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Articles 56311 - 56340 of 1443904
Full-Text Articles in Entire DC Network
Improving The Mq For Pastoral Counseling At Hesed Counseling Ministries To Benefit Pro-Life Victims Of Pro-Abortionist Violence, Sean Michael Patrick Ferreiro
Improving The Mq For Pastoral Counseling At Hesed Counseling Ministries To Benefit Pro-Life Victims Of Pro-Abortionist Violence, Sean Michael Patrick Ferreiro
Doctoral Dissertations and Projects
Biblical Christianity has ubiquitously denounced abortion. Unfortunately, an unprecedented number of physical attacks on the pro-ministry’s volunteers and properties have resulted in traumatic experiences. Counseling services are the natural recommendation for these volunteers thereafter. However, secular counselors are often incongruent with the values of the pro-life ministry. Hesed Counseling Ministries offers counseling services for pro-life volunteers. As a group of solution-focused practitioners, they utilize the miracle-question (MQ). To create a counseling milieu congruent to the unique subculture of the pro-life ministry, they created their own MQ. It was bereft of the voices and verbiage of the pro-life ministry. Therefore, the …
The Impact Of A Social Media Literacy Program On Adolescent Subjective Well-Being, Miranda L. Virone
The Impact Of A Social Media Literacy Program On Adolescent Subjective Well-Being, Miranda L. Virone
Doctoral Dissertations and Projects
This study examined the impact of a Social Media Literacy (SML) program on adolescent subjective well-being. The research was conducted in a public middle school in rural western Pennsylvania, with 102 eighth-grade students participating in a six-week SML intervention as part of regular educational practices. The study utilized pre- and post-intervention assessments to measure changes in both SML and subjective well-being. Data analysis included paired samples t-tests to assess within-group effects and Pearson’s r correlation to evaluate associations between variables. Results indicated no statistically significant effect of the SML program on subjective well-being, leading to the rejection of the first …
The Impact Of Religious Music On Psychological Well-Being: A Survey Study Of Chinese Christians In Hong Kong Churches, Ka Man Lee
Doctoral Dissertations and Projects
This cross-sectional survey investigates the relationship between listening to religious music and psychological well-being among Chinese Christians in Hong Kong, addressing a critical gap in Asian studies. Data were collected from 243 participants through a survey comprising demographic questions, music-listening habits (weekly frequency, average duration, and music era preference), and the 24-item Chinese Ryff Psychological Well-being Scale. Multiple linear regression and ANOVA analyses reveal that the average duration of listening to religious music positively associates with overall psychological well-being and its six dimensions, while frequency shows a negative relationship. Traditional religious music (composed in or before 1980) is associated with …
The Moderating Effect Of Emotional Intelligence On Teacher Self-Efficacy And Burnout, Ronda L. Kutcherman
The Moderating Effect Of Emotional Intelligence On Teacher Self-Efficacy And Burnout, Ronda L. Kutcherman
Doctoral Dissertations and Projects
The number of teachers who are leaving the profession is exponentially increasing. Teachers are emotionally exhausted. In addition to the professional description and the job demands of teaching are the psychological stresses and emotional strains experienced by many teachers. These stresses and strains are linked to the professional workload that teachers manage daily. Excessive paperwork, attendance at meetings, participation in professional development after school hours, carrying work home, and the expectation to provide instruction for diverse student ability levels or academic needs are part of the workload. This study aimed to measure the moderating effect that emotional intelligence (EI) has …
