Digital Commons Network^™

A Deep Learning Strategy To Identify Cell Types Across Species From High-Density Extracellular Recordings, Maxime Beau, David J Herzfeld, Francisco Naveros, Marie E Hemelt, Federico D'Agostino, Marlies Oostland, Alvaro Sánchez-López, Young Yoon Chung, Michael Maibach, Stephen Kyranakis, Hannah N Stabb, M Gabriela Martínez Lopera, Agoston Lajko, Marie Zedler, Shogo Ohmae, Nathan J Hall, Beverley A Clark, Dana Cohen, Stephen G Lisberger, Dimitar Kostadinov, Court Hull, Michael Häusser, Javier F Medina

Faculty, Staff and Students Publications

High-density probes allow electrophysiological recordings from many neurons simultaneously across entire brain circuits but fail to reveal cell type. Here, we develop a strategy to identify cell types from extracellular recordings in awake animals and reveal the computational roles of neurons with distinct functional, molecular, and anatomical properties. We combine optogenetics and pharmacology using the cerebellum as a testbed to generate a curated ground-truth library of electrophysiological properties for Purkinje cells, molecular layer interneurons, Golgi cells, and mossy fibers. We train a semi-supervised deep learning classifier that predicts cell types with greater than 95% accuracy based on the waveform, discharge …

A Dissertation On Belonging In Occupational Therapy Education With Students From Historically Minoritized Identities, Quinn P. Tyminski

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation provides a comprehensive exploration of the phenomenon of belonging specifically tailored to students with historically minoritized identities (HMIs) within the Washington University Program in Occupational Therapy (WUOT). Employing qualitative methodologies including scoping reviews, theoretical conceptualizations, focus groups, individual interviews, surveys, and participant video diaries, the study delves into the multifaceted nature of belonging within the context of occupational therapy (OT) education. The dissertation is organized into four key articles. The first two articles lay the theoretical foundation by examining the historical context of education as forced assimilation for minority groups and the nuanced use of professional behaviors to …

Development Of A Prototype Awsm-Pet System For Augmented Whole-Body Pet Imaging, Yunlai Chen

McKelvey School of Engineering Graduate Student Theses & Dissertations

Positron Emission Tomography (PET) is a critical imaging modality for medical diagnostics, yet its accuracy is often limited by spatial resolution and sensitivity constraints. This dissertation presents the development of Augmented Whole-body Scan via Magnifying PET (AWSM-PET), a novel technique integrating high-resolution auxiliary detectors with a clinical PET scanner to enhance sensitivity and resolution while remaining fully compatible with standard clinical protocols. The study encompasses hardware development, image reconstruction methods, and performance evaluation through imaging studies, including human trials. High-resolution outsert panel detectors were designed, mounted on a mobile cart, and integrated with a Biograph Vision PET/CT scanner. Firmware and …

Senescent Cancer-Associated Fibroblasts Mediate Immunosuppression And Promote Breast Cancer Progression, Jiayu Ye

Arts & Sciences Graduate Student Theses and Dissertations

Breast cancer is the most frequently diagnosed cancer among women worldwide, and aging is the largest risk factor for breast cancer development. The process of aging is typically accompanied by a progressive accumulation of senescent cells, which are characterized by a series of markers such as p16INKA4 (p16) positivity and a distinctive profile of secretory factors including mitogens, cytokines, and extracellular matrix (ECM) proteins that are collectively recognized as senescence-associated secretory phenotype (SASP). Numerous data so far have shown that senescent stromal cells play critical roles in modulating tumor microenvironment and progression. For example, senescent fibroblasts induced in vitro could …

Vocal And Articulatory Speech Control Deficits In Individuals With Post-Stroke Aphasia, Roozbeh Behroozmand, Zeinab Khoshhal Mollasaraei, Vahid Nejati, Ayoub Daliri, Julius Fridriksson Ph.D.

Faculty Publications

Individuals with post-stroke aphasia exhibit deficits in regulating vocal (i.e., laryngeal) pitch control during speech vowel production; however, it is not determined whether such deficits also exist when they control their supra-laryngeal speech articulators during word production. To address this question, 19 subjects with post-stroke aphasia and 20 controls were tested under an altered auditory feedback paradigm in which they received + 30% shifts in their vowel first-formant frequency during word production. In addition, 17 aphasia subjects and 19 controls from the same groups also completed steady vowel vocalizations while receiving randomized pitch shifts at ± 100 cents. Consistent with …

