Digital Commons Network^™

Elementary School Counselors Perceived Barriers To Service Delivery Throughout The Covid-19 Pandemic, Kimberly L. Johnson

Walden Dissertations and Doctoral Studies

Elementary school counselors are essential to shaping the foundation of academic, social, and emotional development of children which was negatively impacted by the COVID-19 pandemic. ESCs were required to maintain the same level of engagement despite the pressing circumstances. No one has explored the lived experiences of ESCs as they faced extreme barriers and without this study, stakeholders would be ill-equipped to address their needs. The purpose of this descriptive phenomenological study was to explore ESCs perceived barriers to comprehensive service delivery during the COVID-19 pandemic. Husserl’s descriptive phenomenological research approaches were used, including only ESCs who worked throughout the …

How Do African American Women In Halfway Housing Perceive Their Experiences With Mental And Emotional Rehabilitation, Eiyana Middleton

Walden Dissertations and Doctoral Studies

After reviewing the literature, Black women living in halfway housing needed more culturally accommodative and responsive access to mental health care. Despite recent efforts to improve the access and quality of mental health services for Black Americans, some of the most common barriers that continued to exist include and were not limited to the following: stigma associated with mental illness and distrust of the health care system. The purpose of this hermeneutic phenomenological study was to understand Black women’s perceptions of their mental and emotional rehabilitation while living in halfway housing. The hermeneutic phenomenology theory was most appropriate as it …

Multilevel Factors Influencing Perceived Barriers To Adjuvant Endocrine Therapy Among Breast Cancer Patients At Medication Onset, Timothy Cocozza, Rita Smith, Ana Maria Lopez, Shari Rudoler, Rachel Slamon, Tingting Zhan, Jazmarie L. Vega, Minal Dhamankar, Aruna Padmanabhan, Suzanne M. Miller, Kuang-Yi Wen

Department of Medical Oncology Faculty Papers

Purpose: Adjuvant endocrine therapy (AET) significantly diminishes recurrence and mortality risks in hormone receptor-positive breast cancer (BCa) patients. Nonetheless, suboptimal adherence and premature discontinuation during the initial year of treatment undermine these positive outcomes. This study aims to understand the potential diverse factors associated with perceived barriers to AET compliance at the onset of medication. Methods: We assessed perceived barriers to AET using the ASK-20 instrument for BCa patients initiating AET within 3 months. Our survey also included demographic variables (e.g., musculoskeletal symptoms) and clinical traits (e.g., medication type). Stepwise regression analyses were employed to elucidate the links between multilevel …

Access To Justice For Deaf Defendants, Anna Zieba

Theses

Deaf individuals face systemic accessibility within the criminal justice system, which emphasizes the importance of the gaps in accommodations by the Americans with Disabilities Act (ADA). Inconsistent legal protection, limited access to interpreters, inadequate training for legal professionals, and a lack of technology resources obstruct effective communication for Deaf individuals. As a result, it prohibits achieving an effective and equitable legal outcome. This research paper will examine case studies, legal frameworks, and academic literature to highlight the critical need for reform, including mandatory Deaf culture training, standardized interpreting qualifications, and more resources to enable equitable access to justice.

Improving The Reproducibility Of Deep Learning Software: An Initial Investigation Through A Case Study Analysis, Nikita Ravi, Abhinav Goel, James C. Davis, George K. Thiruvathukal

Computer Science: Faculty Publications and Other Works

The field of deep learning has witnessed significant breakthroughs, spanning various applications, and fundamentally transforming current software capabilities. However, alongside these advancements, there have been increasing concerns about reproducing the results of these deep learning methods. This is significant because reproducibility is the foundation of reliability and validity in software development, particularly in the rapidly evolving domain of deep learning. The difficulty of reproducibility may arise due to several reasons, including having differences from the original execution environment, incompatible software libraries, proprietary data and source code, lack of transparency, and the stochastic nature in some software. A study conducted by …

Using Sustained Silent Reading In The Secondary English Language Arts Classroom To Increase Reading Engagement, Hannah S. Burwell

Dissertations

Reading scores have dropped precipitously over the past twenty years, and English Language Arts (ELA) teachers are looking for in-school academic interventions to mitigate this decline. This descriptive case study explored classroom experiences and student engagement with reading in a choice-based Sustained Silent Reading (SSR) program in a high school. The study examines student experiences through Expectancy-Value Theory (EVT). EVT suggests that a student’s engagement with reading will increase when they find the task valuable and believe success is achievable. The study explores how providing students with the independence to select their reading materials influences their experience in class and …