Interpreting The Re-Engagement Of Disenfranchised Youth With Disabilities Through The Lived Experiences Of Alternative High School Staff Members: A Hermeneutic Phenomenological Study, Stephanie Jean Smith
Interpreting The Re-Engagement Of Disenfranchised Youth With Disabilities Through The Lived Experiences Of Alternative High School Staff Members: A Hermeneutic Phenomenological Study, Stephanie Jean Smith
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenological study was to interpret the lived experiences of re-engaging at-risk students with disabilities after disenfranchisement from traditional educational settings for non-compulsory alternative charter school staff members at Southwest Charter Academy in the Southwest United States. The theory guiding this study was Bronfenbrenner’s theory on bioecological systems, as it connects the influences of interactions to an individual’s development of behaviors. The central research question for this qualitative study asked: What are the lived experiences of non-compulsory alternative charter school staff members in the Southwest United States who work to re-engage at-risk students with disabilities after …
The Resurrection According To Luke: The Meaning And Significance Of Pneumatology In Luke’S Resurrection Theology, Ryan R. Jacobs
The Resurrection According To Luke: The Meaning And Significance Of Pneumatology In Luke’S Resurrection Theology, Ryan R. Jacobs
Doctoral Dissertations and Projects
The aim of this study, then, is to demonstrate the meaning and significance of Pneumatology in Luke’s resurrection theology based on the following: a) Luke’s “it is written” qualifier of the third-day resurrection, and his description of the Spirit’s activity upon the virgin Mary in his birth narrative, connect Luke with the Spirit’s activity in the creation narrative and nascent resurrection themes in Scripture; b) Luke’s use of the three-fold identity for the son of God (Jesus, Christ, and Lord) and the centrality of Peter’s Pentecost sermon for Luke wherein the resurrection confirmed this identity and enabled Jesus to pour …
Lived Experiences Of High School Teachers' Professional Development Post-Covid-19 Pandemic In Rural Georgia: A Transcendental Phenomenology Study, Jesse Regalado
Doctoral Dissertations and Projects
The purpose of this phenomenological study is to describe the lived experiences of high school teachers' professional development post-COVID-19 pandemic in rural Georgia, U.S.A. The theories guiding the research are Piaget's theory of disequilibration, addressing how one accommodates and assimilates to adapt to change, and Festinger's (1957) theory of cognitive dissonance, explaining how one adapts, assimilates, and accommodates to avoid disharmony. The study's central question is, what are high school teachers' perceptions on the practical or academic professional development they received post-COVID-19 pandemic in rural Georgia, United States, used to promote leadership, teaching mastery, or pedagogical practices? This study utilized …
The Lived Experiences Of Mothers Leaving The Fundamentalist Church Of Jesus Christ Of Latter-Day Saints: A Phenomenological Approach, Natasha Tebbs
The Lived Experiences Of Mothers Leaving The Fundamentalist Church Of Jesus Christ Of Latter-Day Saints: A Phenomenological Approach, Natasha Tebbs
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological qualitative study was to provide a holistic understanding of the lived experiences of mothers who leave the Fundamentalist Church of Jesus Christ of Latter-Day Saints (FLDS). This study answered questions related to familial relationships, career and financial experiences, and overall mental health and well-being associated with leaving the FLDS Church. The theory guiding this study was Maslow’s hierarchy of needs, as it related to understanding the complexities of leaving a high-demand religious group. There was a lack of academic literature available on this population, specifically FLDS mothers’ experiences leaving the cultural and religious group. …
You Belong With Me: Examining The Relationship Between Engagement In The “Swifty” Fan Community, Feelings Of Belonging, And Social Identity, Jessica Leigh Webb
