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Articles 53431 - 53460 of 1440090
Full-Text Articles in Entire DC Network
The Impact Of Ballet Techniques On Singing Performers, Julie H. Welch
The Impact Of Ballet Techniques On Singing Performers, Julie H. Welch
Theses and Dissertations
Singing performers are tasked to being a multifaceted artist using their acting and even dance skills in a performance. Voice teachers have long incorporated physical activity into training, but traditional ballet techniques—such as core tension and neck elongation—can contradict healthy singing practices. Given ballet’s deep historical connection to opera and stage performance, this study aims to examine whether integrating ballet into vocal training enhances or hinders a singer’s technique and overall performance. This investigation surveyed forty subjects who identified as teachers, singing performers, or students earning a performance degree and interviewing select subjects for further information; results will be discussed.
A Conductor’S Rehearsal And Performance Guide To Christopher Tin’S The Drop That Contained The Sea, Augusto Gil
A Conductor’S Rehearsal And Performance Guide To Christopher Tin’S The Drop That Contained The Sea, Augusto Gil
Theses and Dissertations
This document serves as a research resource regarding composer Christopher Tin and provides a conductor’s analysis for his large choral-orchestral work, The Drop That Contained the Sea. Christopher Tin is an American composer of film, television, and video game soundtracks. Though he is most likely best known for his choral-orchestral piece, “Baba Yetu”, written for the video game Civilization IV, Tin has written several choral-orchestral works that have premiered on international stages over the course of recent years, such as his large-scale song cycles Calling All Dawns, The Drop That Contained the Sea, To Shiver the Sky, and The Lost …
Assessing The Feasibility Of Transportable Nuclear Reactors: A Radiological Risk Case Study, Robert John Demuth
Assessing The Feasibility Of Transportable Nuclear Reactors: A Radiological Risk Case Study, Robert John Demuth
Theses and Dissertations
The feasibility of a truly transportable nuclear reactor presents significant radiological challenges that must be addressed to ensure compliance with regulatory limits and operational safety. This study evaluates the radiological constraints associated with the transportability of the Transportable Helium-cooled One-megawatt Reactor (THOR), focusing on neutron activation, shielding performance, and external radiation exposure. Using advanced radiation transport and activation modeling within the SCALE framework, a comprehensive analysis was conducted to quantify dose rates during operation, post-shutdown, and transport. A key aspect of this work involved assessing activation products in core materials, auxiliary components, and surrounding environments to determine their contribution to …
Transcrite Par L'Auteur: Analyzing And Performing The Piano-Vocal Scores Of Maurice Ravel's Operas, Jordan Knapp
Transcrite Par L'Auteur: Analyzing And Performing The Piano-Vocal Scores Of Maurice Ravel's Operas, Jordan Knapp
Theses and Dissertations
The two operas of Maurice Ravel, L’heure espagnole and L’enfant et les sortilèges, are, like most of the composer’s works, known for their innovative orchestrations and instrumental flourishes. However, the piano-vocal scores of the operas have their own unique qualities worthy of study. With the piano writing at times fiendishly difficult—standing toe-to-toe with Ravel’s solo piano music—the score demands simplification, particularly for less experienced performers serving as accompanist or rehearsal pianist for these works. Many sections of the music are impractical or even impossible for a single pianist to perform, but this study offers alternate solutions and simplifications for pianists …
Reclaiming The Body: Gender Politics And Embodied Meaning In Piano Performance And Pedagogy, Rachel Misheff
Reclaiming The Body: Gender Politics And Embodied Meaning In Piano Performance And Pedagogy, Rachel Misheff
Theses and Dissertations
This study examines the impact of the mind-body duality and its gendered metaphor on the lived experiences of historical and contemporary female pianists. Specifically, it explores how the principles of mind-body dualism have constructed gendered practices in piano performance and pedagogy that have both marginalized female pianists and engendered distinct embodied relationships to music. The study draws upon research from other disciplines, such as phenomenology, theories of embodiment, feminist theory, psychoanalysis, and Embodied Music Cognition, to examine how these gendered musical norms resulting from mind-body dualism functioned as forces of social inscription. This research, therefore, suggests that the body’s lived …
