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Articles 46231 - 46260 of 1439434
Full-Text Articles in Entire DC Network
Establishing The Feasibility Of Sustained Sinusoidal Cervical Vestibular Evoked Myogenic Potentials In Young Adults, Ashton Fowlkes
Establishing The Feasibility Of Sustained Sinusoidal Cervical Vestibular Evoked Myogenic Potentials In Young Adults, Ashton Fowlkes
Dissertations, 2020-current
Cervical vestibular evoked myogenic potentials (cVEMPs) are used in clinics and research to assess the function of primarily the saccule. cVEMPs are typically stimulated with transient clicks or tone bursts through air conduction and are recorded from the sternocleidomastoid (SCM) muscle. The SCM is contracted by turning the head either left or right. In this study, we used sustained sinusoidal bone conducted stimuli. Using this new stimulus method allowed us to look at the possibility of a sustained cVEMP response, compared to the typically recorded transient response, as well as analyze the amplitude and signal-to-noise ratio (SNR) of the responses. …
The Dynamics Of Us-Bangladesh Relations: Before, During And After The 1971 War Of Liberation, 1947-1975., Mdaminul Islam
The Dynamics Of Us-Bangladesh Relations: Before, During And After The 1971 War Of Liberation, 1947-1975., Mdaminul Islam
Masters Theses, 2020-current
This thesis traces the dynamics relations between Bangladesh and the United States before, during and after the Liberation War of Bangladesh in 1971. The thesis argues that during the Cold War era the US wanted to build good relations with Pakistan to curb communism in the Middle East and the South Asia. As a result, during the Liberation War of Bangladesh in 1971, the Nixon administration did not support Bangladesh’s independence, even though US diplomats and other officials reported the ongoing genocide. Despite this fraught history and Bangladesh’s pro-Indian, pro-Soviet leanings, relations formed between independent Bangladesh and the United States …
From Essential To Expendable – Montagnards, Kurds, And U.S. Army Special Forces In Vietnam And Northern Iraq, Jake Brooks
From Essential To Expendable – Montagnards, Kurds, And U.S. Army Special Forces In Vietnam And Northern Iraq, Jake Brooks
Masters Theses, 2020-current
In the Vietnam and Iraqi conflicts, the U.S. Army Special Forces teamed up with indigenous ethnic monitories to bring the fight to all corners of the battle space, and to take advantage of their immense local knowledge and strategic locations. The Montagnards of Central Indochina and the Kurds in Northern Iraq allied with the Special Forces for a number of reasons: protection from their ruling governments, recognition for their movements for autonomy, increased access to better medicine and equipment, and the opportunity to strike back at their historical enemies. The Montagnards and Kurds taught the Green Berets how to better …
Confronting The Postcolonial Condition: A Study On The Blesser-Blessee Phenomenon In South Africa, Thandwa Maphalala
Confronting The Postcolonial Condition: A Study On The Blesser-Blessee Phenomenon In South Africa, Thandwa Maphalala
Masters Theses, 2020-current
Age-disparate relationships are causing a public health threat in South Africa and the region at large. However, these relationships and their effects are not unique to South Africa. There has been substantial research conducted to explore the social, cultural or economic meaning of this relationship type, its causes and effects in sub-Saharan Africa or in the interest of individual countries in the region. However, South Africa presents a special case for further study because the older men that adolescent girls and young women (AGYW) date and have sex with are commonly referred to as blessers.
