Digital Commons Network^™

Atm-Dependent Dna Damage Response Constrains Cell Growth And Drives Clonal Hematopoiesis In Telomere Biology Disorders, Christopher M Sande, Stone Chen, Dana V Mitchell, Ping Lin, Diana M Abraham, Jessie Minxuan Cheng, Talia Gebhard, Rujul J Deolikar, Colby Freeman, Mary Zhou, Sushant Kumar, Michael Bowman, Robert L Bowman, Shannon Zheng, Bolormaa Munkhbileg, Qijun Chen, Natasha L Stanley, Kathy Guo, Ajibike Lapite, Ryan Hausler, Deanne M Taylor, James Corines, Jennifer Jd Morrissette, David B Lieberman, Guang Yang, Olga Shestova, Saar Gill, Jiayin Zheng, Kelcy Smith-Simmer, Lauren G Banaszak, Kyle N Shoger, Erica F Reinig, Madilynn Peterson, Peter Nicholas, Amanda J Walne, Inderjeet Dokal, Justin P Rosenheck, Karolyn A Oetjen, Daniel C Link, Andrew E Gelman, Christopher R Reilly, Ritika Dutta, R Coleman Lindsley, Karyn J Brundige, Suneet Agarwal, Alison A Bertuch, Jane E Churpek, Laneshia K Tague, F Brad Johnson, Timothy S Olson, Daria V Babushok

Faculty, Staff and Students Publications

Telomere biology disorders (TBDs) are genetic diseases caused by defective telomere maintenance. TBD patients often develop bone marrow failure and have an increased risk of myeloid neoplasms. To better understand the factors underlying hematopoietic outcomes in TBD, we comprehensively evaluated acquired genetic alterations in hematopoietic cells from 166 pediatric and adult TBD patients. Of these patients, 47.6% (28.8% of children, 56.1% of adults) had clonal hematopoiesis. Recurrent somatic alterations involved telomere maintenance genes (7.6%), spliceosome genes (10.4%, mainly U2AF1 p.S34), and chromosomal alterations (20.2%), including 1q gain (5.9%). Somatic variants affecting the DNA damage response (DDR) were identified in 21.5% …

Lineage Tracing And Single-Cell Rna Sequencing Reveal A Common Transcriptional State In Breast Cancer Tumor-Initiating Cells Characterized By Ifn/Stat1 Activity, Eric P Souto, Ping Gong, John D Landua, Ramakrishnan Rajaram Srinivasan, Abhinaya Ganesan, Lacey E Dobrolecki, Stephen C Purdy, Xingxin Pan, Michael Zeosky, Anna Chung, S Stephen Yi, Heide L Ford, Michael T Lewis

Faculty, Staff and Students Publications

A tumor cell subpopulation of tumor-initiating cells (TIC) or "cancer stem cells" is associated with therapeutic resistance, as well as both local and distant recurrences. Signal transducer and activator of transcription (STAT) activity is elevated in TICs in claudin-low models of human triple-negative breast cancer, which enables enrichment of TICs using a STAT-responsive reporter. Lineage tracing of TICs as they undergo cell state changes could enable a better understanding of the molecular phenotypes of TIC and uncover strategies to selectively target TICs. In this study, we developed a STAT-responsive lineage-tracing system and used it in conjunction with the original reporter …

A Screening Question To Assess Risk Of Using Antibiotics Without A Prescription: A Diagnostic Study, Ashley Collazo, Eva Amenta, Kiara Olmeda, Marissa Valentine-King, Lindsey Laytner, Azalia Mancera, Roger Zoorob, Michael K Paasche-Orlow, Richard L Street, Barbara W Trautner, Larissa Grigoryan

Faculty, Staff and Students Publications

Objectives: Non-prescription antibiotic use (using antibiotics without medical advice) is potentially unsafe and promotes antimicrobial resistance. We studied predictors of prior non-prescription use and whether screening for prior non-prescription antibiotic use predicted intention of future non-prescription antibiotic use.

Methods: The survey was performed from January 2020 - June 2021 in six public primary care clinics and two private emergency departments. Prior non-prescription users were respondents who reported taking oral antibiotics for symptoms without contacting a clinician. Intended use was defined by answering yes to the question, "would you use antibiotics without contacting a doctor/nurse/dentist/clinic." We examined predictors for prior non-prescription …

Nitrate Ameliorates Alcohol-Induced Cognitive Impairment Via Oral Microbiota, Xiangxue Li, Zhaojun Ni, Weixiong Shi, Kangqing Zhao, Yanjie Zhang, Lina Liu, Zhong Wang, Jie Chen, Zhoulong Yu, Xuejiao Gao, Ying Qin, Jingwen Zhao, Wenjuan Peng, Jie Shi, Thomas R Kosten, Lin Lu, Lei Su, Yanxue Xue, Hongqiang Sun