You Belong With Me: Examining The Relationship Between Engagement In The “Swifty” Fan Community, Feelings Of Belonging, And Social Identity, Jessica Leigh Webb
Doctoral Dissertations and Projects
Belongingness and social identity shape human behavior and group dynamics, yet their relationship with fan engagement remains understudied. This study examines engagement in the “Swifty” fan community—fans of Taylor Swift—and its relationship with belonging and social identity. A quantitative, correlational design addressed three research questions: (1) the relationship between fan engagement and belonging, (2) the relationship between fan identification and belonging, and (3) the relationship between fan identification and social identity. Data were collected via an online Qualtrics survey incorporating the General Belongingness Scale, Three-Factor Model of Social Identity Scale, Popular Media Fan Identity Scale, and demographic items. The survey …
A New Fossil Woody Flora Of The Late Oligocene-Early Miocene Of Northwest İstanbul With A New Species, Ünal Akkemi̇k, Burcu Üner
A New Fossil Woody Flora Of The Late Oligocene-Early Miocene Of Northwest İstanbul With A New Species, Ünal Akkemi̇k, Burcu Üner
Turkish Journal of Earth Sciences
The silicified wood samples identified in Kabakça (Çatalca) and its surroundings have been found in the west of İstanbul Province. They come from terrestrial clastic sediments of the Late Oligocene-Early Miocene İstanbul Formation. Six silicified wood samples were collected and sectioned in transverse, tangential, and radial planes. As a result, five angiosperm taxa were identified. Three out of six fossil wood samples belong to Lauraceae (Cryptocaryoxylon istanbulensis Akkemik and Üner sp. nov., Lau-rinoxylon ehrendorferi Berger, 1953), and the others to Fabaceae (Dichrostachyoxylon zirkelii (Felix) Müller-Stoll and Mädel 1967), Ulmaceae (Zelkovoxylon crystalliferum Akkemik 2021), and Fagaceae (Quercoxylon mixtum Petrescu 1978). This …
The Moderating Role Of Loneliness In The Relation Between Perceived Pressure To Be Thin, Perfectionism, And Internalizing Problems Among Latina Girls, Melissa Lopez
College of Science and Health Theses and Dissertations
Latina girls are at a high risk of depressive symptoms and self-injurious thoughts and behaviors. This study builds on the Perfectionism Social Disconnection Model to identify factors that may influence the development of these internalizing problems (Hewitt et al., 2006). Perceived pressure to be thin, perfectionistic self-presentation, and loneliness have all been linked to internalizing problems, including depressive symptoms in youth. This study focuses on Latina girls, specifically, and the ways that these variables combine to affect their well-being. This study highlights the relation between pressure to be thin and both depressive symptoms and self-injurious thoughts and behaviors and explores …
Ohio's Unconstitutional Burden Of Proof For Criminal New Trial Motions Based On Newly Discovered Evidence, David B. Alden, Michael P. Koslen
Ohio's Unconstitutional Burden Of Proof For Criminal New Trial Motions Based On Newly Discovered Evidence, David B. Alden, Michael P. Koslen
University of Cincinnati Law Review
No abstract provided.
Evaluation Of The Distress Thermometer In Older Patients With Cancer, Charlotte Zuber, Kristine Swartz, Andrew Chapman, Lora Rhodes, Tingting Zhan, Kuang-Yi Wen
Evaluation Of The Distress Thermometer In Older Patients With Cancer, Charlotte Zuber, Kristine Swartz, Andrew Chapman, Lora Rhodes, Tingting Zhan, Kuang-Yi Wen
Kimmel Cancer Center Faculty Papers
INTRODUCTION: The Geriatric Depression Scale is a useful tool in screening for depression in older adults, a particularly vulnerable population in oncology. The National Comprehensive Cancer Network (NCCN) Distress Thermometer (DT) has been validated as a fast and effective screening tool for psychological distress in general oncology populations, and it could possibly be used as a surrogate for the longer Geriatric Depression Scale (GDS) test in older adults with cancer.