The purpose of this …
Enhancing Theory-Driven Design And Evaluation Of Patient-Facing Technologies, Yang Gong, Yuheng Shi, Eric Yang, Katie Gahn, Heidi Mason, Yun Jiang
Enhancing Theory-Driven Design And Evaluation Of Patient-Facing Technologies, Yang Gong, Yuheng Shi, Eric Yang, Katie Gahn, Heidi Mason, Yun Jiang
Faculty, Staff and Student Publications
Patient-facing technologies (PFTs) are essential tools for patient-centered outcome research. The current designs of PFTs need solid theoretical support and face challenges with maintenance and sustainability. This paper identifies PFT features and theoretical frameworks that support patient engagement in cancer care. Six prevailing PFT features - feedback & alert, a summary of entries, education materials, aggregated review, dedicated staff, and reminders - were identified in the primary literature, and five theoretical frameworks were adopted to guide the design and evaluation of 20 PFTs. Further research into user-centered design, personalization, and social context in PFT development is recommended to connect system …
Developing A Dashboard To Facilitate Exploration Of Maude Studies, Eric Yang, Yuheng Shi, Yang Gong
Developing A Dashboard To Facilitate Exploration Of Maude Studies, Eric Yang, Yuheng Shi, Yang Gong
Faculty, Staff and Student Publications
The MAUDE database is increasingly used for research. However, the MAUDE publications are scattered in literature databases with fragmented topics, hindering researchers' exploration and identification. To address this issue and enhance the visibility of MAUDE topics in literature, we followed the Gestalt data visualization principles, utilizing the PubMed API and Google Looker Studio to extract, organize, and visualize literature pertinent to MAUDE. The 5-section dashboard exhibits publication trends, cross-filtered publications and authors, geographical distribution of authors and publishers, article scorecards, and donut graphs representing percentages concerning affiliations, journals, publication types, and MeSH terms. This effort created an intuitive, user-friendly dashboard …
From Starfleet To Space Law: Science Fiction And The Future Of Colonization Law, Abigail Coffey
From Starfleet To Space Law: Science Fiction And The Future Of Colonization Law, Abigail Coffey
Seattle Journal of Technology, Environmental, & Innovation Law
As humanity approaches the threshold of space colonization, legal scholars and policymakers are faced with unprecedented challenges in crafting frameworks that govern off-Earth settlements. This article explores how science fiction—a genre long preoccupied with the social, legal, and ethical dimensions of space habitation—can serve as a vital resource for shaping contemporary space law. Drawing on narratives from the minds of George Lucas, Robert Heinlein, Frank Herbert, and more, this article examines how science fiction anticipates legal dilemmas surrounding sovereignty, privatization, environmental stewardship, and human rights in extraterrestrial contexts. By analyzing these fictional projections, this article argues for a proactive, imaginative …
Hybrids As Undeserving And The Enduring Legacy Of Eugenics In Modern Conservation Policies, Maria-Vittoria Carminati, Andrew Martin
Hybrids As Undeserving And The Enduring Legacy Of Eugenics In Modern Conservation Policies, Maria-Vittoria Carminati, Andrew Martin
Seattle Journal of Technology, Environmental, & Innovation Law
This article explores the overlooked legacy of eugenics at the root of modern conservation, tracing how early conservationists—many of whom were also vocal eugenicists—shaped our definitions of species, purity, and protection. By examining the deep entanglement of racialized science and environmental policy, I argue that hybrids have been systematically excluded from protection, not because of well-founded scientific reasoning, but because of a century-old ideology rooted in the fear of impurity. It's time for conservation to evolve beyond these outdated frameworks and embrace a future-forward, adaptationist approach—one that recognizes hybrids not as mistakes, but as natural responses to a changing world …
Leadership In Quality Improvement In Academic Children’S Hospitals, Tiffany Enriquez
Leadership In Quality Improvement In Academic Children’S Hospitals, Tiffany Enriquez
Walden Dissertations and Doctoral Studies
To orient children’s academic leaders to basic competency in quality improvement (QI) practices, academic children’s hospitals must overcome leadership diversity deficits and prepare for QI practice readiness. Leadership is a key factor in enhancing patients’ care outcomes, though practice models do not allow for organizational advancements. The distributed leadership (DL) theory on leadership applies in contexts where the leadership role in QI is not solely centralized to a single individual but is decentralized and spread to include all parties involved. This paper sought to determine the effects of leadership on QI in children’s hospitals and further establish the best leadership …