Historicizing The Prison In The History Of Capitalism, James Parisot

Sociology Faculty Publications

The goal of this paper is to rethink the timeline through which scholars have conceived of the history of capitalism and imprisonment. Scholars including Oliver C. Cox, Fernand Braudel, and Giovanni Arrighi, among others, have presented a story of capitalism centered around the Italian-city states, followed by the Netherlands, Britain, and the United States. Yet discussions on the origins of capitalism and imprisonment, eventually resulting in the invention of the penitentiary as an institution of reform, usually start around the sixteenth century. Incorporating insights from both of these angles, this paper shows the historical ways that different centers of capitalist …

The Geographic Identification Of Elevated Suicide Risk Model: Evaluating A Method For Examining Suicide-Related Behaviors At The Neighborhood Level In Harris County, Texas, Ryan M Hill, Sam C Cacace, Austin Starkey, Tyler Hendley, Jackson Bolner, Angela Cummings, Angie Hayes, Robert J Cramer

Faculty, Staff and Students Publications

Background: The 2024 National Strategy for Suicide Prevention has called for the development of community-based suicide prevention resources, and improved existing prevention efforts. In line with such efforts, Hill and colleagues developed the Geospatial Identification of Elevated Suicide Risk model that estimates the relative prevalence of adolescent suicide risk within specific geographical areas. The current study seeks to further evaluate and refine the model for use as a tool to evaluate risk and protective factors at the neighborhood level.

Method: Drawing from multiple sources, data was collected detailing adolescent suicidal ideation, suicide attempts, suicide fatalities, and census tract characteristics. Utilizing …

Dietary Patterns And Their Effects On C-Reactive Protein Regarding Female Reproductive Disorders, Mckenzie Moe

Theses and Dissertations

Objectives: Chronic inflammation, as indicated by elevated C-reactive protein (CRP), plays a critical role in women’s reproductive health disorders. CRP is one of the most common biomarkers of inflammation. Dietary components, lifestyle factors, and women’s reproductive health disorders are major components that influence the levels of CRP within the body. Other influential factors include injury, infection, and illness. The purpose of this review is to explore the findings of literature available on nutrition interventions for CRP levels in consideration of women's reproductive disorders.

Methods: This narrative review examines the works of 15 articles, including 10 cross-sectional and five longitudinal designs. …

The Role Of Almonds In Exercise Recovery And Athletic Performance, Kathryn M. Trochman

Theses and Dissertations

Objectives: During exercise, many trained athletes and physically active adults experience symptoms of exercise-induced muscle damage (EIMD). The effects of EIMD can cause limitations in athletic performance and increased duration of exercise recovery. Nutritional interventions have shown results in improving the duration of recovery. However, there are few studies completed on common food items. This review aims to examine the role of almonds in exercise recovery and athletic performance. Methods: A literature search was conducted utilizing Google Scholar, PubMed, CINAHL Ultimate, and reference hand searching. The search parameters included the dietary intervention of almonds for trained athletes and physically active …

Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention In Patients With Non-St-Segment Elevation Myocardial Infarction In The United States: Results From Big Data Analysis, Chayakrit Krittanawong, Song Peng Ang, Neil Sagar Maitra, Zhen Wang, Mahboob Alam, Hani Jneid, Samin Sharma

Faculty, Staff and Students Publications

Non-ST-segment elevation myocardial infarction (NSTEMI) can be managed by ischemia guide strategies or early invasive strategies. Here, we present the findings of an updated contemporary analysis regarding the use of intracoronary imaging (ICI)-guided PCI versus angiography-guided PCI and in-hospital mortality in patients with NSTEMI in the United States using the NIS database from 2016 to 2021. ICI use increased by nearly threefold between 2016 and 2021, without a significant difference in in-hospital mortality, though interestingly, mortality rates compared with angiography guidance were similar and relatively low. In this study, the use of ICI was associated with lower adjusted odds of …

A Nuclear Rna Degradation Code Is Recognized By Paxt For Eukaryotic Transcriptome Surveillance, Lindsey V Soles, Liang Liu, Xudong Zou, Yoseop Yoon, Shuangyu Li, Lusong Tian, Marielle Valdez, Angela M Yu, Hong Yin, Wei Li, Fangyuan Ding, Georg Seelig, Lei Li, Yongsheng Shi

Faculty, Staff and Students Publications

The RNA exosome plays critical roles in eukaryotic RNA degradation, but how it specifically recognizes its targets remains unclear. The poly(A) tail exosome targeting (PAXT) connection is a nuclear adaptor that recruits the exosome to polyadenylated RNAs, especially transcripts polyadenylated at intronic poly(A) sites. Here, we show that PAXT-mediated RNA degradation is induced by the combination of a 5' splice site (ss) and a poly(A) junction (PAJ) but not by either sequence alone. These sequences are bound by U1 small nuclear ribonucleoprotein particle (snRNP) and cleavage/polyadenylation factors, which, in turn, cooperatively recruit PAXT. As the 5' ss-PAJ combination is typically …

Spectator 2025-04-17, Editors Of The Spectator

The Spectator

No abstract provided.

