowell Hardin: Mentor Extraordinaire, Larry L. Murdock, Thomas W. Hertel, Gebisa Ejeta

Purdue University Press Books

Lowell Stewart Hardin (1917–2015), an Indiana farm boy who became an enormously influential international agriculturalist, made the world a better place for the poor and the hungry on this earth. For seventeen years he led the Ford Foundation’s agricultural development efforts, contributing to the Green Revolution. He helped to found and guide international agriculture research centers in Africa, Asia, and Latin America. He inspired others to get involved and opened doors for them. He taught by example, gave others credit, and always stepped back, avoiding the limelight himself. In this volume, twenty-two people who knew him well share stories of …

Semaglutide And Nonarteritic Anterior Ischemic Optic Neuropathy, Cindy X Cai, Michelle Hribar, Sally Baxter, Kerry Goetz, Swarup S Swaminathan, Alexis Flowers, Eric N Brown, Brian Toy, Benjamin Xu, John Chen, Aiyin Chen, Sophia Wang, Cecilia Lee, Theodore Leng, Joshua R Ehrlich, Andrew Barkmeier, Karen R Armbrust, Michael V Boland, David Dorr, Danielle Boyce, Thamir Alshammari, Joel Swerdel, Marc A Suchard, Martijn Schuemie, Fan Bu, Anthony G Sena, George Hripcsak, Akihiko Nishimura, Paul Nagy, Thomas Falconer, Scott L Duvall, Michael Matheny, Benjamin Viernes, William O'Brien, Linying Zhang, Benjamin Martin, Erik Westlund, Nestoras Mathioudakis, Ruochong Fan, Adam Wilcox, Albert Lai, Jacqueline C Stocking, Sahar Takkouche, Lok Hin Lee, Yangyiran Xie, Izabelle Humes, David B Mccoy, Mohammad Adibuzzaman, Raymond G Areaux, William Rojas-Carabali, James Brash, David A Lee, Nicole G Weiskopf, Louise Mawn, Rupesh Agrawal, Hannah Morgan-Cooper, Priya Desai, Patrick B Ryan

Faculty, Staff and Student Publications

Importance

Semaglutide, a glucagonlike peptide-1 receptor agonist (GLP-1RA), has recently been implicated in cases of nonarteritic anterior ischemic optic neuropathy (NAION), raising safety concerns in the treatment of type 2 diabetes (T2D).

Objective

To investigate the potential association between semaglutide and NAION in the Observational Health Data Sciences and Informatics (OHDSI) network.

Design, Setting, and Participants

This was a retrospective study across 14 databases (6 administrative claims and 8 electronic health records). Included were adults with T2D taking semaglutide, other GLP-1RA (dulaglutide, exenatide), or non–GLP-1RA medications (empagliflozin, sitagliptin, glipizide) from December 1, 2017, to December 31, 2023. The incidence proportion …

Gender And Sexuality: Lgbtq+ Youth Experiences, Lauren B. Mcinroy, Kathryn Macapagal, Oliver Beer, Claire Coyne

School of Health Professions

Internet-enabled information and communication technologies (ICTs) pose simultaneous risks and opportunities for contemporary lesbian, gay, bisexual, transgender, queer, or otherwise sexual and/or gender diverse (LGBTQ+) adolescents and young adults—a population who may be particularly active users of ICTs. This chapter provides a brief overview of LGBTQ+ youths’ lived experiences and barriers to care, followed by a review of extant knowledge regarding the ICT experiences of this population with a particular focus on the context of the United States. Significant gaps in knowledge regarding LGBTQ+ youths’ engagement with ICTs persist and proposed areas of inquiry for future research are provided. As …

Erythritol, Erythronate, And Cardiovascular Outcomes In Older Adults In The Aric Study, Layla A Abushamat, Bing Yu, Ron C Hoogeveen, Caroline Sun, Chao Cheng, Sean M Hartig, Mark A Herman, Ashok Balasubramanyam, Jane Eb Reusch, Elizabeth Selvin, Chiadi E Ndumele, Vijay Nambi, Christie M Ballantyne

Faculty, Staff and Student Publications

BACKGROUND: Circulating erythritol, an endogenously produced metabolite and an artificial sweetener, is associated with cardiovascular outcomes.

OBJECTIVES: The authors assessed associations of erythritol and its downstream metabolite, erythronate, with cardiovascular risk factors and events in older adults in the ARIC (Atherosclerosis Risk In Communities) study (visit 5, 2011-2013).