The Impact Of Flipped Classroom With Active Learning Model Of Instruction In Teaching Stoichiometry In Chemistry Among Black And Brown Students, Lawrence Femi Akintokun

Dissertations

Students pursuing professions in STEM sometimes encounter difficulties in General Chemistry, a semester-long foundational subject. A fundamental subject in this course is stoichiometry, which pertains to the mathematical connections between elements and compounds in chemical processes. This fundamental notion is essential for comprehending advanced chemistry subjects, although it may provide challenges for students because of its dependence on algorithms and prior knowledge. Research has predominantly concentrated on the conceptualization of stoichiometry through models endorsed by educators, rather than on student involvement. This project sought to investigate the interactions of Black and Brown students with essential stoichiometry ideas in General Chemistry …

"You Know The Rules": A Dramatic Experiment In Aromantic Literary Theory, April Chronowski

English

This paper proposes a new literary theory framework based on the zine "an aromantic manifesto" by yingchen and yingtong, as well as the work of Erving Goffman, using theater as a device to examine romantic relationships. Blending English and sociology, I focus each chapter on a different literary period and examine two plays each: early modern (Christopher Marlowe's Doctor Faustus and William Shakespeare's Much Ado About Nothing), modern (Edward Albee's Who's Afraid of Virginia Woolf? and Djuna Barnes' "To The Dogs"), and contemporary (Caryl Churchill's Cloud 9 and Margaret Edson's W;t). In tandem with analysis of formal elements---like …

Reduced Vns Settings Paradoxically Decreases Seizure Burden In A Patient Following Resolution Of Sleep Disordered Breathing, Austin Sponaugle, Rebecca Stainman, Christopher M. Carosella

Abington Jefferson Health Papers

Vagus nerve stimulation (VNS) can be a highly effective treatment option for patients with drug resistant epilepsy. Notably, VNS has demonstrated side effects including a unique form of sleep disordered breathing known as vagus nerve stimulator associated sleep disordered breathing (VaS). However, the ways in which VaS interacts with seizure frequency is unknown. We report a case of a 28-year-old woman who presented to our department with complaints of worsening sleep quality 3 years following VNS implantation. Upon polysomnographic (PSG) evaluation, it was discovered that she suffered from VaS. The patient’s VNS output current was then down titrated during a …

Seeking Healthcare In Many Different Places: Mental Health Strengths And Challenges Among Omani Female Adolescents, Zeyana Al Ismaili, Faye Gary, Cheryl M. Killion, Diana Lynn Morris, Sharon E. Milligan

Student Scholarship

Background: Adolescents undergo overwhelming physiological, psychological, social, and cognitive changes. The stress can be worse when they must meet cultural expectations. However, there is a paucity of literature regarding the cultural impact on adolescent mental health. Purpose: The phenomenological study aimed to describe Omani female adolescents' lived experiences with mental health issues within their cultural context and future well-being. Methods: The study employed semi-structured individual interview questions using a secured videoconferencing Zoom meeting. The participants were recruited using purposive sampling. The participants included single female Omani adolescents (aged: 18–24 years). A horizontalization analysis followed the transcription, translation, and backward translation …

Afflicted Epistemology: Knowledge, Illness, And New Media After “Truth”, Annika Nilsson

Arts & Sciences Graduate Student Theses and Dissertations

This study examines how people living with complex, medically underdetermined chronic illnesses make sense of their experiences through self-experimentation mediated by online forums and self-help groups in a cultural context characterized by significant controversy surrounding the status of science, expertise, and conventionally authoritative knowledge-producing institutions. Using virtual and conventional ethnography and critical media studies methods, it finds that the fragmentary and decentralized nature of the U.S. healthcare system intensified the interpretive challenges associated with complex chronic illnesses: information was extremely abundant, but deciphering its accuracy, reliability, and relevance proved difficult. In this context, participants relied on experiential knowledge to filter, …

The Role Of Il-33 In Itch, Anna M. Trier

Arts & Sciences Graduate Student Theses and Dissertations

Chronic itch is associated with a broad range of medical conditions, from inflammatory skin diseases to cancer and organ dysfunction, and has a lifetime prevalence of up to 20%. Despite being common and debilitating, the cellular and molecular mechanisms that drive chronic itch are just beginning to be elucidated. Thus, therapeutic options are limited. Recent studies have identified that various pro-inflammatory cytokines can directly activate sensory neurons. This has resulted in mounting interest in the therapeutic potential of inhibiting these neuro-immune interactions. IL-33 is constitutively expressed by epithelial cells, which allows for its rapid release upon tissue damage or stress. …