Understanding Water Washing Needs Of Hydrochar Generated From The Hydrothermal Carbonization Of Food Wastes To Establish Minimum Post-Processing Needs For Soil Amendment Application, Neve Renee Steger
Theses and Dissertations
Hydrothermal carbonization (HTC) is an advantageous and potentially environmentally beneficial approach for the conversion of wet biomass and waste streams into a value-added solid product referred to as hydrochar. Although hydrochar composition and properties generated from the carbonization of a variety of feedstocks have been well studied, there is a need for understanding whether hydrochar requires further refinement and/or treatment prior to being used in environmental applications, particularly when using the hydrochar as a soil amendment. Understanding the need for and extent of hydrochar post-treatment is critical in identifying environmentally beneficial and economically attractive strategies for hydrochar use. In this …
Activation Of Basal Forebrain Afferents Following Systemic Inflammation, Alexis Morgan Blas
Activation Of Basal Forebrain Afferents Following Systemic Inflammation, Alexis Morgan Blas
Theses and Dissertations
Sepsis is a large-scale immune response typically due to an imbalance of pro- and anti-inflammatory responses due to some type of infection or insult. Around 1.7 million adults in the United States will develop it each year, making it the leading cause of increased morbidity and mortality in hospitals. Sepsis can lead to many different symptoms, one of which is delirium. Delirium is a mental state of confusion and disorientation and involves delusions, hallucinations, memory issues, and most commonly inattention. Delirium is more prevalent in older individuals which leads to further complications and a higher likelihood of development of long-term …
Intimate Partner Violence In Post-Conflict Communities: The Case Of Peru, Karen Eliana León Negreiros
Intimate Partner Violence In Post-Conflict Communities: The Case Of Peru, Karen Eliana León Negreiros
Theses and Dissertations
Intimate partner violence (IPV) is a major public health issue worldwide and the most common type of violence experienced by women. In the last decade, a growing number of studies have evidenced that situations of civil conflict, post-conflict, and displacement can significantly exacerbate IPV and increase the likelihood of experiencing IPV later in life. This study expands on the literature by taking a Geographic Information System (GIS) mapping approach to understand how civil conflict violence in Peru (1980-2000) is associated with IPV rates in the country, 4 years (2004) and 19 years (2019) after the conflict. Study results evidence the …
Healing Histories: Implementing Trauma-Informed Care Practices In Libraries To Support Resilience And Recovery, Cearra Harris
Healing Histories: Implementing Trauma-Informed Care Practices In Libraries To Support Resilience And Recovery, Cearra Harris
Theses and Dissertations
This dissertation investigated the impact of public library closure on the Edgewood community in Columbia, South Carolina, an area with a rich history and significant ties to the two nearby historically Black Colleges and Universities (HBCUs), Benedict College and Allen University. It explored the intergenerational effects of historical trauma through the lens of collective memory, as documented in oral histories from community members and public library staff. The research aimed to understand the implications of the library's absence in a marginalized community context, emphasizing how such closures can exacerbate existing vulnerabilities. Through oral histories, questionnaires, and interviews, the findings reveal …
Automated Fiber Placement Laminate Level Optimization: A Physics-Inspired Method To Analyze Through-Thickness Defect Interactions, Nishan Patel
Theses and Dissertations
With the growing adoption of composite materials in industries such as aerospace, automotive, naval, wind energy, and even sectors like sports and consumer goods, there has been a strong push towards improving manufacturing reliability and productivity. One key method that has gained significant traction is Automated Fiber Placement (AFP), an additive manufacturing technique valued for its precision, efficiency, and adaptability in producing complex composite parts. As industries continue to shift from traditional metal-based structures to more advanced composite materials, the need for efficient and high- quality manufacturing solutions has become even more critical, prompting a focus on automation and optimization …