Kenyon College - April 17, 2025

The Kenyon Collegian

No abstract provided.

Novel Therapeutics For Myeloid Malignancies, Tim Kong

Arts & Sciences Graduate Student Theses and Dissertations

Myeloid malignancies are a group of heterogenous and clonal disorders that include myeloproliferative neoplasms (MPNs) and acute myeloid leukemia (AML). These blood cancers are driven by characteristic oncogenes and propagated by pro-inflammatory niches; MPNs demonstrate hyperactive JAK-STAT signaling and upregulate cytokines including TNF, IL-6, and IL-8. Current therapeutics such as ruxolitinib targeting JAK2 providing symptomatic benefit to MPN patients but are not curative and do not prevent disease transformation to acute myeloid leukemia (AML). As such, greater understanding of the underlying disease biology is still required with means of uncover cancer dependencies. Here, we utilize a series of multi-omic approaches …

A Historic Review And Empirical Revitalization Of The Stages Of Concern Questionnaire, Kent Anderson Seidel

School Leadership Review

This paper examines one of three central diagnostic tools of the Concerns Based Adoption Model, the Stages of Concern Questionnaire (SoCQ). The SoCQ was developed with a focus on K12 education. It has been used widely since developed in 1973, in early childhood, higher education, medical, business, community, and military settings. The SoCQ captures data about beliefs and intentions of individuals regarding their engagement with a new program or practice.

In our search of publications utilizing the SoCQ, we have found studies conducted across the world, with approximately 400 based in the United States 100 conducted outside the US. In …

Dismantling Inequities In The Faculty Evaluation System, Mary Petron, William Blackwell, Abbie Strunc

School Leadership Review

Qualifying for merit is a competitive and contentious process in higher education. Many merit structures are based upon traditional faculty evaluation systems which do not reflect the changing nature of higher education and thus, yield inequitable results. This article presents the case of a large department at a mid-size regional university that revised the system for merit and faculty evaluation to recognize undergraduate contributions and more equitably score the scholarship, service, and teaching of faculty members in the department. The case describes the relevant literature, the university and departmental context, the process for designing the new evaluation system, and lessons …

A Deep Fake Dilemma: The Battle Over Keeping It Real, Tyler Gollin

DePaul Journal of Art, Technology & Intellectual Property Law

No abstract provided.

“Germany’S Noble Cause Must Prevail”: General August Von Mackensen On The Great War's Eastern Front, 1914-17, Christian Mumpower

Liberty University Research Week

English-language accounts and appraisals of the Western Front have long dominated the historiography of the Great War. This prevailing interpretation tends to cast a shadow over other, nonetheless critical sectors of fighting and diminish contributions made on these fronts by less well-known commanders and the men who served under them. While the Western Front boasts a rich catalog of scholarship, few popular accounts exist about those who carved out a legacy for themselves on the Eastern Front, a sector of the war that saw some of the most desperate fighting but has since been relegated to the footnotes of history. …

Scientific Authorial Voice: Incorporating Explicit Instruction In Undergraduate Chemistry Courses, Emma Becker

Liberty University Research Week

The effective development of undergraduate chemistry students for success in professional and academic careers involves emphases on content knowledge and on writing and authorial voice. Unfortunately, most undergraduate chemistry instruction wholly neglects writing and authorial voice instruction in favor of content knowledge instruction. This results in the development of chemistry students who know the content of their field but not how to communicate that knowledge or how to enter the chemistry discourse with their own research. This integrative review identified 71 pieces of scholarly literature and synthesized these sources to reconceptualize writing instruction in undergraduate chemistry and propose explicit instruction …

Clarity In Christ: Oscar Wilde’S Revelation Through Imagination, Humility, And Suffering In De Profundis, Leah Besser

Liberty University Research Week

In studying De Profundis, some scholars – Max Beerbohm, Molly Robinson Kelly, and Carol Schnitzer, among others – have either claimed Oscar Wilde’s encounter with Christ to be inauthentic or altogether failed to address Christ’s prominence in the letter. This study, however, excavates the text with a more spiritual eye. Moving from a direct address of Sir Alfred Douglas to an intense self-observation, and finally, to a focus on the person and deity of Christ, Wilde’s letter leads him to increasingly spiritual and authentic realizations. He threads three main characteristics of revelation – imagination, humility, and suffering – throughout the …

Exodus 20:13 & The American Civil War: The Etymological Importance Of ‘Kill’, Christina Banker

Liberty University Research Week

Translating the Bible from Hebrew into the living English language has allowed word choice in translations to impact historical events. The American Civil War serves as a case study where the word choice of biblical translation led to questions of faith and duty among Christians. The etymological debate during the Civil War over ‘kill’ in Exodus 20:13 directly affected Civil War-era Americans, causing documented crises of faith among soldiers. The King James Version was carried into war by Civil War soldiers with the Hebrew word ratsach, translated as kill instead of the more accurate English translation of murder, allowing for …

