Digital Commons Network^™

An Enzyme-Linked Immunosorbent Assay (Elisa)-Based Activity Assay For Amp-Activated Protein Kinase (Ampk), Trezze P Nguyen, Shangze Lyu, Yang Liu

Faculty, Staff and Student Publications

AMP-activated protein kinase (AMPK) is the master regulator of cellular and organismal energy homeostasis, playing an essential role in modulating metabolism and other cellular processes. Substantial efforts have been made to develop pharmacological modulators of AMPK activity due to their therapeutic potential against various diseases. Measuring AMPK activity in vitro is a fundamental step for testing AMPK activators and inhibitors. Here, we report an enzyme-linked immunosorbent assay (ELISA)-based AMPK activity assay with simple steps and high sensitivity. This assay offers a robust, in-house alternative to the traditional radioactive methods and other approaches that rely on specialized reagents or commercial kits.

Pharmacogenetics Of Plasma Dolutegravir Exposure During 1-Month Rifapentine/Isoniazid Treatment Of Latent Tuberculosis, Nia Covington, Anne F Luetkemeyer, Marjorie Z Imperial, Rodney Dawson, Yoninah Cramer, Sue Rosenkranz, Susan Swindells, Irina Gelmanova, Anchalee Avihingsanon, Roberto C Arduino, Wadzanai Samaneka, Kelly E Dooley, Rada Savic, Anthony T Podany, David W Haas

Faculty, Staff and Student Publications

In Advancing Clinical Therapeutics Globally protocol A5372, a pharmacokinetic study of dolutegravir with 1-month of daily rifapentine/isoniazid, twice-daily dolutegravir offset the induction effects of rifapentine on plasma dolutegravir trough concentrations (C trough ). Here, we characterize the impact on dolutegravir C trough of UGT1A1 , AADAC , and NAT2 polymorphisms that affect dolutegravir, rifapentine, and isoniazid, respectively. People with HIV receiving dolutegravir-based antiretroviral therapy with an indication to treat latent tuberculosis underwent pharmacokinetic sampling during dolutegravir 50 mg once daily alone, and on day 28 of dolutegravir 50 mg twice daily with rifapentine/isoniazid. Multivariable linear regression models characterized genetic associations …

Three-Dimensional Printed Models To Accelerate Resident Surgical Learning Curve For Standard Endoscopic Sinus Surgery Techniques, Jumah G Ahmad, Alexander J Citardi, Amber U Luong, William C Yao

Faculty, Staff and Student Publications

Background: Endoscopic sinus surgery presents significant visuospatial challenges to surgical trainees. We tested the utility of novel 3D printed models to simulate sinus surgery tasks to improve endoscopic skillsets in resident trainees.

Methods: This was a prospective quality improvement study of 10 ENT residents (PGY1-5). Participants rotated through 4 stations with different 3D simulation training modules designed to enhance endoscopic skillsets in the axial, sagittal and coronal planes (e.g., straight forceps to grasp a bead from a ledge, angled instruments to cannulate openings). Participants completed a self-assessment survey on the subjective sinus surgical skills using a visual analog …

Placenta Accreta Spectrum, Present And Future: The Eunice Kennedy Shriver National Institute Of Child Health And Human Development Workshop Summary, Christina M Duzyj, Brett D Einerson, Yalda Afshar, Karin A Fox, Antonio F Saad, Daniela A Carusi, Christina L Herrera, Deirdre J Lyell, Alfred Z Abuhamad, Michaela K Farber, Anne C Roberts, Sebastian R Hobson, Loic Sentilhes, Baha M Sibai, Koji Matsuo, Kristen Terlizzi, Scott A Shainker, Robert M Silver, Helena C Bartels, Thomas D Shipp, Marilyn Huang, Alison G Cahill, Jason D Wright, George R Saade, Monica Longo