Stories Between The Stacks: Current Black Women School Librarians' Lived Experiences, Cynthia R. Johnson
Stories Between The Stacks: Current Black Women School Librarians' Lived Experiences, Cynthia R. Johnson
Theses and Dissertations
Black women school librarians navigate complex professional landscapes shaped by their lived experiences, intersecting identities, and systemic barriers. Despite their significant contributions to school librarianship, their perspectives remain largely absent from scholarly work. This qualitative study explored how the lived experiences and positionalities of Black women school librarians shape their practices. It addressed the critical gap in research on Black women school librarians. Grounded in Black Critical Theory (BlackCrit) and guided by Black feminist-womanist storytelling, this study employs a narrative approach to explore the experiences of four Black women school librarians in the Southeastern Region of the United States. Data …
Multiscale Modeling Techniques For Electrodynamic Systems, Hunter Teel
Multiscale Modeling Techniques For Electrodynamic Systems, Hunter Teel
Theses and Dissertations
In order to rapidly develop better electromagnetic and electrochemical systems, approaching these complicated topics from multiple perspectives is necessary. The use of mathematical models and numerical simulation offers the ability to evaluate and predict the performance of these systems based off the principles of electrodynamics in an ideal setting. Through the use of Computational Fluid Dynamics (CFD), representative geometries of scales can be created and evaluated to provide insight into the behavior of these systems. Simulation offers a modifiable environment that can approach the relevant physics from both the microscale and macroscale. Conclusions, results, boundary conditions, or other information from …
Child-Caregiver Relational Closeness And Child Mental Health In Nonparental Care Settings, Amanda Stafford Mcrell
Child-Caregiver Relational Closeness And Child Mental Health In Nonparental Care Settings, Amanda Stafford Mcrell
Theses and Dissertations
This dissertation examines child-caregiver relational closeness and child mental health within nonparental care systems in Low- and Middle-Income countries (LMICs). Five key factors impacting the well-being of orphaned, separated, and vulnerable children in LMICs are explored using the Positive Outcomes for Orphans (POFO) dataset: child maltreatment, social support, child-caregiver relationships, and nonparental care systems. First, I examined the relationship between maltreatment, social support, and mental well-being. Findings showed that maltreatment was associated with lower mental well-being, where social support (emotional support, tangible support, positive social support) was associated with greater mental well-being, even in the concurrent presence of maltreatment. Second, …
Investigation Of The Hdl Molecular Architecture Before And After Exercise Training., Prasun Kumar Dev
Investigation Of The Hdl Molecular Architecture Before And After Exercise Training., Prasun Kumar Dev
Theses and Dissertations
The functional characteristics of high-density lipoprotein (HDL) particles are influenced by their structure, including their molecular composition (e.g. HDL lipidome and proteome). However, the effects of exercise training on HDL molecular composition and its relationship with HDL-related traits are largely unknown. In this ancillary study, we investigated the HDL lipidome and proteome of 154 adults before and after 20 weeks of exercise training in the HERITAGE Family Study. The HDL-sized plasma fraction was isolated utilizing FPLC-SEC, followed by untargeted lipidomic and proteomic analysis using LC/MS. We identified 341 known lipid species while 409 HDL associated proteins. Clinical and functional related …
Essays On Platform Operations: Applications In Service Operations And Sustainability, Timothy Campbell Clarkson
Essays On Platform Operations: Applications In Service Operations And Sustainability, Timothy Campbell Clarkson
Theses and Dissertations
Online platforms inhabit every corner of daily life, from social media, to medicine, to retail, and everything in between. Platform owners are met with a litany of challenges as they seek to maximize the platform's value and implement novel strategies to foster widespread adoption. This dissertation focuses on empirically assessing the impact of online platforms in both sustainability and service operations contexts. In the first chapter, we examine the impact of introducing an agricultural advisory platform on smallholder farmer potato production in a single district in Rural India. We find positive impacts to overall production, and we explore the mechanism …