Online Graduate Academic Experiences Of Adults With Bipolar Disorder, Paola Ann Faiman-Mullins
Online Graduate Academic Experiences Of Adults With Bipolar Disorder, Paola Ann Faiman-Mullins
Walden Dissertations and Doctoral Studies
Research regarding older adults with hidden disabilities in the field of adult online learning remains scarce, including a lack of research on older adults with a diagnosis of bipolar disorder. Although the needs and struggles of college students with bipolar disorder aged 18-25 in online learning have been identified, few studies have been done to uncover the needs and struggles of older learners with bipolar disorder aged 40-65. This study explored the academic experiences of these individuals to better understand their unidentified and unmet needs. This study was grounded within the community of inquiry framework. This basic qualitative study recruited …
Navigating The Labyrinth: Transition Planning Process For Reintegration Of Inmates With Chronic Illnesses And Disabilities, Courtney Ashley Dean
Navigating The Labyrinth: Transition Planning Process For Reintegration Of Inmates With Chronic Illnesses And Disabilities, Courtney Ashley Dean
Walden Dissertations and Doctoral Studies
Most offenders face challenges with successfully reintegrating, especially those living with chronic illness and/or disabilities. Transition interventions employed by mental health professionals are not universal and vary from facility to facility. While recidivism, community stigmatization, reoffending, and reconviction are explored in extant literature, little has been done to examine the difficulties faced by the professionals who work with this population as they get ready to plan for transitioning this disenfranchised group back into society. This study is an exploration of the role of professional counselors in facilitating successful transition planning for inmates living with chronic illnesses and/or disabilities. Guided by …
Standardizing Ipv Screening: A Path Toward Equity In Community Health, Andrea K. Munoz Vera
Standardizing Ipv Screening: A Path Toward Equity In Community Health, Andrea K. Munoz Vera
Master's Projects and Capstones
Intimate Partner Violence (IPV) is a widespread public health issue that disproportionately affects women and underserved communities, particularly in immigrant and Spanish-speaking populations. Despite national recommendations to conduct routine IPV screening in clinical settings, many healthcare providers lack the tools, training, and workflows needed to screen consistently and respond effectively. This quality improvement project aimed to standardize IPV screening using the Hurt, Insulted, Threatened, Screamed screening tool within the electronic health record at a community-based health clinic and provide targeted education to Medical Assistants, who are often the first point of contact during patient intake. The intervention included a culturally …
Intimate Partner Violence Prevention And Intervention At A Primary Care Clinic, Atticus Madrid
Intimate Partner Violence Prevention And Intervention At A Primary Care Clinic, Atticus Madrid
Master's Projects and Capstones
Abstract
Intimate partner violence (IPV) is a massive health concern in the Spanish-speaking community. There is a high rate IPV, worsening by factors such as language barriers, cultural stigma, and the constant fear of deportation. Resent data underscores the need for standardized IPV screening and trauma-informed care, thus supporting early recognition and intervention. The aim of this Quality Improvement (QI) project is to increase IPV detection rate by 25% from March 10, 2025, to April 15, 2025, in an San Francisco community clinic using an electronic tool called a HITS (Hurt, Insult, Threaten, Scream) and by trauma-informed staff training. Methods …
A Century Of Hypomethylating Agent: A Remarkable Response To Azacitidine Monotherapy For Relapsed Acute Myeloid Leukemia - A Case Report, Chetan Jeurkar, Amry Majeed, Lindsay Wilde, Gina Keiffer, Margaret Kasner
A Century Of Hypomethylating Agent: A Remarkable Response To Azacitidine Monotherapy For Relapsed Acute Myeloid Leukemia - A Case Report, Chetan Jeurkar, Amry Majeed, Lindsay Wilde, Gina Keiffer, Margaret Kasner
Department of Medical Oncology Faculty Papers