Faculty, Staff and Student Publications

Placenta accreta spectrum (PAS) disorder poses significant risks to maternal health, given the complexities of screening, diagnosis, and management. To address these challenges, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) hosted a workshop on June 10-11, 2024, bringing together expert health care professionals, researchers, stakeholders, and patient advocates to identify knowledge gaps, with an overarching goal of informing future research and best practices for PAS. Key discussions revolved around the resources and infrastructure needed to advance screening, diagnosis, and clinical management of PAS, alongside ways to enhance collaboration across disciplines. Participants considered strategies to …

Cardio-Oncology Outcomes In Ultrasound-Assisted Versus Standard Catheter-Directed Thrombolysis For Acute Pulmonary Embolus, Dominique J Monlezun, Dinu Balanescu, Teodora Donisan, Arashk Motiei, Brenden S Ingraham, Keir Mackay, Hyeon-Ju Ali, Kevin Honan, Abdelrahman Ali, Salman Arain, Konstantinos Charitakis, Mehmet Cilingiroglu, Konstantinos Dean Boudoulas, Jaime Caballero, Konstantinos Marmagkiolis, Cezar Iliescu

Faculty, Staff and Student Publications

No abstract provided.

Endovascular Repair Of Type A Dissection Using Thoracic Stent Graft With Innominate Artery Flaring To Correct For Length Mismatch, Aidin Baghbani-Oskouei, Lucas Ruiter Kanamori, Safa Savadi, Steven Maximus, Thanila A Macedo, Anthony Estrera, Salman A Arain, Gustavo S Oderich

Faculty, Staff and Student Publications

Type A aortic dissection is the most common aortic catastrophe posing challenges for endovascular repair owing to the fragile aortic wall, proximity to the aortic valve, coronaries, and supra-aortic trunks. While open surgical repair remains the gold standard, endovascular repair is considered in select high-risk patients who meet anatomical criteria, including more than 10 mm length between sinotubular junction to primary tear, aortic diameter of less than 40 mm, and suitable length between sinotubular junction and innominate artery. This illustrated video and case presentation address a modified technique using stent graft flaring of the innominate artery to adjust for length …

Psychometrics Of Inflammatory Back Pain Criteria In The Us Population, Mark C Hwang, Seokhun Kim, Shervin Assassi, Alexis Ogdie, Michael H Weisman, John Reveille, Charles Green

Faculty, Staff and Student Publications

Objectives: Evaluation of axial spondyloarthritis relies on capturing various inflammatory back pain (IBP) features represented in different criteria. These criteria are likely to be interpreted differently across demographic subpopulations. We examined IBP criteria dimensionality and differential item functioning (DIF) among different age, gender, and race groups using a nationally representative sample.

Methods: We utilised the National Health and Nutrition Examination Survey (NHANES) 2009-2010 dataset, a US nationally representative data collection with demographic weighting. The Arthritis Questionnaire (ARQ) within NHANES included questions from published Calin, European Spondyloarthropathy Study Group, and Berlin criteria (8a and 7b). Confirmatory factor analysis (CFA) was performed …

Design Of Conquest, A Novel, Randomized, Placebo-Controlled, Phase 2b Platform Clinical Trial To Investigate New Treatments For Patients With Early Active Systemic Sclerosis With Interstitial Lung Disease, Dinesh Khanna, Luke B Evnin, Shervin Assassi, Wade W Benton, Gregory Gordon, Karina Maslova, Juergen Steffgen, Toby M Maher

Faculty, Staff and Student Publications

Objective: Safe, effective therapies are urgently needed for patients with systemic sclerosis. However, clinical trial recruitment is challenging given the limited number of people with systemic sclerosis and further restrictions imposed by eligibility criteria. Innovative approaches are needed to accelerate development of new therapies. This article describes the rationale and trial design for CONQUEST (NCT06195072), a novel platform clinical trial sponsored by the Scleroderma Research Foundation, a not-for-profit organization.

