Digital Commons Network^™

The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons Of The Transcriptomic Landscapes Across Mouse Models, Ling Cai, Fangjiang Wu, Qinbo Zhou, Ying Gao, Bo Yao, Ralph J Deberardinis, George K Acquaah-Mensah, Vassilis Aidinis, Jennifer E Beane, Shyam Biswal, Ting Chen, Carla P Concepcion-Crisol, Barbara M Grüner, Deshui Jia, Robert A Jones, Jonathan M Kurie, Min Gyu Lee, Per Lindahl, Yonathan Lissanu, Corina Lorz, David Macpherson, Rosanna Martinelli, Pawel K Mazur, Sarah A Mazzilli, Shinji Mii, Herwig P Moll, Roger A Moorehead, Edward E Morrisey, Sheng Rong Ng, Matthew G Oser, Arun R Pandiri, Charles A Powell, Giorgio Ramadori, Mirentxu Santos, Eric L Snyder, Rocio Sotillo, Kang-Yi Su, Tetsuro Taki, Kekoa Taparra, Phuoc T Tran, Yifeng Xia, J Edward Van Veen, Monte M Winslow, Guanghua Xiao, Charles M Rudin, Trudy G Oliver, Yang Xie, John D Minna

Faculty, Staff and Student Publications

Lung cancer, the leading cause of cancer mortality, exhibits diverse histological subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung cancer, but data from these models are disparate, siloed, and difficult to compare in a centralized fashion. In this study, we established the Lung Cancer Autochthonous Model Gene Expression Database (LCAMGDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets covering 974 samples from genetically engineered mouse models (GEMMs), 368 samples from carcinogen-induced models, and 12 samples from a spontaneous model. Meticulous curation and collaboration with data depositors produced a robust and comprehensive database, …

G-Quadruplex Stabilizer Cx-5461 Effectively Combines With Radiotherapy To Target Α-Thalassemia/Mental Retardation X-Linked-Deficient Malignant Glioma, Sharvari Dharmaiah, Prit Benny Malgulwar, William E Johnson, Brandon A Chen, Vladislav Sharin, Benjamin T Whitfield, Christian Alvarez, Vasudev Tadimeti, Ahsan S Farooqi, Jason T Huse

Faculty, Staff and Student Publications

Background: Inactivation of α-thalassemia/mental retardation X-linked (ATRX) represents a defining molecular feature in large subsets of malignant glioma. ATRX deficiency gives rise to abnormal G-quadruplex (G4) DNA secondary structures, enhancing replication stress and genomic instability. Building on earlier work, we evaluated the extent to which pharmacological G4 stabilization selectively enhances DNA damage and cell death in ATRX-deficient preclinical glioma models.

Methods: Using the G4 stabilizer CX-5461, we treated patient-derived glioma stem cells (GSCs) in vitro and GSC flank and intracranial murine xenografts in vivo to evaluate efficacy as both a single agent and in combination with ionizing radiation (IR), the …

Enhancing Motor Function In Individuals With Lower Limb Amputation Through Peerbased Learning Of Balance And Fall Recovery Skills, Zoe Castle, Jer Ja Chuang, Jewel Granados, Danna Shaw

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose: Lower limb amputation (LLA) is a devastating condition that is becoming more prevalent in the United States. We examined the effects of peer-based action observation learning on the brain activation and the eyetracking pattern in individuals with LLA.

Methods: Fourteen individuals with LLA (51.9±12.6 years, 4 females, 9 with transfemoral amputations) were asked to learn a balance task through observing the movements demonstrated by individuals with LLA or persons with intact limbs. Electroencephalogram (EEG) signals, visual attention time, and peak saccade velocity were recorded when participants watched the demonstration videos. Power spectral density (PSD) was used to analyze the …

Gotta Be Fresh: Comedy Central’S Workaholics, Masculinity, And Paratextual Decay, Adamandrew Lenox

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis examines social media marketing materials for Workaholics, a sitcom aired on Comedy Central from 2011 to 2017, to study paratextual temporality/ephemerality, the “brand as friend” social media strategy, and how masculinity is articulated through paratexts. The project incorporates theories from the fields of social media and internet marketing studies, television content and industry studies, and promotional paratext studies. Research centered on 100 Workaholics X (formerly Twitter) posts, published from January 2012 to March 2017. Posts were collected using Google Chrome extension TwExportly. Qualitative textual and content analysis of these paratexts results in three categories of findings. First, I …