INTRODUCTION: Acute myeloid leukemia (AML) is a disease of the elderly with a median age at diagnosis of 68 and with a very poor prognosis outside of those patients who have cytogenetic and/or molecular findings which confer a better prognosis. Most fit patients are treated with chemotherapy and then allogeneic hematopoietic stem cell transplant if they are intermediate or poor risk by ELN 2022 criteria (aSCT). aSCT is the mainstay of curative treatment although many patients are not candidates due to age, performance status, and comorbidities. In patients who are not candidates for curative treatment, low-intensity chemotherapy regimens, including monotherapy …
Unlv Department Of Physical Therapy And The Fine Arts Clinic For Health And Injury Prevention, Madeline Cosgrove, Ashton Johnson, Keith Lopez, Diana Nguyen
Unlv Department Of Physical Therapy And The Fine Arts Clinic For Health And Injury Prevention, Madeline Cosgrove, Ashton Johnson, Keith Lopez, Diana Nguyen
UNLV Theses, Dissertations, Professional Papers, and Capstones
At the collegiate of performing arts, those who participate in classes and performances will often be at risk for musculoskeletal injury due to repetition and specific patterns of their movements. The establishment of a pro-bono physical therapy clinic for students enrolled in undergraduate and graduate-level fine arts programs may improve healthcare access for this often underserved community. The goals of this service learning project were to provide injury-prevention screenings to dancers and administer specialized physical therapy (PT) services in the form of evaluations and treatments to all students in the UNLV (University of Las Vegas, Nevada) College of Fine Arts …
The Effect Of Amputation And Prosthesis Use On The Ability To Differentiate Between Surfaces Underfoot, Allen Paul F. Aquino, Bradley C. Belasco, Kara D. Hlebak, Amanda B. Lewin
The Effect Of Amputation And Prosthesis Use On The Ability To Differentiate Between Surfaces Underfoot, Allen Paul F. Aquino, Bradley C. Belasco, Kara D. Hlebak, Amanda B. Lewin
UNLV Theses, Dissertations, Professional Papers, and Capstones
Background/ Purpose: There is limited understanding of how the sensory deficits associated with lower limb amputation (LLA) impact mobility during daily life. As a first step to developing this understanding, the aim of this study was to determine to what extent people with LLA can identify differences in commonly encountered walking surfaces beneath their feet. We hypothesized that people with LLA would demonstrate a poorer ability to discriminate between different surfaces than people without an amputation, and that discrimination ability would be surface characteristic-specific; discrimination would be poor for roughness discrimination due to the lack of plantar sensation in the …
Feasibility And Acceptability Of Tap Dance As A Therapeutic Intervention For Adults With Lower Limb Amputation: A Pilot Study, Julianne Roser, Allison Strande, Bailey Taggart
Feasibility And Acceptability Of Tap Dance As A Therapeutic Intervention For Adults With Lower Limb Amputation: A Pilot Study, Julianne Roser, Allison Strande, Bailey Taggart
UNLV Theses, Dissertations, Professional Papers, and Capstones
Objectives: This study aimed to evaluate the feasibility, acceptability, and potential efficacy of an 8-week adapted tap dance program as a therapeutic intervention for individuals with lower limb amputation (LLA).
Methods
Three participants with LLA (two with unilateral transfemoral amputation and one with bilateral transtibial amputations) attended weekly 1-hour tap dance classes, with movements adapted for their needs and mobility aids and dance barres available as needed. The Physical Activity Enjoyment Scale (PACES) and participant feedback assessed acceptability. Functional mobility, balance and quality of life were measured using the Activities-Specific Balance Confidence (ABC) scale, Timed Up-and-Go (TUG), Berg Balance Scale …
Effects Of Altered Somatosensory Input On Gait Kinetics And Kinematics Via Different Footwear In Individuals With Chronic Post-Stroke Hemiparesis, Daniela Casillas, Lesley Ruiz
Effects Of Altered Somatosensory Input On Gait Kinetics And Kinematics Via Different Footwear In Individuals With Chronic Post-Stroke Hemiparesis, Daniela Casillas, Lesley Ruiz
UNLV Theses, Dissertations, Professional Papers, and Capstones
Purpose/Hypothesis: Individuals with post-stroke hemiparesis walk with significant asymmetries, leading to slow, effortful walking, and a high risk of falls. One contributing factor is altered sensation on the plantar surface. Studies examining altered somatosensory input via insoles, vibration and other tactile stimuli observed improvements in hemiparesis gait. This study investigates whether altering somatosensory input through different footwear can affect kinetics, kinematics and muscle activity during walking post-stroke. We hypothesized the barefoot conditions would have increased dorsiflexion (heel-strike, swing), increased plantarflexion during toe-off, increased muscle activity and kinetics, compared to memory foam conditions.