Hallucinations In Large Foundation Models: Characterization, Quantification, Detection, Avoidance, And Mitigation, Vipula Rawte
Hallucinations In Large Foundation Models: Characterization, Quantification, Detection, Avoidance, And Mitigation, Vipula Rawte
Theses and Dissertations
Deception is an inherent aspect of social interactions, with research indicating that most people engage in deceptive behavior at least once or twice daily . In parallel, advances in artificial intelligence have led to machines exhibiting deceptive tendencies. These deceptions can be categorized into two types: unintended and intentional. Unintended deceptions - often referred to as hallucinations - occur when generative AI systems produce plausible and convincing narratives yet are factually inaccurate. This phenomenon primarily results from the systems' architectural design, extensive parametric memory, and reliance on statistical assumptions. In this thesis, we provide a comprehensive discussion on the characterization, …
A Novel Geometric Modeling Kernel For Automated Fiber Placement, Rowen Burney
A Novel Geometric Modeling Kernel For Automated Fiber Placement, Rowen Burney
Theses and Dissertations
Automated Fiber Placement (AFP) is a key manufacturing technique for producing high-performance composite structures, yet existing geometric modeling frameworks lack the specialized functionality required for efficient toolpath planning and laminate optimization. This work presents Knots, a Geometric Modeling Kernel (GMK) developed specifically to address these limitations by providing a unified geometric foundation tailored for AFP. Unlike general-purpose Computer Aided Design (CAD) libraries, Knots is optimized for AFP, offering specialized geometric operations that streamline the transition from design to manufacturing. It directly manages the loading and computation of geometric data, ensuring structured laminate generation while supporting automation and scripting for improved …
Translating Theory Into Practice: Mediating Academic Advising Reform At Scale Through Improvement Science, Joshua Black
Translating Theory Into Practice: Mediating Academic Advising Reform At Scale Through Improvement Science, Joshua Black
Theses and Dissertations
Improving student outcomes at community colleges is a difficult, multifaceted problem. While no single approach can be a panacea for such a challenging problem of practice, Guided Pathways (GP) research suggests a scalable reform model that may ultimately help to improve the underlying systems and structures colleges have designed to support their students, and in turn, may help colleges to achieve the goal of improved student outcomes more consistently. Because of the breadth of the GP model’s recommendations for reform, however, implementation is complex. To be effective, each of the reforms must be localized, adopted, and brought to scale within …
Frequency-Based Rapid Structural Damage Detection Using Embedded Edge Computing On Resource-Constrained Devices, Ryan Yount
Theses and Dissertations
Structural Health Monitoring (SHM) is essential for ensuring reliability and longevity of useful structures. Traditional SHM approaches rely on manual or remote data transmission and external processing, which introduce latency and can depend on stable communication links. This work aims to advance SHM by integrating edge-computing techniques for rapid damage detection to enable faster and more autonomous structural assessments in resource-constrained environments. The research spans three key contributions including 1) frequency-based damage detection of civil structures using a sensor package with the addition of an edge processor, 2) additions to the computational efficiency of the edge-computing sensor package in a …
Unveiling Belonging: Women Entrepreneurs’ Belonging Strategies To Navigate The Embedding Process, Saskia Stoker, Ana Cruz-Garcia, Ingrid Wakkee
Unveiling Belonging: Women Entrepreneurs’ Belonging Strategies To Navigate The Embedding Process, Saskia Stoker, Ana Cruz-Garcia, Ingrid Wakkee
Dept. of Marketing & International Business Publications
Purpose
Opportunity-driven women entrepreneurs encounter gendered challenges in leveraging social networks essential for business development. This research builds on Stead (2017), exploring how women navigate these challenges and foster belonging within these networks. Utilising a post-structural feminist lens, we aim to understand the strategies employed by women entrepreneurs to maintain embeddedness in social networks. Our findings contribute to an understanding of the complex interplay between gender, belonging strategies and embeddedness in entrepreneurship.
