Digital Commons Network^™

Detection Of Enterovirus Rna In Pancreas And Lymphoid Tissues Of Organ Donors With Type 1 Diabetes, Jutta E Laiho, Sami Oikarinen, Sofia Morfopoulou, Maarit Oikarinen, Ashlie Renner, Daniel Depledge, Matthew C Ross, Ivan C Gerling, Judith Breuer, Joseph F Petrosino, Vincent Plagnol, Alberto Pugliese, Antonio Toniolo, Richard E Lloyd, Heikki Hyöty, Npod-Virus Group

Center for Medical Ethics and Health Policy Staff Publications

Aims/hypothesis: The nPOD-Virus group collaboratively applied innovative technologies to detect and sequence viral RNA in pancreas and other tissues from organ donors with type 1 diabetes. These analyses involved the largest number of pancreas samples collected to date. The aim of the current work was to examine the presence of enterovirus RNA in pancreas and lymphoid tissues of organ donors with and without type 1 diabetes.

Methods: We analysed pancreas, spleen, pancreatic lymph nodes and duodenum samples from the following groups: (1) donors with type 1 diabetes (n=71) with (n=35) or without (n=36) insulin-containing islets; (2) donors with single or …

Transmedial Econarratology: Environment And The Subject Of Science Fiction, Joseph R. Boisvere

Dissertations, Theses, and Capstone Projects

This dissertation argues that narrators are constructed by their interactions with diegetic space and time in an ecological relationship. This argument draws upon Erin James’s work on econarratology, particularly her book The Storyworld Accord: Econarratology and Postcolonial Narratives, putting her theories of narrating time and place in dialogue with contemporary “unnatural” narratology as theorized by scholars such as Jan Alber and Brian Richardson. Science fiction (SF) offers a rich complement to these theoretical stances. I also focus much of my dissertation on how narratology works across and is influenced by specific media, featuring literary, audiovisual, and digital media, including novels, …

The Origins Of German Industrialization: The Transition To Capitalism In Prussian Agriculture, Daniel C. Colligan

Dissertations, Theses, and Capstone Projects

This dissertation seeks to explain the origins of German industrialization. Historical accounts of German industrialization often chronicle the process of its development but leave reasons for its initiation unexplained. Theories that have attempted to locate the roots of rapid German economic growth have been found to be empirically unsatisfactory, and thus the accepted story has defaulted to a gradualist narrative which conceptualizes economic behavior as fundamentally unchanging throughout German history. This dissertation challenges this reigning view, attempting to provide an explanation for why Germany embarked on a rapid economic growth trajectory in the nineteenth century whereas many other similarly situated …

Parametrization Of Formal Norm Compatible Sequences, Joseph Dicapua

Dissertations, Theses, and Capstone Projects

We give a classification of power series parametrizing Lubin-Tate trace compatible sequences. This proof answers a question posed in the literature by Berger and Fourquaux. Lubin-Tate trace compatible sequences are a generalization of norm compatible sequences, which arise in Iwasawa theory and local class field theory. The result we prove generalizes the interpolation theorem proved by Coleman in the classical norm compatible sequence case. We also, jointly with Victor Kolyvagin, give a method for finding such series explicitly in certain special cases.

Survey Of The Diagnostic, Rehabilitative, Educational, And Inter-Professional Changes In The Profession Of Audiology, Leah Joshowitz

Dissertations, Theses, and Capstone Projects

Background: The profession of audiology has undergone dramatic changes since its inception. A survey of audiologists working in a variety of settings was conducted to gain insight into their perspective on how the scope of audiology practice has changed overtime. Participants responded to an open-ended questionnaire with questions ranging from queries about the expansion of knowledge base in topics such as advanced diagnostics, technological advances, national regulations, educational requirements, and inter-professional collaborations. The implications of the findings regarding the evolution of the current scope of practice and how it can be altered are discussed below.