Participants: 13 individuals with chronic post-stroke hemiparesis (4F/9M, …
Dry And Wet Deposition Of Atmospheric Microplastics In Las Vegas, Nevada, Laine Adame
Dry And Wet Deposition Of Atmospheric Microplastics In Las Vegas, Nevada, Laine Adame
UNLV Theses, Dissertations, Professional Papers, and Capstones
Plastics have been one of the most widely used man-made materials since their inception, and production is expected to grow by five percent every year. Plastic waste has become a growing global environmental issue. Primary MPs are plastics that are created to be intentionally tiny for their specific functional purpose. Secondary microplastics (MPs) are byproducts of plastic waste occurring due to the breakdown of larger plastics resulting in the presence and accumulation of MPs in the environment. MPs are defined as tiny particles of plastic between 5 mm and 1 μm in size. MPs have been found in the deep …
Empowering Educators To Improve Social Emotional Behaviors Among K-8 Students: Quality Improvement Project, Paige Yael Bister
Empowering Educators To Improve Social Emotional Behaviors Among K-8 Students: Quality Improvement Project, Paige Yael Bister
UNLV Theses, Dissertations, Professional Papers, and Capstones
Social and emotional learning (SEL) encompasses essential skills for effectively managing and expressing emotions. Studies have shown that SEL strengthens early education while supporting students' lifelong success by fostering positive behaviors within and beyond the classroom. In school settings, occupational therapists (OTs) aim to empower children to thrive as students and as social beings through targeted interventions and educational support for parents and teachers. In private school settings, limited access to occupational therapy services may impact teachers' ability to implement SEL strategies effectively.This capstone project addressed gaps in teachers' knowledge and confidence in applying the Zones of Regulation SEL curriculum …
High Dynamic Range Actively Quenched Silicon-Germanium Single-Photon Avalanche Diodes, Abraham Castaneda
High Dynamic Range Actively Quenched Silicon-Germanium Single-Photon Avalanche Diodes, Abraham Castaneda
UNLV Theses, Dissertations, Professional Papers, and Capstones
Single-photon avalanche diodes (SPADs) are solid-state devices capable of providing large current pulses in the milliampere range in response to incident photons. The large gain inherent to SPADs makes them a popular technology for photon-counting applications, but their operation can be hindered by long recharge times, which necessitates the use of active quenching to reduce dead times and increase detection rates. For the prompt gamma/neutron radiation experiments conducted at the Nevada National Security Site, photomultiplier tubes (PMTs) have been the primary photodetector of choice, but their continued use is expected to dwindle as it becomes increasingly difficult to source quality …
Highways To Hell: How The Intersections Of Cinema, Rock Music And The Resurgence Of Evangelicalism Influenced The 1985 Senate Hearing On Rock Music, David J. Fewell
Highways To Hell: How The Intersections Of Cinema, Rock Music And The Resurgence Of Evangelicalism Influenced The 1985 Senate Hearing On Rock Music, David J. Fewell
UNLV Theses, Dissertations, Professional Papers, and Capstones
The Senate hearing on the “Contents of Music and the Lyrics of Records, held on September 19, 1985, was as much a popular culture event as a public airing of concerns about explicit content in music. Much has been written about the significance of the Parents’ Music Resource Center (PMRC), the Senate hearing and the issues it engaged in, and how it colored conversations about censorship of the arts, the effectiveness of rating systems to police popular media and the effects of media on children’s behavior and development. The thesis will explore aspects of formative trends that influenced the PMRC’s …
Efficacy Of Dorsal Application Of Kt For Carpal Tunnel Syndrome In Esport Gamers: A Randomized Clinical Trial, Anthony Foreman
Efficacy Of Dorsal Application Of Kt For Carpal Tunnel Syndrome In Esport Gamers: A Randomized Clinical Trial, Anthony Foreman
UNLV Theses, Dissertations, Professional Papers, and Capstones
This doctoral study investigated the impact of the dorsal application of kinesiotape on carpal tunnel syndrome (CTS) symptoms and performance among Esport gamers. The study was conducted in controlled environments at the UNLV Esports Lounge, Black Fire Innovation, and the Musculoskeletal Lab using a randomized two-group pretest-posttest design. To maintain ecological validity, participants were permitted to use personally owned gaming peripherals (e.g., computer mouse), and all received brief instruction on proper body mechanics to promote consistency during testing. Participants (n = 11) were systematically assigned by order of registration to either an intervention group receiving dorsal application of kinesiotape on …
