Digital Commons Network^™

Histone H3 Cysteine 110 Enhances Iron Metabolism And Modulates Replicative Life Span In Saccharomyces Cerevisiae, Chen Cheng, Brenna S Mccauley, Nedas Matulionis, Maria Vogelauer, Dimitrios Camacho, Heather R Christofk, Weiwei Dang, Nicholas A T Irwin, Siavash K Kurdistani

Center on Aging Staff Publications

The discovery of histone H3 copper reductase activity provides a novel metabolic framework for understanding the functions of core histone residues, which, unlike N-terminal residues, have remained largely unexplored. We previously demonstrated that histone H3 cysteine 110 (H3C110) contributes to cupric (Cu2+) ion binding and its reduction to the cuprous (Cu1+) form. However, this residue is absent in Saccharomyces cerevisiae, raising questions about its evolutionary and functional significance. Here, we report that H3C110 has been lost in many fungal lineages despite near-universal conservation across eukaryotes. Introduction of H3C110 into S. cerevisiae increased intracellular Cu1+ levels and ameliorated the iron …

Lipoprotein(A) And Risk Of Incident Atherosclerotic Cardiovascular Disease: Impact Of High-Sensitivity C-Reactive Protein And Risk Variability Among Human Clinical Subgroups, Ron C Hoogeveen, Margaret R Diffenderfer, Elise Lim, Ching-Ti Liu, Hiroaki Ikezaki, Weihua Guan, Michael Y Tsai, Christie M Ballantyne

Faculty, Staff and Students Publications

No abstract provided.

Strong Support Systems Foster Positive Self-Image In Patients With Scoliosis, Megan Glahn Castille, Susan Resendiz Ortega

Faculty, Staff and Students Publications

Purpose: Friend support and social support have been suggested to be beneficial for adolescents facing medical challenges; however, there is little research to identify who is providing emotional support for children and adolescents with scoliosis. Therefore, the purpose of this study was to investigate the sources of emotional support and to analyze a program designed to encourage social support, the Scolios-us Mentor Program (Mentor Program).

Methods: This study consisted of a cross-sectional survey. The survey included the SRS-22r, BSSQ-Brace, and questions about demographics, mental health, the Scolios-us Mentor Program, and general scoliosis experience. The survey was distributed via email to …

Tribute To Vanessa Merton, Paul Feiner

Pace Law Review

No abstract provided.

Vanessa Merton, In Her Own Words, Bennett L. Gershman

Pace Law Review

No abstract provided.

The Intersecting Association Of Speaking A Non-Dominant Language And Lower Healthcare Access On Self-Reported Depression Among U.S. Adults: A Cross Sectional Study Using Nhanes Data (2015-March 2020), Vincenzo J. Cornacchione, Corey Linver

OHSU-PSU School of Public Health Annual Conference

Objective: This analytic study examined the joint and independent associations between language preferences and healthcare access on moderate to severe depression among non-institutionalized adults living in the U.S., using data from the 2015 to March 2020 National Health and Nutrition Examination Survey (NHANES).

Methods: In this cross-sectional study design, we analyzed a nationally representative data set comprised of 11,051 participants. Multivariable logistic regression models were used to estimate the joint and independent associations between our dual exposures and moderate to severe depression, adjusting for key demographic variables based on our theoretical framework. We created categorical measures of preferred language (speaking …

Type 2 Diabetes Mellitus Among Haitian Americans, Balkys Bivins

General Submissions: Community and Population-based Materials

The primary objective of this study was to determine the prevalence of diabetes among Haitian Americans.

A convenience sample was used to collect baseline information, including Hemoglobin A1C (HbA1C) level, age, weight, height, basal metabolic index (BMI), and blood pressure measurements.

Upon approval from the Johns Hopkins Institutional Review Board, the researchers recruited more than 401 Haitian Americans.

An Exploration Of The Use Of Supplementary Materials By English Teachers In The Uae, Nour M. Hammo

Thesis/ Dissertation Defenses

This study explores the use of supplementary materials in English classrooms in the United Arab Emirates (UAE), exploring their types, how teachers integrate them, and the challenges they encounter when implementing them in their English language classrooms. Using materials in language teaching and learning is important and widely recognized. Understanding these materials and their use is crucial as educational institutions evolve in teaching English, particularly in multicultural-speaking countries like the UAE.
The study employed a qualitative case study approach, collecting data through triangulation, which comprised classroom observations, semi-structured interviews, and artifacts. Thematic analysis revealed patterns in the types of supplementary …

Sounds Of Battle And Battle Of Sounds: Belliphonic In Tolkien, Ali Mirzabayati

Journal of Tolkien Research

This paper explores the concept of the belliphonic—a term denoting the acoustic dimensions of warfare—within the context of J.R.R. Tolkien’s The Hobbit, focusing on the Battle of the Five Armies. While modern war studies have mainly centered on the mechanized soundscapes of twentieth-century conflict, this study engages with recent scholarly efforts to recover the sonic textures of medieval battle. Drawing on theories of wartime acoustics and examples from medieval literature, the paper examines how Tolkien, informed by his expertise in Old and Middle English texts and his lived experience in World War I, crafts a dynamic and psychologically …

You're Fake News. How Irish Political Journalists Manage In The Post-Truth Era, Niamh Thorton, John Hogan

Level 3

No abstract provided.

