Digital Commons Network^™

Predictive Toxicological Analysis Of Novel Prostate Cancer Drug, Dani Sheil

Undergraduate Student Symposium

Prostate cancer is the second-leading cause of cancer-related death in men in the United States, claiming approximately 1 in 44 lives. While novel cancer therapies aim to selectively target cancer cells, minimizing damage to healthy tissues, these treatments can still cause significant side effects. The drug discovery process remains costly and time-intensive, with only 10-20% of compounds making it from clinical trials to market, often due to toxicity issues that arise during later-stage testing. To address this, computational methods in predictive toxicology can expedite drug development by assessing potential toxic effects early, reducing costs and risks. In this study, we …

Psychedelic Substituted Phenethylamine Alters Human Neural Progenitor Cell Morphology, Proliferation, And Survival, Omar E. Saleh, Grace K. Wong, Chase A. Gonzales, Mark Apterman, Laury Pierre, Stacey Doret, Isaac Hai, Travis J.A. Craddock

Undergraduate Student Symposium

Examining how psychedelic substituted phenethylamines affect neural plasticity is key to understanding harms and potential medical implications of recreational drugs. The microtubule cytoskeleton has been proposed to modulate the effects of phenethylamines as a downstream effector and through scaffolding mechanisms. Microtubules play a crucial role in neurite outgrowth, protein transport, and synaptic stability in cells. Our group has shown that specific psychedelic substituted phenethylamines (25B-NBF, 25C-NBF, and DMBMPP) alter microtubule formation in a dose-dependent manner. As these phenethylamines limit microtubule capacities, they may impact cytoskeletal-mediated neural plasticity. This study’s purpose is to determine if substituted phenethylamines, 25B-NBF, 25C-NBF, and DMBMPP …

Role Of Exosomes In Gulf War Illness, Chetana Movva, Lily Tehrani, Joshua Frank

Undergraduate Student Symposium

Gulf War Illness (GWI) is a multi-symptom chronic disorder affecting over 200,000 veterans deployed during the Gulf War from 1990-1991. GWI veterans deployed during the Persian Gulf War were exposed to multiple chemical warfare agents. Veterans with GWI experience chronic pain, fatigue, neurocognitive symptoms, gastrointestinal (GI) disturbances, etc. GWI-associated biomarkers have revealed a proinflammatory biomarker signature, a discovery that has recently led to research further exploring the inflammatory response within GWI patients.

Exosomes are small extracellular particles that range in diameter between 50-200 nm and have specific markers. Exosomes contain DNA, proteins, and RNA and carry this information from one …

Seizure Vulnerability In A C. Elegans Obesity Model, Carina Pavlov, Jeremy Ignatius, Scarlet Jinhong Park Ph.D.

Undergraduate Student Symposium

Metabolic disorders such as diabetes mellitus, characterized by hyperglycemia due to defects in insulin secretion, affect millions of people and increasingly more. Epidemiological studies have shown that individuals with diabetes have a higher risk of developing epilepsy, a neurological disorder where recurrent seizures occur. Conversely, many antiepileptics affect glucose and lipid metabolism.

The nematode Caenorhabditis elegans (C. elegans) is a model organism suited for studying metabolic and neurological disorders, due to its genetic tractability, short life cycle, and conserved signaling pathways. Although previous studies have developed and used genetic and diet-induced obesity models in C. elegans, none …

Sgi-1027 Small Molecule Inhibits Dnmt And Promotes P21-Mediated Apoptosis Via Epigenetic Alterations In Sk-N-Sh Neuroblastoma Cells, Sadhna Seth, Anika Singh, Shyam Sundar Jaganathan Ph.D.

Undergraduate Student Symposium

Neuroblastoma is an aggressive childhood cancer originating from neural crest cells. Treatment for high-risk neuroblastoma includes chemotherapy. Emerging evidence indicates that DNMT inhibitor codenamed SGI-1027 may facilitate cell cycle arrest and induce apoptosis by modulating cell cycle regulatory pathways. Therefore, we hypothesize that SGI-1027 treatment could lead to apoptosis mediated cell death in SK-N-SH cells through the upregulation of p21 transcription.