Methods: CONQUEST is a multicentre, double-blind, randomized, placebo-controlled, Phase 2b platform trial evaluating the efficacy, safety and pharmacodynamics of multiple investigational products to treat early active systemic sclerosis with …

Perceptions Of The Intensity Of Heart Failure Medications Among Hospitalized Older Adults: A Pilot Qualitative Study, Nuzha A Amjad, Saeed Shoar, Catherine Bryant, Meghan Hunt, Min Ji Kwak

Faculty, Staff and Student Publications

Background: Guidelines for heart failure (HF) management recommend high target doses for medications. These targets are based on standardized dosing regimens that rarely consider the complex challenges faced by older patients. However, little is known about such challenges perceived by older adults. We assessed older adults' perceived challenges with HF medication utilization, which may guide a more patient-centered definition of the target intensity for HF medications.

Methods: We conducted a pilot qualitative study using one-on-one, semi-structured interviews with older adults. We included patients over the age of 65 years admitted to the acute cardiac care units (cardiac intensive care unit …

Corrigendum To “Cardiac Manifestations And Outcomes Of Covid-19 Vaccine-Associated Myocarditis In The Young In The Usa: Longitudinal Results From The Myocarditis After Covid Vaccination (Maciv) Multicenter Study”, Supriya S Jain, Steven A Anderson, Jeremy M Steele, Hunter C Wilson, Juan Carlos Muniz, Jonathan H Soslow, Rebecca S Beroukhim, Victoria Maksymiuk, Xander Jacquemyn, Olivia H Frosch, Brian Fonseca, Ashraf S Harahsheh, Sujatha Buddhe, Ravi C Ashwath, Deepika Thacker, Shiraz A Maskatia, Nilanjana Misra, Jennifer A Su, Saira Siddiqui, Danish Vaiyani, Aswathy K Vaikom-House, M Jay Campbell, Jared Klein, Sihong Huang, Christopher Mathis, Matthew D Cornicelli, Madhu Sharma, Lakshmi Nagaraju, Jocelyn Y Ang, Santosh C Uppu, Preeti Ramachandran, Jyoti K Patel, Frank Han, Jason G Mandell, Jyothsna Akam-Venkata, Michael P Dilorenzo, Michael Brumund, Puneet Bhatla, Parham Eshtehardi, Karina Mehta, Katherine Glover, Matthew L Dove, Khalifah A Aldawsari, Anupam Kumar, Spencer B Barfuss, Adam L Dorfman, Prashant K Minocha, Alexandra B Yonts, Jenna Schauer, Andrew L Cheng, Joshua D Robinson, Zachary Powell, Shubhika Srivastava, Anjali Chelliah, Yamuna Sanil, Lazaro E Hernandez, Lasya Gaur, Michael Antonchak, Marla Johnston, Jonathan D Reich, Narayan Nair, Elizabeth D Drugge, Lars Grosse-Wortmann

Faculty, Staff and Student Publications

This corrects the article "Cardiac manifestations and outcomes of COVID-19 vaccine-associated myocarditis in the young in the USA: longitudinal results from the Myocarditis After COVID Vaccination (MACiV) multicenter study" in volume 76, 102809.

Prematurity And Congenial Diaphragmatic Hernia: Revisiting Outcomes In A Contemporary Cohort, Petru I Alexe, Ana Sanchez Torres, Ashley H Ebanks, Enrico Danzer, Krisa Van Meurs, Matthew T Harting, Carmen Mesas Burgos

Faculty, Staff and Student Publications

Objective: To describe outcomes in a contemporary cohort of infants born at gestational age < 34 weeks with congenital diaphragmatic hernia (CDH).

Study design: Data from the multicenter, multinational CDH Study Group (CDHSG) registry on patients born between 1995 and 2022 were analyzed. Variables including prenatal characteristics and therapy, postnatal management, and outcomes to discharge were evaluated. A t test was used for continuous variables, and for categorical variables, the Fisher exact test.