MATERIALS AND METHODS: In this retrospective cross-sectional study in older adults prior to starting cancer treatment, we evaluated the relationship between the DT and GDS by comparing 242 older adults …
Gene Expression Profiling Of Pancreatic Ductal Adenocarcinoma Cells In Hypercapnia Identifies Siah3 As A Novel Prognostic Biomarker, Nitzan Zohar, Ryan Maguire, Saed Khalilieh, Aditi Jain, Dmitriy Bosykh, Wilbur B. Bowne, Harish Lavu, Charles J. Yeo, Avinoam Nevler
Gene Expression Profiling Of Pancreatic Ductal Adenocarcinoma Cells In Hypercapnia Identifies Siah3 As A Novel Prognostic Biomarker, Nitzan Zohar, Ryan Maguire, Saed Khalilieh, Aditi Jain, Dmitriy Bosykh, Wilbur B. Bowne, Harish Lavu, Charles J. Yeo, Avinoam Nevler
Department of Surgery Faculty Papers
Hypercapnia is a key feature of the respiratory microenvironment in many pathologic conditions. It occurs both as a regional and as a systemic process, and it is associated with multiple metabolic changes such as mitochondrial dysfunction, decreased ATP production, and metabolic shift from glycolytic energy production to fatty acid metabolism. In the cancer tumor microenvironment, hypercapnia has been linked at times to enhanced cell migration, invasion, and chemoresistance. Our previous work has shown that hypercapnia-associated gene signatures can be used as prognostic biomarkers. However, unlike the hypoxia-inducible factor pathway, there are no validated targets to quantify hypercapnia. In this study, …
Dependence Of Mitochondrial Calcium Signalling And Dynamics On The Disaggregase, Clpb, Donato D'Angelo, Víctor H. Sánchez-Vázquez, Benjamín Cartes-Saavedra, Denis Vecellio Reane, Ryan R. Cupo, Hilda Delgado De La Herran, Giorgia Ghirardo, James Shorter, Ron A. Wevers, Saskia B. Wortmann, Fabiana Perocchi, Rosario Rizzuto, Anna Raffaello, György Hajnóczky
Dependence Of Mitochondrial Calcium Signalling And Dynamics On The Disaggregase, Clpb, Donato D'Angelo, Víctor H. Sánchez-Vázquez, Benjamín Cartes-Saavedra, Denis Vecellio Reane, Ryan R. Cupo, Hilda Delgado De La Herran, Giorgia Ghirardo, James Shorter, Ron A. Wevers, Saskia B. Wortmann, Fabiana Perocchi, Rosario Rizzuto, Anna Raffaello, György Hajnóczky
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Cells utilize protein disaggregases to avoid abnormal protein aggregation that causes many diseases. Among these, caseinolytic peptidase B protein homolog (CLPB) is localized in the mitochondrial intermembrane space and linked to human disease. Upon CLPB loss, MICU1 and MICU2, regulators of the mitochondrial calcium uniporter complex (mtCU), and OPA1, a main mediator of mitochondrial fusion, become insoluble but the functional outcome remains unclear. In this work we demonstrate that CLPB is required to maintain mitochondrial calcium signalling and fusion dynamics. CLPB loss results in altered mtCU composition, interfering with mitochondrial calcium uptake independently of cytosolic calcium and mitochondrial membrane potential. …
Quiet Quitting Out Loud: A Qualitative Study Of Digital Communication Through Public Discourse On Youtube Regarding An Evolving Work Behavior Trend, Jessica R. Koch
Quiet Quitting Out Loud: A Qualitative Study Of Digital Communication Through Public Discourse On Youtube Regarding An Evolving Work Behavior Trend, Jessica R. Koch
Doctoral Dissertations and Projects
This dissertation examines the phenomenon of online discourse surrounding quiet quitting, a trending movement that has gone viral on social media. This trend encourages individuals to set work-life boundaries and reject excessive labor demands by contributing only what is required at work. The study aims to explore how news sources and users alike engage with this concept, particularly using YouTube as a platform for advocacy and community-building. A qualitative content analysis was conducted to analyze a sample of news segment videos published on YouTube on the topic of quiet quitting, focusing on emerging themes within those conversations and the role …
Racism And The African American Church: The Impact That Racial Discrimination Has On The Theology Of African American Churches, Naeem J. Bourne
Racism And The African American Church: The Impact That Racial Discrimination Has On The Theology Of African American Churches, Naeem J. Bourne
Doctoral Dissertations and Projects