Human Error, Human Factors And Production Ergonomics. A Discussion From The Perspective Of Biopharmaceutical Manufacturing, Ann Ryan

Level 3

No abstract provided.

Cost-Effective Photogrammetry Techniques For Surveying, Recording And Documenting Stone Circles In County Wicklow, Maurice Murphy, Garrett Keenaghan, Alain Chenaux, Petra Kajacic

Level 3

No abstract provided.

Report On Optimal Methodologies For The Education Of Regulatory Assessors, Naomi Beard

Level 3

No abstract provided.

Preparation Of Nanoparticles And Study Of The Effect Of Some Of Their Physical Properties On Epoxy Polymer, Aya N. Abdullah, Niran F. Abeduljabbar

Al-Bahir

Nanoparticles were prepared by the laboratory thermal method from copper, magnesium, and zinc oxides. Different nanoparticles were added to epoxy at weight fractions of (0, 2, 4, 6, 8, 10) wt. %. The structural results from X-ray diffraction showed the appearance of epoxy in a random system, and when reinforced with nanopowders at higher addition ratios, we find the appearance of nanoparticles in a clear crystalline form, while the SEM results showed an increase in consistency and homogeneity with each increase in the proportions of nanoparticles, which appeared clearly during the EDX examination. The hardness of Shore type D was …

A Likely Story: The Differing Narratives Between The Anglican And Catholic Presentation Of The Reformation, Cecilia Broxon

Scholars Week

The story of the Anglican reformation is often simplified to the result of King Henry VIII's desire for a divorce; however, this paper argues that it was a complex and prolonged process marked by differing Anglican and Catholic narratives. By exploring primary sources, including letters and interviews, as well as secondary analyses, this paper discusses misconceptions surrounding the Reformation, such as its speed and primary motivations. It further examines the formation of early Anglican doctrine and the contrasting presentations of the Reformation, revealing instances of resistance, the destruction of Catholic art, and the mistreatment of churches, which are frequently downplayed …

A Spiritual Renewal For Italian Immigrants, Katie Douglas

2025 Awards for Excellence in Student Research and Creative Activity - Documents

When the Church had officially declared that an Italian who supported the unification of Italy could no longer be a Catholic in good standing, the question became this: to be a patriot, or to be a Catholic? This question of allegiance brought about anticlerical sentiments. When the wave of “new”-- mostly Eastern and Southern European– immigrants started coming to the United States starting in the 1880’s, they were met with pushback from many of the “old”-- particularly Irish and German– immigrants who held their clergy in high esteem. Many non-Catholic Americans simply used the label “new” vs “old” to describe …

Enoree Circuit Record Book, Enoree Circuit

Methodist Local Church Records

These handwritten minutes record the quarterly conference minutes of the Enoree Circuit in Union, Laurens, and Newberry Counties.

The Chanticleer, 2025-04-10, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

The Indiana Statesman, April 10, 2025, Indiana State University

Student Newspaper

Sycamore Remix; Party at the Fountain marks Spring Week midpoint

Forever Tree, Alyse A. Petersen

Healy Poetry Prize

No abstract provided.

Magical Differences As Textual Coding For Neuroqueerness, Killeen Reidy

2025 Awards for Excellence in Student Research and Creative Activity - Documents

In this paper I will be looking at Young Adult Fantasy texts in which their protagonist is magically differentiated from his world. I will argue that this protagonist, and those similar, can be analyzed as textually coded as neurodiverse due to his interactions with the other characters in his story and his society at large, as well as having experiences common to neurodiverse people in reality. Further, I will be arguing that the character can function within the definition of neuroqueer as defined by M. Remi Yergeau. These argumentations will be developed alongside each other with the idea of queer-coding …

Plaintiff-Appellant's Opening Brief, Amy V. Doukoure, John A. Meiser, Meredith H. Kessler, Domenic A. Canonico

Court Briefs

No. 24-2003
Marvin Owens v. Gary Schuette

On Appeal from the United States District Court for the Eastern District of Michigan Case No. 2:24-cv-10787

From the Summary of the Argument

This appeal requires the Court to correct an error below—derived from a recently abrogated error in this Court’s own precedent—that denies the full remedial protections enacted to safeguard religious exercise under RLUIPA. The only question is whether RLUIPA allows courts to award damages against counties and their officials. The only answer—especially following the Supreme Court’s unanimous interpretation of an identical provision in RFRA—is yes.

