Digital Commons Network^™

Every Jump Is A Leap Of Faith-Just Ask Evel Knievel!, Vicente Orozco-Sevilla, Joseph S Coselli

Faculty, Staff and Students Publications

No abstract provided.

Response To: Correspondence On “Hyperleukocytosis In A Neuroblastoma Patient After Treatment With Natural Killer T Cells Expressing A Gd2-Specific Chimeric Antigen Receptor And Il-15” By Ataca Atilla And Atilla, Gengwen Tian, Amy N Courtney, Andras Heczey, Leonid S Metelitsa

Faculty, Staff and Students Publications

No abstract provided.

A Comprehensive Atlas Of Aav Tropism In The Mouse, Christopher J Walkey, Kathy J Snow, Jote Bulcha, Aaron R Cox, Alexa E Martinez, M Cecilia Ljungberg, Denise G Lanza, Marco De Giorgi, Marcel A Chuecos, Michele Alves-Bezerra, Carlos Flores Suarez, Sean M Hartig, Susan G Hilsenbeck, Chih-Wei Hsu, Ethan Saville, Yaned Gaitan, Jeff Duryea, Seth Hannigan, Mary E Dickinson, Oleg Mirochnitchenko, Dan Wang, Cathleen M Lutz, Jason D Heaney, Guangping Gao, Stephen A Murray, William R Lagor

Faculty, Staff and Students Publications

Gene therapy with adeno-associated virus (AAV) vectors requires knowledge of their tropism within the body. Here we analyze the tropism of 10 naturally occurring AAV serotypes (AAV3B, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAVrh8, AAVrh10, and AAVrh74) following systemic delivery into male and female mice. A transgene-expressing ZsGreen and Cre recombinase was used to identify transduction in a cell-dependent manner based on fluorescence. Cre-driven activation of tdTomato fluorescence offered superior sensitivity for transduced cells. All serotypes except AAV3B and AAV4 had high liver tropism. Fluorescence activation revealed transduction of unexpected tissues, including adrenals, testes, and ovaries. Rare transduced cells within …

Factors Driving Adolescent Tuberculosis Incidence By Age And Sex In 30 High-Tuberculosis Burden Countries: A Mathematical Modelling Study, Silvia S Chiang, Megan B Murray, Alexander W Kay, Peter J Dodd

Faculty, Staff and Students Publications

INTRODUCTION: During adolescence, tuberculosis incidence rises, with a greater increase in males compared with females. Tuberculosis notifications and estimates infrequently disaggregate adolescent age groups. Moreover, the factors that drive the increases in overall incidence and the male-to-female (MF) ratio remain unclear.

METHODS: We constructed a mechanistic model to estimate cumulative Mycobacterium tuberculosis infection and tuberculosis disease incidence in the WHO’s 30 high-tuberculosis burden countries (HBCs), which represent 86%–90% of global tuberculosis incidence. We derived infection risk from tuberculosis prevalence and assortative social mixing based on sex and age (10–14 years vs 15–19 years old). We adjusted age subgroup-specific risks of …

Jamie Dimon Talks About Regulation, Remote Work, And What Keeps Him Up At Night, Michael Mcdowell

Documents

No abstract provided.

Does Interdisciplinary Group Care For The Treatment Of Endometriosis Improve Pain Interference: Protocol For A Pilot Randomised Controlled Trial At An Urban Academic Medical Centre, Whitney Trotter Ross, Sarah Buday, Emily Yakel, Dineo Khabele, Joyce Balls-Berry, Sawsan As-Sanie, Graham Colditz, Ana A Baumann

2020-Current year OA Pubs

INTRODUCTION: Endometriosis affects 10-15% of people assigned female at birth and can cause chronic pelvic pain and impair many domains of quality of life, such as fertility, mood and bladder, bowel and sexual function. Current treatments often fail, leading to recurrent pain and the need for reintervention. As endometriosis negatively affects many domains of life, a variety of non-pharmacological treatments modestly improve symptoms. To bundle these interventions into accessible packaging, our interdisciplinary team developed a novel endometriosis intervention titled 'Peer-Empowered Endometriosis Pain Support (PEEPS)', an 8-week integrative group care intervention. Here, we present the protocol for a pilot randomised controlled …

Clinical Specialists’ Perceptions Of Their Ability To Diagnose Autism In Toddlers, Donna Morgan Johnson

Walden Dissertations and Doctoral Studies

Autism is diagnosable by a clinical specialist, and toddlers who receive an early diagnosis by a clinical specialist are more likely to receive the appropriate early intervention services and supports that meet their needs. However, researchers have found that clinical specialists have doubts regarding the accuracy of their diagnoses in toddlers. The purpose of this generic qualitative study was to provide an understanding of clinical specialists’ perceptions of their abilities to make an early diagnosis of autism in toddlers. Self-efficacy theory served as the theoretical framework. Semi-structured interview data were collected from 12 clinical psychologists with experience diagnosing autism in …