The theology of the earlier evangelicals (white theology) has influenced the African American church. More to the point, the theology of the white evangelicals (The Puritans) has had both positive and negative impacts on the African American church, which birthed black theology in the United States. The influence continues today in more subtle ways (e.g., an image of a European blue-eyed man imposter posing as Jesus) and not-so-subtle forms (e.g., Kenneth Copeland’s video of making light of slavery in America). The “Protestant icon” of the blue-eyed Jesus was born in the 1940s and has entered African American homes nationwide. The …
Evaluating The Impact Of The Scottish Enlightenment On The Formation Of The United States Government, Lene Carroll
Evaluating The Impact Of The Scottish Enlightenment On The Formation Of The United States Government, Lene Carroll
Doctoral Dissertations and Projects
To what extent did the Scottish Enlightenment impact the founding of the United States government? This dissertation begins to answer the question by first acknowledging that the Scottish Enlightenment as an independent branch of the overarching intellectual movement separate from both the British and the French. Scottish Enlightenment theories were not only relegated to the capital, but instead, would spread throughout the cities and towns to encourage a community involvement in the growth of new ideas. Some key theories attributed to the Scottish Enlightenment are the Stadial Theory, Ideal Theory, Common-Sense Philosophy, and most well-known, Moral Philosophy. Tracing the ideological …
Deaf Culture Matters: The Perceived Implementation Of Culturally Responsive Teaching Practices In Public Deaf Education, Stephanie Elpenord-Senatus
Deaf Culture Matters: The Perceived Implementation Of Culturally Responsive Teaching Practices In Public Deaf Education, Stephanie Elpenord-Senatus
Graduate Theses & Dissertations
Over the last five decades, the number of Deaf and hard-of-hearing (DHH) students enrolled in public schools has significantly increased, while fewer attend traditional residential schools for the Deaf. Although public schools may provide academic advantages, concerns remain about their capacity to meet the cultural, linguistic, and social-emotional needs of DHH students. Access to Deaf culture is essential for students to develop a healthy Deaf identity, feel a sense of belonging, and participate meaningfully in their education.
While the Culturally Responsive Teaching (CRT) framework has been widely researched, there is limited work examining Deaf culture explicitly through the lens of …
Racial Differences In Knowledge, Attitudes Toward Vaccination, And Risk Practices Around Lyme Disease In The United States, Madiha Shafquat, Niyati Patel, Brandon Mcfadden, James H. Stark, L. Hannah Gould
Racial Differences In Knowledge, Attitudes Toward Vaccination, And Risk Practices Around Lyme Disease In The United States, Madiha Shafquat, Niyati Patel, Brandon Mcfadden, James H. Stark, L. Hannah Gould
Agricultural Economics and Agribusiness Faculty Publications and Presentations
Introduction Lyme disease (LD) incidence in the United States is highly regional, with most cases occurring in 16 high-incidence jurisdictions. LD incidence and severity of disease have been found to vary by race. This study describes racial differences in knowledge, attitudes toward vaccination, and risk practices related to LD.Methods Four web-based surveys were conducted with adults and caregivers of children in high-incidence jurisdictions and 10 states neighboring them. Respondents were recruited via an established online panel to represent the general population. Self-reported race was pooled into 3 categories: 'White', 'Black or African American', and 'Other' for analysis. Analyses were conducted …
From Farm To Friend: Fostering Compassion Toward Farmed Animals Through Design, Natalie Kosmos
From Farm To Friend: Fostering Compassion Toward Farmed Animals Through Design, Natalie Kosmos
University Honors Theses
This thesis explores how human compassion for farmed animals can be fostered through design. By analyzing the existing language, imagery, and social norms surrounding animal commodification, the research highlights the root of the issue: how humans perceive farmed animals in relation to themselves. Understanding how humans view and think about farmed animals is important for creating a message that disrupts these existing norms. The culmination of this thesis is a campaign, "From Farm to Friend" which is designed to be approachable and informative, encouraging the audience to have compassion for farmed animals and change their perception, from farm--to friend.