This study investigated whether SGI-1027, a DNA methyltransferase inhibitor, causes DNA methylation and upregulation of p21 through a p53-independent pathway, which could lead to cell cycle arrest and intrinsic-pathway mediated apoptosis in SK-N-SH cells. To assess the effects of …

Social Humanoids And Human Interactions: Investigating The Role Of Trust, Persuasion, And Empathy In Fostering Healthy Behaviors Among College Students, Nitya Alaparthy, Anvita Kalepalli, Walter Chang, Vinay Manlapudi, Savri Patel

Undergraduate Student Symposium

The exposure of social humanoid robots introduces a wide variety of interactive opportunities by utilizing Artificial Intelligence (AI)-powered automatons/automated machines to enhance both the quality and simplicity of human lives. Using AI systems, humanoid robots can be programmed to execute various tasks autonomously, ranging from assisting with administrative and clerical tasks, clinical and healthcare tasks, social interaction and emotional support tasks, as well as educational and training tasks, amongst others. With successful integration into healthcare settings, current research explores employing social humanoids to add social dimensions to patient care, fostering human-like interactions. Researchers are assessing the quality of interactions between …

Solvent Effect On The Stabilization Of The Monoprotonated Species Of Tetraphenylporphyrin, Pablo Perez, Dani Sheil

Undergraduate Student Symposium

The protonation of Tetraphenylporphyrin (TPP) demonstrates unusual behavior where protonation causes only the formation of a diprotonated species. This behavior is due to a change in conformation leading to an unstable saddle deformation in which the monoprotonated species is highly unfavorable. The stabilization of the unfavored conformation in the monoprotonated intermediate species may be achieved by understanding the effects of different solvents on the protonation of TPP. This study was done to explore the protonation of TPP using Toluene Chloroform, and Dichloromethane using trifluoroacetic acid and chloroacetic acid to analyze the effects of the different solvents. Using a UV spectrophotometer, …

Spliceosomal Modulation Induces Immunogenicity Of Melanoma Cells And In Vivo Immune Response, Sadeeshkumar Velayutham, Shweta Shah, Tulsi Desai, Keiran S.M. Smalley Ph.D., Aveta Singh Ph.D., Jun Yong Choi Ph.D.

Undergraduate Student Symposium

Melanoma is an aggressive skin cancer with high mortality rates, often driven by BRAF and NRAS mutations. While targeted therapies like Vemurafenib have improved outcomes in BRAF-mutant melanoma, resistance and adverse effects limit their long-term efficacy. There is an urgent need for novel therapeutic approaches to overcome these challenges. This study investigates the efficacy of novel anti-melanoma compounds, 2155-14 and 2155-18, targeting spliceosomal proteins, in a xenograft model derived from the A375 BRAF/NRAS double mutant cell line. Seven-week-old mice were implanted with A375 BRAF/NRAS mutant cells and treated with 2155-14 or 2155-18. Treatments were administered subcutaneously thrice weekly. Tumor growth …

Student Perception Of Ai And Its Effect On Creativity, Jade Sanchez, Juman Hai

Undergraduate Student Symposium

With the rise of Artificial Intelligence, it is important to investigate its impact on how this will affect students. Our study aimed to see how generative artificial intelligence (AI) affects student creativity levels. We hypothesized that as students use of AI increases, their creativity levels decrease. We collected data from participants’ demographics, their scores on the Short Scale of the Creative Self, an AI usage survey, and the Alternative Use Task (AUT). The creativity survey had subscales for Creative Self-efficacy, Personal Identity, and Self-concept. We also created subscales for ethical and unethical AI usage. Our data showed that there was …

Synergistic Effects Of Quercetin And Lutein In Tagetes Erecta Against Antibiotic-Resistant Microorganisms, Ninoshka I. Garcia Torres