Continuity In Colonization: A Comparative Study Between Hampton And Jamestown, Virginia, Regarding Their Occupation And Its Impact, Chandler Lilley

Liberty University Research Week

It has been widely circulated that Jamestown, Virginia, is the oldest permanent continuous English settlement in the New World. Not all parts of that statement are true. Locals of a place no more than half an hour down the road would contest that claim, saying that the city of Hampton better fits the criteria. What do those qualifiers mean, and which settlement deserves the title? Based on an examination of primary and secondary sources, both settlements will be compared with the qualifiers oldest, permanent, continuous, and English. To be oldest, the founding of the current location of the settlement must …

Brewing Revolution: The Influence Of Cafés In Eighteenth-Century France, Ian Landry

Liberty University Research Week

The cafés of eighteenth-century France occupy a central role during this era. They were places that both the literate and illiterate flocked to in order to receive the latest news and debate about relevant current events and topics. The material disseminated from these places prompted discourse and ultimately shaped the public’s opinion. With this in mind, cafés deserve a more prominent role in the discussion on eighteenth-century French studies in general as well as the French Revolution specifically.

To Parent Or Not To Parent: How Far Do Parental Rights Extend?, Emilie Das

Liberty University Research Week

American citizens have rights under the United States Constitution. However, not all rights appear in the written text of the Constitution. These rights are called fundamental rights, and they receive protection from constitutional amendments. Parental rights constitute a fundamental right protected by the Substantive Due Process Clause of the Fourteenth Amendment. However, landmark cases discussing parental rights leave ambiguity as to how far this fundamental right extends. The circuit split between the Third and the Ninth Circuit Court of Appeals in Gruenke v. Seip and Fields v. Palmdale, respectively, demonstrates this ambiguity. Both decisions rely on Supreme Court precedent but …

The King’S Antiquary: John Leland Between Destruction And Preservation, Christopher Dykes

Liberty University Research Week

This study examines John Leland's complex role as a royal commissioner during the dissolution of the monasteries. As the "King's Antiquary," Leland found himself caught between seemingly contradictory missions: participating in dismantling monastic institutions while simultaneously working to preserve their scholarly and cultural heritage. The research explores how Leland, educated as a humanist and appointed with a royal commission to survey England's libraries, navigated these competing loyalties through his extensive library tours, meticulous transcriptions, and ambitious documentation projects, including the Collectanea and De Viris Illustribus. Particular attention is given to Leland's nationalist motivations, evidenced in his concern about foreign scholars …

Volume 12 Complete Issue, James W. Gallagher

The Geographical Bulletin

Volume 12 Complete Issue

An Epigraphic· Geography Or "Kilroy (Amongst Others) Was Here", George F. Carter

The Geographical Bulletin

Vigorous debate has raged virtually since Columbus' discovery of America over who the American Indians were, where they came from, how they got here, and what the source of their civilization was. Momentarily, consideration was given to their being a separate creation; not the descendants of the people of Genesis. The Pope settled that by stating firmly that the Indians were God's creatures just as surely as the Spanish and Portuguese were, and as such entitled to all the rights, duties, and privileges thereto appertaining as they say as they cap and gown you.

Multilingual Learner Toolkit, Bailey E. Pugh

Student Scholar Showcase

As classrooms become more diverse, educators must always be developing new approaches using strategies and resources to support multilingual learners. This presentation introduces a multilingual learner toolkit designed to help general education teachers create inclusive environments that meet students' linguistic and cultural needs. The toolkit features research-based strategies, instructional tools, and culturally responsive practices for supporting multilingual learners. The Multilingual Learner Toolkit is a resource designed to support educators in creating inclusive and successful learning environments for English Learners (ELs). This toolkit combines evidence-based strategies to enhance ELs' proficiency in speaking, reading, writing, and listening, while also addressing family engagement, …

The Squeeze, Sam Fletcher

Best Integrated Writing

In this short story, Sam Fletcher gives a glimpse into the world of Army Engineers. Through the lens of an outsider’s perspective, this story showcases the sometimes-tenuous relationship that accompanies working with ally forces during the global war on terror. While this story is a work of fiction, it mirrors the very real connections formed by exposure to danger and shared hardship. It is dedicated to the brave Engineers Fletcher served with who risked their lives to ensure the safety of others.

Middle Eastern Princess, Badia Abdellatif

Best Integrated Writing

This poem reflects the thoughts that cross Babia Abdellatif's mind and soul as she witness the injustices in the world. It brings together a collection of situations that often occupy her thoughts.