Faculty, Staff and Students Publications

Alcohol use is associated with cognitive impairment and dysregulated inflammation. Oral nitrate may benefit cognitive impairment in aging through altering the oral microbiota. Similarly, the beneficial effects of nitrate on alcohol-induced cognitive decline and the roles of the oral microbiota merit investigation. Here we found that nitrate supplementation effectively mitigated cognitive impairment induced by chronic alcohol exposure in mice, reducing both systemic and neuroinflammation. Furthermore, nitrate restored the dysbiosis of the oral microbiota caused by alcohol consumption. Notably, removing the oral microbiota led to a subsequent loss of the beneficial effects of nitrate. Oral microbiota from donor alcohol use disordered …

Introducing 'Society Work': The Professionalization And Localization Of Chinese Social Work In A New Era, Ke Cui, Timothy Sim, Chenxi Huang, Bowen Mcbeath

School of Social Work Faculty Publications and Presentations

This study focuses on current discussions around the newly-built Society Work Department in China. It argues that ‘society work’ helps to clarify the internationally recognized concept of ‘social work’ and this institutional reform promotes development of the social work profession and discipline, it also helps to decolonize social work in China.

Morphogenic, Molecular And Cellular Adaptations For Unidirectional Airflow In The Chicken Lung, Kamryn N Gerner-Mauro, Lisandra Vila Ellis, Guolun Wang, Richa Nayak, Peter Y Lwigale, Ross A Poché, Jichao Chen

Faculty, Staff and Students Publications

Unidirectional airflow in the avian lung enables gas exchange during both inhalation and exhalation. The underlying developmental process and how it deviates from that of the bidirectional mammalian lung are poorly understood. Sampling key developmental stages with multiscale 3D imaging and single-cell transcriptomics, we delineate morphogenic, molecular and cellular features that accommodate the unidirectional airflow in the chicken lung. Primary termini of hyper-elongated branches undergo proximal-short and distal-long fusions, forming parabronchi for air conduction. Through the parabronchial smooth muscle, neoform termini extend radially to form gas-exchanging alveoli. Supporting this radial alveologenesis, branch stalks halt their proximalization, defined by SOX9-SOX2 transition, …

Eyes On The Road: Disentagling Cyclist Mental Workload At Intersections, James Joseph Rawson

Civil Engineering ETDs

In North America, cyclists often share infrastructure with motor vehicles and encounter frequent conflicts with them at intersections. While past research assumes cyclists' experiences mirror those of drivers, most studies focus on roadway segments rather than intersections. This study addresses that gap by, for the first time we are aware of, examining cyclist perceptions at intersections using head and gaze movement data. Leveraging naturalistic data conducted in Albuquerque New Mexico, and statistical techniques, including t-test and repeated measures ANOVA, our findings suggest that – similar to drivers - cyclists do experience greater mental workload when performing turning movements than when …

Staff Update On Type 2 Diabetes Education, Toochukwu Endaline Mba

Walden Dissertations and Doctoral Studies

The current rise in Type 2 diabetes among middle-aged individuals poses significant risks of health complications such as kidney damage, heart disease, stroke, nerve damage, vision loss, and skin problems. Research has shown that proper education on the causes and risk factors of Type 2 diabetes would increase people’s knowledge about the medical problem, helping promote positive health outcomes. This project was a staff education program using didactic and interactive case studies.

Enhancing Emergency Department Communication: Structural Requirements And Outcomes Of Standardized Handover Processes, Bridgette A. Moss-Sherman

Walden Dissertations and Doctoral Studies

Effective communication during patient handovers is crucial for ensuring safe, quality care in the emergency departments (EDs) of small to medium-sized hospitals. The absence of standardized communication tools presents significant challenges, potentially leading to errors and hindering care coordination. This integrative review evaluates strategies for implementing standardized handover processes while examining their outcomes, underscoring the urgent need for enhanced communication practices. Grounded in the Donabedian quality conceptual framework, which encompasses structure, process, and outcomes as interconnected components of healthcare quality, the review identifies five key themes: (a) standardized communication protocols, advocating for the adoption of structured tools like SBAR and …

K-12 Administrators' And Teachers' Perceptions Of Legal Requirements For Providing Inclusive Education, Rebecca Kay Berger

Walden Dissertations and Doctoral Studies

At a large school system in the northwestern United States, students who received specially designed instruction services at the middle school study site were not always included with nondisabled peers in general education classes to the extent possible. The theoretical framework guiding this study was Vygotsky’s social constructivist paradigm, which says shared experiences shape people. Using a mixed methods, nonexperimental research design, data were collected using a concurrent, embedded strategy using a pre- and posttreatment online survey with 17 teacher-participants for the pretreatment survey and 11 participants for the posttreatment survey. The treatment in this study was a district-approved professional …

An Autoethnographic Account Of The Dimensions Of Learning To Teach, Angela Reyes-Carrasquillo, Diane Rodríguez

Journal of Multilingual Education Research

This is a review of the book Navigating Teacher Education in Complex and Uncertain Times by Carmen I. Mercado. The volume offers an autoethnographic narrative of an innovative learning and teaching process in teacher training including her role as a professor responding to the needs of the urban diverse students and their families served. It is an ethnographic contribution where Mercado’s life and work are intertwined. Through a rich autobiographical account, spanning 40 years, Mercado theorizes from her experiences as a teacher and teacher educator, offering powerful lessons to teachers and teachers’ educators alike.