Past Instability, Future Consequences: Evaluating The Relationship Between Pre-Incarceration Housing Status And Rearrest In The Paroled Population Of Colorado From 2013-2023, Sarah E. Maynard
UNLV Theses, Dissertations, Professional Papers, and Capstones
Paroled individuals re-enter society at a disadvantage with an increased risk of housing instability, mental and physical health concerns, and difficulty finding gainful employment. Houselessness places a significant burden on parolees and may increase their risk of rearrest. This retrospective study aimed to evaluate the association between pre-incarceration housing status and rearrest among non-violent parolees (n=23,786) in Colorado from 2013-2023. The Sequential Intercept Model was used as a framework to identify the point in the criminal justice process that rearrest occurred and to identify opportunities for new intercepts (e.g., housing interventions). Descriptive statistics were calculated, and logistic regression with estimated …
Capturing The Intersection Of Black-American, Muslim Males And Education: Exploring Their Attitudes, Perceptions, And Lived Experiences Within An Islamic Consciousness, Kirk A. Talib-Deen
Capturing The Intersection Of Black-American, Muslim Males And Education: Exploring Their Attitudes, Perceptions, And Lived Experiences Within An Islamic Consciousness, Kirk A. Talib-Deen
UNLV Theses, Dissertations, Professional Papers, and Capstones
This dissertation explored the lived realities of Black-American, Muslim males and their attitudes, perceptions, histories, and endurances toward higher learning in America. It attempted to join and contribute to the more significant, historical, and extant conversations and literature on Black-American males and education, as well as their successes and failures. This dissertation adds to the dearth of literature on the intersection of Black-American, Muslim males, and education, and using jazz as an epistemological way of navigating and organizing the content, the research works to uncover, locate, and define an Islamic consciousness. While negating racist histories concomitant with the American narrative …
Piloting The Inclusion Of Dollar Stores In The Modified Retail Food Environment Index (Mrfei) In Urban Clark County, Nevada, Tiana T. Tu
UNLV Theses, Dissertations, Professional Papers, and Capstones
Food insecurity is the condition of having limited or uncertain access to adequate food. It contributes to poor diet-related health outcomes which are in turn influenced by the food environment. The Centers for Disease Control and Prevention (CDC) developed the Modified Retail Food Environment Index (mRFEI) to characterize food environments by measuring the proportion of healthy and non-healthy retailers. The CDC mRFEI considers a variety of establishments but fails to include dollar stores, which contribute to the food environment by offering food and, in some cases, fresh produce. This study proposed an “expanded mRFEI” that modified the CDC mRFEI methodology …
The Mindful Officer: Enhancing Officer Mental, Physical, And Social Wellness Through Resilience Training, Tanya Dudinskaya
The Mindful Officer: Enhancing Officer Mental, Physical, And Social Wellness Through Resilience Training, Tanya Dudinskaya
UNLV Theses, Dissertations, Professional Papers, and Capstones
The issue of mental health among the U.S. population has gained national attention, with numerous wide-scale initiatives aimed at providing resources for the public. However, certain professional populations encounter unique challenges in their occupation and often lack specific support for their mental and physical health needs that stem from long-term exposure to unpredictable stressors. One population facing these issues is law enforcement. Police officers regularly experience chronic stress related to their job demands, as they manage high-pressure situations and exposure to significant trauma, all while being under increased public scrutiny in recent years. Previous research has highlighted the effects of …
Leveraging Data Pipeline And Llm To Advance Patient Safety Event Studies, Fagun Shah, Yue Yu, Yuheng Shi, Yang Gong
Leveraging Data Pipeline And Llm To Advance Patient Safety Event Studies, Fagun Shah, Yue Yu, Yuheng Shi, Yang Gong