Results: In total, 13 471 patients with CDH were entered into the registry during the study period. 810 (6%) were born at < 34 weeks of gestational age. The survival rate for the preterm cohort was 45%, and 43.5% were not repaired. Survival after surgical repair was 79%, mean age at surgery was 11 days of life, and 65% required patch repair. Extracorporeal life support was used in only 7% of the cases, and 35% survived. In total, 48.9% had an associated anomaly. Oxygen at 30 days of life was required by 76.7%. Very preterm birth (< 32 weeks of gestational age) occurred in 361 patients (2.8%), with a 39.3% survival rate and a high rate of nonrepairs (50.1%). The incidence of birth at < 34 weeks of gestational age for those undergoing fetal tracheal occlusion was 30%.

Conclusions: Survival rates for infants born preterm with CDH remain low and the …

One Cutoff Is Not Enough: Assessing Different Area Deprivation Index Cutoffs For Insurance Types On Surgical Desirability Of Outcome Ranking (Door), Susanne Schmidt, Michael A Jacobs, Daniel E Hall, Karyn B Stitzenberg, Lillian S Kao, Bradley B Brimhall, Chen-Pin Wang, Laura S Manuel, Hoah-Der Su, Jonathan C Silverstein, Paula K Shireman

Faculty, Staff and Student Publications

Background: Social Determinants of Health impact health outcomes. Area Deprivation Index (ADI) is used to risk-adjust for neighborhood affluence/deprivation but guidance on choosing deprivation cutoffs is lacking. We hypothesize that different ADI cutoffs are required for different insurance types.

Methods: National Surgical Quality Improvement Program data 2013-2019 merged with electronic health records from three academic healthcare systems. Desirability of Outcome Ranking (DOOR) assessed the association of ADI cutoffs for different insurance types, adjusted for operative stress, frailty, and case status (elective, urgent, emergent). Secondary analyses assessed the association of ADI with case status.

Results: Patients with Private insurance living in …

International Multidisciplinary Consensus Recommendations On Clinical Application Of Three-Dimensional Visualization In Precision Surgery For Pediatric Liver Tumors, Qian Dong, Wenli Xiu, Benjie Tang, Eiso Hiyama, Mary T Austin, Yeming Wu, Xiaojun Yuan, Chengzhan Zhu, Chengli Liu, Hiroki Ishibashi, Karthik K Tappa, Huanmin Wang, Chuandong Sun, Yuntao Ma, Hongwei Xi, Jian Wang, Jianghua Zhan, Kyong Ihn, Mitsuo Shimada, Mingman Zhang, Mary E Brindle, Patrick B Thomas, Shigehisa Fumino, Tao Liu, Thom Lobe, Udo Rolle, Shan Wang, Xiaowen Zhai, Yoshinori Koga, Yoshiaki Kinoshita, Yuzuo Bai, Zhaozhu Li, Zhe Wen, Weikang Pan, Krysta M Sutyak, Pier C Giulianotti

Faculty, Staff and Student Publications

Background: Pediatric liver tumors are predominantly primary malignant tumors, and complete tumor resection with sufficient preservation of liver tissue is crucial for improving prognosis. However, due to the delicate anatomical structure of the pediatric liver and the relatively large size of the tumors, especially in difficult cases, the surgical challenges are substantial. While precision liver surgery are widely applied in clinical practice, pediatric cases require more customized approaches. The application of three-dimensional (3D) visualization technology is crucial for enhancing surgical accuracy, allowing for precise preoperative planning and intraoperative guidance.

Methods: This consensus was collaboratively developed by 36 experts from eight …

Support Networks And Care Needs: Insights From Older Vietnam-Born Australians Living With Chronic Disease, Thi Ngoc Minh Nguyen, Rosemary Saunders, Gordana Dermody, Lisa Whitehead

Research outputs 2022 to 2026

This study explored the support networks and care needs of older Vietnam-born adults living in Australia, using focused ethnography, and guided by Leininger's Culture Care theory. Data were collected through participant observation and in-depth interviews over 7 months in Perth, Western Australia, and analyzed thematically. Twelve participants were included. Two themes emerged: “The collectivist context of disease management” and “When in Rome, do as the Romans do.” Chronic disease self-management primarily took place within family and community settings, with ethnic communities playing a significant role. Migration-related stigma influenced perceived care needs, creating a gap between perceived and actual support. Findings …

