The Genomic Landscape And Prognostic Impact Of Kras, Stk11, And Smarca4 Mutations And Co-Mutations On Survival Outcomes In Non-Small Cell Lung Cancer, Peter Manolakos

All Dissertations

Non-small lung cancer (NSCLC) accounts for 85% of lung cancer cases, and Kirsten rat sarcoma viral oncogene homolog (KRAS), Serine/Threonine Kinase 11 (STK11), and SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4 (SMARCA4) mutations and co-mutations have been increasingly recognized for their potential prognostic significance. However, clear knowledge gaps remain regarding which treatments should be selected for patients who present clinically with KRAS/STK11 or KRAS/SMARCA4 co-mutations, as outlined in Chapter 1. Despite significant clinical development advancements in immunotherapy and targeted therapy, a deeper understanding of the influence of these genomic …

Exploring The Pedagogical Impact Of Software Development Live Streams: Informal Learning Opportunities For Software And Game Developers, Ella Kokinda

All Dissertations

Live streaming is an increasingly popular medium for throwing back the curtain on software development where streamers and viewers share their knowledge and experiences. Popular platforms like Twitch and YouTube enable developers to stream live coding sessions where people around the world can engage in real-time collaboration, feedback, knowledge sharing, and skill development. This work investigates the pedagogical implications and learning opportunities present in software and game development live streaming while focusing on the role of streaming as a learning environment and collaborative community. We begin by exploring summer camps as an informal learning opportunity for STEM education, highlighting the …

Countering Deficit Narratives Through A Blackcrit Lens By Examining Case Studies Of Black College Mathematics Students’ Classroom Experiences, Akhenaton Wilbourn

All Dissertations

This dissertation examines the lived experiences of 11 Black college mathematics students at their predominantly white institution (PWI) through the lens of Black Critical Theory (BlackCrit) to counter deficit narratives about the racial achievement gap (RAG) in mathematics education courses. Deficit narratives often attribute disparities between Black and white students’ mathematical performance to assumed deficiencies in Black students’ abilities rather than systemic inequities, historical marginalization, and ongoing anti-Blackness in educational settings (Cobb & Russell, 2015; Kress, 2021). Using multiple case studies, this study explores how anti-Blackness manifests in mathematics classrooms, how students navigate tensions between multiculturalism, neoliberal educational policies, and …

Preparing Preservice Teachers To Support Culturally And Linguistically Diverse Students Through The Implementation Of A High Leverage Practice, Mya Kelley

All Dissertations

The student population of United States (U.S.) schools is becoming more culturally and linguistically diverse. Similarly, students identifying as culturally and linguistically diverse students represent approximately 54% of students served under the Individuals with Disabilities Act (U.S. Department of Education, 2023). Despite increased ethnic diversity among students, the teacher workforce remains relatively homogenous, with most teachers identifying as White. Consequently, many new teachers feel ill-equipped to implement effective, evidence-based instructional practices to support culturally and linguistically diverse students. To prepare preservice teachers to meet culturally and linguistically diverse students' unique needs, teacher preparation programs must embed culturally relevant pedagogy and …

Defining, Defending, & Delusion: White Social Studies Teachers Grappling With Whiteness, Meghan E. Moore-Hubbard

All Dissertations

This study explores rural white social studies teachers’ understandings of their whiteness and racial identity. In this multiple-case study, four participants engaged with a reader designed to elicit discussion and reflection on whiteness. Over the course of one week, teachers read works by George Lipsitz, Reverend Thandeka, Charles W. Mills, and James Baldwin. Grounded in the work of these scholars and the theory of Critical Whiteness Studies, this study asked participants to reflect on, discuss, and design lesson plans to be implemented in their classrooms based on their understanding of whiteness. Data was gathered in the form of interviews, reader …

Effect Of Calculator Use On Algebra Progress Monitoring Slopes Among Students In Secondary Foundational Algebra Classes, Karon A. Burke

All Dissertations

Calculator usage has become commonplace in the secondary mathematics classroom, yet most progress monitoring studies using curriculum-based measurement tools have been completed without using calculators. The primary purpose of this study was to determine whether using a calculator made a statistically significant difference in the depiction of students’ growth rates among student participants who were low performing in mathematics and were enrolled in a foundational algebra course. This study spanned the Fall semester and included 46 ninth-grade participants from five classes who were all considered at risk, including students diagnosed with a disability and/or as multilingual learners. To validate the …

Bridging The Gap In Rural Education: Exploring Solutions For Enhanced College And Career Preparedness Among Secondary School Students, Patricia Moultrie-Goldsmith

All Dissertations

This study investigates how to improve college and career readiness (CCR) among high school students in rural areas. The study focuses on creating effective strategies that cater specifically to the unique needs of rural students. Using a blend of both quantitative and qualitative research methods, the study examines the effectiveness of specific interventions designed to raise students' readiness for college and careers.