Undergraduate Student Symposium

The increasing global problem of antibiotic resistance has driven the need to look for innovative classes of antimicrobial agents. Phytochemicals isolated from Tagetes erecta, such as Quercetin, a flavonoid, and lutein, a carotenoid, have antimicrobial properties against bacteria through various mechanisms, such as disruption of bacterial membrane integrity, production of reactive oxygen species, and biofilm inhibition. Quercetin and lutein also improve the effectiveness of standard antibiotics, indicating their usability as adjuvants against resistant microbes such as Staphylococcus aureus and Pseudomonas aeruginosa. Despite their potential, several challenges need to be addressed, including the fluctuating yield production of phytochemicals, the …

Synthesizing Ferrocene Bipyridine Adducts For The Creation Of New Metal Based Photosensitizing Complexes, Gabrielle Spankus, Jarlynn Ramirez

Undergraduate Student Symposium

Metal-based photosensitizers commonly use bipyridine molecules and their ligands. Their absorption and chemical properties can be tuned through substitutions. This study synthesized a ferrocene appended 2,2 -bipyridine dimer (Fc-bipy2-Fc) using palladium(0)-catalyzed Suzuki-Miyaura cross coupling reaction to create new photosensitizing molecule that could further complex with metals such as ruthenium to enhance photophysical and electronic properties. The product was purified by flash chromatography and characterized by NMR, FTIR, UV-Vis, and fluorescence spectroscopy.

Targeting Glioblastoma Stem Cells: Structure-Activity Relationship Of Potent Diaryl Acrylonitrile Resveratrol Analogs, Brianna Calderon, Alma Partenza, Neha Jasti, Saya Seraj, Nhi Van, Daniela Otero-Wincher, Elaine Chen, Xavier Pantig, Sabrin Safar, Maria Moreno Hollweg, Eduardo Véliz Ph.D., Steven Vanni Ph.D., Venkatesh Shanbhag Ph.D.

Undergraduate Student Symposium

Glioblastoma (GBM) is an aggressive brain tumor that presents significant treatment challenges due to its infiltrative nature and therapy resistance. Elimination of GBM stem cells (GSCs), which drive tumor progression and treatment resistance, is essential for a successful outcome. Resveratrol (RSV), a natural compound with anticancer properties, shows limited therapeutic potential due to poor bioavailability, prompting the development of more potent analogs. In this study, 80 diaryl acrylonitrile RSV analogs were synthesized via Knoevenagel condensation and evaluated for their cytotoxicity toward GSCs using MTS assay. Among these compounds, E03 exhibited notable activity, with an average GSC IC50 value of 106 …

Telemedicine For Post-Stroke Rehabilitation Impact Patient Quality Of Life Compared To Traditional In-Person Therapy, Rani Mehta, Shreya Katapally

Undergraduate Student Symposium

Background: The World Health Organization (WHO) reports that stroke accounts for around 11% of all deaths globally. Stroke rehabilitation plays a crucial role in helping patients recover and regain lost function, offering the potential for improved quality of life after a stroke. Unfortunately, in-person therapy can be challenging to access due to lack of transportation, financial burden, and geographical barriers. Telemedicine offers an alternative solution, allowing patients to receive therapy at the convenience of their home.

Research Question: What are the differences in recovery outcomes over time between stroke patients receiving telemedicine-guided physical therapy and those receiving in-person physical therapy? …

The Development, Ethical Controversies, And Importance Of Xenotransplantation, Dakota Koenig

Undergraduate Student Symposium

Xenotransplantation, the use of animal organs in human patients, is one of the newest developments in allotransplantation (Chisholm-Burns, 2024). Due to genetic similarities, pig livers and hearts could be used in patients waiting for a transplant. While these organs seem like the perfect solution, the organs must still be genetically altered to be used in human patients. Scholars like Thom et al (2023) explain how specific genes must be added to or removed from the pig’s genome to make the organs suitable for human transplants. While the idea seems to be a positive way to shorten the list of those …

The Effects Of Early Mobilization On Rotator Cuff Tears: A Meta Analysis, Colton Batz