The Equal Rights Amendment: The 28th Amendment To The U.S. Constitution, Twiss Butler, Patrick Butler

Dignity: A Journal of Analysis of Exploitation and Violence

This article reviews how Supreme Court interpretations of the 14^th Amendment have allowed laws to discriminate against women. It aims to show that the Equal Rights Amendment, ratified as the 28^th Amendment in 2020, offers a constitutional basis for eliminating all forms of legal sex discrimination against women. These forms include discrimination based on pregnancy and abortion, commodifying women’s bodies, and allowing men to intrude into women’s protected spaces. The review starts with the denial of protection for women by America’s Declaration of Independence in 1776, denounces the Supreme Court’s precedent-setting 1974 Geduldig decision, which ruled—quite illogically—that discrimination …

Lessons Learned From Sandboxing, Piloting And Policy Experimentation With Ai And Other Digital Initiatives: Part 2, Ten In-Depth Interviews, Steven M. Miller

Research Collection School Of Computing and Information Systems

This report, "Lessons Learned from Sandboxing, Piloting and Policy Experimentation with AI and Other Digital Initiatives," captures insights and experiences from project experts involved in recent digital innovation initiatives with the governments of Bangladesh, Maldives, and Kazakhstan, and from project experts actively involved with the use of AI for delivering government digital services in the EU, New Zealand, Rwanda, Singapore, United States, and Uzbekistan. The ten in-depth interview write-ups produced from these nine different country settings provide a small but highly informative sample of rich descriptions of some of the important realities, approaches, nuances, issues and challenges related to testing …

Ntire 2025 Challenge On Event-Based Image Deblurring: Methods And Results, Lei Sun, Et. Al.

Research Collection School Of Computing and Information Systems

This paper presents an overview of NTIRE 2025, the First Challenge on Event-Based Image Deblurring, detailing the proposed methodologies and corresponding results. The primary goal of the challenge is to design an event-based method that achieves high-quality image deblurring, with performance quantitatively assessed using Peak Signal-toNoise Ratio (PSNR). Notably, there are no restrictions on computational complexity or model size. The task focuses on leveraging both events and images as inputs for singleimage deblurring. A total of 199 participants registered, among whom 15 teams successfully submitted valid results, offering valuable insights into the current state of eventbased image deblurring. We anticipate …

Group-And-Match Vs. Route-Then-Insert: Order Dispatching In Vehicle-Based Dual Services (Vedus), Yue Lin, Hai Yang, Hai Wang

Research Collection School Of Computing and Information Systems

Rapid urban transportation and delivery demand and relevant resource constraints have driven the need for more efficient vehicle utilization. An innovative concept, “Vehicle-based MultiServices” (VeMuS), is a service model in which a single vehicle offers multiple services simultaneously in an urban mobility system. Similarly, “Vehicle-based Dual Services” (VeDuS) refers to a vehicle that provides two services simultaneously (Sun et al., 2023).

Analysis Of The Vicious Circle Of Education And Its Impact On Human Development In Iraq, Walaa Ibrahim Hussein, Lawrence Yahiya Saleh Al- Kubaisi

Journal of Economics and Administrative Sciences

This research focuses on the complex relationship between education quality and human development in Iraq for 2005 to 2023, emphasizing how the poor conditions in education set in place a vicious circle restricting national progress. Utilizing both inductive and deductive realms, official data of the Ministries of Education and Planning were analyzed, along with comparative international experiences. Indicators analyzed include school density, student-teacher ratio, lack of infrastructure, and limitations of vocational training for primary, secondary, and vocational educational levels. The results show a constant mismatch between students' population growth and resource allocation to education, thus summarizing an overcrowded school environment, …

Individual Or Team Analyst Reports? The Organization Of Analyst Research Activities, Xia Chen, Ning Jia, Dan Wang