Methods: An open-ended questionnaire was …

The Warmth Of Welcome Of Refugees And Migrants In The Western Balkans, Zylfie Demushi

Dissertations, Theses, and Capstone Projects

Despite it getting harder to immigrate to the EU legally, refugees from the global south still try to immigrate to developed countries in the EU through transit states in the Balkan region. In search of refuge from wars, better economic prospects, or family reunions, over the past decade, many migrants have attempted to travel North through transit states like North Macedonia, Albania, and Montenegro. A qualitative study was conducted following a theoretical approach by Adamson and Tsourapas (2019), who categorized migration states in the global south into three types, i.e., nationalizing, developmental, or neoliberal. The paper followed this approach to …

Elucidating The Roles Of Eukaryotic Initiation Factors Involved In Dap5 Mediated Translation, Jacob Nk Quartey

Dissertations, Theses, and Capstone Projects

Translation initiation in eukaryotes is a highly regulated process essential for accurate protein synthesis. It is a dynamic process that involves a complex interplay between messenger RNAs (mRNAs), ribosomal subunits, and a host of initiation factors, ensuring precise start codon selection and the subsequent assembly of the translation machinery. This process has well been known to be mediated by the eukaryotic Initiation Factor (eIF4F), which consists of the cap binding protein eIF4E, the scaffolding protein eIF4GI, and the helicase factor eIF4A.The recognition and binding of eIF4E to the m⁷G cap structure of the mRNA is essential for the …

Belonging Against The Odds: Exploring Restorative Justice Practices As Pathways To Foster Belonging In New York City Transfer Schools, Miguel Rodriguez

Dissertations, Theses, and Capstone Projects

The U.S. education system perpetuates structural inequities that disproportionately affect Black students with the School-to-Prison Pipeline (STPPL) criminalizing them through Zero-Tolerance policies. Transfer schools are often a last resort for students pushed out of traditional schools provide a lens to examine the impact of Restorative Justice Practices (RJP) and Black student representation on belonging. This quantitative dissertation study analyzes secondary data from the NYC Department of Education using multivariate models to explore the relationship between RJPs and sense of belonging (SOB). Model 1 found that discussing feelings and emotions at school (Tier 1 RJP) had the strongest association with SOB …

Unveiling The Vital Role Of Blue Carbon In Mangroves: Understanding Environmental Influences, Jahnelle Howe

Dissertations, Theses, and Capstone Projects

Mangrove ecosystems provide essential ecological services, including carbon sequestration, coastal protection, and heavy metal retention. However, their resilience and functionality are increasingly influenced by hurricanes, climate variability, and anthropogenic contamination. This dissertation integrates three research efforts examining mangrove canopy dynamics, carbon storage, and heavy metal contamination in two Puerto Rican mangrove systems: La Parguera and Laguna Grande.

Using remote sensing techniques (LiDAR and NDVI analysis), we assessed the impact of Hurricane Maria (Category 4, 2017) on mangrove canopy structure and vegetation health. Results revealed significant canopy height loss, with greater damage at Laguna Grande, where pre-storm canopy height and human …

Creative Coding Communities: Exploring The Relationship Between Scratch Use And Child Well-Being, Nikita Khalid

Dissertations, Theses, and Capstone Projects

This international study assessed the relationship between the use of Scratch, the world's largest coding community for children, and child well-being. Specifically, the study focused on the presence of well-being indicators in the RITEC-8 framework (RITEC, 2024) including creativity, relationships, competence, and autonomy within Scratch users’ behaviors. The participants (N = 17,315) included children aged between 8 and 16 who used Scratch in 2023 and came from 29 countries. The study examined trends in Scratchers’ behaviors including project creation, sharing, studio curation, and socialization based on their country of origin, gender and age. The data were used to construct user …

Self-Reported Audiological And Vestibular Symptoms Associated With Lyme Disease, Daniella A. Bryan

Dissertations, Theses, and Capstone Projects

Background:

Lyme disease, an infectious vector-borne illness, is carried by the deer tick, Ixodes scapularis, which harbor the spirochete, Borrelia burgdorferi, affecting hundreds of thousands of people in the United States annually. Lyme disease has a multitude of clinical presentations and overlaps with other complex illnesses, making diagnosis and treatment a medical challenge. This distinct bacterium can migrate into any organ system through the mediums of soft tissue, the lymphatic system, and the circulatory system. Despite its prevalence and range in symptomatology, minimal research has been conducted to identify distinct audiological and vestibular symptoms associated with a Lyme …