Undergraduate Student Symposium

The purpose of this research is to assess post-surgical early mobilization of the rotator cuff compared to conservative treatment and the impact on return-to-participation. BACKGROUND: Rotator cuff tears are common upper-body injuries in sports such as baseball, volleyball, and handball, requiring surgical intervention in 21% of reported rotator cuff tears among volleyball players, and often dependent on tear size and severity of tear among athletes. Although, some post-surgical rehabilitation programs may provide quicker return-to-participation times compared to others, further research may provide insight into the impact of early mobilization. (P:) Rotator cuff patients looking for effective and prompt …

The Effects Of Lysogenic Bacteriophages On Gordonia Rubripertincta Superinfection Immunity, Nathalia Gonzalez, Harami Athwale, Joshua Dinh, Rithvik Jarugula, Julian Oliver Bozek, Julia St. Clair, Mitchell Thenor

Undergraduate Student Symposium

Antibiotic resistance is a growing concern in the field of medicine, making an increasing demand for alternative treatments to antibiotics. One option is phage therapy, the use of viruses that specifically kill bacteria. Bacteriophages present two life cycles: lytic, where they rupture the cell, and lysogenic, where they sneak into the host's DNA and remain dormant. Temperate phage can alternate between the two life cycles and when lysogenic can prevent other phages from infecting the bacteria, providing the bacteria with superinfection immunity. This lowers phage therapy’s effectiveness. Our goal is to determine if novel phages that infect Gordonia rubripertincta, …

The Effects Of Turkesterone On Isometric Muscular Strength, Alyana Andal

Undergraduate Student Symposium

Introduction: The supplementation of Turkesterone, a phytoecdysteroid, has been suggested to have the anabolic capability to enhance muscular growth thereby increasing muscular strength. The purpose of this study was to investigate the effects of Turkesterone supplementation on the isometric muscular strength of active males and females after four weeks of daily dosage.

Methods: The sample of this randomized, double-blind, placebo-controlled trial consisted of thirty-one males (n=14) and females (n=17) who were physically active. Participants orally consumed 500 mg of turkesterone (Ajuga Extract) or a placebo (rice flour) daily for four weeks. The handgrip strength of each participant was measured (i.e., …

The Effects Of Turkesterone Supplementation On Body Composition, Ava Lukowiak

Undergraduate Student Symposium

It has been proposed that turkesterone supplementation can cause an increase in muscle mass and overall improvements in body composition. Turkesterone is a phytoecdysteroid derived from plants such as common wheat (Triticum aestivum) and Vitex plants (sage and mint). The purpose of this study was to determine if turkesterone supplementation in healthy, active males and females can increase lean muscle mass. This randomized, double-blind, controlled trial consisted of thirty-one physically active males (n=14) and females (n=17). Muscle mass was determined pre-test and post-test using a dual-energy Xray absorptiometry machine (DEXA). The treatment group ingested 500 milligrams of turkesterone daily for …

The Impact Of Doula Support On Maternal Mental Health, Neonatal Outcomes, And Epidural Use: Correlation With Mental Health Inventory-5 And Apgar Scores, Katherine Dookhan, Eesha Ramisetti, Rosselyn Perez, Rhea Hede-Sakhardande

Undergraduate Student Symposium

Maternal and neonatal health disparities disproportionately affect Black and biracial women in underserved communities, with higher rates of mental health challenges and adverse neonatal outcomes. This longitudinal cohort study examines the impact of doula support on maternal mental health, neonatal outcomes, and epidural use during labor. Participants are recruited from the Urban League of Broward County and the Broward Healthy Start Coalition in Florida and divided into two groups: those receiving doula support from 16 weeks of pregnancy to one month postpartum and those receiving standard care. Outcomes are assessed using the Mental Health Inventory-5 (MHI-5) for maternal mental health, …

The Role Of Future Time Perspective And Social Support In Shaping Psychological Well-Being During Emerging Adulthood, Amala Vadukumcherry, Japji G. Madan, Kaleigh Cummings, Riya Vadaliya

Undergraduate Student Symposium

The present study explores the associations between future time perspective and perceptions of social support and their influence on psychological well-being in emerging adulthood. The sample consisted of 334 emerging-adults between the ages of 18-25(average-age18.76years, 267women). Subjects completed self-report measures of future time perspective, perceptions of social support, and psychological well-being.