Digital Stratification: Comparing Digital Literacy Practices Among Aboriginal And Mainstream Children In Australian Homes, Huan Gao, Gui Ying Annie Yang-Heim
Digital Stratification: Comparing Digital Literacy Practices Among Aboriginal And Mainstream Children In Australian Homes, Huan Gao, Gui Ying Annie Yang-Heim
Faculty Publications - College of Education
This qualitative study examines the home digital literacy practices of Aboriginal and Mainstream elementary-age children in Australia, highlighting how socio-economic and cultural factors influence these practices. This study integrates conceptural framework such as capital, digital capital, and social reproduction theory to analyze conversational interviews conducted with six children. Our findings reveal significant disparities in digital capital accumulation, primarily driven by socio-economic differences and varied access to digital resources. Mainstream students typically possess more digital capital, which allows them to navigate the digital landscape more effectively and perpetuate systemic inequalities. The enduring digital divide reinforces existing economic and social hierarchies, exacerbating …
Resiliency In Child-Caregiver Dyads And The Impact On Health Outcomes In Sickle Cell Disease, Jessica A Zavadil, Melissa Azul, Brian D Carpenter, Cecelia Calhoun
Resiliency In Child-Caregiver Dyads And The Impact On Health Outcomes In Sickle Cell Disease, Jessica A Zavadil, Melissa Azul, Brian D Carpenter, Cecelia Calhoun
2020-Current year OA Pubs
No abstract provided.
Racial And Ethnic Inequalities In Actual Vs Nearest Delivery Hospitals, Nansi S. Boghossian, Lucy T. Greenberg, Jeffrey S. Buzas, Joshua Radack, Molly Passarella, Jeannette Rogowski, George R. Saade, Ciaran S. Phibbs, Scott A. Lorch
Racial And Ethnic Inequalities In Actual Vs Nearest Delivery Hospitals, Nansi S. Boghossian, Lucy T. Greenberg, Jeffrey S. Buzas, Joshua Radack, Molly Passarella, Jeannette Rogowski, George R. Saade, Ciaran S. Phibbs, Scott A. Lorch
Faculty Publications
IMPORTANCE Minoritized racial and ethnic groups, such as American Indian and Black individuals, often receive lower quality health care compared with White individuals. There is limited understanding of how these disparities extend to obstetric care, particularly when comparing the quality of care at the actual delivery hospital vs the nearest obstetric hospital based on the birthing individual’s residence. OBJECTIVE To examine inequality in care based on the actual delivery hospital and the closest delivery hospital to the birthing individual’s residential zip code centroid. DESIGN, SETTING, AND PARTICIPANTS This population-based retrospective cohort study used data from 5 states (2008 to 2020 …
Rare Damaging Ccr2 Variants Are Associated With Lower Lifetime Cardiovascular Risk, Marios K Georgakis, Rainer Malik, Omar El Bounkari, Natalie R Hasbani, Jiang Li, Jennifer E Huffman, Gabrielle Shakt, Reinier W P Tack, Tamara N Kimball, Yaw Asare, Alanna C Morrison, Noah L Tsao, Renae Judy, Braxton D Mitchell, Huichun Xu, May E Montasser, Ron Do, Eimear E Kenny, Ruth J F Loos, James G Terry, John Jeffrey Carr, Joshua C Bis, Bruce M Psaty, W T Longstreth, Kendra A Young, Sharon M Lutz, Michael H Cho, Jai Broome, Alyna T Khan, Fei Fei Wang, Nancy Heard-Costa, Sudha Seshadri, Ramachandran S Vasan, Nicholette D Palmer, Barry I Freedman, Donald W Bowden, Lisa R Yanek, Brian G Kral, Lewis C Becker, Patricia A Peyser, Lawrence F Bielak, Farah Ammous, April P Carson, Michael E Hall, Laura M Raffield, Stephen S Rich, Wendy S Post, Russel P Tracy, Kent D Taylor, Xiuqing Guo, Michael C Mahaney, Joanne E Curran, John Blangero, Shoa L Clarke, Jeffrey W Haessler, Yao Hu, Themistocles L Assimes, Charles Kooperberg, Jürgen Bernhagen, Christopher D Anderson, Scott M Damrauer, Ramin Zand, Jerome I Rotter, Paul S De Vries, Martin Dichgans