The interventions tested include teaching methods and increased engagement with students. These were developed to tackle the common challenges that hinder educational outcomes in rural settings, such as limited access to advanced courses and extracurricular activities.

Findings from …

Borders And Burdens: Three Essays On Inter-Jurisdictional Tax Policy In America, Benjamin Jaros

All Dissertations

Individuals, firms, and governments make decisions about the tradeoffs of different tax policies at jurisdictional borders, such as those between states, nations, or local governments; those choices shape the burden of taxation. This dissertation examines the effects of three distinct changes in tax policy: for state corporate income tax apportionment, colonial tobacco tariffs, and tax abatements for data centers. Chapter 1 examines how changes to the corporate income tax base formula affect state tax revenues. Chapter 2 analyzes how colonial era export and import tariffs on tobacco impacted trade volumes, raised revenue, and the distribution of the tax burden between …

Shame, Identity And Reconciliation With Christ, Michele D. Corgiat

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to explore the impact of reconciliation with Christ on shame narratives and identity. Although shame and identity has been extensively researched, the added theological construct of reconciliation with Christ makes this research unique. This phenomenological study explored the impact of reconciliation with Christ on shame narratives and identity. Sixteen participants, ages 20 to 75 years, who professed to have reconciled with Christ through faith and repentance, were selected and interviewed. Each participant was interviewed three times over a four-week period using a transcendental phenomenological method. Data were collected and analyzed using reflexive thematic …

A Holistic Case Study On Leaders In The Division Of Enrollment Services’ Experiences Implementing Interdepartmental Partnerships In Higher Education, Christopher A. Almond

Doctoral Dissertations and Projects

The purpose of this holistic case study was to understand the experiences of higher education leaders in the division of enrollment services at a public research university who experienced departmental realignments or mergers because of performance-based funding initiatives. The study addresses the gap in the literature on the effect of change on interpersonal relationships in higher education. The theory guiding the study is Tierney’s theory on organizational behavior among college employees. The research methodology consisted of three phases. I conducted focus groups, individual interviews, and document analyses. The setting was a large research university in an urban city. There were …

Wesleyan-Style Bands : A Pilot Training Program In The Local Church, Bailey D. Barkley

ATS Dissertations

No abstract provided.

Rethinking Discipleship : Understanding Conflict As A Means Of Spiritual Growth, Donald S. Caulley

ATS Dissertations

No abstract provided.

The Effective Discipleship Methods Among College Students In Telangana Through Uesi Ministry, Dasari Rajesh

ATS Dissertations

No abstract provided.

The Best Practices Of Gospel-Based Ecumenical City Movements In The United States Of America, James Ross Middleton Jr.

ATS Dissertations

No abstract provided.

Transforming Believers To Disciples Of Christ : To Transform Twenty-First Century Believers Of The India Gospel Churches Into Disciples, Like The First-Century Disciples, Abraham Samuel Kallumpurathu

ATS Dissertations

No abstract provided.

Pastoral Succession : Identifying Biblical Models For Appointing The Next Generation Pastoral Leaders, Syam Jeevan Babu B.

ATS Dissertations

No abstract provided.

Effective And Sustainable Church Planting Strategies For Persians From A Muslim Background In Britain, Jonathan Aptin Samadi

ATS Dissertations

No abstract provided.

The Ai Input Class: Constitutional Urgency And Fair Licensing In Ai Copyright Class Actions, Xuan-Thao Nguyen, Elizabeth G. Porter

Articles

The humanities have long been under attack; now Big Tech is eating them for breakfast. Artificial Intelligence is undermining the cultural and constitutional values of human creativity; it is also threatening the livelihoods of the creative working class. Because neither Congress nor regulators can keep pace with AI’s pace of change, class actions have stepped into the breach. In the first wave of such litigation, authors and artists in courts on both coasts claim that AI companies violate intellectual property law when they “train” their systems on copyrighted works.