Design/methodology/approach
This study draws on in-depth interviews (31) with opportunity-driven women entrepreneurs. Thematic analyses were conducted to capture the women’s understandings of belonging and embedding in social networks …
An Examination Of Karl Barth’S Critique Of Natural Theology: The Epistemological Shift Post-Salvation, Luke D. Pelkey
An Examination Of Karl Barth’S Critique Of Natural Theology: The Epistemological Shift Post-Salvation, Luke D. Pelkey
Selected Honors Theses
This thesis reexamines Karl Barth’s rejection of natural theology, specifically if his Christocentric framework allows for a limited, post-salvific engagement with natural revelation. While Barth is adamant in his denial of the source of knowledge of God being found solely through reason, logic, or nature, this thesis argues that Barth does not reject the possibility of natural revelation but rejects its accessibility. But, due to the effects of salvation on not just the soul but the whole of one’s being, the mind is also renewed, allowing for the noetic effects of sin to be overcome. Drawing from Church Dogmatics I/1, …
Visiting The Birmingham Civil Rights Institute, Circa 2000, Uab Archives
Visiting The Birmingham Civil Rights Institute, Circa 2000, Uab Archives
Images of the Month from UAB Archives
Image ID: UAB campus publication
UAB receives approval of a bachelor's degree in African American Studies, 2000
Importance Of Postreduction Ct Scans In Posterior And Transverse Posterior Wall Acetabular Fracture-Dislocations, Samantha R Gardner, Douglas R Haase, Nikhil Gattu, Stephen J Warner, Milton L Chip Routt, Patrick Kellam, Jonathan G Eastman
Importance Of Postreduction Ct Scans In Posterior And Transverse Posterior Wall Acetabular Fracture-Dislocations, Samantha R Gardner, Douglas R Haase, Nikhil Gattu, Stephen J Warner, Milton L Chip Routt, Patrick Kellam, Jonathan G Eastman
Faculty, Staff and Student Publications
Objectives: To report the frequency of patients with pre-reduction and postreduction computed tomography (CT) scans associated with acetabular fracture-dislocations and the change in position of associated intra-articular fragments occurring with joint reduction.
Design: Retrospective case series.
Setting: Regional Level 1 trauma center.
Patient selection criteria: Patients who sustained Arbeitsgemeinschaft fur Osteosynthesefragen/Orthopedic Trauma Association 62A1 and 62B1 posterior wall or transverse posterior wall acetabular fracture-dislocations with pre-reduction and postreduction CT imaging from February 2020 to July 2023.
Outcome measures and comparisons: Intra-articular fragments were identified, and change in position (fossa to cranial, intra-articular to extra-articular, etc.) was noted from pre-reduction to …
Uric Acid Stroke Cerebroprotection Transcended Sex, Age, And Comorbidities In A Multicenter Preclinical Trial, Rakesh B Patel, Mariia Kumskova, Hanish Kodali, Ivan Budnik, Vitalii Kuznetsov, Aditi Jain, Abhishek Jha, Daniel Thedens, Nirav Dhanesha, Brijesh Sutariya, Karisma A Nagarkatti, Jessica Lamb, Pradip Kamat, Yanrong Shi, Brooklyn Avery, Takahiko Imai, Xuyan Jin, Anjali Chauhan, Ligia S B Boisserand, Mohammad B Khan, Krishnan Dhandapani, Basavaraju G Sanganahalli, Lauren H Sansing, David C Hess, Raymond C Koehler, Louise D Mccullough, Jaroslaw Aronowski, Cenk Ayata, Márcio A Diniz, Patrick D Lyden, Anna M Planas, Angel Chamorro, Anil K Chauhan, Enrique C Leira, Span Investigators
Uric Acid Stroke Cerebroprotection Transcended Sex, Age, And Comorbidities In A Multicenter Preclinical Trial, Rakesh B Patel, Mariia Kumskova, Hanish Kodali, Ivan Budnik, Vitalii Kuznetsov, Aditi Jain, Abhishek Jha, Daniel Thedens, Nirav Dhanesha, Brijesh Sutariya, Karisma A Nagarkatti, Jessica Lamb, Pradip Kamat, Yanrong Shi, Brooklyn Avery, Takahiko Imai, Xuyan Jin, Anjali Chauhan, Ligia S B Boisserand, Mohammad B Khan, Krishnan Dhandapani, Basavaraju G Sanganahalli, Lauren H Sansing, David C Hess, Raymond C Koehler, Louise D Mccullough, Jaroslaw Aronowski, Cenk Ayata, Márcio A Diniz, Patrick D Lyden, Anna M Planas, Angel Chamorro, Anil K Chauhan, Enrique C Leira, Span Investigators
Faculty, Staff and Student Publications
Background: Past failures in translating stroke cerebroprotection provoked calls for a more rigorous methodological approach, leading to the stroke preclinical assessment network SPAN (Stroke Preclinical Assessment Network), where uric acid (UA) treatment exceeded a prespecified efficacy boundary for the primary functional outcome. Still, successful translation to humans requires confirmation of the effect of UA across key biological variables relevant to patients with stroke.