Rare Damaging Ccr2 Variants Are Associated With Lower Lifetime Cardiovascular Risk, Marios K Georgakis, Rainer Malik, Omar El Bounkari, Natalie R Hasbani, Jiang Li, Jennifer E Huffman, Gabrielle Shakt, Reinier W P Tack, Tamara N Kimball, Yaw Asare, Alanna C Morrison, Noah L Tsao, Renae Judy, Braxton D Mitchell, Huichun Xu, May E Montasser, Ron Do, Eimear E Kenny, Ruth J F Loos, James G Terry, John Jeffrey Carr, Joshua C Bis, Bruce M Psaty, W T Longstreth, Kendra A Young, Sharon M Lutz, Michael H Cho, Jai Broome, Alyna T Khan, Fei Fei Wang, Nancy Heard-Costa, Sudha Seshadri, Ramachandran S Vasan, Nicholette D Palmer, Barry I Freedman, Donald W Bowden, Lisa R Yanek, Brian G Kral, Lewis C Becker, Patricia A Peyser, Lawrence F Bielak, Farah Ammous, April P Carson, Michael E Hall, Laura M Raffield, Stephen S Rich, Wendy S Post, Russel P Tracy, Kent D Taylor, Xiuqing Guo, Michael C Mahaney, Joanne E Curran, John Blangero, Shoa L Clarke, Jeffrey W Haessler, Yao Hu, Themistocles L Assimes, Charles Kooperberg, Jürgen Bernhagen, Christopher D Anderson, Scott M Damrauer, Ramin Zand, Jerome I Rotter, Paul S De Vries, Martin Dichgans
Faculty, Staff and Student Publications
BACKGROUND: Previous work has shown a role of CCL2, a key chemokine governing monocyte trafficking, in atherosclerosis. However, it remains unknown whether targeting CCR2, the cognate receptor of CCL2, provides protection against human atherosclerotic cardiovascular disease.
METHODS: Computationally predicted damaging or loss-of-function (REVEL > 0.5) variants within CCR2 were detected in whole-exome-sequencing data from 454,775 UK Biobank participants and tested for association with cardiovascular endpoints in gene-burden tests. Given the key role of CCR2 in monocyte mobilization, variants associated with lower monocyte count were prioritized for experimental validation. The response to CCL2 of human cells transfected with these variants was tested …
Multikernel Embedded Fusion Unet (Mkef-Unet): A Robust Deep Learning Approach For Accurate Segmentation Of Chagas Parasites, Preet Kumar, Carlos Brito-Loeza, Lavdie Rada
Multikernel Embedded Fusion Unet (Mkef-Unet): A Robust Deep Learning Approach For Accurate Segmentation Of Chagas Parasites, Preet Kumar, Carlos Brito-Loeza, Lavdie Rada
Turkish Journal of Electrical Engineering and Computer Sciences
This paper introduces a novel approach for segmenting Chagas parasites on stained blood smear samples from mice during the acute phase of infection with Trypanosoma cruzi utilizing a U-Net-based deep learning model named multikernel embedded fusion UNet (MKEF-UNet). Our proposed model incorporates DenseNet-121 for feature extraction, a classifier module for predicting parasite information, and a segmentation decoder with multiscale feature fusion to generate precise segmentation results. Notably, the integration of the embedded vector module, multikernel convolutions with dilations, and advanced data augmentation techniques significantly enhance the model’s robustness and generalization capabilities. In extensive experiments on the Chagas dataset, MKEF-UNet achieves …