Research Collection School Of Accountancy

Given the importance of research resource allocation within brokerage firms, we examine key factors that influence the issuance of individual vs. team analyst reports. Using a comprehensive sample of analyst reports from China for the 2008-2021 period, we find that this decision is influenced by (1) the brokerage firm's client interests, whereby firms held by the brokerage firm's mutual fund clients and firms that are the brokerage firm's underwriting clients receive more team than individual reports from the brokerage firm, and (2) the nature of corporate events, whereby routine events receive more team reports and nonroutine events receive more individual …

Bogging Down Investors: An Unintended Consequence Of Litigation Risk, Siwen Fu, Ke Wang, Liandong Zhang, Liu Zheng

Research Collection School Of Accountancy

Securities litigation risk is a well-recognized yet underexplored source of financial reporting complexity or unreadability. This study examines the effect of litigation risk on the readability of corporate financial reports. The 1999 Silicon Graphics Inc. (SGI) court ruling unexpectedly reduced litigation risk for firms within the Ninth Circuit Court's jurisdiction. Using a difference-in-differences design centered on the SGI court ruling, we find that, while the readability of financial reports generally declines over the sample period, treated firms in the Ninth Circuit experience a comparatively smaller decline in readability than control firms in other states after the ruling. Put differently, treated …

How Do Institutional Investors Facilitate Reporting Comparability? Evidence From Common Institutional Ownership In The United States, Xuanbo Li, Yun Lou, Rencheng Wang, Kaitang Zhou

Research Collection School Of Accountancy

We examine how common institutional investors (CIIs) facilitate the financial reporting comparability (FRC) of US firms. Common ownership increases FRC of firms that are directly owned by CIIs (via a direct effect) and has positive spillover effects on other firms in the same industry. We find spillover effects in two types of firms: (1) those that are commonly owned by different institutional investors but are connected through common firms, and (2) those that do not have any common ownership. These results suggest that the effect of common ownership goes beyond commonly owned firms and extends to non-commonly owned firms. Furthermore, …

The Experiential Value Of Gambling In F2p Gamespaces, Orlando Woods

Research Collection College of Integrative Studies

This article explores the experiential value of gambling within free-to-play (f2p) gamespaces. In doing so, it offers a more balanced understanding of the gambling/gaming interplay. Whilst existing understandings tend to focus on the assumedly predatory monetisation techniques that players are subjected to by game developers, I instead argue that a logic of gambling is integral to the f2p experience economy of Asian players. Drawing on an analysis of in-depth interviews with Singapore-based game players/developers, I show how the virtual items and worlds that players engage with through f2p gamespaces are imbued with experiential value, whilst developers leverage the volumes of …

Ecological Responsibility In The City: The Surfaces And Volumes Of Urban Mosquito Management, Orlando Woods, Sayd Randle

Research Collection College of Integrative Studies

This paper explores how ecological responsibility becomes distributed across the surfaces and volumes of the city. Our focus is urban mosquito management – specifically, the management of the Aedes aegypti mosquito, the vector by which dengue and several other diseases are transmitted to humans – and the governance strategies deployed in Singapore to manage breeding sites and mosquito outbreaks. Whilst the governance of nature in Singapore is usually undertaken by the state, the effective management of mosquitoes requires responsibility for ecological management to become distributed throughout the city. Residents are expected to assume responsibility for surficial cleanliness and the removal …

Awareness, Knowledge, And Motivations About Lifespan, Healthspan, And Healthy Longevity Medicine In The General Population: The Healthy Longevity (Helo) Conceptual Framework, Belinda Wang, Anna Szucs, Elena Sandalova, E. J. Horberg, Paul A. O'Keefe, Louis Island, Hans J. Meij, Sonny Rosenthal, Andrea B. Maier

Research Collection College of Integrative Studies

The global population is ageing and the gap between lifespan (total years lived) and healthspan (years lived free of diseases) is increasing. Healthy Longevity Medicine (HLM) is an approach to optimise health and healthspan, and it has substantial public health implications. Despite those implications, the understanding of public perspectives on this field is lacking. The HEalthy LOngevity (HELO) framework was developed through a literature review guided by expert discussions across disciplines to include evidence-based concepts of health-related decision-making, ageing, and HLM. The framework organises concepts into three components. The first two components, awareness and knowledge, explore public perception and understanding …