Reforming H-2a: Protecting Migrant Workers Before Arrival On U.S. Farms, Isabella J. Cheng

Duke Law Journal

Migrant farmworkers who seasonally enter the United States to work on farms using H-2A visas suffer well-documented abuses. Dependent on their employers for legal status, housing, transportation, and food, H-2A workers succumb to a power dynamic that keeps workers from speaking out for fear of being fired and possibly deported. However, little academic attention has been paid to the problematic dynamics that trap these workers in a cycle of abuse long before they even set foot on U.S. farms, starting with the H-2A recruitment process. This process, which often starts in Mexico, involves an opaque and complicated network of recruiters …

Nucleoredoxin Regulates Wnt Signaling During Pituitary Stem Cell Differentiation, Michelle L. Brinkmeier, Leonard Y M Cheung, Sean P. O'Connell, Diana K. Gutierrez, Eve C. Rhoads, Sally A. Camper, Shannon W. Davis

Faculty Publications

Nucleoredoxin (Nxn) encodes a multi-functional enzyme with oxidoreductase activity that regulates many different signaling pathways and cellular processes in a redox-dependent manner. Rare NXN mutations are reported in individuals with recessive Robinow syndrome, which involves mesomelic skeletal dysplasia, short stature, craniofacial dysmorphisms, and incompletely penetrant heart and palate defects. Here we report that Nxn is expressed in the ventral diencephalon and developing pituitary gland, and that Nxn deficient mice have pituitary dysmorphology and craniofacial abnormalities that include defects in the skull base and cleft palate. Nxn mutant mice exhibit reduced WNT signaling and reduced differentiation of pituitary stem …

Pre-Exposure Prophylaxis Uptake Among Black/African American Men Who Have Sex With Other Men In Midwestern, United States: A Systematic Review, Oluwafemi Adeagbo, Oluwaseun Abdulganiyu Badru, Prince Addo, Amber Hawkins, Monique J. Brown Ph.D., Mph, Xiaoming Li, Rima Afifi

Faculty Publications

Introduction: Black/African American men who have sex with other men (BMSM) are disproportionately affected by HIV, experience significant disparities in HIV incidence, and face significant barriers to accessing HIV treatment and care services, including pre-exposure prophylaxis (PrEP). Despite evidence of individual and structural barriers to PrEP use in the Midwest, no review has synthesized this finding to have a holistic view of PrEP uptake and barriers. This review examines patterns of, barriers to, and facilitators of PrEP uptake among BMSM in the Midwest, United States (US).

Methods: Five databases (CINAHL Plus, PUBMED, PsycINFO, SCOPUS, and Web of Science) were searched …

The Parthenon, March 05, 2025, Sarah Davis, Baylee Parsons, Kaitlyn Fleming, Nate Harrah, Caden Adkins, Scott Price, Ella Bumgardner, Wade Sullivan

The Parthenon

No abstract provided.

Byu Nano-Carbon Physics Lab, Robert Davis Dr., Richard Vanfleet Dr., Felipe Rivera Dr., David Hayes, Nick Allen, Bridget Kemper, Dan Broadbent

Faculty Publications

BYU Nano-Carbon Physics Lab

Started in 2003 by Physics Professors Robert Davis and Richard Vanfleet, who received the BYU Technology Transfer Award in 2024.

Over 81 undergraduate and 21 graduate student projects in the lab have advanced carbon nanotube (CNT) research.

Applications of research from the lab have resulted in over 30 patents, many of which have been licensed to companies for use in the world.

This display showcases highlights of work done in the lab.

Diagnostic Stewardship And The Mitigation Of Treatment Of Asymptomatic Bacteriuria, Raimonda Kathryn Clarke

Walden Dissertations and Doctoral Studies

Urinalyses and urine cultures are being ordered at the facility of concern without regard to patient history/symptomatology, leading to inappropriate treatment of asymptomatic bacteriuria (ASB) and unnecessary antibiotic prescriptions. The following practice-focused question was developed to address this practice concern: Can an educational program focused on diagnostic stewardship and the mitigation of treatment of asymptomatic bacteriuria improve clinician awareness, knowledge, and confidence in identifying and diagnosing asymptomatic bacteriuria in patients over age 65 in the outpatient setting? Thus, the purpose of this doctor of nursing practice (DNP) project was to close the identified knowledge and attitude gap in a moderate-size …