Career Long Scholarly Contributions To Educating Teachers For Multilingual Classrooms And Exploring Multilingualism, Yidan Shao, Patricia M. Velasco

Journal of Multilingual Education Research

No abstract provided.

¿Y Ahora Qué? Interest Convergence And Hope Through Provision, Promotion, And Partnerships In Two-Way Dual Language Programs, Mitch Ingram, Charise Pimentel

Journal of Multilingual Education Research

As Two-Way Dual Language Programs continue in their nascent stages in the United States, some teachers, administrators, and researchers have reported issues of interest convergence. In this article, two researchers work alongside a bilingual pre-service teacher to highlight three such examples: the business of learning a language, Latin@ Spanish-speaking students used as resources, and the gentrification of bilingual education. Beyond the diagnosis of such dilemmas, we offer a preliminary framework and some promising tenets of hope to overcome any such asymmetries that can exist when interested families from different social locations agree to collaborate in the journey of dual language …

Sociocultural Predictors Of Children’S Papiamento And Dutch Reading Literacy In The Dutch Caribbean, Melissa Van Der Elst-Koeiman, Eliane Segers, Ronald Severing, Ludo Verhoeven

Journal of Multilingual Education Research

This study examined how Papiamento and Dutch attitude and home literacy environment of 168 children in fourth grade of the post-colonial Dutch Caribbean, predicted L1 and L2 reading literacy in sixth grade. Overall, children had higher scores for reading literacy in L1 Papiamento as compared with L2 Dutch. They showed more positive attitudes towards their mother tongue, regarding language use, reading, and media use. Furthermore, literacy activities at home were more frequent in L1 than in L2, although they reported having more books at home in L2 than in L1. Finally, L1 home literacy activities were negatively related to L1 …

Life Long Perspectives On The Multilingual Experience, Annie Shaba

Journal of Multilingual Education Research

Multilingualism Across the Life Span is a text that explores the subject of language diversity and multilingualism across an individual’s lifespan and their community. Edited by Unn Røyneland and Robert Blackwood, the book features co-authored chapters that look into the complexities of linguistic diversity, multilingualism as a lived reality, and the non-linear trajectories of language development. The book is divided into three parts: methodological and theoretical developments in bilingual acquisition, language practices and policies in the family, and bilingual aging, communication, and cognitive impairments. It offers insights from research conducted in various parts of the world and is relevant for …

Navigating Taiwan's Bilingual 2030 Policy: Unveiling Teachers' Glocalization Efforts And Agency, Ching-Ching Lin, Ming-Hsuan Wu

Journal of Multilingual Education Research

As a strategic initiative aimed to enhance English communication skills and bolster the global competitiveness of the general population, Taiwan’s Bilingual 2030 Policy takes place at the intersection of neoliberalism, globalization, and the global spread of the English language. The neoliberal framing of Taiwan’s language education policy has exerted powerful influences on teacher education, teacher hiring practices, curricular design, assessment, and other school practices. While the neoliberalist influences are prevalent among countries in the Global South, responses and resistance may take many forms embedded in specific sociocultural contexts. The reflection discussed here examines the challenges faced by teachers in Taiwan …

Jmer Volume 13

Journal of Multilingual Education Research

No abstract provided.

Bleu Pour Toujours (Blue Forever), Macha Petre

Vernacular: New Connections in Language, Literature, & Culture

Since this short story is written in French, the abstract below is available in both English and French.