A Summoned Life: Vocation In The Analects, Teng-Kuan Ng

Research Collection College of Integrative Studies

This article explores the concept of vocation in the Analects. While most treatmentsof vocation focus on the Christian tradition, and while Confucian thought is oftenviewed as categorically nontheistic, Robert Merrihew Adams’s Finite and InfiniteGoods (1999) presents an illuminating comparative framework for tracing outKongzi’s religious ethical vision of how persons think, act, and feel when graspedby a sense of divine calling. I argue that in the Analects a vocation is compositelyconceived as: (1) a special divine imperative to an individual or a community (2) tolove particular goods within one’s actual circumstances (3) with nonconsequentialist,noncompetitive, and potentially counter-cultural commitment (4) such that …

Exposure To Different Motives Of Scientists Moderates Responses To Scientific Consensus: The Case Of Cultured Meat, Kimin Eom, Bryan Kwok Cheng Choy

Research Collection School of Social Sciences

This research examines how exposure to different motives of scientists affects the impact of scientific consensus on public attitudes toward cultured meat. While scientific consensus on the safety of cultured meat generally increased positive attitudes toward it, this effect depended on information about scientists’ motives. Exposure to information about scientists’ financial motives weakened the positive effect of scientific consensus because it undermined trust in scientists. Information about scientists’ prosocial motives did not influence the scientific consensus effect. These findings suggest that perceived motives can shift trust in experts, thereby affecting the influence of experts on public attitudes.

Potential And Pitfalls Of Romantic Artificial Intelligence (Ai) Companions: A Systematic Review, Qi Hui Jerlyn Ho, Meilan Hu, Tracy Xi Chen, Andree Hartanto

Research Collection School of Social Sciences

As Artificial Intelligence (AI) becomes more integrated into daily life, individuals have increasingly turned to AIdriven systems for emotional support, companionship, and even romantic relationships. These relationships can be both beneficial and detrimental. Given the need for a comprehensive understanding of this phenomenon, this systematic review uses Sternberg’s Triangular Theory of Love to provide a holistic summary of its key potentials and pitfalls. A total of 23 articles were identified from the following databases: EBSCOhost ERIC, EBSCOhost PsycInfo, PubMed, Scopus, and Web of Science. Results highlighted the key potentials of being in a romantic relationship with AI companions as: the …

Neuroticism Predicts Constructive Conflict Resolution Styles In Conscientious Individuals: Evidence From Self-Reports And Observer Ratings, Frosch Yi Xuan Quek, Hwajin Yang, Andree Hartanto

Research Collection School of Social Sciences

The ability to resolve conflict is crucial for maintaining healthy relationships and psychological well-being. However, prior research has often overlooked the potential benefits of neuroticism for conflict resolution styles, due to a reliance on self-report measures and the lack of consideration of healthy neuroticism. This study examined the relationship between neuroticism and conflict resolution styles and highlights the pivotal role of conscientiousness and measurement modalities. Employing both self-reports and observer ratings of the Conflict Resolution Styles Inventory (CRSI), we analyzed data from young adults (N = 259) using structural equation modeling analysis. Self-reports indicated that neuroticism was associated with unconstructive …

Higher Education Is Under Siege: It Needs To Reinvent Itself, Lily Kong

Research Collection School of Social Sciences

In an op-ed for The Straits Times, SMU President Professor Lily Kong reflects on the urgent need for universities to respond to the growing convergence of pressures facing higher education – including political scrutiny, funding constraints, technological disruption, and public scepticism. She calls for a reimagining of the university’s purpose: one that moves beyond knowledge acquisition and employment outcomes to embrace holistic student development, lifelong learning, and social relevance. Highlighting the importance of resilience, self-awareness, and adaptability, Prof Kong emphasises that learning happens as much outside the classroom as within it – through mentoring, community engagement, reflection, and lived experience. …