This Article analyzes what we call “input” AI claims—that is, proposed …

Computationally Guided Liquid Crystal-Based Competitive Binding Sensing Platform For Optical Detection Of Spike Protein, Homa Ghaiedi, Shubham Pandey, Sophia Ezendu, Tibor Szilvasi, Karthik Nayani

Chemical Engineering Faculty Publications and Presentations

A liquid crystal (LC)-based sensing platform for the rapid optical detection of SARS-CoV-2 ' s spike protein's receptor binding domain (RBD) domain is introduced. This platform utilizes a thermotropic LC, hosted on metal-cation decorated substrates, onto which the spike protein can competitively bind. Density functional theory (DFT) calculations guide the experiments that reveal a homeotropic-to-planar transition in the LCs upon exposure to SARS-CoV-2 spike-decorated yeast, providing a basis for sensitive virus detection. The sensor's reversibility/specificity is confirmed through antibody-induced orientation recovery of the LCs initial orientation. Strikingly, the sensor can detect approximate to 2000 copies of the spike protein per …

Utilization And Perception Of Individual Performance Assessments Among Instrumental Music Educators In Northeastern Pennsylvania, Thomas Bassett

Doctoral Dissertations and Projects

This qualitative grounded theory study aimed to develop a theory explaining how secondary instrumental music educators in Northeastern Pennsylvania select, implement, and perceive performance assessments. Teachers need actionable data to determine the next steps in the learning process. The study design included twelve semi-structured interviews of Pennsylvania-certified music educators and a content analysis of any scoring tools or rubrics that they provided. The analysis process included open, axial, and thematic coding with the development of the core category and theory. Despite some prior research into performance assessments in music education, the literature lacked research with explanatory power over teachers’ assessment …

Impact Of Education For Bedside Nurses In A Community Hospital To Increase Intent Or Utilization Of A Career Ladder Advancement Tool, Carrie E. White

Doctoral Dissertations and Projects

This scholarly project is centered on lack of engagement in a new career ladder program. This project includes the creation of career ladder education with an intent to help with understanding, support, and engagement of the nursing caregivers. Education was created to propel the work of the career ladder within a small rural hospital. The program is 12 weeks long and covers eligibility criteria, activity details, technology education, and one-on-one support for understanding of the career ladder program. The hopes for the educational program were to increase nursing satisfaction, with the intent to stay with the organization, and foster participation …

Examining The Role Of Insight, Social Support, And Barriers In Treatment Engagement In Individuals Diagnosed With Psychotic Disorders, Madeline M. Ward, Sarah Hope Lincoln

Student Scholarship

Treatment engagement for individuals with psychotic disorders is often low, and engagement is considered critical to improving outcomes and reducing chronicity of the illness. Lack of insight in psychosis has been associated with poor treatment engagement and is considered a core feature of psychotic disorders. One factor that may improve treatment engagement in psychosis, perhaps for individuals with low insight, is social support. Social support may improve treatment engagement by promoting insight or overriding the challenges of engagement related to insight, however, the relationships between insight, social support, and treatment engagement are not clear. The current study hypothesized that greater …

The Little Diagram That Could: Geometric Properties And Statistical Applications Of Persistence Diagrams In Topological Data Analysis, Eugene Kler

McKelvey School of Engineering Graduate Student Theses & Dissertations

Topological Data Analysis (TDA) is a collection of techniques for data analysis that leverages topological invariants of spaces formed from data points. These methods excel at extracting useful information from noisy or sparse data, making them attractive to many mathematicians, statisticians, and scientists. In this thesis, we explore TDA on three fronts: algebraic foundations, statistical applications, and metric properties. Throughout, the central object of study is the Persistence Diagram (PD), a summary of the changes in homology that occur as one builds simplicial complexes from the data by increasing a parameter.

Two Case Studies Of American Classical Music Patronage In The 1980s And 1990s, Skyler E. Dykes

Arts & Sciences Graduate Student Theses and Dissertations

This thesis examines how changes in the composition of classical music institutions’ funding bases in the 1980s and 1990s shaped their programming priorities and institutional behavior. Through two case studies—one focused on the Saint Louis Symphony Orchestra’s “In Unison” program and the other focused on Sybil Harrington’s philanthropic support of the Metropolitan Opera—it explores how individual and institutional funders used legal, financial, and symbolic mechanisms to exert influence over the music presented on symphonic and operatic stages. The first chapter argues that the Saint Louis Symphony’s community engagement efforts in the 1990s were shaped by the priorities of its public …