Spirometry: For The Winds In Us, Kendall Allison

Dissertations, Theses, and Capstone Projects

Spirometers are devices used to measure lung capacity. This capstone is a creative study of what restores our breathing aptitude as a response to the suffocating and alienating consequences of whiteness for people racialized as white. The project is a sequence of lyric essays. The first lyric essay frames whiteness as a condition of exile and examines the cultural and emotional currents that shore it up. I use exile as a frame to emphasize the intensity of the spiritual and cultural alienation that people racialized as white experience. I also contextualize the dis-ease of suicide in my own lineage, and …

The "Self" In Crisis: A Study Of Audre Lorde's The Cancer Journals, Golnaz Salehkarimi

Dissertations, Theses, and Capstone Projects

In this thesis, I focus on The Cancer Journals and explore how Audre Lorde articulates the chaos followed by breast cancer in her life: what is the nature of the crises? What aspects of her life are largely affected by it? How it unsettles her understanding of time and place, how her daily life, work, relationships, and future plans get affected, and how her self-image and her agency and subjectivity are threatened. Relying on theories of women’s autobiographies, women’s writings, and illness narratives, I explore Lorde’s ways of writing about her body and emotions to regain her sense of self …

Clinical Manifestations, Disease Penetrance, And Treatment In Individuals With Socs1 Insufficiency: A Registry-Based And Population-Based Study, Jerome Hadjadj, Anna Wolfers, Oleg Borisov, Derek Hazard, Ronan Leahy, Marie Jeanpierre, Alexandre Belot, Shahrzad Bakhtiar, Fabian Hauck, Pui Y Lee, Stefano Volpi, Serena Palmeri, Vincent Barlogis, Nathalie Aladjidi, Georg Ebetsberger-Dachs, Jerome Avouac, Fabienne Charbit-Henrion, Morgane Cheminant, Jean Donadieu, Sujal Ghosh, David P Hoytema Van Konijnenburg, Julia Körholz, Jacinta Bustamante, Jeremie Rosain, Lisa Forbes Satter, Ingrid Selmeryd, Georgios Sogkas, Benedicte Neven, Frederic Rieux-Laucat, Stephan Ehl

Faculty, Staff and Students Publications

Background: Suppressor of cytokine signalling 1 (SOCS1) insufficiency is an inborn error of immunity affecting the negative regulation of cytokine and growth factor signalling. We aimed to enhance the understanding of clinical manifestations, disease trajectories, disease penetrance, and the effect of Janus kinase (JAK) inhibition in individuals with SOCS1 insufficiency.

Methods: This study used data from two independent cohorts: the European Society for Immunodeficiencies (ESID) registry and the UK Biobank. Participants from the ESID registry were from nine European countries (Austria, Belgium, France, Germany, Ireland, Italy, Portugal, Sweden, and Ukraine), China, Taiwan, and the USA. Participants from the ESID registry …

Injectable Ionic Hydrogel Conductors: Advancing Material Design To Transform Cardiac Pacing, Gabriel J Rodriguez-Rivera, Allison Post, Mathews John, Derek Bashe, Fei Xu, Trace Larue, Abbey Nkansah, Megan Wancura, Malgorzata Chwatko, Christina Waldron, Nikhith Kalkunte, Janet Zoldan, Mathieu Arseneault, Abdou Elgalad, Manuel K Rausch, Mehdi Razavi, Elizabeth Cosgriff-Hernandez

Faculty, Staff and Students Publications

Direct pacing of the mid myocardium where re-entry originates can be used to prevent ventricular arrhythmias and circumvent the need for painful defibrillation or cardiac ablation. However, there are no pacing electrodes small enough to navigate the coronary veins that cross these culprit scar regions. To address this need, we have developed an injectable ionically conductive hydrogel electrode that can fill the epicardial coronary veins and transform them into flexible electrodes. A new hydrogel chemistry based on a polyether urethane diacrylamide macromer was developed that matches myocardial stiffness and is resistant to hydrolysis. Conductivity was imparted using ionic precursor solutions …