Regression-results indicate that social-support and future time perspective together predict psychological well-being. Follow up tests using the procedures recommended by Aiken and West (1991) indicate that social support moderated the links between future time perspective and psychological well-being.

Specifically, emerging-adults with low-medium family support who see their future as …

The Universal Mass Function And Its Applicability To Organic Molecules, Gabrielle Andrews, Taylor Butler

Undergraduate Student Symposium

The ability to predict the yield when synthesizing an organic molecule is a challenging issue in organic chemistry and a major obstacle when planning multi-step organic synthesis. The Universal Mass Function (UMF) states that cosmic objects are in direct relation to each other and suggests that massive objects are much rarer than objects with lower masses. As a result, the following research aims to examine if the UMF theory is applicable to the field of organic chemistry, specifically to the yield prediction. The primary reaction conducted was completed in an aprotic environment. This reduction was performed on several different ketone …

Understanding The Healthcare Needs Of Lgbtq+ Adults In South Florida, Vir Patel, Emilee Tennen, Christina Bedley, Dhruv Edamadaka

Undergraduate Student Symposium

Adults over the age of 65 represent 18% of Broward County's population. Over 886,000 lesbian, gay, bisexual, transgender, or queer (LGBTQ+) individuals live in Florida, with 43,000 LGBTQ+ seniors residing in Miami-Dade, Broward, and Palm Beach Counties. Lifetime stigma, discrimination, and structural stressors impacting their social determinants of health (SDOH) engender negative long-term health outcomes, such as elevated rates of mental health and substance abuse issues, among LGBTQ+ adults. The purpose of this study is to assess the SDOH that affect LGBTQ+ adults in South Florida and their interests in community health events. 110 LGBTQ+ adults who attended either the …

Unraveling The Complexities Of Gulf War Illness: Insights From Symptom Clustering And Laboratory Analysis, Anushka Agrawal

Undergraduate Student Symposium

Gulf War Illness (GWI) is a chronic condition impacting a subset of veterans who served during the Gulf War of 1990–1991. Exposure to extreme stress, endocrine-disrupting chemical agents, and mild traumatic brain injuries (mTBI) has been implicated in the development of persistent and overlapping symptoms. Understanding the associations between symptoms and laboratory findings is critical for developing more effective therapeutic strategies.

In this study, observational analysis was conducted on a cohort of GWI veterans to explore potential biomarkers and symptom patterns. The dataset included self-reported health surveys (SF36, MFI-100), laboratory panels (cortisol stress tests, cytokine profiles, CD cells, lymphocytes, monocytes, …

Percent Cover Of Porifera Species On Red Mangrove Roots In Key Largo, Lindsay Scherer, Jayleen Spaulding, Charlotte Gifford, Marissa Langnickel

Undergraduate Student Symposium

Sponges (Porifera) and mangroves (Rhizophoraceae) have a mutualistic symbiotic relationship: the mangrove provides a stable habitat for the sponge and carbon needed for sponge growth, while the sponge provides inorganic nitrogen necessary for mangrove development. Understanding the relationship between these species is important because this relationship allows both to grow faster and thrive in their environment. This study used photographs of quadrats framing the target species to investigate the percent coverage of Porifera on mangrove (Rhizophora mangle) roots in John Pennekamp Coral Reef State Park in Key Largo, Florida. It was expected that there …

The Therapeutic Potential Of Telmisartan On Male And Female Mice Subjected To A High Fat Diet, Julianna Bonetti, Ariana Hernandez, Iliana Uribe, Victoria Pulido-Correa, Chana Vogel, Natalia Noto