Human Brain Tissue With Moghe Carrying Somatic Slc35a2 Variants Reveal Aberrant Protein Expression And Protein Loss In The White Matter, Erica Cecchini, Simon Geffers, Roland Coras, Dorothea Schultheis, Christian Holtzhausen, Kristina Karandasheva, Harald Herrmann, Friedrich Paulsen, Christine Stadelmann, Katja Kobow, Till Hartlieb, Christian G Bien, Dennis Lal, Ingmar Blumcke, Lucas Hoffmann

Faculty, Staff and Student Publications

Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) is a recently described disease entity primarily affecting young children with drug-resistant epilepsy, mainly affecting the frontal lobe. The condition is histopathologically defined by focal lesions with patchy areas of increased oligodendroglial cell density at the grey-white matter boundary and heterotopic neurons in the white matter. Approximately half of the individuals with MOGHE carry brain somatic variants in the SLC35A2 gene, which affects the UDP-galactose transporter and thus sphingolipid glycosylation. To investigate the impact of SLC35A2 variants on protein expression, we analysed MOGHE brain tissue with and without SLC35A2 …

Ksu Symphony Orchestra

Bailey School of Music Concert Programs

Nathaniel F. Parker, Music Director and Conductor

featuring

Gabriel Harmon, Cello

Jacob Harrison, Guest Conductor

Digital Multimodal Composing In An L2 Italian Classroom: The Effects Of Digital Video Projects On Students’ Development And Investment, Francesca Marino

USF Tampa Graduate Theses and Dissertations

Despite the calls for integrating digital multimodal composing (DMC) into second language (L2) pedagogy, learners’ gains in terms of L2 development beyond writing remain largely unexplored. Additionally, while research points to the potential of DMC to promote students’ engagement and motivation in the L2 classroom (e.g., Hava, 2021; Hull & Nelson, 2005; Shin & Cimasko, 2008), learners’ investment (Darvin & Norton, 2015, 2023; Norton, 1995) in L2 learning through DMC has been underrepresented in previous literature. In addition, DMC research on investment until now has almost exclusively focused on the learning of English as a foreign or second language (e.g., …

Experiment-Based Superposition Thermal Modeling Of Laser Powder Bed Fusion, Cody S. Lough, Tao Liu, Robert G. Landers, Douglas A. Bristow, James A. Drallmeier, Ben Brown, Edward C. Kinzel

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Parts experience significant local thermal variations during the Laser Powder Bed Fusion (LPBF) metal Additive Manufacturing (AM) process, providing a potential source of defects. Near real-time thermal predictions can enable better process planning and facilitate corrections on subsequent layers to enable the engineering of laser parameter and scan path combinations that avoid defect inducing scenarios. This paper considers an experiment-based Discrete Green's Function (DGF) thermal model for temperature field prediction in LPBF. An analytical framework is developed and used to calculate an experimental DGF (i.e., powder bed's single pulse temperature response) from spatiotemporal Short-Wave Infrared (SWIR) camera data. The extracted …

Towards A Realistic View Of Consumer Behaviour, Rod Sheaff

Peninsula Medical School

Marginal utility (MU) theories of consumer demand assume that consumers try to maximise a generic benefit (‘utility’) by selecting purchases giving equal marginal utility per unit of cost, from which are predicted the observed relationships between price changes and quantities of demanded consumer goods. Attempts to remedy the explanatory shortcomings of MU theory usually supplement it with additional assumptions. This paper proposes taking that approach to its logical conclusion by using consumer and psychological research findings not to supplement but to replace the concept of utility entirely with realistic explanations of consumer behaviour.

Social Media As A Platform For Cancer Care Decision-Making Among Women: Internet Survey-Based Study On Trust, Engagement, And Preferences, Anna Rose Johnson, Grace Anne Longfellow, Clara N Lee, Benjamin Ormseth, Gary B Skolnick, Mary C Politi, Yonaira M Rivera, Terence Myckatyn

2020-Current year OA Pubs

BACKGROUND: Decision aids improve patient and clinician decision-making but are underused and often restricted to clinical settings.

OBJECTIVE: Given limited studies analyzing the feasibility of disseminating decision aids through social media, this study aimed to evaluate the acceptability, trust, and engagement of women with social media as a tool to deliver online decision aids for cancer treatment.