Implementing A Pre-Matriculation Program Targeting Self-Efficacy, Institutional Belongingness, And Metacognition, Steve Caloudas, Nital Appelbaum, Jesus Vallejo, Nadia Ismail, Andrea Stolar

Faculty and Staff Publications

Students come to medical school with diverse backgrounds and experiences. Accordingly, many schools have developed pre-matriculation programs to support students' transition into medical education, especially for those whose educational path may not have offered the same breath of opportunities as their incoming counterparts. Baylor College of Medicine established a pre-matriculation program for students from early assurance programs and non-traditional pathways to address gaps in student support and normalize help-seeking behavior. This program took place over 2 weeks and was developed with leadership and student partners. Participants included 21 students who completed baseline and post-program surveys. Results indicated that a focus …

Deconstructing The Extended Focused Assessment With Sonography In Trauma (E-Fast) As A Roadmap For Longitudinal Integration Of Point Of Care Ultrasound Education Within Undergraduate Medical Education, Cherie Tator, Maria Maldonado, Nadia Ismail, Kiyetta H Alade, Alan Riley

Faculty and Staff Publications

Point-of-care ultrasound (POCUS) has been embraced by most medical specialties, yet undergraduate medical education still has difficulty incorporating POCUS skill development and assessment. While much of the existing literature focuses on specific POCUS and/or ultrasound topics, the feasibility as well as ensuring POCUS topics are relevant to all undergraduate medical education (UME) learners are often left unaddressed. The authors outline a novel, outcomes-driven, longitudinal POCUS curriculum designed around a "deconstructed" Extended Focused Assessment with Sonography in Trauma (E-FAST) exam, which facilitated purposeful integration of POCUS and medical imaging topics into organ system-based foundational courses. Curriculum development strategies specific to POCUS …

Bile Acid Regulation Of Xenobiotic Nuclear Receptors On The Expressions Of Orosomucoids In The Liver, Ji Ho Suh, Inyoung Cheon, Hyun-Jung Jung, Sung Ho Lee, Mi Jeong Heo, Matthew Deberge, Clavia Ruth Wooton-Kee, Kang Ho Kim

Children’s Nutrition Research Center Staff Publications

The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic nuclear receptors activated by various xenobiotics, drugs, hormones, and bile acids (BAs). Upon activation, these nuclear receptors play critical roles in regulating systemic energy homeostasis. However, precise mechanisms through which CAR and PXR influence systemic metabolism remain incompletely understood. Here, we investigated the impact of CAR and PXR on the liver-secreted hormone (i.e., hepatokine) expressions in response to BA stress such as cholic acid (CA) feeding. Our analysis revealed that several BA-activated genes, including the well-known CAR/PXR target, aldo-keto reductase family 1, member B7 (Akr1b7 …

Changes In The Fxr-Cistrome And Alterations In Bile Acid Physiology In Wilson Disease, Clavia Ruth Wooton-Kee, Hari K Yalamanchili, Islam Mohamed, Manal Hassan, Kenneth D R Setchell, Monica Narvaez Rivas, Ayse K Coskun, Vasanta Putluri, Nagireddy Putluri, Prasun Jalal, Michael L Schilsky, David D Moore

Children’s Nutrition Research Center Staff Publications

Background: Wilson disease (WD) is an autosomal recessive disorder that results in excessive hepatic copper, causing hepatic steatosis, inflammation, fibrosis, cirrhosis, and liver failure. Previous studies have revealed dysregulation of many farnesoid X receptor (FXR) metabolic target genes in WD, including the bile salt exporter pump, the major determinant of bile flow.

Methods: We tested the hypothesis that the FXR-cistrome is decreased in Atp7b-/- mice in accord with dysregulated bile acid homeostasis.