Lifespan Reference Curves For Harmonizing Multi-Site Regional Brain White Matter Metrics From Diffusion Mri, Alyssa H Zhu, Talia M Nir, Shayan Javid, Julio E Villalón-Reina, Amanda L Rodrigue, Lachlan T Strike, Greig I De Zubicaray, Katie L Mcmahon, Margaret J Wright, Sarah E Medland, John Blangero, David C Glahn, Peter Kochunov, Douglas E Williamson, Asta K Håberg, Paul M Thompson, Neda Jahanshad

Faculty, Staff and Student Publications

Age-related white matter (WM) microstructure maturation and decline occur throughout the human lifespan, complementing the process of gray matter development and degeneration. Here, we create normative lifespan reference curves for global and regional WM microstructure by harmonizing diffusion MRI (dMRI)-derived data from ten public datasets (N = 40,898 subjects; age: 3-95 years; 47.6% male). We tested three harmonization methods on regional diffusion tensor imaging (DTI) based fractional anisotropy (FA), a metric of WM microstructure, extracted using the ENIGMA-DTI pipeline. ComBat-GAM harmonization provided multi-study trajectories most consistent with known WM maturation peaks. Lifespan FA reference curves were validated with test-retest data …

Pausing Patterns Across Speech Tasks In Individuals Diagnosed With Broca's Aphasia, Kate Low

Theses and Dissertations

The purpose of this study was to investigate whether individuals with moderate Broca's aphasia exhibit different pause duration and frequency patterns compared to individuals without neurological disorders, as well as to explore how speech task type influences pause patterns. A total of 16 participants (eight male and eight female) previously diagnosed with moderate Broca's aphasia and apraxia were included in this study, along with 16 age- and gender-matched control participants. Speech recordings from the 16 participants were sourced from the AphasiaBank database. Speech samples from four different task types (i.e., interview, personal narrative, picture description, and story retell) were analyzed …

Identification Of Glaucoma Subtypes Using Unsupervised Machine Learning Methods, Asma Poursoroush

Electronic Theses and Dissertations Archive

Healthcare is currently in a transitional stage between demonstrating the potential of clustering algorithms in personalized medicine and their widespread adoption. With recent advancements in unsupervised data analysis, clustering methods have become increasingly important in disease subtyping. However, the design, development, optimization, and implementation of automated subtyping systems require further maturity before they can be fully integrated into healthcare systems. This dissertation investigates the application of clustering algorithms in creating automated subtyping systems and highlights the current challenges and limitations that must be addressed to facilitate clinical translation into personalized healthcare. Moreover, K-mean and density-based clustering were used to identify …

Incorporating African American Spirituals Into Solo Low Brass Repertoire, Shekinah Ball

Electronic Theses and Dissertations Archive

The African American spiritual is a sacred folk genre that was created by African American slaves in the 18th century. These songs are the foundation of past and present forms of American Popular Music. Throughout my studies as a classical musician (Euphonium and Trombone), I have not had the opportunity to learn about or play solo literature based on this unique form of American music within traditional music academia. I was first exposed to African American spirituals while studying at Florida A&M University. I joined the choir during the fall semesters, after resigning from the marching band. It was there, …

Back Matter, Harry Denny

The Writing Center Journal

Back Matter for Writing Center Journal 43.1.

A Self‐Monitoring Mobile App To Mitigate Risk Factors For Suicide And Self‐Harm In Junior (Resident) Doctors: A Review, Thematic Analysis And Concept Proposal, Rohit Shankar

Peninsula Medical School

Doctors, particularly those in training in the UK, are exposed to high levels of stress in their work, which can lead to burnout and mental health problems. According to the health and safety executive (HSE) Management UK standards, employers should recognise and minimise work-related stress for staff. Our review looks to examine if known risk factors for suicide and self-harm in doctors align with the themes of the HSE management standards on stress control i.e., demand, control, support, relationships, role, and change and if so, could this be used to build a self-awareness digital application. Four research databases were searched …

Living With Historic Architecture, Jenil A. Thornton

Bachelor of Architecture Theses - 5th Year

In recent decades, the awareness of history and heritage has permeated the state of our built-environment. In this line of thought, preserving, conserving, and restoring historic buildings have become a major approach in architecture. Further, with growing interests of a sustainable future, preservation, conservation, restoration, and adaptive reuse gives possible avenues for sustainable designs. Preservation is to create an environment to protect and prolong the buildings’ life, while Restoration is to preserve and reveal the aesthetic and historic value, the aura, of the space. Conservation is the combination of both preservation and restoration. Overall, they relate to interests in experiencing …

New Suburbanism Learning From Suburbia, Gregory A. Sweat Jr.