METHODS: We included 4,006 participants without prevalent cardiovascular disease and with metabolomic profiling. Erythritol and erythronate were measured by mass spectrometry. We analyzed associations of log-transformed erythritol and erythronate with cardiovascular risk factors and events using Cox proportional hazard models.

RESULTS: Participants in the highest tertiles of erythritol or erythronate were older, …

Zika Virus Ns1 Drives Tunneling Nanotube Formation For Mitochondrial Transfer And Stealth Transmission In Trophoblasts, Rafael T Michita, Long B Tran, Steven J Bark, Deepak Kumar, Shay A Toner, Joyce Jose, Indira U Mysorekar, Anoop Narayanan

Faculty, Staff and Students Publications

Zika virus (ZIKV) is unique among orthoflaviviruses in its vertical transmission capacity in humans, yet the underlying mechanisms remain incompletely understood. Here, we show that ZIKV induces tunneling nanotubes (TNTs) in placental trophoblasts which facilitate transfer of viral particles, proteins, mitochondria, and RNA to neighboring uninfected cells. TNT formation is driven exclusively via ZIKV non-structural protein 1 (NS1). Specifically, the N-terminal 1-50 amino acids of membrane-bound ZIKV NS1 are necessary for triggering TNT formation in host cells. Trophoblasts infected with TNT-deficient ZIKV

Antibiotic-Induced Loss Of Gut Microbiome Metabolic Output Correlates With Clinical Responses To Car T-Cell Therapy, Rishika Prasad, Abdur Rehman, Lubna Rehman, Faezeh Darbaniyan, Viktoria Blumenberg, Maria-Luisa Schubert, Uria Mor, Eli Zamir, Sabine Schmidt, Tomo Hayase, Chia-Chi Chang, Lauren Mcdaniel, Ivonne Flores, Paolo Strati, Ranjit Nair, Dai Chihara, Luis E Fayad, Sairah Ahmed, Swaminathan P Iyer, Michael Wang, Preetesh Jain, Loretta J Nastoupil, Jason Westin, Reetakshi Arora, Joel Turner, Fareed Khawaja, Ranran Wu, Jennifer B Dennison, Meghan Menges, Melanie Hidalgo-Vargas, Kayla Reid, Marco L Davila, Peter Dreger, Felix Korell, Anita Schmitt, Mark R Tanner, Richard E Champlin, Christopher R Flowers, Elizabeth J Shpall, Samir Hanash, Sattva S Neelapu, Michael Schmitt, Marion Subklewe, Johannes Francois-Fahrmann, C K Stein-Thoeringer, Eran Elinav, Michael D Jain, Eiko Hayase, Robert R Jenq, Neeraj Y Saini

Faculty, Staff and Student Publications

Antibiotic (ABX)–induced microbiome dysbiosis is widespread in oncology, adversely affecting outcomes and side effects of various cancer treatments, including immune checkpoint inhibitors and chimeric antigen receptor T-cell (CAR-T) therapies. In this study, we observed that prior exposure to broad-spectrum ABXs with extended anaerobic coverage such as piperacillin-tazobactam and meropenem was associated with worse anti-CD19 CAR-T therapy survival outcomes in patients with large B-cell lymphoma (N = 422) than other ABX classes. In a discovery subset of these patients (n = 67), we found that the use of these ABXs was in turn associated with substantial dysbiosis of gut microbiome function, …

Aif3 Splicing Variant Elicits Mitochondrial Malfunction Via The Concurrent Dysregulation Of Electron Transport Chain And Glutathione-Redox Homeostasis, Mi Zhou, Shuiqiao Liu, Yanan Wang, Bo Zhang, Ming Zhu, Jennifer E Wang, Veena Rajaram, Yisheng Fang, Weibo Luo, Yingfei Wang

Faculty, Staff and Student Publications

Genetic mutations in apoptosis-inducing factor (AIF) have a strong association with mitochondrial disorders; however, little is known about the aberrant splicing variants in affected patients and how these variants contribute to mitochondrial dysfunction and brain development defects. We identified pathologic AIF3/AIF3-like splicing variants in postmortem brain tissues of pediatric individuals with mitochondrial disorders. Mutations in AIFM1 exon-2/3 increase splicing risks. AIF3-splicing disrupts mitochondrial complexes, membrane potential, and respiration, causing brain development defects. Mechanistically, AIF is a mammalian NAD(P)H dehydrogenase and possesses glutathione reductase activity controlling respiratory chain functions and glutathione regeneration. Conversely, AIF3, lacking these activities, disassembles mitochondrial complexes, increases …