Methods: We measured the effects of intravenous UA treatment (16 mg/kg) versus intravenous saline in groups of animals enrolled in the SPAN network with diverse comorbidities, sex, and age. The masked study drug or placebo was administered …
Opportunities In Stroke Care At Safety Net Hospitals: A Socioecological Perspective, Anjail Sharrief, Joshua Wollen, Maha Almohamad, M Carter Denny, Erica Jones, Aardhra M Venkatachalam, Digvijaya Navalkele, Shivika Chandra, Mariam Ahmed, Robert Pratt, Bradley D Shy, John Mcmenamy, Chigozirim Izeogu, Lesli E Skolarus, Nneka L Ifejika, Nicole R Gonzales
Opportunities In Stroke Care At Safety Net Hospitals: A Socioecological Perspective, Anjail Sharrief, Joshua Wollen, Maha Almohamad, M Carter Denny, Erica Jones, Aardhra M Venkatachalam, Digvijaya Navalkele, Shivika Chandra, Mariam Ahmed, Robert Pratt, Bradley D Shy, John Mcmenamy, Chigozirim Izeogu, Lesli E Skolarus, Nneka L Ifejika, Nicole R Gonzales
Faculty, Staff and Student Publications
Safety net hospitals (SNHs) provide care to patients regardless of their insurance status or ability to pay, serving populations at the highest risk for poor stroke outcomes. These include historically marginalized racial and ethnic groups, and individuals disproportionately affected by adverse social drivers of health, including lower socioeconomic status, housing instability, and limited access to preventive care. Improving stroke care at SNHs presents a critical opportunity to strengthen care delivery for individuals with the greatest need. However, such efforts require a clear understanding of the barriers across all levels of the healthcare system. In this Perspective, the authors adopt a …
Fungal Infections In People Who Use Drugs, Jose Portugal Gonzales, Luis Ostrosky-Zeichner
Fungal Infections In People Who Use Drugs, Jose Portugal Gonzales, Luis Ostrosky-Zeichner
Faculty, Staff and Student Publications
Illicit drug use in the United States continues to rise, alongside an increasing number of severe infections associated with drug use. Surveillance studies report that 28%–34% of candidemia cases are linked to intravenous drug use, with Candida albicans being the most commonly isolated species, followed by Candida parapsilosis and Candida glabrata. Marijuana use is associated with lung infections caused by Aspergillus and the Mucorales, showing a 3.5-fold increased risk of mold infections and a 2.2-fold increased risk for other fungal infections. Intravenous drug use also presents a recognized risk factor for Aspergillus and Mucorales infections. Additionally, substances like …
Acute Pain Trajectories In Elderly Patients With Fragility Hip Fractures, Paul Potnuru, Christina Goehl, Katherine S Becker, Alejandro Juul, Madison Aycock, Johanna Blair De Haan, Sudipta Sen, Michelle Ge, Stephen J Warner, Nadia Hernandez
Acute Pain Trajectories In Elderly Patients With Fragility Hip Fractures, Paul Potnuru, Christina Goehl, Katherine S Becker, Alejandro Juul, Madison Aycock, Johanna Blair De Haan, Sudipta Sen, Michelle Ge, Stephen J Warner, Nadia Hernandez
Faculty, Staff and Student Publications
Background: Pain management for hospitalized elderly patients with fragility hip fractures (FHF) remains challenging. This study aims to distinguish acute pain trajectories in FHF patients that can inform personalized analgesia management.
Methods: We conducted a prospective observational study of patients aged 65 and older with FHF at a Level I trauma center. The primary outcome was daily average pain assessed for five days post-injury using the Brief Pain Inventory (BPI). We used group-based trajectory modeling (GBTM) to distinguish acute pain trajectories. Then, factors and secondary outcomes (opioid use and hospital length of stay [LOS]) associated with more severe pain trajectories …
Thrombotic Complications Associated With Right Atrial Lines In Neonates And Infants Undergoing Cardiac Surgery. Is Calcium Chloride A Culprit?, Vy A Tran, Evelyn M Griffin, Jehan D Elliott, Rebecca L Scholl, Robert B Hill, Kelbie Kerr, Hala Khan, Jonathan Bates, Xu Zhang, Sepideh Saroukhani, Jorge Salazar, Olga I Pawelek
Thrombotic Complications Associated With Right Atrial Lines In Neonates And Infants Undergoing Cardiac Surgery. Is Calcium Chloride A Culprit?, Vy A Tran, Evelyn M Griffin, Jehan D Elliott, Rebecca L Scholl, Robert B Hill, Kelbie Kerr, Hala Khan, Jonathan Bates, Xu Zhang, Sepideh Saroukhani, Jorge Salazar, Olga I Pawelek
Faculty, Staff and Student Publications
Objectives: To determine if a change from calcium chloride to calcium gluconate infusion resulted in a decreased incidence of atrial thrombi and thrombotic events in neonates undergoing cardiac surgery.