Secondary Educators’ Knowledge And Perceptions Of Their Own Self-Efficacy As It Relates To 504 Plan Accommodations For Students Diagnosed With Adhd, Anne Richardson

Seton Hall University Dissertations and Theses (ETDs)

This study investigated the role of Section 504 accommodations in meeting the needs of secondary students with attention-deficit/hyperactivity disorder (ADHD) in the United States. While legislation requires equitable education for students with disabilities, gaps remain in understanding how educators perceive their own abilities in implementing Section 504 plans for students with ADHD. The study used a qualitative research design to explore the academic and organizational challenges faced by secondary school students with ADHD, specifically examining the knowledge, perceptions, and self-efficacy of secondary educators regarding ADHD strategies and 504 plan accommodations. Semi-structured interviews were conducted via Zoom with 11 educators from …

Examining Validity And Reliability Evidence For The Multicultural Neuropsychological Scale (Muns) Party Subtest Scores, Madyson Hernandez

Masters Theses, 2020-current

Neuropsychological tests were developed primarily for Westernized, Educated, Industrialized, Rich, and Democratic (WEIRD) populations (Henrich, 2020; Fernández & Abe, 2018). According to the American Academy of Clinical Neuropsychology (AACN) Relevance 2050 Initiative project, approximately sixty percent of Americans will be deemed unsuitable for neuropsychological testing because test norms are primarily based on European Americans who speak English (AACN, 2015). To aid in effective cross-cultural neuropsychological assessment, The Multicultural Neuropsychological Scale (MUNS; Fernández et al., 2018) was developed to be easily translatable to various languages. The MUNS is a 40-minute neuropsychological test battery that examines cognitive abilities such as reading fluency, …

Characteristics Of Parent-Adolescent Relationships As Predictors Of Adolescents’ Future Emotion Regulation Abilities, Jaclyn H. Snyder

Masters Theses, 2020-current

Adolescence is a critical period for the development of emotion regulation skills and parents play a pivotal role in the shaping of such skills. Indeed, several characteristics of the parent-child relationship have been implicated in adolescents’ emotional development. Namely, parental acceptance of adolescents’ emotions, the quality of parent-child attachment, and the tactics parents utilize to resolve conflict with their child appear to be significant sources of influence. The current study aimed to examine each of these three factors as possible predictors of adolescents’ emotion regulation abilities later in life. Additionally, this study sought to understand the relative strength of these …

Sundown In Indiana: A Midwest Story Of Racism, Exclusion, And Memory, Kelsey A. Snyder

Masters Theses, 2020-current

Sundown towns were a prominent aspect of the northern life from the early 1900s till in some places till the 1970s but they have been lost to history. These towns have been silenced and erased not just from the history books but from public memory. Indiana is my home state and the three towns that will be discussed have all had an impact on my personal development especially in understanding race. Decatur and Huntington places I have called home, both have been classified as sundown towns. The third, Marion was the location of the one the last known lynchings in …

Power Impacts Target Goals And Responses To Racism, Urmi Chatterjee

Masters Theses, 2020-current

Racial microaggressions are harmful to people of color (POC) and inhibit their social functioning in the long term. Explicit forms of racism have been focused on in previous studies on interpersonal racial interactions. While studies have found the effect of confrontation on POC who experience subtle racism, other forms of responses to racism lack research. Are responses influenced by how powerful targets are? What happens when a powerful target experiences subtle racism? This study shows how power shapes the strategies people of color use to respond to subtle racism. We used a negotiation framework between three types of goals and …

Varied Versus Non-Varied Behavior-Specific Praise On Student On-Task Behavior, Jessica Boss

Masters Theses, 2020-current

The current study examined the effects of praise statements on students’ behavior by assessing how varied and non-varied behavior-specific praise statements effect student on-task behavior. An alternating treatment design was used to compare the treatment conditions of varied and non-varied BSP. During baseline, participants were not given feedback on their praise statements or their interactions. After baseline, participants were taught to a mastery criterion on varied and non-varied BSP conditions. In the experimental phase, the participants alternated between a condition providing non-varied BSP and a condition providing varied BSP. The results of this study showed that both varied and non-varied …