Correcting Sampling Bias With Privacy-Preserving Synthetic Data: Inference Stability Under The Da-Mi Framework, Hannah Jiang

Arts & Sciences Graduate Student Theses and Dissertations

With the rapid advancement into the Data Age, synthetic data has emerged as a promising avenue for sharing scientific information while protecting the original data. While existing research has primarily focused on generating synthetic data to accurately replicate the characteristics of observed data, we explore the potential of synthetic data to adjust for unrepresentative sampling. This study explores how sampling bias—specifically unbalanced subsets—impacts statistical inference, and whether synthetic data can help correct such bias. Using a Data Augmentation–Multiple Imputation (DA–MI) framework, we generate synthetic datasets from biased samples and evaluate parameter recovery under different correction strategies. Simulations under a Missing …

Analyzing Sleep Staging And Cognitive Transitions Using Fmrl Time Series Analysis, Qingwen Zeng

Arts & Sciences Graduate Student Theses and Dissertations

Understanding sleep stages and their underlying cognitive transitions is essential for advancing our knowledge of brain function. While sleep staging has traditionally relied on electroencephalogram (EEG), this study explores the feasibility of classifying sleep stages using only functional Magnetic Resonance Imaging (fMRI) data. We investigate the use of Hidden Markov Models (HMM) and Hierarchical Dirichlet Process Hidden Markov Models (HDP-HMM) to capture temporal brain-state dynamics from task-free fMRI recordings. A series of pipelines—including sliding window, two-stage majority filtering, and prototype-based mapping via the Hungarian algorithm—were implemented to align model-inferred states with EEG-defined sleep stages. Among the twelve tested pipelines, the …

Black Scare, Red Scare: The Fbi’S Covert War On Black Radical Activism, Christian E. Maddox

Arts & Sciences Graduate Student Theses and Dissertations

Black resistance movements have always existed to push the envelope and fight to establish political agency and freedom against the state and surrounding institutions that work to dispose of and disenfranchise Black communities across the U.S. The contentious relationship between the U.S. government and leftist movements is a rich and developed ground of scholarship analyzing how repression emerges and evolves across time as a tool against social movements fighting for change. This scholarship however misses how state agencies work to undermine and racially flatten Black radical movements through crafting official, racialized narratives and images that reshape what these movements represent. …

Associations Between Prenatal Inflammation And Dimensions Of Depressive Symptoms Across The Perinatal Period, Margaret M. Redic

Arts & Sciences Graduate Student Theses and Dissertations

Risk for depression increases during the perinatal period due to several biological and physiological changes, including fluctuations in inflammation. However, the timing and cytokine-specific effects on depressive symptoms during and after pregnancy are unclear. In this study, we examined relations between four cytokines (IL-6, IL-8, IL-10, and TNF-α) and depression at multiple time points throughout the perinatal period and investigated the role of dimensions of depressive symptoms in these relationships. We used longitudinal data of 314 mothers in the Early Life Adversity and Biological Embedding Study from the first trimester of pregnancy to the end of the first year postpartum. …

Do All Components Of Psychological Wellbeing Predict Cognitive Function?, Karysa Britton

Arts & Sciences Graduate Student Theses and Dissertations

Sense of purpose has been consistently associated with cognitive function. However, less is known about the associations between the other five components of wellbeing and cognitive outcomes. The current research aimed to establish which components of wellbeing are most strongly associated with cognitive function. Participants from the Midlife in the United States study (M_Age=56.18, SD=12.38) completed the Ryff Psychological Wellbeing Scales (1989) and the Brief Test of Adult Cognition. Multiple regression analyses were used to examine the cross-sectional and prospective associations between wellbeing and cognitive function. All six components of wellbeing were significantly and positively …

Confessions I Make To Myself: A Collection Of Poetry & Prose, Isabella R. Sotlar

English Undergraduate Honors Theses

Confessions I Make to Myself is a deeply personal collection of poetry and fiction, reflecting my journey through grief, self-reflection, and growth. The collection is particularly influenced by the passing of my grandfather, whose support for my musical and literary endeavors shaped much of my life. Many of the poems explore themes of loss, family, and relationships, while others reflect on introspective moments during my time abroad in Milan, Italy. The work also addresses personal struggles with anxiety, self-image, and a recent medical diagnosis, capturing the experience of being a young woman navigating the challenges of 2025.

The poetry in …