Design: A single-center, retrospective cohort analysis.
Setting: A single center in Houston, TX.
Participants: 135 neonates undergoing cardiac surgery who had either a central venous catheter or tunneled atrial catheter placed and received infusions of either calcium chloride or calcium gluconate in the perioperative period.
Interventions: Patients either received a calcium chloride or calcium gluconate infusion in the perioperative period.
Measurements and main results: The study cohort consisted of 93 procedures …
The Placenta Regulates Intrauterine Fetal Growth Via Exosomal Pparγ, Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D Kilby, Rodney E Kellems, Xiujun Fan, Yang Xia, Philip N Baker, Hongbo Qi, Chao Tong
The Placenta Regulates Intrauterine Fetal Growth Via Exosomal Pparγ, Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D Kilby, Rodney E Kellems, Xiujun Fan, Yang Xia, Philip N Baker, Hongbo Qi, Chao Tong
Faculty, Staff and Student Publications
Abnormal adipogenesis is a major contributor to fetal growth restriction (FGR) and its associated complications. However, the underlying etiology remains unclear. Here, it is reported that the placentas of women with pregnancies complicated with FGR exhibit peroxisome proliferator-activated receptor γ (PPARγ) inactivation. In mice, trophoblast-specific ablation of murine PPARγ reproduces the phenotype of human fetuses with FGR and defective adipogenesis. Coculture of trophoblasts with preadipocytes significantly improves preadipocyte commitment and differentiation and increases the transcription of a series of adipogenic genes via intercellular transfer of exosomal PPARγ proteins. Moreover, nanoparticle-mediated placenta-specific delivery of rosiglitazone (RGZ) significantly rescues adipogenesis defects in …
Calcium-Sensing Receptor As A Novel Target For The Treatment Of Idiopathic Pulmonary Fibrosis, Kasope Wolffs, Renjiao Li, Bethan Mansfield, Daniel A Pass, Richard T Bruce, Ping Huang, Rachel Paes De Araújo, Bahareh Sadat Haddadi, Luis A J Mur, Jordanna Dally, Ryan Moseley, Rupert Ecker, Harry Karmouty-Quintana, Keir E Lewis, A John Simpson, Jeremy P T Ward, Christopher J Corrigan, Renata Z Jurkowska, Benjamin D Hope-Gill, Daniela Riccardi, Polina L Yarova
Calcium-Sensing Receptor As A Novel Target For The Treatment Of Idiopathic Pulmonary Fibrosis, Kasope Wolffs, Renjiao Li, Bethan Mansfield, Daniel A Pass, Richard T Bruce, Ping Huang, Rachel Paes De Araújo, Bahareh Sadat Haddadi, Luis A J Mur, Jordanna Dally, Ryan Moseley, Rupert Ecker, Harry Karmouty-Quintana, Keir E Lewis, A John Simpson, Jeremy P T Ward, Christopher J Corrigan, Renata Z Jurkowska, Benjamin D Hope-Gill, Daniela Riccardi, Polina L Yarova
Faculty, Staff and Student Publications
Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis and no curative therapies. Fibroblast activation by transforming growth factor β1 (TGFβ1) and disrupted metabolic pathways, including the arginine-polyamine pathway, play crucial roles in IPF development. Polyamines are agonists of the calcium/cation-sensing receptor (CaSR), activation of which is detrimental for asthma and pulmonary hypertension, but its role in IPF is unknown. To address this question, we evaluated polyamine abundance using metabolomic analysis of IPF patient saliva. Furthermore, we examined CaSR functional expression in human lung fibroblasts (HLFs), assessed the anti-fibrotic effects of a CaSR antagonist, NPS2143, in TGFβ1-activated normal …