A Protocol To Purify Human Mediator Complex From Freestyle 293-F Cells, Hui-Chi Tang, Kuang-Lei Tsai, Ti-Chun Chao

Faculty, Staff and Student Publications

The Mediator, a multi-subunit protein complex in all eukaryotes, comprises the core mediator (cMED) and the CDK8 kinase module (CKM). As a molecular bridge between transcription factors (TFs) and RNA polymerase II (Pol II), the Mediator plays a critical role in regulating Pol II-dependent transcription. Considering its large size and complex composition, conducting in vitro studies on the Mediator complex is challenging, especially when isolating the intact and homogeneous complex from human cells. Here, we present a method to purify the intact CKM-cMED complex from FreeStyle 293-F cells (293-F cells), which offers advantages for performing large-scale protein purification. To isolate …

Membrane Lipids Augment Cell Envelope Stress Signaling Via The Madrs System To Defend Against Antimicrobial Peptides And Antibiotics In Enterococcus Faecalis, William R Miller, April Nguyen, Kavindra V Singh, Samie Rizvi, Ayesha Khan, Sam G Erickson, Stephanie L Egge, Melissa Cruz, An Q Dinh, Lorena Diaz, Philip C Thornton, Rutan Zhang, Libin Xu, Danielle A Garsin, Yousif Shamoo, Cesar A Arias

Faculty, Staff and Student Publications

Enterococci have evolved resistance mechanisms to protect their cell envelopes against bacteriocins and host cationic antimicrobial peptides (CAMPs) produced in the gastrointestinal environment. Activation of the membrane stress response has also been tied to resistance to the lipopeptide antibiotic daptomycin. However, the actual effectors mediating resistance have not been elucidated. Here, we show that the MadRS (formerly YxdJK) membrane antimicrobial peptide defense system controls a network of genes, including a previously uncharacterized 3-gene operon (madEFG) that protects the Enterococcus faecalis cell envelope from antimicrobial peptides. Constitutive activation of the system confers protection against CAMPs and daptomycin in the absence of …

Preserving Diversity In The Wake Of Students For Fair Admissions, Inc.: Historical Lessons From The United States And India, Tyler Dunne

San Diego International Law Journal

Following the ban on considering race in higher education admissions under Students for Fair Admissions, Inc. v. President & Fellows of Harvard College, concerns have emerged over maintaining racial diversity in college classrooms. This analysis offers a comparative perspective, exploring the history and methodologies of affirmative action in the United States and India to identify effective strategies for promoting diversity in U.S. universities. Recommended approaches include top percent programs, socioeconomic-based affirmative action, test-optional or test-blind policies, race-based recruiting, removing legacy preferences, and holistic student reviews. By implementing these strategies, universities can still work toward their diversity goals despite the …

Generative Ai And Disinformation: Analyzing China’S Strategy Amidst U.S. Investment And Export Controls, Liana Edgar

San Diego International Law Journal

The rapid evolution of artificial intelligence (AI) technologies has ushered in a new era of technological, economic, and legal transformation. As economies expand and technology continues to evolve, AI has ignited a competition for technological supremacy, commonly known as the “AI Race.” China and the United States have taken center stage, amplifying their longstanding technological rivalry within the realm of AI. This analysis delves into China’s regulatory approach to generative AI, its strategic positioning in the ongoing AI race, and its influence operations, specifically the dissemination of disinformation. It also examines U.S. strategies for controlling AI technological advancement in China …

A Comprehensive Survey Of Data-Driven Solutions For Lorawan: Challenges And Future Directions, Poonam Maurya, Abhishek Hazra, Preti Kumari, Troels Bundgaard Sørensen, Sajal K. Das

Computer Science Faculty Research & Creative Works

Long-range Wide-area Network (LoRaWAN) is an innovative and prominent communication protocol in the domain of Low-power Wide-area Networks (LPWAN), known for its ability to provide long-range communication with low energy consumption. However, the practical implementation of the LoRaWAN protocol, operating at the Medium Access Control layer and specially built to work upon the LoRa physical layer, presents numerous research challenges, including network congestion, interference, optimal resource allocation, collisions, scalability, and security. To mitigate these challenges effectively, the adoption of cutting-edge data-driven technologies such as Deep Learning (DL) and Machine Learning (ML) emerges as a promising approach. Interestingly, very few existing …

Cmsi Note #12: Finally, A Pla Navy Missile Gap?, Ian Easton

CMSI Notes

This month a PRC government-owned defense magazine published a special report on one of the U.S. Navy’s newer missiles, calling it a “huge threat” and predicting it will “massively change” the future of naval warfare. The missile? The AIM-174B, an air launched variant of the Navy’s Standard Missile 6 (SM-6). What is it about this weapon that warranted a special report by PRC experts?