Assessing Oral Cancer Screenings Provided By Dental Hygienists, Nora N/A Basheer Megerdichian

Dental Hygiene ETDs

Oral cancer remains a significant public health concern, with a five-year survival rate of approximately 50% due to late-stage diagnoses. Dental hygienists play a crucial role in the early screening of oral cancer through routine intraoral and extraoral examinations. This study evaluates the effectiveness of oral cancer screenings conducted by dental hygienists in referring for further evaluation and their overall perception of the importance and frequencies of these examinations. A survey was distributed through the American Dental Hygienists’ Association (ADHA) to practicing dental hygienists across the United States, gathering data on screening frequency, referral patterns, perceived importance, and challenges faced …

Holocaust Resistance Activity: Storymaps And Museum Exhibition, Museum Of History And Holocaust Education

Museum of History and Holocaust Education Teacher's Guides

The Museum of History and Holocaust Education created this classroom activity and teacher guide to supplement our free educational videos and digital content about resistance to the Holocaust. To access the free resources needed for this activity, visit our StoryMaps webpage. We recommend that teachers preview the video content before showing it to students. The worksheets on pages 11–18 and copies of our Holocaust Resistance Image Gallery PDF can be printed out for classroom purposes.

Facilitating The Use Of Sbar By Nursing Staff For Handoff Communication, Amarillis L. Tompkins

Student Scholarly Projects

Practice Problem: Clear communication during shift handoffs is crucial to minimize errors and ensure patient safety in intensive care. The current SBAR framework used in the MICU is constrained by limited documentation space, which led to communication inefficiencies and heightened risks for patient care.

PICOT: The PICOT question that guided this project was: In the NFSG VA MICU, will staff nurses (P) using a revised SBAR communication tool with a checklist (I), compared to the current outdated SBAR tool without a checklist (C), improve the accuracy and completeness of patient handoff communication (O) over eight weeks (T)?

Evidence: The project …

Equipping East African Church Planters For Evangelism And Discipleship: An Evaluation Of Oral Bible Storying Training, Cynthia A. Easton

Doctor of Education (EdD)

This training evaluation study assessed the effectiveness of an oral Bible storying training on evangelism, discipleship, and the overall efficacy of a 5-day oral Bible storying training program conducted for 40 indigenous church planter leaders (CPLs) in Addis Ababa, Ethiopia. Using Kirkpatrick’s evaluation framework, the study assessed training effectiveness across all four evaluation levels: reaction, learning, behavior, and results. Through an observational learning assessment, a feedback session, and interviews conducted 6–8 weeks and 6 months after the training, the study documented the CPLs’ implementation of the method in their Christian ministries across Ethiopia, South Sudan, and Uganda. The findings revealed …

April 10, 2025, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Sustained Release Of Antifibrotic Nintedanib From Polymer Microparticles Reduces Dosing Frequency While Reducing Inflammation In Murine Idiopathic Pulmonary Fibrosis, Emmanuel Einyat Opolot, Filip Goshevski, Rahul Chaudhary, Horst A. Von Recum, Amar B. Desai

Faculty Scholarship

Purpose: Idiopathic pulmonary fibrosis (IPF) is a life-threatening, progressive lung disease with limited therapeutic options, often resulting in poor patient outcomes. Current treatments, such as Nintedanib (NTB) and Pirfenidone (PFD), require frequent administration, leading to adverse effects and low patient adherence. The purpose of this study was to investigate a sustained-release drug delivery system utilizing microparticles (MPs) composed of insoluble beta-cyclodextrin (β-CD) polymers to enhance the bioavailability and extend the release of NTB and PFD. Methods: A multidisciplinary approach, including in silico modeling, in vitro assays, and in vivo studies, was employed to assess the efficacy of β-CD-polymer MPs as …

Vista: April 10, 2025, University Of San Diego

USD Vista (1965-)

No abstract provided.

The Disrupted Symphony Of Speech: A Lesion Network Mapping Analysis Of Apraxia Of Speech, Payton Harris, Harrison Moore, Milija Grotenhuis, Jared Nielsen, Michael A. Ferguson

FHSS Mentored Research Conference

Apraxia of Speech (AOS) is a motor speech disorder that causes difficulty planning and coordinating the movements necessary for speech. This study uses lesion network mapping to identify the neural connections of AOS by tracing lesion data and analyzing their functional connectivity patterns. Our data indicates strong connectivity between the left primary motor cortex and right premotor cortex. The findings of the left primary motor cortex differ from most AOS research but still correlate with regional functions found in healthy populations. However, results related to the right motor cortex were much less expected, and suggested a larger, understudied role in …