Bleu pour toujours (« Blue Forever ») is a short story blending poetry and science fiction. In the near future, war, pollution, and human activity have devastated our world. The blue sky exists only in history books or old photographs. Amid this gray, monotonous despair, an unnamed, ageless, and genderless character escapes one evening and makes unsettling discoveries. Something is stirring. Upon waking, they find everyone has vanished, and the laws of the universe have been upended. In place of the sky …

Translation And Migration, Utopia And Dystopia: Representations Of The Labor Of Cultural Mediation In Fictional Eastern Europe And The Real Us-Mexico Border, James L. Richie Iv

Vernacular: New Connections in Language, Literature, & Culture

With the publication of Moira Inghilleri’s book, Translation and Migration (2017), the linguistic act of translation and the social phenomenon of migration have been linked in the world of interdisciplinary studies, yet this linkage may obscure the relevance of works in which only one phenomenon (translation or migration) is presented. A case study in which a work exploring migration can be contrasted with a work exploring the function of translation may reveal in one another the social forces that condition both practices. In Lucas Pope’s independently created video game Papers Please (2014), the player embodies a border patrol agent in …

Portrait Of A Fascist: Identity And Independence In Joseph Roth’S Das Spinnennetz (1923), Braden M. Ross

Vernacular: New Connections in Language, Literature, & Culture

Three days before Hitler’s Beer Hall Putsch, the last chapters of Joseph Roth’s Das Spinnennetz were published in the Viennese Arbeiter-Zeitung. Detailing the decent of World War I veteran Theodor Lohse into the nascent Nazi party, Roth’s novel could not have been more prescient—and yet, it remains the least well-known of his works. Das Spinnennetz is not only a work of great fiction, but an eerie cautionary tale more prophetic than Roth could have ever imagined. In this article, I examine the metaphor of the spider’s web and how ordinary people like Lohse futility navigate their search for individual meaning …

The Aesthetics Of Belonging And Longing For A Home In Toxi, Temitayo O. Babayeju

Vernacular: New Connections in Language, Literature, & Culture

Robert Stemmle's film "Toxi" explores the challenges faced by Afro-German children in 1950s West Germany as they search for a place to belong in a society where most people look different from them. This essay examines their search for a home while considering the lingering effects of fascist ideology. Through a close reading of the historical, economic, and sociocultural state of West Germany in the 1950s, I examine key scenes in the movie that address the search for a Home for Toxi, while also analyzing society's reaction to her as seen in the Film. Central to this analysis …

38. Protest 2025. United Faculty [Article]

LGBTQIA+ Archive Class Projects

Citation: NI Staff. (2025, April 9). United Faculty cements opposition to higher education bills in statement. Northern Iowan, 3.

The Impact Of Residential Segregation On The Health Of African Americans In The United States: A Systematic Review, Wuraola Awosan, Blessing Esohe Emokpae, Olanrewaju Olasehinde, Prince Osei Sarpong

Liberty University Research Week

Introduction/Background: Residential segregation is a persistent systemic issue in America that detrimentally impacts many facets of the lives of non-white Americans and immigrants, especially African Americans (AAs). Research has established that residential segregation is a vital health risk factor that affects the health and well-being of AAs through various mechanisms. This study aims to investigate the impact of residential segregation on the health and well-being of AAs. Methods: Using a systematic literature review approach, literature was searched in the Google Scholar and PubMed databases using predefined keywords joined with the Boolean operators "and" and "or." This literature search yielded 500 …

Psalms-Ccli Comparison Via Natural Language Processing, Tan Loc Nguyen, Christopher Jaus, Jay Hamilton, Joobong Bae, Nathanael Chu

Liberty University Research Week

Background: The Psalms is a body of worship given to us by God, so comparing the Psalms to the CCLI top 100 will reveal differences between Psalms and how we worship nowadays. We hypothesize that the Psalms, as a divinely inspired collection, show greater lexical diversity, emotional depth, and complexity in worship compared to the more streamlined expressions in CCLI music. Methods: We focused on the texts’ linguistic and theological characteristics. We leveraged Stanford’s CoreNLP AI to process 150 Psalms and the CCLI Top 100 songs across six analytical dimensions: Lexical Analysis, Sentiment Analysis, Named Entity Recognition (NER), Parts-of-Speech (POS) …

The Use Of Virtual Reality In Clinical Education To Improve Competency: A Literature Review, Stephanie Zoller

Liberty University Research Week

Background: Clinical simulations play a crucial role in nursing education, allowing for the development of important skills in a secure setting. With the use of virtual or augmented reality technology, students can perform tasks and be immersed in real-life scenarios. This gives students a chance to better develop skills, including communication and compassion along with hands-on skills. Despite the advancements, virtual reality remains significantly underused in nursing education. This technology has the potential to enhance nursing interventions within a controlled setting, ensuring the safety of both patients and students. Purpose: To examine the viability of using virtual reality curriculum to …

The Shorthorn: April 15, 1942

The Shorthorn Newspaper Collection: 1940s

No abstract provided.

The Shorthorn: April 14, 1942

The Shorthorn Newspaper Collection: 1940s

No abstract provided.

The Shorthorn: April 7, 1942

The Shorthorn Newspaper Collection: 1940s

No abstract provided.

The Shorthorn: March 31, 1942

The Shorthorn Newspaper Collection: 1940s

No abstract provided.

The Shorthorn: March 24, 1942

The Shorthorn Newspaper Collection: 1940s

No abstract provided.