Item Response Predictors Of Disengagement On The Pisa, Juste M. Mehou

Masters Theses, 2020-current

International assessments, such as the Programme for International Student Assessment (PISA), are instrumental in understanding educational progress, assessing teaching effectiveness, and ensuring institutional accountability (OECD, 2023). Central to the validity of these assessments is the assumption that students will exert sufficient effort and perform to the best of their abilities (AERA, APA, & NCME, 2014). This assumption is essential to ensure that scores accurately reflect students' true abilities (Wise & Kong, 2005). However, there is a documented concern that students often exhibit low effort in low-stakes tests, such as the PISA, where individual results have no direct consequences (Wise & …

Empowering Paraprofessionals Through Behavioral Skills Training: Abc Data Recording, Addison Raso

Masters Theses, 2020-current

This study investigates the efficacy of the behavior skills training (BST) framework in enhancing data collection procedures for paraprofessionals. An add-in component analysis was used to evaluate the effectiveness of individual BST components. Three participants (i.e., Nathan, Molly, Bailey) were assessed across baseline, instruction, modeling, rehearsal, and feedback phases. Nathan showed little improvement, with low and variable performance across phases. Molly demonstrated gradual improvement, achieving high accuracy in the final phase with feedback. Bailey exhibited an initial decline, followed by a steady increase, reaching near-perfect accuracy in the final phase. Data analysis revealed an additive effect with feedback having the …

Adapting A Contingency Contract Across Environments For Interfering Behaviors And Coping Skills, Samantha N. Eckstein

Masters Theses, 2020-current

The purpose of this study was to examine the effects of taking an already successful contingency contract for an individual and adapting it to two separate environments to determine the effects on interfering behaviors and the utilization of coping skills. An AB design was utilized to allow for comparison of effects between conditions (i.e., control and treatment). The independent variable was the contingency contract(s) used across all settings and there were three dependent variable measures. These were the effects on interfering behaviors, skills demonstrated, and the utilization of coping skills. There is not enough evidence shown in the data to …

The Effects Of Goal Setting With Performance Feedback On A Teacher’S Use Of Praise And Reprimand Statements, Elisabeth Morris

Masters Theses, 2020-current

The purpose of this study was to further extend the literature on teacher praise-to-reprimand (PTR) ratios by systematically replicating a study by Criss et al. (2023). This study evaluated the effects of goal setting with performance feedback on a special education teacher’s use of BSP and reprimands. A changing criterion design was used to gradually increase the participant’s use of BSP in 15 min whole group reading sessions with up to four students in grades 4^th through 6^th. The results of the study demonstrate a functional relation with the intervention and participant’s use of BSP. Implications for …

Grief As Slip: (How Little I Show) An Exploration In Clay, When Words Are Not Enough, Michelle A. Smith

Masters Theses, 2020-current

Grief as Slip (how little I show) implies that even as we acknowledge our mortality and the fleeting nature of life, we still only reveal a fraction of our true selves or our deeper realities. The ceramic artwork in this exhibition carries and conveys a journey through the present and remembered emotions of the artists’ personal narrative. By juxtaposing the tactile nature of clay with the ethereal quality of human experience, Smith contemplates the profound interplay between material transformation and emotional resilience. The exhibition’s intent is to translate the essence of complex emotional states into abstracted forms so they can …

Development And Validation Of A Clinical Risk Model For Postoperative Outcome In Newly Diagnosed Glioblastoma: A Report Of The Rano Resect Group, Philipp Karschnia, Jacob S Young, Gilbert C Youssef, Antonio Dono, Levin Häni, Tommaso Sciortino, Francesco Bruno, Stephanie T Juenger, Nico Teske, Jorg Dietrich, Michael Weller, Michael A Vogelbaum, Martin Van Den Bent, Juergen Beck, Niklas Thon, Jasper K W Gerritsen, Shawn Hervey-Jumper, Daniel P Cahill, Susan M Chang, Roberta Rudà, Lorenzo Bello, Oliver Schnell, Yoshua Esquenazi, Maximilian I Ruge, Stefan J Grau, Raymond Y Huang, Patrick Y Wen, Mitchel S Berger, Annette M Molinaro, Joerg-Christian Tonn

Faculty, Staff and Student Publications

Background: Following surgery, patients with newly diagnosed glioblastoma frequently enter clinical trials. Nuanced risk assessment is warranted to reduce imbalances between study arms. Here, we aimed (I) to analyze the interactive effects of residual tumor with clinical and molecular factors on outcome and (II) to define a postoperative risk assessment tool.