CMSI’s Perspectives and Key Takeaways:

• A PRC government-owned defense magazine has called the U.S. Navy’s AIM-174B missile a “huge threat” and game-changer for the future of naval warfare.
• The PRC source says the American missile could …

Oral Inflammation And Microbiome Dysbiosis Exacerbate Chronic Graft-Versus-Host Disease, Yui Kambara, Hideaki Fujiwara, Akira Yamamoto, Kazuyoshi Gotoh, Shuma Tsuji, Mari Kunihiro, Tadashi Oyama, Toshiki Terao, Ayame Sato, Takehiro Tanaka, Daniel Peltier, Keisuke Seike, Hisakazu Nishimori, Noboru Asada, Daisuke Ennishi, Keiko Fujii, Nobuharu Fujii, Ken-Ichi Matsuoka, Yoshihiko Soga, Pavan Reddy, Yoshinobu Maeda

Faculty, Staff and Students Publications

The oral microbiota, second in abundance to the gut, is implicated in chronic systemic diseases, but its specific role in graft-versus-host disease (GVHD) pathogenesis has been unclear. Our study finds that mucositis-induced oral dysbiosis in patients after hematopoietic cell transplantation (HCT) associated with increased chronic GVHD (cGVHD), even in patients receiving posttransplant cyclophosphamide. In murine HCT models, oral dysbiosis caused by bilateral molar ligatures exacerbated cGVHD and increased bacterial load in the oral cavity and gut, with Enterococcaceae significantly increasing in both organs. In this model, the migration of Enterococcaceae to cervical lymph nodes both before and after transplantation activated …

Understanding The Relationship Between Pm2.5 And Aerosol Optical Depth, Haihui Zhu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Ambient fine particulate matter (PM2.5) is the leading global environmental determinant of health, with millions of attributable deaths annually. However, large gaps exist in ground-based PM2.5 monitoring. Satellite remote sensing offers information to fill these gaps worldwide when augmented with information from a chemical transport model. More specifically, this satellite-derived PM2.5 is obtained from satellite retrieved aerosol optical depth (AOD) by applying the modeled PM2.5 to AOD relationship (η). Uncertainties, however, exist in the estimation of PM2.5, particularly from the modeled η. This dissertation focuses on understanding the spatial distribution of η and model developments for improved simulation of it. …

Coastal And Rural Digital Exclusion - The Case For Voice Ai, Rory Baxter, Oksana Hagen, Amir Aly, Ray Jones, Katharine Willis

School of Nursing and Midwifery

The adoption of digital platforms for health and social resources disadvantages vulnerable populations, including older adults and those living in remote or deprived areas. This could be remediated using voice-based conversational AI (Voice AI) systems delivered via landline phone, bypassing the requirement for digital device access or digital skills. British rural and coastal regions often have poorer digital infrastructure and pockets of deprivation, and consequently higher levels of digital exclusion. This study explores digital exclusion in Southwest England and the suitability of Voice AI systems for supporting digital inclusion. Seventeen participants aged 50 years or over were interviewed by telephone …

“Where War Is God And God Is War:” Women’S Religious Great War Poetry And Homefront Lines, Faith Ellington

LSU Doctoral Dissertations

This project seeks to redefine war’s poetic landscape. Through a focus on women’s Great War poetry, I argue against a dichotomous home front | front line poetic barrier and instead explore the intermingling of wartime spaces. Women’s WWI poetry, I argue, exists within a space I call the homefront lines, a space in which women produce writing from their full experiences of war regardless of combatant status. The homefront lines must be included in World War I literary canons in order to fully recognize the humanity of women during wartime and to fully grasp the war’s impact on poetry …

Spectator 2025-02-20, Editors Of The Spectator

The Spectator

No abstract provided.

Kenyon Collegian - February 20, 2025

The Kenyon Collegian

No abstract provided.