Bachelor of Architecture Theses - 5th Year

Why does current architecture not address suburban spaces? Suburban spaces are the bulk of what is seen in Atlanta Georgia; and are the most common lived space these spaces are known as Sprawl, this sprawl seen in Atlanta can be described as fragmented, contradictory, corporate, smooth, additive and ever expanding. Suburban spaces are also airy, convenient and it addresses the needs of our current societal needs. What happens when you embrace and intensify the junkspaces and non-places seen in suburbia? How do you live with the parking lot, the big box store and the strip mall? This thesis is about …

Intervention Techniques Targeting Echolalia: A Scoping Review, Adriana Dinello, Allison Gladfelter

CISLL Publications

Purpose:

Although echolalic speech is found in typical development, echolalia is most commonly associated with autism. As such, echolalia has frequently been the focus of various interventions aimed at autistic children. Recent research and the voices of autistic self-advocates indicate that echolalia serves as a meaningful form of communication or functionally supports self-regulation. As a result, the literature on how, or whether, to target echolalia in therapy is full of philosophically diverse approaches. To support evidence-based practice, the purpose of this scoping review was to inform speech-language clinicians about current research on interventions targeting echolalia and how disagreement on this …

Anti-Csf-1r Therapy With Combined Immuno- Chemotherapy Coordinate An Adaptive Immune Response To Eliminate Macrophage Enriched Triple Negative Breast Cancers, Diego A Pedroza, Xueying Yuan, Fengshuo Liu, Hilda L Chan, Christina Zhang, William Bowie, Alex J Smith, Sebastian J Calderon, Nadia Lieu, Weiguo Wu, Paul Porter, Poonam Sarkar, Na Zhao, Constanze V Oehler, Ondrej Peller, M Waleed Gaber, Qian Zhu, Charles M Perou, Xiang H-F Zhang, Jeffrey M Rosen

Faculty, Staff and Students Publications

Patients diagnosed with metastatic triple negative breast cancer (mTNBC) have limited treatment options, are more prone to develop resistance and are associated with high mortality. A cold tumor immune microenvironment (TIME) characterized by low T cells and high tumor associated macrophages (TAMs) in mTNBC is associated with the failure of standard-of-care chemotherapy and immune checkpoint blockade (ICB) treatment. We demonstrate that the combination of immunomodulatory metronomic Cyclophosphamide (CTX) coupled with anti-CSF-1R antibody targeted therapy (SNDX-ms6352) and anti-PD-1 (ICB), was highly effective against aggressive metastatic syngeneic

A Cluster Randomized Trial Of A Multicomponent Clinical Care Pathway (Mccp) To Improve Masld Diagnosis And Management In Primary Care: Study Protocol, Kyler M Godwin, Larissa Grigoryan, Aaron P Thrift, Hao Duong, Fasiha Kanwal, Traber Giardina, Himabindu Kadiyala, Andrew Zimolzak, Kavish R Patidar, Hashem B El-Serag

Faculty, Staff and Students Publications

Background: Metabolic dysfunction associated steatotic liver disease (MASLD) is the most common chronic liver disorder in the world. Most patients with MASLD are undiagnosed, untreated and unreferred. Treatment depends on diagnosis and accurate staging of fibrosis risk, and therefore screening at the primary care setting coupled with consistent, timely, evidence-based, widely accessible, and testable management processes is critical. Randomized controlled trials of methods for screening, diagnosis, severity stratification, and referral are lacking. We previously validated the MASLD clinical care pathway (MCCP), a multistep algorithmic process geared to support primary care settings in screening, diagnosis, risk stratification, and suggested referral and …

Weak Formulation For Solving Inverse Problems In Reproducing Kernel Hilbert Spaces (With Applications To Learning Dynamical Systems), Victor William Rielly

Dissertations and Theses

We combine numerical and machine learning techniques to present a general framework for solving inverse problems using vector valued reproducing kernel Hilbert spaces in a variational formulation. We present this framework in two papers. In the first paper, we present an original state-of-the-art method derived in the context of our general framework for learning dynamical systems. In the second paper, we generalize the method from our first paper to arrive at the framework for solving inverse problems. Then we apply our general framework to the task of learning dynamical systems. In both papers we consider numerous applications of our methods …