Trajectories Of Forced Vital Capacity In Patients With Systemic Sclerosis-Associated Interstitial Lung Disease, Oliver Distler, Madelon C Vonk, Arata Azuma, Maureen D Mayes, Dinesh Khanna, Kristin B Highland, Gerrit Toenges, Margarida Alves, Yannick Allanore
Trajectories Of Forced Vital Capacity In Patients With Systemic Sclerosis-Associated Interstitial Lung Disease, Oliver Distler, Madelon C Vonk, Arata Azuma, Maureen D Mayes, Dinesh Khanna, Kristin B Highland, Gerrit Toenges, Margarida Alves, Yannick Allanore
Faculty, Staff and Student Publications
We used data from the SENSCIS and SENSCIS-ON trials to assess decline in forced vital capacity (FVC) in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) who received long-term treatment with nintedanib and the effect of switching patients from placebo to nintedanib. In the SENSCIS trial, patients were randomised to receive nintedanib or placebo until the last patient reached week 52 but for ≤ 100 weeks. In SENSCIS-ON, the extension to SENSCIS, all patients received open-label nintedanib. Per protocol, the off-treatment period between these trials was ≤ 12 weeks. We assessed the trajectory of FVC in patients who received nintedanib …
Non-Canonical Splice Variants In Thoracic Aortic Dissection Cases And Marfan Syndrome With Negative Genetic Testing, David R Murdock, Dong-Chuan Guo, John S Depaolo, Ulrike Schwarze, Xue-Yan Duan, Alana C Cecchi, Isabella C Marin, Yingying Tang, Jessica X Chong, Michael J Bamshad, Kathleen A Leppig, Peter H Byers, Scott M Damrauer, Dianna M Milewicz
Non-Canonical Splice Variants In Thoracic Aortic Dissection Cases And Marfan Syndrome With Negative Genetic Testing, David R Murdock, Dong-Chuan Guo, John S Depaolo, Ulrike Schwarze, Xue-Yan Duan, Alana C Cecchi, Isabella C Marin, Yingying Tang, Jessica X Chong, Michael J Bamshad, Kathleen A Leppig, Peter H Byers, Scott M Damrauer, Dianna M Milewicz
Faculty, Staff and Student Publications
Individuals with heritable thoracic aortic disease (HTAD) face a high risk of deadly aortic dissections, but genetic testing identifies causative variants in only a minority of cases. We explored the contribution of non-canonical splice variants (NCVAS) to thoracic aortic disease (TAD) using SpliceAI and sequencing data from diverse cohorts, including 551 early-onset sporadic dissection cases and 437 HTAD probands with exome sequencing, 57 HTAD pedigrees with whole genome sequencing, and select sporadic cases with clinical panel testing. NCVAS were identified in syndromic HTAD genes such as FBN1, SMAD3, and COL3A1, including intronic variants in FBN1 in two Marfan syndrome (MFS) …
Sport, Soft Disempowerment And The 1966 Fifa World Cup, Richard Woodward
Sport, Soft Disempowerment And The 1966 Fifa World Cup, Richard Woodward
Articles
Sport is increasingly acknowledged as a vital component of the United Kingdom’s arsenal of soft power assets. However, the UK’s attempts to wring soft power from sport have met with mixed success. Many of the UK’s experiences align with an embryonic literature suggesting that sport, as well as enabling the production of soft power, is simultaneously capable of eroding it, a phenomenon dubbed ‘soft disempowerment’. Drawing upon original archival documents, this article examines how the Foreign, Commonwealth and Development Office (FCDO) commandeered the 1966 World Cup and England’s victory in the competition in a doomed attempt to communicate positive messages …