Methods: The response assessment in neuro-oncology (RANO) resect group retrospectively compiled an international, seven-center training cohort of patients with newly diagnosed glioblastoma. The combined associations of residual tumor with molecular or clinical factors and survival were analyzed, and recursive partitioning analysis was performed for risk modeling. The resulting model …

Four Students Named Summer Eckley Scholars, Jeffery Woodard

Press Releases 2020-2029

No abstract provided.

A Theory-Based Examination Of Factors Influencing Caregivers’ Intentions To Disclose Sickle Cell Trait Status To Their Children, Christine A. Chaba

WUSM Theses and Dissertations – All Programs

Sickle cell trait (SCT), the heterozygous form of sickle cell disease, has significant implications for health and reproductive decision-making. Timely disclosure of SCT status to children by their caregivers is critical for promoting genetic awareness and supporting informed reproductive choices. However, many caregivers delay or avoid this conversation. This study examined the psychosocial and behavioral factors influencing caregivers’ intentions to disclose SCT status to their children, guided by the Theory of Planned Behavior and the Theory of Regret Regulation. A descriptive, cross-sectional study was conducted with 78 caregivers of Children with SCT, who completed an online survey. The study addressed …

Toward An Understanding Of Loneliness And Social Participation In Serious Mental Illness, Samantha B. Randolph

WUSM Theses and Dissertations – All Programs

Loneliness is an immense challenge facing the majority of Americans with Serious Mental Illness. Loneliness is linked to negative outcomes, including heart disease, reduced quality of life, and early mortality. Current loneliness interventions (e.g., social skills training, social support) do not effectively address all the complex factors that lead to loneliness in this population. More work is needed, therefore, to better understand how to optimally research and prevent loneliness among individuals with Serious Mental Illness, who experience unique barriers to social integration/participation and dwell in complex settings, such as permanent supportive housing. The presented dissertation aims to address current gaps …

Targeting The Beiging Of Muscle-Associated Adipose Tissue To Promote Muscle Regeneration, Jacob C. Parson

WUSM Theses and Dissertations – All Programs

The expansion of intra-muscular adipose tissue (IMAT) between myofibers and epi-muscular adipose tissue (EMAT) outside of the muscle boundary accompanies numerous pathologies including diabetes, muscular dystrophy, and aging. IMAT and EMAT are anatomically juxtaposed to myofibers. Some evidence supports that IMAT and EMAT impede muscle function. This is potentially due to paracrine factors that are secreted by IMAT/EMAT. Different adipose depots can be classified in numerous ways including where they are located anatomically as well as the factors in which they secrete. Unlike classical white fat, adipose depots classified as brown or beige, noted by the marker uncoupling protein-1 (UCP-1) …

Identifying Distinct Subgroups With Severe Pain In Sickle Cell Disease: A Cluster Analysis Of The Grndad Multi-Center Registry, Martha O. Kenney, Samuel Wilson, Morgan Rosser, Sophie Lanzkron, Julie Kanter, Susan Padrino, Payal Desai, Deepa Manwani, Alice Cohen, Stephanie Guarino, Ward Hagar, Joshua Field, Jane Little

Department of Medicine Faculty Papers

Sickle cell disease (SCD) affects millions of individuals worldwide, and is characterized by both acute, episodic pain and chronic, persistent pain. Despite the significant burden of the disease, clinicians continue to face significant challenges in treating SCD pain due to variability in pain experiences. The objectives of this study were (1) to identify distinct pain subgroups based on demographic and biopsychosocial characteristics and (2) to evaluate the relationship between the subgroups and pain impact - a SCD-disease specific measure of pain interference. To achieve these objectives, we performed a hierarchical cluster analysis on a cross-sectional sample of adults with SCD …

Dose Planning And Radiation Optimization For Thoracic Conventional, Twice Daily, And Stereotactic Radiation Therapy: A Delphi Consensus From A National Survey Of Practitioners, Hina Saeed

All Publications

Purpose: We sent surveys to a large number of radiation oncologists with active thoracic cancer practices and applied the Delphi method over 3 rounds to generate consensus dose-volume histogram metrics. We used these results to create consensus-based organs-at-risk dose constraints and target goal templates for practical implementation.