Results: FXR binding within Atp7b-/- mouse livers displayed surprising complexity: FXR binding was increased in distal intergenic regions but decreased in promoter regions in Atp7b-/- versus wild-type mice. …

Biomolecular Condensates In Immune Cell Fate, Srikanth Kodali, Caroline M Sands, Lei Guo, Yun Huang, Bruno Di Stefano

Faculty, Staff and Students Publications

Fate decisions during immune cell development require temporally precise changes in gene expression. Evidence suggests that the dynamic modulation of these changes is associated with the formation of diverse, membrane-less nucleoprotein assemblies that are termed biomolecular condensates. These condensates are thought to orchestrate fate-determining transcriptional and post-transcriptional processes by locally and transiently concentrating DNA or RNA molecules alongside their regulatory proteins. Findings have established a link between condensate formation and the gene regulatory networks that ensure the proper development of immune cells. Conversely, condensate dysregulation has been linked to impaired immune cell fates, including ageing and malignant transformation. This Review …

Navigating Emotional Transitions: A Study Of Self-Perception And Emotion In Bio-Childfree Women Entering A Blended Family, Janine Cednick

Dissertations

The transition to a blended family is an emotional and psychological adjustment for bio-childfree individuals. The present qualitative study investigated how self-concept and emotional adjustment of bio-childfree stepmothers change when they become members of their new family. With a phenomenological approach, semi-structured interviews were conducted with 12 female participants who were bio-childfree, in a committed relationship with a partner with children, and had cohabited for one year or more. The study aimed to find out how these women cope in their new role, their emotional adjustment to their transition, and the influences that impact their well-being. Thematic analysis of interviews …

Building Bridges: Union Efforts To Address Stress Among Educational Staff, Theodore Michael Hamilton

Dissertations

This mixed-methods study examines the relationship between administrative support and educator stress and burnout in a post-COVID unionized school district. Grounded in Bronfenbrenner’s Ecological Systems Theory, the Job Demands-Resources (JD-R) model, and the Transactional Model of Stress and Coping, the study surveyed 102 educational professionals and conducted semi-structured interviews with union delegates. Quantitative findings revealed that 75% of staff worked beyond contracted hours, and 63% assumed additional unpaid responsibilities. Lower levels of perceived administrative support were significantly correlated with higher burnout and greater intent to leave the profession. Qualitative thematic analysis identified key stressors, including inconsistent administrative communication, escalating student …

The Impact Of Restorative Practices Intervention On School Culture, Lisa Peloquin

Dissertations

The American educational system, historically designed to empower a few while training the majority to be docile workers, is increasingly being called upon to promote greater equity. While some reform efforts promote highly restrictive behavioral policies to boost student achievement, these approaches often serve to recreate the oppressive school systems they seek to reform. Restorative practices, an alternative approach to school reform, emphasizes creating a culture of strong relationships, where children learn the academic and social emotional skills they need to be successful. This paper presents a case study of one urban, public school’s implementation of restorative practices, examining its …

Understanding The Afghan Newcomer Experience From The Perspectives Of Teachers And Students, Elisabeth C. Trost

Dissertations

Newcomer English learners (ELs) often arrive in the United States having fled persecution, economic or political oppression, war, or natural disasters in their country of origin. They are new to the English language, new to the American school system, at times well into their educational journey, and sometimes have missed out on significant amounts of formal schooling. Many also carry trauma from the circumstances that forced them to leave their homes. Most schools are not fully equipped to welcome these students and their families into the learning community, nor are they prepared to address the unique challenges newcomer ELs face. …

Intersecting Inequities: Latinx Access To Mental Health Services, Melissa Thorson

Dissertations

This study examined barriers to mental health service utilization among Latinx populations using data from the 2022 National Survey on Drug Use and Health (NSDUH). Through the theoretical frameworks of Minority Stress Theory and Toxic Stress Theory, the study investigated the relationships between age, language proficiency, socioeconomic status, and mental health service access among different Latinx subgroups. Statistical analyses included chi-square tests, multiple regression, and mediation analyses on a sample of Latinx adults (N = 9,852). Results indicated associations between age and English proficiency (χ² = 145.23, p < .001, Cramer's V = 0.38), with 45% of adults aged 50 and older reporting limited English proficiency. Socioeconomic analysis revealed that 32% of older Latinx adults reported family incomes below $20,000, with insurance status partially mediating the relationship between income and service utilization (indirect effect = 0.15, 95% CI [0.08, 0.23]). differences in utilization rates emerged among Latinx subgroups (F(6, 1243) = 8.76, p < .001, η² = 0.12), with Mexican-origin individuals showing higher utilization (10%) compared to Puerto Rican individuals (2-3%). Age and socioeconomic status demonstrated interaction effects (β = 0.18, p < .01), while language proficiency moderated the relationship between age and service utilization (β = 0.24, p < .001). These findings suggest that barriers to mental health service utilization among Latinx populations are complex and interconnected, requiring multilevel interventions that address linguistic, cultural, and socioeconomic factors simultaneously. Implications for healthcare policy and service delivery are discussed, emphasizing the need for culturally responsive and linguistically appropriate mental health services.