Faculty, Staff and Student Publications
Research utilizing the open-access MAUDE database frequently reveals unclear methodologies for extracting and processing medical device report (MDR) data, reducing reproducibility and consistency. By harnessing the OpenFDA API and our MAUDE extract-transform-load (ETL) pipeline that standardizes the extraction and transformation of MDR data, this project explores how a large language model (LLM) can be employed to analyze free-text narratives in MDRs, enhancing the accuracy and efficiency of event categorization. The ETL-LLM approach is demonstrated through MDRs related to endoscopic mucosal resection, with potential applications extending to other devices and patient issues. Additional efforts are necessary to expand the size and …
The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons Of The Transcriptomic Landscapes Across Mouse Models, Ling Cai, Fangjiang Wu, Qinbo Zhou, Ying Gao, Bo Yao, Ralph J Deberardinis, George K Acquaah-Mensah, Vassilis Aidinis, Jennifer E Beane, Shyam Biswal, Ting Chen, Carla P Concepcion-Crisol, Barbara M Grüner, Deshui Jia, Robert A Jones, Jonathan M Kurie, Min Gyu Lee, Per Lindahl, Yonathan Lissanu, Corina Lorz, David Macpherson, Rosanna Martinelli, Pawel K Mazur, Sarah A Mazzilli, Shinji Mii, Herwig P Moll, Roger A Moorehead, Edward E Morrisey, Sheng Rong Ng, Matthew G Oser, Arun R Pandiri, Charles A Powell, Giorgio Ramadori, Mirentxu Santos, Eric L Snyder, Rocio Sotillo, Kang-Yi Su, Tetsuro Taki, Kekoa Taparra, Phuoc T Tran, Yifeng Xia, J Edward Van Veen, Monte M Winslow, Guanghua Xiao, Charles M Rudin, Trudy G Oliver, Yang Xie, John D Minna
The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons Of The Transcriptomic Landscapes Across Mouse Models, Ling Cai, Fangjiang Wu, Qinbo Zhou, Ying Gao, Bo Yao, Ralph J Deberardinis, George K Acquaah-Mensah, Vassilis Aidinis, Jennifer E Beane, Shyam Biswal, Ting Chen, Carla P Concepcion-Crisol, Barbara M Grüner, Deshui Jia, Robert A Jones, Jonathan M Kurie, Min Gyu Lee, Per Lindahl, Yonathan Lissanu, Corina Lorz, David Macpherson, Rosanna Martinelli, Pawel K Mazur, Sarah A Mazzilli, Shinji Mii, Herwig P Moll, Roger A Moorehead, Edward E Morrisey, Sheng Rong Ng, Matthew G Oser, Arun R Pandiri, Charles A Powell, Giorgio Ramadori, Mirentxu Santos, Eric L Snyder, Rocio Sotillo, Kang-Yi Su, Tetsuro Taki, Kekoa Taparra, Phuoc T Tran, Yifeng Xia, J Edward Van Veen, Monte M Winslow, Guanghua Xiao, Charles M Rudin, Trudy G Oliver, Yang Xie, John D Minna
Faculty, Staff and Student Publications
Lung cancer, the leading cause of cancer mortality, exhibits diverse histological subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung cancer, but data from these models are disparate, siloed, and difficult to compare in a centralized fashion. In this study, we established the Lung Cancer Autochthonous Model Gene Expression Database (LCAMGDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets covering 974 samples from genetically engineered mouse models (GEMMs), 368 samples from carcinogen-induced models, and 12 samples from a spontaneous model. Meticulous curation and collaboration with data depositors produced a robust and comprehensive database, …
G-Quadruplex Stabilizer Cx-5461 Effectively Combines With Radiotherapy To Target Α-Thalassemia/Mental Retardation X-Linked-Deficient Malignant Glioma, Sharvari Dharmaiah, Prit Benny Malgulwar, William E Johnson, Brandon A Chen, Vladislav Sharin, Benjamin T Whitfield, Christian Alvarez, Vasudev Tadimeti, Ahsan S Farooqi, Jason T Huse
G-Quadruplex Stabilizer Cx-5461 Effectively Combines With Radiotherapy To Target Α-Thalassemia/Mental Retardation X-Linked-Deficient Malignant Glioma, Sharvari Dharmaiah, Prit Benny Malgulwar, William E Johnson, Brandon A Chen, Vladislav Sharin, Benjamin T Whitfield, Christian Alvarez, Vasudev Tadimeti, Ahsan S Farooqi, Jason T Huse
Faculty, Staff and Student Publications
Background: Inactivation of α-thalassemia/mental retardation X-linked (ATRX) represents a defining molecular feature in large subsets of malignant glioma. ATRX deficiency gives rise to abnormal G-quadruplex (G4) DNA secondary structures, enhancing replication stress and genomic instability. Building on earlier work, we evaluated the extent to which pharmacological G4 stabilization selectively enhances DNA damage and cell death in ATRX-deficient preclinical glioma models.
Methods: Using the G4 stabilizer CX-5461, we treated patient-derived glioma stem cells (GSCs) in vitro and GSC flank and intracranial murine xenografts in vivo to evaluate efficacy as both a single agent and in combination with ionizing radiation (IR), the …