Undergraduate Student Symposium

A high-fat diet gives rise to metabolic syndrome, a cluster of risk factors for developing obesity, type II diabetes, hypertension, and dyslipidemia resulting in cardiovascular disease. Overactivation of the brain renin-angiotensin system (b-RAS), mainly through the angiotensin II type 1 receptor (AT₁R), causes vasoconstriction and neuroinflammation, thereby increasing the likelihood of neurodegenerative disorders. Telmisartan, an angiotensin receptor blocker (ARB) that is selective for the AT₁R type, typically used to treat hypertension, can also reduce weight gain, while improving dyslipidemia and glucose metabolism in male mice fed a high-fat diet. However, whether telmisartan can reverse behavioral changes …

Growth And Survival Of Sexually Propagated Land-Reared Brain Corals During An Intermediate Offshore Nursery Phase, Emma Horton

Undergraduate Student Symposium

Florida’s Coral Reef has degraded from significant stony coral loss due to global and local stressors, including heat stress, disease, and coastal development, leading to reduced natural coral recruitment. Assisted sexual propagation in land-based nurseries can increase the number of genetically unique corals available for restoration efforts. A grow-out phase, in which land-reared corals are placed into an offshore nursery before outplanting on the reef, is often employed to allow corals time to grow and acclimate to the ocean environment. However, research on the performance of recruits within offshore nursery settings remains limited. Here we examine the growth and survival …

Volleyball Serve Analysis Using A Wearable Electroencephalograph (Eeg) Device In Collegiate Athletes, Taylor Stockman

Undergraduate Student Symposium

The volleyball serve is a crucial skill within the sport. Service errors drastically change the momentum of the game, and understanding how to reduce these errors could create positive outcomes for players. The study will utilize the electroencephalograph (EEG) device to analyze brain activity and record the four types of brain waves: alpha, beta, theta, and delta. The added component of the self-report survey will aid in exploring individual differences of athlete’s connection between brain function and volleyball serves. The purpose of this study is to assess collegiate volleyball players brain function during volleyball serves using a wearable EEG. Participants …

The Brain's Plasticity Past The Cortex: Investigating The Portrayal Of Glial Cells In Neuroplasticity And Disease Rehabilitation, Sofia Valladares

Undergraduate Student Symposium

Neuroplasticity, the brain’s capability to reorganize and create new neural connections, has consistently been assigned to neurons. Still, up-and-coming research highlights the important role of glial cells: astrocytes, microglia, and oligodendrocytes, in adjusting synaptic plasticity, carrying out neuronal survival, and clearing the way for network reconstruction. This research aims to investigate how glial cells influence and contribute to the brain’s flexible response and evaluate their possible future as therapeutic targets for conditions like traumatic brain injury and Alzheimer’s disease. Glial cells have proved to regulate neuronal survival, synaptic plasticity, and neuronal network reconstruction, proposing their potential as treatment objectives. By …

Media Representation And Public Perception Of Supreme Court Decisions, Estrella G. Romero Barriola

Undergraduate Student Symposium

This research project explores how inadequate, or oversimplified media portrayals can distort public understanding of the United States Supreme Court’s (the Court) intricate decisions. Through a close examination of notable cases like Bush v. Gore and Citizens United v. Federal Election Commission, in addition to other important rulings from the current 6-3 Court majority, the study investigates how partisan narratives and selective information shape public perception. It examines how media framing can obscure essential legal principles and foster misunderstandings about the judiciary’s function and neutrality. Furthermore, the project considers how the current Court, frequently viewed as favoring a particular ideological …

Modeling The Function Of Ryanodine Receptor 2 And Its Role In Catecholaminergic Polymorphic Ventricular Tachycardia (Cpvt) Heart Disease, Harani Athwale, Dillen-Preetesh Patel, Sai Puneeth Kothuru

Undergraduate Student Symposium

Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a potentially fatal condition linked to a mutation in the Ryanodine receptor (RyR2), the largest calcium ion channel known, which is crucial for heart function. The RyR2 protein is made of four similar subunits. Mutations in RyR2 can cause the channels to "leak," disrupting normal heart rhythms. In individuals with this mutation, the combination of caffeine intake and exercise can worsen these effects, leading to sudden cardiac arrest. With the RyR2 receptor located on the sarcoplasmic reticulum of cardiac muscle, the mutation prevents the receptor from fully closing, which hyperpolarizes the membrane and disrupts …