Experiences Of Support And Success For Students Of Color In The Midwifery Educational Setting, Laura Jenson

Dissertations and Theses

The United States spends more on healthcare than any other developed country, yet perinatal health outcomes are among the worst, particularly for Black and Indigenous pregnant women and people. Structural and societal racism has contributed greatly to these inequities, and while a diverse perinatal healthcare workforce has the potential to mitigate the impact of pervasive racism, professions such as nurse-midwifery have evolved over time to be predominately white. The purpose of this study is to explore how students of color experience support and apply personal strategies for success in the midwifery educational setting. A basic qualitative study was done using …

Effects Of Angptl3 Deficiency On The Regulation Of Hepatic Lipoprotein Production And Lipid Metabolism, Kendall Helene Burks

Arts & Sciences Graduate Student Theses and Dissertations

Cardiovascular disease is the leading cause of death worldwide. A major treatment goal is to lower plasma lipids, especially low-density lipoprotein cholesterol (LDL), the cardinal risk factor for coronary artery disease (CAD). Patients with familial hypercholesterolemia (FH) experience early-onset CAD due to extremely high LDL. Underdiagnosis and undertreatment of FH are exacerbated by limited therapeutic options. However, one strategy has successfully lowered LDL in FH patients: Inhibition of the hepatically secreted protein Angiopoietin-like protein 3 (ANGPTL3). Despite promising clinical data, the mechanism by which ANGPTL3 inhibition lowers LDL has not been fully described. Although ANGPTL3 has been shown to modulate …

Real-Time System Availability For Cyber-Physical Systems, Jinwen Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cyber-physical systems (CPSs), such as autonomous vehicles, are increasingly being deployed. The sensing, control, and actuation loop in CPSs must complete within strict timing constraints. Missing a real-time deadline can lead to catastrophic consequences, as CPSs continuously interact with the physical world. This highlights the importance of real-time system availability (i.e., timely execution) in CPS tasks, going beyond traditional security goals that primarily focus on confidentiality and integrity. From a security perspective, two factors affect real-time system availability. First, attackers with access to hardware resources in CPSs may disrupt the execution timing of real-time tasks. Second, the deployment of security …

Targeting Nonsense-Mediated Rna Decay In Splicing Factor Mutant Myeloid Malignancies, Claudia Cabrera

Arts & Sciences Graduate Student Theses and Dissertations

Approximately 50% of patients with myelodysplastic syndromes (MDS) (which frequently progresses to secondary acute myeloid leukemia [AML]), 60% of chronic myelomonocytic leukemia (CMML) and 20% of de novo AML harbor heterozygous somatic mutations in spliceosome genes. We and others have shown that mutations in spliceosome genes U2AF1, SF3B1, SRSF2 and ZRSR2 cause alterations in RNA splicing, leading to production of numerous aberrant RNAs. Interestingly, spliceosome mutant cells are more sensitive to genetic alterations or drugs that further perturb RNA splicing, compared to wild-type cells. The sensitivity of spliceosome mutant cells to further perturbations in RNA splicing raises the possibility that …

Functional Diversification Of Rice Ago1 Proteins, Rachel Elie Jouni

Arts & Sciences Graduate Student Theses and Dissertations

Global demand for food is outpacing gains from conventional plant breeding. Scientists have turned to molecular crop breeding techniques to increase crop output and mitigate global hunger; however, a common setback in this process is the pleiotropic effects of target genes. We need to develop strategies to specifically modulate desired traits without incurring undesired penalties. Natural evolution frequently balances such tradeoffs through extensive regulation, which we can leverage to produce more specific results. Reproductive development is an important target of breeding efforts due to its direct effect on yield. Rice, a major staple food crop for half the world’s population, …

Understanding Loss Of Beta-Cell Identity And Progression Of Diabetes In Polygenic Mouse Models Of T2dm, Sumitkumar Patel

Arts & Sciences Graduate Student Theses and Dissertations

Type 2 diabetes (T2DM) is caused by the complex interaction of multiple genes and environmental factors. T2DM is characterized by hyperglycemia, insulin resistance in peripheral tissues and impaired insulin secretion by the pancreas. While the decline in insulin production and secretion was previously attributed to apoptosis of insulin-producing β-cells, recent studies indicate that β cell apoptosis rates are relatively low in diabetes. In this dissertation, I investigated β-cell failure in diabetes using KK and KKAy mouse models of polygenic T2DM, which spontaneously develop hyperglycemia, glucose intolerance, glucosuria, impaired insulin secretion and insulin resistance. I found that β-cell failure in KK …