METHODS: To prepare for potential dissemination of a breast cancer decision aid via social media, a cross-sectional survey in February 2023 was conducted via Prime Panels, an online market research platform, of women aged 35-75 years in the United States. Demographics, health, cancer …

Systematic Method For Developing Tailored Strategies For Implementing Point-Of-Care Procalcitonin Testing To Guide Antibiotic Prescribing In Swiss Primary Care: A Protocol For A Mixed-Methods Participatory Approach, Aline Wolfensberger, Sophie Cl Gendolla, Jelena Dunaiceva, Catherine Plüss-Suard, Anne Niquille, Anna Nicolet, Joachim Marti, Byron J Powell, Rahel Naef, Noémie Boillat-Blanco, Yolanda Mueller, Lauren Clack

2020-Current year OA Pubs

INTRODUCTION: Antimicrobial resistance is a major global health threat, driven largely by the misuse and overuse of antibiotics. Point-of-care (POC) tests for inflammatory biomarkers like procalcitonin (PCT) have shown promise in reducing unnecessary antibiotic prescriptions. The hybrid type II ImpPro trial aims to evaluate the implementation and effectiveness of POC-PCT on antibiotic prescriptions by primary care physicians (PCP) in French-speaking Switzerland. Implementation is planned to include a multifaceted strategy delivered mainly, but not exclusively, via PCP quality circles. Currently, little guidance exists on how to best tailor the implementation strategies to a specific context. This study protocol describes the comprehensive …

Biophysical Insights Into Immunoglobulin Interactions With Influenza Viral Proteins, Yuanyuan He

McKelvey School of Engineering Graduate Student Theses & Dissertations

Influenza viruses cause a significant burden across the globe leading to thousands of mortalities annually. It remains challenging to acquire long-lasting immunity against influenza viruses due to the rapid rate of mutation within circulating strains and limited protection provided by seasonal flu vaccines. While the generation of influenza-specific antibodies provides a major source of protection against viral infection, our understanding of how biophysical properties of antibody-antigen interaction influence antibody protection against influenza viruses remains elusive. To address these challenges, we first developed imaging-based approaches in combination with computational models to elucidate the extent and mechanism of antibody inhibition of influenza …

Biophysical Insights Into Immunoglobulin Interactions With Influenza Viral Proteins, Yuanyuan He

McKelvey School of Engineering Graduate Student Theses & Dissertations

Influenza viruses cause a significant burden across the globe leading to thousands of mortalities annually. It remains challenging to acquire long-lasting immunity against influenza viruses due to the rapid rate of mutation within circulating strains and limited protection provided by seasonal flu vaccines. While the generation of influenza-specific antibodies provides a major source of protection against viral infection, our understanding of how biophysical properties of antibody-antigen interaction influence antibody protection against influenza viruses remains elusive. To address these challenges, we first developed imaging-based approaches in combination with computational models to elucidate the extent and mechanism of antibody inhibition of influenza …

Uncertainty Propagation And Sensitivity Analysis For Constrained Optimization Of Nuclear Waste Vitrification, Lagrande Gunnell, Xiaonan Lu, John D. Vienna, Dong-Sang Kim, Brian J. Riley, John Hedengren

Faculty Publications

The vitrification of high-level waste (HLW) by heating a mixture of glass-forming chemicals (GFCs) with the waste can be improved using a constrained optimization problem. This study explores how different uncertainty propagation (UP) methods implemented with the optimization process can affect the glass formulation of nuclear waste glasses. UP is the effort of propagating uncertain inputs through a system to understand and quantify output distributions. Uncertainty intervals are crafted from output distributions to inform the optimization algorithm. UP is often implemented with Monte Carlo (MC) sampling for large nonlinear systems, which can be difficult to implement within a constrained optimization …

War And Media, William. E. Biernatzki S.J.

Communication Research Trends

No abstract provided.

Teaching And Learning In The New Millennium: Transformative Technologies In A Transformable World, Ralph Olliges, Sebastian Mahfood

Communication Research Trends

No abstract provided.

Understanding Expectations: International Graduate Students’ Perspectives Of An Internationalized Curriculum In Canadian Universities, Siyin Liang

Critical Internationalization Studies Review

No abstract provided.

Intra-Africa Student Mobility From A Critical Perspective, Tibelius Amutuhaire

Critical Internationalization Studies Review

No abstract provided.

“Time Is Our Only Ally!”: Indigenous Heroism And Native Slipstream In Turok, Son Of Stone, Justin Wigard

Heroism Science

In this article, I draw on Frederick Luis Aldama’s framework of Graphic Indigeneity to revisit the long history of an Indigenous hero figure in comics: Turok, a pre-Columbian Mandan warrior lost in a prehistoric space known as the Lost Valley. First appearing in Dell’s Four Color Comics #596 (1954), Turok has appeared throughout comics history for nearly 70 years, primarily written and drawn by white creative teams, yet a visually, narratively prominent Indigenous hero in the comics page, one who has periodically been a top-selling popular character in the comics industry. To this end, I argue that Turok is a …

Walter J. Ong, S.J.: A Retrospective, Paul A. Soukup S.J.

Communication Research Trends

No abstract provided.

Sports And Media, Daniel Beck, Louis Bosshart

Communication Research Trends

No abstract provided.