Methods and materials: In this institutional review board-approved study, data were collected using REDCap electronic data capture on a secure server. Radiation oncologists identified from the Accreditation Council for Graduate Medical Education-accredited departments' websites were asked to confirm their self-identification as thoracic radiation oncologists and nominate other respondents. All invitees were asked to …

Quick And Easy Method For The Determination Of Cocaine And Six Metabolites In Postmortem Hair, Samantha C. Mulkeen

Student Theses

Hair testing is increasing in popularity in toxicology because of its long window of detection and ease of collection and sample storage. However, it has its limitations largely due to external contamination of drugs. In particular, cocaine (COC) is a common offender of this as it has several routes of consumption. Analyzing metabolites of COC may be the key to distinguishing between consumption and external contamination. The aim of the present study was to develop a quick, easy, and sensitive method for the detection and quantification of COC, benzoylecgonine (BE), norcocaine (NCOC), cocaethylene (CE), anhydroecgonine methyl ester (AEME), meta-hydroxy-cocaine (m-OH-COC), …

Safety And Efficacy Of A Mesenchymal Stem Cell Secretome Therapy (Kpi-012) For Persistent Corneal Epithelial Defects: A Phase 1b Trial, Valeria Sánchez Huerta, Hugo Quiroz-Mercado, Enrique O Graue-Hernández, Alejandro Navas, Spencer Alford, Darius Kharabi, Stephen Pflugfelder

Faculty, Staff and Students Publications

Background: Persistent corneal epithelial defect (PCED) is a condition often refractory to conventional treatments. KPI-012 is a topical mesenchymal stem cell secretome therapy under investigation for PCED management.

Objective: To assess the safety, tolerability, and corneal wound healing efficacy of KPI-012 in a phase 1b, proof-of-concept, open-label, single-arm clinical trial.

Methods: The safety profile and tolerability of topical self-administered KPI-012 therapy (twice daily, 1-week duration) were first evaluated in an initial safety cohort of participants with pre-existing permanent vision loss and no active corneal disease (n = 3). The safety profile and efficacy of KPI-012 were then assessed in participants …

Exploring Arabic, Russian, And Spanish Native Language Teachers’ Perceptions Of The Flipped Classroom Model Through The Lens Of The Technology Acceptance Model (Tam2), David I. Daoud

Doctoral Dissertations

The flipped classroom has become increasingly popular across various educational settings over the last two decades. In the flipped classroom model (FCM), the teacher spends less time on traditional in-classroom activities like lecturing and giving tests, which are instead assigned as homework, and more time on hands-on learning. Although research has shown the FCM is effective in a variety of learning settings, little is known about native language teachers' perceptions of the FCM. This study explored the perceptions of 41 native Arabic, Russian, and Spanish foreign language instructors regarding the FCM at a college-level language institution. The study aimed to …

Effect Of Coarse Aggregate On The Stability And Mechanical Performance Of Ultra-High Performance Concrete (Uhpc), Rui Zhong, Mingyan Pan, Hongyu Wu, Zhao Cheng, Jianzhong Liu, Jingquan Wang, Yiming Yao, Hongyan Ma

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The effect of coarse aggregate (CA) on the stability and mechanical performance of ultra-high-performance concrete (UHPC) was investigated. To assess UHPC stability, a unique approach was developed that utilizes specially fabricated large specimens with a depth of 400 mm. It overcomes the drawback of limited CA migration distance using small specimens, which may not replicate conditions relevant to structural applications. The spatial distributions of various constituents along the vertical casting direction were quantified through image processing technology. Results showed an approximately 12 % reduction in CA content in the top layer, while the bottom layer exhibited 12 % more CA …

Equal Pay, Unequal Opinions: Navigating The Ongoing Circuit Split On Prior Pay As An Affirmative Defense Under The Equal Pay Act, Emily G. Young

University of Cincinnati Law Review

No abstract provided.

.Com Or .Gov: Should The First Amendment Care? A Proposed Alternative To Moody V. Netchoice, Llc's Editorial Discretion Rule, Jt Degrinney

University of Cincinnati Law Review

No abstract provided.

A View From Inside: The Federal Government's Pivotal Role In Securing And Advancing Access To Justice, Kalpana Kotagal

University of Cincinnati Law Review

No abstract provided.

Educational Broadcasting

Communication Research Trends

Pioneers of new communication technologies such as Edison and Marconi hoped that one of the major uses of their inventions would be to bring education to the masses. Lord Reith, the founder of the BBC public service concept of broadcasting, emphasized education in his famous triad, summarizing the aims of the BBC: 'to educate, to inform and to entertain'. The biggest markets and returns on capital investment were to be found in providing entertainment, however, and the less regulated broadcasters moved steadily in that direction. Today, broadcasting is firmly fixed in the minds of the public as primarily a means …