Narratives Of Latina Teacher Candidates On Subtractive Schooling Experiences And Their Language Identity, Joao Goebel

Dissertations

The subtractive nature of bilingual education in the United States has long impacted the language identities of Latinx students. Despite being raised in multilingual environments, many are schooled in systems that devalue their home languages and prioritize English-only instruction. This study explored how these dynamics influenced Latina teacher candidates’ perceptions of their own bilingualism and professional identities. The purpose of the study was to examine how Latina teacher candidates understood and constructed their language identities in the context of their K–12 and higher education experiences. The study used narrative research centered on four Latina teacher candidates enrolled in an undergraduate …

Narratives Of Jewish American Public School Educators Amid Rising Antisemitism Post October 7, 2023, Cassandra Schwartz

Dissertations

This study investigated how Jewish American public school educators are responding to rising antisemitism post-October 7, 2023. While research exists on global antisemitism, the experiences of Jewish educators within the unique context of American public schools represent a significant and under-explored gap in academic literature. A qualitative narrative research approach, grounded in critical theory, was employed. Data were collected through semi-structured interviews with eight Jewish American public school educators and analyzed thematically. The findings revealed participants’ experiences of a heightened sense of fear and silence from colleagues and institutions, leading to feelings of isolation and being unsupported. Critically, this study …

Impact Of Student Voice In The (Dis) Engagement Of Middle School Students In Urban Elementary School And Academic Achievement, Valandra N. Lloyd

Dissertations

This formative mixed-methods evaluation study explores the impact of culturally inclusive teaching practices on student voice, engagement, and academic outcomes among middle school students in an urban elementary school. Grounded in the theoretical frameworks of Culturally Relevant Pedagogy (Ladson-Billings), Culturally Responsive Teaching (Gay), and Culturally Sustaining Pedagogy (Paris & Alim), the study addresses persistent academic disparities experienced by students of color. Using classroom observations, student surveys, student focus groups, and teacher interviews, the research examines how teacher facilitation and inclusive classroom environments affect behavioral, emotional, and cognitive engagement. Findings will inform actionable strategies to amplify student voice and promote culturally …

‘Making A Positive Environmental Impact’: Exploring The Role Of Volunteering At A Campus Community Garden, Dina Izenstark, Barbara Ann Boone

Faculty Research, Scholarly, and Creative Activity

Promoting sustainability in higher education is a social and environmental imperative. This paper explores how and why volunteering at a campus community garden (CCG) can serve as a unique context for promoting sustainability. Twenty-five undergraduate students between the ages of 18 and 27, who had volunteered at a campus garden, participated in individual semi-structured interviews. A majority of participants identified as female (80%) and Asian American (52%). Using reflexive thematic analysis, we first found students were motivated to volunteer for personal and academic reasons as well as to learn more about gardening. Childhood gardening experiences influenced participants’ re-engagement as adults. …

Beyond Country: Southern Language And Identity In North Mississippi, Meredith Hilliard

Dissertations, Theses, and Capstone Projects

This dissertation is about the language of the US South and the identities of the people who inhabit it. Its purpose is twofold: (1) to explain, on micro- and macro-levels, the processes of enregisterment (Agha 2003) of Southern US English, drawing conclusions about the phenomenon of enregisterment more generally; and (2) to articulate the relationship of Southern redneck identity to this process of enregisterment. It uses a mixed-methods approach that relies primarily on a Critical Discourse Analysis (CDA) methodology, adopting a stancetaking approach (Du Bois 2007) and an enregisterment approach to language and identity, with some quantitative elements, to analyze …